阅读说明：本技术 一种吡丙醚漂浮粒剂及其制备方法 (Pyriproxyfen floating granule and preparation method thereof ) 是由 冯建国 陈麒丞 钱坤 陈旺 侯超群 王志伟 马英剑 韦诺 于 2020-05-09 设计创作，主要内容包括：本发明公开了农药技术领域内的一种吡丙醚漂浮粒剂及其制备方法,配方按质量百分比组成如下：活性成分1-13%,载体25-37%,分散剂2-8%,润湿剂1-4%,粘结剂5-10%,崩解剂2-12%,填料补足100%。制备时先将农药活性成分、载体、分散剂、润湿剂、崩解剂和粘结剂混合均匀；粉碎后与填料及水混合后加入到捏合机捏合；再经过造粒、干燥、筛分得到漂浮粒剂。本发明漂浮粒剂直接撒施,药剂即可均匀快速分散,降低劳动强度,省时省工；颗粒入水后漂浮在水面,对水体中其他生物不会造成危害,减少污染,更加针对水面漂浮的蚊子卵和幼虫。(The invention discloses a pyriproxyfen floating granule and a preparation method thereof in the technical field of pesticides, wherein the pyriproxyfen floating granule comprises the following components in percentage by mass: 1-13% of active ingredient, 25-37% of carrier, 2-8% of dispersing agent, 1-4% of wetting agent, 5-10% of binder, 2-12% of disintegrating agent and 100% of filler. When in preparation, the pesticide active ingredient, the carrier, the dispersant, the wetting agent, the disintegrant and the binder are mixed uniformly; after being crushed, the mixture is mixed with filler and water and then is added into a kneading machine for kneading; and granulating, drying and screening to obtain the floating granules. The floating granules are directly spread, so that the medicament can be uniformly and quickly dispersed, the labor intensity is reduced, and the time and the labor are saved; the particles float on the water surface after entering the water, do not cause harm to other organisms in the water body, reduce pollution and better aim at the floating mosquito eggs and larvae on the water surface.)

1. The pyriproxyfen floating granule is characterized by comprising the following raw materials in percentage by mass: 1-13% of active ingredient, 25-37% of carrier, 2-8% of dispersing agent, 1-4% of wetting agent, 5-10% of binder, 2-12% of disintegrating agent and 100% of filler.

2. Pyriproxyfen floating granules according to claim 1, characterized in that: the active ingredient is pyriproxyfen.

3. Pyriproxyfen floating granules according to claim 1, characterized in that: the carrier is one or two of expanded perlite, expanded vermiculite, sawmilling powder, aluminum silicate hollow micro-beads and hollow glass micro-beads.

4. Pyriproxyfen floating granules according to claim 1, characterized in that: the dispersant is one or a combination of a plurality of naphthalene sulfonate formaldehyde condensate, carboxylate, calcium lignosulfonate and polycarboxylate.

5. Pyriproxyfen floating granules according to claim 1, characterized in that: the wetting agent is one of a mixture of alkyl naphthalene sulfonate and an anionic wetting agent, sodium lignosulfonate, calcium alkylbenzene sulfonate and an anionic surfactant.

6. Pyriproxyfen floating granules according to claim 1, characterized in that: the binder is one of polyvinylpyrrolidone, polyethylene glycol and gum arabic.

7. Pyriproxyfen floating granules according to claim 1, characterized in that: the disintegrant is urea.

8. Pyriproxyfen floating granules according to claim 1, characterized in that: the filler is one or two of corn starch, white carbon black, potassium chloride and diatomite.

9. A method for preparing pyriproxyfen floating granules according to any one of claims 1 to 8, characterized in that it comprises the following steps:

(1) uniformly mixing the active ingredients, the carrier, the dispersing agent, the disintegrating agent, the binder and the like to form a mixture for later use;

(2) coarsely crushing the mixture obtained in the step 1) and then preparing the mixture into fine powder by using a superfine jet mill;

(3) uniformly mixing the fine powder prepared in the step 2) with the filler, adding a certain amount of water, mixing, and kneading in a kneader;

(4) and after the materials are fully kneaded, the materials are sent into an extrusion granulator for granulation, and finally, the floating granules are obtained through drying and screening.

Technical Field

The invention relates to the technical field of pesticides, and particularly relates to pyriproxyfen floating granules and a preparation method thereof.

Background

Mosquito is one of the important sanitary pests in the world, people not only can generate anaphylactic reaction to cause inflammation and pruritus but also can possibly transmit diseases when being bitten by the mosquito, and the mosquito is known to transmit more than 80 infectious diseases such as dengue fever, Zika virus, yellow fever, Japanese encephalitis and the like, so that the number of death people caused by the mosquito is up to 72.5 thousands of people every year, and therefore, the elimination of the mosquito is the key for ensuring the health of the people and avoiding the transmission of the diseases.

In the actual prevention and treatment process, because adult mosquitoes have a wide range of activity and are relatively difficult to prevent and treat, people try to solve the problem fundamentally by killing young mosquitoes with chemical agents. The traditional pesticide for killing mosquito and young insects mainly comprises organophosphorus pesticides such as chlorpyrifos, parathion, phoxim, fenitrothion and malathion, although the killing effect is obvious, the pesticide is easy to decompose in water, has short residual period and even causes environmental pollution when being used in large amount.

The pyriproxyfen serving as a novel juvenile hormone insecticide has the characteristics of systemic transfer activity, low toxicity, long lasting period, low toxicity to fishes, small influence on ecological environment and the like, and thus the pyriproxyfen becomes an important medicament for mosquito larva prevention and control and is widely concerned by people. At present, the main processing formulations of pyriproxyfen are missible oil, granules, microemulsion, floating granules and the like. The missible oil and the microemulsion use a large amount of organic solvents and emulsifiers, so that the production cost is high, and secondary pollution is easily caused. The floating granules need to be mixed with water for spraying, are inconvenient to use and are not suitable for being applied to mosquito breeding ponds. The granule can sink into water after being applied, the concentration of the insecticide on the water surface is low, and the killing power of mosquito larvae moving on the water surface is reduced. Therefore, for the mosquitoes and children mainly moving on the water bottom and the water surface, the existing pyriproxyfen processing dosage form has the defects of inaccurate pesticide application, low efficiency and the like, and the effective prevention and control of the mosquitoes and the insects from the source is limited to a certain extent.

At present, the published patent application of a single dose of pyriproxyfen is less, and the application patent of publication No. CN 107372517A discloses a pyriproxyfen emulsion granule which needs to be melted at a high temperature and has a main effect of regulating plant growth.

The published application patent on pymetrozine compound is more, and publication No. CN 106818888A discloses an insecticidal composition containing metarhizium anisopliae and pyriproxyfen, in the preparation, diatomite and river sand are used as fillers in the example 2 (granules), the density is large, the sedimentation is easy, the killing power to surface mosquitoes is low, and the pollution to water is caused; the example 3 (aqueous emulsion) and the example 5 (microemulsion) use a large amount of organic solvent, cosolvent and emulsifier, and although the control effect is good, the control cost is not dominant.

The application patent of publication No. CN 106614657A discloses a composition containing pyriproxyfen and matrine, the application patent of publication No. CN 105123699A discloses a composition containing thymol and pyriproxyfen, and the application patent of publication No. CN 102726462A discloses a botanical mosquito larva killing agent containing Duchesnea indica active ingredients, wherein the active ingredients except for the pyriproxyfen are extracts, and the obtaining way is complex and the cost is high.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and/or the prior art, and provides pyriproxyfen floating granules and a preparation method thereof, which can effectively prevent and control anopheles and culex larvae on water surface. Has the characteristics of obvious control effect, time and labor saving and environmental protection.

The purpose of the invention is realized by the following technical scheme: the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: 1-13% of active ingredient, 25-37% of carrier, 2-8% of dispersing agent, 1-4% of wetting agent, 5-10% of binder, 2-12% of disintegrating agent and the balance of filler to 100%.

The active ingredient is pyriproxyfen.

The carrier is one or two of expanded perlite, expanded vermiculite, sawmilling powder, aluminum silicate hollow micro-beads and hollow glass micro-beads.

The dispersant is one or a combination of a plurality of naphthalene sulfonate formaldehyde condensate (D425), carboxylate (D1003), calcium lignosulfonate (Borresperse CaSa) and polycarboxylate (TERSPERSE 2700). The dispersant has the advantages of no toxicity, easy water solubility, good dispersibility and the like.

The wetting agent is one of a mixture of alkyl naphthalene sulfonate and an anionic wetting agent (Morwet EFW), sodium lignosulfonate, calcium alkylbenzene sulfonate and an anionic surfactant (Berol 790A).

The binder is one of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and gum arabic.

The disintegrant is urea.

The filler is one or two of corn starch, white carbon black, potassium chloride and diatomite.

The invention also discloses a preparation method of the pyriproxyfen floating granule, which comprises the following steps:

(1) uniformly mixing the active ingredients, the carrier, the dispersing agent, the disintegrating agent, the binder and the like to form a mixture for later use;

(2) coarsely crushing the mixture obtained in the step 1) and then preparing the mixture into fine powder by using a superfine jet mill;

(3) uniformly mixing the fine powder prepared in the step 2) with the filler, adding a certain amount of water, mixing, and kneading in a kneader;

(4) and after the materials are fully kneaded, the materials are sent into an extrusion granulator for granulation, and finally, the floating granules are obtained through drying and screening.

The invention has the beneficial effects that:

(1) the pyriproxyfen floating granule prepared by the invention does not need to be sprayed or mixed with soil when in use, is directly broadcast and applied, and the medicament can be uniformly dispersed, thereby reducing the labor intensity and saving time and labor;

(2) the pyriproxyfen floating granules prepared by the invention float on the water surface after entering water, more than 90% of active ingredients can be transversely diffused at the water level of the life of mosquitoes, the concentration of effective liquid medicine is ensured, the control drug effect is greatly improved, the aim of accurate pesticide application is achieved, other organisms in the water body are not harmed, and the pollution is reduced.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with examples are described in detail below.

Example 1:

the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: pyriproxyfen: 1% of expanded perlite: 37%, D425: 2%, Morwet EFW: 1%, PVP: 10% and urea: 6% and corn starch to make up 100%.

The preparation method comprises the following specific steps:

1) uniformly mixing the active ingredients, the carrier, the dispersing agent, the disintegrating agent, the binder and the like to form a mixture for later use;

2) coarsely crushing the mixture obtained in the step 1) and then preparing the mixture into fine powder by using a superfine jet mill;

3) uniformly mixing the fine powder prepared in the step 2) with the filler, adding a certain amount of water, mixing, and kneading in a kneader;

4) and after the materials are fully kneaded, the materials are sent into an extrusion granulator for granulation, and finally, the floating granules are obtained through drying and screening.

Example 2:

the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: pyriproxyfen: 3% of expanded vermiculite: 35%, D1003: 4%, sodium lignosulfonate: 2%, polyethylene glycol: 5% and urea: 12% and white carbon black for 100%.

The specific preparation procedure was the same as in example 1.

Example 3:

the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: pyriproxyfen: 5%, sawmilling powder: 33%, Borresperse CaSa: 6%, calcium alkyl benzene sulfonate: 3%, gum arabic: 10% and urea: 10% and potassium chloride to make up 100%.

The specific preparation procedure was the same as in example 1.

Example 4:

the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: pyriproxyfen: 7 percent, aluminum silicate hollow micro-beads: 31%, TERSPERSE 2700: 8%, Berol 790A: 4%, gum arabic: 5% and urea: 8% and diatomite to make up 100%.

The specific preparation procedure was the same as in example 1.

Example 5:

the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: pyriproxyfen: 9% of hollow glass beads: 29%, Borresperse CaSa: 6%, calcium alkyl benzene sulfonate: 3% of polyethylene glycol: 10% and urea: 6% and diatomite to make up 100%.

The specific preparation procedure was the same as in example 1.

Example 6:

the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: pyriproxyfen: 11%, hollow glass beads: 27%, D1003: 4%, sodium lignosulfonate: 2%, PVP: 5% and urea: 4% and potassium chloride to make up 100%.

The specific preparation procedure was the same as in example 1.

Example 7:

the pyriproxyfen floating granule comprises the following raw materials in percentage by mass: pyriproxyfen: 13% of hollow glass beads: 25%, D425: 2%, Morwet EFW: 1%, PVP: 10% and urea: 2 percent and white carbon black for complement to 100 percent.

The specific preparation procedure was the same as in example 1.

The results of the performance tests on the products obtained in the above 7 examples are shown in table 1:

TABLE 1 Floating granule Performance test results

According to test results, the pyriproxyfen floating granule disclosed by the invention is high in suspension rate, good in water surface diffusivity, qualified in heat storage stability and environment-friendly.

Note:

1. and (3) pH value measurement: refer to the assay method of GB/T1601.

2. And (3) suspension rate determination: referring to the measurement method of GB/I14825-2006, the carriers and fillers (hollow glass beads, diatomaceous earth) were removed in the specific measurement.

3. And (3) moisture testing: the distillation was carried out according to "azeotropic distillation" in GB/T1600.

4. Diffusion time: the time in s is measured for the complete diffusion of a suitable amount of sample.

5. Diffusion speed: the distance of diffusion in m/min of a suitable amount of sample is determined in one minute.

6. Heat storage stability: placing a proper amount of sample into a glass bottle, spreading the sample into a smooth and uniform layer, and placing the layer in a constant temperature box (or constant temperature water bath) (54 +/-2) DEG C for 14 days. Then taking out and putting into a dryer, cooling to room temperature, and completing the detection of specified items such as the content of the active ingredients within 24 h.

The present invention is not limited to the above-mentioned embodiments, and based on the technical solutions disclosed in the present invention, those skilled in the art can make some substitutions and modifications to some technical features without creative efforts according to the disclosed technical contents, and these substitutions and modifications are all within the protection scope of the present invention.