阅读说明：本技术 亲水性聚氨酯敷料及其制备方法 (Hydrophilic polyurethane dressing and preparation method thereof ) 是由 樊李红 魏浩杰 谢益思 刘爽 周小虎 于 2021-09-09 设计创作，主要内容包括：本发明公开了一种亲水性聚氨酯敷料及其制备方法,它的原料包括100份的聚醚多元醇、0.1-0.5份的胺类催化剂、0.1-0.7份的锌类催化剂、1.2-3.5份的有机硅匀泡剂、1-6份的水、1-15份的发泡剂、1-10份的海藻酸钠、1-10份的透明质酸、1-10份的壳聚糖和35-65份的二苯基甲烷二异氰酸酯。将聚醚多元醇、胺类催化剂、锌类催化剂、有机硅匀泡剂、水、发泡剂、海藻酸钠、透明质酸和壳聚糖机械搅拌混合均匀；将二苯基甲烷二异氰酸酯倒入白料,机械搅拌混合均匀,倒入模具发泡,熟化,脱模。该敷料具有多孔结构,对液体有较大的吸收容量,保温,吸水,保湿能力较强的特点,其提供有利于伤口愈合的微环境。(The invention discloses a hydrophilic polyurethane dressing and a preparation method thereof, and raw materials of the dressing comprise 100 parts of polyether polyol, 0.1-0.5 part of amine catalyst, 0.1-0.7 part of zinc catalyst, 1.2-3.5 parts of organosilicon foam stabilizer, 1-6 parts of water, 1-15 parts of foaming agent, 1-10 parts of sodium alginate, 1-10 parts of hyaluronic acid, 1-10 parts of chitosan and 35-65 parts of diphenylmethane diisocyanate. Mechanically stirring and uniformly mixing polyether polyol, an amine catalyst, a zinc catalyst, an organic silicon foam stabilizer, water, a foaming agent, sodium alginate, hyaluronic acid and chitosan; pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing and demolding. The dressing has a porous structure, has the characteristics of large absorption capacity on liquid, and strong heat preservation, water absorption and moisture preservation capabilities, and provides a microenvironment beneficial to wound healing.)

1. A hydrophilic polyurethane dressing is characterized in that: the hydrophilic polyurethane dressing comprises, by weight, 100 parts of polyether polyol, 0.1-0.5 part of amine catalyst, 0.1-0.7 part of zinc catalyst, 1.2-3.5 parts of organic silicon foam stabilizer, 1-6 parts of water, 1-15 parts of foaming agent, 1-10 parts of sodium alginate, 1-10 parts of hyaluronic acid, 1-10 parts of chitosan and 35-65 parts of diphenylmethane diisocyanate.

2. The hydrophilic polyurethane dressing of claim 1, wherein: the hydrophilic polyurethane dressing comprises, by weight, 100 parts of polyether polyol, 0.1-0.3 part of amine catalyst, 0.1-0.5 part of zinc catalyst, 1.2-2.5 parts of organic silicon foam stabilizer, 1-3 parts of water, 6-12 parts of foaming agent, 1-10 parts of sodium alginate, 1-10 parts of hyaluronic acid, 1-10 parts of chitosan and 35-50 parts of diphenylmethane diisocyanate.

3. The hydrophilic polyurethane dressing of claim 1 or 2, wherein: the hydroxyl value of the polyether polyol is 60-120 mg KOH/g, and the molecular weight is 2800-5500.

4. The hydrophilic polyurethane dressing of claim 1 or 2, wherein: the foaming agent is dichloromethane or cyclopentane.

5. The hydrophilic polyurethane dressing of claim 1 or 2, wherein: the amine catalyst is one or more of triethylene diamine, ethylene diamine, triethylamine, triethanolamine and hexamethylene diamine.

6. The hydrophilic polyurethane dressing of claim 1 or 2, wherein: the hydrophilic polyurethane dressing comprises, by weight, 63mg KOH/g of hydroxyl value, 30 parts of polyether polyol with the molecular weight of 5100, 87mg KOH/g of hydroxyl value, 30 parts of polyether polyol with the molecular weight of 3400, 112mg KOH/g of hydroxyl value, 40 parts of polyether polyol with the molecular weight of 2800, 0.2 part of triethylene diamine, 0.3 part of zinc catalyst, 1.5 parts of organosilicon foam stabilizer, 1.5 parts of water, 10 parts of cyclopentane, 6 parts of sodium alginate, 4 parts of hyaluronic acid, 8 parts of chitosan and 40 parts of diphenylmethane diisocyanate.

7. A method for preparing the hydrophilic polyurethane dressing of claim 1, which is characterized in that: the method comprises the following steps:

1) the foaming agent comprises, by weight, 100 parts of polyether polyol, 0.1-0.5 part of amine catalyst, 0.1-0.7 part of zinc catalyst, 1.2-3.5 parts of organosilicon foam stabilizer, 1-6 parts of water, 1-15 parts of foaming agent, 1-10 parts of sodium alginate, 1-10 parts of hyaluronic acid, 1-10 parts of chitosan and 35-65 parts of diphenylmethane diisocyanate for later use;

2) mechanically stirring and uniformly mixing polyether polyol, an amine catalyst, a zinc catalyst, an organic silicon foam stabilizer, water, a foaming agent, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (2) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing.

Technical Field

The invention relates to the field of medical materials, in particular to a hydrophilic polyurethane dressing and a preparation method thereof.

Background

The development of science and technology continuously improves the requirements of people on medical dressings, traditional dressings such as gauze and cotton are easy to breed bacteria, wound exudate and dry dermal tissues are easy to form crusts together to prevent epithelialization, the wound is easy to adhere to the dressings, and secondary wound is brought to patients when dressing change is uncovered, so that the novel wound dressing has great significance.

Because the polyurethane material has the advantages of excellent biological safety, no distortion effect, no anaphylactic reaction, excellent anticoagulation performance, medical requirement compliance of toxicity test, excellent toughness and elasticity, good processing performance, various processing modes and the like, the polyurethane material is widely applied to wound dressings in the modes of films, hydrogels, foams and the like.

Polyurethane sponges are generally not hydrophilic or even hydrophobic due to the nature of polyether polyols, and to modify this, it is generally possible to add hydrophilic aids and use modified polyols. Medical dressings have a risk of contacting blood and body fluids, so that the safety requirements for dissolution of the hydrophilic auxiliary are high, and the water absorption rate is also certain. At present, most of polyurethane dressings in the market use modified polyether, and natural polymer hydrophilic auxiliary agents are rarely used, so that the market has certain blank.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a hydrophilic polyurethane dressing and a preparation method thereof, wherein the dressing has a porous structure, has the characteristics of large liquid absorption capacity, heat preservation, water absorption and strong moisture retention capacity, and provides a microenvironment beneficial to wound healing; in addition, the dressing has soft texture, and is comfortable for patients to use.

In order to achieve the purpose, the hydrophilic polyurethane dressing comprises the following raw materials, by weight, 100 parts of polyether polyol, 0.1-0.5 part of amine catalyst, 0.1-0.7 part of zinc catalyst, 1.2-3.5 parts of organic silicon foam stabilizer, 1-6 parts of water, 1-15 parts of foaming agent, 1-10 parts of sodium alginate, 1-10 parts of hyaluronic acid, 1-10 parts of chitosan and 35-65 parts of diphenylmethane diisocyanate.

Further, the hydrophilic polyurethane dressing comprises, by weight, 100 parts of polyether polyol, 0.1-0.3 part of amine catalyst, 0.1-0.5 part of zinc catalyst, 1.2-2.5 parts of organosilicon foam stabilizer, 1-3 parts of water, 6-12 parts of foaming agent, 1-10 parts of sodium alginate, 1-10 parts of hyaluronic acid, 1-10 parts of chitosan and 35-50 parts of diphenylmethane diisocyanate.

Further, the hydroxyl value of the polyether polyol is 60-120 mg KOH/g, and the molecular weight is 2800-5500.

Still further, the blowing agent is dichloromethane or cyclopentane.

Still further, the amine catalyst may be any one or more of triethylene diamine, ethylene diamine, triethylamine, triethanolamine and hexamethylene diamine.

Still further, the raw materials of the hydrophilic polyurethane dressing comprise, by weight, 63mg KOH/g of polyether polyol with the molecular weight of 5100, 30 parts of polyether polyol with the hydroxyl value of 87mg KOH/g and the molecular weight of 3400, 40 parts of polyether polyol with the hydroxyl value of 112mg KOH/g and the molecular weight of 2800, 0.2 part of triethylene diamine, 0.3 part of zinc catalyst, 1.5 parts of organosilicon foam stabilizer, 1.5 parts of water, 10 parts of cyclopentane, 6 parts of sodium alginate, 4 parts of hyaluronic acid, 8 parts of chitosan and 40 parts of diphenylmethane diisocyanate.

The invention also provides a preparation method of the hydrophilic polyurethane dressing, which comprises the following steps:

1) the foaming agent comprises, by weight, 100 parts of polyether polyol, 0.1-0.5 part of amine catalyst, 0.1-0.7 part of zinc catalyst, 1.2-3.5 parts of organosilicon foam stabilizer, 1-6 parts of water, 1-15 parts of foaming agent, 1-10 parts of sodium alginate, 1-10 parts of hyaluronic acid, 1-10 parts of chitosan and 35-65 parts of diphenylmethane diisocyanate for later use;

2) mechanically stirring and uniformly mixing polyether polyol, an amine catalyst, a zinc catalyst, an organic silicon foam stabilizer, water, a foaming agent, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (2) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing.

The invention has the beneficial effects that:

(1) the invention selects and compounds a plurality of polyether polyols, so that the polyurethane dressing has better hydrophilicity

(2) The gel catalyst used in the invention replaces the conventional tin catalyst, and is safe and nontoxic

(3) The moisture-absorbing and moisture-preserving performance of the dressing is enhanced by adding the humectant.

Detailed Description

The present invention is described in further detail below with reference to specific examples so as to be understood by those skilled in the art.

Example 1

The preparation method of the hydrophilic polyurethane dressing 1 comprises the following steps:

1) weighing 50 parts of polyether polyol with the hydroxyl value of 63mg KOH/g and the molecular weight of 5100, 50 parts of polyether polyol with the hydroxyl value of 87mg KOH/g and the molecular weight of 3400, 0.4 part of triethylene diamine, 0.5 part of zinc catalyst, 2.5 parts of organic silicon foam stabilizer, 5 parts of water, 10 parts of cyclopentane and 55 parts of diphenylmethane diisocyanate according to the parts by weight for later use;

2) mechanically stirring and uniformly mixing polyether polyol, triethylene diamine, a zinc catalyst, an organic silicon foam stabilizer, water, triethylene diamine, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (2) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing 1.

Example 2

The preparation method of the hydrophilic polyurethane dressing 2 comprises the following steps:

1) weighing 30 parts of polyether polyol with the hydroxyl value of 63mg KOH/g and the molecular weight of 5100, 70 parts of polyether polyol with the hydroxyl value of 87mg KOH/g and the molecular weight of 3400, 0.2 part of hexamethylenediamine agent, 0.4 part of zinc catalyst, 2 parts of organic silicon foam stabilizer, 5 parts of water, 8 parts of dichloromethane, 8 parts of sodium alginate, 8 parts of hyaluronic acid, 6 parts of chitosan and 55 parts of diphenylmethane diisocyanate according to the parts by weight for later use;

2) mechanically stirring and uniformly mixing polyether polyol, a hexamethylene diamine agent, a zinc catalyst, an organic silicon foam stabilizer, water, dichloromethane, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (2) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing 2.

Example 3

The preparation method of the hydrophilic polyurethane dressing 3 comprises the following steps:

1) weighing 50 parts of polyether polyol with the hydroxyl value of 63mg KOH/g and the molecular weight of 5100, 50 parts of polyether polyol with the hydroxyl value of 112mg KOH/g and the molecular weight of 2800, 0.3 part of ethylenediamine, 0.2 part of zinc catalyst, 1.5 parts of organic silicon foam stabilizer, 5 parts of water, 10 parts of cyclopentane, 8 parts of sodium alginate, 4 parts of hyaluronic acid, 5 parts of chitosan and 45 parts of diphenylmethane diisocyanate according to the parts by weight for later use;

2) mechanically stirring and uniformly mixing polyether polyol, ethylenediamine, a zinc catalyst, an organic silicon foam stabilizer, water, cyclopentane, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (2) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing 3.

Example 4

The preparation method of the hydrophilic polyurethane dressing 4 comprises the following steps:

1) weighing 30 parts of polyether polyol with the hydroxyl value of 63mg KOH/g and the molecular weight of 5100, 70 parts of polyether polyol with the hydroxyl value of 112mg KOH/g and the molecular weight of 2800, 0.3 part of triethanolamine, 0.4 part of zinc catalyst, 1.5 parts of organic silicon foam stabilizer, 3.5 parts of water, 10 parts of dichloromethane, 6 parts of sodium alginate, 3 parts of hyaluronic acid, 5 parts of chitosan and 55 parts of diphenylmethane diisocyanate according to the parts by weight for later use;

2) mechanically stirring and uniformly mixing polyether polyol, triethanolamine, a zinc catalyst, an organic silicon foam stabilizer, water, dichloromethane, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (2) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing 4.

Example 5

The preparation method of the hydrophilic polyurethane dressing 5 comprises the following steps:

1) weighing 50 parts of polyether polyol with the hydroxyl value of 87mg KOH/g and the molecular weight of 3400, 50 parts of polyether polyol with the hydroxyl value of 112mg KOH/g and the molecular weight of 2800, 0.3 part of triethylamine, 0.2 part of zinc catalyst, 2.5 parts of organic silicon foam stabilizer, 2.5 parts of water, 15 parts of dichloromethane, 8 parts of sodium alginate, 8 parts of hyaluronic acid, 6 parts of chitosan and 40 parts of diphenylmethane diisocyanate according to the parts by weight for later use;

2) mechanically stirring and uniformly mixing polyether polyol, triethylamine, a zinc catalyst, an organic silicon foam stabilizer, water, dichloromethane, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (2) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing 5.

Example 6

The preparation method of the hydrophilic polyurethane dressing 6 comprises the following steps:

1) weighing 30 parts of polyether polyol with the hydroxyl value of 63mg KOH/g and the molecular weight of 5100, 30 parts of polyether polyol with the hydroxyl value of 87mg KOH/g and the molecular weight of 3400, 40 parts of polyether polyol with the hydroxyl value of 112mg KOH/g and the molecular weight of 2800, 0.2 part of triethylene diamine, 0.3 part of zinc catalyst, 1.5 parts of organic silicon foam stabilizer, 1.5 parts of water, 10 parts of cyclopentane, 6 parts of sodium alginate, 4 parts of hyaluronic acid, 8 parts of chitosan and 40 parts of diphenylmethane diisocyanate according to the weight parts ratio for later use;

2) mechanically stirring and uniformly mixing polyether polyol, triethylene diamine, a zinc catalyst, an organic silicon foam stabilizer, water, cyclopentane, sodium alginate, hyaluronic acid and chitosan to obtain a white material;

3) and (3) pouring the diphenylmethane diisocyanate into the white material, mechanically stirring and uniformly mixing, pouring into a mold for foaming, curing at 80 ℃ for 24 hours, and demolding to obtain the hydrophilic polyurethane dressing 6.

The antibacterial property, the cytotoxicity and the aperture ratio of the hydrophilic polyurethane dressings 1 to 6 prepared in examples 1 to 6 were tested:

1. water absorption and retention Performance test

2. Cytotoxicity test

3. Antibacterial property test

Compared with the existing products sold in the market, the hydrophilic polyurethane dressings 1 to 6 prepared in the embodiments 1 to 6 have various performances obviously superior to those of the products sold in the market, wherein the hydrophilic polyurethane dressing 6 has the best effect.

Other parts not described in detail are prior art. Although the present invention has been described in detail with reference to the above embodiments, it is only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and the embodiments are within the scope of the present invention.