阅读说明：本技术 肉桂醛和/或尿囊素在替代乳仔猪饲料中高锌的应用及饲料添加剂或添加剂预混料、饲料 (Application of cinnamic aldehyde and/or allantoin in replacement of high zinc in piglet feed, feed additive or additive premix and feed ) 是由 周建成 于 2018-06-08 设计创作，主要内容包括：本申请公开肉桂醛和/或尿囊素用于部分替代或全部替代乳仔猪饲料中高锌的应用。本申请还提供一种使用肉桂醛和/或尿囊素部分替代或全部替代高锌的饲料添加剂或添加剂预混料；本申请还提供一种使用上述饲料添加剂或添加剂预混料的乳仔猪饲料。本申请提供的肉桂醛和/或尿囊素的应用、饲料添加剂或添加剂预混料、饲料,可以减少或去除饲料中高锌的使用,同时起到抗拉稀、促进猪生长发育的效果。(the application discloses the use of cinnamaldehyde and/or allantoin to replace partially or totally high zinc in piglet feed. The present application also provides a feed additive or additive premix using cinnamaldehyde and/or allantoin to partially or fully replace high zinc; the application also provides a piglet feed using the feed additive or the additive premix. The application of the cinnamaldehyde and/or allantoin, the feed additive or the additive premix and the feed can reduce or remove the use of high zinc in the feed, and simultaneously have the effects of resisting diarrhea and promoting the growth and development of pigs.)

1. The application of cinnamaldehyde and/or allantoin in partial or complete replacement of high zinc in piglet feed.

2. Use of stabilized cinnamaldehyde and/or allantoin to replace partially or totally high zinc in piglet feed.

3. The feed additive or additive premix for partially replacing high zinc is characterized by comprising 111-1600ppm zinc, and also comprising a composition of 60-5000ppm cinnamic aldehyde and 10-5000ppm allantoin, or any one of 60-5000ppm cinnamic aldehyde and 10-5000ppm allantoin according to the dosage of the complete compound feed.

4. The feed additive or additive premix as defined in claim 3, which further comprises a combination of cinnamic aldehyde in an amount of from 111 to 1600ppm and allantoin in an amount of from 60 to 600ppm, or cinnamic aldehyde in an amount of from 60 to 600ppm, or allantoin in an amount of from 10 to 400ppm, based on the total feed formulation.

5. A feed additive or additive premix for completely replacing high zinc is characterized by comprising a composition of 60-5000ppm of cinnamaldehyde and 10-5000ppm of allantoin, or any one of 60-5000ppm of cinnamaldehyde and 10-5000ppm of allantoin according to the dosage of a complete compound feed.

6. the feed additive or additive premix according to claim 5, which comprises a composition comprising 60 to 600ppm of cinnamaldehyde and 10 to 400ppm of allantoin, or 200 to 600ppm of cinnamaldehyde, or 50 to 400ppm of allantoin, based on the amount of the complete formula feed.

7. The feed additive or additive premix of any of claims 3-6 wherein the cinnamaldehyde is stabilized cinnamaldehyde, specifically any one or more of a coated cinnamaldehyde, a chemically modified cinnamaldehyde, and a chemically modified and then coated cinnamaldehyde.

8. The feed additive or additive premix according to claim 7, wherein the cinnamaldehyde to be coated is in particular cinnamaldehyde coated with a coating material; the chemically modified cinnamaldehyde is cinnamaldehyde obtained by condensing cinnamaldehyde and a compound containing amino or imino; the cinnamaldehyde which is subjected to chemical modification and then coated is cinnamaldehyde which is obtained by condensing cinnamaldehyde and a compound containing amino or imino and then coating with a coating material.

9. The feed additive or additive premix according to claim 8, wherein the amino-or imino-containing compound is selected from the group consisting of chitosan oligosaccharide, chitosan, lysine, methionine, threonine, tryptophan, glycine, aspartic acid, ethylenediamine, astragalus polysaccharides, cysteamine, glutamic acid, glutamine, antimicrobial peptide, thiamine hydrochloride, L-carnitine, DL-carnitine, nicotinamide, ammonium bicarbonate, ammonium dihydrogen phosphate, diammonium hydrogen phosphate, isobutylidene diurea, urea phosphate, ammonium chloride, ammonium alginate, arginine, valine, leucine, isoleucine, methionine hydroxy analogue, tyrosine, taurine, N-carbamyl glutamic acid, histidine, proline, phenylalanine, thiamine nitrate, cysteine, isobutylidene diurea, alginic acid oligosaccharide, nosiheptide, bacitracin zinc, aminopropyl ethoxy amide hydrochloride, Chlorhexadine hydrochloride, dinitrotolamine, methylene salicylic acid bacitracin, xylo-oligosaccharide, oligomeric chitosan, galactomannan oligosaccharide, fructooligosaccharide, mannooligosaccharide, alpha-alanine, N, O-carboxymethyl chitosan oligosaccharide, oligomeric beta- (1,4) -2-amino-2-deoxy-glucose, guanidinoacetic acid, 8-methyl-N-vanillyl-L-nonelamine, capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin I, homodihydrocapsaicin II, nonanephthalein vanillyl amine, octaphthalein vanillyl amine and decanephthal vanillyl amine.

10. The feed additive or additive premix of claim 8 wherein the coating material is selected from the group consisting of cyclodextrin, polyethylene glycol, polyvinyl alcohol, polyacrylic resin, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate, ethyl butyrate succinate, tributyl glycerol, chitosan, pullulan, shellac, polyvinyl alcohol phthalate acetate, cellulose and its derivatives, cellulose acetate phthalate, cellulose acetate 1, 2, 4-benzenetricarboxylate, hydroxypropyl methylcellulose 1, 2, 4-benzenetricarboxylate, cellulose acetate succinate, hydroxypropyl cellulose acetate succinate, methacrylate, methacrylic acid, acrylate, butyl acrylate, ethyl cellulose, triacetin, vinyl propionate, and mixtures thereof, Polyvinyl acetate, polyvinyl butyrate, vinyl carboxylate polymer, vinyl acrylate, a polymer of vinyl pyrrolidone and vinyl carboxylate, a vinyl acrylate polymer, vinyl methacrylate and a polymer thereof, and one or more of ethyl phthalate.

11. A piglet feed comprising the feed additive or additive premix according to any one of claims 3 to 10.

Technical Field

The application relates to the technical field of feed additives, in particular to application of cinnamaldehyde and/or allantoin in replacement of high zinc in piglet feed, a feed additive or additive premix and feed.

Background

In 1989, research of Danish national academy of animal sciences found that adding 2500-4000mg/kg zinc oxide into the daily ration of early weaned piglets can significantly reduce the diarrhea rate of piglets. After that, a large number of researches and production practices prove that the piglet diarrhea can be effectively prevented by adding the high zinc, and the piglet diarrhea prevention method is low in cost and good in economical efficiency. Therefore, in order to ensure that the piglets are safe to wean and do not loose in a large area and die in a large area, most countries including China all add high zinc in the daily ration of the weaned piglets to prevent the piglets from loosing and die and improve the pig raising benefit.

High zinc added into the feed is mainly derived from zinc oxide and basic zinc chloride, so that heavy metal zinc pollution including cadmium pollution accompanying zinc mine is easily caused, and the amount of the added zinc in the feed is reduced by the efforts of various countries. The concentration of zinc in the feed is reduced to 2250ppm from the upper limit of 3000ppm initially allowed to be added, and then to the new regulations to be implemented in China, the concentration of zinc is further reduced to 1600 ppm.

In actual use, however, the weaning feed for the piglets needs to reach the high dosage of zinc oxide 3000-4000 g/ton (namely the zinc content 2250-3000ppm) to obtain the stable anti-rarefaction effect. The upper limit zinc of 1600ppm which is about to be implemented immediately, the diarrhea rate of piglets can reach 6-15 percent and can not meet the market requirement. Therefore, how to reduce the usage amount of zinc in the feed and ensure that the diarrhea rate of piglets is in a control range is an urgent problem to be solved by the technical personnel in the field.

Disclosure of Invention

In order to solve the technical problems, the first object of the invention is to provide an application of cinnamaldehyde and/or allantoin to replace high zinc in piglet feed; the second object of the present invention is to provide a feed additive or additive premix which partially or wholly replaces high zinc with cinnamaldehyde and/or allantoin; the third purpose of the invention is to provide a piglet feed using the feed additive or the additive premix.

The technical scheme provided by the invention is as follows:

The application of cinnamaldehyde and/or allantoin in partial or complete replacement of high zinc in piglet feed.

Use of stabilized cinnamaldehyde and/or allantoin to replace partially or totally high zinc in piglet feed.

A feed additive or additive premix for partially replacing high zinc comprises 1600ppm zinc, and also comprises a composition of 60-5000ppm cinnamic aldehyde and 10-5000ppm allantoin, or any one of 60-5000ppm cinnamic aldehyde or 10-5000ppm allantoin based on the dosage of the complete compound feed.

Preferably, the feed additive or additive premix comprises 111-1600ppm zinc, and further comprises a composition of 60-600ppm cinnamic aldehyde and 10-400ppm allantoin, or any one of 60-600ppm cinnamic aldehyde and 10-400ppm allantoin based on the total compound feed.

A feed additive or additive premix for completely replacing high zinc comprises a composition of 60-5000ppm cinnamic aldehyde and 10-5000ppm allantoin, or any one of 60-5000ppm cinnamic aldehyde and 10-5000ppm allantoin based on the dosage of complete compound feed.

Preferably, the feed additive or additive premix comprises a composition of 60-600ppm cinnamic aldehyde and 10-400ppm allantoin, or 200-600ppm cinnamic aldehyde, or 50-400ppm allantoin, based on the total compound feed.

Preferably, the feed additive or additive premix is prepared by mixing the cinnamaldehyde with a carrier, and adding the mixture into a feed additive or additive premix.

Preferably, the cinnamaldehyde to be coated is particularly cinnamaldehyde obtained by coating with a coating material; the chemically modified cinnamaldehyde is cinnamaldehyde obtained by condensing cinnamaldehyde and a compound containing amino or imino; the cinnamaldehyde which is subjected to chemical modification and then coating treatment is cinnamaldehyde which is obtained by condensing cinnamaldehyde and a compound containing amino or imino and then coating materials.

Preferably, the amino-or imino-containing compound is specifically chitosan oligosaccharide, chitosan, lysine, methionine, threonine, tryptophan, glycine, aspartic acid, ethylenediamine, astragalus polysaccharides, cysteamine, glutamic acid, glutamine, antibacterial peptide, thiamine hydrochloride, L-carnitine, DL-carnitine, nicotinamide, ammonium bicarbonate, ammonium dihydrogen phosphate, diammonium hydrogen phosphate, isobutylidene diurea, urea phosphate, ammonium chloride, ammonium alginate, arginine, valine, leucine, isoleucine, methionine hydroxy analogue, tyrosine, taurine, N-carbamoylglutamic acid, histidine, proline, phenylalanine, thiamine nitrate, cysteine, isobutylidene diurea, alginic acid oligosaccharide, nosiheptide, bacitracin zinc, aminopropyl ethoxyamide hydrochloride, guanidinium chloride, dinitrotolamine, methylene salicylic acid bacitracin, methionine, cysteine, arginine, cysteine, arginine, cysteine, glycine hydrochloride, cysteine, xylo-oligosaccharide, oligochitosan, galactomannan oligosaccharide, fructooligosaccharide, oligomannose, alpha-alanine, N, O-carboxymethyl chitooligosaccharide, oligomeric beta- (1,4) -2-amino-2-deoxy-glucose, guanidinoacetic acid, 8-methyl-N-vanillyl-L-nonelamine, capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin I, homodihydrocapsaicin II, nonanephthalein vanillylamine, octaphthalein vanillylamine and decanephthalein vanillylamine.

Preferably, the coating material is selected from cyclodextrin, polyethylene glycol, polyvinyl alcohol, polyacrylic resin, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate, ethyl butyrate succinate, tributyl glycerol, chitosan, pullulan, shellac, polyvinyl alcohol acetate phthalate, cellulose and derivatives thereof, cellulose acetate phthalate, cellulose acetate 1, 2, 4-benzenetricarboxylate, hydroxypropyl methylcellulose 1, 2, 4-benzenetricarboxylate, cellulose acetate succinate, hydroxypropyl cellulose acetate succinate, methacrylate, methacrylic acid, acrylate, butyl acrylate, acrylic resin, ethyl cellulose, triacetin, vinyl propionate, polyvinyl acetate, polyvinyl butyrate, vinyl carboxylate polymer, polyvinyl acetate, cellulose acetate phthalate, cellulose acetate succinate, cellulose acetate phthalate, polyvinyl acetate, polyvinyl butyrate, polyvinyl acetate polymer, polyvinyl acetate, one or more of vinyl acrylate, a polymer of vinyl pyrrolidone and vinyl carboxylate, a vinyl acrylate polymer, vinyl methacrylate and a polymer thereof and ethyl phthalate.

A piglet feed, which is characterized by comprising the feed additive or the additive premix.

Aiming at the problems in the prior art, the invention provides application of cinnamaldehyde and/or allantoin to replace high zinc in feed.

Cinnamaldehyde has been proposed for preventing feed mildew in the early years, but because cinnamaldehyde is unstable, cinnamaldehyde is not practically applied to feed production to prevent feed mildew, and reports are only limited to test results. In recent years, due to the fact that the demand for antibiotics is higher and higher, the stabilizing technology of cinnamaldehyde is improved to a certain extent, cyclodextrin-coated stabilized cinnamaldehyde is more common in the market at present to replace antibiotics, but the addition amount of cinnamaldehyde is usually lower (less than 60ppm), and cinnamaldehyde and high zinc in the feed are added simultaneously, so that the feed has more stable disease prevention and anti-diarrhea effects. However, no proposal for replacing high zinc with cinnamaldehyde is made. Similarly, no proposal has been made to use allantoin, or to combine cinnamaldehyde with allantoin, instead of high zinc. The feed additive uses the cinnamaldehyde and/or the allantoin to completely or partially replace high zinc, and is added into the feed with sufficient cinnamaldehyde and/or allantoin, so that the feed additive can play a role in resisting diarrhea only by adding zinc (60-110ppm) in an amount required by animal nutrition without adding high zinc.

The cinnamaldehyde can promote release of growth factors of vascular endothelial cells and epithelial cells of the digestive tract mucous membrane, repair the digestive tract mucous membrane which is damaged by sensitizing substances and is not completely developed in feed in time, particularly small intestine chorion, inhibit inflammation and over-expression of inflammation, and simultaneously can directly kill most fungi and protozoa including aspergillus flavus, viruses and bacteria and prevent diarrhea caused by secondary infection after the digestive tract mucous membrane is damaged. Therefore, the cinnamaldehyde can reduce the possibility of damaging the mucous membrane of the digestive tract, particularly the chorion of the small intestine, greatly reduce diarrhea, prevent secondary infection, play a good role in resisting diarrhea and be beneficial to the rapid growth of piglets. The weight gain of piglets fed by using the cinnamaldehyde instead of the high-zinc feed is 12-30% faster in the later stage of nursing and piglet feed stage than that of piglets fed by using the high-zinc daily ration in the early stage, and a new era of the development of the pig industry and the feed industry is created.

Allantoin also has the same function of repairing damaged mucous membrane and chorion as cinnamaldehyde, but it also has a certain astringent effect. Allantoin may therefore also serve as a replacement for high zinc. And the allantoin is used together with the cinnamaldehyde, so that the allantoin has better reinforcing and repairing effects when used as the cinnamaldehyde at low temperature and sudden reduction of air temperature.

The growth of osteoblasts and fibroblasts is hindered due to the fact that the cinnamaldehyde in the feed exceeds a certain dosage, the growth and development of pigs are affected (the growth and development of the pigs are still better than those of a high-zinc group, and the growth and development of the pigs are affected by high zinc in a later period), and the growth promoting and antibacterial effects of the cinnamaldehyde in a proper dosage are not obtained by using the allantoin singly or in a large dosage. Therefore, the proper stabilized cinnamaldehyde can be singly used in seasons with good heat preservation and high temperature to partially or completely replace high zinc, so that the safety can be ensured, and the situations of piglet diarrhea and death which cause the dissatisfaction of breeders can not occur; under the condition of poor heat preservation or lack of an emergency plan of sudden temperature drop, the combination of the cinnamic aldehyde concentration and the allantoin with enough dosage and without influencing (later stage) growth is a better-effect scheme, and can also partially or completely replace high zinc, so that the satisfactory piglet diarrhea rate and the death-free condition of the breeder are obtained, and the adverse effect on later stage development of the piglet is avoided.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present application, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a photograph of 0% diarrhoea from piglets according to example 1 of the present invention;

Fig. 2 is a photograph of 100% diarrhoea of piglets according to example 1 of the present invention.

Detailed Description

In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

As shown in fig. 1 to fig. 2, the technical solution provided by the present invention is as follows:

The application of cinnamaldehyde and/or allantoin in partial or complete replacement of high zinc in piglet feed.

When the piglets are weaned, the feeding of breast milk is changed into the feeding of artificial feed. The feed contains a plurality of anti-nutritional factors such as protease inhibitors, soybean allergenic proteins, soybean trypsin inhibitors, exogenous corrosive phenols and acids, high-dose metal additives, hard crude fibers, lignin, insoluble mineral raw materials and the like, and bacteria, fungi, molds, viruses, protozoa and the like taken along with the feed can damage digestive tract mucous membranes of the piglets in development, particularly intestinal chorions which are not completely developed, further cause inflammation, cause diarrhea of the weaned piglets and cause secondary diseases. The piglet is also an important factor that the weaning period of the piglet is difficult to pass, and the piglet can better resist the adverse factors after the intestinal tract grows completely after the piglet is 65-70 days old.