阅读说明：本技术 一种治疗白喉的中药擦剂及其制备工艺 (A Chinese medicinal liniment for treating diphtheria, and its preparation method ) 是由 孔建明 于 2021-08-09 设计创作，主要内容包括：本发明属于中药擦剂领域,具体公开了一种治疗白喉的中药擦剂,其特征在于,包括如下重量配比的各组分：五倍子25-32克,冰片38-45克,大枣28-33克,白矾17-21克,余量为芝麻油。本发明所提供的中药擦剂,利用五倍子、冰片、大枣、白矾和芝麻油的复配,经大量临床验证,能够快速止痛,抑制溃烂,促进生肌,加速创面愈合,有效治疗白喉病。(The invention belongs to the field of traditional Chinese medicine liniment, and particularly discloses traditional Chinese medicine liniment for treating diphtheria, which is characterized by comprising the following components in parts by weight: 25-32 g of nutgall, 38-45 g of borneol, 28-33 g of Chinese date, 17-21 g of alum and the balance of sesame oil. The Chinese medicinal liniment provided by the invention utilizes the compounding of the gallnut, the borneol, the Chinese date, the alum and the sesame oil, and a large number of clinical verifications prove that the Chinese medicinal liniment can quickly relieve pain, inhibit fester, promote tissue regeneration, accelerate wound healing and effectively treat the white throat disease.)

1. The traditional Chinese medicine liniment for treating diphtheria is characterized by comprising the following components in parts by weight: 25-32 g of nutgall, 38-45 g of borneol, 28-33 g of Chinese date, 17-21 g of alum and the balance of sesame oil.

2. The traditional Chinese medicine liniment for treating diphtheria according to claim 1, wherein the liniment comprises the following components: the traditional Chinese medicine liniment comprises the following components in parts by weight: 30 g of gallnut, 40 g of borneol, 30 g of Chinese date, 20 g of alum and the balance of sesame oil.

3. The traditional Chinese medicine liniment for treating diphtheria according to claim 1, wherein the liniment comprises the following components: the jujube is denucleated, and the sesame oil is pure sesame oil without additives.

4. The preparation process of the traditional Chinese medicine liniment for treating diphtheria according to any one of claims 1 to 2, is characterized in that: the method comprises the following specific steps:

s1, weighing gallnut, borneol and Chinese date according to the weight ratio, respectively grinding and crushing, sieving by a 160-mesh sieve, and uniformly mixing to obtain a mixed material for later use;

s2, weighing the alum according to the weight ratio, and grinding the alum into fine powder with off-white color;

s3, mixing the mixture obtained in the S1 and the alum powder obtained in the S2, and blending with sesame oil to obtain the finished product of the traditional Chinese medicine liniment.

5. The traditional Chinese medicine liniment for treating diphtheria and the preparation process thereof according to claim 3, wherein the liniment comprises the following components: the use method of the finished product of the traditional Chinese medicine liniment comprises the following steps: directly applied to affected part three times a day.

6. The traditional Chinese medicine liniment for treating diphtheria and the preparation process thereof according to claim 4, wherein the liniment comprises the following components: white sugar is avoided in the using process of the finished product of the traditional Chinese medicine liniment.

Technical Field

The invention relates to the field of traditional Chinese medicine liniment, in particular to traditional Chinese medicine liniment for treating diphtheria and a preparation process thereof.

Background

Diphtheria (diphtheria) is an acute respiratory infectious disease caused by diphtheria bacillus, and has prominent clinical features of fever, suffocation, hoarseness, barking cough, congestion and swelling of mucous membranes of pharynx, larynx and the like and grey white pseudomembrane. Severe patients have obvious systemic poisoning symptoms, and myocarditis and peripheral nerve paralysis can be caused simultaneously. Diphtheria can be divided into four types, and the incidence rates of diphtheria are from high to low, pharyngeal diphtheria, laryngeal diphtheria, nasal diphtheria and diphtheria in other parts. Adults and older children are more in the form of pharyngeal diphtheria, with other types of diphtheria more commonly found in young children.

Diphtheria belongs to the category of traditional Chinese medicine epidemic febrile disease, and the diseases include pharyngitis, laryngitis, laryngopharyngitis, termite sore, white stubborn throat, white laryngitis and the like in the traditional Chinese medicine literature. The disease is distributed worldwide, can be attacked in four seasons, and is more in autumn and winter. At present, no better traditional Chinese medicine preparation for treating diphtheria exists clinically.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine liniment for treating diphtheria and a preparation process thereof, and aims to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: the traditional Chinese medicine liniment for treating diphtheria is characterized by comprising the following components in parts by weight: 25-32 g of nutgall, 38-45 g of borneol, 28-33 g of Chinese date, 17-21 g of alum and the balance of sesame oil.

Preferably, the traditional Chinese medicine liniment comprises the following components in parts by weight: 30 g of gallnut, 40 g of borneol, 30 g of Chinese date, 20 g of alum and the balance of sesame oil.

Preferably, the Chinese dates are denucleated, and the sesame oil is pure sesame oil without additives.

The invention also provides a preparation process of the traditional Chinese medicine liniment for treating diphtheria, which comprises the following specific steps:

s1, weighing gallnut, borneol and Chinese date according to the weight ratio, respectively grinding and crushing, sieving by a 160-mesh sieve, and uniformly mixing to obtain a mixed material for later use;

s2, weighing the alum according to the weight ratio, and grinding the alum into fine powder with off-white color;

s3 mixing the mixture of S1 and Alumen powder of S2, and concocting with oleum Sesami to obtain the final product

Further, the use method of the finished product of the traditional Chinese medicine liniment comprises the following steps: directly applied to affected part three times a day.

Furthermore, white sugar is avoided in the using process of the finished product of the traditional Chinese medicine liniment.

Compared with the prior art, the invention has the beneficial effects that:

the Chinese medicinal liniment provided by the invention utilizes the compounding of the gallnut, the borneol, the Chinese date, the alum and the sesame oil, and a large number of clinical verifications prove that the Chinese medicinal liniment can quickly relieve pain, inhibit fester, promote tissue regeneration, accelerate wound healing and effectively treat the white throat disease.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a technical scheme that: the traditional Chinese medicine liniment for treating diphtheria is characterized by comprising the following components in parts by weight: 25-32 g of nutgall, 38-45 g of borneol, 28-33 g of Chinese date, 17-21 g of alum and the balance of sesame oil.

Preferably, the traditional Chinese medicine liniment comprises the following components in parts by weight: 30 g of gallnut, 40 g of borneol, 30 g of Chinese date, 20 g of alum and the balance of sesame oil.

Preferably, the Chinese dates are denucleated, and the sesame oil is pure sesame oil without additives.

Galla chinensis, a gall on the leaves of Rhus chinensis Populus chinensis or Rhus pungens of the family Anacardiaceae, is mainly formed by parasitizing the aphids of Galla chinensis. Sour, astringent and cold in nature; entering lung, large intestine and kidney meridians; has the effects of astringing lung and reducing fire, astringing intestine and checking diarrhea, arresting sweating, stopping bleeding, astringing dampness and healing sore. It is commonly indicated for chronic cough due to lung deficiency, chronic diarrhea and dysentery due to lung heat with phlegm, spontaneous perspiration and night sweat, diabetes, hemafecia and hemorrhoidal bleeding, traumatic hemorrhage, carbuncle, swelling, sore and toxicity, and skin ulceration.

Borneolum, named as Borneolum, pericarpium Citri Tangerinae, folium Artemisiae Argyi, Borneolum Syntheticum, Serissa, Borneolum Syntheticum, etc., is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization; can be used for treating block pattern of coma, conjunctival congestion with swelling and pain, sore throat, aphtha, sore and ulcer with swelling and pain, and unhealed ulcer.

The pharmacokinetics of borneol are: the borneol is easy to be absorbed by mucous membrane and subcutaneous tissue, and is combined with glucuronic acid in vivo and then discharged out of the body; the 3H-borneol 1 mu Ci/(g body weight) can be quickly absorbed by intestinal mucosa after being irrigated to the stomach of a mouse, can permeate blood brain barrier after being administrated for 5 minutes, has higher concentration and longer retention time in central nerve, and the resuscitation effect of the medicine can be related to the central nerve; borneol can maintain higher blood concentration for a longer time in blood, is quickly eliminated by liver and kidney, and is not easy to accumulate; the half-life period of 3H-borneol 2.6 mu Ci/mouse intravenous injection is 2.8min, and the distribution is mainly heart, lung, liver, kidney and the like; each stomach is perfused by 3.5 mu Ci, the half-absorption period is 0.157 hour, the absorption coefficient is 0.25, and the bioavailability is poor; the elimination half-life is 5.3 hours, and accumulation is not easy.

The Chinese dates and the dried mature fruits of the Chinese dates have the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves. Tonify spleen and qi, nourish heart and induce tranquilization. It is commonly used for diarrhea due to spleen deficiency, asthenia, loose stool, hysteria, palpitation, insomnia, night sweat, thrombocytopenic purpura. As recorded in the book 'Benjing' of Chinese herbal medicine, the red dates have sweet and warm taste and warm property, enter spleen and stomach meridians, and have the functions of tonifying middle-jiao and Qi, nourishing blood and tranquilization and relieving drug properties; modern pharmacology finds that the red dates contain rich nutritional ingredients such as proteins, saccharides, organic acids, vitamin A, vitamin C, various trace calcium, amino acids and the like.

Alumen is prepared from sulfate mineral alunite by processing and refining. The external use has the efficacies of detoxifying, killing parasites, eliminating dampness and relieving itching; the oral administration has the efficacies of stopping bleeding, stopping diarrhea and dispelling wind-phlegm. The external treatment is used for eczema, mange tinea, rectocele, hemorrhoids and purulent otitis media; it is orally administered for treating chronic diarrhea, hematochezia, metrorrhagia, epilepsy, and mania.

The invention also provides a preparation process of the traditional Chinese medicine liniment for treating diphtheria, which comprises the following specific steps:

s1, weighing gallnut, borneol and Chinese date according to the weight ratio, respectively grinding and crushing, sieving by a 160-mesh sieve, and uniformly mixing to obtain a mixed material for later use;

s2, weighing the alum according to the weight ratio, and grinding the alum into fine powder with off-white color;

s3 mixing the mixture of S1 and Alumen powder of S2, and concocting with oleum Sesami to obtain the final product

Further, the use method of the finished product of the traditional Chinese medicine liniment comprises the following steps: directly applied to affected part three times a day for 3-5 days to cure.

Furthermore, white sugar is avoided in the using process of the finished product of the traditional Chinese medicine liniment.

The specific clinical cases are as follows:

example 1: patient 1, wangzhi, male, age 74, guan county, had severe ulcer of tongue at the time of treatment;

diphtheria symptoms were: the tongue causes infection, then develops into the throat, becomes red and white, belongs to acute infection, has high development speed, has the body temperature of over 39 ℃ frequently (the body temperature of a very serious patient can reach 40 ℃), is not taken with semen, is listened, can not eat and drink after being infected for 12 hours, can not produce sound, can directly infect little tongue and is white ulcer nearby;

the treatment process comprises the following steps: after the test in Beijing 301 hospital, the disease is diagnosed as asymptomatic bacterial infection and cured 4 months after the medicine is taken.

Example 2: patient 2, a certain Wang, male, born for 3 months, Puyang Henan, showed clinically the oral ulcer, fever 39 degrees, body temperature returned to normal after 3 days of medication, and the oral wound surface was improved.

Example 3: patient 3, a certain person in Lu, a woman, a famous county in Hebei, have clinical manifestations of no eating, no drinking and difficult speaking due to pharyngeal diphtheria in oral cavity, no effective treatment in Zhengzhou affiliated hospital for one month in 2014, and no symptom bacterial infection is detected in Beijing cooperation hospital; after the treatment of the traditional Chinese medicine, diphtheria, tongue ulcer, white tongue and throat, incapability of drinking and eating, incapability of speaking, serious oral odor and putrefactive halitosis odor are preliminarily diagnosed, symptoms are relieved on the day of medicine application, porridge can be eaten after four days, normal diet can be realized after one week, and five months can be recovered as before.

Example 4: clinically, the diphtheria of women has more diseases, initial symptoms are that the pharynx and the throat are itchy and uncomfortable, the tongue turns red and turns white again, adults cannot eat and can not speak, the effect is achieved within five minutes after the diphtheria is generally taken, the diphtheria can drink water in the second day, the diphtheria can eat and eat porridge in three days, the diphtheria can eat and eat food normally in seven days, the diphtheria can make hoarse voice in 15 days, and the diphtheria can make voice normally in 30 days.

Example 5: the clinical treatment patients are newborn babies 22 days after birth, can not eat milk, cry once, have high fever symptoms, can not feed milk within one hour after being coated with the medicine, can feed milk after one hour, can be coated three times a day, can recover after several days, and are forbidden to use white sugar water during the treatment period.

Example 6: clinically, the number of children aged 0 to 6 years is large, especially the number of children under 1 year is large, and the clinical manifestations are as follows: when the child is initially fed with saliva and cries after eating milk, the child begins to take the medicine within 0-12 months, the first defecation is black, the second defecation is recovered to be normal, the body temperature is up to 38-40 ℃, the anti-inflammatory medicine is ineffective, and the fever is relieved after the child is cured.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.