阅读说明：本技术 免洗洗手液及其制备方法 (Wash-free hand sanitizer and preparation method thereof ) 是由 陈征 张晔翔 于 2020-07-22 设计创作，主要内容包括：本发明提供了一种免洗洗手液及其制备方法,其包括以下组分及其重量百分比：0.01-3％的神经酰胺2、0.01-3％的神经酰胺3、0.01-2.5％的硬脂酸、0.01-2.5％的胆甾醇、0.02-5％的乳化剂、0.04-10％的油脂、45-80％的酒精、0.01-2％的增稠剂、0.01-7％的润肤剂、0.01-2％的中和剂、0.001-2％的香精,余量为去离子水。本公开提供的免洗洗手液在满足杀菌、抑菌的前提下,可以有效提升皮肤的屏障修复功能,令肌肤长久保湿。(The invention provides a no-clean hand sanitizer and a preparation method thereof, wherein the no-clean hand sanitizer comprises the following components in percentage by weight: 0.01-3% of ceramide 2, 0.01-3% of ceramide 3, 0.01-2.5% of stearic acid, 0.01-2.5% of cholesterol, 0.02-5% of emulsifier, 0.04-10% of grease, 45-80% of alcohol, 0.01-2% of thickening agent, 0.01-7% of emollient, 0.01-2% of neutralizer, 0.001-2% of essence and the balance of deionized water. The washing-free hand sanitizer provided by the disclosure can effectively improve the barrier repair function of skin and keep moisture of the skin for a long time on the premise of meeting the requirements of sterilization and bacteriostasis.)

1. The no-clean hand sanitizer is characterized by comprising the following components in percentage by weight:

2. the wash-free hand sanitizer according to claim 1, wherein the wash-free hand sanitizer comprises the following components in percentage by weight:

3. the wash-free hand sanitizer according to claim 1, wherein the wash-free hand sanitizer comprises the following components in percentage by weight:

4. the leave-in hand sanitizer according to claim 1, wherein said emulsifier comprises one or more of hydrogenated lecithin, glycerol stearate.

5. The leave-in hand sanitizer according to claim 1, wherein said oils comprise one or more of methyl palmitate, dipropylene glycol, cetyl alcohol, and stearyl alcohol.

6. The leave-in hand sanitizer according to claim 1, wherein said thickener comprises one or more of a synthetic polymeric thickener and a natural polymeric thickener.

7. The leave-in hand sanitizer according to claim 1, wherein said emollient comprises one or more of polyhydric alcohol moisturizer, amide moisturizer, glucose ester moisturizer, collagen moisturizer, chitin derivative, chitosan moisturizer, betaine, and PEG shea butter.

8. The leave-in hand sanitizer according to claim 1, wherein the neutralizing agent comprises one or more of sodium hydroxide, potassium hydroxide, ammonium hydroxide, triethanolamine, aminomethyl propanol, tromethamine, 2-amino-2-hydroxymethyl-1, 3-propanediol, and tetrahydroxypropyl ethylenediamine.

9. A method of preparing a leave-in hand sanitizer according to any of claims 1 to 8 by:

mixing ceramide-2, ceramide-3, grease and emollient, heating to 70 ℃, and stirring until completely dissolved to obtain a first mixture;

mixing the first mixture with an emulsifier and stirring until the first mixture and the emulsifier are uniformly mixed to obtain a second mixture;

mixing the second mixture with cholesterol and stearic acid, and stirring until the mixture is uniformly mixed to obtain a third mixture;

homogenizing the third mixture, and homogenizing the third mixture after completely and uniformly mixing until no granular substances exist to obtain a fourth mixture;

mixing deionized water and a thickening agent, and stirring until the deionized water and the thickening agent are uniformly mixed to obtain a fifth mixture;

adding alcohol into the fifth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a sixth mixture;

adding a neutralizing agent into the sixth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a seventh mixture;

mixing the fourth mixture and the seventh mixture and stirring until the fourth mixture and the seventh mixture are uniformly mixed to obtain an eighth mixture;

adding essence into the eighth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a ninth mixture;

and stirring the ninth mixture until the ninth mixture is uniformly mixed, and adjusting the pH of the ninth mixture to 5-7.5 to obtain the no-clean hand sanitizer.

10. The method as set forth in claim 9, wherein the third mixed substance has a homogenizing speed of 9000-.

Technical Field

The invention relates to the technical field of no-clean hand sanitizer, and particularly relates to a no-clean hand sanitizer and a preparation method thereof.

Background

The no-clean hand sanitizer is the most common cleaning disinfectant in medical systems and civil systems at present, wherein alcohol is the most important and indispensable bactericidal substance in the no-clean hand sanitizer.

Due to the strong solubility and dehydration property of alcohol, the problems of dryness, dehydration, barrier damage and the like of the skin of a user applying the no-clean hand sanitizer can be caused. In a medical system, according to investigation, medical staff use the no-wash hand sanitizer about 50 times per day, and the hand skin health of the medical staff is seriously threatened. Meanwhile, the times of using the no-wash hand sanitizer by common people are more and more due to the occurrence of new coronary pneumonia, and then the problems of skin dryness, dehydration, barrier damage and the like can occur when the common no-wash hand sanitizer is used for multiple times.

Disclosure of Invention

In order to solve the above problems, a first aspect of the present disclosure provides a no-clean hand sanitizer, wherein the no-clean hand sanitizer includes the following components by weight:

in one embodiment, the no-clean hand sanitizer comprises the following components in percentage by weight:

in another embodiment, the no-clean hand sanitizer comprises the following components in percentage by weight:

in yet another embodiment, the emulsifier comprises one or more of hydrogenated lecithin, glyceryl stearate.

In yet another embodiment, the fat comprises one or more of methyl palmitate, dipropylene glycol, cetyl alcohol, and stearyl alcohol.

In yet another embodiment, the thickener comprises one or more of a synthetic polymeric thickener and a natural polymeric thickener.

In yet another embodiment, the emollient comprises one or more of a polyol moisturizer, an amide moisturizer, a glucose ester moisturizer, a collagen moisturizer, a chitin derivative, a chitosan moisturizer, betaine, and PEG shea butter.

In yet another embodiment, the neutralizing agent comprises one or more of sodium hydroxide, potassium hydroxide, ammonium hydroxide, triethanolamine, aminomethyl propanol, tromethamine, 2-amino-2-hydroxymethyl-1, 3-propanediol, tetrahydroxypropyl ethylenediamine.

In a second aspect of the present disclosure, there is provided a method for preparing a leave-in hand sanitizer according to the first aspect of the present disclosure or any one of the embodiments of the first aspect, wherein the preparation method is realized by the following steps:

mixing ceramide-2, ceramide-3, grease and emollient, heating to 70 ℃, and stirring until completely dissolved to obtain a first mixture;

mixing the first mixture with an emulsifier and stirring until the first mixture and the emulsifier are uniformly mixed to obtain a second mixture;

mixing the second mixture with cholesterol and stearic acid, and stirring until the mixture is uniformly mixed to obtain a third mixture;

homogenizing the third mixture, and homogenizing the third mixture after completely and uniformly mixing until no granular substances exist to obtain a fourth mixture;

mixing deionized water and a thickening agent, and stirring until the deionized water and the thickening agent are uniformly mixed to obtain a fifth mixture;

adding alcohol into the fifth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a sixth mixture;

adding a neutralizing agent into the sixth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a seventh mixture;

mixing the fourth mixture and the seventh mixture and stirring until the fourth mixture and the seventh mixture are uniformly mixed to obtain an eighth mixture;

adding essence into the eighth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a ninth mixture;

and stirring the ninth mixture until the ninth mixture is uniformly mixed, and adjusting the pH of the ninth mixture to 5-7.5 to obtain the no-clean hand sanitizer.

In one embodiment, the third mixture has a homogenization rate of 9000-.

The technical scheme provided by the embodiment of the disclosure can have the following beneficial effects: the washing-free hand sanitizer provided by the disclosure can effectively improve the barrier repair function of skin and keep moisture of the skin for a long time on the premise of meeting the requirements of sterilization and bacteriostasis.

Detailed Description

The principles and spirit of the present invention will be described with reference to a number of exemplary embodiments. It is understood that these embodiments are given solely for the purpose of enabling those skilled in the art to better understand and to practice the invention, and are not intended to limit the scope of the invention in any way.

Leave-on hand sanitizers are the most commonly used sanitizing agents in medical and residential systems. According to statistics, the frequency of using the no-clean hand sanitizer by nurses is up to more than 40 times per day.

At present, the common ethanol or isopropanol no-clean hand sanitizer has the following problems: 1. the alcohol concentration in the no-clean hand sanitizer is high, wherein the strong solubility and the dehydration property of the alcohol can cause the skin to be dry and sensitive due to the damage of a barrier; 2. the common alcohol no-clean hand sanitizer has the capability of quickly sterilizing without long-acting bacteriostasis, and the long-acting bacteriostasis can be achieved by adding non-alcohol bacteriostats such as glucose chlorhexidine, triclosan and the like and alcohol for overlapping use, but the common alcohol no-clean hand sanitizer has larger irritation to skin.

Furthermore, because the water solubility of the ceramide is poor, and the preparation technology and the formula are limited, no disposable hand sanitizer containing the ceramide is available at present.

The washing-free hand sanitizer provided by the disclosure can effectively improve the barrier repair function of skin on the premise of meeting sterilization and bacteriostasis, and enables the skin to be moisturized for a long time.

In an exemplary embodiment of the present disclosure, the no-clean hand sanitizer comprises the following components and weight percentages thereof:

in this embodiment, the alcohol is 100% pure alcohol. If the aqueous alcohol with the purity of less than 100% is selected, the required aqueous alcohol with the purity of less than 100% can be converted according to the required content of the 100% alcohol.

In the present disclosure, alcohol with an alcohol purity of 100% may be selected, and aqueous alcohol with a purity of less than 100% may also be selected, as long as the effective content of alcohol is finally ensured to be between 45% and 80%.

In one embodiment, 95% aqueous alcohol may be selected, wherein the 95% aqueous alcohol is present in the hands-free composition in an amount of 47.4% to 84.2%.

In an exemplary embodiment of the present disclosure, the no-clean hand sanitizer comprises the following components in percentage by weight:

in one embodiment, the emollient may include one or more of a polyol moisturizer, an amide moisturizer, a glucose ester moisturizer, a collagen moisturizer, a chitin derivative, a chitosan moisturizer, betaine, PEG shea butter, and a lactate moisturizer.

In addition to the emollient effect, betaine may also be used in leave-on hand sanitizers having a relatively low alcohol content, e.g., the alcohol content of the leave-on hand sanitizer may be 45%. At the moment, the no-clean hand sanitizer still has a good bacteriostatic action, and due to the fact that the content of alcohol is reduced, ceramide substances can exist better and stably, and further the no-clean hand sanitizer has better effects of moisturizing skin and repairing barriers.

In one embodiment, the no-clean hand sanitizer comprises the following components in percentage by weight:

in this embodiment, by adding betaine, the no-clean hand sanitizer disclosed by the present disclosure still has a good bacteriostatic effect under the condition of having a low content of alcohol.

In an exemplary embodiment of the present disclosure, the no-clean hand sanitizer comprises the following components in percentage by weight:

the non-washing hand sanitizer disclosed by the invention can enable ceramide with the effect of repairing a skin barrier to stably exist in an alcohol solution through reasonable proportioning, so that the barrier repairing function of the skin can be effectively improved on the premise of meeting the requirements of sterilization and bacteriostasis, and the skin is enabled to be moisturized for a long time.

In one embodiment, the emulsifier may include one or more of hydrogenated lecithin, glyceryl stearate.

In one embodiment, the fat may include one or more of methyl palmitate, dipropylene glycol, cetyl alcohol, and stearic acid.

In one embodiment, the thickener may include one or more of a synthetic polymeric thickener and a natural polymeric thickener. Wherein the synthetic polymer thickener comprises sodium polyacrylate, polyacrylamide, carbomer resin, polyvinylpyrrolidone and the like; the natural polymer thickener comprises xanthan gum, cellulose, biological sugar gum, etc.

In one embodiment, the neutralizing agent may include one or more of sodium hydroxide, potassium hydroxide, ammonium hydroxide, triethanolamine, aminomethyl propanol, tromethamine, 2-amino-2-hydroxymethyl-1, 3-propanediol, tetrahydroxypropyl ethylenediamine.

A method of preparing a leave-in hand sanitizer according to the first aspect of the present disclosure will now be described. The preparation method is realized by the following steps:

mixing ceramide-2, ceramide-3, oil and emollient, heating to 70 ℃, and stirring to completely dissolve to obtain a first mixture.

And mixing the first mixture with an emulsifier and stirring until the first mixture and the emulsifier are uniformly mixed to obtain a second mixture.

And mixing the second mixture with cholesterol and stearic acid, and stirring until the mixture is uniformly mixed to obtain a third mixture.

And homogenizing the third mixture, and homogenizing the third mixture after completely and uniformly mixing until no granular substances exist to obtain a fourth mixture.

And mixing the deionized water and the thickening agent, and stirring until the deionized water and the thickening agent are uniformly mixed to obtain a fifth mixture.

Adding alcohol to the fifth mixture, mixing and stirring until uniform mixing to obtain a sixth mixture.

And adding a neutralizing agent into the sixth mixture, mixing and stirring until uniform mixing is achieved to obtain a seventh mixture.

And mixing the fourth mixture and the seventh mixture and stirring until the fourth mixture and the seventh mixture are uniformly mixed to obtain an eighth mixture.

Adding essence into the eighth mixture, mixing and stirring until uniform mixing to obtain a ninth mixture.

And stirring the ninth mixture until the ninth mixture is uniformly mixed, and adjusting the pH of the ninth mixture to 5-7.5 to obtain the no-clean hand sanitizer.

Or stirring the ninth mixture until the ninth mixture is uniformly mixed, and adjusting the pH of the ninth mixture to 6.0-6.5 to obtain the no-clean hand sanitizer.

In one embodiment, the agitated mixture may be agitated by a stirrer. The model of the stirrer is RW20 Digital, and the stirring speed of the stirrer can be 500-1000 rpm.

In one embodiment, the third mixture has a homogenization speed of 9000-. In this way, the third mixture can be guaranteed to be sufficiently homogeneous, and a foundation is laid for guaranteeing the stable existence of the ceramide 2 and the ceramide 3 in the alcohol solution.

Various examples and comparative examples of leave-on hand sanitizers described in connection with the present disclosure are described in detail below.

In the following examples, experimental methods not specified for specific conditions were selected or determined according to conventional methods and conditions, or according to the commercial instructions.

In the following examples, unless otherwise specified, all experimental materials used are generally commercially available.

Example 1

The no-clean hand sanitizer according to one embodiment of the present disclosure comprises the following components by weight:

the leave-on hand sanitizer of this example was prepared as follows:

mixing ceramide-2, ceramide-3, methyl palmitate, dipropylene glycol, cetyl alcohol, stearyl alcohol and betaine, heating to 70 ℃, and stirring until completely dissolved to obtain a first mixture;

mixing the first mixture with hydrogenated lecithin and glycerol stearate, and stirring until the first mixture is uniformly mixed to obtain a second mixture;

mixing the second mixture with cholesterol and stearic acid, and stirring until the mixture is uniformly mixed to obtain a third mixture;

homogenizing the third mixture, and homogenizing the third mixture after completely and uniformly mixing until no granular substances exist to obtain a fourth mixture;

mixing deionized water and xanthan gum, and stirring until the deionized water and the xanthan gum are uniformly mixed to obtain a fifth mixture;

adding alcohol into the fifth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a sixth mixture;

adding tromethamine into the sixth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a seventh mixture;

mixing the fourth mixture and the seventh mixture and stirring until the fourth mixture and the seventh mixture are uniformly mixed to obtain an eighth mixture;

adding essence into the eighth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a ninth mixture;

and stirring the ninth mixture until the ninth mixture is uniformly mixed, and adjusting the pH of the ninth mixture to 5-7.5 to obtain the no-clean hand sanitizer.

Wherein the third mixed material has a homogenizing speed of 9000-10000 rpm.

The mixture was stirred by means of a stirrer, model RW20 Digital, the stirring speed of which may be 500 and 1000 revolutions per minute.

Example 2

The no-clean hand sanitizer according to one embodiment of the present disclosure comprises the following components by weight:

the preparation method of this example is the same as example 1.

Example 3

The no-clean hand sanitizer according to one embodiment of the present disclosure comprises the following components by weight:

the leave-on hand sanitizer of this example was prepared as follows:

mixing ceramide-2, ceramide-3, methyl palmitate, dipropylene glycol, cetyl alcohol, stearyl alcohol, betaine, glycerol and PEG-75 shea butter, heating to 70 ℃, and stirring until completely dissolved to obtain a first mixture;

mixing the first mixture with hydrogenated lecithin and glycerol stearate, and stirring until the first mixture is uniformly mixed to obtain a second mixture;

mixing the second mixture with cholesterol and stearic acid, and stirring until the mixture is uniformly mixed to obtain a third mixture;

homogenizing the third mixture, and homogenizing the third mixture after completely and uniformly mixing until no granular substances exist to obtain a fourth mixture;

mixing deionized water and xanthan gum, and stirring until the deionized water and the xanthan gum are uniformly mixed to obtain a fifth mixture;

adding alcohol into the fifth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a sixth mixture;

adding tromethamine into the sixth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a seventh mixture;

mixing the fourth mixture and the seventh mixture and stirring until the fourth mixture and the seventh mixture are uniformly mixed to obtain an eighth mixture; adding essence into the eighth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a ninth mixture;

and stirring the ninth mixture until the ninth mixture is uniformly mixed, and adjusting the pH of the ninth mixture to 5-7.5 to obtain the no-clean hand sanitizer.

The third mixed material has a homogenizing speed of 9000-.

The mixture was stirred by means of a stirrer, model RW20 Digital, the stirring speed of which may be 500 and 1000 revolutions per minute.

Example 4

The no-clean hand sanitizer according to one embodiment of the present disclosure comprises the following components by weight:

the preparation method of this example is the same as example 4.

Comparative example 1

The no-clean hand sanitizer described in comparative example 1 comprises the following components in percentage by weight:

comparative example 2

The no-clean hand sanitizer described in comparative example 2 consists of the following components in percentage by weight:

comparative example 3

The no-clean hand sanitizer described in comparative example 3 comprises the following components in percentage by weight:

the leave-in hand sanitizer of this comparative example was prepared as follows:

mixing ceramide-2, ceramide-3, methyl palmitate, dipropylene glycol, cetyl alcohol, stearyl alcohol, betaine, glycerol and PEG-75 shea butter, heating to 70 ℃, and stirring until completely dissolved to obtain a first mixture;

mixing the first mixture with hydrogenated lecithin and glycerol stearate, and stirring until the first mixture is uniformly mixed to obtain a second mixture;

mixing the second mixture with cholesterol and stearic acid, and stirring until the mixture is uniformly mixed to obtain a third mixture;

mixing deionized water and xanthan gum, and stirring until the deionized water and the xanthan gum are uniformly mixed to obtain a fourth mixture;

adding alcohol into the fourth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a fifth mixture;

adding tromethamine into the fifth mixture, mixing and stirring until the mixture is uniformly mixed to obtain a sixth mixture;

mixing the third mixture and the sixth mixture and stirring until the third mixture and the sixth mixture are uniformly mixed to obtain a seventh mixture;

adding essence into the seventh mixture, mixing and stirring until the essence is uniformly mixed to obtain an eighth mixture;

stirring the eighth mixture until uniformly mixed, and adjusting the pH of the eighth mixture to 5-7.5 to obtain the no-clean hand sanitizer of comparative example 3.

The third mixed material has a homogenizing speed of 9000-.

The mixture was stirred by means of a stirrer, model RW20 Digital, the stirring speed of which may be 500 and 1000 revolutions per minute.

Comparative example 4

The no-clean hand sanitizer described in comparative example 4 comprises the following components in percentage by weight:

the comparative example was prepared in the same manner as comparative example 3.

Comparative example 5

The no-clean hand sanitizer described in comparative example 5 consists of the following components in percentage by weight:

the leave-in hand sanitizer of this comparative example was prepared according to conventional preparation methods (i.e., separately preparing the oil phase and the aqueous phase, and then mixing the oil phase and the aqueous phase to obtain the product):

mixing ceramide 2, ceramide 3, stearic acid, cholesterol, hydrogenated lecithin, methyl palmitate and PEG-75 shea butter, stirring, and heating to 70 deg.C to obtain a first mixture;

mixing glyceryl stearate, alcohol, dipropylene glycol, cetyl alcohol, stearyl alcohol, xanthan gum, betaine, glycerol and deionized water, stirring, and heating to 70 deg.C to obtain a second mixture;

slowly adding the first mixture into the second mixture, and then homogenizing at a high speed to obtain a third mixture, wherein the homogenizing speed is 7000-10000 rpm;

and uniformly mixing tromethamine, essence and the third mixture to obtain the no-clean hand sanitizer of the comparative example 5.

Barrier repair and moisturizing effects:

the TEWL test is an important parameter for evaluating the function of the skin moisture protection layer and has been widely accepted internationally. The lower the value of the percutaneous water loss TEWL is, the more complete the skin protection layer is and the stronger the water locking capacity is; conversely, the weaker the skin's ability to lock water.

The unit of TEWL is: g/hm². During the preparation process of products such as cosmetics, wash-free hand sanitizer and the like, the barrier repair capability of the products can be evaluated by testing the TEWL value, and the effects of the products on skin allergy, contact dermatitis, physical therapy, burn and the like can be further characterized.

The skin moisture test is an important parameter for evaluating the moisturizing effect of skin. The skin moisture content is determined by both internal and external factors, the internal cause being the greater ability of the stratum corneum to retain moisture, consisting of the respiratory process of the skin sweating and the water mixture in the skin; external causes include ambient temperature, humidity, drug and skin care composition.

The moisture content of the skin can affect the formation of a water and grease mixed film on the surface of the skin, and the protective film is crucial to preventing the skin from aging, so that the quantitative test of the moisture content of the skin plays an important role. The higher the value of the skin moisture test, the better the moisturizing effect of the skin, and conversely, the poorer the moisturizing effect of the skin.

1. The test instrument: the percutaneous moisture loss measuring instrument Tewameter TM300, Courage + Khazaka Germany, it should be noted that the percutaneous moisture loss measuring instrument Tewameter TM300 can measure both the percutaneous moisture loss TEWL data and the skin moisture data. When the percutaneous water loss TEWL data test is required, a probe corresponding to the percutaneous water loss TEWL test can be connected with the skin to be detected; when the skin moisture data test is needed, the probe corresponding to the skin moisture test can be connected with the skin to be tested.

2. The test method comprises the following steps: 130 volunteers 18-65 years of age (none had systemic disease and had not received tests that might affect the outcome of the trial) were randomized into 13 groups of 10 individuals each.

The hand washing treatment was carried out by using three kinds of commercially available wash-free hand washing solutions and a blank control group, example 1 to example 4, comparative example 1 to comparative example 5, respectively. The blank control group was a group that was subjected to hand washing treatment using only deionized water.

TEWL (percutaneous water loss) values and skin moisture values were tested and recorded for volunteers immediately after hand washing treatment, 0.5 hour after hand washing treatment, 1 hour after hand washing treatment, 1.5 hours after hand washing treatment, 2 hours after hand washing treatment, 2.5 hours after hand washing treatment and 3 hours after hand washing treatment.

Table 1 shows the results of TEWL (trans-epidermal water loss) tests of hand washing treatments using examples 1 to 4, comparative examples 1 to 5, commercial products and blank control components, respectively. The commercially available products are three kinds of common no-clean hand washing solutions in the market, and the commercially available products also contain a humectant.

TABLE 1 TEWL (percutaneous Water loss) test results comparison Table

As can be seen from table 1, the TEWL (moisture loss through skin) value of the volunteers after hand washing treatment with the non-wash hand sanitizer of the examples was significantly lower than the TEWL (moisture loss through skin) value of the volunteers after hand washing treatment with the non-wash hand sanitizer of the commercial product or the blank control group. The washing-free hand sanitizer related to the disclosure has a good skin barrier repair function.

Further, the wash-free hand sanitizer provided by the embodiment has a good skin barrier repair function within 3 hours after hand washing treatment.

The TEWL (trans-skin moisture loss) values measured using the leave-on hand cleanser of comparative example 2 were significantly higher than the TEWL (trans-skin moisture loss) values measured using the leave-on hand cleanser of the examples. This is because the leave-on hand sanitizer of comparative example 2 lacks stearic acid and cholesterol, so that ceramide 2 and ceramide 3 do not well exist in an alcohol solution, and further, the skin barrier repair function of the user is poorer than that of comparative example 2.

The TEWL (trans-skin moisture loss) values measured using the leave-on hand cleansers of comparative example 3 or comparative example 4 were significantly higher than the TEWL (trans-skin moisture loss) values measured using the leave-on hand cleansers of the examples. This is because the leave-on hand cleansers of comparative example 3 or comparative example 4 do not guarantee that ceramide 2 and ceramide 3 are well present in the system of the leave-on hand cleanser. Part of ceramide 2 and ceramide 3 is separated out from the no-clean hand sanitizer system, so that the effective components of the ceramide 2 and the ceramide 3 in the no-clean hand sanitizer are reduced, and further, the skin barrier repair function of a user using the no-clean hand sanitizer of the comparative example 3 or the comparative example 4 is poor.

The product of comparative example 5 prepared by the conventional preparation method cannot stably exist, so that the product does not have the barrier repair effect, and thus, the TEWL (trans-dermal water loss) value measured by using the leave-on hand sanitizer of comparative example 5 is equivalent to the effect of the blank control group. Therefore, the product prepared by the conventional preparation method only without the preparation method disclosed by the invention is not provided with the skin barrier repair function.

Table 2 shows the results of skin moisturization tests using hand washing treatments of examples 1 to 4, comparative examples 1 to 5, commercially available products, three types of no-wash hand cleaners that are commonly available on the market, and a blank control group.

TABLE 2 comparison of test results for skin moisture values

As can be seen from table 2, the skin moisture value of the volunteers after hand washing treatment with the wash-free hand sanitizer of the examples was significantly higher than the skin moisture value of the volunteers after hand washing treatment with the wash-free hand sanitizer of the commercial product or the blank control group. The washing-free hand sanitizer disclosed by the disclosure has good functions of keeping skin moisture and moistening skin.

Furthermore, after the hand washing treatment is carried out by using the no-clean hand sanitizer of the embodiment, the functions of keeping the moisture of the skin and moistening the skin can be achieved within 3 hours.

The skin moisture values measured using the leave-on hand cleanser of comparative example 2 were significantly lower than those measured using the leave-on hand cleansers of the examples. This is because the no-wash hand sanitizer of comparative example 2 lacks stearic acid and cholesterol, so that ceramide 2 and ceramide 3 cannot be well present in the alcohol solution, and further, the skin barrier repair function of the user using the no-wash hand sanitizer of comparative example 2 is poor, and the skin moisture retention of the user is also affected.

The skin moisture values measured using the no-wash lotions of comparative example 3 or comparative example 4 were significantly lower than the skin moisture values measured using the no-wash lotions of the examples. This is because the leave-on hand cleansers of comparative example 3 or comparative example 4 do not guarantee that ceramide 2 and ceramide 3 are well present in the system of the leave-on hand cleanser. Part of ceramide 2 and ceramide 3 is separated out from the no-clean hand sanitizer system, so that the effective components of the ceramide 2 and the ceramide 3 in the no-clean hand sanitizer are reduced, the skin barrier repair function of a user using the no-clean hand sanitizer of the comparative example 3 or the comparative example 4 is poor, and the skin moisture retention of the user is influenced.

The product corresponding to comparative example 5 prepared by the conventional preparation method cannot stably exist, so that the product does not have the moisturizing effect. Therefore, the product prepared by using the raw materials of the no-clean hand sanitizer disclosed by the disclosure and only using the conventional preparation method without using the preparation method disclosed by the disclosure has no moisturizing effect.

The sterilization effect is as follows:

the sterilization effect of the natural bacteria on the hands of the volunteers after the hand washing treatment using the three kinds of the wash-free hand cleaners, which are commercially available, of example 1 to example 4, comparative example 1 to comparative example 5, and the blank control group was tested.

During the test, the initial content of natural bacteria on the hands of the volunteers may be first measured. And then the hands are respectively smeared with three kinds of common washing-free hand-washing liquid and a blank control group which are sold in examples 1 to 4 and comparative examples 1 to 5, and after being scrubbed for 2 minutes, the hands are thoroughly washed and are wiped by a sterile towel. The sterilized content of the natural bacteria on the hands of the volunteers was then measured.

Based on the initial content of natural bacteria on hands of volunteers and the content of the natural bacteria after sterilization, the sterilization amount of the natural bacteria is obtained by using three types of common no-clean hand washing solutions sold in examples 1 to 4, comparative examples 1 to 5 and a blank control group.

Wherein the natural bacteria can be Staphylococcus aureus, Escherichia coli, Nongnong and Candida albicans.

Table 3 shows the results of the tests of the bacteriostatic effect of the hand washing treatment using examples 1 to 4, comparative examples 1 to 5, commercially available products, and a blank control group, wherein the commercially available products are three types of non-wash hand cleaners commonly available on the market.

TABLE 3 comparison table of test results of bacteriostatic effect

As shown in Table 3, after the volunteers wash hands with the wash-free hand sanitizer of the embodiment, the bacteriostatic effect can reach the industrial standard (the killing log value is more than 5.00). The washing-free hand sanitizer disclosed by the embodiment of the disclosure has good sterilization and bacteriostasis effects.

The product corresponding to comparative example 5 prepared by the conventional preparation method cannot exist stably, so that the product does not have a good sterilization effect.

Further, by comparing example 4 with comparative example 1, when the content of alcohol in the no-clean hand sanitizer is 45%, the bacteriostatic effect of the no-clean hand sanitizer can be improved by adding betaine. The washing-free hand sanitizer disclosed by the disclosure can still have a bacteriostatic action when the alcohol content in the washing-free hand sanitizer is low (45%) due to the existence of betaine. In addition, due to the reduction of the alcohol content, the effects of moisturizing and barrier repair of the no-wash hand sanitizer are better. The foregoing description of the implementation of the invention has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise form disclosed, and modifications and variations are possible in light of the above teachings or may be acquired from practice of the invention. The embodiments were chosen and described in order to explain the principles of the invention and its practical application to enable one skilled in the art to utilize the invention in various embodiments and with various modifications as are suited to the particular use contemplated.