阅读说明：本技术 一种自膨胀超吸水锁水微负压敷料及制备方法 (Self-expansion super-water-absorption water-locking micro-negative pressure dressing and preparation method thereof ) 是由 罗滔 于 2021-08-26 设计创作，主要内容包括：本发明提供了一种自膨胀超吸水锁水微负压敷料及制备方法,所述自膨胀超吸水锁水微负压敷料包括：自膨胀高吸水多孔材料,用于吸液自膨胀和止血；锁水纤维,用于吸液并保证液体不会渗出；气密性防水粘性生物膜,用于造成密封环境,并在自膨胀高吸水多孔材料膨胀后产生负压；所述气密性防水粘性生物膜包覆在自膨胀高吸水多孔材料和锁水纤维外,所述自膨胀高吸水多孔材料和锁水纤维通过偶联反应偶联为一体材,本发明能够在吸液过程中于内部产生稳定的微负压,不依赖于外部负压设备,能够自动持续吸收伤口内部难以流出的渗液,加速创面愈合。(The invention provides a self-expanding super water-absorbing and water-locking micro negative pressure dressing and a preparation method thereof, wherein the self-expanding super water-absorbing and water-locking micro negative pressure dressing comprises the following components: the self-expansion high water absorption porous material is used for absorbing liquid, self-expanding and stopping bleeding; the water locking fiber is used for absorbing liquid and ensuring that the liquid cannot seep out; the airtight waterproof viscous biological membrane is used for creating a sealed environment and generating negative pressure after the self-expansion high-water-absorption porous material expands; the air-tight waterproof viscous biomembrane is coated outside the self-expansion high water absorption porous material and the water locking fiber, and the self-expansion high water absorption porous material and the water locking fiber are coupled into a whole through coupling reaction.)

1. The self-expanding super-water-absorbing and water-locking micro negative pressure dressing is characterized by comprising the following components in parts by weight:

the self-expansion high water absorption porous material is used for absorbing liquid, self-expanding and stopping bleeding;

the water locking fiber is used for absorbing liquid and ensuring that the liquid cannot seep out;

the airtight waterproof viscous biological membrane is used for creating a sealed environment and generating negative pressure after the self-expansion high-water-absorption porous material expands;

the air-tight waterproof viscous biomembrane is coated outside the self-expansion high water absorption porous material and the water locking fiber, and the self-expansion high water absorption porous material and the water locking fiber are coupled into a whole material through a coupling reaction.

2. The self-expanding superabsorbent water-locking micro-negative pressure dressing of claim 1, further comprising an antimicrobial agent for combating bacteria and viruses, the antimicrobial agent being composited within the self-expanding superabsorbent porous material.

3. The self-expanding superabsorbent water-locking micro-negative pressure dressing of claim 1, wherein the self-expanding superabsorbent porous material is a material obtained by a cross-linking reaction and a pore-forming reaction of a polyhydroxy polymer and a polysaccharide, the polysaccharide comprising chitosan, alginate, dextran and plant polysaccharide.

4. The self-expanding superabsorbent water-locking micro-negative pressure dressing of claim 1, wherein the water-locking fiber is one or more of modified polyacrylamide, sodium polyacrylate, and polyacrylic resin fiber.

5. The self-expanding super water-absorbing and water-locking micro negative pressure dressing as claimed in claim 1, wherein the antibacterial agent or antibacterial sol is one or more of inorganic salt antibacterial agent, organic antibacterial agent and silver sulfadiazine.

6. The self-expanding superabsorbent water-lock micro-negative pressure dressing of claim 1, wherein the air-tight waterproof adhesive biofilm is a modified cellulose gel film, an alginate gel, or a chitosan gel.

7. The self-expanding super water-absorbing and water-locking micro negative pressure dressing as claimed in claim 3, wherein the polyhydroxy polymer is obtained by polymerizing a monomer having both carbon-carbon double bond and alcoholic hydroxyl group by copolymerization or homopolymerization method.

8. The self-expanding super water-absorbing and water-locking micro negative pressure dressing as claimed in claim 1, wherein the dressing has a thickness of 1mm to 5mm, a liquid absorption rate of 1000% to 2000%, a liquid absorption self-expansion rate of 1000% to 3000%, a volume water-locking rate of 50% to 90%, and a generated negative pressure of-10 Pa to-1000 Pa.

9. The self-expanding superabsorbent water-locking micro-negative pressure dressing according to claim 1, wherein the self-expanding superabsorbent water-locking micro-negative pressure dressing is applied to wounds and wounds requiring drainage, in particular burn wounds, ulcer wounds, diabetic wounds, chronic intractable wounds, surgical wounds and infected exudate wounds.

10. A method for preparing a self-swelling superabsorbent water-locking micro negative pressure dressing, which is used for preparing the self-swelling superabsorbent water-locking micro negative pressure dressing as claimed in one of the claims 1 to 9, and is characterized in that the preparation method comprises the following steps:

step one, preparing a self-expanding high water absorption porous material;

weighing a polyhydroxy polymer, mixing the polyhydroxy polymer with distilled water, uniformly stirring and dissolving, fully foaming the solution by adopting a supercritical gas foaming process, adding a certain mass of a cross-linking agent into the foamed solution, uniformly stirring, and then placing into a mold for molding to obtain the self-expanding high-water-absorption porous material;

secondly, compounding the water-locking fiber with a self-expanding high water-absorbing porous material;

coupling the fiber with water locking performance to the self-expanding high water absorption porous material through a coupling reaction to obtain the self-expanding high water absorption water locking porous material;

step three, forming the self-expanding super water-absorbing and water-locking micro-negative pressure dressing;

compounding an airtight waterproof viscous biomembrane with good biocompatibility with a self-expanding high water-absorbing and water-locking porous material to obtain a self-expanding super water-absorbing and water-locking micro negative pressure dressing;

step four, compounding the antibacterial agent;

sterilizing the deeply cleaned sample, and compounding the sample with an antibacterial agent;

fifthly, post-processing of the self-expanding super-absorbent water-locking micro negative pressure dressing;

the self-expanding super-absorbent water-locking micro negative pressure dressing is cut into proper size and shape according to different positions of the wound or the wound on the human body, the size of the liquid seepage amount, the size of the wound and different types of the wound.

[ technical field ] A method for producing a semiconductor device

The invention relates to the technical field of medical materials, in particular to a self-expanding super-absorbent water-locking micro negative pressure dressing and a preparation method thereof.

[ background of the invention ]

Negative pressure drainage wound therapy (NPWT) is a new method for accelerating wound healing in recent years, and has been widely applied to the treatment of a series of wounds which are difficult to heal, including acute, chronic and infectious wounds. The technique not only enhances the drainage effect of the wound surface, but also can obviously accelerate the closure of the infected lacuna, promote the wound healing, greatly reduce the use of antibiotics, effectively prevent the occurrence of infection, shorten the hospitalization time of the patient, relieve the pain of the patient and reduce the workload of medical care personnel.

The negative pressure dressing is a series of dressings developed according to the negative pressure drainage technology and used for wound nursing. The negative pressure dressing keeps the wound in a negative pressure state, can improve the healing rate of the wound surface, promote the growth of cell tissues, reduce the field planting and the propagation of bacteria, can reduce the times of replacing the dressing to the minimum, and achieves the aim of quickly healing the wound. The medicine has good treatment effect on patients who suffer from hemiplegia, paraplegia, paralysis and long-term bed rest and suffer from slow blood flow, no contraction force of muscles and easy wound ulceration.

However, the conventionally adopted negative pressure dressing has many disadvantages in clinical application, for example, the drainage effect is poor, and the maintenance time is short; the blockage of the drainage tube is easily caused; the antibacterial property is not available, and the wound infection is easy to cause; the dressing itself needs to be connected with a drainage tube, which brings troubles for replacement. Therefore, the development of wound care for patients suffering from wound ulceration due to long-term bed rest or patients suffering from scalds and burns is urgently needed in clinic.

The micro-negative pressure technology is a brand-new clinical treatment method, and utilizes the super-water-absorption and water-locking and expansion characteristics of the dressing to form continuous micro-negative pressure, so that the wound surface or wound exudate can be quickly absorbed, and the wound surface drainage effect is achieved. In recent years, a new material created by improving the negative pressure drainage technology can promote the growth of a wound surface through slight negative pressure generated after a self expanding agent absorbs liquid. However, in clinical application, the exudation of the wound surface is often more in the early stage, and although the new material has a certain liquid absorption rate, the new material cannot provide continuous negative pressure due to no water locking property of the new material, the absorbed exudation is easy to exude for the second time, the price of the raw material of the material is more expensive than that of the common skin-grafting gauze, and the treatment cost is obviously increased due to frequent replacement in the early stage. Meanwhile, a large amount of necrotic tissues exist on the early wound surface, and the material does not have the anti-infection effect, cannot be used together with an antibacterial agent and has the risk of infection.

Therefore, there is a need to develop a self-expanding super absorbent water-locking micro negative pressure dressing and a preparation method thereof to overcome the shortcomings of the prior art, so as to solve or alleviate one or more of the above problems.

[ summary of the invention ]

In view of the above, the invention provides a self-expanding super-absorbent water-locking micro negative pressure dressing and a preparation method thereof, overcomes the defects of the existing negative pressure drainage dressing, overcomes the defects of the prior art, solves the problems that the traditional and existing dressings have low imbibition rate, no water-locking performance, frequent replacement, difficulty in removing deep seepage, lack of anti-infection and the like and cannot meet the actual requirements, develops a self-expanding micro negative pressure high water-locking dressing which has high imbibition, self-expansion, micro negative pressure, water locking, good wound surface adhesiveness, good biocompatibility and anti-infection.

In one aspect, the present invention provides a self-expanding superabsorbent water-locking micro-negative pressure dressing, comprising:

the self-expansion high water absorption porous material is used for absorbing liquid, self-expanding and stopping bleeding;

the water locking fiber is used for absorbing liquid and ensuring that the liquid cannot seep out;

the airtight waterproof viscous biological membrane is used for creating a sealed environment and generating negative pressure after the self-expansion high-water-absorption porous material expands;

the air-tight waterproof viscous biomembrane is coated outside the self-expansion high water absorption porous material and the water locking fiber, and the self-expansion high water absorption porous material and the water locking fiber are coupled into a whole material through a coupling reaction.

The above aspects and any possible implementations further provide an implementation in which the self-expanding super absorbent water-holding micro negative pressure dressing further comprises an antibacterial agent for resisting bacteria and viruses, and the antibacterial agent is compounded in the self-expanding super absorbent porous material.

The above aspects and any possible implementations further provide an implementation where the self-expanding superabsorbent porous material is a material obtained by reacting a polyhydroxy polymer and a polysaccharide with pore formation through a cross-linking reaction, the polysaccharide including but not limited to chitosan, alginate, dextran, and plant polysaccharide.

The above aspects and any possible implementations further provide an implementation, in which the water-retaining fiber is one or more of modified polyacrylamide, sodium polyacrylate, and polyacrylic resin fiber.

The above aspects and any possible implementations further provide an implementation where the antibacterial agent or antibacterial sol is one or more of an inorganic salt antibacterial agent, an organic antibacterial agent, and silver sulfadiazine.

The above aspects and any possible implementations further provide an implementation in which the air-tight, water-resistant, and adhesive-resistant biofilm is a modified cellulose gel film, an alginate gel, or a chitosan gel.

The above aspects and any possible implementations further provide an implementation, in which the polyhydroxy polymer is a polyhydroxy polymer obtained by polymerizing a monomer having both a carbon-carbon double bond and an alcoholic hydroxyl group by a copolymerization or homopolymerization method.

The above aspect and any possible implementation manner further provide an implementation manner, wherein the dressing has a thickness of 1mm to 5mm, a liquid absorption rate of 1000% to 2000%, a liquid absorption self-expansion rate of 1000% to 3000%, a volume water locking rate of 50% to 90%, and negative pressure of-10 Pa to-1000 Pa.

The above aspects and any possible implementation manners further provide an implementation manner, and the application fields of the self-expanding super water-absorbing and water-locking micro negative pressure dressing are wounds and wounds needing drainage, specifically include but are not limited to burn wounds, ulcer wounds, diabetic wounds, chronic intractable wounds, operation wounds and infected exudate wounds.

The above aspect and any possible implementation manner further provide a preparation method of the self-expanding super water-absorbing and water-locking micro negative pressure dressing, wherein the preparation method comprises the following steps:

step one, preparing a self-expanding high water absorption porous material;

weighing a polyhydroxy polymer, mixing the polyhydroxy polymer with distilled water, uniformly stirring and dissolving, fully foaming the solution by adopting a supercritical gas foaming process, adding a certain mass of a cross-linking agent into the foamed solution, uniformly stirring, and then placing into a mold for molding to obtain the self-expanding high-water-absorption porous material;

secondly, compounding the water-locking fiber with a self-expanding high water-absorbing porous material;

coupling the fiber with water locking performance to the self-expanding high water absorption porous material through a coupling reaction to obtain the self-expanding high water absorption water locking porous material;

step three, forming the self-expanding super water-absorbing and water-locking micro-negative pressure dressing;

compounding an airtight waterproof viscous biomembrane with good biocompatibility with a self-expanding high water-absorbing and water-locking porous material to obtain a self-expanding super water-absorbing and water-locking micro negative pressure dressing;

step four, compounding the antibacterial agent;

sterilizing the deeply cleaned sample, and compounding the sample with an antibacterial agent;

fifthly, post-processing of the self-expanding super-absorbent water-locking micro negative pressure dressing;

the self-expanding super-absorbent water-locking micro negative pressure dressing is cut into proper size and shape according to different positions of the wound or the wound on the human body, the size of the liquid seepage amount, the size of the wound and different types of the wound.

Compared with the prior art, the invention can obtain the following technical effects:

1. the micro-negative pressure drainage of the self-expanding super-absorbent water-locking micro-negative pressure dressing avoids the compression and stimulation effects of atmospheric pressure generated by higher negative pressure of a negative pressure closed drainage technology on local wound surfaces, is more beneficial to wound surface healing and shortens the healing time;

2. the self-expanding super-absorbent water-locking micro negative pressure dressing has a strong water-locking effect, can control the evaporation of water, has a water evaporation rate similar to that of normal skin, can keep a moist and sealed microenvironment of a wound surface, and provides a proper healing environment for re-epithelialization;

3. the self-expanding super-absorbent water-locking micro negative pressure dressing can be firmly contacted with the skin and is not easy to fall off; meanwhile, the contact surface of the wound dressing and the skin is a biological mucosa layer, so that the wound dressing can be easily separated from the wound surface, the pain is not obvious, and serious bleeding and secondary wound rupture cannot be caused.

Of course, it is not necessary for any one product in which the invention is practiced to achieve all of the above-described technical effects simultaneously.

[ description of the drawings ]

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic diagram of the self-expanding super absorbent water-locking micro-negative pressure dressing provided by one embodiment of the invention for generating micro-negative pressure absorption seepage;

fig. 2 is a schematic diagram of the performance of the self-expanding super water-absorbing and water-locking micro-negative pressure dressing provided by one embodiment of the invention.

[ detailed description ] embodiments

For better understanding of the technical solutions of the present invention, the following detailed descriptions of the embodiments of the present invention are provided with reference to the accompanying drawings.

It should be understood that the described embodiments are only some embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The terminology used in the embodiments of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the examples of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

The invention provides a self-expanding super water-absorbing and water-locking micro negative pressure dressing, which comprises a self-expanding high water-absorbing porous material, water-locking fibers, an airtight waterproof adhesive biological membrane and an antibacterial agent, wherein the self-expanding high water-absorbing porous material is used for absorbing liquid, self-expanding and stopping bleeding; the water locking fiber is used for absorbing liquid and ensuring that the liquid cannot seep out; the airtight waterproof viscous biological membrane is used for creating a sealed environment and generating negative pressure after the self-expansion high-water-absorption porous material expands; the air-tight waterproof viscous biomembrane is coated outside the self-expansion high water absorption porous material and the water locking fiber, and the self-expansion high water absorption porous material and the water locking fiber. Antibacterial agents, for combating bacteria and viruses.

The self-expanding high water absorption porous material is obtained by a cross-linking reaction and a pore-forming reaction of polyhydroxy polymer and polysaccharide, wherein the polysaccharide comprises but is not limited to chitosan, alginate, glucan and plant polysaccharide. The water-locking fiber is one or more of modified polyacrylamide, sodium polyacrylate and polyacrylic resin fiber. The antibacterial agent or the antibacterial sol is one or more of inorganic salt antibacterial agent, organic antibacterial agent and sulfadiazine silver. The airtight waterproof viscous biological membrane is a modified cellulose gel membrane, alginate gel or chitosan gel. The polyhydroxy polymer is obtained by polymerizing a monomer with carbon-carbon double bonds and alcoholic hydroxyl groups through a copolymerization or homopolymerization method. The thickness of the dressing is 1 mm-5 mm, the imbibition rate is 1000% -2000%, the imbibition self-expansion rate is 1000% -3000%, the volume water locking rate is 50% -90%, and the generated negative pressure is-10 Pa-1000 Pa. The application field of the self-expanding super-absorbent water-locking micro negative pressure dressing is a wound surface and a wound which need to be drained, and specifically comprises but not limited to a burn wound surface, an ulcer wound surface, a diabetes wound surface, a chronic intractable wound surface, a surgical wound surface and an infected exudate wound surface.

As a specific example, as shown in fig. 1, the self-expanding super-absorbent water-locking micro negative pressure dressing obtained by the present invention is composed of a self-expanding high-absorbent porous material coupled with water-locking fibers and an airtight waterproof adhesive biological membrane, wherein the self-expanding high-absorbent water-locking porous material is in a three-dimensional open pore structure, and absorbs wound exudate through a water-absorbent water-locking layer, the absorbed wound exudate gradually expands, the porous material is gradually lifted, the closed space is gradually enlarged, a local part is formed relatively in vacuum, and a local absorption cavity of a sponge body generates a micro negative pressure suction effect on a wound and a deep soft tissue thereof, so that the effects of whole drainage and dressing suction of the wound exudate, no exudate residue, gradual tissue detumescence and local blood circulation promotion are achieved. Meanwhile, the self-expanding micro-negative pressure high-water-absorption water-locking dressing has good water-locking performance, absorbed seepage liquid cannot seep out for the second time, and continuous negative pressure can be generated, so that the blood microcirculation of wound tissues is promoted, inflammatory factors such as histamine, hydroxytryptamine, prostaglandin, bradykinin and the like accumulated on the part of the wound are taken away, the deepening of the wound is avoided, and the epithelialization of the wound is promoted.

Through a large number of experimental researches, the composite dressing which can generate different micro negative pressures, micro negative pressure durations and different water locking rates can be obtained by regulating the coupling degree of the water locking fibers and the porous material and the crosslinking state of the adhesive biomembrane.

The micro negative pressure of the micro negative pressure dressing is slightly reduced along with the increase of the coupling degree of the water-locking fiber and the porous material, but the crosslinking degree of the porous material and the viscous biomembrane is increased, so that the obtained micro negative pressure can be increased, and the duration of the micro negative pressure can be prolonged. In addition, the main factors capable of influencing the magnitude of the micro negative pressure also comprise the content of the water-locking fiber, the porosity and the pore diameter of the porous material, the mass fraction range of the water-locking fiber relative to the porous material is 10-50%, the water-locking fiber cannot play an effective water-locking role when the content is too low, and further the micro negative pressure is adversely influenced, and the content is higher than 50%, so that the pressure resistance of the composite material is reduced, the capacity of resisting external pressure is reduced, and the micro negative pressure is also not favorably generated. Therefore, when the mass fraction of the water-locking fiber is between 10% and 50%, the micro negative pressure of 100-104 Pa can be generated. The porosity of the porous material mainly influences the speed and the size of micro negative pressure generation through the liquid absorption rate; along with the increase of the porosity, the micro negative pressure generating speed of the micro negative pressure dressing is high, the micro negative pressure is increased, but the continuous increase of the porosity can cause the pressure resistance of the porous material to be poor, and the micro negative pressure to be reduced. The effect of pore size change on micro-negative pressure is close to porosity.

The self-expanding super-absorbent water-locking micro negative pressure dressing disclosed by the invention is used by selecting a composite dressing with a proper shape and performance according to the actual seepage volume, the wound size and the wound type.

The self-expanding super-absorbent water-locking micro-negative pressure dressing has the characteristics of

1. Self-expansion super-water-absorption water-locking micro-negative pressure dressing self-expansion to generate micro-negative pressure

The invention can generate micro negative pressure similar to an external negative pressure device through self imbibition expansion, and can continuously drain the effusion and the effusion in the deep layer of the wound. The specific process is that when the dressing absorbs wound exudate and gradually expands, the volume of the porous adsorption cavity is increased, the dressing is gradually lifted, the closed space is increased, the air pressure of the wound space sealed by the biological membrane is reduced, relative vacuum is locally formed, the vacuum formed here is positioned in the dressing and the space wrapped by the biological membrane, and micro negative pressure is generated in the microenvironment of the wound. The self-expanding high water absorption porous adsorption cavity coupled with the water locking fiber generates continuous micro negative pressure suction effect on the wound surface and the deep soft tissue thereof to absorb the wound surface seepage and achieve the purpose of integral drainage of the wound surface seepage.

2. Self-expansion super-water-absorption water-locking micro-negative pressure dressing high-liquid-absorption water-locking

Different from the traditional dressing, the water-locking fiber containing the water-locking performance can control the loss of water, has the water evaporation rate similar to that of normal skin, can keep the moist and sealed microenvironment of a wound surface, and provides a proper healing environment for re-epithelialization. Different from common water-locking materials such as water-locking resin/water-locking gel and the like, the novel fibrous water-locking material adopted by the invention has larger specific surface area, stronger water-holding capacity and softer dressing.

3. Self-expanding super-absorbent water-locking micro-negative pressure dressing wound healing promotion

The invention has high imbibition performance and can absorb wound exudate; meanwhile, stable and continuous micro negative pressure can be generated through self expansion in the suction and infiltration process, and the deep exudate of the wound is drained, so that the wound surface can be healed more conveniently, and the healing time is shortened; biological mucosa and water locking performance can maintain the moist and sealed microenvironment of the wound surface, and create a microenvironment for re-epithelialization.

The use and the replacement of the self-expanding super water-absorbing water-locking micro negative pressure dressing of the invention:

the use method of the invention comprises the following steps: when the dressing is clinically and practically used, the wound surface or the wound is directly covered by the self-expanding super-water-absorbing water-locking micro negative pressure dressing, or the airtight waterproof viscous biological film is not used, the wound surface or the wound is covered by an integrated material formed by compounding the self-expanding high-water-absorbing porous material, the water-locking fiber and the antibacterial agent in the self-expanding super-water-absorbing water-locking micro negative pressure dressing alone, and then the wound surface or the wound is sealed by the medical adhesive plaster, so that an adsorption cavity is formed between the integrated material at the wound surface and the medical adhesive plaster/airtight waterproof viscous biological film, the volume of the adsorption cavity is increased along with the expansion of the sheet-shaped compressed foam material after imbibing, a cavity is formed between the adsorption cavity and the plaster, and the micro negative pressure is generated.

The specific method comprises the following steps: the dressing is cut to a proper shape, and after the dressing completely covers the wound surface, the dressing is ensured to be closely adhered to normal skin around the wound surface, and the air tightness is good.

The clinical replacement standard of the self-expanding super water-absorbing water-locking micro negative pressure dressing is as follows:

1. materials visible to the naked eye are obviously polluted, and exudates are accumulated;

2. the obvious swelling after the material is wetted or the finger pressing method indicates that the material is completely wetted;

3. the retention time reaches more than 72 h.

As a specific example, as shown in fig. 2, the invention further provides a preparation method of the self-expanding super water-absorbing and water-locking micro negative pressure dressing, which comprises the following specific preparation processes:

step one, preparing the self-expanding high water absorption porous material.

Weighing polyhydroxy polymer, mixing with distilled water, stirring to dissolve uniformly, and fully foaming the solution by adopting a supercritical gas foaming process. Adding a certain mass of cross-linking agent into the foamed solution, uniformly stirring, and then putting into a mould for forming to obtain the self-expanding high water-absorbing porous material.

Step two, compounding water-locking fiber and self-expanding high water absorption porous material

And (3) coupling the fiber with the water locking performance to the self-expanding high water-absorbing and water-locking porous material through a coupling reaction to obtain the self-expanding high water-absorbing and water-locking porous material.

Step three, self-expansion super water absorption and water locking micro negative pressure dressing forming

Compounding the airtight waterproof viscous biomembrane with good biocompatibility with the self-expansion high water absorption and water locking porous material to obtain the self-expansion super water absorption and water locking micro negative pressure dressing.

Step four, compounding antibacterial agent

The deeply washed sample is sterilized and then compounded with an antibacterial agent.

Step five, post-processing of self-expanding super water-absorbing water-locking micro negative pressure dressing

The self-expanding super-absorbent water-locking micro negative pressure dressing is cut into proper size and shape according to different positions of the wound or the wound on the human body, the size of the liquid seepage amount, the size of the wound and different types of the wound.

Example 1

And (3) placing the polyethylene glycol and the polyester into a reaction kettle, heating until the polyethylene glycol and the polyester are completely and uniformly mixed to obtain a mixed solution. Placing the mixed liquid in a closed reaction container, slowly introducing supercritical carbon dioxide gas into the container, and slowly stirring the liquid. And after bubbles with uniform sizes are formed in the solution, improving the stirring speed, placing the solution in a mold for molding, and cleaning a molded sample to obtain the self-expanding high-water-absorption porous material. The polyacrylamide is made into water-locking fiber with controllable length and thickness by a spinning process, and the water-locking fiber is coupled to the self-expanding high water-absorbing porous material by a coupling agent. Placing the porous material of the composite water-locking fiber into alginate solution, and adding low-concentration CaCl₂And (3) compounding the solution and the viscous biological membrane on the surface of the material through a crosslinking reaction. Deeply cleaning the crosslinked composite material, and then sterilizing by adopting a cobalt 60 irradiation sterilization method. And finally, compounding the cleaned and sterilized sample with the sulfadiazine silver cream, drying, and processing and forming to obtain the self-expanding super-absorbent water-locking micro-negative pressure dressing.

Example 2

Placing the polyvinyl alcohol and the waterborne polyurethane in a reaction kettle, heating until the polyvinyl alcohol and the waterborne polyurethane are completely and uniformly mixed to prepare a mixed solution. Placing the mixed liquid in a closed reaction container, slowly introducing supercritical carbon dioxide gas into the container, and slowly stirring the liquid. After bubbles with uniform size are formed in the solution, the stirring speed is increased, and the solution is placed at a low temperatureAnd (3) rapidly forming in a mould, and cleaning the formed sample for 3 times, wherein the water amount adopted in each cleaning is 20 times of the mass of the material, so that the self-expanding high-water-absorption porous material is obtained. The polyacrylamide is made into water-locking fiber with controllable length and thickness by a spinning process, and the water-locking fiber is coupled to the self-expanding high water-absorbing porous material by a coupling agent. Placing the porous material of the composite water-locking fiber into alginate solution, and adding low-concentration CaCl₂And (3) compounding the solution and the viscous biological membrane on the surface of the material through a crosslinking reaction. Deeply cleaning the crosslinked composite material, and then sterilizing by adopting a cobalt 60 irradiation sterilization method. And finally compounding the cleaned and sterilized sample with polyhexamethylene biguanide, and performing freeze drying and processing molding to obtain the self-expanding super-absorbent water-locking micro-negative pressure dressing.

Based on the problems of the traditional dressing and the concept of micro negative pressure drainage, the invention develops the self-expanding micro negative pressure high water absorption and water locking dressing which has the advantages of high liquid absorption, self expansion, micro negative pressure, water locking, good wound surface adhesiveness, good biocompatibility and infection resistance, and solves the problems that the traditional dressing and the traditional dressing have low liquid absorption rate, no water locking performance, frequent replacement, difficulty in removing deep seepage, lack of infection resistance and the like and cannot meet the actual requirements. Most importantly, the invention can generate stable micro negative pressure inside in the imbibing process, does not depend on external negative pressure equipment, and can automatically and continuously absorb the exudate which is difficult to flow out of the wound so as to accelerate the wound healing. The self-expanding super-absorbent water-locking micro negative pressure dressing can be cut into proper sizes and shapes according to the position of a wound or a wound on different parts of a human body, the size of the liquid seepage amount, the size of the wound and different types of the wound.

The self-expanding super-absorbent water-locking micro negative pressure dressing and the preparation method provided by the embodiment of the application are described in detail. The above description of the embodiments is only for the purpose of helping to understand the method of the present application and its core ideas; meanwhile, for a person skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.

As used in the specification and claims, certain terms are used to refer to particular components. As one skilled in the art will appreciate, manufacturers may refer to a component by different names. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. "substantially" means within an acceptable error range, and a person skilled in the art can solve the technical problem within a certain error range to substantially achieve the technical effect. The description which follows is a preferred embodiment of the present application, but is made for the purpose of illustrating the general principles of the application and not for the purpose of limiting the scope of the application. The protection scope of the present application shall be subject to the definitions of the appended claims.

It is also noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a good or system that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such good or system. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other like elements in a commodity or system that includes the element.

It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.

The foregoing description shows and describes several preferred embodiments of the present application, but as aforementioned, it is to be understood that the application is not limited to the forms disclosed herein, but is not to be construed as excluding other embodiments and is capable of use in various other combinations, modifications, and environments and is capable of changes within the scope of the application as described herein, commensurate with the above teachings, or the skill or knowledge of the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the application, which is to be protected by the claims appended hereto.