阅读说明：本技术 柑橘属果实挥发油在制备治疗便秘食品、药品中的应用及其制备的食品、药品 (Application of citrus fruit volatile oil in preparation of food and medicine for treating constipation and food and medicine prepared from citrus fruit volatile oil ) 是由 常瑞欣 吴逸群 杨达 于 2019-06-14 设计创作，主要内容包括：本发明公开了柑橘属果实挥发油在制备调节人体内分泌系统,用于治疗功能性便秘的食品、药品中的应用,其通过抑制前列腺素F<Sub>2α</Sub>分泌、提高前列腺素E<Sub>2</Sub>分泌、降低炎症因子表达水平、提高机体抗氧化能力,调整人体内分泌系统,刺激体内腺体的激素分泌回归正常水平,从而治疗功能性便秘,其使柑橘属果实的果皮得到充分利用,避免资源的浪费,此外可以有效治疗功能性便秘,不再需要临时吃泻药改善便秘。(the invention discloses an application of citrus fruit volatile oil in preparing food and medicine for regulating a human endocrine system and treating functional constipation, which treats the functional constipation by inhibiting secretion of prostaglandin F2 alpha, improving secretion of prostaglandin E2, reducing expression level of inflammatory factors, improving oxidation resistance of organisms, adjusting the human endocrine system and stimulating hormone secretion of glands in vivo to return to a normal level, so that pericarp of citrus fruits is fully utilized, waste of resources is avoided, functional constipation can be effectively treated, and constipation is improved without temporarily taking cathartics.)

1. Application of volatile oil of Citrus fruit in preparing food and medicine for regulating endocrine system of human body and treating functional constipation is provided.

2. Use of a citrus fruit essential oil according to claim 1, characterized in that: the citrus fruit is one or more of sweet orange, fingered citron, Shatian pomelo, grapefruit and kumquat.

3. Use of a citrus fruit essential oil according to claim 1, characterized in that: the method comprises the following steps of cutting pericarp of citrus fruits into pieces, extracting by adopting a steam distillation method, collecting volatile oil, and dehydrating to obtain the citrus fruit volatile oil.

4. Use of a citrus fruit essential oil according to claim 1, characterized in that: the food and the medicine are in the form of capsules, tablets or tabletting candies or gel candies.

5. A food or medicine prepared from volatile oil of citrus fruit, which is characterized in that: including citrus fruit essential oils.

6. Food and pharmaceutical products made from citrus fruit volatile oil according to claim 5, characterized in that: the citrus fruit volatile oil is contained in citrus fruit volatile oil powder oil or citrus fruit volatile oil tablet or coated in edible skin.

7. Food and pharmaceutical products made from citrus fruit volatile oil according to claim 5, characterized in that: also comprises one or more of fillers, lubricants, preservatives, sweeteners, disintegrants, binders, plasticizers, diluents, glidants, colorants, solubilizers, dispersants, wetting agents and surfactants.

8. food and pharmaceutical products made from citrus fruit volatile oil according to claim 7, characterized in that: the filler comprises dextrin, cyclodextrin and starch; the sweetener comprises lactose, xylitol and sorbitol; lubricants include magnesium stearate; the preservative comprises sodium benzoate; the disintegrant comprises hydroxypropyl cellulose; the diluent comprises mannitol, microcrystalline cellulose, lactose, and corn starch; the humectant comprises polysorbate; the plasticizer comprises dimethyl phthalate, diacetin, 1, 2-propylene glycol and glycerol; the surfactant comprises ethanol and propolis.

9. Food and pharmaceutical products made from citrus fruit volatile oil according to claim 5, characterized in that: the medicine consists of the following components: 1-40 parts of citrus fruit volatile oil powder oil, 5-30 parts of cyclodextrin, 5-40 parts of starch, 5-30 parts of dextrin, 5-60 parts of lactose, 5-60 parts of xylitol, 5-60 parts of sorbitol, 0.1-4 parts of magnesium stearate, 0.1-0.2 part of sodium benzoate and 2-10 parts of hydroxypropyl cellulose.

10. Food and pharmaceutical products made from citrus fruit volatile oil according to claim 9, characterized in that: the medicine consists of the following components: 30 parts of citrus fruit volatile oil powder oil, 25 parts of cyclodextrin, 20 parts of starch, 5 parts of dextrin, 10 parts of lactose, 15 parts of xylitol, 15 parts of sorbitol, 0.8 part of magnesium stearate, 0.1 part of sodium benzoate and 5 parts of hydroxypropyl cellulose.

11. Food and pharmaceutical products made from citrus fruit volatile oil according to claim 6, characterized in that: the preparation method of the citrus fruit volatile oil powder oil comprises the following steps: mixing the citrus fruit volatile oil and the starch octenyl succinate solution in proportion, shearing at high speed, homogenizing under high pressure, and spray drying to obtain citrus fruit volatile oil powder oil.

12. Food and pharmaceutical products made from citrus fruit volatile oil according to claim 11, characterized in that: the spray drying conditions are that the air inlet temperature is 190 ℃, the air outlet temperature is 90-100 ℃, the sample injection speed is 30mL/min, and the rotating speed of the centrifugal atomizer is 20000 r/min.

13. Food and pharmaceutical products made from citrus fruit volatile oil according to claim 11, characterized in that: and mixing the citrus fruit volatile oil and the starch octenyl succinate solution according to the mass ratio of 1: 4.

Technical Field

The invention relates to an application of citrus fruit volatile oil in preparation of food and medicines for treating constipation and the prepared food and medicines.

Background

Functional constipation is one of the common digestive system diseases in clinic, and the 2016 roman IV diagnosis standard defines that the number of spontaneous defecation times per week is less than 3, the defecation is hard excrement or dry excrement balls, the defecation is laborious, the defecation is inexhaustible, the anus and rectum are obstructed or blocked when the defecation occurs, and at least 2 items of defecation needs to be assisted by a manipulation, and the diagnosis has no anatomical morphology, nerve and metabolic abnormality. The incidence rate of the functional constipation of infants in China accounts for more than 20% of that of the outpatient clinic of gastrointestinal diseases of infants, the incidence rate of the functional constipation of adults in China is about 4% -6%, the incidence rate of the functional constipation of adults in China gradually increases with the age, and the incidence rate of people over 60 years is up to 22%. Functional constipation not only seriously affects the quality of life of patients, but also induces acute cardiovascular and cerebrovascular diseases and risks of suffering from colon cancer, so that the treatment of functional constipation is very necessary. However, the current methods for treating functional constipation mainly include diet adjustment, lifestyle improvement and laxatives to promote intestinal motility. Laxatives cannot be taken for a long time and only temporarily relieve constipation symptoms, so it is of great importance to develop products that can treat functional constipation without side effects.

At present, citrus plants including fingered citron and sweet orange are widely planted in China, the yield of fingered citron in Jinhua in Zhejiang reaches 400-ton annually, and the fingered citron is mainly used as fingered citron bonsai and fresh fruit for sale, but in recent years, the industrial scale is continuously enlarged, but the market is not enlarged, so that the lost and waste of the fingered citron are caused, more functions of the fingered citron are developed, and the development of fine and deep processing of the fingered citron is promoted, which is particularly important for the fingered citron industry; at present, the yield of sweet oranges in China reaches 700 ten thousand tons, the sweet oranges in the market are mainly eaten as fruits and used for preparing orange juice, most of peels are discarded and not fully utilized, and great resource waste and environmental pollution are caused, so that the intensive deep processing of the sweet oranges is enhanced, the sweet orange resources can be fully utilized, and the continuous development of the sweet orange industry is promoted.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides application of citrus fruit volatile oil in preparing food and medicines for treating constipation and the prepared food and medicines.

The technical scheme adopted by the invention for solving the problems is as follows:

the application of the citrus fruit volatile oil in preparing foods and medicines for regulating the endocrine system of a human body and treating functional constipation finds that the citrus fruit volatile oil can regulate the endocrine system of the human body and stimulate the hormone secretion of glands in the human body to return to a normal level by inhibiting the secretion of prostaglandin F2 alpha, improving the secretion of prostaglandin E2, reducing the expression level of inflammatory factors, improving the oxidation resistance of the organism, and thus has the effect of treating constipation.

Preferably, the citrus fruit is any one or more of sweet orange, finger citron, Shatian pomelo, grapefruit and broad-peel mandarin orange.

Preferably, the citrus fruit is prepared by cutting pericarp of citrus fruit, extracting and collecting volatile oil by steam distillation, and dehydrating to obtain citrus fruit volatile oil.

Preferably, the food or pharmaceutical product is in the form of a capsule, tablet or tabletted or gel-confectionery.

A food or medicine prepared from volatile oil of citrus fruit, which is characterized in that: including citrus fruit essential oils. The food and medicine can be used for regulating endocrine system of human body, and treating functional constipation.

Preferably, the citrus fruit volatile oil is contained in citrus fruit volatile oil powder oil or citrus fruit volatile oil tablets.

preferably, the composition also comprises one or more of a filler, a lubricant, a preservative, a sweetening agent, a disintegrating agent, a binding agent, a plasticizer, a diluent, a glidant, a coloring agent, a solubilizer, a dispersing agent, a wetting agent and a surfactant.

Preferably, the filler comprises dextrin, cyclodextrin and starch; the sweetener comprises lactose, xylitol and sorbitol; lubricants include magnesium stearate; the preservative comprises sodium benzoate; the disintegrant comprises hydroxypropyl cellulose; the diluent comprises mannitol, microcrystalline cellulose, lactose, and corn starch; the humectant comprises polysorbate; the plasticizer comprises dimethyl phthalate, diacetin, 1, 2-propylene glycol and glycerol; the surfactant comprises ethanol and propolis.

Preferably, the medicament consists of the following components: 1-40 parts of citrus fruit volatile oil powder oil, 5-30 parts of cyclodextrin, 5-40 parts of starch, 5-30 parts of dextrin, 5-60 parts of lactose, 5-60 parts of xylitol, 5-60 parts of sorbitol, 0.1-4 parts of magnesium stearate, 0.1-0.2 part of sodium benzoate and 2-10 parts of hydroxypropyl cellulose.

Preferably, the medicament consists of the following components: 30 parts of citrus fruit volatile oil powder oil, 25 parts of cyclodextrin, 20 parts of starch, 5 parts of dextrin, 10 parts of lactose, 15 parts of xylitol, 15 parts of sorbitol, 0.8 part of magnesium stearate, 0.1 part of sodium benzoate and 5 parts of hydroxypropyl cellulose.

Preferably, the preparation process of the citrus fruit volatile oil powder oil is as follows: mixing the citrus fruit volatile oil and the starch octenyl succinate solution in proportion, shearing at high speed, homogenizing under high pressure, and spray drying to obtain citrus fruit volatile oil powder oil.

Preferably, the spray drying conditions are that the air inlet temperature is 190 ℃, the air outlet temperature is 90-100 ℃, the sample injection speed is 30mL/min, and the rotating speed of the centrifugal atomizer is 20000 r/min.

Preferably, the citrus fruit volatile oil and the starch octenyl succinate solution are mixed in a mass ratio of 1: 4.

Compared with the prior art, the invention has the following advantages and effects: the pericarp of citrus fruit is fully utilized, the waste of resources is avoided, functional constipation can be effectively treated, and the constipation can be improved without taking laxatives temporarily.

Detailed Description

The present invention is further illustrated by the following examples, which are illustrative of the present invention and are not to be construed as being limited thereto.