阅读说明：本技术 基于复合离子源的质谱分析装置和方法 (Mass spectrometry device and method based on composite ion source ) 是由 陈安琪 甘剑勤 范国正 陈腊 闻路红 于 2021-06-25 设计创作，主要内容包括：本发明提供了基于复合离子源的质谱分析装置和方法,所述基于复合离子源的质谱分析装置包括质谱仪,所述质谱仪具有质谱进样口；第一离子源的第一出口的第一中心轴线与所述质谱进样口的第二中心轴线间的夹角为锐角,所述第一中心轴线不受阻挡地进入所述质谱进样口；所述第一离子源采用电喷雾离子源；第二离子源的第二出口的第三中心轴线与所述第二中心轴线平行,所述第三中心轴线不受阻挡地进入所述质谱进样口；所述第二离子源采用脉冲直流电喷雾离子源；所述第一出口和进样口间的第一距离大于所述第二出口和进样口间的第二距离。本发明实现了多种工作模式的快速切换。(The invention provides a mass spectrometry device and a method based on a composite ion source, wherein the mass spectrometry device based on the composite ion source comprises a mass spectrometer, and the mass spectrometer is provided with a mass spectrometry sample inlet; an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source; a third central axis of a second outlet of a second ion source is parallel to the second central axis, the third central axis entering the mass spectrometry sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet. The invention realizes the quick switching of a plurality of working modes.)

1. A complex ion source based mass spectrometry apparatus comprising a mass spectrometer having a mass spectrometry sample inlet; characterized in that, the mass spectrometry device based on the compound ion source further comprises:

the included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;

a second ion source having a second outlet with a third central axis parallel to the second central axis, the third central axis unobstructed for entry into the mass spectrometry sample inlet; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.

2. The complex ion source-based mass spectrometry apparatus of claim 1, wherein the first and second distances are each greater than 3mm and less than 15 mm.

3. The composite ion source-based mass spectrometry apparatus of claim 1, wherein the first and second central axes intersect, and the third and second central axes are collinear.

4. The complex ion source-based mass spectrometry apparatus of claim 1, further comprising:

the space that the cage enclosed keeps apart with atmospheric environment, mass spectrum introduction port, first ion source and second ion source set up respectively in the cage.

5. The complex ion source-based mass spectrometry apparatus of claim 4, further comprising:

a drawer within which the second ion source is disposed such that the second ion source is within the enclosure and in the atmospheric environment at intervals with the drawer.

6. The complex ion source-based mass spectrometry apparatus of claim 1, further comprising:

a control module to operate the first ion source and the second ion source temporally.

7. The complex ion source-based mass spectrometry apparatus of claim 1, further comprising:

a position sensor for monitoring whether the first and second ion sources are in a set position.

8. The mass spectrometry method based on the complex ion source comprises the following steps:

in an analysis mode of pursuing quantification, only a first ion source works in the composite ion source, an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;

in an analysis mode of pursuing speed, only a second ion source works in the composite ion source, a third central axis of a second outlet of the second ion source is parallel to the second central axis, and the third central axis enters the mass spectrum sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.

9. The method of claim 8, wherein the space enclosed by the enclosure is isolated from the atmosphere, and the mass spectrometer inlet, the first ion source and the second ion source are disposed in the enclosure.

10. The method of claim 9 in which the second ion source is disposed within a drawer such that the second ion source is in an enclosure and in an atmospheric environment at times with the drawer.

Technical Field

The invention relates to mass spectrometry, in particular to a mass spectrometry device and method based on a complex ion source.

Background

The ion source is a key core component of the mass spectrometer, the development of the technology and products thereof continuously pushes the progress of the mass spectrometer and the expansion of the application field, and the invention of a plurality of ionization technologies including the electrospray ion source accelerates the revolution of various subject research fields. The electrospray ion source has better stability and is a key component for quantitative mass spectrometry. The operation of electrospray can be described simply as: under the action of an electric field, the liquid forms a Taylor cone at the tip of the capillary, the liquid drops continuously generate coulomb explosion and are circulated in a reciprocating way, and finally gas-phase ions are obtained. Therefore, electrospray ion sources are a continuous ionization scheme.

Different from a continuous ionization scheme, the pulse direct current electrospray ion source forms an intermittent ionization strategy through a set direct current and alternating current high-voltage control technology to form a pulse gas-phase ion signal, can directly ionize a sample to be detected in an atmospheric pressure environment, and is an ideal means for rapid mass spectrometry.

However, in the conventional mass spectrometer, the switching between the quantitative mass spectrometry and the rapid mass spectrometry depends on the replacement of the ion source, the wiring of the gas circuit and the liquid circuit is complicated, and the process is time-consuming and labor-consuming. The invention provides a composite ion source design, supports quick switching between two sources, has both the quantitative mass spectrometry function of an electrospray ion source and the quick mass spectrometry function of a pulse direct current electrospray ion source, can greatly shorten the operation time of an instrument and obviously improve the mass spectrometry detection efficiency.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention provides a mass spectrometry device based on a composite ion source.

The purpose of the invention is realized by the following technical scheme:

a complex ion source based mass spectrometry apparatus comprising a mass spectrometer having a mass spectrometry sample inlet; the mass spectrometry apparatus based on a complex ion source further comprises:

the included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;

a second ion source having a second outlet with a third central axis parallel to the second central axis, the third central axis unobstructed for entry into the mass spectrometry sample inlet; the second ion source adopts a pulse direct current spray ion source; the first distance between the first outlet and the sample inlet is greater than the second distance between the second outlet and the sample inlet

Another object of the present invention is to provide a method for operating a mass spectrometer based on a complex ion source, which is achieved by the following technical solutions:

the mass spectrometry method based on the complex ion source comprises the following steps:

in an analysis mode of pursuing quantification, only a first ion source works in the composite ion source, an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;

in an analysis mode of pursuing speed, only a second ion source works in the composite ion source, a third central axis of a second outlet of the second ion source is parallel to the second central axis, and the third central axis enters the mass spectrum sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.

Compared with the prior art, the invention has the beneficial effects that:

1. the quantitative and rapid analysis functions are realized;

the composite ion source uses an electrospray ion source and a pulse direct current spray ion source, and has the functions of quantitative mass spectrometry and rapid mass spectrometry;

2. the analysis efficiency is high;

under different working modes, the electrospray ion source and the pulse direct current spray ion source are rapidly switched, if the drawer design is utilized, the pulse direct current spray ion source rapidly enters into work, the operation time of an instrument can be greatly shortened, and the mass spectrum detection efficiency is remarkably improved.

Drawings

The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only for illustrating the technical solutions of the present invention and are not intended to limit the scope of the present invention. In the figure:

fig. 1 is a schematic structural diagram of a mass spectrometry apparatus based on a complex ion source according to an embodiment of the present invention.

Detailed Description

Fig. 1 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. Some conventional aspects have been simplified or omitted for the purpose of explaining the technical solution of the present invention. Those skilled in the art will appreciate that variations or substitutions from these embodiments will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.

Example 1:

fig. 1 is a schematic diagram showing a structure of a complex ion source-based mass spectrometry apparatus according to embodiment 1 of the present invention, and as shown in fig. 1, the complex ion source-based mass spectrometry apparatus includes:

a mass spectrometer having a mass spectrometry sample inlet;

the included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;

a second ion source having a second outlet with a third central axis parallel to the second central axis, the third central axis unobstructed for entry into the mass spectrometry sample inlet; the second ion source adopts a pulse direct current spray ion source; the first distance between the first outlet and the sample inlet is greater than the second distance between the second outlet and the sample inlet, and if the first distance and the second distance are respectively greater than 3mm and less than 15 mm.

To improve the workability, further, the first central axis and the second central axis intersect, and the third central axis and the second central axis are collinear.

In order to prevent the substance to be detected from diffusing into the atmosphere with the airflow, further, the mass spectrometry apparatus further includes:

the space that the cage enclosed keeps apart with atmospheric environment, mass spectrum introduction port, first ion source and second ion source set up respectively in the cage.

In order to shorten the working time, further, the mass spectrometry device further comprises:

a drawer within which the second ion source is disposed such that the second ion source is within the enclosure and in the atmospheric environment at intervals with the drawer.

In order to adjust the operating states of the two ion sources, the mass spectrometer further comprises:

a control module to operate the first ion source and the second ion source temporally.

In order to monitor whether the first ion source, the second ion source and the probe thereof are in the working position, a position sensor is further arranged and used for monitoring whether the first ion source and the second ion source are in the set position.

The mass spectrometry method based on the complex ion source in the embodiment of the present invention, that is, the working method of the mass spectrometry apparatus in the embodiment of the present invention, includes:

in an analysis mode of pursuing quantification, only a first ion source works in the composite ion source, an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;

in an analysis mode of pursuing speed, only a second ion source works in the composite ion source, a third central axis of a second outlet of the second ion source is parallel to the second central axis, and the third central axis enters the mass spectrum sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.

In order to prevent the substance to be detected from diffusing into the atmosphere with the airflow, further, the mass spectrometry apparatus further includes:

the space that the cage enclosed keeps apart with atmospheric environment, mass spectrum introduction port, first ion source and second ion source set up respectively in the cage.

In order to shorten the working time, further, the mass spectrometry device further comprises:

a drawer within which the second ion source is disposed such that the second ion source is within the enclosure and in the atmospheric environment at intervals with the drawer.

Example 2:

an application example of the mass spectrometry apparatus and method based on the complex ion source according to embodiment 1 of the present invention.

In this application example, as shown in fig. 1, the first ion source and the second ion source are disposed in an isolation hood, and the drawer is disposed in the isolation hood, so that when the probe is installed, the second ion source is in an atmospheric environment, and when the probe is installed, the drawer is in the isolation hood;

the first central axis is intersected with the second central axis, the included angle between the first central axis and the second central axis is 60 degrees, the third central axis and the second central axis are collinear, and the first central axis, the second central axis and the third central axis are positioned in the same vertical plane; the first distance is 10mm, and the second distance is 8 mm;

the method comprises the steps that three position monitoring sensors are arranged, each monitoring sensor comprises a light source and a detector, when a monitored object is located at a set position, light emitted by the light source is blocked by the monitored object and cannot enter the detector, when the monitored object is not located at the set position, light emitted by the light source cannot be blocked by the monitored object and enters the detector, and whether the monitored object is installed in place or not is determined according to light intensity received by the detector. In this way, three position monitoring sensors are used to determine whether the probes and drawers of the first ion source, second ion source, respectively, are in place.

A control module for operating the first and second ion sources in time division, rather than simultaneously.

The mass spectrometry method based on the complex ion source in the embodiment of the present invention, that is, the working method of the mass spectrometry apparatus in the embodiment of the present invention, includes:

in an analysis mode of pursuing quantification, only a first ion source works in the composite ion source, an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;

in an analysis mode of pursuing speed, only a second ion source works in the composite ion source, a third central axis of a second outlet of the second ion source is parallel to the second central axis, and the third central axis enters the mass spectrum sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.

In an analysis mode for pursuing speed, the specific steps are as follows:

pulling out a drawer of the pulse direct current spray ion source;

a probe for placing a pulse direct current spray ion source;

closing a drawer of the pulsed direct current spray ion source;

mass spectrometry was initiated.