阅读说明：本技术 一种抗菌高粘合医用胶水及其制备方法 (Antibacterial high-adhesion medical glue and preparation method thereof ) 是由 秦晓鹏 魏先锋 于 2021-09-08 设计创作，主要内容包括：本发明公开一种抗菌高粘合医用胶水,由以下比例重量的材料组成：a－氰基丙烯酸酯40-56份；芦荟胶30-45份；仙人掌果实萃取物20-30份；艾草提取液40-55份；增塑剂5-10份；增粘剂10-15份；稳定剂7-10份；血纤蛋白原15-20份；凝血酶8-15份；血液凝固第Ⅷ因子3-8份；抑肽酶1-3份；薄荷醇5-15份；天然橡胶30-42份和丙烯酸共聚物10-23份。本发明中添加凝血酶、血液凝固第Ⅷ因子和抑肽酶,粘合并不受血小板减少等血液凝固障碍的影响,并较为迅速,不需过高的热或压力,不受粘合部位水分影响,生物相容性好,可适度吸收,同时添加有芦荟胶和艾草提取液,对多种致病真菌也有一定的抑制作用,消炎、杀菌、镇痛、吸热消肿、软化皮肤、止痛,有改善伤痕的作用,通过添加薄荷醇可以清凉止痛。(The invention discloses an antibacterial high-adhesion medical glue which is prepared from the following materials in parts by weight: 40-56 parts of a-cyanoacrylate; 30-45 parts of aloe gel; 20-30 parts of cactus fruit extract; 40-55 parts of wormwood extracting solution; 5-10 parts of a plasticizer; 10-15 parts of a tackifier; 7-10 parts of a stabilizer; 15-20 parts of fibrinogen; 8-15 parts of thrombin; 3-8 parts of blood coagulation factor VIII; 1-3 parts of aprotinin; 5-15 parts of menthol; 30-42 parts of natural rubber and 10-23 parts of acrylic copolymer. The invention adds thrombin, blood coagulation factor VIII and aprotinin, the adhesion is not influenced by blood coagulation disorder such as thrombocytopenia, the adhesion is quicker, excessive heat or pressure is not needed, the adhesion is not influenced by water at the adhesion part, the biocompatibility is good, the adhesion can be properly absorbed, simultaneously, the aloe gel and the wormwood extract are added, the aloe gel and the wormwood extract have certain inhibition effect on various pathogenic fungi, and the functions of diminishing inflammation, sterilizing, easing pain, absorbing heat and reducing swelling, softening skin and relieving pain and improving scars can be realized, and the cooling and the pain relieving can be realized by adding menthol.)

1. The antibacterial high-adhesion medical glue is characterized in that: the material composition comprises the following materials in percentage by weight: 40-56 parts of a-cyanoacrylate; 30-45 parts of aloe gel; 20-30 parts of cactus fruit extract; 40-55 parts of wormwood extracting solution; 5-10 parts of a plasticizer; 10-15 parts of a tackifier; 7-10 parts of a stabilizer; 15-20 parts of fibrinogen; 8-15 parts of thrombin; 3-8 parts of blood coagulation factor VIII; 1-3 parts of aprotinin; 5-15 parts of menthol; 30-42 parts of natural rubber and 10-23 parts of acrylic copolymer.

2. The antibacterial high-adhesion medical glue and the preparation method thereof as claimed in claim 1, are characterized in that: the production process of the antibacterial high-adhesion medical glue comprises the following steps: s1, pretreatment of prepared materials, S2, preparation of raw materials, S3, adding and mixing, S4, stirring initiation and S5, and quantitative packaging, wherein:

s1, pretreatment of prepared materials: selecting the following materials in proportion by weight: 40-56 parts of a-cyanoacrylate; 5-10 parts of a plasticizer; 10-15 parts of a tackifier; 7-10 parts of a stabilizer; 15-20 parts of fibrinogen; 8-15 parts of thrombin; 3-8 parts of blood coagulation factor VIII; 1-3 parts of aprotinin; 5-15 parts of menthol; 30-42 parts of natural rubber and 10-23 parts of acrylic copolymer;

s2, preparation of raw materials: the method comprises the following steps of a, preparing aloe gel, b, extracting cactus fruit extract, c, extracting wormwood liquid, wherein:

a. preparing aloe gel: selecting high-quality and quantitative aloe leaves, cleaning, peeling, crushing and homogenizing the aloe leaves to obtain aloe raw juice, centrifuging to obtain aloe raw juice, removing anthraquinone by using adsorption resin, removing calcium and magnesium by using ion exchange resin, mixing with carbomer ionized water, stirring and sterilizing;

b. extracting cactus fruit extract: selecting fresh cactus fruits, cleaning, peeling and crushing aloe leaves, homogenizing to obtain slurry, centrifuging to obtain stock solution, removing calcium and magnesium from the obtained stock solution by using ion exchange resin, and then distilling and extracting;

c. extracting wormwood liquid: selecting fresh folium Artemisiae Argyi, cleaning, crushing, mixing with water, homogenizing to obtain slurry, centrifuging to obtain stock solution, and concentrating by distillation;

s3, adding and mixing: s1, mixing the raw materials selected in the preparation pretreatment, and then extracting the aloe gel obtained in the step a, the extract obtained in the step b and the cactus fruit extract, and the wormwood liquid obtained in the step c;

s4, stirring and initiating: introducing the mixed solution prepared by adding and mixing in the step S3 into a stirring device for uniform stirring, adding an initiator during stirring, and adopting a mode of dropwise adding at an upper uniform speed and dropwise adding at a lower uniform speed when adding the initiator, wherein the stirring time is 20-30 min;

s5, quantitative packaging: and D, quantitatively packaging the glue obtained by stirring in the step S4 after vacuum sterilization.

3. The antibacterial high-adhesion medical glue and the preparation method thereof according to claim 2 are characterized in that: in the step S1 of the preparation process, the plasticizer in the pretreatment of the preparation is higher polyol ester (such as dioctyl sebacate) and the tackifier is soluble polymer (such as polymethacrylate) and the stabilizer is hydroquinone and sulfur dioxide.

4. The antibacterial high-adhesion medical glue and the preparation method thereof according to claim 2 are characterized in that: in the step S1 of the preparation process, the menthol needs to be purified in the pretreatment of the prepared material, firstly, quantitative crude menthol is weighed, and the crude menthol is dissolved in a nitrile solvent and then is concentrated and crystallized by distillation.

5. The antibacterial high-adhesion medical glue and the preparation method thereof according to claim 2 are characterized in that: the preparation process comprises the step a, in the preparation of the aloe gel, carbomer ionic water is ionic water and carbomer is swelled for 12 to 14 hours.

6. The antibacterial high-adhesion medical glue and the preparation method thereof according to claim 2 are characterized in that: the preparation process comprises the step b, the cactus fruit extract is extracted, and the step c, the wormwood liquid are extracted to prepare the stock solution, and then the stock solution is subjected to vacuum sterilization treatment.

7. The antibacterial high-adhesion medical glue and the preparation method thereof according to claim 2 are characterized in that: the preparation process comprises the step b of extracting the cactus fruit extract and the step c of distilling the wormwood liquid, wherein the distillation temperature is between 70 and 85 ℃, and the cactus fruit extract and the wormwood liquid are stirred at a constant speed in the distillation process.

8. The antibacterial high-adhesion medical glue and the preparation method thereof according to claim 2 are characterized in that: in the step S4 of the preparation process, a steam heating mode is adopted for heat preservation when the initiator is dripped and stirred in stirring initiation, and the heating temperature is 40 ℃ to 60 ℃.

9. The antibacterial high-adhesion medical glue and the preparation method thereof according to claim 2 are characterized in that: the preparation process comprises the step S5, wherein the packaging quality in quantitative packaging is 50ML, 100 ML and 150ML, and the packaging is carried out in a vacuum packaging mode.

Technical Field

The invention relates to the technical field of medical glue, in particular to antibacterial high-adhesion medical glue and a preparation method thereof.

Background

The medical glue is a new medical product for replacing a suture needle, the main component of the medical glue is a-cyanoacrylate, the polymerization speed of organism tissues is fastest, the medical glue can be rapidly polymerized, solidified and formed into a film under the action of anions in wound blood and tissue fluid, the medical glue is tightly embedded with the wound, the involution state of the wound can be firmly kept, the glue film can prevent blood cells and blood platelets from passing through, the small blood vessels broken on the wound can be effectively stopped bleeding under the combined action of thrombin and fibrinogen, meanwhile, the glue film can isolate tissues and bacteria, the medical glue has the functions of resisting infection and protecting the wound, and an ether chain in a polymer also has the function of relieving pain.

The prior pressure-sensitive adhesive has the following defects:

although the medical glue is convenient to use, the impact resistance is poor, the degradation speed is slow, and the bonding force strength is not enough.

Disclosure of Invention

The invention aims to provide an antibacterial high-adhesion medical glue and a preparation method thereof, and aims to solve the problems in the background art.

An antibacterial high-adhesion medical glue is composed of the following materials in parts by weight: 40-56 parts of a-cyanoacrylate; 30-45 parts of aloe gel; 20-30 parts of cactus fruit extract; 40-55 parts of wormwood extracting solution; 5-10 parts of a plasticizer; 10-15 parts of a tackifier; 7-10 parts of a stabilizer; 15-20 parts of fibrinogen; 8-15 parts of thrombin; 3-8 parts of blood coagulation factor VIII; 1-3 parts of aprotinin; 5-15 parts of menthol; 30-42 parts of natural rubber and 10-23 parts of acrylic copolymer.

The invention also provides the antibacterial high-adhesion medical glue and a preparation method thereof, and the production process of the antibacterial high-adhesion medical glue comprises the following steps: s1, pretreatment of prepared materials, S2, preparation of raw materials, S3, adding and mixing, S4, stirring initiation and S5, and quantitative packaging, wherein:

s1, pretreatment of prepared materials: selecting the following materials in proportion by weight: 40-56 parts of a-cyanoacrylate; 5-10 parts of a plasticizer; 10-15 parts of a tackifier; 7-10 parts of a stabilizer; 15-20 parts of fibrinogen; 8-15 parts of thrombin; 3-8 parts of blood coagulation factor VIII; 1-3 parts of aprotinin; 5-15 parts of menthol; 30-42 parts of natural rubber and 10-23 parts of acrylic copolymer;

s2, preparation of raw materials: the method comprises the following steps of a, preparing aloe gel, b, extracting cactus fruit extract, c, extracting wormwood liquid, wherein:

a. preparing aloe gel: selecting high-quality and quantitative aloe leaves, cleaning, peeling, crushing and homogenizing the aloe leaves to obtain aloe raw juice, centrifuging to obtain aloe raw juice, removing anthraquinone by using adsorption resin, removing calcium and magnesium by using ion exchange resin, mixing with carbomer ionized water, stirring and sterilizing;

b. extracting cactus fruit extract: selecting fresh cactus fruits, cleaning, peeling and crushing aloe leaves, homogenizing to obtain slurry, centrifuging to obtain stock solution, removing calcium and magnesium from the obtained stock solution by using ion exchange resin, and then distilling and extracting;

c. extracting wormwood liquid: selecting fresh folium Artemisiae Argyi, cleaning, crushing, mixing with water, homogenizing to obtain slurry, centrifuging to obtain stock solution, and concentrating by distillation;

s3, adding and mixing: s1, mixing the raw materials selected in the preparation pretreatment, and then extracting the aloe gel obtained in the step a, the extract obtained in the step b and the cactus fruit extract, and the wormwood liquid obtained in the step c;

s4, stirring and initiating: introducing the mixed solution prepared by adding and mixing in the step S3 into a stirring device for uniform stirring, adding an initiator during stirring, and adopting a mode of dropwise adding at an upper uniform speed and dropwise adding at a lower uniform speed when adding the initiator, wherein the stirring time is 20-30 min;

s5, quantitative packaging: and D, quantitatively packaging the glue obtained by stirring in the step S4 after vacuum sterilization.

As a further improvement of the invention, in the step S1 of the preparation process, the plasticizer in the pretreatment of the stock is higher polyol ester (such as dioctyl sebacate) and the like, the tackifier is soluble polymer (such as polymethacrylate) and the stabilizer is hydroquinone and sulfur dioxide.

As a further improvement of the invention, in the step S1 of the preparation process, the menthol needs to be purified in the pretreatment of the stock preparation, a certain amount of crude menthol is weighed, and the crude menthol is dissolved in a nitrile solvent and then is concentrated and crystallized by distillation.

As a further improvement of the invention, the preparation process step a, the preparation of the aloe gel, wherein the carbomer ionic water is ionic water and carbomer is swelled for 12 to 14 hours.

As a further improvement of the invention, the preparation process comprises the steps of b, extracting the cactus fruit extract and c, extracting the wormwood liquid, and performing vacuum sterilization treatment after the raw liquid is prepared.

As a further improvement of the invention, in the step b of the preparation process, the cactus fruit extract is extracted, and the distillation temperature in the step c of the wormwood liquid extraction is between 70 and 85 ℃, and the cactus fruit extract and the wormwood liquid are stirred at a constant speed in the distillation process.

As a further improvement of the invention, in the step S4 of the preparation process, steam heating is adopted for heat preservation during stirring by dripping the initiator during stirring initiation, and the heating temperature is 40-60 ℃.

As a further improvement of the invention, the preparation process step S5 includes three packaging qualities of 50ML, 100 ML and 150ML in quantitative packaging, and the packaging is carried out in a vacuum packaging mode.

Compared with the prior art, the invention has the beneficial effects that:

1. by adding thrombin, blood coagulation factor VIII and aprotinin, the adhesion is not influenced by blood coagulation obstacles such as thrombocytopenia and the like, is quicker, does not need overhigh heat or pressure, is not influenced by water at the adhesion part, has good biocompatibility and can be properly absorbed;

2. according to the invention, the aloe gel and the wormwood extracting solution are added, the wormwood extracting solution also has a certain inhibiting effect on various pathogenic fungi, the aloe gel can diminish inflammation, sterilize, ease pain, absorb heat to reduce swelling, soften skin, relieve pain and improve the effect of scars, and the adhesion effect can be increased through the viscosity of the aloe gel;

3. the invention can cool and relieve pain, preserve and sterilize by adding menthol, and can accelerate wound healing and promote skin cell regeneration by adding the cactus fruit extract.

Drawings

FIG. 1 is a flow chart of an antibacterial high-adhesion medical glue and a preparation method thereof;

FIG. 2 is a flow chart of the preparation method S2 of the antibacterial high-adhesion medical glue and the raw materials thereof.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

Referring to fig. 1-2, the present invention provides the following technical solutions: an antibacterial high-adhesion medical glue is composed of the following materials in parts by weight: 45 parts of a-cyanoacrylate; 35 parts of aloe gel; 22 parts of cactus fruit extract; 40 parts of wormwood extracting solution; 5 parts of a plasticizer; 6 parts of a tackifier; 7 parts of a stabilizer; 18 parts of fibrinogen; 8 parts of thrombin; 4 parts of blood coagulation factor VIII; 1.5 parts of aprotinin; 7 parts of menthol; 32 parts of natural rubber and 11 parts of acrylic copolymer.

The invention also provides the antibacterial high-adhesion medical glue and a preparation method thereof, and the production process of the antibacterial high-adhesion medical glue comprises the following steps: s1, pretreatment of prepared materials, S2, preparation of raw materials, S3, adding and mixing, S4, stirring initiation and S5, and quantitative packaging, wherein:

s1, pretreatment of prepared materials: selecting the following materials in proportion by weight: 45 parts of a-cyanoacrylate; 5 parts of a plasticizer; 6 parts of a tackifier; 7 parts of a stabilizer; 18 parts of fibrinogen; 8 parts of thrombin; 4 parts of blood coagulation factor VIII; 1.5 parts of aprotinin; 7 parts of menthol; 32 parts of natural rubber and 11 parts of acrylic copolymer;

s2, preparation of raw materials: the method comprises the following steps of a, preparing aloe gel, b, extracting cactus fruit extract, c, extracting wormwood liquid, wherein:

a. preparing aloe gel: selecting high-quality and quantitative aloe leaves, cleaning, peeling, crushing and homogenizing the aloe leaves to obtain aloe raw juice, centrifuging to obtain aloe raw juice, removing anthraquinone by using adsorption resin, removing calcium and magnesium by using ion exchange resin, mixing with carbomer ionized water, stirring and sterilizing;

b. extracting cactus fruit extract: selecting fresh cactus fruits, cleaning, peeling and crushing aloe leaves, homogenizing to obtain slurry, centrifuging to obtain stock solution, removing calcium and magnesium from the obtained stock solution by using ion exchange resin, and then distilling and extracting;

c. extracting wormwood liquid: selecting fresh folium Artemisiae Argyi, cleaning, crushing, mixing with water, homogenizing to obtain slurry, centrifuging to obtain stock solution, and concentrating by distillation;

s3, adding and mixing: s1, mixing the raw materials selected in the preparation pretreatment, and then extracting the aloe gel obtained in the step a, the extract obtained in the step b and the cactus fruit extract, and the wormwood liquid obtained in the step c;

s4, stirring and initiating: introducing the mixed solution prepared by adding and mixing in the step S3 into a stirring device for uniform stirring, adding an initiator during stirring, and adopting a mode of dropwise adding at an upper uniform speed and dropwise adding at a lower uniform speed when adding the initiator, wherein the stirring time is 20-30 min;

s5, quantitative packaging: and D, quantitatively packaging the glue obtained by stirring in the step S4 after vacuum sterilization.

Preferably, in step S1 of the preparation process, the plasticizer in the pretreatment of the stock is higher polyol ester (such as dioctyl sebacate), the tackifier is soluble polymer (such as polymethacrylate), and the stabilizer is hydroquinone and sulfur dioxide.

Preferably, in the step S1 of the preparation process, the menthol needs to be purified in the pretreatment of the stock preparation, a certain amount of crude menthol is weighed, and the purity of the menthol is improved by dissolving the crude menthol in a nitrile solvent, and then concentrating and crystallizing by distillation.

Preferably, in the preparation process step a, the aloe gel is prepared by swelling carbomer with ionized water for 12 to 14 hours.

Preferably, the preparation process comprises the step b, the cactus fruit extract is extracted, and the step c, the wormwood liquid are extracted, and the raw liquid is subjected to vacuum sterilization treatment, so that the quality of the cactus fruit extract and the wormwood liquid is improved.

Preferably, in the step b of the preparation process, the distillation temperature in the extraction of the cactus fruit extract and the step c of the extraction of the wormwood liquid is between 70 ℃ and 85 ℃, and the cactus fruit extract and the wormwood liquid are stirred at a constant speed in the distillation process.

Preferably, in the step S4 of the preparation process, the heat preservation is carried out in a steam heating mode when the initiator is dropwise added during stirring, the heating temperature is 40-60 ℃, uniform mixing is guaranteed, and the initiation effect is better.

Preferably, the preparation process step S5 includes three packaging qualities of 50ML, 100 ML and 150ML in quantitative packaging, and the packaging is carried out in a vacuum packaging mode.

Example 2

Referring to fig. 1-2, the present invention provides the following technical solutions: an antibacterial high-adhesion medical glue is composed of the following materials in parts by weight: 55 parts of a-cyanoacrylate; 45 parts of aloe gel; 29 parts of cactus fruit extract; 52 parts of wormwood extracting solution; 8 parts of a plasticizer; 12 parts of a tackifier; 8 parts of a stabilizer; 18 parts of fibrinogen; 14 parts of thrombin; 7 parts of blood coagulation factor VIII; 3 parts of aprotinin; 14 parts of menthol; 42 parts of natural rubber and 21 parts of acrylic copolymer.

The invention also provides the antibacterial high-adhesion medical glue and a preparation method thereof, and the production process of the antibacterial high-adhesion medical glue comprises the following steps: s1, pretreatment of prepared materials, S2, preparation of raw materials, S3, adding and mixing, S4, stirring initiation and S5, and quantitative packaging, wherein:

s1, pretreatment of prepared materials: selecting the following materials in proportion by weight: 55 parts of a-cyanoacrylate; 8 parts of a plasticizer; 12 parts of a tackifier; 8 parts of a stabilizer; 18 parts of fibrinogen; 14 parts of thrombin; 7 parts of blood coagulation factor VIII; 3 parts of aprotinin; 14 parts of menthol; 42 parts of natural rubber and 21 parts of acrylic copolymer;

s2, preparation of raw materials: the method comprises the following steps of a, preparing aloe gel, b, extracting cactus fruit extract, c, extracting wormwood liquid, wherein:

a. preparing aloe gel: selecting high-quality and quantitative aloe leaves, cleaning, peeling, crushing and homogenizing the aloe leaves to obtain aloe raw juice, centrifuging to obtain aloe raw juice, removing anthraquinone by using adsorption resin, removing calcium and magnesium by using ion exchange resin, mixing with carbomer ionized water, stirring and sterilizing;

b. extracting cactus fruit extract: selecting fresh cactus fruits, cleaning, peeling and crushing aloe leaves, homogenizing to obtain slurry, centrifuging to obtain stock solution, removing calcium and magnesium from the obtained stock solution by using ion exchange resin, and then distilling and extracting;

c. extracting wormwood liquid: selecting fresh folium Artemisiae Argyi, cleaning, crushing, mixing with water, homogenizing to obtain slurry, centrifuging to obtain stock solution, and concentrating by distillation;

s3, adding and mixing: s1, mixing the raw materials selected in the preparation pretreatment, and then extracting the aloe gel obtained in the step a, the extract obtained in the step b and the cactus fruit extract, and the wormwood liquid obtained in the step c;

s4, stirring and initiating: introducing the mixed solution prepared by adding and mixing in the step S3 into a stirring device for uniform stirring, adding an initiator during stirring, and adopting a mode of dropwise adding at an upper uniform speed and dropwise adding at a lower uniform speed when adding the initiator, wherein the stirring time is 20-30 min;

s5, quantitative packaging: and D, quantitatively packaging the glue obtained by stirring in the step S4 after vacuum sterilization.

Preferably, in step S1 of the preparation process, the plasticizer in the pretreatment of the stock is higher polyol ester (such as dioctyl sebacate), the tackifier is soluble polymer (such as polymethacrylate), and the stabilizer is hydroquinone and sulfur dioxide.

Preferably, in the step S1 of the preparation process, the menthol needs to be purified in the pretreatment of the stock preparation, a certain amount of crude menthol is weighed, and the purity of the menthol is improved by dissolving the crude menthol in a nitrile solvent, and then concentrating and crystallizing by distillation.

Preferably, in the preparation process step a, the aloe gel is prepared by swelling carbomer with ionized water for 12 to 14 hours.

Preferably, the preparation process comprises the step b, the cactus fruit extract is extracted, and the step c, the wormwood liquid are extracted, and the raw liquid is subjected to vacuum sterilization treatment, so that the quality of the cactus fruit extract and the wormwood liquid is improved.

Preferably, in the step b of the preparation process, the distillation temperature in the extraction of the cactus fruit extract and the step c of the extraction of the wormwood liquid is between 70 ℃ and 85 ℃, and the cactus fruit extract and the wormwood liquid are stirred at a constant speed in the distillation process.

Preferably, in the step S4 of the preparation process, the heat preservation is carried out in a steam heating mode when the initiator is dropwise added during stirring, the heating temperature is 40-60 ℃, uniform mixing is guaranteed, and the initiation effect is better.

Preferably, the preparation process step S5 includes three packaging qualities of 50ML, 100 ML and 150ML in quantitative packaging, and the packaging is carried out in a vacuum packaging mode.

The following are examples of the present invention:

experimental data:

watch 1

According to the invention, as shown in the table I, the medical glue disclosed by the invention is superior to the existing products in bonding strength, inflammation occurrence rate, degradation aging, hemostasis time and local hematoma rate, the medical glue is not influenced by blood coagulation disorders such as thrombocytopenia and the like by adding thrombin, blood coagulation factor VIII and aprotinin, is relatively quick in adhesion, free of excessive heat or pressure, free of influence of water at an adhesion part, good in biocompatibility and capable of being absorbed moderately, meanwhile, the medical glue is added with the aloe gel and wormwood extracting solution, has a certain inhibiting effect on various pathogenic fungi, has the effects of diminishing inflammation, sterilizing, relieving pain, absorbing heat to reduce swelling, softening skin and relieving pain and improving scars, and can cool and relieve pain, preserve and sterilize by adding menthol, and the cactus fruit extract can accelerate wound healing and promote skin cell regeneration.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.