阅读说明：本技术 层叠体、泡罩容器及泡罩包装 (laminate, blister container, and blister package ) 是由 冈本大 鹿岛甲介 伊东亚依 铃木丰明 于 2018-03-12 设计创作，主要内容包括：本发明涉及层叠体、泡罩容器及泡罩包装。更具体而言,本发明涉及一种层叠体、使用了该层叠体的泡罩容器及泡罩包装,所述层叠体依次具有基材层、中间层及氟类树脂层,总膜厚为400μm以下,其特征在于,所述氟类树脂层的厚度为20μm以上150μm以下,所述层叠体的水蒸气透过率为0.5g/m<Sup>2</Sup>/24小时以下。(The present invention relates to a laminate, a blister container and a blister package. More specifically, the present invention relates to a laminate comprising a base material layer, an intermediate layer and a fluorine-based resin layer in this order, the total film thickness of which is 400 μm or less, wherein the thickness of the fluorine-based resin layer is 20 μm or more and 150 μm or less, and the laminate has a water vapor transmission rate of 0.5g/m 2 Less than 24 hours.)

1. A laminate comprising a base material layer, an intermediate layer and a fluorine-based resin layer in this order and having a total film thickness of 400 μm or less,

The fluorine resin layer has a thickness of 20 to 150 [ mu ] m, and the laminate has a water vapor transmission rate of 0.5g/m²Less than 24 hours.

2. The laminate according to claim 1, wherein a second intermediate layer and a second base material layer are further provided in this order on the surface of the fluorine-based resin layer opposite to the surface on which the intermediate layer is formed.

3. The laminate according to claim 1 or 2, wherein the fluorine-based resin layer contains polychlorotrifluoroethylene.

4. The laminate of any one of claims 1 to 3, wherein the laminate has an upper yield stress of 1,500N/cm²The above.

5. The laminate according to any one of claims 1 to 4, wherein the intermediate layer comprises a polyethylene-based resin and a modified polyethylene-based resin.

6. The laminate according to any one of claims 1 to 4, wherein the intermediate layer comprises an acid-modified polyolefin resin, an epoxy group-containing resin, and an elastomer resin.

7. The laminate according to any one of claims 2 to 6, wherein the second intermediate layer comprises a polyethylene-based resin and a modified polyethylene-based resin.

8. The laminate according to any one of claims 2 to 6, wherein the second intermediate layer comprises an acid-modified polyolefin resin, an epoxy group-containing resin, and an elastomer resin.

9. A blister container comprising the laminate according to any one of claims 1 to 8.

10. A blister pack comprising the laminate of any one of claims 1 to 8.

Technical Field

[ CROSS-REFERENCE TO RELATED APPLICATIONS ]

The present application claims the benefit of priority based on japanese patent application No. 2017-053665 filed on 3/17 in 2017, which is incorporated by reference in its entirety in this specification.

[ technical field of the invention ]

The present invention relates to a laminate, a blister container and a blister package.

Background

Film laminates having high barrier properties are used for packaging materials for foods, medicines, and the like. In the pharmaceutical field, blister packs (hereinafter sometimes referred to as "PTP") are used in individual packages of tablets or capsules.

In order to suppress deterioration of the contents, a resin film as a material for forming PTP is required to have barrier properties against water vapor. In addition, since PTP is generally manufactured by drawing, good moldability is required for a resin film as a material for forming PTP. For example, patent documents 1 and 2 describe a laminate in which a fluorine-based resin film is laminated to improve barrier properties against water vapor.

Disclosure of Invention

Technical problem to be solved by the invention

When a laminate having a high water vapor barrier property is produced using a fluorine-based resin having a high barrier property, it is required to provide a laminate having a high barrier property and excellent moldability.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a laminate excellent in moldability, and a blister container and a blister package using the laminate.

Means for solving the problems

That is, the present invention adopts the following configuration.

[1]A laminate comprising a base layer, an intermediate layer and a fluorine-based resin layer in this order and having a total film thickness of 400 [ mu ] m or less, wherein the fluorine-based resin layer has a thickness of 20 [ mu ] m or more and 150 [ mu ] m or less, and the laminate has a water vapor transmission rate of 0.5g/m²Less than 24 hours.

[2] The laminate according to [1], wherein a second intermediate layer and a second base material layer are further provided in this order on a surface of the fluorine-based resin layer opposite to the surface on which the intermediate layer is formed.

[3] The laminate according to [1] or [2], wherein the fluorine-based resin layer contains polychlorotrifluoroethylene.

[4]According to [1]～[3]The laminate of any one of the above, wherein the laminate has an upper yield stress of 1,500N/cm²The above.

[5] The laminate according to any one of [1] to [4], wherein the intermediate layer contains a polyethylene-based resin and a modified polyethylene-based resin.

[6] The laminate according to any one of [1] to [4], wherein the intermediate layer comprises an acid-modified polyolefin resin, an epoxy group-containing resin, and an elastomer resin.

[7] The laminate according to any one of [2] to [6], wherein the second intermediate layer contains a polyethylene-based resin and a modified polyethylene-based resin.

[8] The laminate according to any one of [2] to [6], wherein the second intermediate layer comprises an acid-modified polyolefin resin, an epoxy group-containing resin, and an elastomer resin.

[9] A blister container comprising the laminate according to any one of [1] to [8 ].

[10] A blister pack comprising the laminate according to any one of [1] to [8 ].

Effects of the invention

According to the present invention, a laminate having excellent moldability, and a blister container and a blister package using the laminate can be provided.

Drawings

Fig. 1 is a schematic cross-sectional view of a laminate according to a first embodiment of the present invention.

Fig. 2 is a schematic cross-sectional view of a laminate according to a second embodiment of the present invention.

Detailed Description

The present invention will be described below based on preferred embodiments.

< laminate >

First embodiment

A first embodiment of the laminate according to the present invention will be described with reference to fig. 1.

The laminate 1 of the present embodiment shown in fig. 1 is formed by laminating a base material layer 12, an intermediate layer 10, and a fluororesin layer 11 in this order. The intermediate layer 10 functions as a pressure-sensitive adhesive layer for bonding the fluorine-based resin layer 11 and the base layer 12, and the base layer 12 and the fluorine-based resin layer 11 are laminated via the intermediate layer 10. The thickness of the fluororesin layer 11 is 20 μm to 50 μm.

The laminate 1 of the present embodiment has a three-layer structure of a base material layer 12, an intermediate layer 10, and a fluorine-based resin layer 11. A laminate having a three-layer structure can be produced without complicated steps, and the uniformity of each layer of the laminate is further improved, which is preferable.

The laminate of the present embodiment has a water vapor transmission rate of 0.5g/m²Less than 24 hours, preferably 0.4g/m²Less than 24 hours, more preferably 0.3g/m²Less than 24 hours.

Since the laminate of the present embodiment has a water vapor transmission rate within the above-specified range, it can exhibit high barrier properties and prevent deterioration of the contents, for example, when producing a blister package for pharmaceutical products. In the present embodiment, the water vapor permeability can be controlled by adjusting the material and thickness of each of the base material layer, the fluorine-based resin layer, and the intermediate layer. In the present embodiment, it is particularly preferable to control the water vapor transmission rate within the above-described specific numerical range by adjusting the material and thickness of the fluorine-based resin layer, and it is more preferable to control the water vapor transmission rate by adjusting the thickness of the fluorine-based resin layer.

The upper yield stress of the laminate of the present embodiment measured under the following measurement conditions is preferably 1,500N/cm²Above, more preferably 2,000N/cm²Above, 2,100N/cm is particularly preferable²The above.

By setting the upper yield stress of the laminate to the lower limit or more, the formability during drawing is good. That is, in the drawing, the drawn portion of the laminate becomes convex and a portion extending as compared with the original laminate appears, and if the upper yield point is not less than the lower limit value, the force of returning the drawn portion having become convex to the original shape becomes small, and therefore the formability of the laminate becomes good. This makes it possible to improve the adaptability to, for example, an automatic packaging line.

The upper limit of the upper yield stress is not particularly limited, but can be set to 5,000N/cm by way of example²The following.

The upper yield stress can be controlled by adjusting the material and thickness of each of the base material layer, the fluororesin layer, and the intermediate layer, and in the present embodiment, it is particularly preferable to adjust and control the thickness of the base material layer and the composition of the intermediate layer.

The upper yield stress was measured under the following measurement conditions.

A measuring machine: AUTOGRAPH 100A manufactured by Shimadzu Corporation

The measurement conditions were as follows: JIS K-6732 (tensile Rate: 50mm/min, test temperature: 25 ℃ C.)

Shape and size of test piece: test piece type 5 size based on JIS K-7127

Unit: n/cm²Value measured in accordance with JIS K6732

The layers constituting the present invention will be described below.

[ base Material layer ]

In the present embodiment, the material forming the base layer 12 is any one or more of a polyolefin resin, a polyester resin, and a vinyl resin.

Examples of the polyolefin resin include polyethylene resin, polypropylene resin, and polymethylpentene resin.

Examples of the polyester resin include polyethylene terephthalate, polyethylene naphthalate, polyethylene isophthalate, and polybutylene terephthalate.

Examples of the vinyl resin include polyvinyl acetate resin and polyvinyl chloride resin.

In the present embodiment, a polyester resin is preferable, and polyethylene terephthalate is more preferable.

In the present embodiment, by using any one or more of the above resins for the base material layer 12, for example, in stretch molding, moldability during molding becomes good.

In the present embodiment, the thickness of the base material layer 12 is not particularly limited, and examples thereof include lower limit values of 50 μm or more, 80 μm or more, and 100 μm or more. The upper limit is 250 μm or less, 220 μm or less, or 200 μm or less.

The above upper limit value and lower limit value may be arbitrarily combined.

[ intermediate layer ]

Middle layer (1)

In the present embodiment, an intermediate layer (hereinafter, sometimes referred to as "intermediate layer (1)") comprising a polyethylene resin and a modified polyethylene resin is preferably used as the intermediate layer 10.

Examples of the polyethylene resin include Linear Low Density Polyethylene (LLDPE), Low Density Polyethylene (LDPE), Medium Density Polyethylene (MDPE), and High Density Polyethylene (HDPE), and linear low density polyethylene is preferable.

The modified polyethylene resin is a polyethylene resin modified with an unsaturated carboxylic acid or a derivative thereof, and has an acid functional group such as a carboxyl group or a carboxylic anhydride group in the polyethylene resin. In the present embodiment, a modified polyethylene resin obtained by acid-modifying a polyethylene resin is preferred.

Examples of the acid modification method include graft modification in which a polyethylene resin and an acid functional group-containing monomer are melt-kneaded in the presence of a radical polymerization initiator such as an organic peroxide or an aliphatic azo compound.

The polyethylene resin material before modification is not particularly limited as long as it contains ethylene as a raw material monomer, and a known polyethylene resin can be suitably used. Specifically, examples of the polyethylene resin include, in addition to the above examples, ethylene- α -olefin copolymers such as ethylene-propylene copolymers, ethylene-1-butene copolymers, ethylene-4-methyl-1-pentene copolymers, ethylene-1-hexene copolymers, and ethylene-1-octene copolymers; ethylene copolymer resins such as ethylene-vinyl acetate copolymers, ethylene- (meth) acrylic acid copolymers, and ethylene- (meth) acrylate copolymers.

The acid functional group-containing monomer is a compound having an ethylenic double bond and a carboxyl group or a carboxylic anhydride group in the same molecule, and examples thereof include various unsaturated monocarboxylic acids, dicarboxylic acids, and anhydrides of dicarboxylic acids.

Examples of the acid functional group-containing monomer having a carboxyl group (carboxyl group-containing monomer) include α, β -unsaturated carboxylic acid monomers such as acrylic acid, methacrylic acid, maleic acid, nadic acid (nadic acid), fumaric acid, itaconic acid, citraconic acid, crotonic acid, isocrotonic acid, tetrahydrophthalic acid, endo-bicyclo [2.2.1] hept-5-ene-2, 3-dicarboxylic acid (norbornene diacid)).

Examples of the acid functional group-containing monomer having a carboxylic anhydride group (carboxylic anhydride group-containing monomer) include unsaturated dicarboxylic anhydride monomers such as maleic anhydride, nadic anhydride, itaconic anhydride, citraconic anhydride, and nadic anhydride.

In the component constituting the intermediate layer, these acid functional group-containing monomers may be used singly or in combination of two or more.

Among them, as the acid functional group-containing monomer, acid functional group-containing monomers having an acid anhydride group are preferable, carboxylic acid anhydride group-containing monomers are more preferable, and maleic anhydride is particularly preferable.

When a part of the acid functional group-containing monomer used for acid modification is unreacted, in order to prevent a decrease in adhesive force caused by the unreacted acid functional group-containing monomer, it is preferable to use a substance from which the unreacted acid functional group-containing monomer is removed in advance.

In the present embodiment, the modified polyethylene resin is preferably maleic anhydride modified polyethylene.

In the present embodiment, the lower limit of the ratio of the polyethylene resin to the total mass of the polyethylene resin and the modified polyethylene resin is preferably 10% or more, and more preferably 20% or more, assuming that the total mass of the polyethylene resin and the modified polyethylene resin is 100%. The upper limit of the ratio of the polyethylene resin to the total mass of the polyethylene resin and the modified polyethylene resin is preferably 70% or less, and more preferably 60% or less. For example, the mixing ratio of the polyethylene resin to the modified polyethylene resin may be set to [ polyethylene resin ], [ modified polyethylene resin ], [ 20:80 to 60: 40.

In the present embodiment, the adhesion between the fluororesin layer and the base material layer can be improved by using the intermediate layer (1) using a mixed material of a polyethylene resin and a modified polyethylene resin. Therefore, a laminate in which interlayer peeling is less likely to occur can be provided.

Middle layer (2)

In the present embodiment, an intermediate layer (hereinafter, referred to as "intermediate layer (2)") comprising an acid-modified polyolefin resin, an epoxy group-containing resin, and an elastomer resin is also preferably used as the intermediate layer 10.

Here, each component included in the intermediate layer (2) will be described.

"acid-modified polyolefin resin

The acid-modified polyolefin resin (hereinafter referred to as "component (a)") is a polyolefin resin modified with an unsaturated carboxylic acid or a derivative thereof, and has an acid functional group such as a carboxyl group or a carboxylic acid anhydride group in the polyolefin resin.

(A) The component (B) is obtained by modifying a polyolefin resin with an unsaturated carboxylic acid or a derivative thereof, or by copolymerizing an acid functional group-containing monomer with an olefin. Among them, the polyolefin-based resin is preferably acid-modified as the component (A).

Examples of the acid modification method include graft modification in which a polyolefin resin and an acid functional group-containing monomer are melt-kneaded in the presence of a radical polymerization initiator such as an organic peroxide or an aliphatic azo compound.

Examples of the polyolefin resin include polyethylene, polypropylene, poly-1-butene, polyisobutylene, a random copolymer of propylene and ethylene or an α -olefin, and a block copolymer of propylene and ethylene or an α -olefin. Among these, polypropylene resins such as homopolypropylene (propylene homopolymer; hereinafter, sometimes referred to as "homopolyPP"), a propylene-ethylene block copolymer (hereinafter, sometimes referred to as "block PP"), and a propylene-ethylene random copolymer (hereinafter, sometimes referred to as "random PP") are preferable, and random PP is particularly preferable.

Examples of the olefins to be copolymerized include olefin monomers such as ethylene, propylene, 1-butene, isobutylene, 1-hexene, and α -olefin.

The acid functional group-containing monomer is a compound having an ethylenic double bond and a carboxyl group or a carboxylic anhydride group in the same molecule, and examples thereof include various unsaturated monocarboxylic acids, dicarboxylic acids, and anhydrides of dicarboxylic acids.

Examples of the acid functional group-containing monomer having a carboxyl group (carboxyl group-containing monomer) include α, β -unsaturated carboxylic acid monomers such as acrylic acid, methacrylic acid, maleic acid, nadic acid, fumaric acid, itaconic acid, citraconic acid, crotonic acid, isocrotonic acid, tetrahydrophthalic acid, endo-bicyclo [2.2.1] hept-5-ene-2, 3-dicarboxylic acid (norbornene diacid), and the like.

Examples of the acid functional group-containing monomer having a carboxylic anhydride group (carboxylic anhydride group-containing monomer) include unsaturated dicarboxylic anhydride monomers such as maleic anhydride, nadic anhydride, itaconic anhydride, citraconic anhydride, and nadic anhydride.

In the component (A), these acid functional group-containing monomers may be used singly or in combination of two or more.

Among these, since the acid-functional group-containing monomer has high reactivity with the component (B) described later, the acid-functional group-containing monomer having an acid anhydride group is preferable, the carboxylic acid anhydride group-containing monomer is more preferable, and maleic anhydride is particularly preferable.

When a part of the acid functional group-containing monomer used for acid modification is unreacted, in order to prevent a decrease in adhesive force caused by the unreacted acid functional group-containing monomer, it is preferable to use a substance from which the unreacted acid functional group-containing monomer is removed in advance as the (a) component. Here, "unreacted" means not used for acid modification.

Among these, maleic anhydride-modified polypropylene is preferable as the component (a) from the viewpoint of exhibiting high adhesiveness to the fluororesin layer.

Epoxy group-containing resin

In the present embodiment, the epoxy group-containing resin (hereinafter referred to as "component (B)") is preferably a component having an epoxy group and a vinyl group. The epoxy group-containing resin preferably has a 1, 2-vinyl structure, and more preferably is epoxidized polybutadiene obtained by partially epoxidizing butadiene. Particularly preferred is a product obtained by partially epoxidizing 1, 2-polybutadiene.

Examples of the epoxy group-containing resin that can be used in the present embodiment include liquid polybutadiene of NIPPON SODA CO., LTD.JP-100, and ADK CIZER BF-1000 of JP-200, ADEKA CORPORATION, and the like.

The number average molecular weight of the epoxy group-containing resin is preferably 500 to 4,000.

When the number average molecular weight of the epoxy group-containing resin is not more than the upper limit, the decrease in adhesiveness due to the solid state at room temperature can be suppressed, and the decrease in adhesiveness can be prevented.

The number average molecular weight in the present embodiment is a value in terms of polystyrene measured by GPC (gel permeation chromatography).

Epoxidized polybutadiene is particularly preferably used as the epoxy group-containing resin.

"elastomer resin

The elastomer resin (hereinafter referred to as "component (C)") may be a component having the characteristics as an elastomer, and examples thereof include styrene elastomers, acrylic elastomers, urethane elastomers, olefin elastomers, ester elastomers and the like.

Among them, the olefin-based elastomer is preferable, and for example, a block copolymer having a hard segment composed of polystyrene or the like and a soft segment composed of polyethylene, polybutadiene, polyisoprene or the like is exemplified. Examples of the olefin-based polymer that can be used for the olefin-based elastomer include aromatic olefin-aliphatic olefin copolymers such as styrene-butadiene copolymers, styrene-isoprene copolymers, and styrene-ethylene copolymers.

In the present embodiment, it is preferable that the component (C) is contained in an amount of 1 to 50 parts by mass relative to 50 to 99 parts by mass of the component (a). Among these, it is more preferable to contain 15 to 35 parts by mass of the component (B) with respect to 65 to 85 parts by mass of the component (C).

In the present embodiment, the thickness of the intermediate layer 10 is 5 μm to 50 μm, preferably 10 μm to 30 μm.

In the present embodiment, by setting the thickness of the intermediate layer 10 to be equal to or greater than the lower limit value, adhesion can be improved and interlayer peeling can be prevented. Further, by setting the thickness of the intermediate layer to the upper limit value or less, deterioration of moldability due to thickening can be prevented.

[ fluorine-based resin layer ]

As the fluorine-based resin material used for the fluorine-based resin layer 11, Polytetrafluoroethylene (PTFE), tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer (PFA), tetrafluoroethylene-hexafluoropropylene copolymer (FEP), tetrafluoroethylene-hexafluoropropylene-perfluoroalkyl vinyl Ether (EPA), tetrafluoroethylene-ethylene copolymer (ETFE), polyvinylidene fluoride (PVDF), Polychlorotrifluoroethylene (PCTFE), chlorotrifluoroethylene-Ethylene Copolymer (ECTFE), and a mixture of one or more of these materials can be used, and Polychlorotrifluoroethylene (PCTFE) is preferable.

In the present embodiment, the thickness of the fluororesin layer 11 is 20 μm to 150 μm, preferably 25 μm to 100 μm, and more preferably 30 μm to 50 μm.

In the present embodiment, by setting the thickness of the fluororesin layer 11 to be equal to or greater than the lower limit value, the water vapor transmission rate of the laminate can be reduced, and for example, when used for blister packaging for pharmaceuticals, high moisture resistance can be exhibited, and deterioration of the contents due to water vapor can be prevented.

In the present embodiment, the thickness of the fluororesin layer 11 is set to the upper limit or less, whereby the production cost can be reduced.

Second embodiment

A second embodiment of the laminate according to the present invention will be described with reference to fig. 2.

The laminate 2 of the present embodiment shown in fig. 2 is formed by laminating a base material layer 12, an interlayer 10, a fluororesin layer 11, a second interlayer 13, and a second base material layer 14 in this order.

The laminate 2 having the five-layer structure is preferable because it has high laminate strength. The laminate 2 having a five-layer structure is preferable because curling is less likely to occur.

The materials constituting the base layer, the intermediate layer, and the fluorine-based resin layer in the present embodiment are the same as those described in the first embodiment.

The description of the material constituting the second substrate layer 14 is the same as that of the substrate layer 12. The second substrate layer 14 and the substrate layer 12 may be the same or different in material, and preferably are the same material.

The description of the material constituting the second intermediate layer 13 is the same as that of the intermediate layer 10. The second intermediate layer 13 and the intermediate layer 10 may be the same or different in material, and preferably the same material.

The water vapor transmission rate of the laminate 2 of the present embodiment was 0.5g/m²Less than 24 hours, preferably 0.4g/m²Less than 24 hours, more preferably 0.3g/m²Less than 24 hours.

Since the laminate of the present embodiment has a water vapor transmission rate within the above-specified range, it can exhibit high barrier properties and prevent deterioration of the contents, for example, when producing a blister package for pharmaceutical products.

In the present embodiment, the water vapor permeability of the laminate 2 can be controlled by adjusting the material and thickness of each of the base material layer 12, the intermediate layer 10, the fluororesin layer 11, the second intermediate layer 13, and the second base material layer 14, as in the first embodiment. In the present embodiment, it is particularly preferable to control the water vapor transmission rate within the above-described specific numerical range by adjusting the material and thickness of the fluororesin layer 11, and it is more preferable to control the water vapor transmission rate by adjusting the thickness of the fluororesin layer 11.

The upper yield stress of the laminate of the present embodiment measured under the above-described measurement conditions is preferably 1,500N/cm²Above, more preferably 2,000N/cm²Above, 2,200N/cm is particularly preferable²The above.

By setting the upper yield stress of the laminate to the lower limit or more, the drawability of the laminate is good. Therefore, for example, the adaptability to an automatic packaging line can be improved.

The upper yield stress can be controlled by adjusting the material and thickness of each of the base material layer, the fluororesin layer, and the intermediate layer, and in the present embodiment, it is particularly preferable to control by adjusting the thickness of the base material layer 12 and the second base material layer 14, and the composition of the intermediate layer 10 and the second intermediate layer 13.

In the present embodiment, the material constituting the base material layer 12 may be the same as or different from the material constituting the second base material layer 14, and is preferably made of the same resin material.

The thickness of the second substrate layer 14 relative to the substrate layer 12 is preferably 0.5 to 1.1 times, more preferably 0.9 to 1.1 times, and particularly preferably 0.95 to 1.05 times.

In the present embodiment, the material constituting the intermediate layer 10 may be the same as or different from the material constituting the second intermediate layer 13, and is preferably made of the same resin material.

The thickness of the second intermediate layer 13 relative to the intermediate layer 10 is more preferably 0.9 to 1.1 times, and particularly preferably 0.95 to 1.05 times.

The upper limit of the total film thickness of the laminate of the present invention is 400 μm or less, preferably 300 μm or less. The lower limit of the total film thickness is preferably 80 μm or more, and more preferably 200 μm or more. By setting the film thickness, the contents can be easily protected, and the film can be easily stored and used after molding.

< blister Container, blister Package >

The blister container and the blister package according to the embodiment of the present invention are manufactured by drawing the laminate according to the first or second embodiment of the present invention.

When the laminate 1 according to the first embodiment of the present invention is used, the fluorine-based resin layer 11 may be formed so as to be on the inner side or the outer side, and preferably, so as to be on the outer side.

The blister pack of embodiments of the present invention is for example used for individual packaging of tablets or capsules.

Since the laminate of the present invention has a low water vapor transmission rate, it is possible to prevent deterioration of contents such as tablets and capsules.

The laminate according to the first embodiment of the present invention is preferably produced by melt extrusion molding of a resin as a raw material of the base material layer, a resin as a raw material of the intermediate layer, and a resin as a raw material of the fluororesin layer at the same time.

The laminate of the second embodiment is preferably produced by simultaneously melt-extrusion molding a resin as a raw material of the substrate layer, a resin as a raw material of the intermediate layer, a resin as a raw material of the fluororesin layer, a resin as a raw material of the second intermediate layer, and a resin as a raw material of the second substrate layer.