阅读说明：本技术 一种中药膏药组合物及其制备方法 (Traditional Chinese medicine ointment composition and preparation method thereof ) 是由 路传军 于 2019-06-28 设计创作，主要内容包括：本发明涉及中成药及其制备方法技术领域,具体是一种中药膏药组合物及其制备方法。按照质量分数计包括如下物质：桃叶珊瑚苷0.1～90％、京平尼苷0.1～90％、绿源酸0.1～90％、余量为中药基质。本发明的有益效果是,本发明通过在药基质中,加入适量的桃叶珊瑚苷、京平尼苷、绿源酸,将这三种物质的功效有效应用,发挥不同药物的生物活性,安全、无毒副作用、见效快,对女姓疼经缓解效果明显,提高疗效。(The invention relates to the technical field of Chinese patent medicines and preparation methods thereof, in particular to a traditional Chinese medicine ointment composition and a preparation method thereof. The material comprises the following substances in percentage by mass: 0.1-90% of aucubin, 0.1-90% of geniposide, 0.1-90% of chlorogenic acid and the balance of traditional Chinese medicine matrix. The invention has the beneficial effects that the effects of the aucubin, the geniposide and the chlorogenic acid are effectively applied by adding a proper amount of the aucubin, the geniposide and the chlorogenic acid into the medicine matrix, the biological activities of different medicines are exerted, the medicine is safe, has no toxic or side effect, takes effect quickly, has obvious effect of relieving the pain of women surnames, and improves the curative effect.)

1. the traditional Chinese medicine ointment composition is characterized by comprising the following substances in parts by mass:

0.1-90% of aucubin, 0.1-90% of geniposide, 0.1-90% of chlorogenic acid and the balance of traditional Chinese medicine matrix.

2. the traditional Chinese medicine ointment composition as claimed in claim 1, which comprises the following substances in parts by mass:

0.1-20% of aucubin, 0.1-20% of geniposide, 0.1-20% of chlorogenic acid and the balance of plaster matrix.

3. The traditional Chinese medicine ointment composition as claimed in claim 1, which comprises the following substances in parts by mass:

0.1-10% of aucubin, 0.1-10% of geniposide, 0.1-10% of chlorogenic acid and the balance of plaster matrix.

4. a traditional Chinese medicine plaster composition according to any one of claims 1, 2 or 3, wherein the plaster matrix comprises the following substances in parts by weight:

50-150 parts of angelica sinensis, 10-75 parts of ligusticum wallichii, 150-350 parts of red paeony root, 6-200 parts of earthworm, 60-180 parts of pangolin scales, 10-90 parts of monkshood, 10-90 parts of chitsugami and 30-90 parts of camphor.

5. the traditional Chinese medicine plaster composition according to any one of claims 1, 2 or 3, wherein the aucubin is obtained by extracting aucubin with supercritical CO ₂, and the specific method comprises placing aucubin into an extraction kettle under extraction pressure of 20MPa, extraction temperature of 40 deg.C, extraction time of 1h, separation pressure of 6.5MPa, and separation temperature of below 0 deg.C to obtain aucubin.

6. a Chinese medicinal plaster composition according to claim 5, wherein 95% ethanol solution is used as entrainer during the extraction process, and CO ₂ flow rate is 25.0L/h.

7. A process for preparing a traditional Chinese medicine plaster composition according to any one of claims 1 to 6, comprising the steps of:

Pulverizing plaster matrix into powder, cooling to room temperature, adding aucubin, geniposide and chlorogenic acid, mixing, and coating on paper or cloth to obtain plaster.

8. a method of preparing a Chinese medicinal plaster composition according to claim 7, wherein the plaster matrix is prepared by the following steps:

Pulverizing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae Rubra, Lumbricus, squama Manis, radix Aconiti, rhizoma Ligustici Chuanxiong, and Camphora into powder, and making into plaster matrix.

Technical Field

the invention relates to the technical field of Chinese patent medicines and preparation methods thereof, in particular to a traditional Chinese medicine ointment composition and a preparation method thereof.

Background

The existing pain treatment methods mainly comprise oral inflammation diminishing and pain relieving medicines, plaster, massage and the like. But the oral anti-inflammatory analgesic has large side effect, poor physical therapy and massage effects, long-term disunion and prolonged course of disease, and brings great economic burden and mental pain to patients. The existing plaster has poor curative effect, prolongs the course of disease, is not easy to cure and has repeated attack.

disclosure of Invention

the invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine plaster composition which is safe, has no toxic or side effect, takes effect quickly and has obvious effect of relieving pain of a specific part and can be used in cold compress and a preparation method thereof.

In order to achieve the aim, the invention provides a traditional Chinese medicine ointment composition which comprises the following components in parts by mass:

0.1-90% of aucubin, 0.1-90% of geniposide, 0.1-90% of chlorogenic acid and the balance of traditional Chinese medicine matrix.

preferably, the following substances are included in mass fraction:

0.1-20% of aucubin, 0.1-20% of geniposide, 0.1-20% of chlorogenic acid and the balance of plaster matrix.

Preferably, the following substances are included in mass fraction:

0.1-10% of aucubin, 0.1-10% of geniposide, 0.1-10% of chlorogenic acid and the balance of plaster matrix.

Preferably, the plaster matrix comprises the following substances in parts by weight:

50-150 parts of angelica sinensis, 10-75 parts of ligusticum wallichii, 150-350 parts of red paeony root, 6-200 parts of earthworm, 60-180 parts of pangolin scales, 10-90 parts of monkshood, 10-90 parts of chitsugami and 30-90 parts of camphor. The traditional Chinese medicine matrix commonly used in the field can be adopted, and in order to further achieve the effect of relieving pain of a specific part of a female surname, the traditional Chinese medicine matrix comprises the above substances in parts by weight.

Preferably, the aucubin is prepared by extracting aucubin by a supercritical CO ₂ extraction method, and the specific method comprises the following steps of putting the aucubin in an extraction kettle, wherein the extraction pressure is 20MPa, the extraction temperature is 40 ℃, the extraction time is 1h, the separation pressure is 6.5MPa, and the separation temperature is below 0 ℃ to obtain the aucubin, and in order to improve the extraction efficiency in the extraction process of the aucubin and well preserve the active ingredients of the extracted aucubin, the preferred aucubin is prepared by extracting the aucubin by a supercritical CO ₂ extraction method, and the specific method comprises the following steps of putting the aucubin in the extraction kettle, the extraction pressure is 20MPa, the extraction temperature is 40 ℃, the extraction time is 1h, the separation pressure is 6.5MPa, and the separation temperature is below 0 ℃ to obtain the aucubin.

Preferably, ethanol solution with the volume concentration of 95% is used as entrainer in the extraction process, and the flow rate of CO ₂ is 25.0L/h.

The invention also provides a preparation method for preparing the traditional Chinese medicine plaster composition, which comprises the following steps:

Pulverizing plaster matrix into powder, cooling to room temperature, adding aucubin, geniposide and chlorogenic acid, mixing, and coating on paper or cloth to obtain plaster. The plaster can be packaged in sterile cloth to make into pad.

preferably, the plaster matrix is prepared by the following method:

pulverizing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae Rubra, Lumbricus, squama Manis, radix Aconiti, rhizoma Ligustici Chuanxiong, and Camphora into powder, and making into plaster matrix.

In the preparation process, the traditional Chinese medicine is controlled at natural room temperature, and the aucubin, the geniposide and the chlorogenic acid are added and mixed to form the medicine; the influence of high temperature on aucubin, geniposide and chlorogenic acid is avoided, the effective components in the aucubin, the geniposide and the chlorogenic acid are reserved to the maximum extent, the biological activities of different medicines are exerted to the maximum extent, and the curative effect is improved.

the Aucubin (AU) has a chemical name of beta-D-glucopyranoside, is iridoid glycoside compound, and is a secondary metabolite of plants; the aglycone and effective polymer are antibiotics.

Geniposide is an iridoid glucoside, is easily soluble in water, and is the main effective component of fructus Gardeniae. Modern researches show that geniposide has obvious curative effects on diseases of digestive system, cardiovascular system and central nervous system, and has certain anti-inflammatory and soft tissue injury treating effects.

Chlorogenic acid has strong antibacterial and anti-inflammatory effects. Chlorogenic acid contains a special component capable of promoting synthesis and decomposition of collagen in skin, bones and muscles of a human body, has the functions of promoting metabolism and preventing decline, and has a certain curative effect on wound healing, skin health and moisture, joint lubrication, inflammation prevention, balance regulation of blood sugar in vivo and the like because the chlorogenic acid has a special inhibiting effect on hyaluronic acid (HAase) and glucose-6-phosphatase (Gl-6-Pase). Chlorogenic acid has strong inhibiting and killing effects on various diseases and viruses.

the invention has the beneficial effects that the effects of the aucubin, the geniposide and the chlorogenic acid are effectively applied by adding a proper amount of the aucubin, the geniposide and the chlorogenic acid into the medicine matrix, the biological activities of different medicines are exerted, the medicine is safe, has no toxic or side effect, takes effect quickly, has obvious effect of relieving the pain of women surnames, and improves the curative effect.

Detailed Description

The aucubin is extracted by a supercritical CO ₂ extraction method, and the specific method comprises the following steps of putting the anthocarpus sylvestris into an extraction kettle, wherein the extraction pressure is 20MPa, the extraction temperature is 40 ℃, the extraction time is 1h, the separation pressure is 6.5MPa, and the separation temperature is 55 ℃, so that the aucubin is obtained, and in the extraction process, 95% ethanol solution is adopted as an entrainer, and the flow rate of CO2 is 25.0L/h.