阅读说明：本技术 个人护理组合物 (Personal care compositions ) 是由 范爱星 托马斯·博伊德 乐兰 于 2018-12-06 设计创作，主要内容包括：本文描述了包含固体乙烯基吡咯烷酮/乙酸乙烯酯共聚物、乙烯基吡咯烷酮/乙酸乙烯酯共聚物和化妆品可接受的载体的个人护理组合物。还描述了其制备和使用方法。(Described herein are personal care compositions comprising a solid vinylpyrrolidone/vinyl acetate copolymer, a vinylpyrrolidone/vinyl acetate copolymer, and a cosmetically acceptable carrier. Methods of making and using the same are also described.)

1. A personal care composition for reducing exposure of gaseous contaminants to skin, the personal care composition comprising:

(a) solid vinylpyrrolidone/vinyl acetate copolymer;

(b) vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent; and

(c) a cosmetically acceptable carrier.

2. The personal care composition of claim 1, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 8:1 to about 1: 3.

3. The personal care composition of claim 1 or claim 2, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 6:1 to about 0.4: 1.

4. The personal care composition of claim 1, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 3:1 to about 1: 1.

5. The personal care composition of any preceding claim, wherein the copolymer of (a) to (b) is present in a weight ratio of about 3: 1.

6. The personal care composition of any preceding claim, wherein the copolymer of (a) to (b) is present in a weight ratio of about 1: 3.

7. The personal care composition of any preceding claim, wherein the copolymer of (a) to (b) is present in a weight ratio of about 1: 1.

8. The personal care composition of any preceding claim, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in a range of from about 10,000g/mol to about 100,000 g/mol.

9. The personal care composition of any preceding claim, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in a range of from about 30,000g/mol to about 70,000 g/mol.

10. The personal care composition of any preceding claim, wherein the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent is in a range of from about 10,000g/mol to about 100,000 g/mol.

11. The personal care composition of any preceding claim, wherein the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent is in a range of from about 30,000g/mol to about 70,000 g/mol.

12. The personal care composition of any preceding claim, wherein the solvent is selected from the group consisting of alcohols, esters, ketones, and mixtures thereof.

13. The personal care composition of any preceding claim, wherein the solvent is selected from the group consisting of ethanol, n-propanol, iso-propanol, methyl acetate, ethyl acetate, methyl propionate, ethyl propionate, acetone, methyl ethyl ketone, 3-pentanone, and mixtures thereof.

14. The personal care composition of any preceding claim, wherein the solvent is ethanol.

15. The personal care composition of any preceding claim, wherein the composition further comprises water, a humectant, a preservative, an exfoliating agent, a lubricant, an emollient, and an emulsifier.

16. The personal care composition of any preceding claim, wherein the composition is selected from the group consisting of lotions, creams, ointments, balms, salves, and topical gels.

17. The composition of any one of the preceding claims, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer and the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

18. The personal care composition of any one of claims 1 to 16, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer.

19. The personal care composition of any one of claims 1 to 16, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% compared to a composition without the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

20. The personal care composition of any preceding claim, wherein (a) and (b) are mixed sequentially in the cosmetically acceptable carrier.

21. A method for reducing exposure of gaseous contaminants to mammalian skin, the method comprising applying to the skin of a mammal in need thereof a personal care composition comprising: (a) solid vinylpyrrolidone/vinyl acetate copolymer; (b) vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent; and (c) a cosmetically acceptable carrier.

22. The process of claim 21 wherein the copolymer of (a) and (b) is present in a weight ratio of about 8:1 to about 1: 3.

23. The process of claim 21 or claim 22, wherein the copolymer of (a) and (b) is present in a weight ratio of about 6:1 to about 0.4: 1.

24. The process of any one of claims 21 to 23, wherein the copolymer of (a) and (b) is present in a weight ratio of about 3:1 to about 1: 1.

25. The method of any one of claims 21 to 24, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in a range of from about 10,000g/mol to about 100,000 g/mol.

26. The method of any one of claims 21 to 25, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in a range of from about 30,000g/mol to about 70,000 g/mol.

27. The method of any one of claims 21 to 26, wherein the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent has a molecular weight in a range of from about 10,000g/mol to about 100,000 g/mol.

28. The method of any one of claims 21 to 27, wherein the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent has a molecular weight in a range of from about 30,000g/mol to about 70,000 g/mol.

29. The method of any one of claims 21 to 28, wherein the solvent is selected from the group consisting of alcohols, esters, ketones, and mixtures thereof.

30. The method of any one of claims 21 to 29, wherein the solvent is selected from the group consisting of ethanol, n-propanol, iso-propanol, methyl acetate, ethyl acetate, methyl propionate, ethyl propionate, acetone, methyl ethyl ketone, 3-pentanone, and mixtures thereof.

31. The method of any one of claims 21 to 30, wherein the solvent is ethanol.

32. The method of any one of claims 21 to 31, wherein the composition further comprises water, a humectant, a preservative, an exfoliating agent, a lubricant, an emollient, and an emulsifier.

33. The method of any one of claims 21 to 32, wherein the composition is a fully formulated topical lotion for reducing exposure of gaseous contaminants to the skin of a patient.

34. The method of any one of claims 21 to 33, wherein the 20 micron layer of the personal care composition reduces ozone transmission by at least 20% compared to a composition without a solid vinylpyrrolidone/vinyl acetate copolymer or a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

35. The method of any one of claims 21 to 33, wherein the 20 micron layer of the personal care composition reduces ozone transmission by at least 20% compared to a composition that does not comprise a solid vinylpyrrolidone/vinyl acetate copolymer.

36. The method of any one of claims 21-33 and 35, wherein the 20 micron layer of the personal care composition reduces ozone transmission by at least 20% compared to a composition that does not comprise vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

37. The method of any one of claims 21 to 36, wherein (a) and (b) are mixed sequentially in the cosmetically acceptable carrier.

Background

The number of people who die or suffer from serious illness due to air pollution exceeds any other environmental factor. Air pollution is associated with premature death of about 7 million people. Outdoor air pollution is associated with ischemic heart disease, stroke, chronic obstructive pulmonary disease, lung cancer and acute lower respiratory infections in children. Indoor air pollution is associated with childhood stroke, coronary artery disease, ischemic heart disease, chronic obstructive pulmonary disease, acute lower respiratory infection, and lung cancer.

Contaminants of interest include standard air pollutants. The standard air pollutants are six common air pollutants including ozone, carbon dioxide, nitrogen oxides, sulfur dioxide, particulate matter, and lead.

Many environmental pollutants are oxidants or catalyze the production of Reactive Oxygen Species (ROS), either directly or indirectly. ROS are believed to activate cell proliferation and/or cell survival signaling mechanisms, including mechanisms that can alter apoptosis and other regulatory pathways that may be involved in the pathogenesis of many skin conditions, including photosensitive diseases and some types of skin malignancies.

The skin has a series of defense mechanisms that interact with poisons to eliminate their harmful effects. These protection mechanisms include non-enzymatic and enzymatic molecules that act as potent antioxidant or oxidant degradation systems. Unfortunately, these homeostatic defenses, while highly effective, are limited in function and may be overwhelmed, resulting in an increase in ROS in the skin, which in turn may contribute to the development of dermatological diseases.

Despite the many advances made in the art of formulating lotions, many challenges still remain.

Disclosure of Invention

Some embodiments of the present invention relate to a topical composition comprising a combination of ingredients that will block the effects of gaseous contaminants on a patient's skin. In particular, the present invention relates to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion.

One of the advantages of the present invention is that topical compositions prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion exhibit a synergistic effect of reducing exposure to ozone transmission through the topical composition.

Vinylpyrrolidone/vinyl acetate copolymers are linear random copolymers resulting from the free radical polymerization of vinylpyrrolidone monomers and vinyl acetate monomers in a specific ratio.

The solid vinylpyrrolidone/vinyl acetate copolymer can be in the form of a powder, microspheres, flakes or pellets. In one embodiment, the solid vinylpyrrolidone/vinyl acetate copolymer is a powder.

The vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent can be dissolved in a weight ratio ranging from about 40% by weight to about 60% by weight. In one embodiment, the vinylpyrrolidone/vinyl acetate copolymer is dissolved in the solvent at about 50% by weight.

The molecular weight of the vinylpyrrolidone/vinyl acetate copolymer is in the range of about 10,000g/mol to about 100,000 g/mol.

The topical composition is prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.67: 1.

The vinylpyrrolidone/vinyl acetate copolymer is dissolved in a polar solvent. These solvents include solvents that are small molecule organic compounds containing atoms with lone electron pairs, such as oxygen or nitrogen. The solvent should not have a high degree of hydrocarbon-like character. Acceptable solvents include alcohols, esters, ketones, and water.

The remainder of the topical composition is any topical composition compatible with both the vinylpyrrolidone/vinyl acetate copolymer.

The topical composition is prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion. The step of preparing the topical composition comprises: a base skin lotion was prepared to which a solid vinylpyrrolidone/vinyl acetate copolymer was added, and then to which a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent was added. Alternatively, the step of preparing the topical composition comprises: a base skin lotion was prepared to which a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent was added, and then a solid vinylpyrrolidone/vinyl acetate copolymer was added thereto. The term "sequentially" means that the components (a) and (b) are not added simultaneously, but are added one after the other in any suitable order.

It has been observed that the solid vinylpyrrolidone/vinyl acetate copolymer exhibits about 11% ozone blocking when added at 1.0% by weight in the lotion. It has also been observed that the addition of 1.0 wt.% of vinylpyrrolidone/vinyl acetate copolymer dissolved in pure ethanol in the lotion showed about 10% ozone blocking. However, the addition of both solid vinylpyrrolidone/vinyl acetate copolymer and dissolved vinylpyrrolidone/vinyl acetate copolymer each at a level of 1 wt% in the lotion exhibited an ozone block of about 32%. The ozone blocking capacity of lotions comprising solid vinylpyrrolidone/vinyl acetate copolymer and dissolved vinylpyrrolidone/vinyl acetate copolymer is an unusual and unexpectedly large improvement. This large improvement is repeatable and statistically significant.

The present invention also relates to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

The method comprises the steps of placing the topical composition onto a small portion of the skin of a patient and spreading the topical composition onto a larger area of the skin of the patient to form a layer of the topical composition; or the steps of placing the topical composition on the hands of a patient and spreading the topical composition over a larger area of the patient's skin to form a layer of the topical composition; or the steps of placing the topical composition onto a device and spreading the topical composition onto a larger area of the patient's skin to form a layer of the topical composition.

The present invention is defined in at least thirty-two aspects.

In a first aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

In a second aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 8:1 to about 0.4: 1.

In a third aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 6:1 to about 0.67: 1.

In a fourth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 3:1 to about 1: 1.

In a fifth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in a range of from about 10,000g/mol to about 100,000 g/mol.

In a sixth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in a range of from about 30,000g/mol to about 70,000 g/mol.

In a seventh aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent has a molecular weight in a range of from about 10,000g/mol to about 100,000 g/mol.

In an eighth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent has a molecular weight in a range of from about 30,000g/mol to about 70,000 g/mol.

In a ninth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solvent is selected from the group consisting of alcohols, esters, ketones, and mixtures thereof.

In a tenth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solvent is selected from the group consisting of ethanol, n-propanol, iso-propanol, methyl acetate, ethyl acetate, methyl propionate, ethyl propionate, acetone, methyl ethyl ketone, 3-pentanone, and mixtures thereof.

In an eleventh aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in ethanol.

In a twelfth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the composition further comprises water, a humectant, a preservative, an exfoliating agent, a lubricant, an emollient, and an emulsifier.

In a thirteenth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the composition is a fully formulated topical lotion for reducing exposure of gaseous contaminants to a patient's skin.

In a fourteenth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer and the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent.

In a fifteenth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer.

In a sixteenth aspect, the present invention is directed to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% compared to a composition without the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent.

In a seventeenth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

In an eighteenth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 8:1 to about 0.4: 1.

In a nineteenth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 6:1 to about 0.67: 1.

In a twentieth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the copolymer of (a) and (b) is present in a weight ratio of from about 3:1 to about 1: 1.

In a twenty-first aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in the range of from about 10,000g/mol to about 100,000 g/mol.

In a twenty-second aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solid vinylpyrrolidone/vinyl acetate copolymer has a molecular weight in the range of from about 30,000g/mol to about 70,000 g/mol.

In a twenty-third aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent has a molecular weight in the range of from about 10,000g/mol to about 100,000 g/mol.

In a twenty-fourth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent has a molecular weight in the range of from about 30,000g/mol to about 70,000 g/mol.

In a twenty-fifth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solvent is selected from the group consisting of alcohols, esters, ketones, and mixtures thereof.

In a twenty-sixth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solvent is selected from the group consisting of ethanol, n-propanol, iso-propanol, methyl acetate, ethyl acetate, methyl propionate, ethyl propionate, acetone, methyl ethyl ketone, 3-pentanone, and mixtures thereof.

In a twenty-seventh aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the solvent is ethanol.

In a twenty-eighth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the composition further comprises water, a humectant, a preservative, an exfoliating agent, a lubricant, an emollient, and an emulsifier.

In a twenty-ninth aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the composition is a fully formulated topical lotion for reducing exposure of gaseous contaminants to the skin of a patient.

In a thirty-first aspect, the present invention is directed to a method for reducing exposure of skin to gaseous contaminants in a patient comprising applying to an area of skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% as compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer and the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent.

In a thirty-first aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% as compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer.

In a thirty-second aspect, the present invention is directed to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein a 20 micron layer of the composition reduces ozone transmission by at least 20% as compared to a composition without the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent.

Detailed Description

For purposes of illustration, the principles of the invention have been described with reference to various exemplary embodiments thereof. Although certain embodiments of the present invention are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable and can be employed in other devices and methods. Before explaining the disclosed embodiments of the present invention in detail, it is to be understood that the invention is not limited in its application to the details of any particular embodiment shown. The terminology used herein is for the purpose of description and not of limitation. Further, while certain methods are described with reference to certain steps being presented herein in certain order, in many cases, these steps may be performed in any order as would be understood by one of ordinary skill in the art, and the methods are not limited to the particular arrangement of steps disclosed herein.

As used herein and in the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Any class member in the singular refers not only to one chemical species within the class, but also to mixtures of such chemical species; for example, the term "polymer" in the singular may refer to a mixture of compounds each of which is also a polymer. The terms "a" (or "an"), "one or more" and "at least one" are used interchangeably herein. The terms "comprising," "including," and "having" are used interchangeably.

When referring to a member of the markush group, wherein the member is in plural form, any species of the member is referred to. For example, the expression "solvent is selected from alcohols, … …" means that the solvent can be a single alcohol (e.g., ethanol) or a mixture of alcohols.

Abbreviations and symbols used herein have their usual meaning unless otherwise indicated. The term "wt%" refers to a percentage by weight. The symbol "ppb" refers to parts per billion. The unit "g/mol" refers to grams per mole and the unit "mg" refers to milligrams. The characters "α", "β" and "γ" are the greek letters alpha, beta and gamma, respectively.

The symbols "-", "═ and superscript" in the chemical formulae "^–"independently refers to a single bond, a double bond, a negative charge; the symbols "-" and "═ in the mathematical context mean minus and equal, respectively. In referring to chemical structures and names, the symbols "H", "C" and "O" are the chemical symbols for hydrogen, carbon and oxygen, respectively.

Brackets for bracketing species, e.g. [ O ]₃]", indicates the concentration of the species listed in brackets. The concentration may be expressed in mol/L or ppb.

The term "about" when referring to a number means ± 10%. For example, the expression "about 30,000" refers to a number between 27,000 and 33,000 and including 27,000 and 33,000.

Ranges are used throughout as a shorthand way of describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range.

The term "polymer", for example in the expression "acrylic polymer", is to be interpreted broadly. Examples of polymers include both homopolymers (polymers comprising a single monomer species) and copolymers. The term "copolymer" refers to a polymer comprising more than one species of monomer. The copolymers of the present invention consist of or consist essentially of one or more linear chain copolymers.

In some embodiments, the present invention relates to a topical composition comprising a combination of ingredients that will block the effects of gaseous contaminants on a patient's skin.

In other embodiments, the present invention relates to a topical composition for reducing exposure of gaseous contaminants to skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

One of the advantages of the present invention is that topical compositions prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion exhibit a synergistic effect of reducing exposure to ozone transmission through the topical composition.

Vinylpyrrolidone/vinyl acetate copolymers are linear random copolymers resulting from the free radical polymerization of vinylpyrrolidone monomers and vinyl acetate monomers in a specific ratio.

The vinylpyrrolidone/vinyl acetate copolymer may be abbreviated as PVP/VA or PVP/VA copolymer and may be referred to as poly (1-vinylpyrrolidone-co-vinyl acetate).

The vinylpyrrolidone/vinyl acetate copolymer has the formula [ CH₂–CHR]_xWhere R is pyrrolidone bound to the polymer chain via the nitrogen of the pyrrolidone or is an acetate group. The variable x varies with the length of the molecule, but is generally from about 200 to 1000. Alternatively, the vinylpyrrolidone/vinyl acetate copolymer has the formula- [ CH ]₂–CHY]_m–[CH₂＝CH(–O–CO–CH₃)]_n-wherein Y is pyrrolidone bonded to the polymer chain via the nitrogen of the pyrrolidone.

Pyrrolidones consist of five-membered rings containing an amide group. Vinylpyrrolidone consists of a five-membered ring containing an amide group, the nitrogen of which is also bonded to the vinyl group.

Acetate group formed by the group-O-CO-CH₃And (4) forming.

The vinylpyrrolidone/vinyl acetate copolymer can be obtained from any suitable commercial source, including Ashland, BASF, GAF Materials Corp, Shanghai Yuking Water solvent Materials Tech Co., Dalian Biochemistry Co., and Hefei Joye Import & Export Co.

The present invention relates to a topical composition prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion.

The solid vinylpyrrolidone/vinyl acetate copolymer can be in the form of a powder, microspheres, flakes or pellets. In one embodiment, the solid vinylpyrrolidone/vinyl acetate copolymer is a powder.

The vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent can be dissolved in a weight ratio ranging from about 40% by weight to about 60% by weight. In one embodiment, the vinylpyrrolidone/vinyl acetate copolymer is dissolved in the solvent at about 50% by weight.

In one embodiment, the solid vinylpyrrolidone/vinyl acetate copolymer is the same as the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent. In another embodiment, the solid vinylpyrrolidone/vinyl acetate copolymer is similar to the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent. In another embodiment, the solid vinylpyrrolidone/vinyl acetate copolymer is different from the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent.

The expression "solid vinylpyrrolidone/vinyl acetate copolymer" is intended to indicate that the particular vinylpyrrolidone/vinyl acetate copolymer is added as a solid to a skin lotion, rather than to indicate that the vinylpyrrolidone/vinyl acetate copolymer must be solid in a lotion. Similarly, the expression "vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent" is intended to indicate that the particular vinylpyrrolidone/vinyl acetate copolymer is dissolved in a solvent for addition to a skin lotion, rather than to indicate that the vinylpyrrolidone/vinyl acetate copolymer must be in a solvent in a lotion. Modification in the expression "solid vinylpyrrolidone/vinyl acetate copolymer" the term "solid" and the modification in the expression "vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent" the expression "dissolved in a solvent" are in each case an indication of the origin of the copolymer and not necessarily its state in the lotion.

The molecular weight of the vinylpyrrolidone/vinyl acetate copolymer is in the range of about 10,000g/mol to about 100,000 g/mol. This refers to solid vinylpyrrolidone/vinyl acetate copolymers, vinylpyrrolidone/vinyl acetate copolymers dissolved in a solvent and both vinylpyrrolidone/vinyl acetate copolymers.

In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in a range of from about 10,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 50,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 40,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 30,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 20,000 g/mol.

In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 50,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 40,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 20,000g/mol to about 30,000 g/mol.

In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 50,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 40,000 g/mol.

In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 40,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 40,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 40,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 40,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 40,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 40,000g/mol to about 50,000 g/mol.

In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in a range of from about 50,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 50,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 50,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 50,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 50,000g/mol to about 60,000 g/mol.

In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 60,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 60,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 60,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 60,000g/mol to about 70,000 g/mol.

In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 70,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 70,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 70,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 80,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 80,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 90,000g/mol to about 100,000 g/mol.

In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 50,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 40,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 30,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 10,000g/mol to about 20,000 g/mol.

In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 50,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 40,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 20,000g/mol to about 30,000 g/mol.

In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 30,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 30,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 30,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 30,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 30,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 30,000g/mol to about 50,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 30,000g/mol to about 40,000 g/mol.

In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 40,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 40,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 40,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 40,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 40,000g/mol to about 60,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 40,000g/mol to about 50,000 g/mol.

In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 50,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 50,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 50,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 50,000g/mol to about 70,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 50,000g/mol to about 60,000 g/mol.

In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 60,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 60,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 60,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 60,000g/mol to about 70,000 g/mol.

In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 70,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 70,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 70,000g/mol to about 80,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 80,000g/mol to about 100,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 80,000g/mol to about 90,000 g/mol. In one embodiment, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in a range of from about 90,000g/mol to about 100,000 g/mol.

The weight ratio of vinylpyrrolidone units to vinyl acetate units present in each vinylpyrrolidone/vinyl acetate copolymer was determined during the preparation of the copolymer.

In one embodiment, the weight ratio of vinylpyrrolidone units to vinyl acetate units present in the solid vinylpyrrolidone/vinyl acetate copolymer is in a range of from about 20:80 to 80: 20. In one embodiment, the weight ratio of vinylpyrrolidone units to vinyl acetate units present in the solid vinylpyrrolidone/vinyl acetate copolymer is in a range of from about 30:70 to 50: 50. In one embodiment, the weight ratio of vinylpyrrolidone units to vinyl acetate units present in the solid vinylpyrrolidone/vinyl acetate copolymer is in a range of from about 50:50 to 70: 30. In one embodiment, the weight ratio of vinylpyrrolidone units to vinyl acetate units present in a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent is in a range of from about 20:80 to 80: 20. In one embodiment, the weight ratio of vinylpyrrolidone units to vinyl acetate units present in a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent is in a range of from about 30:70 to 50: 50. In one embodiment, the weight ratio of vinylpyrrolidone units to vinyl acetate units present in a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent is in a range of from about 50:50 to 70: 30.

The present invention relates to a topical composition prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion. In some embodiments, the amount of polymer content of (a) and (b) is about equal. In other embodiments, the amount of polymer content of (a) is greater than the amount of polymer content of (b). In other embodiments, the amount of polymer content of (a) is less than the amount of polymer content of (b).

The expression "weight ratio of the copolymer contents of (a) and (b)" means the ratio of the weight of the solid vinylpyrrolidone/vinyl acetate copolymer to the weight of the vinylpyrrolidone/vinyl acetate copolymer present in the solution of vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent. This means that the ratio is the ratio of the copolymer itself, which is adjusted for the solvent. Thus, for example, if the level of solid vinylpyrrolidone/vinyl acetate copolymer is 1.0% by weight and the level of vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent is also 1.0% by weight, the solution of vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent and solvent comprises 50% by weight of vinylpyrrolidone/vinyl acetate copolymer; the effective dosage level adjusted for the solvent is 1.0 wt% to 0.50 wt% or 2: 1.

In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.67: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.8: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 1: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 2: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 3: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 6: 1.

In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 0.67: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 0.8: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 1: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 2: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 3: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 6:1 to about 4: 1.

In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 4:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 4:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 4:1 to about 0.67: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 4:1 to about 0.8: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 4:1 to about 1: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 4:1 to about 2: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 4:1 to about 3: 1.

In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 3:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 3:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 3:1 to about 0.67: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 3:1 to about 0.8: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 3:1 to about 1: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 3:1 to about 2: 1.

In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 2:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 2:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 2:1 to about 0.67: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 2:1 to about 0.8: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 2:1 to about 1: 1.

In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 1:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 1:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 1:1 to about 0.67: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 1:1 to about 0.8: 1.

In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 0.8:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 0.8:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 0.8:1 to about 0.67: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 0.67:1 to about 0.4: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 0.67:1 to about 0.5: 1. In one embodiment, the copolymer of (a) to (b) is present in a weight ratio of about 0.5:1 to about 0.4: 1.

The present invention relates to a topical composition prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion. The definition of the term "solvent" includes any fluid that completely dissolves the vinylpyrrolidone/vinyl acetate copolymer of (b). In one embodiment, the solvent is a cosmetically acceptable solvent.

The vinylpyrrolidone/vinyl acetate copolymer is dissolved in a polar solvent. These solvents include solvents that are small molecule organic compounds containing atoms with lone electron pairs, such as oxygen or nitrogen. The solvent should not have a high degree of hydrocarbon-like character. Acceptable solvents include alcohols, esters, ketones, and water.

In one embodiment, the solvent is selected from the group consisting of alcohols, esters, and ketones.

Alcohols include primary and secondary alcohols. Examples of alcohols include methanol CH₃OH, ethanol CH₃–CH₂-OH, n-propanol CH₃–CH₂–CH₂-OH, isopropyl alcohol (isopropanol) CH₃–CH(OH)–CH₃And mixtures thereof.

The ester comprises methyl acetate CH₃–CO–O–CH₃Ethyl acetate CH₃–CO–O–CH₂–CH₃Methyl propionate CH₃–CH₂–CO–O–CH₃Ethyl propionate CH₃–CH₂–CO–O–CH₂–CH₃And mixtures thereof.

The ketone comprises acetone CH₃–CO–CH₃Methyl ethyl ketone CH₃–CO–CH₂–CH₃3-pentanone CH₃–CH₂–CO–CH₂–CH₃And mixtures thereof.

In one embodiment, the solvent is ethanol.

The present invention relates to a topical composition for reducing exposure of gaseous contaminants to the skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent. The remainder of the topical composition is any topical composition compatible with both the vinylpyrrolidone/vinyl acetate copolymer.

The topical composition may be a skin lotion. Skin lotions are stable or semi-stable mixtures of oil, water and ingredients miscible therein. The most used level of ingredient is usually water. Oils may be used to provide a moisturizing effect to the skin of a patient. Moisturization can occur in a variety of ways, including changing the feel of the skin, attracting water to the skin, and blocking the escape of water from the skin. When placed on the skin, the lotion interacts with the skin surface to provide a soothing sensation. Over time, the occlusive agent in the lotion formulation prevents water from leaving the skin, which helps to accumulate moisture in the skin. This additional moisture ultimately alleviates the problems associated with dry skin.

The mixture of water, oil, and other ingredients that form the skin lotion formulation is formulated to provide a homogeneous mixture, such as an emulsion. Additional ingredients include ingredients that can be described by their function in an emulsion, such as diluents, thickeners, humectants, preservatives, neutralizing agents, emulsifiers, co-emulsifiers, emollients, occlusive agents, fragrances, and colorants. Some ingredients may have more than one function in a skin lotion.

A common moisturizing ingredient is an occlusive agent, which creates a barrier that blocks water from escaping the skin. Examples of occlusive agents include petrolatum, fatty alcohols (such as cetyl and stearyl alcohols), hydrocarbon oils (such as mineral oil), silicones (such as dimethicone and cyclomethicone), squalene, wax esters (such as beeswax and lanolin; vegetable waxes (such as candelilla, carnauba and palm kernel), vegetable based oils (such as olive, rice bran, macadamia, castor, soybean, shea butter), cholesterol and lecithin.

The lotion may contain a humectant, which is an ingredient that attracts water. Humectants attract and retain moisture from the surrounding air via absorption, drawing water vapor into or below the upper surface of the patient's skin. Humectants typically have hydroxyl groups that allow them to participate in hydrogen bonding to attract water. This process draws moisture from the outer layers of the skin or from the atmosphere at high humidity. The water is then trapped by the epidermis. Examples of humectants include triethylene glycol, tripropylene glycol, propylene glycol, glycerin, polyethylene glycol, PPG, glycerin, sorbitol, hexylene glycol, butylene glycol, urea, silicone, collagen, aloe vera, honey, and hyaluronic acid.

The lotion formulation may further comprise an emollient. Emollients are ingredients that will improve the feel of the lotion on the skin. Emollients reduce the stickiness and oiliness caused by other moisturizing ingredients. Examples of common emollients include coconut oil, cetyl esters, selected silicone oils, shea butter, cocoa butter, mineral oil, lanolin, petrolatum, paraffin wax, beeswax, squalene, coconut oil, jojoba oil, sesame oil, almond oil, cetyl alcohol, olive oil, oleic acid and triisocaprylic glyceride.

The lotion can also include an emulsifier. Emulsifiers are ingredients that will improve the stability of a mixture of oil material and water. Examples of common emulsifiers include glyceryl stearate and stearic acid. Other examples of emulsifiers include acacia seyal octenyl succinate, C_12-18Acid triglyceride, acrylate crosslinkingPolymer-4, Adinandra milletii seed oil PEG-8 ester, Adinandra milletii seed oil polyglycerol-6 ester, almond oil glycerol polyether-8 ester, almond oil PEG-6 ester, almond oil PEG-8 ester, sweet almond oil polyglycerol-4 ester, sweet almond oil polyglycerol-6 ester, aluminum lanolate, C_6-16Ammonium perfluoroalkylethyl phosphate, ammonium cocoate sulfate, ammonium isostearate, ammonium oleate, ammonium perfluorohexylethyl phosphate, ammonium shellac, ammonium stearate, ammonium tallate, AMPD-isostearoyl hydrolyzed collagen, AMPD-rosin hydrolyzed collagen, PEG-6 ester of apricot kernel oil, PEG-8 ester of apricot kernel oil, PEG-40 ester of apricot kernel oil, polyglycerin-3 ester of apricot kernel oil, polyglycerin-4 ester of apricot kernel oil, polyglycerin-5 ester of apricot kernel oil, polyglycerin-6 ester of apricot kernel oil, polyglycerin-10 ester of apricot kernel oil, arachidylic acid, arachidonol glucoside, PEG-8 ester of argyl oil, polyglycerin-6 ester of star palm oil, avocado amide DEA, DIPA, PEG-8 ester of avocado oil, propylene glycol ester of avocado oil, polyether-8 ester of babassu oil, and mixtures thereof, Babassu oil polyglycerol-6 ester, babassu amidopropyl trimethyl ammonium chloride, babassu amidopropyl trimethyl ammonium methosulfate, behenamidopropyl dimethylamine, behenyl polyether-2, behenyl polyether-5, behenyl polyether-10, behenyl polyether-15, behenyl polyether-20, behenyl polyether-25, behenyl polyether-30, behenyl stearic acid, behenyl PG-trimethyl ammonium chloride, benzenesulfonyl trimethylol formamide, brasiliensis seed oil polyglycerol-6 ester, borage seed oil PEG-8 ester, borage seed oil polyglycerol-4 ester, borage seed oil polyglycerol-6 ester, butylphenol polyether-19 carboxylic acid, butylphenol polyether-5 carboxylic acid, butyloctanoic acid, bis-isobutyl PEG/PPG-10/7/dimethyl siloxane copolymer, Bis-butyldimethylsiloxane polyglycerol-3, butyldimethylhydroxypropyl butyl glucoside ammonium chloride, butyldimethylhydroxypropyl lauryl glucoside ammonium chloride, butylene glycol behenate, butylene glycol cocoate, butylene glycol isostearate mixture, butylene glycol laurate, butylene glycol myristate, butylene glycol stearate, butyl glucoside decanoate, butyl glucoside hydroxypropyl trimonium chloride, C_1-5Alkyl galactomannan, C_10-16Alkyl glucoside, C_10-18Triglyceride polyglycerol-3 phosphate ester, C_10-30Cholesterol/lanosterol esters, C_10-40Isoalkyl glycerides, C_11-13Alkanol polyether-6, C_11-13Alkanopolyether-9, C_11-13Alkanol polyether-10, C_11-15Alkanol polyether-3, C_11-15Alkanol polyether-5, C_11-15Alkanopolyether-7, C_11-15Alkanopolyether-9, C_11-15Alkanol polyether-12, C_11-15Alkanol polyether-15, C_11-15Alkanol polyether-20, C_11-15Alkanol polyether-30, C_11-15Alkanolpolyether-3-oleate, C_11-15Alkanolpolyether-7-carboxylic acid, C_11-15Secondary alkanol polyether-12, C_11-21Alkanol polyether-3, C_11-21Alkanol polyether-10, C_12-13Alkanol polyether-2, C_12-13Alkanol polyether-3, C_12-13Alkanopolyether-4, C_12-13Alkanol polyether-5, C_12-13Alkanol polyether-6, C_12-13Alkanopolyether-7, C_12-13Alkanopolyether-9, C_12-13Alkanol polyether-10, C_12-13Alkanol polyether-15, C_12-13Alkanopolyether-23, C_12-13Alkanolpolyether-10-phosphate esters, C_12-14Alkyldiaminoethylglycine HCl, C_12-14Alkanopolyether-7, C_12-14Alkanol polyether-12, C_12-14Alkanol polyether-3, C_12-14Secondary alkanol polyether-3, C_12-14Secondary alkanol polyether-5, C_12-14Secondary alkanol polyether-7, C_12-14Secondary alkanol polyether-8, C_12-14Secondary alkanol polyether-9, C_12-14Secondary alkanol polyether-12, C_12-14Secondary alkanol polyether-15, C_12-14Secondary alkanol polyether-20, C_12-14Secondary alkanol polyether-30, C_12-14Secondary alkanol polyether-40, C_12-14Secondary alkanol polyether-50, C_12-15Alkanol polyether-12, C_12-15Alkanol polyether-2, C_12-15Alkanolpolyether-2-phosphate, C_12-15Alkanolpolyether-3-phosphate, C_12-15Alkanopolyether-4, C_12-15Alkanol polyether-5, C_12-15Alkanol polyether-6Phosphoric acid ester, C_12-15Alkanolpolyether-8-carboxylic acid, C_12-15Alkanolpolyether-8-phosphate, C_12-15Alkanolpolyether-9-phosphate, C_12-15Alkanol polyether-10, C_12-15Alkanolpolyether-10-phosphate esters, C_12-15Alkanopolyether-11, C_12-15Alkanol polyether-3, C_12-15Alkanopolyether-7, C_12-15Alkanopolyether-9, C_12-15Alkanolpolyether-9 hydrogenated tallow oleate, C_12-16Alkanol polyether-5, C_12-16Alkanolpolyether-6-phosphate, C_12-16Alkanopolyether-7, C_12-16Alkanopolyether-9, C_12-20Acid PEG-8 ester, C_12-20Alkyl glucoside, C_14-15Alkanopolyether-4, C_14-15Alkanopolyether-7, C_14-15Alkanopolyether-11, C_14-15Alkanol polyether-12, C_14-15Alkanol polyether-13, C_14-16Diol palmitate, C_18-20Diol isostearate, C_18-36Acid, C_18-36Acid diol ester, C_20-22Alkyl phosphate ester, C_20-22Alkanol polyether-30, C_20-40Alcohol mixture, C_20-40Alkanol polyether-3, C_20-40Alkanol polyether-10, C_20-40Alkanopolyether-24, C_20-40Alkanopolyether-40, C_22-24Alkanopolyether-33, C_29-70Acid, C_30-38Olefin/isopropyl maleate/MA copolymer, C_30-50Alkanol polyether-3, C_30-50Alkanol polyether-10, C_30-50Alkanopolyether-40, C_40-60Acid, C_40-60Alcohol mixture, C_40-60Alkanol polyether-3, C_40-60Alkanol polyether-10, C_6-10Alkanolpolyether-4-phosphate, C_6-8Alkyl radical C_3-6Alkyl glucoside dimethylsiloxane C_9-11Alkanopolyether-4, C_9-11Alkanol polyether-6, C_9-11Alkanopolyether-8, C_9-11Alkanol polyether-3, C_9-15Alkyl phosphate ester, C_9-15Alkanopolyether-8, C_9-16Alkane/cycloalkane, stearoyl lactyl calcium lactate, candelilla wax/jojoba/rice bran polyglycerol-3 ester, and hydrolyzed CandidaSophorolipid, decyl/lauryl wheat bran/straw glycoside, octanol polyether-4 carboxylic acid, octanol polyether-5, octanol polyether-6 carboxylic acid, octanol polyether-9 carboxylic acid, caprylic/capric glyceride polyglycerol-10 ester, caprylic/capric triglyceride PEG-4 ester, caprylic/capric/succinic triglyceride, octyl dimethyl siloxane ethoxy glucoside, octyl/decyl wheat bran/straw glycoside, octyl/decyl xyloside, PEG-8 ester of balsam, Pycnantokite, hydrogenated castor oil, white beeswax, ceteareth-2, ceteareth-3, ceteareth-4, ceteareth-5, ceteareth-6, ceteth-6, Ceteareth-7, ceteareth-8, isocetyl-ceteareth-8 stearate, ceteareth-9, ceteareth-10, ceteareth-11, ceteareth-12, ceteareth-13, ceteareth-14, ceteareth-15, ceteareth-16, ceteareth-17, ceteareth-18, ceteareth-20, ceteareth-22, ceteareth-23, ceteareth-24, ceteareth-25, ceteareth-27, ceteareth-28, ceteareth-29, Ceteareth-30, ceteareth-33, ceteareth-34, ceteareth-50, ceteareth-60, ceteareth-6 olivetoleate, ceteareth-60 myristyl glycol, cetearyl glucoside, cetearyl palmitate, cetearylmaltoside, ceteth-1, ceteth-2, ceteth-3, ceteth-4, ceteth-5, isocetyleth-5, ceteth-6, ceteth-7, isocetyleth-7, ceteth-8 phosphate, ceteth-10, ceteth-8, Isocetyl polyether-10, isocetyl polyether-10 stearate, ceteth-12, isocetyl polyether-12, ceteth-13, ceteth-14, ceteth-15, isocetyl polyether-15, ceteth-16, ceteth-17, ceteth-18, ceteth-20, isocetyl polyether poly (ether-s-isocetyl)Ether-20, ceteth-23, ceteth-24, ceteth-25, isocetyl-25, ceteth-30, isocetyl-30, ceteth-2, ceteth-4, ceteth-5, ceteth-6, ceteth-10, ceteth-11, ceteth-15, ceteth-18, ceteth-20, ceteth-22, cetyl glyceryl ether/glycerol copolymer, cetyl PEG-8 dimethicone, cetyl PEG/PPG-10/1 dimethicone, cetyl PEG/PPG-15/15 butyl ether dimethicone, ceteth-5, ceteth-6, ceteth-10, ceteth-11, ceteth-15, ceteth-18, ceteth-20, ceteth-22, cetyl glyceryl ether/glycerin copolymer, cetyl PEG-8 dimethicone, cetyl PEG/PPG-10/1 dimethicone, cetyl PEG/PPG-15/15 butyl ether dimethicone, Cetyl PEG/PPG-7/3 dimethyl siloxane, cetyl phosphate, anhydrous cetyl pyridinium chloride, shark liver stearate, chitosan lauramide hydroxypropyl trimethyl ammonium chloride, chitosan PCA palmitamide succinamide, chitosan stearamide hydroxypropyl trimethyl ammonium chloride, cholesterol, cholesteryl C16-18 alkenyl succinate, cholesteryl polyether-5, cholesteryl polyether-10, cholesteryl polyether-15, cholesteryl polyether-20, cholesteryl polyether-24, cholesteryl polyether-30, cocamide DIPA, cocoyl amine, cocoyl polyether-3, cocoyl polyether-5, cocoyl polyether-6, cocoyl polyether-7 carboxylic acid, cocoyl polyether-8, cocoyl polyether-10, Cocoeth-20, cocoeth-25, cocooleate estolide, coco/sunflower amidopropyl betaine, cocoglyceride, cocoglucoside hydroxypropyltrimonium chloride, cocoglyceride, coconut acid, hydrogenated coconut oil PEG-10 ester, coconut oil polyglycerol-6 ester, coconut oil PPG-2-PEG-6 ester, cocoyl ethyl glucoside, coffee seed oil PEG-8 ester, coffee seed oil polyglycerol-6 ester, corn oil glyceryl polyether-8 ester, acetylated hydrogenated cottonseed glyceride, camelina sativa seed oil phytosterol ester, decyl alcohol polyether-3, decyl alcohol polyether-4, isodecyl alcohol polyether-4, decyl alcohol polyether-4 phosphate, decyl alcohol polyether-5, isodecyl alcohol polyether-5, decyl alcohol polyether-6 ester, Isodecyl polyether-6, decyl polyether-6 phosphate, decyl polyether-7, decyl polyether-8, decyl polyether-9, decyl polyether-10, isodecyl polyether-2 cocoate, decyl tetradecyl polyether-5, decyl tetradecyl polyether-15, decyl tetradecyl polyether-20, decyl tetradecyl polyether-25, decyl tetradecyl polyether-30, decyl polyether-5, decyl polyether-2, decyl polyether-5, decyl polyether-15, decyl polyether-20, decyl polyether-25, decyl polyether-30, or mixtures thereof,Decyl tetradecanol polyether-10, di-C_12-15Alkanopolyether-2 phosphate, di-C_12-15Alkanopolyether-4 phosphate, di-C_12-15Alkanopolyether-6 phosphate, di-C_12-15Alkanopolyether-8 phosphate, di-C_12-15Alkyl polyether-10 phosphate, dibehenyl/di-arachidyl dimethyl ammonium chloride, dibehenyl dimethyl ammonium methosulfate, dibutoxymethane, didecyl/dioctyl dimethyl ammonium chloride, dicetyl stearyl polyether-10 phosphate, dicocoyl dimethylamine dilinoleate, didodecyl butane tetracarboxylate, diethylaminoethyl cocoate, diethylaminoethyl PEG-5 laurate, diethylene glycol diisononanoate, digalactosyl glycerol (linoleic/palmitic/oleic) ester, diglycerol/dilinoleic/hydroxystearic acid copolymer, diglyceryl sorbitan tetraethylhexanoate, dihydrocholesterol polyether-15, dihydrocholesterol polyether-20, dihydrocholesterol polyether-30, dihydrolanosterol, dihydroxyethyl tallow amine oxide, and mixtures thereof, Dilauryl polyether-4 phosphate, dilauryl polyether-7 citrate, dilauryl polyether-10 phosphate, hydrogenated dimer dilinolein polyether-20, hydrogenated dimer dilinolein polyether-30, hydrogenated dimer dilinolein polyether-40, hydrogenated dimer dilinolein polyether-80, hydrogenated dimer dilinolein polyether-60, dimethicone PEG-7 phosphate, dimethicone PEG-7 undecenoate, dimethicone PEG-8 avocado acid ester, dimethicone PEG-10 phosphate, dimethicone PEG-15 acetate, dimethicone PEG/PPG-12/4 phosphate, dimethicone PEG/PPG-7/4 phosphate, dimethicone/PEG-10 cross-linked polymer, dimethicone, Dimethicone/polyglyceryl-3 crosspolymer, dimethoxysilylethylenediaminopropyldimethicone, dimethyloctynediol, dimethylsoyamine, dimethylstearylamine, dimethyltallowamine, dimyristyl phosphate, dinonylphenol polyether-4 phosphate, dinonylphenol polyether-9 citrate, dioctyldidodecylstearyl glutamate, dioleoylpolyether-8 phosphate, dipentaerythritol hexaheptanoate/hexacaprylate/hexadecanoate, dipentaerythritol hexahydroxystearate, babassu oleoylamido MEA-disodium sulfosuccinate, whaleDisodium cerylphenyl ether disulfonate, disodium cocoeth-3 sulfosuccinate, disodium cocoglucoside citrate, disodium cocoglucoside sulfosuccinate, disodium decylphenyl ether disulfonate, disodium laureth-7 citrate, disodium lauroampholauroyl sarcosinate, disodium oleyl phosphate, disodium PEG-8 glyceryl caprylate/caprate, PEG-8 ricinoleic acid succinate diacid, disodium sitosterol polyether-14 sulfosuccinate, distearoylaminopropylmethylamine, dodecylhexadecyltrimethylammonium chloride, dodecylphenol polyether-13, ethylhydroxyethylcellulose, ethylenedihydrotallowamine, hydrolyzed ethylene/MA copolymer, long chain ester of cocoyl oleic acid, ethylhexyl linoleate stearate, disodium laureth-3 sulfosuccinate, disodium laureth-13, disodium laureth-8 glyceryl caprylate/caprate, disodium laureth-8, disodium laureth-14 sulfosuccinate, distearoylmethylamine, dodecylcetyltrimethylammonium chloride, dodecylphenol polyether-13, ethylhydroxyethylcellulose, ethylenedihydrotallowamine, hydrolyzed ethylene/MA copolymer, long chain ester of cocoyl oleate, ethylhexyl linoleate stearate, ethylhexyloxy stearate, sodium lauryl oleate, sodium lauryl sulfate, sodium lauryl sulfate, sodium lauryl sulfate, sodium lauryl sulfate, sodium lauryl sulfate, sodium, ethylhexyl glyceryl behenate, ethylhexyl glyceryl palmitate, C2-8 alkyldimethylsiloxane, perfluorononyl ethylcarboxydecyl PEG-10 dimethylsiloxane, fusel wheat bran/straw glycoside, glyceryl polyether-5 cocoate, glyceryl polyether-5 lactate, glyceryl polyether-6 laurate, glyceryl polyether-8 hydroxystearate, glyceryl polyether-20 stearate, glyceryl polyether-17 cocoate, glyceryl polyether-17 tallowate, glyceryl polyether-25 PCA isostearate, glyceryl arachidate, glyceryl behenate/eicosanoate, glyceryl decyl ether, glyceryl caprylate/capric glyceride, citric acid/lactic acid/linoleic acid/oleic glyceride, citric acid/lactic acid/oleic glyceride, glyceryl oleate, glyceryl monostearate, glyceryl stearate, glyceryl monostearate, glyceryl stearate, or, Cocoglyceride, dilaurate, dipalmitate, erucic acid glyceride, glycerol glycyrrhetinate, glycerol hydrogenated rapeseed oleate, glycerol hydroxystearate, isopalmitate, isostearate mixture, isotridecanoic acid/stearic acid/adipate, laurate, 1-laurate, laurate SE, glyceryl lauryl ether, linoleate, (S) -linoleate, glyceryl montanate, glyceryl myristate, glyceryl oleate citrate, oleate SE, glyceryl oleate/elaeate, glyceryl palmitate lactate, glyceryl palmitate, pentadecanoate, glyceryl ricinoleate SE, sesquialterGlyceryl oleate, glyceryl stearate citrate, glyceryl stearate lactate, glyceryl stearate SE, glyceryl stearate/maleate, glyceryl tallowate, glyceryl undecylenate, glyceryl/sorbitol oleate/hydroxystearate, glycol cetearate, glycol ethylhexanoate, hexaceryl glycol isostearate, 2-hexyldecanoic acid, hexyldecylpolyether-2, hexyldecylpolyether-20, hydroxycetyl isostearate, hydroxycetyl phosphate, hydroxyethyldiethylammonium polyisobutylethylaminosuccinate, hydroxypropyl cocoate PEG-8 dimethylsiloxane, hydroxystearyl alcohol, hydroxystearyl glucoside, hydroxysuccinimidyl C10-40 isoalkanoate, lanolin-4 phosphate, lanolin-5, Lanolin alcohol polyether-10, lanolin alcohol polyether-10 acetate, lanolin alcohol polyether-16, hydrogenated lanolin alcohol polyether-20, lanolin alcohol polyether-25, hydrogenated lanolin alcohol polyether-25, lanolin alcohol polyether-50, lanolin alcohol polyether-75, lard, hydrogenated lard, lauryl dimethyl chloro propyl ammonium chloride, lauryl dimethyl hydroxypropyl coco glucoside ammonium chloride, lauryl dimethyl hydroxypropyl decyl glucoside ammonium chloride, lauryl dimethyl hydroxypropyl lauryl glucoside ammonium chloride, lauryl alcohol polyether-1, lauryl alcohol polyether-2, lauryl alcohol polyether-3, isolauryl alcohol polyether-3, lauryl alcohol polyether-3 carboxylic acid, lauryl alcohol polyether-4 phosphate, isolauryl alcohol polyether-4 phosphate, lauryl alcohol polyether-4 phosphate, hydrogenated lanolin alcohol polyether-16, hydrogenated lanolin alcohol polyether-20, lanolin alcohol polyether-25, hydrogenated lanolin alcohol polyether-25, lanolin alcohol polyether-50, lanolin alcohol polyether-75, lard, hydrogenated lard, lauryl alcohol glyceride, lauryl alcohol dimethyl chloro propyl ammonium chloride, lauryl alcohol glucoside ammonium chloride, lauryl alcohol polyether-1, lauryl alcohol polyether-2, lauryl alcohol polyether-3, lauryl alcohol polyether-4 phosphate, lauryl alcohol-4, and lauryl alcohol polyether-4, Laureth-5, laureth-5-butyl ether, laureth-5-carboxylic acid, laureth-6, isolaureth-6, laureth-7-phosphate, laureth-8, laureth-9, laureth-10, isolaureth-10, laureth-11, laureth-12, laureth-13, laureth-14, laureth-15, laureth-16, laureth-20, laureth-23, laureth-25, laureth-30, laureth-13 PG-hydroxyethyl cellulose, laureth-13-dipropylene glycol, lauroyl ethyl glucoside, Lauryl dimethyl silicone PEG-10 phosphate, lauryl dimethyl silicone PEG-15 cross-linked polymer, lauryl isoamyl-PEG/PPG-18/18 methylSiloxane, lauryl PEG-10 tris (trimethylsiloxy) silylethyldimethylsiloxane, lauryl PEG-8PPG-8 dimethylsiloxane, lauryl phosphate, lauryl polyglyceryl-6 cetostearyl glycol ether, lauryl sucrose, lauryl/myristyl wheat bran/straw glycoside, lecithin, hydroxylated lecithin, linseed acid, linseed oil polyglyceryl-4 ester, lithium myristate, lysolecithin, hydrogenated lysophosphatidylcholine, lysophosphatidylglycerol, cocoeth sulfate magnesium, monomannitol laurate, monomannitol oleate, mannose erythritol esters, wool palm kernel oil PEG-8 ester, wool palm kernel oil polyglyceryl-6 ester, laureth-6 carboxylate MEA salt, PPG-8-steareth-7 carboxylate MEA salt, PPG-8-stearyl polyether-7 carboxylate salt, Hydrogenated menhaden fatty acid, methoxy PEG-17/dodecanediol copolymer, bis-methoxy PEG-40 polyepsilon caprolactone, methoxy PEG/PPG-25/4 dimethicone, methyl gluceth-10, methyl glucose isostearate, methyl glucose laurate, methyl glucose sesquicaprylate/sesquicaprate, methyl glucose sesquicocoate, methyl glucose sesquiisostearate, methyl glucose sesquilaurate, methyl glucose sesquioleate, methyl glucose sesquistearate, methyl isostearate, methylsilanol PEG-7 glyceryl cocoate, methylsilanol tri-PEG-8 glyceryl cocoate, methyl glucose dioleate/hydroxystearate, mink amidopropyl dimethylamine, myristyl polyether-2, Myristyl polyether-3, myristyl polyether-4, myristyl polyether-5, isomyristyl polyether-9, myristyl polyether-10, isomyristyl polyether-3, myristoyl ethyl glucoside, myristoyl lactic acid, myristyl dimethyl hydroxypropyl cocoyl glucoside ammonium chloride, nonyl phenyl polyether-5, oat oil amidopropyl dimethylamine, octadecenedioic acid, octyl decyl oleate, octyl decyl phosphate, octyl dodecyl polyether-2, octyl dodecyl polyether-5, octyl dodecyl polyether-10, octyl dodecyl polyether-16, octyl dodecyl polyether-20, octyl dodecyl polyether-25, octyl dodecyl glucoside, octyl dodecyl xyloside, oleamide DIPA, (Z) -oleic acid, isopropyl alcohol polyether-5, isopropyl alcohol-3, isopropyl alcohol polyether-3, myristyl alcohol polyether-5, myristyl lactic acid, myristyl dimethyl hydroxypropyl cocoyl glucoside ammonium chloride, nonyl phenyl polyether-5, oat oil amidopropyl dimethylamine, octadecyl diacid, octyl decyl oleate, octyl decyl alcohol phosphate, octyl dodecyl alcohol polyether-2, octyl dodecyl alcohol polyether-5, octyl dodecyl alcohol polyether-16, octyl dodecyl alcohol polyether-20, octyl dodecyl alcohol polyether-25, octyl dodecyl alcohol glucoside, octyl dodecyl alcohol-D, oleyl alcohol, oleic acid, isopropyl alcohol-4, isopropyl alcohol-9, and isopropyl alcohol-4, and isopropyl alcohol, Oleoyl ethyl glucoside, oleyl polyether-10. Oleyl polyether-11, oleyl polyether-12, oleyl polyether-15, oleyl polyether-16, oleyl polyether-45, oleyl polyether-2 phosphate, oleyl polyether-20 phosphate, oleyl polyether-3, oleyl polyether-30, oleyl polyether-35, oleyl polyether-4, oleyl polyether-40, oleyl polyether-5, oleyl polyether-6, oleyl polyether-7, oleyl polyether-8, oleyl polyether-82, oleyl polyether-9, oleyl phosphate, olive amidopropyl trimethyl ammonium chloride, olive glyceride, olive oil glyceryl polyether-8, olive oil PEG-7, olive oil PEG-8, olive oil PEG-10, olive oil PEG/PPG-3/1, ester, Olive oil polyglyceryl-6 ester, palmitic acid, palm glyceride, hydrogenated palm glyceride, palm kernel acid, palm kernel alcohol, palm kernel glyceride, acetylated palm kernel glyceride, palm kernel oil polyglyceryl-4 ester, palm kernel amide MIPA, hydrogenated palm oil, palm oil polyether-8 ester, palm oil PEG-8 ester, palm oil polyglyceryl-3 ester, palm oil polyglyceryl-4 ester, palm oil polyglyceryl-6 ester, hydrogenated palm/palm kernel glyceride, hydrogenated palm/palm kernel oil PEG-6 ester, palmitamide DEA, palmitamide MEA, palmitamide MIPA, palm oil polyether-2 phosphate, palmitamide butylguanidine acetate, palmitic acid, palmitoylethyltrimethyl ammonium methosulfate, Palmitoyl inulin, PEG-8 ester of Cochloae oil, polyglycerol-6 ester of Cochloae oil, arachidic ester, arachidic amide MIPA, PEG-2 octylamine, PEG-2 cocamide, PEG-2 cocoamine, PEG-2 diisostearate, PEG-2 dioleate, PEG-2 hydrogenated castor oil, PEG-2 hydrogenated tallow amine, PEG-2 isostearate, PEG-2 lauramide, PEG-2 SE oleate, PEG-2 olive glyceride, PEG-2 sorbitan isostearate, PEG-2 sorbitan trioleate, PEG-2 soya amine, PEG-2 stearate SE, PEG-2 sunflower glyceride, PEG-2 tallow amide DEA, PEG-3 butylene glycol laurate, PEG-3 castor oil, PEG-2 hydrogenated tallow fatty acid, PEG-2 hydrogenated tallow amine, PEG-2 isostearate, PEG-2 lauryl sulfate, PEG-2 sunflower glyceride, PEG-2 tallow amide DEA, PEG-3 butylene glycol laurate, PEG-3 castor oil, PEG-6 ester, and mixtures thereof, PEG-3 Cocamide DEA, PEG-3 Cocoimide, PEG-3 dicaprylate/caprate, PEG-3 diisostearate, PEG-3 distearate, PEG-3 cocoglyceride, PEG-3 isostearyl, PEG-3 triisostearate, PEG-3 triolein, PEG-3 tristearate, PEG-3 cocoglyceride, PEG-3 cocoamide DEA, PEG-3 cocoamide/caprate, PEG-3 diisostearate, PEG-3 cocoglyceride, PEG-3 cocoamide DEA, PEG-3 cocoamide/caprate, PEG-3 dicaprylate, PEG-3 diisostearate, PEG-caprate, PEG-3 diisostearate, PEG-stearate, PEG-3 cocoglyceride, PEG-3 cocoate, PEG-3 cocoamide DEA, PEG-3 cocoamide, PEG-glyceryl sebacate, PEG-3 cocoate, PEG-3 isostearate, PEG-3 glyceryl monostearate, PEG-3, PEG-glyceryl stearate, PEG-3-glyceryl stearate, PEG-3-glyceryl stearate, and PEG-glyceryl stearate, PEG-3-glyceryl stearate, and PEG-glyceryl stearate,PEG-3 isostearate, PEG-3 lanolate, PEG-3 lauramide, PEG-3 oleamide, PEG-3 oleate, PEG-3 sorbitan stearate, PEG-3 sorbitan tristearate, PEG-3 stearate, PEG-3 tallowamine, PEG-3/PPG-2 glyceryl/sorbitol hydroxystearate/isostearate, PEG-4 caprylic/capric glyceride, PEG-4 castor oil, PEG-4 cocamide, PEG-4 cocoamine, PEG-4 diisostearate, PEG-4 ethylhexanoate, PEG-4 glyceryl tristearate, PEG-4 isostearate, PEG-4 lanolate, PEG-4 lauramide, PEG-3 oleamide, PEG-3 oleate, PEG-3 sorbitan oleate, PEG-4 caprylic/capric glyceride, PEG-4 glyceryl monostearate, PEG-4 isostearate, PEG-4 lanolin acid ester, PEG-4 laurate, PEG-4 lauramide, PEG-amide, PEG-3 oleyl amide, PEG-3 tallow amine, PEG-3 oleate, PEG-3 sorbitan oleate, PEG-4 glyceryl stearate, PEG-4 glyceryl stearate, and PEG-4 glyceryl stearate, PEG-4 oleate, PEG-4 polyglycerin-2 distearate, PEG-4 polyglycerin-2 stearate, PEG-4 sorbitan triisostearate, PEG-4 stearate, PEG-4 trimethylolpropane distearate, PEG-5 castor oil, PEG-5 cocoamine, PEG-5 glyceryl isostearate, PEG-5 glyceryl oleate, PEG-5 glyceryl stearate, PEG-5 glyceryl triisostearate, PEG-5 glyceryl trioleate, PEG-5 glyceryl tristearate, PEG-5 hydrogenated castor oil isostearate, PEG-5 hydrogenated castor oil triisostearate, PEG-5 hydrogenated corn glyceride, PEG-4 glyceryl distearate, PEG-4 sorbitan stearate, PEG-4 glyceryl isostearate, PEG-5 glyceryl isostearate, PEG-4 glyceryl triisostearate, PEG-4 glyceryl isostearate, PEG-4 glyceryl distearate, PEG-4 trimethylolpropane distearate, PEG-5 isostearate, PEG-5 glyceryl isostearate, and PEG-5 glyceryl isostearate, PEG-5 hydrogenated lanolin, PEG-5 lanolate, PEG-5 lanolin, PEG-5 lanolate amide, PEG-5 lauramide, PEG-5 oleamide dioleate, PEG-5 oleylamine, PEG-5 oleate, PEG-5 phytosterol, PEG-5 brassicasterol, PEG-5 soyasterol, PEG-5 soyamine, PEG-5 stearylamine, PEG-5 stearate, PEG-5 tallowate, PEG-5 tridecyl citrate, PEG-5 trimethylolpropane trimyristate, PEG-5 glyceryl camelleate, PEG-6 amygdalin, PEG-6 beeswax, PEG-6 butanediol laurate, PEG-6 caprylate/caprate, PEG-6 diisostearate, PEG-6 dioleate, PEG-6 glyceryl caprate, PEG-6 glyceryl isostearate, PEG-6 glyceryl tristearate, PEG-6 hydrogenated castor oil, PEG-6 hydrogenated palm/palm kernel glyceride, PEG-6 hydrogenated palmitamide, PEG-6 isopalmitate, PEG-6 isostearate, PEG-6 lanolin acid ester, PEG-6 lauramide, PEG-6 laurate/tartrate, PEG-6 methylsiloxane acetate, PEG-6 methylether dimethylsiloxane, PEG-6 oleylamine, PEG-6 oleate, PEG-6 olive glyceride, PEG-6 propylene glycol caprylate/caprate, PEG-6 sorbitan oleate, PEG-6 sorbitan stearate, PEG-6 stearylguanidine, PEG-7 caprylic/capric glyceride, PEG-7 cocamide, PEG-7 cocoyl glyceride, PEG-7 glyceryl soya oleate, PEG-7 hydrogenated castor oil, PEG-7 lanolin ester, PEG-7 methyl ether dimethyl siloxane, PEG-7 oleate, PEG-7 olive glyceride, PEG-7 ricinoleic acid amide, PEG-7 sunflower glyceride, PEG-7 tallow amine, PEG-7 trimethylolpropane coconut ether, PEG-8 avocado ester, PEG-8 behenate ester, and mixtures thereof, PEG-8C12-18 alkyl ester, PEG-8 caprate, PEG-8 caprylate/caprate, PEG-8 caprylic/capric glyceride, PEG-8 castor oil, PEG-8 cocoamine, PEG-8 cranberry ester, PEG-8 di/tri-ricinoleate, PEG-8 di-cocoate, PEG-8 di-isostearate, PEG-8 dodecenyl succinate, PEG-8 glyceryl isostearate, PEG-8 hydrogenated castor oil, PEG-8 hydrogenated fish oil glyceride, PEG-8 isostearate, PEG-8 lanolin acid ester, PEG-8 myristate, PEG-8 oleate, PEG-8PEG-4 dimethicone, PEG-8 raspberry ester, PEG-8 sesquilaurate, PEG-8 sesquioleate, PEG-8 soyamine, PEG-8 tallate, PEG-8 trisiloxane, PEG-8 undecylenate, PEG-9 avocado acid ester, PEG-9 boranate, PEG-9 butanediol laurate, PEG-9 butyl caprylate, PEG-9 castor oil, PEG-9 cocoyl glyceride, PEG-9 diethylmethylammonium chloride, PEG-9 glyceryl isostearate, PEG-9 grapeseed oil ester, PEG-9 isostearate, PEG-9 laurate, PEG-9 methylether dimethylsiloxane, PEG-9 octyldodecanoate, PEG-9 oleate, PEG-9 polydimethylsiloxyethyldimethylsiloxane, PEG-9 soyate, PEG-9 stearate, PEG-10 butanediol isostearate, PEG-8 undecanoate, PEG-10 castor oil, PEG-10 cocoamine, PEG-10 cocoate, PEG-10 dioleate, PEG-10 diisostearin, PEG-10 isostearyl glyceride, PEG-10 oleic glyceride, PEG-10 stearin, PEG-10 triisostearin, PEG-10 triolein, PEG-10 tristearin, PEG-10 hydrogenated castor oil isostearate, PEG-10 hydrogenated castor oil triisostearate,PEG-10 hydrogenated lanolin, PEG-10 hydrogenated tallow amine, PEG-10 lauryl sulfide, PEG-10 isostearate, PEG-10 lanolin acid ester, PEG-10 lanolin, PEG-10 laurate, PEG-10 methyl ether dimethyl siloxane, PEG-10 oleylamine, PEG-10 oleate, PEG-10 olive glyceride, PEG-10 phytosterol, PEG-10 campesterol, PEG-10 sorbitan laurate, PEG-10 soyasterol, PEG-10 soyamine, PEG-10 stearamide, PEG-10 stearate, PEG-10 sunflower glyceride, PEG-10 tallowate, PEG-10 tallow propylamine, PEG-10 camellia oleate, PEG-11 avocado glyceride, PEG-11 babassu glyceride, PEG-11 castor oil, PEG-11 cocamide, PEG-11 cocoglyceride, PEG-11 lauramide, PEG-11 methyl ether dimethicone, PEG-11 oleate, PEG-11 tallow amine, PEG-12 beeswax, PEG-12 cocoamine, PEG-12 diisostearate, PEG-12 dilaurate, PEG-12 dimethicone crosspolymer, PEG-12 dioleate, PEG-12 distearate, PEG-12 ditoluate, PEG-12 laurate, PEG-12 isostearate, PEG-12 lanolate, PEG-12 laurate, PEG-12 oleate, PEG-12 palm kernel glyceride, PEG-12 stearate, PEG-12 tallate, PEG-13 dihydroxyphenyl propane, PEG-11 lauryl ether, PEG-11 methyl ether dimethicone, PEG-11 oleate, PEG-12 glyceryl ether, PEG-12, and PEG-12 glyceryl ether, PEG-13 ethylhexanoate, PEG-13 hydrogenated tallow amide, PEG-13 sunflower glyceride, PEG-14 avocado glyceride, PEG-14 laurate, PEG-14 oleate, PEG-14 stearate, PEG-14 palmitate, PEG-15 butylene glycol diisostearate, PEG-15 castor oil, PEG-15 cocoamine oleate/phosphate, PEG-15 cocoamine, PEG-15 cocopolyamine, PEG-15 diisostearate, PEG-15 glyceryl laurate, PEG-15 glyceryl oleate, PEG-15 glyceryl ricinoleate, PEG-15 glyceryl stearate, PEG-15 triisostearate, PEG-15 glyceryl trioleate, PEG-15 glyceryl tristearate, PEG-14 glyceryl monostearate, PEG-14 hydrogenated tallow amide, PEG-13 sunflower glyceride, PEG-14 avocado glyceride, PEG-14 laurate, PEG-15 cocoamine oleate/phosphate, PEG-15 cocoamine stearate, PEG-15 glyceryl laurate, PEG-15 glyceryl oleate, PEG-15 glyceryl monostearate, PEG-15 glyceryl stearate, PEG-15 glyceryl triisostearate, PEG-15 glyceryl stearate, PEG-15 glyceryl monostearate, and PEG-15 glyceryl stearate, PEG-15 hydrogenated castor oil isostearate, PEG-15 hydrogenated castor oil triisostearate, PEG-15 hydrogenated lanolin, PEG-15 hydrogenated tallow amine, PEG-15 hydroxystearate, PEG-15 jojoba acid, PEG-15 jojoba alcohol, PEG-15 lanolin acid ester, bis-PEG-15 methyl ether dimethyl siloxane, PEG-15 oleylamine, PEG-15 oleate, PEG-15 phytosterol, PEG-15 soybean isostearateAmine, PEG-15 stearamide, PEG-15 stearylamine, PEG-15 stearate, PEG-15 tallowate, PEG-15 tallowaminopropylamine, PEG-16 castor oil, PEG-16 cetyl/oleyl/lanolin alcohol ether, PEG-16 dilaurate, PEG-16 hydrogenated castor oil, PEG-16 macadamia nut glycerides, PEG-16 oleate, PEG-16 soyasterol, PEG-16 tallowate, PEG-18 castor oil dioleate, PEG-18 glyceryl oleate/cocoate, PEG-18 palmitin, PEG-18 stearate, PEG-20 amygdalin, PEG-20 beeswax, PEG-20 castor oil, PEG-20 cocamide, PEG-20 cocoamine, PEG-20 zein, PEG-20 glyceryl esters, PEG-20 dioleate, PEG-20 evening primrose glyceride, PEG-20 diisostearic glyceride, PEG-20 triisostearic glyceride, PEG-20 triolein, PEG-20 tristearin, PEG-20 hexadecenyl succinate, PEG-20 hydrogenated castor oil isostearate, PEG-20 hydrogenated castor oil PCA isostearate, PEG-20 hydrogenated dimer dilinoleate, PEG-20 hydrogenated palm glyceride, PEG-20 isostearate, PEG-20 lanolate, PEG-20 lanolin, PEG-20 mannide laurate, PEG-20 methyl glucose sesquicaprylate/sesquidecanoate, PEG-20 methyl glucose sesquilaurate, PEG-20 myristate, PEG-20 isostearate, PEG-20 glyceryl stearate, PEG-20 glyceryl stearate, PEG-methyl glyceryl stearate, PEG-20 glyceryl stearate, PEG-methyl glyceryl stearate, PEG-20, PEG-methyl glyceryl stearate, and PEG-methyl glyceryl stearate, PEG-methyl ester, PEG-methyl glyceryl stearate, and PEG-methyl glyceryl stearate, PEG-methyl glyceryl stearate, PEG-20 oleylamine, PEG-20 oleate, PEG-20 sorbitan isostearate, PEG-20 sorbitan oleate, PEG-20 sorbitan triisostearate, PEG-20 soyasterol, PEG-20 tallate, PEG-20 glyceryl oleate, PEG-20-PPG-10 glyceryl stearate, PEG-23 cetyl eicosanoate, PEG-23 octyldodecanoate, PEG-23 oleate, PEG-23 stearate, PEG-24 hydrogenated lanolin, PEG-24 lanolin, PEG-25 butylene glycol isostearate, PEG-25 glyceryl trioleate, PEG-25 hydrogenated castor oil, PEG-25 glyceryl moringate, PEG-25 plant material, PEG-20 glyceryl isostearate, PEG-20 sorbitan oleate, PEG-20 glyceryl triisostearate, PEG-23 glyceryl laurate, PEG-23 oleate, PEG-24 hydrogenated lanolin, PEG-25 glyceryl isostearate, PEG-25 glyceryl monostearate, PEG-25 plant material, PEG-25 hydrogenated castor oil, PEG-25 glyceryl monostearate, PEG-25, PEG-glyceryl monostearate, and PEG-25, PEG-25 propylene glycol stearate, PEG-25 soyasterol, PEG-25 stearate, PEG-26 castor oil, PEG-26 jojoba acid, PEG-26 jojoba alcohol, PEG-27 lanolin, PEG-30 castor oil, PEG-30 glyceryl diisostearate, PEG-30 glyceryl triisostearate, PEG-30 glyceryl trioleate, PEG-30 hydrogenated castor oil isostearateSesame oil PCA isostearate, PEG-30 hydrogenated castor oil triisostearate, PEG-30 hydrogenated dimer dilinoleate, PEG-30 hydrogenated lanolin, PEG-30 isostearate, PEG-30 lanolin, PEG-30 oleylamine, PEG-30 phytosterol, PEG-30 sorbitan tetraoleate, PEG-30 soyasterol, PEG-32 dioleate, PEG-32 methyl ether dimethicone, PEG-32 oleate, PEG-32 stearate, PEG-33 castor oil, PEG-35 almond glyceride, PEG-35 hydrogenated castor oil, PEG-35 lanolin, PEG-35 soyaglyceride, PEG-35 stearate, PEG-36 castor oil, PEG-36 oleate, PEG-36 stearate, PEG-40 distearate, PEG-30 hydrogenated dimer dilinoleate, PEG-32 glyceryl tetraoleate, PEG-32 oleate, PEG-32 glyceryl tetraoleate, PEG-35 glyceryl tetraoleate, PEG-36 oleate, PEG-36 stearate, PEG-40 distearate, PEG-30 glyceryl tetraoleate, PEG-30 hydrogenated castor oil, PEG-30 hydrogenated dimer fatty acid, PEG-32 oleate, PEG-32 fatty acid, PEG-fatty acid, and PEG-32 fatty acid, PEG-40 glyceryl isostearate, PEG-40 glyceryl stearate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl trioleate, PEG-40 hydrogenated castor oil isostearate, PEG-40 hydrogenated castor oil triisostearate, PEG-40 hydrogenated dimer dilinoleate, PEG-40 hydrogenated lanolin, PEG-40 isostearate, PEG-40 jojoba acid, PEG-40 jojoba alcohol, PEG-40 lanolin, PEG-40 olive glyceride, PEG-40 ricinoleic acid amide, PEG-40 sorbitan diisostearate, PEG-40 sorbitan laurate, PEG-40 sorbitan oleate, PEG-40 sorbitan monoisostearate, PEG-40 sorbitan isostearate, PEG-40 sorbitan monostearate, PEG-40 sorbitan tetraoleate, PEG-40 soyasterol, PEG-42 babassu glyceride, PEG-42 mushroom glyceride, PEG-44 castor oil, PEG-45 hydrogenated castor oil, PEG-45 palm kernel glyceride, PEG-45 safflower glyceride, PEG-45 stearate, PEG-50 castor oil, PEG-50 isostearic acid glyceride, PEG-50 triisostearic acid glyceride, PEG-50 triolein, PEG-50 hydrogenated castor oil isostearate, PEG-50 hydrogenated castor oil succinate, PEG-50 hydrogenated castor oil triisostearate, PEG-50 lanolin, PEG-50 stearamide, PEG-50 stearylamine, PEG-54 castor oil, PEG-54 hydrogenated castor oil, PEG-55 hydrogenated castor oil, PEG-55 lanolin, lanolin, PEG-55 stearate, PEG-58 hydrogenated castor oil isostearate, PEG-60 castor oil isostearate, PEG-60 corn glyceride, PEG-60 evening primrose glyceride, PEG-60 diisostearic glyceride, PEG-60 stearin, PEG-60 triisostearic glyceride, PEG-60 trioleinGlyceride, PEG-60 hydrogenated castor oil triisostearate, PEG-60 hydrogenated dimer dilinoleate, PEG-60 lanolin, PEG-60 glyceryl drumstick, PEG-60 pink passion fruit seed glyceride, PEG-60 tallowseed glyceride, PEG-60 sorbitan tetraoleate, PEG-60 sorbitan tetrastearate, PEG-60 glyceryl cameleate, PEG-65 butanediol isostearate, PEG-65 hydrogenated castor oil, PEG-66 trihydroxystearin, PEG-70 hydrogenated lanolin, PEG-70 mango glyceride, PEG-75 beta-sitosterol, PEG-75 castor oil, PEG-75 coco glyceride, PEG-75 dark sea two-segment camelina oil, PEG-75 dioleate, PEG-75 lanolin, PEG-75 lanolin wax, PEG-75 white mango flower oil, PEG-75 propylene glycol stearate, PEG-75 tallowglyceride, PEG-75 buckeye diglyceride, PEG-75 soyabean glyceride, PEG-80 castor oil, PEG-80 hydrogenated dimer dilinoleate, PEG-80 hydrogenated palmitic glyceride, PEG-80 methyl glucose laurate, PEG-80 sorbitan palmitate, PEG-82 glyceryl tallowate, PEG-85 lanolin, PEG-90/poly epsilon-caprolactone, PEG-100 castor oil, PEG-100 hydrogenated castor oil, PEG-100 lanolin, PEG-114 polylactic acid, PEG-12 dioleate, PEG-12 palmylamine, PEG-120 distearate, PEG-120 methyl glucose dioleate, PEG-120 propylene glycol stearate, PEG-130 glyceryl tallowate, PEG-140 glyceryl tristearate, PEG-15 cocoylmethylammonium chloride, PEG-15 glyceryl isostearate, PEG-15 tallow polyamine, PEG-150 behenate, PEG-150 dilaurate, PEG-150 dioleate, PEG-150 lanolin, PEG-150 polyglyceryl-2 tristearate, PEG-160 sorbitan triisostearate, PEG-175 diisostearate, PEG-175 distearate, PEG-18 palmitate, PEG-190 distearate, PEG-192 amygderol, PEG-2 castor oil, PEG-2 cocoylmethylammonium chloride, PEG-2 diethylhexanoate, PEG-2 dilaurate, PEG-2 distearate, PEG-2 laurate SE, PEG-2 oleylamine, PEG-2 oleylmethylammonium chloride, PEG-2 ricinoleate, PEG-2 stearylmethylammonium chloride, PEG-20 cocamide MEA, PEG-20 dilaurate, PEG-20 distearate, PEG-20 laurin, PEG-20 oleate, PEG-2 glyceryl oleate, PEG-2 lauryl sulfate, PEG-2 laurin, PEG-2 lauryl sulfate, PEG-2 oleyl chloride, PEG-20 lauryl sulfate, PEG-2 oleyl chloride, PEG-20 lauryl sulfate, PEG-20, PEG-2 oleyl chloride, PEG-20 glyceryl sulfate, PEG-2 oleyl chloride, PEG-2, PEG-20, PEG-2 oleyl chloride, PEG-2 oleyl chloride, PEG-2, PEG-,PEG-20 glyceryl ricinoleate, PEG-20 glyceryl stearate, PEG-20 hydrogenated lanolin, PEG-20 laurate, PEG-20 methyl glucose distearate, PEG-20 methyl glucose sesquistearate, PEG-20 palmitate, PEG-20 phytosterol, PEG-20 sorbitan cocoate, PEG-20 stearate, PEG-20 tallowate, PEG-200 castor oil, PEG-200 glyceryl tallowate, PEG-200 hydrogenated castor oil, PEG-200 hydrogenated glyceryl palmitate, PEG-200 trihydroxystearin, PEG-22/dodecanediol copolymer, PEG-23 glyceryl laurate, PEG-23 olive oleate, PEG-25 castor oil, PEG-25 glyceryl oleate, PEG-25 glyceryl stearate, PEG-20 hydrogenated lanolin, PEG-20 glyceryl distearate, PEG-20 glyceryl stearate, PEG-20 glyceryl monostearate, PEG-200 glyceryl monostearate, PEG-20 glyceryl stearate, PEG-23 glyceryl stearate, PEG-25 glyceryl oleate, PEG-25 glyceryl stearate, PEG-20 glyceryl stearate, PEG-sodium stearate, and PEG-20 glyceryl stearate, PEG-28 glyceryl tallowate, PEG-29 castor oil, PEG-3 cocamide, PEG-3 dioleate, PEG-3 dipalmitate, PEG-30 dipolyhydroxystearate, PEG-30 cocoglyceride, PEG-30 glyceryl laurate, PEG-30 glyceryl oleate, PEG-30 glyceryl stearate, PEG-30 hydrogenated tallow amine, PEG-30 stearate, PEG-32 dilaurate, PEG-32 distearate, PEG-35 castor oil, PEG-4 cocoate, PEG-4 diheptanoate, PEG-4 dioleate, PEG-4 distearate, PEG-4 laurate, PEG-4 oleamide, PEG-4 olive oleate, PEG-40 castor oil, PEG-40 glyceryl cocoate, PEG-40 cocoate, PEG-40 hydrogenated castor oil, PEG-40 hydrogenated tallow amine, PEG-40 sorbitan lanolin fatty acid ester, PEG-40 sorbitan monooleate, PEG-40 stearate, PEG-5 cocamide, PEG-5 cocoate, PEG-5 ethylhexanoate, PEG-5 glyceryl sesquioleate, PEG-5 hydrogenated tallow amine, PEG-5 isononanoate, PEG-5 oleamide, PEG-5 sorbitan isostearate, PEG-5 tallow amide, PEG-50 hydrogenated tallow amine, PEG-50 tallow resin, PEG-50 stearate, PEG-50 tallow amide, PEG-6 caprylic/capric glycerides, PEG-6 dilaurate, PEG-6 distearate, PEG-6 isolauryl sulfide, PEG-40 sorbitan lanolin fatty acid ester, PEG-40 sorbitan monooleate, PEG-40 glyceryl monooleate, PEG-5 hydrogenated tallow amine, PEG-5 isononanoate, PEG-5 isononanoamide, PEG-5 oleyl acid, PEG-6 glyceryl monostearate, PEG-6 dilaurate, and lauryl sulfide, PEG-6 oleamide, PEG-6 palmitate, PEG-60 amygdalin, PEG-7 cocoglyceride, PEG-7 oleamide, PEG-7 olive oleate, PEG-7 ricinoleate, PEG-7 stearate, PEG-75 dilaurate, PEG-75 distearate, PEG-75 lanolin oil, PEG-75 sorbitan lanolate, PEG-78 cocoglyceride, PEG-8 beeswax, PEG-8 cocoate, PEG-8 dilaurateAcid esters, PEG-8 dioleate, PEG-8 distearate, PEG-8 ditoluate, PEG-8 glyceryl laurate, PEG-8 hydrogenated tallow amine, PEG-8 isolauryl sulfide, PEG-8 laurate, PEG-8 propylene glycol cocoate, PEG-8 stearate, PEG-8 tallow amide, PEG-80 glyceryl cocoate, PEG-80 glyceryl tallowate, PEG-9 cocoate, PEG-9 distearate, PEG-9 oleamide, PEG-9 olivate, PEG-9 stearamide carboxylic acid, PEG/poly (1, 2-butylene glycol) -52/32 dimethyl ether, PEG/PPG-2/16 copolymer, PEG/PPG-3/30 copolymer, PEG/PPG-5/21 copolymer, PEG/PPG-6/39 copolymer, PEG/PPG-6/67 copolymer, PEG/PPG-7/21 copolymer, PEG/PPG-7/22 copolymer, PEG/PPG-7/91 copolymer, PEG/PPG-8/30 copolymer, PEG/PPG-8/35 copolymer, PEG/PPG-10/2 copolymer, PEG/PPG-10/30 copolymer, PEG/PPG-10/47 copolymer, PEG/PPG-11/16 copolymer, PEG/PPG-11/21 copolymer, PEG/PPG-12/136 copolymer, PEG/PPG-12/23 copolymer, PEG/PPG-12/4 copolymer, PEG/PPG-12/9 copolymer, PEG/PPG-6/67 copolymer, PEG/PPG-3932 copolymer, PEG/PPG-3583 copolymer, PEG/PPG-12/9 copolymer, PEG/PPG-6/67 copolymer, PEG/PPG-7/21 copolymer, PEG/PPG-6/67 copolymer, PEG/PPG-10/30 copolymer, PEG/PPG-7/22 copolymer, PEG/PPG-3538 copolymer, PEG/PPG-10/30 copolymer, PEG/PPG-8/30 copolymer, PEG/PPG-10/30 copolymer, PEG/PPG-8/30 copolymer, PEG/PPG-10/30 copolymer, PEG/PPG-12/4 copolymer, PEG/PPG-11/16, PEG/PPG copolymer, PEG/PPG-11/16 copolymer, PEG/PPG-11/16, PEG/PPG copolymer, PEG/PPG-8/35 copolymer, PEG/PPG copolymer, PEG/PPG-10/30 copolymer, PEG/PPG-10/30 copolymer, PEG/PPG-11/16, PEG/PPG copolymer, PEG/PPG copolymer, PEG/, PEG/PPG-13/30 copolymer, PEG/PPG-13/67 copolymer, PEG/PPG-18/14 copolymer, PEG/PPG-18/163 copolymer, PEG/PPG-18/34 copolymer, PEG/PPG-18/51 copolymer, PEG/PPG-19/30 copolymer, PEG/PPG-20/54 copolymer, PEG/PPG-21/15 copolymer, PEG/PPG-21/39 copolymer, PEG/PPG-21/47 copolymer, PEG/PPG-21/67 copolymer, PEG/PPG-21/7 copolymer, PEG/PPG-22/39 copolymer, PEG/PPG-24/35 copolymer, PEG/PPG-30/160 copolymer, PEG/PPG-13/67 copolymer, PEG/PPG-3932 copolymer, PEG/PPG-3583 copolymer, PEG/PPG-30/160 copolymer, PEG/PPG-13/67 copolymer, PEG/PPG-18/14 copolymer, PEG/PPG-13/67 copolymer, PEG/PPG-21/15 copolymer, PEG/PPG-18/163 copolymer, PEG/PPG-3538 copolymer, PEG/PPG-21/15 copolymer, PEG/PPG-18/51 copolymer, PEG/PPG-21/15 copolymer, PEG/PPG-18/51 copolymer, PEG/PPG-21/15 copolymer, PEG/PPG-24/35 copolymer, PEG/PPG-21/47, PEG/PPG copolymer, PEG/PPG-21/47 copolymer, PEG/PPG-21/47, PEG/PPG copolymer, PEG/PPG-19/30 copolymer, PEG/PPG copolymer, PEG/PPG-21/15 copolymer, PEG/PPG-21/15 copolymer, PEG/PPG-21/47, PEG/PPG copolymer, PEG/PPG copolymer, PEG/, PEG/PPG-31/54 copolymer, PEG/PPG-38/54 copolymer, PEG/PPG-46/16 copolymer, PEG/PPG-52/35 copolymer, PEG/PPG-62/39 copolymer, PEG/PPG-97/39 copolymer, PEG/PPG-98/67 copolymer, PEG/PPG-10/2 di-ricinoleate, PEG/PPG-10/2 propyl heptyl ether, PEG/PPG-10/3 oleyl ether dimethicone, PEG/PPG-12/16 dimethicone, PEG/PPG-12/18 dimethicone, PEG/PPG-122/47 copolymer, PEG/PPG-128/54 copolymer, bis-PEG/PPG-14/14 dimethicone, PEG/PPG-14/2 propylheptyl ether, PEG/PPG-14/4 dimethyl siloxane, PEG/PPG-15/15 acetate dimethyl siloxane, PEG/PPG-15/15 allyl ether acetate, PEG/PPG-15/5 dimethyl siloxane, PEG/PPG-150/30 copolymer, bis-PEG/PPG-16/16 PEG/PPG-16/16 dimethyl siloxane, PEG/PPG-16/2 dimethyl siloxane, PEG/PPG-16/8Dimethicone, PEG/PPG-17/18 dimethicone, PEG/PPG-18/18 dimethicone, PEG/PPG-18/18 isostearate, PEG/PPG-18/18 laurate, PEG/PPG-18/6 copolymer, bis-PEG/PPG-18/6 dimethicone, PEG/PPG-19/19 dimethicone, PEG/PPG-20/15 dimethicone, PEG/PPG-20/20 dimethicone, bis-PEG/PPG-20/20 dimethicone, PEG/PPG-20/22 methyl ether dimethicone, PEG/PPG-20/29 dimethicone, bis-PEG/PPG-20/5 PEG/PPG-20/5 dimethicone, PEG/PPG-20/5 dimethicone, silicone, bis (silicone, bis (silicone, PEG/PPG-20/6 dimethylsiloxane, PEG/PPG-22/22 butyl ether dimethylsiloxane, PEG/PPG-22/23 butyl ether dimethylsiloxane, PEG/PPG-22/23 dimethylsiloxane, PEG/PPG-22/24 dimethylsiloxane, PEG/PPG-23/23 butyl ether dimethylsiloxane, PEG/PPG-24/18 butyl ether dimethylsiloxane, PEG/PPG-25/25 dimethylsiloxane, PEG/PPG-27/27 dimethylsiloxane, PEG/PPG-27/9 butyl ether dimethylsiloxane, PEG/PPG-3/10 dimethylsiloxane, PEG/PPG-30/10 dimethylsiloxane, PEG/PPG-32/3 di-ricinoleate, PEG/PPG-22/22 di-hydroxy-methyl-ethyl-propyl-ethyl-methyl-propyl-ethyl-propyl-ethyl-methyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl-propyl-ethyl, PEG/PPG-4/12 dimethyl siloxane, PEG/PPG-4/2 propyl heptyl ether, PEG/PPG-40/2 propyl heptyl ether, PEG/PPG-5/3 trisiloxane, PEG/PPG-6/11 dimethyl siloxane, PEG/PPG-6/2 cocoglyceride, PEG/PPG-6/2 propyl heptyl ether, PEG/PPG-7/2 propyl heptyl ether, PEG/PPG-8/13 diisostearate, PEG/PPG-8/14 dimethyl siloxane, PEG/PPG-8/2 propyl heptyl ether, PEG/PPG-8/3 diisostearate, PEG/PPG-8/3 laurate, pentaerythritol distearate, propylene glycol, propylene, Pentaerythritol tetraisostearate, neopentyl glycol diisostearate, neopentyl glycol dilaurate, hydrogenated phosphatidylcholine, egg yolk, phosphatidylglycerol, siberian red pine seed oil polyglycerol-6 ester, poloxamer 105 benzoate, poloxamer 182 dibenzoate, poloxamine 1101, poloxamine 1102, poloxamine 1104, poloxamine 1301, poloxamine 1302, poloxamine 1304, poloxamine 1307, poloxamine 1501, poloxamine 1508, poloxamine 304, poloxamine 504, poloxamine 604, poloxamine 701, poloxamine 702, poloxamine 704, poloxamine 707, poloxamine 901, poloxamine 904, poloxamine 908, poly (C6-14 olefins), polypropylene, and mixtures thereofAcid ester-29, polyester-6, polyglycerol-Glycine dimer Glycine oleate, polyglycerol-2 stearate, polyglycerol-4 oleate, polyglycerol-4 pentastearate, polyglycerol-4 stearate, polyglycerol-6 caprylate, polyglycerol-6 distearate, polyglycerol-6 laurate, polyglycerol-6 myristate, polyglycerol-6 octastearate, polyglycerol-6 oleate, polyglycerol-6 pentastearate, polyglycerol-6 polyricinoleate, polyglycerol-6 tristearate, polyglycerol-8 oleate, polyglycerol-8 stearate, polyglycerol-10 macadamia nut oleate, polyglycerol-10 diisostearate, polyglycerol-10 dioleate, Polyglycerol-10 distearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentaoleate, polyglycerol-10 mandelate, polyglycerol-10 behenate/eicosanoate, polyglycerol-10 bis (hydroxypropyl lauryl ether), polyglycerol-10 caprate, polyglycerol-10 caprylate, polyglycerol-10 cocoate, polyglycerol-10 decahydroxystearate, polyglycerol-10 decalinoleate, polyglycerol-10 cocoate, polyglycerol-10 didecanate, polyglycerol-10 dimyristate, polyglycerol-10 dipalmitate, polyglycerol-10 behenate, polyglycerol-10 dodecanoate, polyglycerol-10 dodecacaprylate, polyglycerol-10 heptaheptacosanoate/stearate, Polyglyceryl-10 hexaerucate, polyglyceryl-10 hexaisostearate, polyglyceryl-10 hexaoleate, polyglyceryl-10 hydroxypropylethylhexyl ether, polyglyceryl-10 hydroxypropyllauryl ether, polyglyceryl-10 lauryl ether, polyglyceryl-10 palmitate, polyglyceryl-10 pentacaprylate, polyglyceryl-10 pentalaurate, polyglyceryl-10 pentalinoleate, polyglyceryl-10 pentaricinoleate, polyglyceryl-10 polyhydroxystearate, polyglyceryl-10 sesquistearate, polyglyceryl-10 cocoate, polyglyceryl-10 tricaprate, polyglyceryl-12 bis (hydroxypropylethylhexyl ether), polyglyceryl-2 decanoate, polyglyceryl-2 caprylate, polyglyceryl-2 diisostearate, polyglyceryl-2 distearate, Polyglycerol-2-hydroxypropylethylhexyl ether, polyglycerol-2-hydroxypropyllauryl ether, polyglycerol-2-isononanoate/dilinoleate copolymer, polyglycerol-2-isopalmitate/sebacate, polyglycerol-2-lanolin alcohol ether, polyglycerol-2-laurate, polyglycerin-2-oleate, polyglycerin-2-laurate, and polyglycerin-2-laurate,Polyglycerol-2 lauryl ether, polyglycerol-2 myristate, polyglycerol-2 oleyl ether, polyglycerol-2 palmitate, polyglycerol-2 sesquicaprylate, polyglycerol-2 sesquioleate, polyglycerol-2 sesquistearate, polyglycerol-2 sorbitan tetraethylhexanoate, polyglycerol-2 tetraoleate, polyglycerol-2 tetrastearate, polyglycerol-2-PEG-4 stearate, polyglycerol-20 docosylate/isostearate, polyglycerol-20 docosylate/laurate, polyglycerol-20 docosylate/oleate, polyglycerol-20 heptacosyl/laurate, polyglycerol-20 octadecacosyl/laurate, polyglycerol-2-glyceryl sesquioleate, polyglycerol-2-PEG-4 stearate, polyglycerol-20 docosylate/isostearate, polyglycerol-20 docosylate/laurate, polyglycerol-20 octadecacosyl/laurate, Polyglycerol-20 octaisononanoate, polyglycerol-3 beeswax, polyglycerol-3 decanoate, polyglycerol-3 octanoate, polyglycerol-3 cetyl ether stearate, polyglycerol-3 cocoate, polyglycerol-3 decyltetradecyl ether, polyglycerol-3 didecanoate, polyglycerol-3 dicitrate/stearate, polyglycerol-3 cocoate, polyglycerol-3 dihydroxystearate, isopropylglycerol-3 dimethylsiloxane, isopropylglycerol-3 dimethiconol, polyglycerol-3 dioleate, polyglycerol-3 distearate, polyglycerol-3 hydroxylauryl ether, polyglycerol-3 hydroxypropylethylhexyl ether, Polyglycerol-3 hydroxypropyl lauryl ether, polyglycerol-3 isostearate, polyglycerol-3 laurate, polyglycerol-3 methylglucose distearate, polyglycerol-3 myristate, polyglycerol-3 oleyl ether phosphate, polyglycerol-3 palmitate, polyglycerol-3 pentaricinoleate, polyglycerol-3 polyricinoleate, polyglycerol-3 rice bran ester phosphate, polyglycerol-3 ricinoleate, polyglycerol-3 sorbitan flaxseed oleate, polyglycerol-3 soybean oleate/shea butter acid ester, polyglycerol-3 stearate SE, polyglycerol-3 triisostearate, polyglycerol-4, almond oleate/shea butter acid ester, Polyglycerol-4 caprate, polyglycerol-4 caprylate, polyglycerol-4 cocoate, polyglycerol-4 diisostearate/polyhydroxystearate/sebacate, polyglycerol-4 dilaurate, polyglycerol-4 distearate, polyglycerol-4 hazelnut oleate, polyglycerol-4 hydroxypropylethylhexyl ether, polyglycerol-4 isostearic acidAcid esters, polyglycerol-4 isostearate/laurate, polyglycerol-4 lauryl ether, polyglycerol-4 oleyl ether, polyglycerol-4 pentaoleate, polyglycerol-4 pentapalmitate/stearate, polyglycerol-4 polyricinoleate, polyglycerol-4 sorbitan olivetoleate phosphate, polyglycerol-4 sweet almond oleate, polyglycerol-4 tristearate, polyglycerol-4-PEG-2 cocamide, polyglycerol-5 bis (hydroxypropyl ethylhexyl ether), polyglycerol-5 decanoate, polyglycerol-5 dilaurate, polyglycerol-5 dioleate, polyglycerol-5 hexastearate, polyglycerol-5 hydroxypropyl lauryl ether, polyglycerol-5 isostearate, polyglycerol-4 glyceryl laurate, polyglycerol-4 pentapalmitate/stearate, polyglycerol-5 isostearate, polyglycerol-4 glyceryl stearate, polyglycerol-4 polyglyceryl oleate, polyglycerol-5 glyceryl oleate, polyglycerol-4 glyceryl stearate, polyglycerol-4 polyglyceryl 2 oleate, polyglycerol-5 bis (hydroxypropyl ethylhexyl ether), polyglycerol-5 isostearate, polyglycerol-4 lauryl ether, polyglycerol-4 glyceryl oleate, polyglycerol-4 stearate, polyglycerol-4 glyceryl oleate, polyglycerol-5 stearate, polyglycerol-5, and/stearate, Polyglycerol-5 laurate, polyglycerol-5 myristate, polyglycerol-5 oleate, polyglycerol-5 pentamyristate, polyglycerol-5 polyricinoleate, polyglycerol-5 stearate, polyglycerol-5 tribehenate, polyglycerol-5 triisostearate, polyglycerol-5 trimyristate, polyglycerol-5 trioleate, polyglycerol-5 tristearate, polyglycerol-6 macadamia nut oleate, polyglycerol-6 almond oleate, polyglycerol-6 argan oleate, polyglycerol-6 bis (hydroxypropyl ethylhexyl ether), polyglycerol-6 bis (hydroxypropyl lauryl ether), polyglycerol-6 decanoate, polyglycerol-6 watermelon seed oleate, polyglycerol-6 didecanoate, polyglycerol-5 myristyl oleate, polyglycerol-5 triisostearate, polyglycerol-5 trimyristate, polyglycerol-5 myristyl oleate, polyglycerol-5 trimyristate, polyglycerol-5 trioleate, polyglycerol-5 triol5 trioleate, polyglycerol-5 trioleate, polyglycerol-5-trioleate, polyglycerol-6-trioleate, polyglycerol-6-oleate, polyglycerol-6-triethanolamine trioleate, polyglycerol-6-oleate, polyglycerol-6-oleate, and/or, Polyglycerol-6 diisostearate, polyglycerol-6 dioleate, polyglycerol-6 dipalmitate, polyglycerol-6 heptacaprylate, polyglycerol-6 hexaoleate, polyglycerol-6 hexastearate, polyglycerol-6 isostearate, polyglycerol-6 myristyl ether, polyglycerol-6 palmitate/succinate, polyglycerol-6 pentaoleate, polyglycerol-6 pentaricinoleate, polyglycerol-6 polyhydroxystearate, polyglycerol-6 ricinoleate, polyglycerol-6 sesquiisostearate, polyglycerol-6 sesquistearate, polyglycerol-6 tetra behenate, polyglycerol-6 tetraoleate, polyglycerol-6 undecenoate and polyglycerol-8C._12-20Acid ester, polyhydroxy stearic acid, polyperfluoroethyloxymethoxy PEG-2 phosphate, polyquaternium-75, polyquaternium-77, polyquaternium-78, polyquaternium-79, polyquaternium-80, polyquaternium-81, polyquaternium-88, polysorbate 20, polysorbate 21, polysorbate 40, polysorbate 60, polysorbate 61Polysorbate 65, polysorbate 80 acetate, polysorbate 85, polyurethane-28, potassium babassu oleate, potassium cocoate oleate, potassium cocoyl rice amide, potassium corn oleate, potassium decyl polyether-4 phosphate, potassium dextrin octenyl succinate, potassium dimethyl silicone PEG-7 phosphate, potassium laurate, potassium lauryl polyether phosphate, potassium lauryl sulfate, potassium myristate, potassium octyl phenol polyether-12 phosphate, potassium oleate, potassium olive oleate, potassium palm oil, potassium arachis oleate, potassium PEG-50 hydrogenated castor oil succinate, potassium stearate, potassium tallowate, potassium camellianoate, potassium undecylenate, PPG-1 behenyl polyether-15, PPG-1 hydroxyethyl octanoamide, PPG-1 tridecyl polyether-13, PPG-1-decylether-4, PPG-1-decanol polyether-5, PPG-1-decanol polyether-6, PPG-1-decanol polyether-7, PPG-1-isodecanol polyether-4, PPG-1-isodecanol polyether-6, PPG-1-isodecanol polyether-7, PPG-1-isodecanol polyether-9, PPG-1-PEG-9 lauryl glycol ether, PPG-2C_12-13Alkanopolyether-8, PPG-2C_12-15PPG-2C 9-11-alkanol polyether-5, PPG-2C 9-11-alkanol polyether-7, PPG-2C 9-11-alkanol polyether-8, PPG-2 glycerol ether, PPG-2 hydroxyethyl cocamide, PPG-2 isocetyl polyether-20 acetate, PPG-2 lanolin alcohol ether, PPG-2-cetostearyl ether-9, PPG-2-decyl alcohol polyether-10, PPG-2-decyl alcohol polyether-12, PPG-2-decyl alcohol polyether-15, PPG-2-decyl alcohol polyether-20, PPG-2-decyl alcohol polyether-3, PPG-2-decyl alcohol polyether-30, PPG-2-decyl alcohol polyether-40, PPG-2-decanol polyether-5, PPG-2-decanol polyether-50, PPG-2-decanol polyether-60, PPG-2-decanol polyether-7, PPG-2-decanol polyether-8, PPG-2-isodecanol polyether-10, PPG-2-isodecanol polyether-12, PPG-2-isodecanol polyether-18, PPG-2-isodecanol polyether-25, PPG-2-isodecanol polyether-4, PPG-2-isodecanol polyether-6, PPG-2-isodecanol polyether-8, PPG-2-isodecanol polyether-9, PPG-2-laureth-12, PPG-2-laureth-5, PPG-2-laureth-8, PPG-2-PEG-11 hydrogenated lauryl alcohol ether, PPG-2-PEG-6 coconut oil ester, PPG-2/PEG-8 cocoate, PPG-3C_12-14Secondary alkanol polyether-7, PPG-3 glycerol ether, PPG-3 hydroxyethyl soybean oil amide, PPG-3 decyl alcohol polyether-2 carboxylic acid, PPG-3 isostearyl alcohol polyether-9, PPG-3 laureth-10, PPG-3 laureth-12, PPG-3-laureth-8, PPG-3-laureth-9, PPG-3-myristyl polyether-11, PPG-3-myristyl polyether-3, PPG-3-PEG-6 oleyl ether, PPG-4C_12-14Secondary alkanol polyether-7, PPG-4C_12-14Sec-alkanol polyether-5, PPG-4C13-15 alkanol polyether-15, PPG-4 lauryl polyether-7, PPG-4 tridecanol polyether-6, PPG-4-cetearyl polyether-12, PPG-4-cetyl polyether-10, PPG-4-cetyl polyether-20, PPG-4-decyl alcohol polyether-4, PPG-4-decyl alcohol polyether-6, PPG-4-isodecyl alcohol polyether-10, PPG-5C_12-14Secondary alkanol polyether-7, PPG-5C_12-14Secondary alkanolamine-9, PPG-5C9-15 alkanolamine-6, PPG-5 phytosterol, PPG-5-cetyleth-20, PPG-6C12-18 alkanolamine-11, PPG-6 glyceryl ether, PPG-6 trideceth-8, PPG-6-decylpolyether-9, PPG-6-decyltetradecyltetraeth-12, PPG-6-decyltetradecylteth-20, PPG-6-decyltetradecylteth-30, bis- (PPG-7 undeceneth-21) dimethylsiloxane, PPG-7/PEG-30 phytosterol, PPG-8 glyceryl ether, PPG-8 polyglycerol-2 ether, PPG-8-cetyleth-20, PPG-5 phytosterol-8, PPG-8-decylether-6, PPG-9 glyceryl ether, PPG-9-ethylhexanol-5, PPG-10 glyceryl ether, PPG-10 jojoba alcohol, PPG-10 lanoline alcohol ether, PPG-10-ceteareth-20, PPG-12 octanol polyether-18, PPG-12 diglucosyl C14-18 acid ester, PPG-12-lanolin alcohol polyether-50, PPG-12-PEG-65 lanolin oil, PPG-13 decyltetradecyl polyether-24, PPG-14 diglycerol ether, PPG-14 polyglycerin-2 ether, PPG-14-decylteth-6, PPG-16 glyceryl ether, PPG-20 lanolin alcohol ether, PPG-20-decyltetradecyl polyether-10, PPG-14 glyceryl ether, PPG-21 butyl ether phosphate, PPG-23-PEG-4 trimethylolpropane, PPG-23-steareth-34, PPG-25 butyl ether phosphate, PPG-25 glyceryl polyether-22, PPG-27 glyceryl ether, PPG-30 ethyl hexanol polyether-4 phosphate, PPG-30 lanolin alcohol ether, PPG-30 stearyl ether-4, PPG-34 stearyl polyether-3, PPG-35 butyl ether phosphate, PPG-40-PEG-60 lanolin oil, PPG-50 glyceryl ether, PPG-10 cetyl ether phosphate, PPG-12-PEG-50 lanolin, PPG-24 glyceryl polyether-24, PPG-25-laureth-25, PPG-5-cetyl polyether-10 phosphate, PPG-5-stearyl polyether-10 phosphate, PPG-25-ethyl hexanol polyether-4, PPG-30 lanolin alcohol ether, PPG-30 stearyl ether-4, PPG-34 glyceryl polyether-3, PPG-35 butyl ether phosphate, PPG-40-60 glyceryl ether-60, PPG-10 glyceryl ether-10, PPG-5-cetyl ether-10 phosphate, PPG, and their salts, PPG-5-laureth-5, PPG-6C_12-15Alkanopolyether-12, PPG-6C9-11, PPG-6-decanolPolyether-4, PPG-66 glyceryl polyether-12, PPG-9 diethyl methyl ammonium chloride, PPG/PEG-2/10 glyceryl cocoate, isopropyl lanolate, isopropyl triisostearate titanium isopropoxide salt, propylene glycol decyl polyether-4, propylene glycol cocoate, propylene glycol hyaluronate, propylene glycol isodecyl polyether-4, propylene glycol oleate SE, propylene glycol oleyl polyether-5, propylene glycol ricinoleate, propylene glycol stearate SE, pumpkin seed oil PEG-8 ester, quaternary ammonium salt-90 montmorillonite, quaternary ammonium salt-92, quillaja bark extract, raffinose myristate, raffinose oleate, rapeseed glucoside, rapeseed olein, hydrogenated rapeseed olein, rapeseed oil PEG-3 ester, PEG-20 ester of rapeseed oil, sorbitol ester of rapeseed oil, PEG-8 ester of raspberry seed oil, rhamnolipid, polyglycerol-3 ester of rice bran oil, diglyceride of rice oil, (Z) -, ricinoleic acid, polyether-40 of ricinoleic acid, PEG-8 ester of russet red rose seed oil, extract of fermentation product of saccharomycetes/stevia rebaudiana leaves/stems, PEG-8 ester of safflower seed oil, polyglycerol-6 ester of safflower seed oil, PEG-8 ester of dampery seed oil, polyglycerol-6 ester of dampery seed oil, PEG-8 ester of dampery seed oil, polyglycerol-6 ester of bery seed oil, polyglycerol-10 ester of bery seed oil, polyglycerol-6 ester of sesame seed oil, PEG-8 ester of sesame seed oil, DIPA amide, shea butter polyether-8 ester of glycerol, Shea butter glyceride, shea butter PEG-8 ester, shea butter PEG-32 ester, shea butter polyglycerol-6 ester, shea butter amidopropyl trimethyl ammonium chloride, organosilicon quaternary ammonium salt-17, organosilicon quaternary ammonium salt-21, sodium avocado, beeswax sodium, sodium behenyl lactylate, diethylene glycol ricinoleate sodium sulfosuccinate, butyl phenol polyether-12 sodium sulfate, butyl glucoside sodium hydroxypropyl phosphate, C10-15 alkanol polyether sodium sulfate, C_11-15Sodium alkanol polyether-7 carboxylate, C_12-13Sodium alkanol polyether sulfates, C_12-13Sodium alkanol polyether-12 carboxylate, C_12-13Sodium alkanol polyether-5 carboxylate, C_12-13Sodium alkanol polyether-8 carboxylate, C_12-14Sodium alkanol polyether-3 sulfate, C_12-15Sodium alkyl sulfate, C_12-15Sodium alkanol polyether sulfates, C_12-15Alkanol polyethers15 sodium sulfonate, C_12-15Sodium alkanol polyether-3 sulfonate, C_12-15Sodium alkanol polyether-6 carboxylate, C_12-15Sodium alkanol polyether-7 carboxylate, C_12-15Sodium alkanol polyether-7 sulfonate, C_12-15Sodium alkanol polyether-8 carboxylate, sodium C12-18 alkyl sulfate, sodium C13-15 alkanol polyether-8 butyl phosphate, sodium C13-15 alkanol polyether-8 phosphate, C_14-15Sodium alkanol polyether-8 carboxylate, sodium C16-20 alkyl sulfate, sodium C9-11 alkanol polyether-6 carboxylate, sodium decanoyl lactylate, sodium caprylate, sodium octanol polyether-9 carboxylate, sodium octanoyl amphoteric hydroxypropyl sulfonate, sodium octyl sulfonate, sodium carboxydecyl PEG-8 dimethyl siloxane, carboxymethyl C_10-16Sodium alkyl glucoside, sodium carboxymethyl chitosan lauramide, sodium ricinoleate, sodium ceteth-13 carboxylate, sodium ceteth-4 phosphate, sodium cetyl sulfate, sodium chitosan cocoamide hydroxypropyl sulfate, sodium chitosan lauramide hydroxypropyl sulfate, sodium cocoyl sulfoacetate, sodium cocoyl glucoside tartrate, sodium cocoyl/babassu sulfate, sodium cocoyl/hydrogenated tallow sulfate, sodium cocoyl glucoside hydroxypropyl phosphate, sodium cocoyl glucoside hydroxypropyl sulfonate, sodium cocoyl sulfate, sodium cocoyl barley amino acid, sodium cocoyl lactylate, sodium cocoyl threonine, sodium cocoyl/palmitoyl/sunflower oleoyl glutamate, cocoyl/stearoyl (alanine/arginine/asparagine/aspartic acid/glutamic acid/glutamine/glycine/histidine/sodium cocoyl isole, sodium decylpolyether sulfate, sodium decylpolyether-2 carboxylate, sodium decylglucose hydroxypropyl sulfonate, sodium dicetyl steareth-10 phosphate, sodium dilaureth-4 phosphate, sodium dilaureth-7 citrate, sodium dioleeth-8 phosphate, sodium glyceryl oleate phosphate, sodium lauryl dimethyl ammonium ethyl phosphate, sodium hydroxypropyl sodium phosphate decyl glucoside cross-linked polymer, sodium hydroxypropyl sodium phosphate lauryl glucoside cross-linked polymer, sodium hydroxypropyl sodium sulfonate coco glucoside cross-linked polymer, sodium hydroxypropyl sodium sulfonate decyl glucoside cross-linked polymer, sodium hydroxypropyl sodium sulfonate lauryl glucoside cross-linked polymer, sodium isostearate, sodium isosteareth-11 carboxylate, sodium isosteareth polySodium ether-6 carboxylate, sodium isostearoyl lactate, sodium isostearoyl lactylate, sodium lard, sodium lauraminopropionate, sodium laurate, sodium laureth sulfate, sodium laureth-2 phosphate, sodium laureth-3 carboxylate, sodium laureth-13 carboxylate, sodium laureth-4 phosphate, sodium lauroylmethylaminopropionate, sodium lauryl phosphate, sodium lauryl sulfate, sodium lauryl glucoside hydroxypropyl phosphate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium linoleate, sodium macadamia nut oil, sodium mango seed oil, sodium methoxy-2 acetate, sodium methyl isethionate, sodium methyl cocoyl methyl taurate, sodium myristyl polyether sulfate, sodium myristate, sodium myristyl sulfate, sodium octyl phenol polyether-2 ethyl sulfonate, sodium lauryl sulfate, sodium lauryl methyl taurate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium lauryl sulfate, sodium lauryl ether-2 ethyl sulfonate, sodium lauryl phenol polyether-2 ethyl sulfonate, sodium lauryl sulfate, sodium lauryl phenol polyether-2 ethyl sulfonate, sodium lauryl ether sulfate, sodium lauryl methyl ester, sodium lauryl methyl ethyl methyl ester, sodium lauryl methyl glucoside, sodium lauryl sulfate, sodium lauryl glucoside sodium lauryl sulfate, sodium lauryl ether-2 ethyl sulfonate, sodium lauryl sulfate, sodium, Sodium octylphenol polyether-6 sulfate, sodium octylphenol polyether-9 sulfate, sodium lactoyl lactate, sodium oleyl polyether sulfate, sodium oleyl polyether-7 phosphate, sodium oleyl polyether-8 phosphate, sodium oleyl sulfate, sodium palmitate, sodium arachidate, sodium PEG-3 lauramido carboxylate, sodium PEG-4 lauramido carboxylate, sodium PEG-50 hydrogenated castor oil succinate, sodium PEG-6 cocoamido carboxylate, sodium PEG-8 cocoamido carboxylate, sodium propoxy PPG-2 sodium acetate, sodium rapeseed oleate, sodium ricinoleate propyl PG-dimethyl ammonium chloride phosphate, sodium sesame seed oleate, sodium soyate, sodium steareth-4 phosphate, sodium stearyl amphohydroxypropyl sulfonate, sodium stearyl glutamate, sodium stearoyl lactylate, sodium stearyl dimethylglycinate, sodium stearoyl lactylate, sodium stearyl lactylate, sodium lauryl lactylate, sodium oleyl lactylate, sodium linoleate, sodium oleyl-4 phosphate, sodium stearyl ampho-8 phosphate, sodium stearyl lactylate, sodium lauryl lactylate, sodium lauryl lactylate, sodium lauryl lactylate, sodium lauryl sodium chloride, sodium lauryl sodium chloride, sodium lauryl sodium stearate, sodium chloride, sodium lauryl sodium chloride, sodium lauryl sodium, Sodium stearyl phthalate, sodium stearyl sulfate, sodium surfactin, sodium amygdalate, sodium tallowate, sodium cocoyl methyl taurate, sodium trideceth sulfate, sodium undecyl sulfate-5 carboxylate, sodium laureth-2 sulfosuccinate/MEA, PEG-3 sodium cocoyl amide sulfate/MEA, sorbitan-2 beeswax, sorbitan-2 cocoyl oleate, sorbitan-3 isostearate, sorbitan-3 tristearate, sorbitan-4 tetraoleate, sorbitan-5, sorbitan-6 beeswax, sorbitan-6 hexastearate, sorbitan-6 laurate, sorbitan-6 tetraoleate, sodium laureth-6 taurate, sodium cocoyl taurate, sodium laureth-6 oleate, sodium cocoyl taurate, sodium laureth-5 cocoyl ether sulfate, sodium laureth-2 sulfonate, sodium laureth-2 cocoyl ether-2, sodium laureth-3 isostearate, sorbitan-3 tristearate, sorbitan polyether-4 tetraoleate, sorbitan polyether-5, sorbitan polyether-6 beeswax, sorbitan polyether-6 hexastearate, sorbitan hexaoleate, sodium laureth-6, sodium lauryl ether-6, sodium laureth-6, sodium lauryl ether, sodium cocoate, sodium cocoyl ether-2, Sorbitol polyether-7, sorbitol polyether-8 beeWax, sorbitan polyether-20 pentaisostearate, sorbitan polyether-20 tetraisostearate, sorbitan polyether-30 pentaisostearate, sorbitan polyether-30 tetraisostearate, sorbitan polyether-30 tetraoleate laurate, sorbitan polyether-40 pentaisostearate, sorbitan polyether-40 pentaoleate, sorbitan polyether-40 tetraisostearate, sorbitan polyether-50 pentaisostearate, sorbitan polyether-50 tetraisostearate, sorbitan polyether-60 tetrastearate, sorbitan polyether-20 beeswax, sorbitan polyether-30 tetraoleate, sorbitan polyether-40 tetraoleate, sorbitan polyether-50 hexaoleate, sorbitan polyether-6, sorbitol polyether-30, sorbitan polyether-40 tetraoleate, sorbitan polyether-50 hexaoleate, Sorbitan polyether-60 tetraoleate, isosorbide laurate, sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan isostearate, sorbitan laurate, sorbitan oleate decyl glucoside cross-linked polymer, sorbitan oleate lauryl glucoside cross-linked polymer, sorbitan olivil oleate, sorbitan palmitate, sorbitan sesquiisostearate, sorbitan sesquioleate (2:3), sorbitan sesquistearate, sorbitan stearate, sorbitan triisostearate, sorbitan trioleate, sorbitan tristearate, sorbitan caprylate, sorbitan distearate, sorbitan dioleate, sorbitan monolaurate, sorbitan caprylate, sorbitan monolaurate, and sorbitan monolaurate, and sorbitan monolaurate, Sorbitan undecylenate, sorbitol acetate, sorbitol laurate, soya acid, hydrogenated soya polyglycerol/soya amide DEA, soya sterol acetate, soya amide DEA, soya amidopropyl dimethylamine, soya amine, soya aminopropylamine, soya oil PEG-8 ester, soya oil PEG-20 ester, soybean oil PEG-36 ester, soybean oil polyglycerol-6 ester, soybean oleyl trimethyl ammonium chloride, stearamide ethyl ethanolamine, isostearamide morpholine stearate, stearamide propyl dimethylamine stearate, stearyl dimethyl ammonium chloride hydroxypropyl trimethyl ammonium chloride, steareth-1, steareth-2, isosteareth-2, steareth-2 phosphate, steareth-3 and isosteareth poly.Ether-3, steareth-4, steareth-5, isosteareth-5, steareth-5 stearate, steareth-6, isosteareth-6 carboxylic acid, steareth-7, steareth-8, steareth-10, isosteareth-10 stearate, steareth-11, isosteareth-11 carboxylic acid, steareth-12, isosteareth-12, steareth-13, steareth-14, steareth-15, isosteareth-15, steareth-16, steareth-20, isosteareth-20, steareth-21, isosteareth-22, isosteareth-5 stearate, steareth-10-15, isosteareth-15, steareth-16, steareth-20, isosteareth-20, steareth-21, isosteareth-22, Steareth-25, isosteareth-50, isosteareth-2 phosphate, steareth-200, isosteareth-200 palmitate, glyceryl isostearate/myristate, stearoyl amphoacetic acid, stearoyl ethyltrimethyl ammonium methosulfate, stearoyl inulin, stearoyl lactyl lactic acid, stearoyl leucine, stearyl acetylglutamate, stearyl alcohol, isostearyl carboxydecyl PEG-8 dimethylsiloxane, isostearyl glucoside, stearyl olivate oleate, stearyl PG-trimethylammonium chloride, stearyl phosphate, stearyl dimethyl hydroxypropyl butyl glucoside ammonium chloride, stearyl dimethyl hydroxypropyl decyl glucoside ammonium chloride, stearyl dimethyl hydroxypropyl lauryl glucoside ammonium chloride, stearyl dimethyl lauryl sulfate, stearyl alcohol isopropyl glyceryl ether/myristyl ammonium chloride, stearyl dimethyl lauryl sulfate, stearyl ethyl trimethyl ammonium methosulfate, stearyl inulin, stearyl lactylate, stearyl leucine, stearyl alcohol acetyl glutamate, stearyl alcohol lauryl glucoside, stearyl alcohol lauryl ammonium chloride, stearyl alcohol lauryl sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol lauryl alcohol sulfate, stearyl alcohol sulfate, Sucrose cocoate, sucrose dilaurate, sucrose distearate, sucrose hexaerucate, sucrose hexaoleate/hexapalmitate/hexastearate, sucrose hexapalmitate, sucrose ascosporolate, sucrose myristate, sucrose oleate, sucrose palmitate, sucrose pentaerucate, sucrose polybehenate, sucrose polycottonseed oleate, sucrose polylaureate, sucrose polyitaconate, sucrose polypalmitate, sucrose soyaoleate, sucrose polystearate, sucrose ricinoleate, sucrose tetraisostearate, sucrose tetrastearate triacetate, sucrose tribehenate, sucrose trilaurate, sucrose tristearate, sunflower glyceride citrate, sunflower seed oil glyceryl polyether-8 ester, sunflower seed oil glyceride, sunflower seed oil glyceryl ester mixture, sunflower seed oil PEG-32 ester, Sunflower seed oil PEG-8 ester and sunflower seed oilPolyglycerol-10 ester, sunflower seed oil polyglycerol-3 ester, sunflower seed oil polyglycerol-4 ester, sunflower seed oil polyglycerol-5 ester, sunflower seed oil polyglycerol-6 ester, sunflower seed oil sorbitol ester, hydrogenated tallow acid, tallow amine, acetylated hydrogenated tallow glyceride, hydrogenated tallow glyceride citrate, hydrogenated tallow glyceride lactate, tallow glyceride, acetylated hydrogenated tallow glyceride mixture, hydrogenated tallow glyceride citrate mixture, hydrogenated tallow methylamine, hydrogenated tallow phthalic acid amide, tallow aminopropylamine, tallow pentamethyl propylene dichloride, tallow alcohol polyether-5, tallow alcohol polyether-7, hydrogenated tallow alcohol polyether-12, tallow alcohol polyether-18, hydrogenated tallow alcohol polyether-25, hydrogenated tallow alcohol polyether-60 myristyl glycol, Tallow polyether-4, tallow polyether-6, C_11-15Alkanolpolyether sulfate TEA salt, C_12-13TEA salts of alkanol polyether-3 sulfate, TEA salts of canola oil acid, TEA salts of coconut oil acid, TEA salts of cocoyl glycine, TEA salts of dextrin octenyl succinate, TEA salts of diethanol aminoethyl polyisobutenyl succinate, TEA salts of dimethyl siloxane PEG-7 phosphate, TEA salts of isostearic acid, TEA salts of lanolin alcohol polyether-5 sulfate, TEA salts of lauric acid/myristic acid, TEA salts of laureth sulfate, TEA salts of laureth-4 phosphate, TEA salts of lauroyl lactylate, TEA salts of lauryl sulfate, TEA salts of myristic acid, TEA salts of oleic acid, TEA salts of oleyl sulfate, TEA salts of palmitic acid, TEA salts of PEG-3 cocamide sulfate, TEA salts of PEG-50 hydrogenated TEA oil succinate, TEA salts of stearic acid, TEA salts of tall acid, TEA salts of dicarboxyethyl stearyl sulfosuccinate tetrasodium salt, Theobroma grandiflorum seed butter glyceride, Theobroma grandiflorum seed butter PEG-8 ester, Theobroma grandiflorum seed butter polyglycerol-6 ester, TIPA lauryl sulfate salt, TIPA stearate salt, tocopherol phosphate, tri-C_12-15Alkanopolyether-10 phosphate, tri-C_12-15Alkanopolyether-2 phosphate, tri-C_12-15Alkanopolyether-6 phosphate, tri-C_12-15Alkyl polyether-8 phosphate, arachidyl alcohol, behenyl alcohol PEG-20 ester, tricetyl stearyl ether-4 phosphate, tricetyl polyether-5 phosphate, Natalolheart seed oil PEG-8 ester,Natalor mahogany seed oil polyglycerol-6 ester, tridecyl alcohol polyether-2, tridecyl alcohol polyether-3 phosphate, tridecyl alcohol polyether-4, tridecyl alcohol polyether-5, tridecyl alcohol polyether-6 phosphate, tridecyl alcohol polyether-7, tridecyl alcohol polyether-8, tridecyl alcohol polyether-9, tridecyl alcohol polyether-10 phosphate, tridecyl alcohol polyether-12, tridecyl alcohol polyether-15 carboxylic acid, tridecyl alcohol polyether-18, tridecyl alcohol polyether-20, tridecyl alcohol polyether-50, trifluoropropyldimethyl siloxane/PEG-10 cross-linked polymer, trilosanol alcohol polyether-4 phosphate, trilauryl alcohol polyether-4 phosphate, tridecyl alcohol polyether-7, Trilauryl polyether-9 citrate, triolein PEG-6 ester, triolein polyether-8 phosphate, dimethyl siloxane undecanoate, undeceteth-3, undeceteth-5, undeceteth-7, undeceteth-8, undeceteth-9, undeceteth-11, hydrolyzed VA/acetoacetate copolymers, hydrogenated vegetable glycerides, hydrogenated vegetable glyceride citrates, vegetable glyceride phosphates, hydrogenated vegetable glyceride phosphates, watermelon seed oil PEG-8 ester, watermelon seed oil polyglycerol-10 ester, watermelon seed oil polyglycerol-6 ester, wheat germ oil polyether-8 ester, wheat germ oil PEG-8 ester, xanthan gum, sandalwood seed oil PEG-8 ester, sandalwood seed oil polyglycerol-6 ester, glyceryl stearate, the use in the salts of hydrogenated esters of hydrogenated oils, in the salts of which are provided, Zinc coco polyether sulfate, zinc coco sulfate, and mixtures thereof.

The lotion can also comprise a thickening agent. The thickening agent helps to stabilize the lotion. Thickeners also help make lotions more appealing for use. Examples of thickeners include agar, brown algae (Laminaria and other seaweeds), alginic acid, magnesium aluminum metasilicate, ammonium alginate, tragacanth, attapulgite, biotite, tara gum, calcium alginate, calcium carrageenan, gelatin, cellulose, regenerated cellulose, guar gum, dextrin, ethylhydroxyethyl cellulose, gellan gum, ghatti gum, hydrogenated rapeseed oil, lithium magnesium silicate, methylethyl cellulose, pectin, potassium alginate, potassium carrageenan, propylene glycol alginate, sodium carboxymethylcellulose, sodium carrageenan, sodium hydroxypropyl starch phosphate, sodium magnesium silicate, sodium sulfate, karaya gum, synthetic fluorphlogopite, vinyl dimethyl/trimethylsiloxysilicate stearyl dimethylsiloxane crosspolymer, vinyl dimethyl/trimethylsiloxysilicate stearyl dimethylsilicone crosspolymer, Xanthan gum and mixtures thereof.

The lotion can also comprise a fragrance. For aesthetic purposes, fragrances may be used to provide an odor to the lotion prior to the patient applying it to the patient's skin. Alternatively or additionally, a fragrance may be used to provide an aftertaste after the lotion is applied to the patient's skin. Examples of usable aromatics include verbena aromatic, acacia aromatic, agate aromatic, aldehyde aromatic, allspice aromatic, almond aromatic, aloe oil aromatic, aloe aromatic, almond coffee aromatic, amber aromatic, sporty amber aromatic, amber nutmeg aromatic, amber pink aromatic, romantic amber aromatic, ambergris aromatic, ambroxol tertiary alcohol aromatic, ambrosia aromatic, angell dust aromatic, angel perfume aromatic, angel feather aromatic, angel wing aromatic, animal aromatic, anise aromatic, apple flower aromatic, apple jam aromatic, apple vinegar aromatic, apple cinnamon aromatic, apple cranberry aromatic, apple shortbread aromatic, apple aromatic, roasted apple aromatic, apple candy aromatic, green apple aromatic, orange green aromatic, orange, red apple fragrance, apple pear fragrance, apple pie fragrance, apple spice fragrance, apricot mango fragrance, apricot peach fragrance, aromatic costustoot and citrus flower fragrance, autumn fragrance, avocado fragrance, azalea fragrance, baby powder fragrance, bacon fragrance, balsam fragrance, bamboo fragrance, banana butter pie fragrance, banana nut bread fragrance, banana nut cake fragrance, banana pudding fragrance, cassia oil perfume fragrance, bayberry fragrance, bergamot flower fragrance, bergamot fragrance, berry fragrance, chinaberry fragrance, wild berry fragrance, berry jam fragrance, paradise fragrance, blackberry vanilla fragrance, blue grass fragrance, blue reef fragrance, blueberry fragrance, green pepper fragrance, red pepper fragrance, blueberry marfan aroma, blueberry pie aroma, ludwith ebony aroma, polo flower aroma, bouquet aroma, buwaler aroma, boysenberry aroma, brazil nut aroma, baked bread aroma, birch aroma, bubble gum aroma, cream aroma, butter rum aroma, butter vanilla aroma, cream candy aroma, cactus flower aroma, cake aroma, pound cake aroma, red velvet cake aroma, spice cake aroma, camellia aroma, cushaw aroma, candle aroma, candy with corn, melon aroma, cappuccino aroma, corn aroma, caramel aroma, carnation aroma, carrot cake aroma, kesimi aroma, cinnamon aroma, castor aroma, corn aroma, sesame aroma, sesame aroma, sesame aroma, sesame aroma, and so forth in the like, Cedrol aroma, cedar wood aroma, chamomile aroma, gardenia aroma, cherry berry aroma, cherry soap aroma, cherry aroma, black cherry aroma, sour cherry aroma, wild cherry aroma, roasted chestnut aroma, chocolate cherry aroma, chocolate cookie aroma, chocolate aroma, black chocolate aroma, white chocolate aroma, chocolate hazelnut aroma, chocolate mint aroma, chocolate orange aroma, chocolate raspberry aroma, Christmas aroma, chrysanthemum aroma, bisexual blue aroma, cinnamon roll aroma, cinnamon cookie aroma, cinnamon aroma, citronella aroma, citrus basil aroma, citrus bergamot aroma, citrus floral aroma, citrus green aroma, citrus fragrance aroma, citrus cookie, citrus fragrance, citrus cookie, citrus cookie, citrus, citrus aromatics, citrus ginger aromatics, citrus green aromatics, citrus grass aromatics, citrus flax aromatics, citrus mint aromatics, citrus rose aromatics, citrus sage aromatics, citrus vanilla aromatics, citrus costustoot aromatics, musk cat aromatics, flax cleaner aromatics, clematis aromatics, clove aromatics, clover aromatics, cocoa butter aromatics, coconut butter pie aromatics, coconut aromatics, tropical coconut aromatics, coconut kiwi aromatics, coconut lime verbena aromatics, coconut papaya aromatics, coffee aromatics, cognac aromatics, cologon aromatics, cologne aromatics, cookie dough aromatics, tangkuzu aromatics, cockscomb aromatics, cotton candy aromatics, mango aroma, orange peel, clean cotton fragrance, sponge fragrance, country meadow fragrance, crabapple fragrance, cranberry orange fragrance, cranberry fragrance, cream caramel pudding fragrance, cucumber melon fragrance, cucumber rose melon fragrance, gooseberry fragrance, blackcurrant fragrance, redcurrant fragrance, primrose fragrance, daffodil fragrance, margarine fragrance, daisy fragrance, davilni fragrance, date fragrance, body fragrance, pink fragrance, dill fragrance, dogwood fragrance, dragon blood fragrance, clay fragrance, egg wine fragrance, rose fragrance, elderberry fragrance, evergreen tree fragrance, fagonian fragrance, fennel fragrance, fern fragrance, holiday fragrance, fig fragrance, earth fragrance, egg wine fragrance, rose fragrance, elderberry fragrance, evergreen tree fragrance, fagonian fragrance, fennel fragrance, festival fragrance, fig fragrance, etc, Corylus heterophylla aromatic, fine aromatic, Canadian balsam aromatic, fir aromatic, floral aldehyde aromatic, all-flower aromatic, floral aromatic, citrus floral aromatic, fruity floral aromatic, green floral aromatic, spicy floral aromatic, woody floral aromatic, floral fruity floral aromatic, floral green aromatic, floral musk aromatic, floral oriental aromatic, floral powdery aromatic, floral costustoot aromatic, floral bouquet aromatic, forest aromatic, forget-me-not aromatic, fragrant herbal aromatic, fragrant costus aromatic, frankincense aromatic, freesia aromatic, fresh clean aromatic, cocktail aromatic, fruity green aromatic, fungal aromatic, gardenia lily aromatic, kitten aromatic, geranium aromatic, chamaejasmonic aromatic, freesia aromatic, fresh clean aromatic, cocktail aromatic, fruity green aromatic, fungal aromatic, gardenia aromatic, lily aromatic, kitten aromatic, geranium aromatic, geranium aromatic, geranium, Ginger aroma, ginger lily aroma, ginger peach aroma, ginger oat aroma, ginger vanilla aroma, ginger cake aroma, gooseberry aroma, gulfweed aroma, whole wheat biscuit aroma, grape aroma, scord grape aroma, grapefruit ginger aroma, grapefruit mango aroma, grapefruit sage aroma, grass aroma, calamus aroma, green aroma, spring green aroma, green vanilla aroma, green leaf aroma, greenhouse aroma, pomegranate syrup aroma, guava mandarin aroma, habuba aroma, hair care aroma, hawthorn aroma, coffee aroma, hazelnut butter aroma, hazelnut aroma, south china aroma, mustardserve aroma, herbal aroma, hibiscus aroma, hazelnut aroma, honey, oil, honey, etc., oil, or oil, wintergreen berry fragrance, home care fragrance, honey almond fragrance, honey rose fragrance, honeydew fragrance, honeysuckle fragrance, hops fragrance, cowberry fruit fragrance, hyacinth fragrance, hydrangea fragrance, incense fragrance, iris fragrance, ivy fragrance, jasmine carnation fragrance, jasmine lily magnolia fragrance, jasmine vanilla fragrance, jonquil fragrance, succulent fruit fragrance, juniper berry fragrance, juniper sage fragrance, pimpinella fragrans fragrance, lime fragrance, kiwi coconut fragrance, kiwi berry strawberry fragrance, kumquat fragrance, lavandin fragrance, lavender vanilla fragrance, honey dew fragrance, honeysuckle fragrance, hops, leather fragrance, Russian leather fragrance, leather costustoot fragrance, lemon balm fragrance, lemon bergamot fragrance, lemon flower fragrance, lemon chiffon fragrance, lemon cucumber fragrance, lemon lime fragrance, lemon pie fragrance, lemon thyme fragrance, raspberry lemon soda fragrance, lemon grass fragrance, licorice Eurasian fragrance, clove flower fragrance, lily fragrance, water lily fragrance, lotus flower fragrance, lily bulb fragrance, orange cream fragrance, lime sherbet fragrance, linden fragrance, loganberry fragrance, lotus fragrance, lychee fragrance, nutmeg seed fragrance, magnolia fragrance, maja fragrance, malt fragrance, citrus mandarin fragrance, citrus lemon fragrance, and the like, Citrus and rose aroma, mango and citrus aroma, mango and floral aroma, mango and citrus aroma, mango and melon aroma, mango and peach aroma, maple aroma, lime margarita aroma, marine aroma, almond and white soft candy aroma, meadowsweet aroma, medicinal aroma, melon aroma, citrus and melon aroma, midnight exciting aroma, milk aroma, mimosa aroma, mint aroma, mistletoe aroma, mocha aroma, plum aroma, morning glory aroma, moss rose aroma, mulberry aroma, muscadine aroma, musk aroma, chinese musk aroma, citrus and musk aroma, musk heavy musk aroma, eggype and musk aroma, floral musk aroma, fruit and musk aroma, mulberry and musk aroma, lemon and musk aroma, lemon and musk aroma, and lemon aroma, A jasmine musk fragrance, a light musk fragrance, an oriental musk fragrance, a costus musk fragrance, a myrrh fragrance, a narcissus fragrance, a nectar fragrance, an orange oil fragrance, a mohair fragrance, a nutmeg fragrance, an oat milk and honey fragrance, an oat grape cookie fragrance, an orange flower fragrance, an orange chiffon fragrance, an orange cinnamon fragrance, an orange clove fragrance, an orange cranberry fragrance, an orange cream fragrance, an orange ginger fragrance, an orange jam fragrance, an orange sher fragrance, an orange spice fragrance, an orange vanilla fragrance, an orchid magnolia fragrance, an oriental aldehyde fragrance, an oriental citrus fragrance, an oriental pink fragrance, an orris fragrance, an osmanthus fragrance, a fresh outdoor fragrance, a pansy fragrance, a kaffir fragrance, a kaki fragrance, a rose fragrance, a kaki fragrance, a rose fragrance, papaya fragrance, papaya mango fragrance, papaya saffron fragrance, nocturnal flower fragrance, passion blossom fragrance, passion fruit fragrance, patchouli costus amber fragrance, peach flower fragrance, nectarine pecan fragrance, nectarine cream fragrance, peanut butter cookie fragrance, peanut fragrance, pear berry fragrance, pear flower fragrance, pear spice fragrance, pecan pie fragrance, peony fragrance, peppermint fragrance, personal wash fragrance, orange leaf fragrance, petunia fragrance, oleander fragrance, iced fruit juice rum fragrance, pinocera fragrance, pine fragrance, Christmas pine fragrance, pineapple fragrance, pinon fragrance, pistachio fragrance, pizza fragrance, plum fragrance, pine fragrance, peach blossom fragrance, plum blossom, plumeria rubra, frangipani, pointsetia, pomegranate, popcorn, poppy, bougainvillea, powdered, animal, praline, primrose, prune, pumpkin pie, pumpkin, quince, rose, dog rose, red rose, tea rose, white rose, rose geranium, rose hip, plum blossom, prune, pumpkin, plum blossom, pear, plum blossom, pear, plum, pear, plum, and the like, plum, Rose jasmine fragrance, rose musk fragrance, rose oil fragrance, rose petal fragrance, rose raspberry fragrance, rose costustoot fragrance, rosemary mint fragrance, rum fragrance, saffron fragrance, sage fragrance, desert sage fragrance, sandalwood fragrance, vanilla sandalwood fragrance, sassafras fragrance, evening primrose fragrance, sea breeze fragrance, slogan fragrance, sherry wine fragrance, skin care fragrance, cigarette fragrance, soap sandalwood moss fragrance, spearmint fragrance, spice fragrance, christmas fragrance, village fragrance, vanilla fragrance, spice kitchen fragrance, spring flower fragrance, spruce fragrance, stephania japonica fragrance, strawberry cream fragrance, strawberry honey peach fragrance, honey pepper fragrance, honey wine fragrance, honey pepper fragrance, honey peach fragrance, honey pepper fragrance, honey pepper fragrance, honey fragrance, and honey fragrance, and perfume, honey fragrance, and perfume, Sugar cookie aroma, sugar aroma, brown sugar aroma, sunflower aroma, sweet pea aroma, tangerine ginger aroma, white tea ginger aroma, tea aroma, black tea aroma, indian tea aroma, green tea aroma, lemon tea aroma, superior black tea aroma, white tea aroma, teak aroma, tobacco flower aroma, tobacco aroma, toffee aroma, floral water, tomato leaf aroma, tuberose aroma, tulip aroma, passion fruit aroma, vanilla bean aroma, vanilla cream aroma, vanilla aroma, village vanilla aroma, france vanilla aroma, vanilla hazelnut aroma, verbena aroma, vetiver aroma, violet leaf aroma, violet fruit oil aroma, myrobalan aroma, walnut aroma, Watermelon aroma, boy whisky aroma, wine aroma, wintergreen aroma, rattan aroma, witch hazel aroma, costustoot amber aroma, costustoot aroma, costus fruit aroma, herbal aroma, costus musk aroma, costus oriental aroma, costus pink aroma, yew aroma, ylang aroma, grapefruit mint aroma, and mixtures thereof.

The lotion can also include a colorant. For aesthetic purposes, colorants may be used to provide a shade to the lotion prior to the patient applying it to the patient's skin. Alternatively, a colorant may be used to provide color to the lotion prior to the patient applying it to the patient's skin for identification purposes. Alternatively or additionally, a colorant may be used to provide a coloring effect on the skin of the patient after the lotion is applied to the skin of the patient.

The topical composition of the present invention is prepared by sequentially mixing (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent into a skin lotion.

The step of preparing the topical composition of the present invention comprises: a base skin lotion was prepared to which a solid vinylpyrrolidone/vinyl acetate copolymer was added, and then to which a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent was added.

Alternatively, the step of preparing the topical composition of the present invention comprises: a base skin lotion was prepared to which a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent was added, and then a solid vinylpyrrolidone/vinyl acetate copolymer was added thereto.

The term "sequentially" means that the components (a) and (b) are not added simultaneously, but are added one after the other in any suitable order. In one embodiment, ingredient (a) is added first, followed by ingredient (b). In one embodiment, ingredient (b) is added first, followed by ingredient (a).

The present invention also relates to a topical composition for reducing exposure of gaseous contaminants to the skin prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent, wherein the composition is a fully formulated topical lotion for reducing exposure of gaseous contaminants to the skin of a patient.

The term "fully formulated" refers to a lotion that is ready for use by a patient.

In one embodiment, the topical composition of the present invention is used like any common cream, gel or body lotion. The topical composition may be spread on the skin of the patient like any other typical cream, gel, or body wash. Which may be spread by the hand of the patient or any suitable device. The topical composition was spread into a layer of about 20 microns. In another embodiment, the topical composition is spread as a layer of 30 microns or more. In another embodiment, the topical composition is spread as a layer of 15 microns or less. In one embodiment, the topical composition is spread as a layer of 10 to 50 microns.

It has been observed that a solid vinylpyrrolidone/vinyl acetate copolymer (PVP/VA S-630, supplied by Ashland, hereinafter "S-630") having a vinylpyrrolidone to vinyl acetate ratio of 60:40 and an average molecular weight of 51,000 exhibits an ozone block of about 11% at 1.0 wt% addition in the lotion. It has been observed that a vinylpyrrolidone/vinyl acetate copolymer (PVP/VA E-735, supplied by Ashland, hereinafter "E-735") dissolved in pure ethanol at a 50 wt% ratio, with a vinylpyrrolidone to vinyl acetate ratio of 70:30 and an average molecular weight of 56,700, exhibited about 10% ozone blocking at a 1.0 wt% addition in the lotion. However, it has been observed that the addition of both solid vinylpyrrolidone/vinyl acetate copolymer S-630 and dissolved vinylpyrrolidone/vinyl acetate copolymer E-735 at a level of 1% by weight each in the lotion formulation exhibited an ozone block of about 32%. The ozone blocking capacity of lotions comprising solid vinylpyrrolidone/vinyl acetate copolymer and dissolved vinylpyrrolidone/vinyl acetate copolymer is an unusual and unexpectedly large improvement. This large improvement is repeatable and statistically significant.

In one embodiment, the compositions of the present invention reduce ozone transmission by at least 20% compared to compositions without the solid vinylpyrrolidone/vinyl acetate copolymer and the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent. In one embodiment, the compositions of the present invention reduce ozone transmission by at least 20% compared to compositions without the solid vinylpyrrolidone/vinyl acetate copolymer. In one embodiment, the compositions of the present invention reduce ozone transmission by at least 20% compared to compositions without vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent.

The synergistic effect observed in ozone blockade was reproducible and statistically significant. Unfortunately, the theoretical basis for the observed behavior is difficult to find. While lotions containing both S-630 and E-735 exhibited slightly bimodal molecular weight distributions and exhibited slightly different PV: VA ratios, it is more likely to explain the state in which the copolymer was added to the lotion.

The present invention also relates to a method for reducing exposure of gaseous contaminants to the skin of a patient comprising applying to an area of the skin a topical composition prepared by sequentially mixing into a skin lotion (a) a solid vinylpyrrolidone/vinyl acetate copolymer and (b) a vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent. In one embodiment of the process, the copolymer of (a) to (b) is present in a weight ratio of about 8:1 to about 0.4: 1. In one embodiment of the method, the copolymer of (a) and (b) is present in a weight ratio of about 6:1 to about 0.67: 1. In one embodiment of the process, the copolymer of (a) and (b) is present in a weight ratio of about 3:1 to about 1: 1. In one embodiment of the process, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 10,000g/mol to about 100,000 g/mol. In one embodiment of the process, the molecular weight of the solid vinylpyrrolidone/vinyl acetate copolymer is in the range of from about 30,000g/mol to about 70,000 g/mol. In one embodiment of the method, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in the range of from about 10,000g/mol to about 100,000 g/mol. In one embodiment of the method, the molecular weight of the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent is in the range of from about 30,000g/mol to about 70,000 g/mol. In one embodiment of the process, the solvent is selected from the group consisting of alcohols, esters and ketones. In one embodiment of the process, the solvent is selected from the group consisting of ethanol, n-propanol, iso-propanol, methyl acetate, ethyl acetate, methyl propionate, ethyl propionate, acetone, methyl ethyl ketone, and 3-pentanone. In one embodiment of the method, the solvent is ethanol. In one embodiment of the method, the composition further comprises water, a humectant, a preservative, an exfoliating agent, a lubricant, an emollient, and an emulsifier. In one embodiment of the method, the composition is a fully formulated topical lotion for reducing exposure of gaseous contaminants to the skin of a patient. In one embodiment of the method, the 20 micron layer of the composition of the present invention reduces ozone transmission by at least 20% compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer and the vinylpyrrolidone/vinyl acetate copolymer dissolved in a solvent. In one embodiment of the method, the 20 micron layer of the composition of the present invention reduces ozone transmission by at least 20% compared to a composition without the solid vinylpyrrolidone/vinyl acetate copolymer. In one embodiment of the method, the 20 micron layer of the composition of the present invention reduces ozone transmission by at least 20% compared to a composition without the vinylpyrrolidone/vinyl acetate copolymer dissolved in the solvent.

The method comprises the following steps: the topical composition is placed on a small portion of the patient's skin, and the topical composition is spread over a larger area of the patient's skin to form a layer of the topical composition. Alternatively, the method comprises the steps of: the topical composition is placed on the hand of the patient and the topical composition is spread over a larger area of the patient's skin to form a layer of the topical composition. Alternatively, the method comprises the steps of: the topical composition is placed on the device, and the topical composition is spread over a larger area of the patient's skin to form a layer of the topical composition.

The topical composition can be spread on the skin of the patient using the patient's hands or any suitable device. The topical composition was spread into a layer of about 20 microns. In another embodiment, the topical composition is spread as a layer of 30 microns or more. In another embodiment, the topical composition is spread as a layer of 15 microns or less. In one embodiment, the topical composition is spread as a layer of 10 to 50 microns.

The invention also relates to a method of assessing the reduction of the transmission of harmful contaminants to the skin of a patient.

In particular, a method for evaluating the reduction of harmful contaminant transmission to a patient's skin resulting from the use of a research ingredient in a representative topical composition ("lotion") is modeled as the transmission of ozone through the lotion containing the research ingredient to the skin of an animal model.

An ozone decay model is used to determine the ozone blocking performance of the lotion. The purpose of this method is to extract the kinetic rate constant of ozonolysis in the presence of a reactive substrate. The reactive substrate used in the method is animal skin in proximity to human skin. In one embodiment, the method uses 5cm by 5cm pig skin test strips.

The decomposition of ozone in the ozone chamber was modeled by the molar balance:

wherein r is_inFor perfusion rate, r_outTo the outflow rate, r_genTo a rate of production, r_conspnIs the ozone depletion rate.

Since the method only focuses on the decay curve of ozone, the ozone generator is turned off once the concentration of ozone in the chamber reaches 800 ppb. Therefore, the first 3 terms in the equation can be ignored. Equation (1) then becomes:

the ozone depletion is determined by the decomposition rate r_decompAnd reaction rate r_rxnAnd (4) explanation. Decomposition rate r_decompFor background decomposition of ozone, this is the characteristic decomposition of the chamber by the catalyst of the carilite particles in the absence of reactive substrates. Reaction rate r_rxnOzone is consumed by reaction with a reactive substrate. Equation (2) can be further broken down in terms of concentration.

Wherein [ O ]₃]Is the concentration of ozone, [ s ]]Is the concentration of reactive species in the pigskin, k_dThe ozone background decomposition rate constant, k, characteristic of the chamber_rxnα, β, and γ are their respective reaction orders for the rate constant of ozone depletion by reaction with the reactive substrate.

To determine the reaction order α, the background decomposition of ozone in the chamber in the absence of reactive substrate was measured and the regression of equation (5) was performed.

In some embodiments, ln (d [ O ]) in the absence of a reactive substrate₃]Dt) vs. ln [ O ]₃]The regression of (a) is linear, indicating the first order reaction rate, so α is 1.

To determine the reaction order γ, O in the presence of a reactive substrate is measured₃Concentration profile. A regression analysis similar to that described above was performed as shown in equation (6).

In some embodiments, ln (-d [ O ]) is in the presence of a reactive substrate₃]Dt) vs. ln [ O ]₃]Generates a straight line indicating O₃The total number of decomposition stages in terms of concentration is equal to 1. In such embodiments, it can be concluded that γ ═ 1 and the rate of ozone decomposition does not depend on the concentration of reactive species in the substrate. This may be explained by the effective concentration of reactive species on the pig skin [ s]Much greater than the concentration of ozone. In such embodiments, the ozone concentration is rate controlled, not the concentration of the reactive species [ s ]]. Equation (3) can be simplified as:

the peer-to-peer two-sided integration yields:

in some embodiments, the model is simplified to equation (11). K can be determined by direct regression of the concentration curve from the experiment into the equation_app. Reaction rate constant k_appIs the ozone background decomposition rate constant k characteristic of the chamber_dAnd hypothesis [ s ]]Rate constant k for depletion of ozone by reaction with a reactive substrate when not rate limiting_rxnA combination of 'or' and.

The above model can be used to evaluate the efficacy of blocking the transmission of harmful contaminants. In one embodiment, the procedure for evaluating the blocking effect of various ingredients in a lotion can be performed in a series of steps, including: (a) preparing a lotion; (b) loading a lotion formulation onto a test strip model of human skin; (c) exposing the loaded coupon to an ozone-rich atmosphere; (d) ozone transmission through the lotion was calculated.

Examples

The above model was used to evaluate ozone blocking efficacy in a basic topical composition. The base topical composition is a commercially available body lotion.

Example 1

Three experimental batches of lotion were prepared. In a first batch, 1.0 wt% of a solid vinylpyrrolidone/vinyl acetate copolymer was mixed into a base topical composition, wherein the vinylpyrrolidone: vinyl acetate ratio was 60:40 and the average molecular weight was 51,000(PVP/VA S-630, supplied by Ashland, hereinafter "S-630"). In a second batch, 1.0 wt% of a vinylpyrrolidone/vinyl acetate copolymer dissolved in pure ethanol at a 50 wt% ratio, wherein the vinylpyrrolidone to vinyl acetate ratio is 70:30, and the average molecular weight is 56,700(PVP/VA E-735, supplied by Ashland, hereinafter "E-735"), was mixed into the base topical composition. In a third batch, 1.0 wt% S-630 and 1.0 wt% E-735 were mixed sequentially into the base topical composition.

For each test, a 5 x 5cm pig skin test piece (Animals Technology, Inc. (boltzmann, maryland, usa)) was loaded with about 50mg of the formulated lotion in the middle and spread over the entire surface of the test piece using the index finger. This procedure coated the entire surface of the test piece with a layer of lotion of about 20 μm.

The loaded coupons were then incubated at 37 ℃ for 30 minutes to allow water to evaporate from the lotion. Such incubation mimics the typical condition of a lotion as used by a patient.

The loaded test strip was placed into an ozone chamber (Oxidation Technologies, LLC. (infix, indiana) and the atmospheric ozone level in the chamber was increased to over 800 ppb. An ozone level of 800ppb is a typical high tropospheric ozone level observed in heavily polluted cities in the hot summer months.

Once the ozone concentration exceeds 800ppb, the introduction or generation of ozone in the chamber is stopped and the ozone level is allowed to decay. Once the ozone concentration had dropped to 800ppb, a stopwatch was started. The concentration is then recorded every 30 seconds for 10 minutes or more.

The above procedure was repeated three or four times for each of the three lotions. The% ozone blocked by the use of the lotion was then calculated using the above model. The results are presented in the table below.

TABLE 1

The data described in table 1 (above) demonstrate that the use of E-735 and S-630 alone in the base lotion had a small but still statistically significant effect on ozone blocking. The data in table 1 (above) also shows that the combined use of E-735 and S-630 in the base lotion has a surprisingly significant effect on the ozone blocking effect of the lotion.

Example 2

Three additional experimental batches of lotion were prepared. In the fourth batch, 0.75 wt% S-630 and 0.75 wt% E-735 were mixed sequentially into the base topical composition. In a fifth batch, 1.5 wt% S-630 and 0.5 wt% E-735 were mixed sequentially into the base topical composition. In a sixth batch, 0.5 wt% S-630 and 1.5 wt% E-735 were mixed sequentially into the base topical composition.

These batches were then applied to swine coupons, incubated and treated in an ozone chamber in a similar manner as described above.

The% ozone blocked by the use of the lotion was then calculated using the above model. The results for the third to sixth batches are presented in the table below.

TABLE 2

The data described in table 2 demonstrates the surprising effect on ozone blocking by varying the ratio of solid PVP/VA copolymer to dissolved PVP/VA copolymer.

Example 3

Additional experiments were conducted for various combinations of polymers as described in examples 1 and 2 above. These experiments involved PVP/VA copolymer alone and the following polymer combinations:

combination 1: 1% PVP/VA copolymer (Plasdone)^TMS-630) + 1% of VP/eicosene copolymer (Unimer U-15)

Combination 2: 1% PVP/VA copolymer (Plasdone)^TMS-630) + 1% of a VP/hexadecene copolymer and octyldodecanol mixture (Unimer U-1946)

Combination 3: 1% PVP/VA copolymer (Plasdone)^TMS-630) + 1% of acrylic polymer (Noverite)^TMK-752)

Combination 4: 1% PVP/VA copolymer (Plasdone)^TMS-630) + 1% myristamidopropyl PG-dimethylammonium chloride phosphate (Arlasilk)^TMPTM)

Combination 5: 1% PVP/VA copolymer (Plasdone)^TMS-630) + 1% of an acrylate copolymerAQF

The results of these experiments are described in table 3 (below).

TABLE 3

The data described in table 3 (above) highlights the surprising results provided by the inventive polymer combination of the present invention.

While the present invention has been described in connection with several embodiments, and these embodiments have been set forth in considerable detail for the purpose of complete disclosure of the invention, such embodiments are merely exemplary and are not intended to limit or represent an exhaustive enumeration of all aspects of the invention. The scope of the invention is to be determined by the claims appended hereto. In addition, it will be apparent to those skilled in the art that many changes in such details may be made without departing from the spirit and principles of the invention.