阅读说明：本技术 一种无毒环保型驱蚊乳剂及其制备方法 (A kind of non-toxic, environmental friendly mosquito repellent emulsion and preparation method thereof ) 是由 袁民政 王春林 仲婕 于 2019-08-12 设计创作，主要内容包括：本发明公开了一种无毒环保型驱蚊乳剂及其制备方法,其中,该无毒环保型驱蚊乳剂由以下原料制备而成：埃卡瑞汀5-20wt％、乳化剂0.05-2.0wt％、助乳化剂0.02-0.1wt％、稳定剂00.05-0.5wt％、防腐抑菌剂0.01-0.1wt％、香料0-0.1wt％、水余量。本发明的有益之处在于：(1)驱蚊安全有效且具有缓释作用,经实验室与野外现场驱蚊试验,证明喷雾或涂抹于皮肤上舒适、无任何不良气味、不刺激皮肤、环境友好,与等浓度的溶液制剂相比较,驱蚊效果更好、持效时间更久,15％的该驱蚊乳剂驱蚊效果与市售20％浓度羟哌酯的溶液制剂几乎相当；(2)有机物总含量仅为1.6-2.9wt％,含水82.0-88.5wt％,一改传统乳剂制备过程中使用有机物量多的模式,使得生产过程绿色环保而又简单、安全,成本大为降低。(The invention discloses a kind of non-toxic, environmental friendly mosquito repellent emulsions and preparation method thereof, wherein, which is prepared from the following materials: Ai Karuiting 5-20wt%, emulsifier 0.05-2.0wt%, assistant for emulsifying agent 0.02-0.1wt%, stabilizer 00.05-0.5wt%, antiseptic and inhibiting bacteria function agent 0.01-0.1wt%, fragrance 0-0.1wt%, water surplus.The invention has the beneficial effects that: (1) mosquito repellent safely and effectively and with slow releasing function, it is tested through laboratory and field condition mosquito repellent, prove it is spraying or be applied on skin it is comfortable, without any bad smell, do not stimulate skin, environmental-friendly, compared with the pharmaceutical solutions of isoconcentration, repelling effect is more preferable, efficiency time is more long, and the 15% mosquito repellent emulsion repelling effect is almost suitable with the pharmaceutical solutions of commercially available 20% concentration Icaridin；(2) total organic content is only 1.6-2.9wt%, aqueous 82.0-88.5wt%, is changed using the mode more than organic object amount in traditional emulsion preparation process, so that production process is environmentally protective and simple, safety, cost is greatly lowered.)

1. a kind of non-toxic, environmental friendly mosquito repellent emulsion, which is characterized in that be prepared from the following materials:

2. non-toxic, environmental friendly mosquito repellent emulsion according to claim 1, which is characterized in that the emulsifier was selected is to spit Temperature, polyvinylpyrrolidone, polyoxyethylene fatty acid ester/ether, PEG rilanit special, soybean lecithin, polyvinyl alcohol and hydroxyl second At least one of base cellulose.

3. non-toxic, environmental friendly mosquito repellent emulsion according to claim 1, which is characterized in that the assistant for emulsifying agent was selected is department At least one of disk, xanthan gum, carbomer and sodium carboxymethylcellulose.

4. non-toxic, environmental friendly mosquito repellent emulsion according to claim 1, which is characterized in that the stabilizer was selected is yin from Sub- surfactant；Preferably, what the anionic surfactant was selected be in Sodium Caprylate, enuatrol and sodium alginate extremely Few one kind.

5. non-toxic, environmental friendly mosquito repellent emulsion according to claim 1, which is characterized in that the antiseptic and inhibiting bacteria function agent is by cinnamic acid Potassium composition, or be made of potassium cinnamate and sodium benzoate.

6. non-toxic, environmental friendly mosquito repellent emulsion according to claim 1, which is characterized in that the antiseptic and inhibiting bacteria function agent is by tea tree Oil, sodium benzoate and parabens composition.

7. non-toxic, environmental friendly mosquito repellent emulsion according to claim 1, which is characterized in that the antiseptic and inhibiting bacteria function agent is by cinnamic acid Potassium and tea oil composition, or be made of potassium cinnamate and parabens.

8. the preparation method of non-toxic, environmental friendly mosquito repellent emulsion described in claim 1 to 5 any one, which is characterized in that including Following steps:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent；

Step2: Ai Karuiting is thrown in the aqueous solution of emulsifier and assistant for emulsifying agent, and stirring is cut into oil-in-water type colostrum；

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion；

Step4: potassium cinnamate and fragrance are thrown in stable oil-in-water emulsion, alternatively, by potassium cinnamate and sodium benzoate And fragrance is thrown in stable oil-in-water emulsion, is stirred to dissolve, then is filtered through squeezing, and it is uniform to obtain particle diameter distribution Oil-in-water type Ai Karuiting lotion.

9. the preparation method of non-toxic, environmental friendly mosquito repellent emulsion as claimed in claim 6, which comprises the following steps:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent；

Step2: Ai Karuiting being mixed with tea oil and parabens and is thrown in the aqueous solution of emulsifier and assistant for emulsifying agent, Stirring is cut into oil-in-water type colostrum；

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion；

Step4: sodium benzoate and fragrance being thrown in stable oil-in-water emulsion, are stirred to dissolve, then are filtered through squeezing, i.e., The uniform oil-in-water type Ai Karuiting lotion of particle diameter distribution is made.

10. the preparation method of non-toxic, environmental friendly mosquito repellent emulsion as claimed in claim 7, which comprises the following steps:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent；

Step2: Ai Karuiting being mixed with tea oil or parabens and is thrown in the aqueous solution of emulsifier and assistant for emulsifying agent, Stirring is cut into oil-in-water type colostrum；

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion；

Step4: potassium cinnamate and fragrance being thrown in stable oil-in-water emulsion, are stirred to dissolve, then are filtered through squeezing, i.e., The uniform oil-in-water type Ai Karuiting lotion of particle diameter distribution is made.

Technical field

The present invention relates to a kind of mosquito repellent emulsions and preparation method thereof, and in particular to a kind of non-toxic, environmental friendly mosquito repellent emulsion and its Preparation method belongs to technical field of chemistry.

Background technique

Ai Karuiting (Icaridin) is called Icaridin, KBR3023, pick up Rui Ting (Picaridin), matches and open up spit of fland (Saltidin), chemical structural formula is as follows:

No. CAS of Ai Karuiting is 119515-38-7, and boiling point is 296 DEG C, for low volatilization, colourless to flaxen clarification Liquid is the mosquito-repellent that Bayer A.G succeeds in developing the nineties in last century, and toxicity is extremely low, Environmental Protection Agency Three-level is regarded as, to no damage to human body, smearing test proves: human skin is only 5% to the absorption of Ai Karuiting, and absorptivity is not To 1/6th (human skin is greater than 30% to the absorptivity of mosquito repellent amine DEET) of gold standard repellant mosquito repellent amine DEET.

Ai Karuiting is small to mosquito, tick (tick worm), biting flies, sand fly, grasshopper worm, sandmite ginger mite insects and mosquito grasshopper class The various insects such as winged insect have wide spectrum repellent action.In mosquito-proof anti-tick sting, the flyproof of 8h, mosquito-proof grasshopper, sand prevention for being up to 14h In mite ginger mite sting comparative experiments, compared with mosquito repellent amine DEET, dimethyl phthalate IR3535, Ai Karuiting is that efficiency time is longest Mosquito-repellent.

Ai Karuiting non-greasy has pleasant low smell, not will cause damage to plastics, synthetic fibers garment type, right For user, deserves to be called a safety, close friend, has effects that the perfect ideal part mosquito-repellent used.Cause This, the selection product that active constituent Ai Karuiting is used as to prevention of malaria is recommended by the World Health Organization (WHO), in global range There is more than 40 country to use the product in registration.

The chemical structural formula of mosquito repellent amine DEET and dimethyl phthalate IR3535 difference are as follows:

2010, someone to the repelling effect of mosquito repellent amine DEET, dimethyl phthalate IR3535, Ai Karuiting these three repellants into Go evaluation study, research is found:

(1) amide groups is the group that three kinds of mosquito repellent compounds have jointly, and the group and compound have with anophelifuge activity It closes；

(2) ester group is the group that dimethyl phthalate IR3535 and Ai Karuiting all have, which, which has compound mosquito repellent, increases Effect effect；

(3) the piperidines cyclic group of the phenyl in mosquito repellent amine DEET and Ai Karuiting have effect to mosquito repellent holding effect；

(4) amide groups, ester group, piperidines cyclic group belong to lipophilic group or have stronger oil-wet behavior, Ai Karuiting Lipophilic group (ester group, piperidine amides base) in chemical structure is to play mosquito repellent and relative to mosquito repellent amine DEET and dimethyl phthalate IR3535 has the main part of more preferable effect.

In the past, Ai Karuiting, the mosquito repellent amine DEET that people used are mostly pharmaceutical solutions, include ethyl alcohol, isopropanol, propylene glycol Or the solubilizer and EDTA etc. such as glycerol, 1,3 butylene glycol, polyvinylpyrrolidone (PVP), PEG rilanit special.In addition to solution Preparation, Ai Karuiting, mosquito repellent amine DEET also have creme, water-in-oil type (W/O) emulsion, gelling agent and paste, these dosage form components Complexity is made of many organic chemicals, produces complexity of getting up to stock up.

Chinese patent CN102266270A discloses a kind of mosquito-repellent, which removes the hydroxyl containing 5-25% Piperazine ester (Ai Karuiting) outside, the also essence of the organic substance containing 10-80%, the organic acid of 0.1-10%, 0.1-1%, surplus For water.Wherein, organic substance includes: ethyl alcohol, isopropanol, citric acid, glycerol, vaseline, cyclodextrin, dimethicone etc..Value It obtains it is noted that when especially with inflammable and explosive ethyl alcohol and isopropanol, easily causing very big life due to using organic solvent Security risk is produced, in addition, crowd's use of susceptible constitution often results in organic matter allergic reaction, some users are using containing alcohols And composite chemical component culicifuge when discovery it is irritating to skin, respiratory tract, and this kind of preparation and organic matter are very not yet It is suitable for children's use.

For water-in-oil type (W/O) although emulsion seldom alcohol-containing type organic, used emulsifier is mostly liposoluble substance, Outer phase medium is fat-soluble organic substance, so there is very big greasy feeling when in use, and easily blocks pore, pollution clothes make Skin lacks refreshing sense of relaxing.Importantly, from the point of view of the molecular structural formula of Ai Karuiting, meeting when water-in-oil emulsion particle ruptures Make hydrophilic segment towards space, and make lipophilic group in Ai Karuiting molecular structure towards application on human skin, when being applied to skin then It is in direct contact with the skin, not only there is certain liposoluble damage and toxic effect to the skin of people, but also be unfavorable for Ai Karuiting Mosquito repellent function part, that is, lipophilic group (ester group, piperidine amides base) in molecular structure plays mosquito repellent function towards space.

Creme, paste, gelling agent, although repelling effect is all well and good, with the presence of sticky thick film after smearing, skin can be produced Raw not well sense, blocks sweat gland, influences cutaneous respiration, it is clear that summer using when be not preferably to select.

Summary of the invention

To solve the deficiencies in the prior art, the purpose of the present invention is to provide it is a kind of using it is pleasant, do not stimulate, safety and hold Long and can effectively mosquito repellent non-toxic, environmental friendly mosquito repellent emulsion and preparation method thereof.

In order to achieve the above objectives, the present invention adopts the following technical scheme that:

A kind of non-toxic, environmental friendly mosquito repellent emulsion, which is characterized in that be prepared from the following materials:

Non-toxic, environmental friendly mosquito repellent emulsion above-mentioned, which is characterized in that aforementioned emulsifier was selected is tween, polyvinyl pyrrole In alkanone, polyoxyethylene fatty acid ester/ether, PEG rilanit special, soybean lecithin, polyvinyl alcohol and hydroxyethyl cellulose It is at least one.

Non-toxic, environmental friendly mosquito repellent emulsion above-mentioned, which is characterized in that aforementioned assistant for emulsifying agent was selected be sapn, xanthan gum, At least one of carbomer and sodium carboxymethylcellulose.

Non-toxic, environmental friendly mosquito repellent emulsion above-mentioned, which is characterized in that aforementioned stabilizer was selected is anion surface active Agent.

Non-toxic, environmental friendly mosquito repellent emulsion above-mentioned, which is characterized in that aforementioned anionic surfactant was selected is octanoic acid At least one of sodium, enuatrol and sodium alginate.

Non-toxic, environmental friendly mosquito repellent emulsion above-mentioned, which is characterized in that aforementioned antiseptic and inhibiting bacteria function agent is made of potassium cinnamate, or It is made of potassium cinnamate and sodium benzoate.

Non-toxic, environmental friendly mosquito repellent emulsion above-mentioned, which is characterized in that aforementioned antiseptic and inhibiting bacteria function agent by tea oil, sodium benzoate and Parabens composition.

Non-toxic, environmental friendly mosquito repellent emulsion above-mentioned, which is characterized in that aforementioned antiseptic and inhibiting bacteria function agent is by potassium cinnamate and tea oil Composition, or be made of potassium cinnamate and parabens.

When antiseptic and inhibiting bacteria function agent is made of potassium cinnamate, the preparation method of non-toxic, environmental friendly mosquito repellent emulsion above-mentioned include with Lower step:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent；

Step2: Ai Karuiting is thrown in the aqueous solution of emulsifier and assistant for emulsifying agent, at the beginning of stirring is cut into oil-in-water type Cream；

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion；

Step4: potassium cinnamate and fragrance being thrown in stable oil-in-water emulsion, are stirred to dissolve, then are filtered through squeezing It crosses, obtains the uniform oil-in-water type Ai Karuiting lotion of particle diameter distribution.

When antiseptic and inhibiting bacteria function agent is made of potassium cinnamate and sodium benzoate, the preparation of non-toxic, environmental friendly mosquito repellent emulsion above-mentioned Method the following steps are included:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent；

Step2: Ai Karuiting is thrown in the aqueous solution of emulsifier and assistant for emulsifying agent, at the beginning of stirring is cut into oil-in-water type Cream；

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion；

Step4: potassium cinnamate and sodium benzoate and fragrance are thrown in stable oil-in-water emulsion, and stirring makes molten Solution, then filtered through squeezing, obtain the uniform oil-in-water type Ai Karuiting lotion of particle diameter distribution.

When antiseptic and inhibiting bacteria function agent is made of tea oil, sodium benzoate and parabens, non-toxic, environmental friendly mosquito repellent above-mentioned The preparation method of emulsion the following steps are included:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent；

Step2: Ai Karuiting is mixed with tea oil and parabens and is thrown in the water-soluble of emulsifier and assistant for emulsifying agent In liquid, stirring is cut into oil-in-water type colostrum；

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion；

Step4: sodium benzoate and fragrance being thrown in stable oil-in-water emulsion, are stirred to dissolve, then are filtered through squeezing It crosses, obtains the uniform oil-in-water type Ai Karuiting lotion of particle diameter distribution.

When antiseptic and inhibiting bacteria function agent is made of potassium cinnamate and tea oil, or is made of potassium cinnamate and parabens, The preparation method of non-toxic, environmental friendly mosquito repellent emulsion above-mentioned the following steps are included:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent；

Step2: Ai Karuiting is mixed with tea oil or parabens and is thrown in the water-soluble of emulsifier and assistant for emulsifying agent In liquid, stirring is cut into oil-in-water type colostrum；

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion；

Step4: potassium cinnamate and fragrance being thrown in stable oil-in-water emulsion, are stirred to dissolve, then are filtered through squeezing It crosses, obtains the uniform oil-in-water type Ai Karuiting lotion of particle diameter distribution.

The invention has the beneficial effects that:

(1) preparation method provided by the invention, production process is environmentally protective and simple, safe, and cost is greatly lowered；

(2) the mosquito repellent emulsion being prepared using preparation method provided by the invention, is oil-in-water type (O/W) emulsion, multiple Chemical bonding, film forming, package, antibacterial technology are closed in one, using film formed in application on human skin be isolated Ai Karuiting with The direct contact of application on human skin, mosquito repellent are tested safely and effectively and with slow releasing function through laboratory and field condition mosquito repellent, it was demonstrated that spray Mist or be applied on skin it is comfortable, without any bad smell, do not stimulate skin, environmental-friendly, the pharmaceutical solutions phase with isoconcentration Compare, repelling effect is more preferable, efficiency time is more long, 15% the mosquito repellent emulsion repelling effect and commercially available 20% concentration Icaridin Pharmaceutical solutions are almost suitable；

(3) in addition to Ai Karuiting principal component, emulsifier used, assistant for emulsifying agent, the amount of stabilizer and bacteriostatic agent are all seldom, have Machine object total content is only 1.6-2.9wt%, aqueous 82.0-88.5wt%, changes and uses organic matter in traditional emulsion preparation process The more mode of amount, so that production process is environmentally protective and simple, safety, cost is greatly lowered, and mosquito repellent emulsion obtained is steady It is fixed, environmentally friendly, do not stimulate skin, without any bad smell, using salubrious, convenient and safe.

Specific embodiment

Technical solution of the present invention is described in further detail below by specific embodiment.

One, raw material

Non-toxic, environmental friendly mosquito repellent emulsion provided by the invention, by Ai Karuiting, emulsifier, assistant for emulsifying agent, stabilizer, anti-corrosion Bacteriostatic agent, fragrance and water are prepared.

1, Ai Karuiting

Ai Karuiting is the main component and effective component of non-toxic, environmental friendly mosquito repellent emulsion provided by the invention, is It is slightly soluble in the substance of water, dosage accounts for 5-20wt%.

2, emulsifier

Emulsifier is from tween, polyvinylpyrrolidone, polyoxyethylene fatty acid ester/ether, PEG rilanit special, soybean ovum It is selected in phosphatide, polyvinyl alcohol and hydroxyethyl cellulose, is cosmetics rank, both can be used alone, can also be appointed Select several be used in mixed way.

This five kinds of emulsifiers of tween, polyvinylpyrrolidone, PEG rilanit special, polyvinyl alcohol, hydroxyethyl cellulose, It is water-soluble substances, it is nontoxic and non-stimulated to skin, it is to select well.

The dosage of emulsifier accounts for 0.05-2.0wt%.

3, assistant for emulsifying agent

Assistant for emulsifying agent is selected from sapn, xanthan gum, carbomer and sodium carboxymethylcellulose, is cosmetics-stage Not, it both can be used alone, optionally several can also be used in mixed way.

These three assistant for emulsifying agents of xanthan gum, carbomer and sodium carboxymethylcellulose, are water-soluble substances, nontoxic and to skin Skin is non-stimulated, is to select well.

The dosage of assistant for emulsifying agent accounts for 0.02-0.1wt%.

After above-mentioned water-soluble emulsifier is mixed with above-mentioned water-soluble assistant for emulsifying agent, when the aqueous solution of mixture is smeared When on skin, skin can feel smooth and comfortable, and without any greasy feeling, the elastic invisible film that will form an exquisiteness after air-drying is attached In on skin, no Uncomfortable feeling, and it is not cutaneous perspire, eupnea and skin remove drawing activity.

The water soluble emulsifier and assistant for emulsifying agent that we select can be cross-linked on application on human skin epidermis as netted invisible film and Make Ai Karuiting is stronger to be attached on film, in addition the hydroxyl in the hydroxyl in emulsifier molecules structure and carboxyl and Ai Karuiting Base is combined with hydrogen bond, simultaneously because package of the oil-in-water emulsion to Ai Karuiting, so that the volatilization of Ai Karuiting escapes change Slow, this allows for the emulsion can also be sustained extension drive while playing quick-acting mosquito-repelling function (Ai Karuiting not wrapped up into) Mosquito acts on (Ai Karuiting that package is entered), extends efficiency time, it is of special importance that the emulsion with concentration compares pharmaceutical solutions Repelling effect is more prominent, efficiency time is longer.

4, stabilizer

Stabilizer is selected from anionic surfactant, and anionic surfactant is from Sodium Caprylate, enuatrol and sodium alginate In selected, both can be used alone, can also optionally several be used in mixed way.

The dosage of stabilizer accounts for 0.05-0.5wt%.

5, antiseptic and inhibiting bacteria function agent

Antiseptic and inhibiting bacteria function agent has multiple choices, specific:

(1) potassium cinnamate is used alone；

(2) potassium cinnamate is used together with sodium benzoate；

(3) potassium cinnamate is used together with tea oil；

(4) potassium cinnamate is used together with parabens

(5) tea oil, sodium benzoate are used together with parabens.

The sylvite of potassium cinnamate system natural cinnamon extract cinnamic acid, since its dissolubility is good, so being widely used in It is novel natural food preservative in medicine, agricultural and food.

Potassium cinnamate also has broad-spectrum antibacterial characteristic, and bacteriostasis is strong, especially to mould, the bacterium for causing food spoilage Very strong with the bacteriostasis of saccharomycete, pressing down mycostatic effective concentration is 0.05-0.1wt%, and general usual amounts are 0.01- 0.02wt%, inhibiting the effective concentration of bacterium is 0.01-0.1wt%, and main inhibition object includes: Pseudomycin category, microballoon Pseudomonas, bacillus, enterobacteriaceae respectively belong to, vibrio, Halobacterium, aerophil, the dry Pseudomonas of cream, lactic acid bacteria, aspergillus flavus Toxin, Escherichia coli, proteus vulgaris, Lactobacillus casei, bacillus amylobacter, lactobacillus plantarum, aerobic spore-bearing bacilli, gram Positive and negative bacillus, clostridium botulinum etc..The antagonistic property of potassium cinnamate is not limited by pH value, pH value antibacterial effect between 2-7 Fruit is all fairly good, and fungistatic effect will not change because of the fluctuation of pH, therefore can be widely used in varieties of food items.

In addition to this, potassium cinnamate also plays stable emulsion.Since potassium cinnamate is by propenyl benzene acid group and potassium structure At, it can be seen that the compound and anionic surfactant such as enuatrol, Sodium Caprylate etc. have structure phase from molecular structural formula As feature, so its stabilizer that can also make oil-in-water emulsion, the parent of anion part (cinnamate anion) Oily group phenyl gos deep into inside emulsion, and acrylic acid radical anion is then exposed to oil-in-water emulsion milk particle surface, by the same sex Repelling each other for charge and make emulsions remained stable.

Tea oil is a kind of natural disinfectant agent, to be colourless to weak yellow liquid, has characteristic perfume and antibacterial, anti-inflammatory, drive The effect of worm, mite killing, is widely used in cosmetics, toilet articles and veterinary product.

Sodium benzoate is the sodium salt of benzoic acid, belongs to acidic preservative, anti-corrosion effect is preferable under acidic environment, is to be in daily use Food preservative, having prevents the rotten effect turned sour, extended the shelf life, it is widely used in various countries in the world.Sodium benzoate Penetrating cell film enters in cell body, by interfering permeability of cell membranes, inhibits absorption of the cell membrane to amino acid, into thin Ionization is acidified intracellular alkali storage in cell space, inhibits the activity of the respiratory enzyme of cell and prevents acetyl-CoA condensation reaction, from And it serves as a food antiseptic.

Parabens are broad-spectrum high efficacy food preservatives generally acknowledged in the world, are widely used in the seasoning such as soy sauce, vinegar The fields such as product and pickled product, bakery, jam product, beverage, yellow rice wine and preserving fruit and vegetable utilizing.Common paraben esters are to hydroxyl Yl benzoic acid methyl esters, ethyl-para-hydroxybenzoate, propylparaben etc., they are used as food preservative.Ni Bo Golden ester makes intracellular protein denaturation, and can inhibit the respiratory enzyme of microbial cell by the cell membrane of destruction microorganism Antibacterial antisepsis is played with the activity of electron transmission enzyme system.Provide parabens preservative single ester in cosmetics Highest limitation is 0.4%, mixed ester 0.8%.Due to it have phenolic hydroxyl structure, so its bacteria resistance can than benzoic acid, Sorbic acid is eager to excel.

The faintly acid preparation that the made mosquito repellent emulsion of the present invention is pH=6-7, needs to press down under weak acid environment using anti-corrosion Microbial inoculum is stablized ensureing it and not corrupt, and potassium cinnamate, sodium benzoate are the anti-of the antibacterial favorable anti-corrosion effect under weak acid environment Rotten bacteriostatic agent, parabens fungistatic effect in the environment of pH=3-8 is best, and tea oil is natural materials, is being played It is not stringent to environment pH requirement when inhibiting bacteria and diminishing inflammation effect, so when potassium cinnamate and tea oil, sodium benzoate, parabens one It rises in use, more complete broad-spectrum antibacterial antisepsis can be played, it is important that they are that lipophilic and hydrophily is antibacterial anti- The optimum organization of rotten agent, parabens and potassium cinnamate are that good lipophilic bacteriostatic preservative and hydrophily are antibacterial anti-respectively Rotten agent, can the mixing with Ai Karuiting of oleophylic is wrapped in emulsion formed in phase, and hydrophilic be then dissolved in water outside milk particle The foreign minister of emulsion is formed with water, while there are also being partially attached to milk particle surface, therefore for oil-in-water emulsion, they Combination plays and forms comprehensive antibacterial antisepsis system from inside to outside, antibacterial favorable anti-corrosion effect, so that obtained cream Agent is stable and will not corruption

Sodium benzoate is water-soluble substances, and the pH range for playing best antibacterial anti-corrosion effect is 2.5-4.0, by itself and tea Tree oil, parabens are used together, for oil-in-water emulsion, since tea oil and parabens can be with Ai Karui Spit of fland is miscible and is typically entrapped within inside milk particle and forms interior phase, and then the antibacterial antisepsis for having had the inside of emulsion；But due to this The system pH=6-7 for inventing institute's antigalactic, has exceeded the best antibacterial anti-corrosion pH range of sodium benzoate, so while sodium benzoate It is water-soluble, but good antibacterial anti-corrosion effect cannot be played in the outside of oil-in-water emulsion, therefore by sodium benzoate Combine that be used together be not optimal selection with tea oil, parabens.

The dosage of antiseptic and inhibiting bacteria function agent accounts for 0.01-0.1wt%.

6, fragrance

Fragrance can select natural lavender essential oil, and dosage accounts for 0-0.1wt%.

Two, preparation method

The method for preparing non-toxic, environmental friendly mosquito repellent emulsion above-mentioned is specific as follows:

Step1: emulsifier is mixed and soluble in water with assistant for emulsifying agent.

Step2: Ai Karuiting is thrown in the aqueous solution of emulsifier and assistant for emulsifying agent, at the beginning of stirring is cut into oil-in-water type Cream.

If what antiseptic and inhibiting bacteria function agent was selected is (3) kind, (4) kind or (5) kind, due to tea oil and parabens All be not readily dissolved in water, thus by Ai Karuiting throw in the aqueous solution of emulsifier and assistant for emulsifying agent when, by tea oil or/ It mixes with parabens with Ai Karuiting and throws in the aqueous solution of emulsifier and assistant for emulsifying agent together, stirring squeezes formation Emulsion is wrapped in Ai Karuiting in milk particle together with tea oil/parabens, increases the interior phase (oil of oil-in-water emulsion Phase) ingredient, but also the interior phase of oil-in-water emulsion more tends to stablize while inside plays antibacterial anti-corrosion effect, and cortex cinnamomi Sour potassium, sodium benzoate are that the interior phase of oil-in-water emulsion and foreign minister are prevented by antibacterial then in the outside of milk particle from inside to outside in this way Rotten agent effect forms a complete antibacterial protective system, thus ensure that emulsion stabilization and will not be corrupt.

Step3: stabilizer is thrown in oil-in-water type colostrum, and stirring forms stable oil-in-water emulsion.

Step4: remaining raw material being thrown in stable oil-in-water emulsion, is stirred to dissolve, then is filtered through squeezing, i.e., The uniform oil-in-water type Ai Karuiting lotion of particle diameter distribution is made.

If what antiseptic and inhibiting bacteria function agent was selected is (1) kind, (3) kind or (4) kind, remaining raw material is cinnamic acid Potassium and fragrance, fragrance can be not added.

If what antiseptic and inhibiting bacteria function agent was selected is (2) kind, remaining raw material is potassium cinnamate, sodium benzoate and perfume (or spice) Material, fragrance can be not added.

If what antiseptic and inhibiting bacteria function agent selected is (5) kind, remaining raw material is sodium benzoate and fragrance, and fragrance can be with It is not added.

The mosquito repellent emulsion being prepared using preparation method provided by the invention is oil-in-water type (O/W) emulsion, not only applied It smears to feel well and relax, tested, spray or be applied to refreshing Shu Chengdu and blank test on skin and (emulsifier and assistant for emulsifying agent are dissolved in water Be prepared into thick cream, then add stabilizer stirring filters pressing and form blank emulsion) almost quite, after air-drying without any greasy feeling and Uncomfortable feeling, and also greatly reduce Ai Karuiting oleophylic mosquito repellent function group and contacted with the direct of application on human skin, reduce toxicity So that lipophilic group is preferably played mosquito repellent function towards space again simultaneously, therefore there is good repelling effect.

It is seldom containing organic object amount since preparation process (produces especially safe) without using alcohols solvent, so drive obtained Mosquito emulsion is non-stimulated, overcomes stimulation of the pharmaceutical solutions to respiratory tract and skin completely.

The emulsion has wrapped up Ai Karuiting, and the lotion being applied on skin is attached on skin at invisible film after air drying, Fixed fasten in the form of hydrogen bond and film is attached to skin surface by Ai Karuiting for hydroxyl and carboxyl in emulsifier and assistant for emulsifying agent, Make its lipophilic group part (mosquito repellent function part) towards space, reduces infiltration of the Ai Karuiting lipophilic group into skin (oleophylic lipophilic substance easily overcomes keratoderma to infiltrate through epidermis) chance, while the volatilization of Ai Karuiting is slowed down again, this Sample can not only more preferably, enduringly play repelling effect, while also reducing infiltration of the Ai Karuiting lipophilic group part to skin Injury, practical mosquito repellent test proves that manufactured emulsion mosquito repellent is safe and efficient, and efficiency time is long.