阅读说明：本技术 抗人***瘤病毒16 e6 t细胞受体 (16 E6 T cell receptor of anti-human papilloma virus (anti-HPV) ) 是由 克里斯蒂安·S·欣里西斯 史蒂文·A·罗森伯格 于 2014-07-14 设计创作，主要内容包括：本发明公开了对人乳头瘤病毒(HPV)16E6,E6<Sub>29-38</Sub>的HLA-A2-限制性表位具有抗原特异性的T细胞受体(TCR)。还提供了相关的多肽和蛋白、以及相关的核酸、重组表达载体、宿主细胞和细胞群体。还提供了与本发明的TCR相关的抗体或其抗原结合部分以及药物组合物。还公开了检测哺乳动物中存在病况的方法以及治疗或预防哺乳动物中病况的方法,其中所述病况为癌症、HPV 16感染或HPV阳性初癌。(The invention discloses to human papilloma virus (HPV) 16E6, E6 29‑38 HLA-A2- restricted epitope have antigentic specificity T cell receptor (TCR).Additionally provide relevant polypeptide and albumen and relevant nucleic acid, recombinant expression carrier, host cell and cell colony.Additionally provide antibody relevant to TCR of the invention or its antigen-binding portion thereof and pharmaceutical composition.Also disclose detection mammal in there are the method for the patient's condition and treat or prevent mammal in the patient's condition method, wherein the patient's condition be cancer, HPV 16 infection or HPV positive precancer.)