阅读说明：本技术 复方滁菊鼻嗅制剂及其制备方法和应用 (Compound Chuzhou chrysanthemum snuff preparation as well as preparation method and application thereof ) 是由 俞浩 牛振华 于 2019-09-11 设计创作，主要内容包括：本发明公开了一种复方滁菊鼻嗅制剂,包括以下原料及重量：滁菊6g～10g；细辛1g～3g；白芷2g～10g；辛夷2g～10g；薄荷2g～6g；冰片0.1g～0.3g。还提供了复方滁菊鼻嗅制剂的制备方法、以及复方滁菊鼻嗅制剂在用作治疗鼻炎的药物中的应用。本发明复方滁菊鼻嗅制剂具有使用方便、无痛苦、无创伤,且安全无不良反应、效果显著、药效作用维持时间长等优点,制剂有效成分即可通过鼻腔粘膜吸收,挥发性成分又可随患者呼吸进入肺部,设计巧妙,组成简单,制备简便,成本低,适于大规模推广应用。(The invention discloses a compound Chuzhou chrysanthemum snuff preparation, which comprises the following raw materials in parts by weight: 6-10 g of Chuzhou chrysanthemum; 1g to 3g of asarum; 2-10 g of radix angelicae; 2 g-10 g of biond magnolia flower; 2g to 6g of mint; 0.1g to 0.3g of borneol. Also provides a preparation method of the compound Chuzhou chrysanthemum snuff preparation and application of the compound Chuzhou chrysanthemum snuff preparation in medicines for treating rhinitis. The compound chrysanthemum snuff preparation has the advantages of convenience in use, no pain, no wound, safety, no adverse reaction, remarkable effect, long duration of drug effect and the like, active ingredients of the preparation can be absorbed through nasal mucosa, volatile ingredients can enter the lung along with the breath of a patient, and the preparation is ingenious in design, simple in composition, simple and convenient to prepare, low in cost and suitable for large-scale popularization and application.)

1. the compound Chuzhou chrysanthemum snuff preparation is characterized by comprising the following raw materials in parts by weight:

6-10 g of Chuzhou chrysanthemum;

1g to 3g of asarum;

2-10 g of radix angelicae;

2 g-10 g of biond magnolia flower;

2g to 6g of mint;

0.1g to 0.3g of borneol.

2. the compound chrysanthemum snuff according to claim 1, wherein the compound chrysanthemum snuff is prepared by the following steps:

(1) drying, crushing and sieving the Chuzhou chrysanthemum, the asarum, the angelica dahurica, the magnolia flower and the mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder;

(2) Adding water into the borneol powder, grinding to form paste, adding additional water, stirring to form suspension, pouring the suspension, standing to obtain borneol precipitate, and drying to obtain borneol grinding powder;

(3) Uniformly mixing the Chuzhou chrysanthemum powder, the asarum powder, the angelica dahurica powder, the magnolia flower powder, the mint powder and the borneol grinding powder to obtain a powder mixture, adding the powder mixture into a sodium carboxymethylcellulose solution with the weight of 0.5%, and uniformly stirring to obtain a liquid medicine;

(4) Placing filter paper in the medicinal liquid, taking out after soaking, rolling into hollow cylinder, sterilizing, and drying in the shade.

3. the compound chrysanthemum nasum preparation of claim 2, wherein in the step (1), the drying temperature is 30 ℃ to 35 ℃, the pulverization is performed by using a superfine pulverizer, and the sieving is performed by using a 400-mesh sieve.

4. The compound chrysanthemum snuff according to claim 2, wherein in the step (2), the weight-to-volume ratio of the borneol powder to the water is 1: 1, the volume ratio of said paste to said additional water being 1: 10, and the drying temperature is 30-35 ℃.

5. The compound chrysanthemum snuff according to claim 2, wherein in the step (3), the weight-to-volume ratio of the powder mixture to the 0.5 wt% sodium carboxymethyl cellulose solution is 1: 1.

6. The preparation method of the compound chrysanthemum snuff according to claim 1, wherein the preparation method comprises the following steps:

(1) Drying, crushing and sieving the Chuzhou chrysanthemum, the asarum, the angelica dahurica, the magnolia flower and the mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder;

(2) Adding water into the borneol powder, grinding to form paste, adding additional water, stirring to form suspension, pouring the suspension, standing to obtain borneol precipitate, and drying to obtain borneol grinding powder;

(3) Uniformly mixing the Chuzhou chrysanthemum powder, the asarum powder, the angelica dahurica powder, the magnolia flower powder, the mint powder and the borneol grinding powder to obtain a powder mixture, adding the powder mixture into a sodium carboxymethylcellulose solution with the weight of 0.5%, and uniformly stirring to obtain a liquid medicine;

(4) placing filter paper in the medicinal liquid, taking out after soaking, rolling into hollow cylinder, sterilizing, and drying in the shade.

7. The method for preparing the compound chrysanthemum snuff preparation according to claim 6, wherein in the step (1), the drying temperature is 30-35 ℃, the pulverization is performed by using an ultrafine pulverizer, and the sieving is performed by using a 400-mesh sieve.

8. The method for preparing the compound chrysanthemum snuff according to claim 6, wherein in the step (2), the weight-to-volume ratio of the borneol powder to the water is 1: 1, the volume ratio of said paste to said additional water being 1: 10, and the drying temperature is 30-35 ℃.

9. the method for preparing a compound chrysanthemum snuff according to claim 6, wherein in the step (3), the weight-to-volume ratio of the powder mixture to the 0.5% by weight sodium carboxymethyl cellulose solution is 1: 1.

10. Use of the compound chrysanthemum snuff according to any one of claims 1-5 for treating rhinitis.

Technical Field

The invention relates to the technical field of traditional Chinese medicine preparations and preparation and application thereof, in particular to a traditional Chinese medicine preparation for treating rhinitis and the technical field of preparation and application thereof, and specifically relates to a compound chrysanthemum and Chuzhou snuff preparation and a preparation method and application thereof.

background

Rhinitis refers to inflammatory diseases of nasal cavity, and inflammation of nasal mucosa can be caused by viruses, bacteria, allergens, various physicochemical factors and certain systemic diseases. The main symptoms of rhinitis include nasal obstruction, watery nasal discharge, headache, dizziness and hyposmia, and most people also have symptoms of inappetence, fatiguability, hypomnesis, insomnia and the like. Meanwhile, rhinitis can also cause related complications, such as asthma, conjunctivitis, chronic rhinosinusitis, adenoid hypertrophy, secretory otitis media and the like. The data show that the incidence rate of rhinitis in China is as high as 37%, 1-3 people in 10 people suffer from allergic rhinitis in different degrees, and the number of the suffering people in China is estimated to be more than 1 hundred million. The incidence of allergic rhinitis in adults in western countries is generally 10% -20%, and even up to 30% in some developed countries. It can be seen that rhinitis is a global health problem that can lead to many illnesses, and that serious individuals can cause labor loss.

Rhinitis is a multifactorial disease induced by the interaction of genes and the environment, and the pathogenesis of the rhinitis is related to virus infection, genetic factors, nasal mucosa susceptibility, allergen and the like. Allergic rhinitis is mainly associated with genetic factors and allergens, the disease usually presents familial aggregative properties, and research finds that allergic rhinitis is associated with certain genes. Allergic rhinitis may be caused by mites, pollen, animal dander, allergic spores released by fungi, cockroach feces, allergens present in food, and the like.

the rhinitis treatment method mainly comprises four methods: one is to avoid contact with allergens. The method has certain effect, but the allergen is ubiquitous in the living environment of people, and the prevention is often insufficient. The second is medication. The medicine is usually administrated intranasally and orally, and has definite curative effect. However, the curative effect of different patients is different, the long-term continuous curative effect is not achieved after the medicine is stopped, and the adverse reaction of hormone, antihistamine and anticholinergic is a problem that the continuous medication needs special attention. And thirdly, immunotherapy. Immunotherapy induces clinical and immunological tolerance, has long-term effects and can prevent the development of allergic diseases, but this method may have local and systemic adverse reactions. Fourthly, surgical treatment. The surgical treatment indication is that the symptoms are not improved by medicines or immunotherapy, and obvious physical signs exist, so that the quality of life is influenced; the nasal cavity has obvious anatomical variation accompanied with functional disorder; patients with chronic rhino-sinusitis and nasal polyps who are ineffectual in drug therapy are not treated as a conventional method for treating rhinitis.

Therefore, it is desirable to provide a medicament for treating rhinitis, which has the advantages of convenient use, no pain, no wound, safety, no adverse reaction, remarkable effect, long duration of efficacy, and the like.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention aims to provide the compound chrysanthemum snuff preparation which has the advantages of convenience in use, no pain, no wound, safety, no adverse reaction, remarkable effect, long duration of drug effect action and the like.

the invention also aims to provide a compound Chuzhou chrysanthemum snuff preparation which is ingenious in design, simple in composition, simple and convenient to prepare, low in cost and suitable for large-scale popularization and application.

The invention also aims to provide a preparation method of the compound chrysanthemum snuff preparation, the prepared compound chrysanthemum snuff preparation has the advantages of convenience in use, no pain, no wound, safety, no adverse reaction, remarkable effect, long duration of drug effect action and the like, active ingredients of the preparation can be absorbed through nasal mucosa, and volatile ingredients can enter lung along with breath of a patient, so that the preparation method is suitable for large-scale popularization and application.

The invention also aims to provide a preparation method of the compound Chuzhou chrysanthemum snuff preparation, which is ingenious in design, simple to operate and suitable for large-scale popularization and application.

The invention also aims to provide application of the compound chrysanthemum snuff preparation, which can be used for treating rhinitis and has the advantages of convenience in use, no pain, no wound, safety, no adverse reaction, remarkable effect, long duration of drug effect action and the like.

the invention also aims to provide application of the compound Chuzhou chrysanthemum snuff preparation, which is ingenious in design, simple to operate and suitable for large-scale popularization and application.

In order to achieve the above object, in a first aspect of the present invention, there is provided a compound chrysanthemum snuff preparation, which is characterized by comprising the following raw materials by weight:

6-10 g of Chuzhou chrysanthemum;

1g to 3g of asarum;

2-10 g of radix angelicae;

2 g-10 g of biond magnolia flower;

2g to 6g of mint;

0.1g to 0.3g of borneol.

Preferably, the compound Chuzhou chrysanthemum snuff preparation is prepared by the following steps:

(1) Drying, crushing and sieving the Chuzhou chrysanthemum, the asarum, the angelica dahurica, the magnolia flower and the mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder;

(2) Adding water into the borneol powder, grinding to form paste, adding additional water, stirring to form suspension, pouring the suspension, standing to obtain borneol precipitate, and drying to obtain borneol grinding powder;

(3) Uniformly mixing the Chuzhou chrysanthemum powder, the asarum powder, the angelica dahurica powder, the magnolia flower powder, the mint powder and the borneol grinding powder to obtain a powder mixture, adding the powder mixture into a sodium carboxymethylcellulose solution with the weight of 0.5%, and uniformly stirring to obtain a liquid medicine;

(4) Placing filter paper in the medicinal liquid, taking out after soaking, rolling into hollow cylinder, sterilizing, and drying in the shade.

More preferably, in the step (1), the drying temperature is 30-35 ℃, the pulverization adopts an ultrafine pulverizer, and the sieving adopts a 400-mesh sieve.

more preferably, in the step (2), the weight-to-volume ratio of the borneol powder to the water is 1: 1, the volume ratio of said paste to said additional water being 1: 10, and the drying temperature is 30-35 ℃.

More preferably, in the step (3), the weight-to-volume ratio of the powder mixture to the 0.5% by weight sodium carboxymethyl cellulose solution is 1: 1.

In a second aspect of the invention, a preparation method of the compound chrysanthemum snuff preparation is provided, and is characterized by comprising the following steps:

(1) drying, crushing and sieving the Chuzhou chrysanthemum, the asarum, the angelica dahurica, the magnolia flower and the mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder;

(2) Adding water into the borneol powder, grinding to form paste, adding additional water, stirring to form suspension, pouring the suspension, standing to obtain borneol precipitate, and drying to obtain borneol grinding powder;

(3) Uniformly mixing the Chuzhou chrysanthemum powder, the asarum powder, the angelica dahurica powder, the magnolia flower powder, the mint powder and the borneol grinding powder to obtain a powder mixture, adding the powder mixture into a sodium carboxymethylcellulose solution with the weight of 0.5%, and uniformly stirring to obtain a liquid medicine;

(4) Placing filter paper in the medicinal liquid, taking out after soaking, rolling into hollow cylinder, sterilizing, and drying in the shade.

preferably, in the step (1), the drying temperature is 30-35 ℃, the pulverization adopts an ultrafine pulverizer, and the sieving adopts a 400-mesh sieve.

preferably, in the step (2), the weight-to-volume ratio of the borneol powder to the water is 1: 1, the volume ratio of said paste to said additional water being 1: 10, and the drying temperature is 30-35 ℃.

Preferably, in the step (3), the weight-to-volume ratio of the powder mixture to the 0.5% by weight sodium carboxymethyl cellulose solution is 1: 1.

In a third aspect of the invention, the application of the compound chrysanthemum snuff preparation in the use of a medicine for treating rhinitis is provided.

The invention has the following beneficial effects:

1. The compound Chuzhou chrysanthemum snuff preparation comprises the following raw materials in parts by weight: 6-10 g of Chuzhou chrysanthemum; 1g to 3g of asarum; 2-10 g of radix angelicae; 2 g-10 g of biond magnolia flower; 2g to 6g of mint; 0.1g to 0.3g of borneol, and when in use, the compound chrysanthemum snuff preparation is soaked in sesame oil and then is stuffed into the nasal cavity, so that the compound chrysanthemum snuff preparation has the advantages of convenience in use, no pain and no wound, safety, no adverse reaction, remarkable effect, long duration of drug effect action and the like, active ingredients of the preparation can be absorbed through the nasal mucosa, volatile ingredients can enter the lung along with the breathing of a patient, and the compound chrysanthemum snuff preparation is suitable for large-scale popularization and application.

2. The compound Chuzhou chrysanthemum snuff preparation comprises the following raw materials in parts by weight: 6-10 g of Chuzhou chrysanthemum; 1g to 3g of asarum; 2-10 g of radix angelicae; 2 g-10 g of biond magnolia flower; 2g to 6g of mint; 0.1-0.3 g of borneol, and when the compound chrysanthemum snuff preparation is used, the compound chrysanthemum snuff preparation is soaked in sesame oil and then is stuffed into a nasal cavity, so that the compound chrysanthemum snuff preparation is ingenious in design, simple in composition, simple and convenient to prepare, low in cost and suitable for large-scale popularization and application.

3. the preparation method of the compound Chuzhou chrysanthemum snuff preparation comprises the following steps: (1) drying, crushing and sieving Chuzhou chrysanthemum, asarum, angelica dahurica, magnolia flower and mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder; (2) adding water into Borneolum Syntheticum powder, grinding to obtain paste, adding additional water, stirring to obtain suspension, removing impurities at the bottom, standing, drying the precipitate, and grinding to obtain Borneolum Syntheticum powder; (3) mixing flos Chrysanthemi powder, herba asari powder, radix Angelicae Dahuricae powder, flos Magnoliae powder, herba Menthae powder and Borneolum Syntheticum powder to obtain powder mixture, adding the powder mixture into 0.5 wt% sodium carboxymethylcellulose solution, and stirring to obtain medicinal liquid; (4) the compound chrysanthemum snuff preparation has the advantages of convenience in use, no pain, no wound, safety, no adverse reaction, remarkable effect, long duration of drug effect and the like, active ingredients of the preparation can be absorbed through nasal mucosa, and volatile ingredients can enter the lung along with the breathing of a patient, so that the compound chrysanthemum snuff preparation is suitable for large-scale popularization and application.

4. The preparation method of the compound Chuzhou chrysanthemum snuff preparation comprises the following steps: (1) drying, crushing and sieving Chuzhou chrysanthemum, asarum, angelica dahurica, magnolia flower and mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder; (2) adding water into Borneolum Syntheticum powder, grinding to obtain paste, adding additional water, stirring to obtain suspension, removing impurities at the bottom, standing, drying the precipitate, and grinding to obtain Borneolum Syntheticum powder; (3) mixing flos Chrysanthemi powder, herba asari powder, radix Angelicae Dahuricae powder, flos Magnoliae powder, herba Menthae powder and Borneolum Syntheticum powder to obtain powder mixture, adding the powder mixture into 0.5 wt% sodium carboxymethylcellulose solution, and stirring to obtain medicinal liquid; (4) the compound Chuzhou chrysanthemum snuff preparation is prepared by soaking the compound Chuzhou chrysanthemum snuff preparation in sesame oil and then filling the soaked compound Chuzhou chrysanthemum snuff preparation into a nasal cavity, so that the compound Chuzhou chrysanthemum snuff preparation is ingenious in design, simple to operate and suitable for large-scale popularization and application.

5. the compound chrysanthemum snuff preparation can be used for treating rhinitis, and when the compound chrysanthemum snuff preparation is used, the compound chrysanthemum snuff preparation is soaked in sesame oil and then is stuffed into a nasal cavity, so that the compound chrysanthemum snuff preparation has the advantages of convenience in use, no pain, no wound, safety, no adverse reaction, remarkable effect, long duration of drug effect action and the like, active ingredients of the preparation can be absorbed through a nasal cavity mucosa, volatile ingredients can enter the lung along with the breathing of a patient, and the compound chrysanthemum snuff preparation is suitable for large-scale popularization and application.

6. the compound chrysanthemum snuff preparation can be used for treating rhinitis, and when the compound chrysanthemum snuff preparation is used, the compound chrysanthemum snuff preparation is soaked in sesame oil and then is stuffed into a nasal cavity, so that the compound chrysanthemum snuff preparation is ingenious in design, simple to operate and suitable for large-scale popularization and application.

these and other objects, features and advantages of the present invention will become more fully apparent from the following detailed description and appended claims, and may be realized by means of the instrumentalities, devices and combinations particularly pointed out in the appended claims.

Detailed Description

in order to avoid side effects caused by the existing main means for treating rhinitis, the inventor provides a compound Chuzhou chrysanthemum snuff preparation, which comprises the following raw materials in parts by weight:

6-10 g of Chuzhou chrysanthemum;

1g to 3g of asarum;

2-10 g of radix angelicae;

2 g-10 g of biond magnolia flower;

2g to 6g of mint;

0.1g to 0.3g of borneol.

The compound chrysanthemum snuff preparation can be prepared from the raw materials with the weight, and preferably, the compound chrysanthemum snuff preparation is prepared by the following steps:

(1) drying, crushing and sieving the Chuzhou chrysanthemum, the asarum, the angelica dahurica, the magnolia flower and the mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder;

(2) adding water into the borneol powder, grinding to form paste, adding additional water, stirring to form suspension, pouring the suspension, standing to obtain borneol precipitate, and drying to obtain borneol grinding powder;

(3) uniformly mixing the Chuzhou chrysanthemum powder, the asarum powder, the angelica dahurica powder, the magnolia flower powder, the mint powder and the borneol grinding powder to obtain a powder mixture, adding the powder mixture into a sodium carboxymethylcellulose solution with the weight of 0.5%, and uniformly stirring to obtain a liquid medicine;

(4) Placing filter paper in the medicinal liquid, taking out after soaking, rolling into hollow cylinder, sterilizing, and drying in the shade.

In the step (1), the drying temperature, the equipment for crushing and the device for sieving can be determined according to requirements, and preferably, in the step (1), the drying temperature is 30-35 ℃, the crushing adopts a superfine crusher, and the sieving adopts a 400-mesh sieve.

in the step (2), the amount of the water, the amount of the additional water, and the drying temperature may be determined as needed, and more preferably, in the step (2), the weight-to-volume ratio of the borneol powder to the water is 1: 1, the volume ratio of said paste to said additional water being 1: 10, and the drying temperature is 30-35 ℃.

In the step (3), the addition amount of the 0.5% by weight sodium carboxymethyl cellulose solution may be determined according to the requirement, and more preferably, in the step (3), the weight-to-volume ratio of the powder mixture to the 0.5% by weight sodium carboxymethyl cellulose solution is 1: 1.

The invention also provides a preparation method of the compound Chuzhou chrysanthemum snuff preparation, which comprises the following steps:

(1) Drying, crushing and sieving the Chuzhou chrysanthemum, the asarum, the angelica dahurica, the magnolia flower and the mint to respectively obtain Chuzhou chrysanthemum powder, asarum powder, angelica dahurica powder, magnolia flower powder and mint powder;

(2) Adding water into the borneol powder, grinding to form paste, adding additional water, stirring to form suspension, pouring the suspension, standing to obtain borneol precipitate, and drying to obtain borneol grinding powder;

(3) Uniformly mixing the Chuzhou chrysanthemum powder, the asarum powder, the angelica dahurica powder, the magnolia flower powder, the mint powder and the borneol grinding powder to obtain a powder mixture, adding the powder mixture into a sodium carboxymethylcellulose solution with the weight of 0.5%, and uniformly stirring to obtain a liquid medicine;

(4) placing filter paper in the medicinal liquid, taking out after soaking, rolling into hollow cylinder, sterilizing, and drying in the shade.

In the step (1), the drying temperature, the equipment for crushing and the device for sieving can be determined according to requirements, and preferably, in the step (1), the drying temperature is 30-35 ℃, the crushing adopts a superfine crusher, and the sieving adopts a 400-mesh sieve.

in the step (2), the amount of the water, the amount of the additional water, and the drying temperature may be determined as needed, and more preferably, in the step (2), the weight-to-volume ratio of the borneol powder to the water is 1: 1, the volume ratio of said paste to said additional water being 1: 10, and the drying temperature is 30-35 ℃.

In the step (3), the addition amount of the 0.5% by weight sodium carboxymethyl cellulose solution may be determined according to the requirement, and more preferably, in the step (3), the weight-to-volume ratio of the powder mixture to the 0.5% by weight sodium carboxymethyl cellulose solution is 1: 1.

the invention also provides application of the compound Chuzhou chrysanthemum snuff preparation in medicines for treating rhinitis.

In order to clearly understand the technical contents of the present invention, the following examples are given in detail. In the present invention, the components or raw materials are all conventional commercially available products, or can be obtained by means of conventional techniques in the art. Wherein:

Chuzhou chrysanthemum (from chrysanthemum Tai Chuzhou chrysanthemum science and technology Co., Ltd., Anhui)

Asarum (purchased from Bozhou repuntang pharmaceutical Co., Ltd.)

Radix Angelicae Dahuricae (purchased from Bozhou repuntang pharmaceutical Co., Ltd.)

biond magnolia (purchased from Bozhou reputations Tang pharmaceutical Co., Ltd.)

Mint (from Bozhou repurposing pharmaceutical Co., Ltd.)

Borneol (from Bozhou city Guimeikang Chinese medicinal material sales Co., Ltd.)

Sodium carboxymethylcellulose (from Jiangsu Caoswei Biotechnology Co., Ltd.)