阅读说明：本技术 一种脑得生颗粒制备方法 (Preparation method of Naodesheng granules ) 是由 苏学东 李琼 陈文训 胡小桂 于 2019-08-06 设计创作，主要内容包括：本发明公开了一种脑得生颗粒制备方法,通过将三七、川芎、红花、葛根、山楂洗净后干燥,将一半重量份的三七与葛根粉碎成细粉,同时将剩下一半重量份的三七与川芎、红花、山楂打碎；(2)将打碎后的一半重量份三七、川芎、红花、山楂进行煎煮并过滤取得滤液；(3)将步骤(2)中取得的滤液浓缩得浸膏；(4)将步骤(3)中的浸膏干燥成浸膏粉；(5)将三七细粉、葛根细粉与步骤(4)中的浸膏粉混合并同时加入预胶化淀粉和糊精混合均匀,再干燥,整粒过筛；(6)包装。本发明通过打碎三七、川芎、红花、山楂,减少煎煮时间,使本发明在大规模生产时可以节约制作时间,提高生产效率。(The invention discloses a preparation method of Naodesheng granules, which comprises the steps of cleaning pseudo-ginseng, ligusticum wallichii, safflower, kudzu root and hawthorn, drying, crushing half of pseudo-ginseng and kudzu root into fine powder, and crushing the rest half of pseudo-ginseng, ligusticum wallichii, safflower and hawthorn; (2) decocting half of the smashed pseudo-ginseng, ligusticum wallichii, safflower and hawthorn in parts by weight and filtering to obtain filtrate; (3) concentrating the filtrate obtained in the step (2) to obtain an extract; (4) drying the extract obtained in the step (3) into extract powder; (5) mixing the fine powder of radix Notoginseng and the fine powder of radix Puerariae with the extract powder obtained in step (4), adding pregelatinized starch and dextrin, mixing, drying, grading, and sieving; (6) and (6) packaging. According to the invention, the decoction time is reduced by smashing the pseudo-ginseng, the ligusticum wallichii, the safflower and the hawthorn, so that the preparation time can be saved and the production efficiency can be improved during large-scale production.)

1. The preparation method of the Naodesheng granules is characterized by comprising the following raw materials: notoginseng radix, rhizoma Ligustici Chuanxiong, Carthami flos, radix Puerariae, and fructus crataegi, wherein the adjuvants are pregelatinized starch and dextrin.

2. The method for preparing Naodesheng granules according to claim 1, wherein the method comprises the following steps: the process specifically comprises the following steps: (1) cleaning Notoginseng radix, rhizoma Ligustici Chuanxiong, Carthami flos, radix Puerariae and fructus crataegi, drying, pulverizing half weight parts of Notoginseng radix and radix Puerariae into fine powder, and pulverizing the rest half weight parts of Notoginseng radix, rhizoma Ligustici Chuanxiong, Carthami flos and fructus crataegi; (2) decocting half of the smashed pseudo-ginseng, ligusticum wallichii, safflower and hawthorn in parts by weight and filtering to obtain filtrate; (3) concentrating the filtrate obtained in the step (2) to obtain an extract; (4) drying the extract obtained in the step (3) into extract powder; (5) mixing the fine powder of radix Notoginseng and the fine powder of radix Puerariae with the extract powder obtained in step (4), adding pregelatinized starch and dextrin, mixing, drying, grading, and sieving; (6) and (6) packaging.

3. the method for preparing Naodesheng granules according to claim 1, wherein the method comprises the following steps: and (4) concentrating the filtrate in the step (3) until the relative density is 1.22-1.25, wherein the concentration temperature is 80 ℃.

4. The method for preparing Naodesheng granules according to claim 1, wherein the method comprises the following steps: in the step (4), the temperature of the clear paste is kept at about 80 ℃ during spray drying, and the outlet temperature of the dryer is controlled at 90-120 ℃.

5. The method for preparing Naodesheng granules according to claim 1, wherein the method comprises the following steps: in the step (5), the fine pseudo-ginseng powder, the fine kudzu-vine root powder and the extract powder are mixed in a three-dimensional mixer for 30min to obtain the Naodesheng granule extract, and then the Naodesheng granule extract is mixed with pregelatinized starch and dextrin.

6. The method for preparing Naodesheng granules according to claim 1, wherein the method comprises the following steps: in the step (5), the boiling drying agent is used for drying the granules, and when the boiling drying machine is used for drying the granules, the moisture of the granules is controlled to be below 4.0%.

7. The method for preparing Naodesheng granules according to claim 1, wherein the method comprises the following steps: and (3) subpackaging by adopting a particle subpackaging machine in the step (6), wherein the particle subpackaging machine is used for weighing once every 15 minutes when running, and the difference of the filling amount is controlled to be +/-6%.

Technical Field

The invention relates to the field of pharmacy, in particular to a preparation method of Naodesheng granules.

Background

At present, the traditional Chinese medicine for treating cerebral arteriosclerosis, ischemic cerebral apoplexy and cerebral hemorrhage sequelae mainly has the functions of brain regeneration, blood circulation promotion, blood stasis removal and meridian clearing and activating, and is used for treating dizziness and apoplexy caused by blood stasis and collateral obstruction, with symptoms of limb disuse, language handicap, dizziness, cerebral arteriosclerosis, ischemic apoplexy and cerebral hemorrhage sequelae.

Disclosure of Invention

The invention mainly aims to provide a preparation method of Naodesheng granules, and the device reduces the decoction time by crushing pseudo-ginseng, ligusticum wallichii, safflower and hawthorn, so that the preparation time can be saved and the production efficiency can be improved during large-scale production. The invention can effectively solve the problems in the background art.

In order to achieve the purpose, the invention adopts the technical scheme that:

A preparation method of Naodesheng granules comprises the following raw materials: notoginseng radix, rhizoma Ligustici Chuanxiong, Carthami flos, radix Puerariae, and fructus crataegi, wherein the adjuvants are pregelatinized starch and dextrin.

A preparation method of Naodesheng granules comprises the following steps: (1) cleaning Notoginseng radix, rhizoma Ligustici Chuanxiong, Carthami flos, radix Puerariae and fructus crataegi, drying, pulverizing half weight parts of Notoginseng radix and radix Puerariae into fine powder, and pulverizing the rest half weight parts of Notoginseng radix, rhizoma Ligustici Chuanxiong, Carthami flos and fructus crataegi; (2) decocting half of the smashed pseudo-ginseng, ligusticum wallichii, safflower and hawthorn in parts by weight and filtering to obtain filtrate; (3) concentrating the filtrate obtained in the step (2) to obtain an extract; (4) drying the extract obtained in the step (3) into extract powder; (5) mixing the fine powder of radix Notoginseng and the fine powder of radix Puerariae with the extract powder obtained in step (4), adding pregelatinized starch and dextrin, mixing, drying, grading, and sieving; (6) and (6) packaging.

Further, the filtrate in the step (3) is concentrated to the relative density of 1.22-1.25, and the concentration temperature is 80 ℃.

Further, the temperature of the clear paste is kept at about 80 ℃ during spray drying in the step (4), and the outlet temperature of the dryer is controlled at 90-120 ℃.

Further, in the step (5), the fine pseudo-ginseng powder, the fine kudzu-vine root powder and the extract powder are mixed in a three-dimensional mixer for 30min to obtain the Naodesheng granule extract, and then the Naodesheng granule extract is mixed with pregelatinized starch and dextrin.

Furthermore, in the step (5), the granules are dried by using a boiling drying agent, and when the granules are dried by using the boiling drying machine, the moisture content of the granules is controlled to be below 4.0%.

Further, in the step (6), a particle racking machine is adopted for racking, the particle racking machine is weighed once every 15 minutes when in operation, and the loading difference is controlled to be +/-6%.

Has the advantages that: the Naodesheng granules prepared by the invention reduce the decocting time of pseudo-ginseng, ligusticum wallichii, safflower and hawthorn, strictly control the water content of the granules and the difference of the filling amount during packaging, reduce the preparation time and the difference rate during large-scale production and improve the production efficiency.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.