阅读说明：本技术 一种黄枣颗粒及其制作工艺 (yellow jujube particles and preparation process thereof ) 是由 孙志剑 于 2019-10-09 设计创作，主要内容包括：本发明涉及中药颗粒的制作,尤其涉及一种黄枣颗粒及其制作工艺。黄枣颗粒,其组成成分的重量比如下：包括当归、黄芪、大枣以及蔗糖。黄枣颗粒的生产工艺包括步骤一,提取与精制；步骤二,粉碎；步骤三,原料混合；步骤四,二次制粒；步骤五,干燥；步骤六,选粒；步骤七,成品混合；本生产工艺制得的黄枣颗粒生产的颗粒较为均匀、成品率高。(The invention relates to preparation of traditional Chinese medicine granules, in particular to yellow jujube granules and a preparation process thereof. The yellow jujube particles comprise the following components in percentage by weight: comprises radix Angelicae sinensis, radix astragali, fructus Jujubae and sucrose. The production process of the yellow jujube particles comprises the steps of I, extracting and refining; step two, crushing; step three, mixing the raw materials; step four, granulating for the second time; step five, drying; step six, selecting particles; step seven, mixing finished products; the yellow jujube particles prepared by the production process are uniform in particle production and high in yield.)

1. The yellow jujube particles are characterized by comprising the following components in percentage by weight: comprises 120-150 g of angelica, 80-120 g of astragalus, 80-120 g of jujube and 900-1000 g of cane sugar.

2. The yellow date particle of claim 1, wherein: 150g of angelica, 100g of astragalus, 100g of Chinese date and 950g of cane sugar.

3. A process for producing the yellow jujube granules according to claim 1, characterized by the following steps:

Step one, extraction and refining:

step S1, putting the angelica sinensis clean medicinal material into an extraction tank, adding ethanol, heating to boil, keeping the temperature at 70-80 ℃, timing when ethanol refluxes, refluxing for 3 hours, finishing the refluxes, continuously transferring the liquid medicine into a concentrator through a filter, controlling the vacuum degree at 0.04-0.07 Mpa and the temperature at 50-70 ℃, recovering ethanol, and concentrating to the relative density of 1.04(50 ℃);

Step S2, putting the angelica dregs and the Chinese date medicinal materials into an extraction tank, decocting twice, adding drinking water for decocting for 1.5 hours for the first time, and filtering decoction; decocting with drinking water for 1 hr, filtering decoction, mixing filtrates, adding into a concentrator, and concentrating to obtain fluid extract with relative density of 1.10 (50 deg.C);

step S3, injecting the clear paste into an alcohol precipitation tank, operating equipment according to the operating rules of the alcohol precipitation tank, stirring, slowly adding 95% ethanol, adding ethanol to enable the ethanol content to reach 60%, stirring, keeping the temperature of the liquid medicine not to exceed 25 ℃, standing for 24 hours, filtering, taking supernate, transferring the supernate into a vacuum concentration tank, operating according to the operating rules of the vacuum concentration tank, opening a steam valve, controlling the steam pressure to be 0.02-0.1 Mpa, controlling the temperature to be 50-70 ℃, and recovering the ethanol;

Step S4, the clean medicinal material of the astragalus is taken and put into an extraction tank to be decocted twice, drinking water is added for 2 hours for the first time to be decocted, the decoction liquid is filtered, drinking water is added for the second time to be decocted for 1.5 hours for the second time to be filtered, the decoction liquid is filtered, the secondary filtrate is combined and kept stand for 24 hours, the supernatant liquid is taken to be combined with the angelica and Chinese date liquid to be injected into a concentrator to be concentrated into thick paste with the relative density of 1.30 (60 ℃);

step two, crushing: preparing sucrose into sucrose fine powder by using a universal pulverizer;

Step three, mixing raw materials: dividing the sucrose fine powder and the soft extract into a plurality of equal parts, adding one part of the sucrose fine powder and one part of the soft extract into a high-speed mixing granulator, fully mixing, stirring and cutting to obtain a soft material, and closing the machine when the color of the soft material is uniform;

step four, granulating: adding the wet granules into a swing type granulator, and sieving the granules by a sieve;

Step five, drying: placing the granules in the fourth step into a fluidized bed granulator, setting the temperature to be 70 ℃, controlling the air inlet temperature to be 65-75 ℃, controlling the material temperature to be 35-65 ℃, adjusting the speed of a spray gun to be 150-250 Hz, spraying the angelica sinensis ethanol extract, drying for 5-10 minutes after spraying, controlling the moisture content not to exceed 3 percent to obtain dry granules, and atomizing the wet granules in the process;

step six, particle selection: placing the dry granules into a ternary oscillating screen, and screening and selecting granules;

Step seven, mixing finished products: adding the qualified granules selected in the step five into a one-dimensional motion mixer, and mixing for 10 minutes;

Step eight, packaging: and packaging the granules obtained in the sixth step.

4. The yellow date particle production process according to claim 3, characterized in that: during the whole granulation process, the materials are circulated in a closed system, and the inside of the closed system is kept at negative pressure relative to the outside.

5. the yellow date particle production process according to claim 4, characterized in that: and step four, sterilizing by using a tunnel microwave drying sterilizer.

6. the yellow date particle production process according to claim 5, characterized in that: the screen used in step three and step four is a 12-mesh screen.

7. The yellow date particle production process according to claim 6, characterized in that: and screening by using 10-mesh and 80-mesh screens in the fifth step.

Technical Field

The invention relates to preparation of traditional Chinese medicine granules, in particular to yellow jujube granules and a preparation process thereof.

background

the yellow jujube particles are loaded in WS-11326(ZD-1326) -2002-2012Z of the national food and drug administration drug Standard. Belongs to qi-tonifying and blood-nourishing medicine. Can be used for treating menoxenia, hypomenorrhea, short breath, and asthenia due to blood deficiency.

The yellow jujube particles are used for treating female deficiency of qi and cold in blood, have good drug effect and are widely praised by patients. Therefore, the process for preparing the yellow jujube particles is very important. The traditional swing type granulator wet granulation method adopted before the previously produced yellow jujube particles is adopted, the particle size of the particles produced by the process is not uniform enough, and the yield of finished products is low. The uneven particle size of the yellow jujube particles leads to different sizes of the medicines, which is not beneficial to the overflow of the effective components. Because the yield of finished products is low, the production efficiency is influenced, and the production task cannot be completed on time.

Disclosure of Invention

The invention provides yellow jujube particles and a manufacturing process thereof, which aim to solve the problems of uneven particles and low yield of the existing yellow jujube particles.

The yellow jujube particles adopt the following technical scheme: the invention relates to yellow jujube particles, which comprise the following components in percentage by weight: comprises 120-150 g of angelica, 80-120 g of astragalus, 80-120 g of jujube and 900-1000 g of cane sugar.

Furthermore, 150g of angelica, 100g of astragalus, 100g of Chinese date and 950g of cane sugar. The invention relates to a preparation process of yellow jujube particles, which adopts the following technical scheme:

Step one, extraction and refining:

step S1, putting the angelica sinensis clean medicinal material into an extraction tank, adding ethanol, heating to boil, keeping the temperature at 70-80 ℃, timing when ethanol refluxes, refluxing for 3 hours, finishing the refluxes, continuously transferring the liquid medicine into a concentrator through a filter, controlling the vacuum degree at 0.04-0.07 Mpa and the temperature at 50-70 ℃, recovering ethanol, and concentrating to the relative density of 1.04(50 ℃);

Step S2, putting the angelica dregs and the Chinese date medicinal materials into an extraction tank, decocting twice, adding drinking water for decocting for 1.5 hours for the first time, and filtering decoction; decocting with drinking water for 1 hr, filtering decoction, mixing filtrates, adding into a concentrator, and concentrating to obtain fluid extract with relative density of 1.10 (50 deg.C);

step S3, injecting the clear paste into an alcohol precipitation tank, operating equipment according to the operating rules of the alcohol precipitation tank, stirring, slowly adding 95% ethanol, adding ethanol to enable the ethanol content to reach 60%, stirring, keeping the temperature of the liquid medicine not to exceed 25 ℃, standing for 24 hours, filtering, taking supernate, transferring the supernate into a vacuum concentration tank, operating according to the operating rules of the vacuum concentration tank, opening a steam valve, controlling the steam pressure to be 0.02-0.1 Mpa, controlling the temperature to be 50-70 ℃, and recovering the ethanol;

Step S4, the clean medicinal material of the astragalus is taken and put into an extraction tank to be decocted twice, drinking water is added for 2 hours for the first time to be decocted, the decoction liquid is filtered, drinking water is added for the second time to be decocted for 1.5 hours for the second time to be filtered, the decoction liquid is filtered, the secondary filtrate is combined and kept stand for 24 hours, the supernatant liquid is taken to be combined with the angelica and Chinese date liquid to be injected into a concentrator to be concentrated into thick paste with the relative density of 1.30 (60 ℃);

Step two, crushing: preparing sucrose into sucrose fine powder by using a universal pulverizer;

step three, mixing raw materials: dividing the sucrose fine powder and the soft extract into a plurality of equal parts, adding one part of the sucrose fine powder and one part of the soft extract into a high-speed mixing granulator, fully mixing, stirring and cutting to obtain a soft material, and closing the machine when the color of the soft material is uniform;

step four, granulating: adding the wet granules into a swing type granulator, and sieving the granules by a sieve;

Step five, drying: placing the granules in the fourth step into a fluidized bed granulator, setting the temperature to be 70 ℃, controlling the air inlet temperature to be 65-75 ℃, controlling the material temperature to be 35-65 ℃, adjusting the speed of a spray gun to be 150-250 Hz, spraying the angelica sinensis ethanol extract, drying for 5-10 minutes after spraying, controlling the moisture content not to exceed 3 percent to obtain dry granules, and atomizing the wet granules in the process;

step six, particle selection: placing the dry granules into a ternary oscillating screen, and screening and selecting granules;

step seven, mixing finished products: adding the qualified granules selected in the step five into a one-dimensional motion mixer, and mixing for 10 minutes;

Step eight, packaging: and packaging the granules obtained in the sixth step.

furthermore, the material flows in a closed system during the whole granulation process, and the inside of the closed system is kept at a negative pressure relative to the outside.

further, sterilizing by using a tunnel microwave drying sterilizer in the fourth step.

further, the screen used in the third step and the fourth step is a 12-mesh screen.

further, in the fifth step, 10-mesh and 80-mesh screens are selected for sieving operation.

The invention has the beneficial effects that: the process fully extracts the effective components of the angelica, the Chinese date and the astragalus by the first step, particularly the operations of the steps S1 to S4, thereby improving the content of the medicinal components. The raw materials are mixed more uniformly by arranging the high-speed mixing granulator. The wet granulator who sets up and swing formula granulation machine make more even of pelletization to two equipment all sieve the operation after carrying out the pelletization respectively, greatly reduced unqualified wide granule, improved the yield. The particulate extract of the yellow jujube is atomized, granulated and dried by adding to a fluid bed granulator. Compared with the traditional drying equipment, the drying speed of the device is greatly improved, and the loss of effective components caused by overlong drying time in the traditional mode is avoided.

drawings

in order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

FIG. 1 is a flow chart of an embodiment of the process for making yellow date particles according to the present invention;

FIG. 2 is a flow chart of the extraction and refining of step one.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

the invention relates to yellow jujube particles, which comprise the following components in percentage by weight: comprises 120-150 g of angelica, 80-120 g of astragalus, 80-120 g of jujube and 900-1000 g of cane sugar.

preferably 150g of angelica, 100g of astragalus, 100g of Chinese date and 950g of cane sugar.

an embodiment of the process for making yellow jujube granules, as shown in figure 1,

Step one, extraction and refining:

step S1, putting the angelica sinensis clean medicinal material into an extraction tank, adding ethanol, heating to boil, keeping the temperature at 70-80 ℃, timing when ethanol refluxes, refluxing for 3 hours, finishing the refluxes, continuously transferring the liquid medicine into a concentrator through a filter, controlling the vacuum degree at 0.04-0.07 Mpa and the temperature at 50-70 ℃, recovering ethanol, and concentrating to the relative density of 1.04(50 ℃);

Step S2, putting the angelica dregs and the Chinese date medicinal materials into an extraction tank, decocting twice, adding drinking water for decocting for 1.5 hours for the first time, and filtering decoction; decocting with drinking water for 1 hr, filtering decoction, mixing filtrates, adding into a concentrator, and concentrating to obtain fluid extract with relative density of 1.10 (50 deg.C);

step S3, injecting the clear paste into an alcohol precipitation tank, operating equipment according to the operating rules of the alcohol precipitation tank, stirring, slowly adding 95% ethanol, adding ethanol to enable the ethanol content to reach 60%, stirring, keeping the temperature of the liquid medicine not to exceed 25 ℃, standing for 24 hours, filtering, taking supernate, transferring the supernate into a vacuum concentration tank, operating according to the operating rules of the vacuum concentration tank, opening a steam valve, controlling the steam pressure to be 0.02-0.1 Mpa, controlling the temperature to be 50-70 ℃, and recovering the ethanol;

step S4, the clean medicinal material of the astragalus is taken and put into an extraction tank to be decocted twice, drinking water is added for 2 hours for the first time to be decocted, the decoction liquid is filtered, drinking water is added for the second time to be decocted for 1.5 hours for the second time to be filtered, the decoction liquid is filtered, the secondary filtrate is combined and kept stand for 24 hours, the supernatant liquid is taken to be combined with the angelica and Chinese date liquid to be injected into a concentrator to be concentrated into thick paste with the relative density of 1.30 (60 ℃);

step two, crushing: preparing sucrose into sucrose fine powder by using a universal pulverizer;

Step three, mixing raw materials: dividing the sucrose fine powder and the soft extract into a plurality of equal parts, adding one part of the sucrose fine powder and one part of the soft extract into a high-speed mixing granulator, fully mixing, stirring and cutting to obtain a soft material, and closing the machine when the color of the soft material is uniform;

Step four, granulating: adding the wet granules into a swing type granulator, and sieving the granules by a sieve;

Step five, drying: placing the granules in the fourth step into a fluidized bed granulator, setting the temperature to be 70 ℃, controlling the air inlet temperature to be 65-75 ℃, controlling the material temperature to be 35-65 ℃, adjusting the speed of a spray gun to be 150-250 Hz, spraying the angelica sinensis ethanol extract, drying for 5-10 minutes after spraying, controlling the moisture content not to exceed 3 percent to obtain dry granules, and atomizing the wet granules in the process;

step six, particle selection: placing the dry granules into a ternary oscillating screen, and screening and selecting granules;

step seven, mixing finished products: adding the qualified granules selected in the step five into a one-dimensional motion mixer, and mixing for 10 minutes;

Step eight, packaging: and packaging the granules obtained in the sixth step.

Furthermore, the material flows in a closed system during the whole granulation process, and the inside of the closed system is kept at a negative pressure relative to the outside.

further, sterilizing by using a tunnel microwave drying sterilizer in the fourth step.

Further, the screen used in the third step and the fourth step is a 12-mesh screen.

Further, in the fifth step, 10-mesh and 80-mesh screens are selected for sieving operation.

the invention has the beneficial effects that: the process fully extracts the effective components of the angelica, the Chinese date and the astragalus by the first step, particularly the operations of the steps S1 to S4, thereby improving the content of the medicinal components. The raw materials are mixed more uniformly by arranging the high-speed mixing granulator. The wet granulator who sets up and swing formula granulation machine make more even of pelletization to two equipment all sieve the operation after carrying out the pelletization respectively, greatly reduced unqualified wide granule, improved the yield. The particulate extract of the yellow jujube is atomized, granulated and dried by adding to a fluid bed granulator. Compared with the traditional drying equipment, the drying speed of the device is greatly improved, and the loss of effective components caused by overlong drying time in the traditional mode is avoided.

the above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.