阅读说明：本技术 一种治疗甲状腺炎的中药组合物及其制备方法 (Traditional Chinese medicine composition for treating thyroiditis and preparation method thereof ) 是由 王高力 彭延宽 彭丽萍 王雯 于 2021-07-28 设计创作，主要内容包括：本发明公开一种治疗甲状腺炎的中药组合物及其制备方法,涉及中药技术领域。其中,所述中药组合物包括以下组分：代赭石、海浮石、青礞石、黄芩、酒大黄、白芥子、肉桂、白芍和沉香。代赭石、海浮石和青礞石起清火平肝、降逆化痰的作用,黄芩、酒大黄起清热泻火的作用,白芍起凉血养血活血的作用,沉香其降气化痰、除滞的作用,白芥子起化痰散结的作用,肉桂用于反佐诸药之过寒,如此,所述中药组合物通过上述原料组分的协同作用,以清热泻火、化痰散结的方法,起到消肿散结的作用,且能降低血清中甲状腺炎的抗体,从而使该中药组合物对桥本氏甲状腺炎具有良好的治疗效果。(The invention discloses a traditional Chinese medicine composition for treating thyroiditis and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. Wherein, the traditional Chinese medicine composition comprises the following components: haematitum, Pumex, lapis Chloriti, Scutellariae radix, radix et rhizoma Rhei, semen Sinapis Albae, cortex Cinnamomi, radix Paeoniae alba and lignum Aquilariae Resinatum. The ruddle, the pumice and the lapis chlorite have the effects of clearing fire, calming the liver, lowering adverse qi and reducing phlegm, the scutellaria baicalensis and the wine-treated rhubarb have the effects of clearing heat and purging fire, the white paeony root has the effects of cooling blood, nourishing blood and activating blood, the agilawood has the effects of lowering qi, reducing phlegm and removing stagnation, the white mustard seed has the effects of dissolving phlegm and dissipating stagnation, and the cinnamon is used for assisting the excessive cold of the medicines.)

1. A traditional Chinese medicine composition for treating thyroiditis is characterized by comprising the following components:

haematitum, Pumex, lapis Chloriti, Scutellariae radix, radix et rhizoma Rhei, semen Sinapis Albae, cortex Cinnamomi, radix Paeoniae alba and lignum Aquilariae Resinatum.

2. The traditional Chinese medicine composition for treating thyroiditis as claimed in claim 1, wherein the Haematitum, the Pumex, the lapis Chloriti, the Scutellaria baicalensis, the wine-processed rhubarb, the white mustard seed, the cinnamon, the white peony root and the agilawood are respectively in parts by weight: 20-30 parts of ruddle, 10-20 parts of pumice, 20-40 parts of lapis chlorite, 150-200 parts of scutellaria baicalensis, 150-200 parts of wine-treated rhubarb, 20-30 parts of white mustard seed, 10-20 parts of cinnamon, 30-50 parts of white paeony root and 10-20 parts of agilawood.

3. The traditional Chinese medicine composition for treating thyroiditis as claimed in claim 2, wherein the Haematitum, the Pumex, the lapis Chloriti, the Scutellaria baicalensis, the wine-processed rhubarb, the white mustard seed, the cinnamon, the white peony root and the agilawood are respectively in parts by weight: 25 parts of ruddle, 15 parts of pumice, 30 parts of lapis chlorite, 170 parts of scutellaria baicalensis, 170 parts of wine-treated rhubarb, 25 parts of semen brassicae, 15 parts of cinnamon, 40 parts of white paeony root and 15 parts of agilawood.

4. The traditional Chinese medicine composition for treating thyroiditis as claimed in claim 1, wherein the dosage form of the traditional Chinese medicine composition is tablet, granule, pill, capsule or powder.

5. The traditional Chinese medicine composition for treating thyroiditis of claim 1, wherein the traditional Chinese medicine composition further comprises pharmaceutically acceptable excipients.

6. A method for preparing the traditional Chinese medicine composition for treating thyroiditis as claimed in any one of claims 1 to 3, comprising the following steps:

cleaning and drying raw materials in the Chinese patent medicine, wherein the raw materials comprise ochre, bryozoatum, lapis Chloriti, radix scutellariae, wine-processed rhubarb, semen brassicae, cinnamon, radix paeoniae alba and agilawood;

and (3) crushing and sieving the dried raw materials, and then uniformly mixing to obtain the traditional Chinese medicine composition.

7. The method for preparing a traditional Chinese medicine composition for treating thyroiditis as claimed in claim 6, wherein the drying temperature of the drying is 50-70 ℃ so that the moisture of the dried raw materials is 5-15%.

8. The preparation method of the traditional Chinese medicine composition for treating thyroiditis as claimed in claim 6, wherein the sieving is 100-300 mesh sieving.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating thyroiditis and a preparation method thereof.

Background

Hashimoto's thyroiditis is one of chronic lymphocytic thyroiditis, an autoimmune disease, and is mainly characterized by massive lymphocyte infiltration in thyroid gland tissues and massive antithyroid antibody in serum, and clinically manifested by large thyroid swelling, hard texture and reduced function.

At present, Western medicine adopts palliative treatment because no effective treatment method is available for Hashimoto's thyroiditis, namely thyroiditis is not treated, Youme is taken for the whole life after hypothyroidism appears, and thyromegaly is finally removed by operation; in traditional Chinese medicine, no effective prescription for treating hashimoto's thyroiditis is available at present.

Disclosure of Invention

The invention mainly aims to provide a traditional Chinese medicine composition for treating thyroiditis and a preparation method thereof, and aims to provide a traditional Chinese medicine composition with a good treatment effect on thyroiditis.

In order to achieve the aim, the invention provides a traditional Chinese medicine composition for treating thyroiditis, which comprises the following components:

haematitum, Pumex, lapis Chloriti, Scutellariae radix, radix et rhizoma Rhei, semen Sinapis Albae, cortex Cinnamomi, radix Paeoniae alba and lignum Aquilariae Resinatum.

Optionally, the ruddle, the bryozoatum, the lapis chlorite, the scutellaria baicalensis, the wine-processed rhubarb, the white mustard seed, the cinnamon, the white paeony root and the agilawood are respectively in parts by weight: 20-30 parts of ruddle, 10-20 parts of pumice, 20-40 parts of lapis chlorite, 150-200 parts of scutellaria baicalensis, 150-200 parts of wine-treated rhubarb, 20-30 parts of white mustard seed, 10-20 parts of cinnamon, 30-50 parts of white paeony root and 10-20 parts of agilawood.

Optionally, the ruddle, the bryozoatum, the lapis chlorite, the scutellaria baicalensis, the wine-processed rhubarb, the white mustard seed, the cinnamon, the white paeony root and the agilawood are respectively in parts by weight: 25 parts of ruddle, 15 parts of pumice, 30 parts of lapis chlorite, 170 parts of scutellaria baicalensis, 170 parts of wine-treated rhubarb, 25 parts of semen brassicae, 15 parts of cinnamon, 40 parts of white paeony root and 15 parts of agilawood.

Optionally, the dosage form of the traditional Chinese medicine composition is tablets, granules, pills, capsules or powder.

Optionally, the traditional Chinese medicine composition further comprises pharmaceutically acceptable auxiliary materials.

The invention also provides a preparation method of the traditional Chinese medicine composition for treating thyroiditis, which comprises the following steps:

cleaning and drying raw materials in the Chinese patent medicine, wherein the raw materials comprise ochre, bryozoatum, lapis Chloriti, radix scutellariae, wine-processed rhubarb, semen brassicae, cinnamon, radix paeoniae alba and agilawood;

and (3) crushing and sieving the dried raw materials, and then uniformly mixing to obtain the traditional Chinese medicine composition.

Optionally, the drying temperature of the drying is 50-70 ℃, so that the moisture of the dried raw material is 5-15%.

Optionally, the sieving is to sieve through 100-300 meshes.

In the technical scheme provided by the invention, the traditional Chinese medicine composition for treating thyroiditis is prepared by taking ruddle, bryozoatum, lapis Chloriti, Scutellaria baicalensis, wine-processed rhubarb, semen brassicae, cinnamon, white paeony root and agilawood as raw materials, wherein, the ruddle, the bryozoatum and the lapis chlorite have the functions of clearing fire, calming the liver, lowering adverse qi and reducing phlegm, the baikal skullcap root and the wine rhubarb have the functions of clearing heat and purging fire, the white paeony root has the functions of cooling blood, nourishing blood and activating blood, the agilawood has the functions of lowering qi, reducing phlegm and removing stagnancy, the white mustard seed has the functions of reducing phlegm and resolving masses, and the cinnamon is used for assisting the excessive cold of the medicines, so the traditional Chinese medicine composition has the synergistic effect of the raw material components, has the functions of reducing swelling and resolving masses by clearing heat and purging fire, reducing phlegm and resolving masses, and can reduce the antibody of thyroiditis in serum, therefore, the traditional Chinese medicine composition has good treatment effect on hashimoto's thyroiditis and no side effect.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that those whose specific conditions are not specified in the examples were performed according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially. In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B" including either A or B or both A and B. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

At present, Western medicine adopts palliative treatment because no effective treatment method is available for Hashimoto's thyroiditis, namely thyroiditis is not treated, Youme is taken for the whole life after hypothyroidism appears, and thyromegaly is finally removed by operation; in traditional Chinese medicine, no effective prescription for treating hashimoto's thyroiditis is available at present.

In view of this, the invention provides a traditional Chinese medicine composition for treating thyroiditis, and aims to provide a traditional Chinese medicine composition with a good treatment effect on hashimoto's thyroiditis. In one embodiment, the traditional Chinese medicine composition comprises the following components: haematitum, Pumex, lapis Chloriti, Scutellariae radix, radix et rhizoma Rhei, semen Sinapis Albae, cortex Cinnamomi, radix Paeoniae alba and lignum Aquilariae Resinatum.

Haematitum, bitter and sweet in taste, slightly cold in nature; entering liver, stomach and heart meridians; has effects of suppressing hyperactive liver, subsiding yang, lowering adverse qi, cooling blood, and stopping bleeding; can be used for treating headache, vertigo, palpitation, mania, epilepsy, emesis, belch, singultus, dysphagia, cough, asthma, hematemesis, epistaxis, metrorrhagia, hematochezia, and hematuria.

Pumice, salty in taste, cold in nature; it enters lung, kidney, liver and large intestine meridians; has effects in clearing lung-heat, eliminating phlegm, softening and resolving hard mass; can be used for treating cough due to lung heat, thick and yellow phlegm, hemoptysis, bronchitis, and lymphoid tuberculosis.

Lapis Chloriti, sweet, salty, neutral in nature; entering lung, heart and liver meridians; has effects in eliminating phlegm, lowering qi, calming liver, and relieving convulsion; it can be used for treating intractable phlegm, cough, asthma, epilepsy, dysphoria, chest distress, convulsion, etc.

Scutellaria, bitter in taste and cold in nature; it enters lung, gallbladder, spleen, stomach, large intestine and small intestine meridians; has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage; it can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness, jaundice, dysentery, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, and sore.

Rhubarb wine, bitter taste and cold nature; spleen, stomach, large intestine, liver, heart meridian entered; has the effects of removing food retention, removing food stagnation, purging pathogenic fire, cooling blood, removing blood stasis, and dredging channels; it can be used for treating constipation, constipation due to heat accumulation, intense heat with yellow tongue coating, excessive fire heat, hematemesis, epistaxis, conjunctival congestion, sudden pain, pyocutaneous disease due to heat toxin, blood stasis, and jaundice due to damp-heat.

White peony root, bitter and sour in taste, slightly cold in nature; entering liver and spleen meridians; has effects in nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang; can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm and pain, headache, and vertigo.

Chen Xiang is pungent and bitter in flavor and slightly warm in nature; spleen, stomach and kidney meridians entered; has effects in promoting qi circulation, relieving pain, warming middle warmer, relieving vomit, and promoting inspiration and relieving asthma; it can be used for treating chest and abdomen distention, pain, stomach cold, emesis, singultus, deficiency of the kidney, reversed flow of qi, and dyspnea.

White mustard seed, pungent in flavor and warm in nature; it enters liver, spleen, lung, stomach, heart and uterus meridians; has the effects of eliminating phlegm, resolving masses and relieving swelling; it can be used for treating cough, asthma, excessive phlegm, chest fullness, hypochondriac pain, numbness of limbs, arthralgia, damp phlegm, abscess, dorsal furuncle, and toxic swelling. .

Cinnamon, pungent and sweet in flavor, with great heat in nature; entering kidney, spleen, heart and liver meridians; has the effects of nourishing fire, supporting yang, guiding fire to the origin, dispelling cold, relieving pain, and warming and dredging channels and collaterals; can be used for treating sexual impotence, cold womb, lumbago, knee psychroalgia, asthma due to kidney deficiency, floating of deficient yang, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.

Through years of clinical practice of the inventor, the hashimoto's thyroiditis is summarized as phlegm-fire coagulation, and in the technical scheme provided by the invention, the traditional Chinese medicine composition for treating thyroiditis is prepared by taking ruddle, bryozoatum, lapis Chloriti, scutellaria baicalensis, wine-processed rhubarb, semen brassicae, cinnamon, radix paeoniae alba and agilawood as raw materials, wherein the ruddle, the bryozoatum and the lapis Chloriti play roles in clearing fire and calming the liver and reducing adverse-rising energy and resolving phlegm, the scutellaria baicalensis and the wine-processed rhubarb play roles in clearing heat and purging fire, the radix paeoniae alba plays roles in cooling blood and nourishing blood and activating blood, the agilawood plays roles in reducing qi and resolving phlegm and removing stagnation, the semen brassicae plays roles in dissolving phlegm and resolving masses, and the cinnamon is used for assisting excessive cold of various medicines, so the traditional Chinese medicine composition plays roles in clearing heat and resolving phlegm and resolving masses through the synergistic effect of the raw material components, and can reduce antibodies of thyroiditis in serum, and accordingly the traditional Chinese medicine composition has a good treatment effect on the hashimoto thyroiditis, and has no side effect.

The invention does not limit the mixture ratio of the components of the traditional Chinese medicine composition, and the optimal raw material mixture ratio (in parts by mass) of the traditional Chinese medicine composition is obtained through years of continuous practice and summary analysis of the inventor: 20-30 parts of ruddle, 10-20 parts of pumice, 20-40 parts of lapis chlorite, 150-200 parts of scutellaria baicalensis, 150-200 parts of wine-treated rhubarb, 20-30 parts of white mustard seed, 10-20 parts of cinnamon, 30-50 parts of white paeony root and 10-20 parts of agilawood. Practice proves that when the raw materials of the traditional Chinese medicine composition are within the mass range, the traditional Chinese medicine composition has good curative effect on hashimoto's thyroiditis.

Further, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 25 parts of ruddle, 15 parts of bryozoatum, 30 parts of lapis chlorite, 170 parts of scutellaria baicalensis, 170 parts of wine-treated rhubarb, 25 parts of semen brassicae, 15 parts of cinnamon, 40 parts of white paeony root and 15 parts of agilawood, and the traditional Chinese medicine composition has the best treatment effect on hashimoto thyroiditis.

The invention does not limit the use mode of the traditional Chinese medicine composition as long as the traditional Chinese medicine composition comprises the raw material components. However, the operation of the traditional Chinese medicine decoction is troublesome when in use, which brings inconvenience to patients, and therefore, in this embodiment, the traditional Chinese medicine composition is mainly used in the form of a Chinese patent medicine. The Chinese medicinal composition is in the dosage form of tablets, granules, pills, capsules or powder.

In one embodiment, the traditional Chinese medicine composition further comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials can be a flavoring agent and can also be materials used in a preparation process, such as an adhesive used in a pill preparation process, and the adhesive can be honey or rice paste.

In order to save the time for preparing the traditional Chinese medicine composition and facilitate the absorption of patients, the traditional Chinese medicine composition for treating thyroiditis is mainly prepared into powder for use clinically at present. Therefore, the invention further provides a preparation method of the Chinese patent medicine, which comprises the following steps:

step S10, cleaning and drying the raw materials in the Chinese patent medicine;

and step S20, crushing and sieving the dried raw materials, and then uniformly mixing to obtain the traditional Chinese medicine composition.

Wherein the raw materials comprise Haematitum, Pumex, lapis Chloriti, Scutellariae radix, radix et rhizoma Rhei, semen Sinapis Albae, cortex Cinnamomi, radix Paeoniae alba and lignum Aquilariae Resinatum. Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-30 parts of ruddle, 10-20 parts of pumice, 20-40 parts of lapis chlorite, 150-200 parts of scutellaria baicalensis, 150-200 parts of wine-treated rhubarb, 20-30 parts of white mustard seed, 10-20 parts of cinnamon, 30-50 parts of white paeony root and 10-20 parts of agilawood.

The preparation method comprises the steps of weighing the raw material components in proportion, respectively cleaning and drying, crushing and sieving the dried raw materials to obtain powdery raw materials, and uniformly mixing the powdery raw materials to obtain the traditional Chinese medicine composition, wherein the dosage form of the traditional Chinese medicine composition is powder.

The drying temperature is 50-70 ℃ so that the water content of the dried raw material is 5-15%, and therefore the subsequent crushing step is facilitated, and the crushed powdery raw material is not easy to agglomerate and block sieve pores. Further, the sieving is to sieve through 100-300 meshes.

The use method of the traditional Chinese medicine composition comprises the following steps: the dosage is 5-6 g each time, the warm boiled water is directly taken together or dissolved in the warm boiled water for taking, 2 times a day, and the administration is carried out once in the morning and at night.

It can be understood that the traditional Chinese medicine composition in the dosage form of tablets, pills and capsules can be prepared on the basis of the powder by a conventional method, for example, the preparation method of the capsules comprises the following steps: filling the uniformly mixed powdery raw materials (namely powder) into capsules to obtain capsules; the preparation method of the pill comprises the following steps: adding binder into the above mixed powder materials (powder) and making into pill, wherein the binder can be Mel, rice paste, batter or syrup.

The technical solutions of the present invention are further described in detail with reference to the following specific examples, which should be understood as merely illustrative and not limitative.

Example 1

The traditional Chinese medicine composition for treating thyroiditis comprises the following components in parts by mass: 25 parts of ruddle, 15 parts of pumice, 30 parts of lapis chlorite, 170 parts of scutellaria baicalensis, 170 parts of wine-processed rhubarb, 25 parts of white mustard seed, 15 parts of cinnamon, 40 parts of white paeony root and 15 parts of agilawood

Example 2

The traditional Chinese medicine composition for treating thyroiditis comprises the following components in parts by mass: 20 parts of ruddle, 20 parts of pumice, 20 parts of lapis chlorite, 200 parts of scutellaria baicalensis, 170 parts of wine-treated rhubarb, 27 parts of semen brassicae, 10 parts of cinnamon, 30 parts of white paeony root and 20 parts of agilawood.

Example 3

The traditional Chinese medicine composition for treating thyroiditis comprises the following components in parts by mass: 30 parts of ruddle, 10 parts of pumice, 40 parts of lapis chlorite, 150 parts of scutellaria baicalensis, 150 parts of wine rhubarb, 30 parts of semen brassicae, 20 parts of cinnamon, 50 parts of white paeony root and 10 parts of agilawood.

Example 4

The traditional Chinese medicine composition for treating thyroiditis comprises the following components in parts by mass: 30 parts of ruddle, 17 parts of bryozoatum, 20 parts of lapis chlorite, 180 parts of scutellaria baicalensis, 200 parts of wine-treated rhubarb, 20 parts of semen brassicae, 18 parts of cinnamon, 35 parts of white paeony root and 16 parts of agilawood.

Example 5

(1) The formula of the traditional Chinese medicine composition is the same as that of the embodiment 1;

(2) cleaning the raw material components of the traditional Chinese medicine composition, drying at 50 ℃ until the water content of the raw material is 12%, crushing the dried raw material, sieving with a 100-mesh sieve, and uniformly mixing the obtained powdery raw material to obtain the traditional Chinese medicine composition.

Example 6

(1) The formula of the traditional Chinese medicine composition is the same as that of the embodiment 2;

(2) cleaning the raw material components of the traditional Chinese medicine composition, drying at 60 ℃ until the water content of the raw material is 5%, crushing the dried raw material, sieving by a 300-mesh sieve, and uniformly mixing the obtained powdery raw material to obtain the traditional Chinese medicine composition.

Example 7

(1) The formula of the traditional Chinese medicine composition is the same as that of the embodiment 3;

(2) cleaning the raw material components of the traditional Chinese medicine composition, drying at 70 ℃ until the water content of the raw material is 10%, crushing the dried raw material, sieving by a 200-mesh sieve, and uniformly mixing the obtained powdery raw material to obtain the traditional Chinese medicine composition.

Example 8

(1) The formula of the traditional Chinese medicine composition is the same as that of the embodiment 4;

(2) cleaning the raw material components of the traditional Chinese medicine composition, drying at 60 ℃ until the water content of the raw material is 15%, crushing the dried raw material, sieving by a 140-mesh sieve, and uniformly mixing the obtained powdery raw material to obtain the traditional Chinese medicine composition.

The powder of the Chinese medicinal composition prepared in example 5 was used for treating patients with hashimoto's thyroiditis, and clinical treatment data shown in table 1 were obtained:

clinical data: 2010-2021, 1853 outpatients, all of whom were diagnosed with Hashimoto's thyroiditis, among which 1482 women, 371 men, ages 16-63, and the mean age 35.

The treatment method comprises the following steps: the traditional Chinese medicine composition prepared in the embodiment 5 is orally taken by a patient, 5-6 g of the composition is taken each time, 2 times are taken each day, the composition is taken once after breakfast and supper, 3 weeks are taken as a treatment course, and the treatment effect is counted after 5 treatment courses.

The evaluation standard of the curative effect is as follows: and (3) curing: the goiter disappears effectively: goiter and goiter become smaller

And (4) invalidation: without change or enlargement

Table 1 clinical treatment data

Therapeutic effects	Number of cases	Percentage of
			Cure of disease	463 example	25％
Is effective	1204 example	65％
			Invalidation	186 cases	10％

As can be seen from the table 1, the clinical effective rate of the traditional Chinese medicine composition for treating hashimoto's thyroiditis reaches up to 90%, and the traditional Chinese medicine composition has an excellent treatment effect on hashimoto's thyroiditis. Namely, the traditional Chinese medicine composition has good clinical curative effect on hashimoto's thyroiditis by designing the raw material components of the traditional Chinese medicine composition and the proportion of the components.

It should be noted that the principle of the Chinese medicinal compositions prepared in examples 6-8 is the same as that of example 5, and therefore, the Chinese medicinal compositions prepared by the methods have almost the same therapeutic effect on Hashimoto's thyroiditis.

The above is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall be included in the scope of the present invention.