阅读说明：本技术 一种治疗水痘、黄水疮、带状疱疹的药膏及制备方法 (Ointment for treating varicella, yellow water sore and herpes zoster and preparation method thereof ) 是由 贺绍峰 于 2021-08-10 设计创作，主要内容包括：本申请提供了一种治疗水痘、黄水疮、带状疱疹的药膏及制备方法,包含盐酸二氧丙嗪粉0.3～1.0份,马来酸氯苯那敏0.2～0.8份,醋酸泼尼松粉0.25～1.0份,氯胺苯醇粉0.5～1.9份,黄芩浸膏粉6～12份,川黄柏粉6～12份,盐酸小檗碱粉8～19份,盐酸环丙沙星乳膏11～28份,轻粉0.2～1.9份。将药片研磨筛分后与黄芩浸膏粉、川黄柏粉、轻粉加入盐酸环丙沙星乳膏中,搅拌均匀,得到成品。本申请创造性地将中药与西药两者配合使用,能够较好地抑制水泡破溃面的坏疽和瘙痒程度,为患者解除病痛。本申请所采用的药材药源易得,成本低廉,减轻患者负担,无毒副作用。(The application provides an ointment for treating chicken pox, impetigo and herpes zoster and a preparation method thereof, and the ointment comprises 0.3-1.0 part of dioxopromethazine hydrochloride powder, 0.2-0.8 part of chlorphenamine maleate, 0.25-1.0 part of prednisone acetate powder, 0.5-1.9 parts of chlorphenamine, 6-12 parts of scutellaria extract powder, 6-12 parts of phellodendron amurense powder, 8-19 parts of berberine hydrochloride powder, 11-28 parts of ciprofloxacin hydrochloride cream and 0.2-1.9 parts of calomel. Grinding and sieving the tablets, adding the tablets, scutellaria baicalensis extract powder, phellodendron amurense powder and calomel into the ciprofloxacin hydrochloride cream, and uniformly stirring to obtain a finished product. The application creatively combines the traditional Chinese medicine and the western medicine for use, can better inhibit gangrene and pruritus of the blister burst surface and relieve pain of patients. The medicine sources of the medicinal materials adopted by the application are easy to obtain, the cost is low, the burden of a patient is relieved, and no toxic or side effect exists.)

1. An ointment for treating varicella, yellow water sore and herpes zoster is characterized in that: comprises the following raw medicines in parts by weight: 0.3-1.0 part of dioxopromethazine hydrochloride powder, 0.2-0.8 part of chlorpheniramine maleate, 0.25-1.0 part of prednisone acetate powder, 0.5-1.9 parts of chlorpheniramine maleate powder, 6-12 parts of scutellaria baicalensis extract powder, 6-12 parts of phellodendron amurense powder, 8-19 parts of berberine hydrochloride powder, 11-28 parts of ciprofloxacin hydrochloride emulsifiable paste and 0.2-1.9 parts of calomel.

2. The ointment of claim 1 for treating varicella, impetigo, and shingles, comprising: comprises the following raw medicines in parts by weight: 0.6 part of dioxopromethazine hydrochloride powder, 0.5 part of chlorpheniramine maleate, 0.7 part of prednisone acetate powder, 1.1 parts of chlorpheniramine powder, 8 parts of scutellaria baicalensis extract powder, 7 parts of phellodendron amurense powder, 13 parts of berberine hydrochloride powder, 20 parts of ciprofloxacin hydrochloride cream and 1.0 part of calomel.

3. The ointment of claim 1 for treating varicella, impetigo, and shingles, comprising: comprises the following raw medicines in parts by weight: 0.7 part of dioxopromethazine hydrochloride powder, 0.5 part of chlorpheniramine maleate, 0.6 part of prednisone acetate powder, 1.3 parts of chlorpheniramine powder, 8 parts of scutellaria baicalensis extract powder, 9 parts of phellodendron amurense powder, 11 parts of berberine hydrochloride powder, 22 parts of ciprofloxacin hydrochloride cream and 0.8 part of calomel.

4. The ointment of claim 1 for treating varicella, impetigo, and shingles, comprising: the dioxypromethazine hydrochloride powder adopts a commercially available dioxypromethazine hydrochloride tablet; the chlorpheniramine maleate adopts a commercially available chlorpheniramine maleate sheet; the prednisone acetate powder adopts a commercially available product prednisone acetate tablet; the chloraminophen alcohol powder adopts a commercially available product chloraminophen alcohol sheet; the berberine hydrochloride powder adopts a commercially available product berberine hydrochloride tablet.

5. The method for preparing the ointment for treating chicken pox, yellow water sore and herpes zoster according to claim 1, which comprises the following steps: the method comprises the following steps:

(1) weighing corresponding parts of dioxopromethazine hydrochloride tablets, chlorphenamine maleate tablets, prednisone acetate tablets, chlorphenamine maleate tablets, scutellaria baicalensis extract powder, phellodendron amurense powder, berberine hydrochloride tablets, ciprofloxacin hydrochloride cream and calomel;

(2) grinding dioxopromethazine hydrochloride tablet, chlorphenamine maleate tablet, prednisone acetate tablet, chlorphenamine maleate tablet, and berberine hydrochloride tablet in a micronizer for 20min, and sieving with 150 mesh sieve to obtain crude drug powder;

(3) adding the ground and screened original medicine powder, the scutellaria baicalensis extract powder, the phellodendron amurense powder and the calomel into the ciprofloxacin hydrochloride cream, and uniformly stirring to obtain a finished product.

Technical Field

The application relates to the technical field of medicines, in particular to an ointment for treating varicella, yellow water sore and herpes zoster and a preparation method thereof.

Background

The skin disease is a pathological process which is caused by the change of the form, structure and function of the skin after the skin is affected by internal and external factors, and various clinical successive manifestations are correspondingly generated. The incidence of skin diseases is high, many are light, and do not affect health, but few are heavy and even can endanger life. With the gradual deterioration of human living environment, air and water pollution is serious, and diseases of skin as human barrier are also serious. Meanwhile, the human stress is increased, the resistance is weakened, and the barrier effect of the skin is greatly influenced. Among the skin diseases, chicken pox, yellow water sore, herpes zoster, etc. are especially common and serious. The modern medicine mainly takes ganciclovir, mecobalamin and vitamins as main medicines for treating varicella and herpes zoster, has a certain curative effect, but sequela neuralgia is often left; and the scar can be left by careless treatment of the impetigo.

Therefore, the technical personnel in the field provide an ointment for treating varicella, yellow water sore and herpes zoster and a preparation method thereof, so as to solve the problems in the background technology.

Disclosure of Invention

Aiming at the defects of the prior art, the application aims to provide the ointment for treating the chicken pox, the impetigo and the herpes zoster and the preparation method thereof.

The technical scheme adopted by the application is as follows:

an ointment for treating chicken pox, impetigo and herpes zoster comprises the following raw medicines in parts by weight: 0.3-1.0 part of dioxopromethazine hydrochloride powder, 0.2-0.8 part of chlorpheniramine maleate, 0.25-1.0 part of prednisone acetate powder, 0.5-1.9 parts of chlorpheniramine maleate powder, 6-12 parts of scutellaria baicalensis extract powder, 6-12 parts of phellodendron amurense powder, 8-19 parts of berberine hydrochloride powder, 11-28 parts of ciprofloxacin hydrochloride emulsifiable paste and 0.2-1.9 parts of calomel.

Further, the ointment for treating the chicken pox, the yellow water sore and the herpes zoster comprises the following raw medicines in parts by weight: 0.6 part of dioxopromethazine hydrochloride powder, 0.5 part of chlorpheniramine maleate, 0.7 part of prednisone acetate powder, 1.1 parts of chlorpheniramine powder, 8 parts of scutellaria baicalensis extract powder, 7 parts of phellodendron amurense powder, 13 parts of berberine hydrochloride powder, 20 parts of ciprofloxacin hydrochloride cream and 1.0 part of calomel.

Further, the ointment for treating the chicken pox, the yellow water sore and the herpes zoster comprises the following raw medicines in parts by weight: 0.7 part of dioxopromethazine hydrochloride powder, 0.5 part of chlorpheniramine maleate, 0.6 part of prednisone acetate powder, 1.3 parts of chlorpheniramine powder, 8 parts of scutellaria baicalensis extract powder, 9 parts of phellodendron amurense powder, 11 parts of berberine hydrochloride powder, 22 parts of ciprofloxacin hydrochloride cream and 0.8 part of calomel.

Further, the ointment for treating the chicken pox, the yellow water sore and the herpes zoster adopts the dioxopromethazine hydrochloride tablet which is a commercial product; the chlorpheniramine maleate adopts a commercially available chlorpheniramine maleate sheet; the prednisone acetate powder adopts a commercially available product prednisone acetate tablet; the chloraminophen alcohol powder adopts a commercially available product chloraminophen alcohol sheet; the berberine hydrochloride powder adopts a commercially available product berberine hydrochloride tablet.

Further, the preparation method of the ointment for treating chicken pox, yellow water sore and herpes zoster comprises the following steps:

(1) weighing corresponding parts of dioxopromethazine hydrochloride tablets, chlorphenamine maleate tablets, prednisone acetate tablets, chlorphenamine maleate tablets, scutellaria baicalensis extract powder, phellodendron amurense powder, berberine hydrochloride tablets, ciprofloxacin hydrochloride cream and calomel;

(2) grinding dioxopromethazine hydrochloride tablet, chlorphenamine maleate tablet, prednisone acetate tablet, chlorphenamine maleate tablet, and berberine hydrochloride tablet in a micronizer for 20min, and sieving with 150 mesh sieve to obtain crude drug powder;

(3) adding the ground and screened original medicine powder, the scutellaria baicalensis extract powder, the phellodendron amurense powder and the calomel into the ciprofloxacin hydrochloride cream, and uniformly stirring to obtain a finished product.

The beneficial effect of this application lies in:

(1) the application provides an ointment for treating chicken pox, yellow water sore and herpes zoster, which is suitable for the initial control of sores such as chicken pox, herpes simplex, herpes zoster and yellow water sore, is also suitable for the treatment of erosion by breaking water vacuole in the middle period, and has the effects of removing necrosis, promoting granulation, scabbing and repairing skin. The medicine raw materials of the application comprise traditional Chinese medicine and western medicine components, and the adopted western medicines are all common marketed medicines, so that the cost is low; the adopted traditional Chinese medicinal materials are easily available in medicinal sources, low in cost, capable of relieving the burden of patients and free of toxic and side effects.

(2) The application creatively combines the traditional Chinese medicine and the western medicine for use, can better inhibit gangrene and pruritus degree of the blister burst surface, relieves pains for patients, and adopts a proper preparation process, greatly improves the treatment effect, breaks through the conventional concept, and obtains unexpected curative effect.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Example 1

An ointment for treating chicken pox, impetigo and herpes zoster comprises the following raw medicines in parts by weight: 0.6 part of dioxopromethazine hydrochloride powder, 0.5 part of chlorpheniramine maleate, 0.7 part of prednisone acetate powder, 1.1 parts of chlorpheniramine powder, 8 parts of scutellaria baicalensis extract powder, 7 parts of phellodendron amurense powder, 13 parts of berberine hydrochloride powder, 20 parts of ciprofloxacin hydrochloride cream and 1.0 part of calomel. The preparation method comprises the following steps:

(1) weighing corresponding parts of dioxopromethazine hydrochloride tablets, chlorphenamine maleate tablets, prednisone acetate tablets, chlorphenamine maleate tablets, scutellaria baicalensis extract powder, phellodendron amurense powder, berberine hydrochloride tablets, ciprofloxacin hydrochloride cream and calomel;

(2) grinding dioxopromethazine hydrochloride tablet, chlorphenamine maleate tablet, prednisone acetate tablet, chlorphenamine maleate tablet, and berberine hydrochloride tablet in a micronizer for 20min, and sieving with 150 mesh sieve to obtain crude drug powder;

(3) adding the ground and screened original medicine powder, the scutellaria baicalensis extract powder, the phellodendron amurense powder and the calomel into the ciprofloxacin hydrochloride cream, and uniformly stirring to obtain a finished product.

Example 2

An ointment for treating chicken pox, impetigo and herpes zoster comprises the following raw medicines in parts by weight: 0.7 part of dioxopromethazine hydrochloride powder, 0.5 part of chlorpheniramine maleate, 0.6 part of prednisone acetate powder, 1.3 parts of chlorpheniramine powder, 8 parts of scutellaria baicalensis extract powder, 9 parts of phellodendron amurense powder, 11 parts of berberine hydrochloride powder, 22 parts of ciprofloxacin hydrochloride cream and 0.8 part of calomel. The preparation method comprises the following steps:

(1) weighing corresponding parts of dioxopromethazine hydrochloride tablets, chlorphenamine maleate tablets, prednisone acetate tablets, chlorphenamine maleate tablets, scutellaria baicalensis extract powder, phellodendron amurense powder, berberine hydrochloride tablets, ciprofloxacin hydrochloride cream and calomel;

(2) grinding dioxopromethazine hydrochloride tablet, chlorphenamine maleate tablet, prednisone acetate tablet, chlorphenamine maleate tablet, and berberine hydrochloride tablet in a micronizer for 20min, and sieving with 150 mesh sieve to obtain crude drug powder;

(3) adding the ground and screened original medicine powder, the scutellaria baicalensis extract powder, the phellodendron amurense powder and the calomel into the ciprofloxacin hydrochloride cream, and uniformly stirring to obtain a finished product.

Test of drug efficacy

1. The drugs prepared in examples 1 and 2 were selected for clinical trials.

The control group was strictly established according to the design scheme of parallel, random, control experiment, and the clinical efficacy of the drugs prepared in examples 1 and 2 was observed.

2. Selection of pathologies

Varicella is clinically characterized in that various rashes such as macula, pimple, herpes, incrustation and the like appear in succession on the skin mucosa and exist simultaneously; impetigo is mainly manifested by symptoms of small papules, blisters, pustules, crusts and the like; herpes zoster is characterized clinically by fever, weakness, swelling and pain of local lymph nodes, and burning skin of affected parts.

And (3) testing pathological standards:

inclusion cases: patients with diagnosis conforming to the diagnosis standard of varicella, impetigo and herpes zoster can be brought into the test case with the informed consent of the patients or family members between the ages of 2 and 75.

Excluding cases: (1) patients in acute exacerbation; (2) people with age below 2 years and over 75 years, pregnant women or lactating women, who are allergic to the medicine; (3) if the patient does not meet the inclusion criteria, is not taking the medicine according to the regulations, cannot judge the curative effect or the data is not complete, the judgment of the curative effect is affected.

3. Test method

The grouping method comprises the following steps: random and control experiments are adopted for observation, a random control grouping method is adopted for the cases brought into the test, a treatment group and a control group are found out on a random table, and the two groups of cases are ensured to be close to each other in the aspects of sex, age, course of disease and the like. The number of total cases is 430, 118 varicella, 176 yellow water sores and 136 herpes zoster, and each disease is divided into three groups.

4. Method of treatment

(1) Control group: the patient applies the acyclovir emulsifiable paste for 4-6 times every day, the interval between each application and the previous application is at least 2 hours, and the application time is one week.

(2) Treatment groups: the medicine prepared in the embodiment 1 or the embodiment 2 is applied for 4-6 times every day, each time of application is at least 2 hours away from the previous time, and the application time is one week.

5. Criteria for efficacy assessment

(1) The standard of cure is as follows: the chickenpox and the abscess disappear, and the symptoms such as pruritus, gall, fever and the like do not exist;

(2) satisfaction criteria: the skin does not have sequela such as keloid, pruritus and the like, and sequela such as neuralgia and the like; the patient is scored according to the satisfaction degree, the range is 0-10 points, and the average score is calculated.

6. The results of the treatment are shown in Table 1

TABLE 1 therapeutic results Table

The above table shows that the medicine has definite curative effect, and the total effective rate is more than 91%. Clinical observation shows that: the medicine has obvious curative effect on treating the chicken pox, the impetigo and the herpes zoster, is superior to a control group, has higher satisfaction degree for no sequela, and fully embodies the unexpected curative effect obtained by matching the traditional Chinese medicine with the western medicine.

The above description is only for the purpose of illustrating the preferred embodiments of the present application and is not to be construed as limiting the present application, and all equivalent variations and modifications within the scope of the present application are intended to be covered by the present application. Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.