阅读说明：本技术 苯并硫杂二氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 (Benzothiadiazepine compounds and their use as bile acid modulators ) 是由 P-G.吉尔伯格 J.马特森 I.斯塔克 S.S.库尔卡尼 于 2020-02-06 设计创作，主要内容包括：本发明涉及式(I)的1,2,5-苯并硫杂二氮杂环庚三烯衍生物。这些化合物为具有顶端钠依赖性胆汁酸转运蛋白(ASBT)和/或肝脏胆汁酸运输(LBAT)抑制活性的胆汁酸调节剂。本发明亦关于包含这些化合物的药物组合物,及这些化合物在治疗心血管疾病、脂肪酸代谢及葡萄糖利用病症、胃肠道疾病及肝病中的用途。(The invention relates to 1,2, 5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators with apical sodium-dependent bile acid transporter (ASBT) and/or hepatic bile acid transport (LBAT) inhibitory activity. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.)