阅读说明：本技术 一种冻干系统及冻干方法 (Freeze-drying system and freeze-drying method ) 是由 刘乾峰 于 2021-09-18 设计创作，主要内容包括：本发明公开了一种冻干系统,包括搅拌装置、快速结晶装置、托盘输送机构和冻干装置,快速结晶装置包括喷液组件和设于喷液组件下方的结晶转筒,结晶转筒内外分别设有内冷凝机构和外冷凝机构,结晶转筒的下方设有刮料组件,托盘输送机构设于刮料组件的下方,喷液组件与搅拌装置通过管道连接。还公开了一种冻干方法,采用冻干系统进行,包括如下步骤：药液输送；快速结晶；刮料；冻干。本冻干系统及冻干方法具有能够快速结晶冻干,能够提高产品均匀性和生产效率等优点。(The invention discloses a freeze-drying system which comprises a stirring device, a quick crystallizing device, a tray conveying mechanism and a freeze-drying device, wherein the quick crystallizing device comprises a liquid spraying assembly and a crystallizing drum arranged below the liquid spraying assembly, an inner condensing mechanism and an outer condensing mechanism are respectively arranged inside and outside the crystallizing drum, a scraping assembly is arranged below the crystallizing drum, the tray conveying mechanism is arranged below the scraping assembly, and the liquid spraying assembly is connected with the stirring device through a pipeline. Also discloses a freeze-drying method which is carried out by adopting a freeze-drying system and comprises the following steps: conveying the liquid medicine; fast crystallization; scraping; and (5) freeze-drying. The freeze-drying system and the freeze-drying method have the advantages of being capable of quickly crystallizing and freeze-drying, improving the uniformity and the production efficiency of products and the like.)

1. A lyophilization system, characterized by: including agitating unit (1), quick crystallization device (3), tray conveying mechanism (4) and freeze-drying device (5), quick crystallization device (3) are including hydrojet subassembly (31) and crystallization rotary drum (32) of locating hydrojet subassembly (31) below, crystallization rotary drum (32) are equipped with interior condensation mechanism and outer condensation mechanism inside and outside respectively, the below of crystallization rotary drum (32) is equipped with scrapes material subassembly (33), the below of scraping material subassembly (33) is located in tray conveying mechanism (4), hydrojet subassembly (31) are connected through pipeline (6) with agitating unit (1).

2. The lyophilization system of claim 1, wherein: the liquid spraying assembly (31) comprises a liquid distributor (311) and a nozzle (312) provided with the bottom of the liquid distributor (311), and the liquid distributor (311) is connected with the stirring device (1) through a pipeline (6).

3. The lyophilization system of claim 2, wherein: the nozzle (312) is provided in plurality, and the nozzles (312) are arranged at intervals along the axial direction of the crystallizing drum (32).

4. The lyophilization system of claim 1, wherein: the internal condensing mechanism comprises a condensing cylinder (34), and the condensing cylinder (34) is sleeved in the crystallization rotating cylinder (32).

5. The lyophilization system of claim 1, wherein: the external condensation mechanism comprises an arc-shaped cold coagulation block (35), and the arc-shaped cold coagulation block (35) is arranged on the side of the crystallization rotary drum (32).

6. The lyophilization system of claim 1, wherein: and a liquid pump (61) is arranged on the pipeline (6).

7. The lyophilization system according to any one of claims 1 to 6, wherein: the freeze-drying system further comprises an isolator (2), and the quick crystallization device (3), the tray conveying mechanism (4) and the freeze-drying device (5) are arranged in the isolator (2).

8. The lyophilization system according to any one of claims 1 to 6, wherein: the tray conveying mechanism (4) comprises a conveying belt (41), a condensing plate (42) arranged in the conveying belt (41) and a tray (43) arranged on the conveying belt (41).

9. The lyophilization system according to any one of claims 1 to 6, wherein: the material blocking sleeve (7) is arranged on the periphery of the rapid crystallizing device (3), a feed opening (71) is arranged at the bottom of the material blocking sleeve (7), and the tray conveying mechanism (4) is arranged below the feed opening (71).

10. A lyophilization process, characterized by: the lyophilization system of any one of claims 1 to 9, comprising the steps of:

s1, liquid medicine delivery: the stirring device (1) conveys liquid medicine to the liquid spraying assembly (31) through a pipeline (6);

s2, rapid crystallization: the liquid spraying assembly (31) sprays the liquid medicine onto the crystallization drum (32), and the crystallization drum (32) enables the liquid medicine to be rapidly crystallized on the crystallization drum (32) under the cooling action of the internal condensation mechanism and the external condensation mechanism;

s3, scraping: the crystallized medicine rotates along with the crystallization drum (32) to the position of the scraping component (33), and the medicine particles are scraped by the scraping component (33);

s4, freeze-drying: the medicine particles fall on a tray conveying mechanism (4) and are then sent into a freeze-drying device (5) for freeze-drying.

Technical Field

The invention relates to the technical field of food and medicine packaging mechanical equipment, in particular to a freeze-drying system and a freeze-drying method.

Background

For the bulk drugs in a suspended state or easy to precipitate, if the liquid medicine is not crystallized and quickly frozen in an extremely short time, the non-uniformity of the solvent can be caused, so that the content of the subsequent medicinal powder is not uniform, the quality of the medicine is poor, and even the medicine is unqualified. The existing freeze-drying system generally comprises a freeze-drying tray and a freeze dryer, liquid medicine is filled into the freeze-drying tray and then is sent into the freeze dryer for freeze-drying, and the freeze-drying needs a long time. If adopt current freeze-drying system to freeze-dry to raw materials liquid, because the liquid medicine is deposited with liquid form for a long time in freeze-drying dish, liquid medicine layering about will probably causing influences the homogeneity of follow-up powder, causes the waste.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a freeze-drying system and a freeze-drying method which can be used for quickly crystallizing and freeze-drying and can improve the uniformity and the production efficiency of products.

In order to solve the technical problems, the invention adopts the following technical scheme:

the utility model provides a freeze-drying system, includes agitating unit, quick crystallization device, tray conveying mechanism and freeze-drying device, quick crystallization device includes the hydrojet subassembly and locates the crystallization rotary drum of hydrojet subassembly below, the crystallization rotary drum is equipped with interior condensation mechanism and outer condensation mechanism inside and outside respectively, the below of crystallization rotary drum is equipped with scrapes the material subassembly, tray conveying mechanism locates the below of scraping the material subassembly, the hydrojet subassembly passes through the pipe connection with agitating unit.

As a further improvement of the above technical solution:

the liquid spraying assembly comprises a liquid distributor and a nozzle arranged at the bottom of the liquid distributor, and the liquid distributor is connected with the stirring device through a pipeline.

The nozzle is provided with a plurality of nozzles, and the nozzles are arranged at intervals along the axial direction of the crystallization drum.

The internal condensation mechanism comprises a condensation cylinder, and the condensation cylinder is sleeved in the crystallization rotary cylinder.

The outer condensation mechanism comprises an arc-shaped condensation block, and the arc-shaped condensation block is arranged on the side of the crystallization rotary drum.

And a liquid pump is arranged on the pipeline.

The freeze-drying system further comprises an isolator, and the quick crystallization device, the tray conveying mechanism and the freeze-drying device are all arranged in the isolator.

The tray conveying mechanism comprises a conveying belt, a condensing plate arranged in the conveying belt and a tray arranged on the conveying belt.

The material blocking sleeve is arranged around the rapid crystallization device, a feed opening is formed in the bottom of the material blocking sleeve, and the tray conveying mechanism is arranged below the feed opening.

A freeze-drying method is carried out by adopting the freeze-drying system, and comprises the following steps:

s1, liquid medicine delivery: the stirring device conveys liquid medicine to the liquid spraying assembly through a pipeline;

s2, rapid crystallization: the liquid spraying assembly sprays the liquid medicine onto the crystallization drum, and the crystallization drum enables the liquid medicine to be rapidly crystallized on the crystallization drum under the cooling action of the inner condensation mechanism and the outer condensation mechanism;

s3, scraping: the crystallization drug rotates along with the crystallization rotary drum to the position of the scraping component, and the crystallization drug is scraped into drug particles by the scraping component;

s4, freeze-drying: the medicine particles fall on the tray conveying mechanism and are then conveyed into a freeze-drying device for freeze-drying.

Compared with the prior art, the invention has the advantages that:

the freeze-drying system of the invention comprises the following use processes: firstly, the liquid medicine is stirred in a stirring device to form a uniform solvent, secondly, the stirring device conveys the liquid medicine to a liquid spraying assembly through a pipeline, the liquid medicine forms liquid drops under the action of the liquid spraying assembly, the liquid drops fall on a crystallization drum, and the crystallization drum enables the liquid medicine to be rapidly crystallized on the crystallization drum under the cooling action of an inner condensation mechanism and an outer condensation mechanism (the liquid drops are rapidly absorbed on the crystallization drum to be crystallized); then, the crystallization drug rotates along with the crystallization rotary drum (the crystallization drug is covered on the outer wall of the crystallization rotary drum) to the position of the scraping component, and the crystallization drug is scraped into drug granules by the scraping component; and finally, the medicine particles fall on a tray conveying mechanism and are conveyed into a freeze-drying device for freeze-drying. After the liquid medicine is stirred by the stirring device to form uniform liquid medicine, the liquid medicine is timely sent to the liquid spraying assembly through the pipeline and then dripped on the crystallization drum for rapid crystallization, thereby avoiding the occurrence of the static layering phenomenon of the liquid medicine, and improving the crystallization freeze-drying speed and the uniformity and quality of products. Moreover, the freeze-drying system can be used for continuous granulation and freeze-drying, so that the production efficiency is improved. This freeze-drying system can quick crystallization freeze-drying, can improve product homogeneity and production efficiency.

According to the freeze-drying system, when the crystallization drum rotates, one side of the arc-shaped cold clot rotates from bottom to top, the crystallization drum is positioned at one side of the arc-shaped cold clot and quickly reaches the crystallization temperature below the crystallization temperature under the dual cooling action of the condensation cylinder and the inside and the outside of the arc-shaped cold clot, so that the part of the crystallization drum, which moves downwards from the arc-shaped cold clot, is just positioned below the liquid spraying component, and medicine drops are quickly crystallized when the medicine drops are dripped at the part.

According to the freeze-drying method, after the liquid medicine is stirred by the stirring device to form uniform liquid medicine, the liquid medicine is timely sent to the liquid spraying assembly through the pipeline and then dripped on the crystallization drum to be rapidly crystallized, the occurrence of the static layering phenomenon of the liquid medicine is avoided, and the crystallization freeze-drying speed and the uniformity and quality of products are improved. In addition, the freeze-drying method can be used for continuous granulation and freeze-drying, and the production efficiency is improved. The freeze-drying method can be used for quick crystallization and freeze-drying, and can improve the uniformity and the production efficiency of products.

Drawings

Fig. 1 is a schematic diagram of the structure of the lyophilization system of the present invention.

Fig. 2 is a schematic front view of the rapid crystallization device of the lyophilization system of the present invention.

Fig. 3 is a schematic side view of the locking mechanism of the lyophilization system of the present invention.

The reference numerals in the figures denote:

1. a stirring device; 2. an isolator; 3. a rapid crystallization device; 31. a liquid spray assembly; 311. a liquid separator; 312. a nozzle; 32. a crystallization drum; 33. a scraping component; 34. a condensing cylinder; 35. arc-shaped cold coagulation blocks; 4. a tray conveying mechanism; 41. a conveyor belt; 42. a condensing plate; 43. a tray; 5. a freeze-drying device; 6. a pipeline; 61. a liquid pump; 7. a material blocking sleeve; 71. and (4) a feed opening.

Detailed Description

The invention will be described in further detail below with reference to the drawings and specific examples.

The first embodiment is as follows:

fig. 1 to 3 show an embodiment of the freeze-drying system of the present invention, which includes a stirring device 1, a rapid crystallization device 3, a tray conveying mechanism 4 and a freeze-drying device 5, wherein the rapid crystallization device 3 includes a liquid spraying assembly 31 and a crystallization drum 32 disposed below the liquid spraying assembly 31, an inner condensation mechanism and an outer condensation mechanism are respectively disposed inside and outside the crystallization drum 32, a scraping assembly 33 is disposed below the crystallization drum 32, the tray conveying mechanism 4 is disposed below the scraping assembly 33, and the liquid spraying assembly 31 is connected to the stirring device 1 through a pipeline 6.

The use process comprises the following steps: firstly, the liquid medicine is stirred in the stirring device 1 to form a uniform solvent, secondly, the stirring device 1 conveys the liquid medicine to the liquid spraying assembly 31 through the pipeline 6, the liquid medicine forms liquid drops under the action of the liquid spraying assembly 31, the liquid drops fall on the crystallization drum 32, and the crystallization drum 32 enables the liquid medicine to be rapidly crystallized on the crystallization drum 32 under the cooling action of the inner condensation mechanism and the outer condensation mechanism (the liquid drops are rapidly absorbed on the crystallization drum 32 to be crystallized); then, the crystallization drug rotates with the crystallization drum 32 (the crystallization drug is coated on the outer wall of the crystallization drum 32) to the position of the scraping component 33, and the drug particles are scraped by the scraping component 33; finally, the medicine particles fall on the tray conveying mechanism 4 and are sent to the freeze-drying device 5 for freeze-drying. After the liquid medicine is stirred by the stirring device 1 to form uniform liquid medicine, the liquid medicine is timely sent to the liquid spraying assembly 31 through the pipeline 6 and then dripped on the crystallization drum 32 for rapid crystallization, thereby avoiding the occurrence of the static layering phenomenon of the liquid medicine, and improving the crystallization freeze-drying speed and the uniformity and quality of products. Moreover, the freeze-drying system can be used for continuous granulation and freeze-drying, so that the production efficiency is improved. This freeze-drying system can quick crystallization freeze-drying, can improve product homogeneity and production efficiency.

In this embodiment, as shown in fig. 2 and 3, the spray assembly 31 includes a dispenser 311 and a nozzle 312 provided at the bottom of the dispenser 311, and the dispenser 311 is connected to the stirring device 1 through a pipe 6. The plurality of nozzles 312 are provided, and the nozzles 312 are arranged at intervals in the axial direction of the crystallization drum 32. The liquid medicine in the liquid distributor 311 is dropped into the crystallization drum 32 through each nozzle 312, so as to avoid the liquid medicine from being concentrated at one position and influencing the crystallization speed. Preferably, the nozzles 312 are evenly spaced along the axis of the crystallization drum 32 so that the rate of crystallization on the crystallization drum 32 remains the same as long as the amount of each drop is the same from location to location along the axis of the top of the crystallization drum 32.

In this embodiment, as shown in FIG. 2, the internal condensing mechanism includes a condensing cylinder 34, and the condensing cylinder 34 is sleeved inside the crystallization drum 32, so that the crystallization drum 32 keeps cool in the peripheral wall during the rotation process. The external condensing mechanism includes an arc-shaped cold cake 35, and the arc-shaped cold cake 35 is provided on the side of the crystallization drum 32. The liquid spraying component 31 is arranged right above the crystallization drum 32, one side of the arc-shaped cold clot 35 of the crystallization drum 32 rotates from bottom to top when the crystallization drum is in rotating operation, one side of the arc-shaped cold clot 35 of the crystallization drum 32 rapidly reaches the crystallization temperature below under the dual cooling action of the inside and the outside of the condensation cylinder 34 and the arc-shaped cold clot 35, so that the part of the crystallization drum 32 moving out from the arc-shaped cold clot 35 is just positioned below the liquid spraying component 31, and the medicine drops are rapidly crystallized when the medicine drops at the part. Specifically, the crystallization drum 32 is rotated by a motor.

In this embodiment, as shown in fig. 1, a liquid pump 61 is provided on the pipe 6. The size of the liquid dropping of the liquid spraying component 31 can be uniformly dropped under the action of the liquid drawing pump 61, and the precision is controllable. Specifically, the liquid pump 61 is a peristaltic pump.

In this embodiment, as shown in fig. 1, the freeze-drying system further includes an isolator 2, and the rapid crystallization device 3, the tray conveying mechanism 4 and the freeze-drying device 5 are all disposed in the isolator 2.

In this embodiment, the tray conveying mechanism 4 includes a conveying belt 41, a condensation plate 42 provided in the conveying belt 41, and a tray 43 provided on the conveying belt 41. The condensing plate 42 in the conveyor belt 41 cools the tray 43 on the conveyor belt 41 to prevent the frozen particles collected in the tray 43 from being melted, and the tray 43 placed on the conveyor belt 41 is synchronously linked with the rotation of the crystallization drum 32 under the action of the conveyor belt 41 to ensure that the frozen particles shoveled by the scraper assembly 33 are uniformly distributed in the tray 43.

In this embodiment, as shown in fig. 2, the material blocking sleeve 7 is arranged around the rapid crystallization device 3, the feed opening 71 is arranged at the bottom of the material blocking sleeve 7, and the tray conveying mechanism 4 is arranged below the feed opening 71. The crystal falling medicine before the crystal drum 32 falls on the tray 43 where the frozen particles are collected. The scraping component 33 is fixed on the material blocking sleeve 7.

Example two:

a freeze-drying method is carried out by adopting the freeze-drying system, and comprises the following steps:

s1, liquid medicine delivery: the stirring device 1 conveys the liquid medicine to the liquid spraying assembly 31 through a pipeline 6;

s2, rapid crystallization: the liquid spraying assembly 31 sprays the liquid medicine onto the crystallization drum 32, and the crystallization drum 32 enables the liquid medicine to be rapidly crystallized on the crystallization drum 32 under the cooling action of the inner condensation mechanism and the outer condensation mechanism;

s3, scraping: the crystallized medicine rotates along with the crystallization drum 32 to the position of the scraping component 33, and is scraped into medicine particles by the scraping component 33;

s4, freeze-drying: the medicine particles fall on the tray conveying mechanism 4 and are then sent into the freeze-drying device 5 for freeze-drying.

Firstly, the liquid medicine is stirred in the stirring device 1 to form a uniform solvent, the stirring device 1 conveys the liquid medicine to the liquid spraying assembly 31 through the pipeline 6, the liquid medicine forms liquid drops under the action of the liquid spraying assembly 31, the liquid drops fall on the crystallization drum 32, and the crystallization drum 32 enables the liquid medicine to be rapidly crystallized on the crystallization drum 32 under the cooling action of the internal condensation mechanism and the external condensation mechanism; secondly, the crystallization drug rotates along with the crystallization drum 32 to the position of the scraping component 33, and the drug particles are scraped by the scraping component 33; finally, the pellets fall on the tray 43 on the tray conveying mechanism 4, and the tray 43 with the collected pellets (pellets) is transferred to a freeze dryer plate layer in the freeze dryer 5 for freeze drying, sublimation drying. After the liquid medicine is stirred by the stirring device 1 to form uniform liquid medicine, the liquid medicine is timely sent to the liquid spraying assembly 31 through the pipeline 6 and then dripped on the crystallization drum 32 for rapid crystallization, thereby avoiding the occurrence of the static layering phenomenon of the liquid medicine, and improving the crystallization freeze-drying speed and the uniformity and quality of products. In addition, the freeze-drying method can be used for continuous granulation and freeze-drying, and the production efficiency is improved. The freeze-drying method can be used for quick crystallization and freeze-drying, and can improve the uniformity and the production efficiency of products.

Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make numerous possible variations and modifications to the present invention, or modify equivalent embodiments to equivalent variations, without departing from the scope of the invention, using the teachings disclosed above. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical spirit of the present invention should fall within the protection scope of the technical scheme of the present invention, unless the technical spirit of the present invention departs from the content of the technical scheme of the present invention.