Oral care composition and application thereof

文档序号：176721 发布日期：2021-11-02 浏览：39次中文

阅读说明：本技术 一种口腔护理组合物及其应用 (Oral care composition and application thereof ) 是由孙怀庆孙云起苗大娟聂艳峰王娟蒲艳于 2021-08-26 设计创作，主要内容包括：本发明提供了一种口腔护理组合物及其应用,所述口腔护理组合物包括甘草酸二钾、纤连蛋白和乳铁蛋白。本发明提供的口腔护理组合物能够有效清新口气,并能够有效缓解口腔溃疡、牙龈敏感的问题。(The invention provides an oral care composition and application thereof, wherein the oral care composition comprises dipotassium glycyrrhizinate, fibronectin and lactoferrin. The oral care composition provided by the invention can effectively refresh breath and effectively relieve the problems of oral ulcer and gum sensitivity.)

1. An oral care composition comprising dipotassium glycyrrhizinate, fibronectin and lactoferrin.

2. The oral care composition of claim 1, wherein the oral care composition comprises, in parts by weight, dipotassium glycyrrhizinate 0.05-0.5 parts, fibronectin 0.1-1 parts, and lactoferrin 0.5-1.5 parts.

3. The oral care composition according to claim 1 or 2, comprising 0.2-0.4 parts by weight of dipotassium glycyrrhizinate, 0.3-0.7 parts by weight of fibronectin and 0.8-1.2 parts by weight of lactoferrin.

4. Use of an oral care composition according to any one of claims 1 to 3 in the manufacture of an oral care product, wherein the oral care product comprises any one of an oral spray product, a mouthwash or a toothpaste.

5. An oral care product comprising, in parts by weight, 10.6 to 36.5 parts of a sugar alcohol, 0.65 to 3 parts of an oral care composition according to any one of claims 1 to 3, 0.01 to 0.3 part of a cooling agent, and 2 to 10 parts of a stabilizer.

6. The oral care product of claim 5, comprising, in parts by weight, 17.5 to 30 parts of a sugar alcohol, 1.3 to 2.3 parts of the oral care composition of any one of claims 1 to 3, 0.1 to 0.2 part of a cooling agent, and 4 to 8 parts of a stabilizer.

7. The oral care product of claim 5 or 6, wherein the sugar alcohol comprises, in parts by weight, erythritol 0.5-5 parts, xylitol 0.1-1.5 parts, and sorbitol 10-30 parts;

preferably, the sugar alcohol comprises 2-4 parts of erythritol, 0.5-1 part of xylitol and 15-25 parts of sorbitol in parts by weight.

8. The oral care product of any one of claims 5 to 7, wherein the cooling agent comprises menthol and/or menthyl lactate;

preferably, the stabilizer comprises any one or a combination of at least two of propylene glycol, glycerol or absolute ethyl alcohol;

preferably, the oral care product further comprises 0.05 to 0.3 parts by weight of a preservative;

preferably, the preservative comprises sodium benzoate and/or potassium sorbate;

preferably, the oral care product further comprises 0.001-0.01 part by weight of a sweetener;

preferably, the sweetener comprises any one of sucralose, xylitol, sorbitol, or dipotassium glycyrrhizinate, or a combination of at least two of them.

9. A method of making an oral care product according to any one of claims 5 to 8, comprising the steps of:

mixing a sugar alcohol, the oral care composition of any one of claims 1 to 3, and water, and then mixing with a mixed solution of a cooling agent and a stabilizer to obtain the oral care product.

10. The method of making an oral care product according to claim 9, wherein mixing a sugar alcohol, the oral care composition of any one of claims 1-3, and water further comprises mixing with a preservative, a sweetener.

Technical Field

The invention belongs to the field of oral care, and particularly relates to an oral care composition and application thereof, in particular to an oral care composition with a good care effect and application thereof.

Background

In recent years, as the living standard of people is improved, the oral care is also gradually paid attention to the public, and the growing trend of the oral care products is more and more obvious. Oral spray products are enjoyed by more and more people due to the use limitations of toothpaste products and the portability of oral spray products themselves. Most of the commercial oral spray products are only used for refreshing breath, and most of the products contain alcohol preparations, so that the products can stimulate oral mucosa to a certain extent and are not acceptable to some consumers. The needs of most consumers may be to solve the breath problem and to simultaneously alleviate or help to treat other problems occurring in the oral cavity, such as a series of problems including canker sores and periodontal diseases.

CN110859779A discloses an oral care product containing a plant fiber abrasive and a preparation method thereof, wherein the oral care product comprises an abrasive, a thickener and a humectant, the abrasive is plant fiber particles, the thickener comprises xanthan gum, and the humectant comprises polyethylene glycol 1500. The oral care product adopts plant fiber particles to replace the traditional abrasive, and has the characteristics of strong cleaning capability, small damage to teeth, fine and uniform paste and the like.

CN110755298A discloses a lyophilized oral care composition and its application, the raw materials include conventional ingredients and a matrix support agent; the skeleton supporting agent comprises a skeleton supporting agent A component and a skeleton supporting agent B component; the component A of the skeleton supporting agent is a mixture consisting of one or more than one of sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, Arabic gum, xanthan gum and sodium polyacrylate; the component B of the skeleton supporting agent is a mixture consisting of one or more than one of soluble starch, chitosan, wood fiber, mannitol and dextrin. The freeze-dried oral care product prepared from the composition of the scheme has the characteristic of stable tissue form, can be quickly dissolved when meeting water, and has no sticky feeling.

As consumer demands for oral care are increasing. Therefore, how to provide an oral care product capable of alleviating other oral problems becomes a problem to be solved urgently.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide an oral care composition and application thereof, in particular to an oral care composition with good care effect and application thereof. The oral care composition provided by the invention can effectively refresh breath and effectively relieve the problems of oral ulcer and gum sensitivity.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the present invention provides an oral care composition comprising dipotassium glycyrrhizinate, fibronectin and lactoferrin.

The oral care composition can effectively relieve and improve a series of problems of oral ulcer, sensitive gum, periodontal disease and the like by adopting the compounding of the dipotassium glycyrrhizinate, the fibronectin and the lactoferrin and the synergistic effect, and can effectively refresh breath by adopting the freshener.

Preferably, the oral care composition comprises 0.05 to 0.5 part of dipotassium glycyrrhizinate, 0.1 to 1 part of fibronectin and 0.5 to 1.5 parts of lactoferrin by weight.

The amount of dipotassium glycyrrhizinate may be 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc., the amount of fibronectin may be 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, etc., the amount of lactoferrin may be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, etc., but not limited thereto, and any other values not recited in the above-mentioned range are also applicable.

Preferably, the oral care composition comprises 0.2 to 0.4 part of dipotassium glycyrrhizinate, 0.3 to 0.7 part of fibronectin and 0.8 to 1.2 parts of lactoferrin in parts by weight.

The oral care composition with the specific proportion further relieves and improves a series of problems of oral ulcer, gum sensitivity, periodontal disease and the like.

In a second aspect, the present invention provides the use of an oral care composition as described above in the manufacture of an oral care product, wherein the oral care product comprises any one of an oral spray product, a mouthwash or a toothpaste.

The oral spray product can improve the contact area between the product and the oral cavity to a higher extent, is convenient for releasing and acting the effective substances, and has small single-time ingestion of the spray, thereby not giving people a sense of discomfort.

In a third aspect, the present invention provides an oral care product comprising, in parts by weight, 10.6 to 36.5 parts of a sugar alcohol, 0.65 to 3 parts of an oral care composition as described above, 0.01 to 0.3 part of a cooling agent, and 2 to 10 parts of a stabilizer.

The sugar alcohol may be present in an amount of 10.6 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 36.5 parts, etc., the oral care composition may be present in an amount of 0.65 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, or 3 parts, the refreshing agent may be present in an amount of 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, or 0.3 parts, the stabilizer may be present in an amount of 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts, etc., but the above-mentioned ranges are not limited thereto, and other values not listed in the above-mentioned ranges are also applicable.

Preferably, the oral care product comprises 17.5 to 30 parts of sugar alcohol, 1.3 to 2.3 parts of the oral care composition, 0.1 to 0.2 part of cooling agent and 4 to 8 parts of stabilizing agent by weight.

Preferably, the sugar alcohol comprises 0.5-5 parts of erythritol, 0.1-1.5 parts of xylitol and 10-30 parts of sorbitol in parts by weight.

The erythritol may be present in an amount of 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, or 5 parts, xylitol may be present in an amount of 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, or 1.5 parts, and sorbitol may be present in an amount of 10 parts, 15 parts, 20 parts, 25 parts, or 30 parts, but is not limited to the above-mentioned values, and other values not listed in the above-mentioned numerical range are also applicable.

Preferably, the sugar alcohol comprises 2-4 parts of erythritol, 0.5-1 part of xylitol and 15-25 parts of sorbitol in parts by weight.

Preferably, the cooling agent comprises any one of menthol and/or menthol lactate or a combination of at least two thereof.

Preferably, the stabilizer comprises any one of propylene glycol, glycerol or absolute ethyl alcohol or a combination of at least two of the foregoing.

Wherein the stabilizer may be a combination of propylene glycol and glycerin. Combinations of glycerin and absolute ethyl alcohol, or combinations of absolute ethyl alcohol and propylene glycol, and the like, but are not limited to the combinations listed above, and other combinations not listed within the above combination range are also applicable.

Preferably, the oral care product further comprises 0.05 to 0.3 parts by weight of a preservative, such as 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, or 0.3 parts, etc., but not limited to the above-listed values, and other values not listed within the above-mentioned range of values are equally applicable.

Preferably, the preservative comprises sodium benzoate and/or potassium sorbate.

Preferably, the oral care product further comprises 0.001-0.01 parts by weight of a sweetener, such as 0.001 parts, 0.002 parts, 0.003 parts, 0.004 parts, 0.005 parts, 0.006 parts, 0.007 parts, 0.008 parts, 0.009 parts, or 0.01 parts, and the like, but is not limited to the above-listed values, and other values not listed within the above-mentioned range of values are equally applicable.

Preferably, the sweetener includes any one or a combination of at least two of sucralose, xylitol, sorbitol, or dipotassium glycyrrhizinate, such as a combination of sucralose and xylitol, a combination of xylitol and sorbitol, or a combination of sucralose and sorbitol, but is not limited to the above-listed combinations, and other combinations not listed within the above-listed combinations are also applicable.

In a fourth aspect, the present invention also provides a process for the preparation of an oral care product as described above, comprising the steps of:

mixing sugar alcohol, the oral care composition as described above and water, and then mixing with the mixed solution of the cooling agent and the stabilizing agent to obtain the oral care product.

Preferably, mixing the sugar alcohol, oral care composition as described above, and water further comprises mixing with a preservative, sweetener.

Compared with the prior art, the invention has the following beneficial effects:

the invention provides an oral care composition, which can effectively relieve and improve a series of problems of oral ulcer, gingival sensitivity, periodontal disease and the like by adopting the compounding and synergistic effect of dipotassium glycyrrhizinate, fibronectin and lactoferrin, and can effectively refresh breath by adopting a freshener.

Detailed Description

To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

Preparation example 1

The preparation example provides an oral care composition, which comprises the following components in parts by weight:

0.3 part of dipotassium glycyrrhizinate, 0.5 part of fibronectin and 1 part of lactoferrin.

The preparation method comprises the following steps: mixing dipotassium glycyrrhizinate, fibronectin and lactoferrin to obtain the oral care composition.

Preparation example 2

The preparation example provides an oral care composition, which comprises the following components in parts by weight:

0.4 part of dipotassium glycyrrhizinate, 0.3 part of fibronectin and 1.2 parts of lactoferrin.

The preparation method was the same as in preparation example 1.

Preparation example 3

The preparation example provides an oral care composition, which comprises the following components in parts by weight:

0.2 part of dipotassium glycyrrhizinate, 0.7 part of fibronectin and 0.8 part of lactoferrin.

The preparation method was the same as in preparation example 1.

Preparation example 4

The preparation example provides an oral care composition, which comprises the following components in parts by weight:

0.5 part of dipotassium glycyrrhizinate, 0.1 part of fibronectin and 1.5 parts of lactoferrin.

The preparation method was the same as in preparation example 1.

Preparation example 5

The preparation example provides an oral care composition, which comprises the following components in parts by weight:

dipotassium glycyrrhizinate 0.05 part, fibronectin 1 part and lactoferrin 0.5 part.

The preparation method was the same as in preparation example 1.

Comparative preparation example 1

This comparative preparation provides an oral care composition, the composition and proportions of which are identical to those of preparation 1, except that dipotassium glycyrrhizinate is not included, and a reduced proportion is proportionally allocated to fibronectin and lactoferrin.