阅读说明：本技术 稳定的胰岛素制剂 (Stable insulin formulations ) 是由 J·耶热克 D·格林 S·豪威尔 L·扎克热夫斯基 于 2018-05-03 设计创作，主要内容包括：本发明特别涉及含水液体药物制剂,其包含：(i)胰岛素化合物；(ii)锌离子；(iii)浓度为1mM或更高的选自在25℃对锌离子结合而言的logK在4.5-10范围的物质的锌结合物质；(iv)浓度为低于约0.3mM的选自在25℃对锌离子结合而言的logK大于12.3的物质的锌结合物质；和(v)非离子表面活性剂。还提供了相关的方法、用途和药物组合物。(The invention relates in particular to an aqueous liquid pharmaceutical formulation comprising: (i) an insulin compound; (ii) zinc ions; (iii) a zinc binding substance at a concentration of 1mM or more selected from the group consisting of substances having a logK in the range of 4.5-10 for zinc ion binding at 25 ℃; (iv) a zinc binding species selected from the group consisting of species having a logK greater than 12.3 for zinc ion binding at 25 ℃ at a concentration of less than about 0.3 mM; and (v) a nonionic surfactant. Related methods, uses and pharmaceutical compositions are also provided.)