阅读说明：本技术 一种用于防治鸡传染性法氏囊病的中药组合物 (Traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken ) 是由 杨成祥 赵云生 赵蕾 于 2021-10-28 设计创作，主要内容包括：本发明属于中药领域,具体涉及一种用于防治鸡传染性法氏囊病的中药组合物和兽药技术领域。是由下述重量的原料制成：蒲公英100g-300g、大青叶100g～300g、板蓝根100g～300g、金银花50g～150g、黄芩50g～150g、黄柏50g～150g、甘草50g～150g、藿香30g～70g、生石膏30g～70g、冰硼散30g～70g。本发明中药组合物用于预防和治疗由鸡法氏囊病毒感染引起的鸡传染性法氏囊病。使用方法是该组合物饮水或拌料,连用3～5天为一疗程。本发明对防治鸡传染性法氏囊病具有高度敏感性,效果好,耐药性低,使用方便,能大大降低发病鸡群的死亡率,可有效防治由鸡法氏囊病毒引起的鸡传染性法氏囊病,促进发病鸡及其法氏囊的康复,恢复其生长发育。而且本发明的中药组合物为纯植物提取成分,无任何残留性添加成分,绿色环保,避免了兽药残留和社会公害的发生,具有很好的推广和应用价值。(The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken and the technical field of veterinary medicines. Is prepared from the following raw materials by weight: 100-300 g of dandelion, 100-300 g of folium isatidis, 100-300 g of radix isatidis, 50-150 g of honeysuckle, 50-150 g of scutellaria baicalensis, 50-150 g of golden cypress, 50-150 g of liquorice, 30-70 g of agastache rugosus, 30-70 g of gypsum and 30-70 g of Bingpeng powder. The traditional Chinese medicine composition is used for preventing and treating infectious bursal disease of chicken caused by the infection of the bursal disease virus of chicken. The application method is that the composition is used for drinking water or mixing materials, and 3-5 days are continuously used as a treatment course. The invention has high sensitivity to the control of the chicken infectious bursal disease, good effect, low drug resistance and convenient use, can greatly reduce the mortality of sick chicken, can effectively control the chicken infectious bursal disease caused by the chicken bursal disease virus, promotes the recovery of the sick chicken and the bursa thereof, and recovers the growth and development of the sick chicken and the bursa thereof. The traditional Chinese medicine composition is a pure plant extract component, has no any residual additive component, is green and environment-friendly, avoids veterinary drug residue and social public nuisance, and has good popularization and application values.)

1. A traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken is characterized by being prepared from the following raw materials by weight: 100-300 g of dandelion, 100-300 g of folium isatidis, 100-300 g of radix isatidis, 50-150 g of honeysuckle, 50-150 g of scutellaria baicalensis, 50-150 g of golden cypress, 50-150 g of liquorice, 30-70 g of agastache rugosus, 30-70 g of gypsum and 30-70 g of Bingpeng powder, and the method specifically comprises the following steps:

the Bingpeng powder is prepared from 50g of borneol, 500g of calcined borax, 60g of cinnabar and 500g of glauber salt, the four medicines are processed, the cinnabar is refined into superfine powder by water, the borax is crushed into fine powder, the borneol is ground, the powder and the glauber salt are ground, sieved and mixed uniformly, and 30g-70g of the Bingpeng powder is taken for standby;

step (2), slicing the dandelion, the dyers woad leaf, the radix isatidis, the honeysuckle, the scutellaria baicalensis, the phellodendron, the liquorice and the agastache rugosus as claimed in the claim 1 into pieces, and crushing the gypsum into pieces;

and (3) further, according to the prepared materials obtained in the step (2), firstly, crushing the sliced prepared materials, then adding the crushed raw gypsum prepared materials and the Bingpeng powder obtained in the step (1), mixing, and sieving by a 80-mesh sieve to obtain the product.

2. The traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken as claimed in claim 1, which is prepared from the following raw materials by weight: 100g of dandelion, 100g of folium isatidis, 100g of radix isatidis, 50g of honeysuckle, 50g of scutellaria baicalensis, 50g of phellodendron, 50g of liquorice, 30g of agastache rugosus, 30g of gypsum and 30g of borneol boron powder, and the preparation method is obtained according to the step of claim 1.

3. The traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken as claimed in claim 1, which is prepared from the following raw materials by weight: 300g of dandelion, 300g of folium isatidis, 300g of radix isatidis, 150g of honeysuckle, 150g of scutellaria baicalensis, 150g of golden cypress, 150g of liquorice, 70g of agastache rugosus, 70g of gypsum and 70g of Bingpeng powder, and the preparation method is obtained according to the step of claim 1.

4. The traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken as claimed in claim 1, which is prepared from the following raw materials by weight: 200g of dandelion, 200g of folium isatidis, 200g of radix isatidis, 100g of honeysuckle, 100g of scutellaria baicalensis, 100g of golden cypress, 100g of liquorice, 50g of agastache rugosus, 50g of gypsum and 50g of Bingpeng powder, and the preparation method is obtained according to the step of claim 1.

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken and the technical field of veterinary medicines. In particular to a Chinese medicinal composition which takes Chinese herbal medicines as raw material medicines and is used for treating and preventing infectious bursal disease of chicken caused by bursal disease virus.

Background

Infectious Bursal Disease (IBD) is an acute and contact infectious disease caused by reovirus (double-strand double-segmented RNA virus with strong tolerance and mainly composed of four structural proteins of VP1, VP2, VP3 and VP 4). The clinical manifestations are mental retardation, inappetence, lethargy and yellow-white watery stool excretion. The change of the dissection is mainly characterized by chest muscle and thigh zonal hemorrhage, large hemorrhage or atrophy of bursa of Fabricius, and cheese-like foreign matter in the change. The disease is sudden and rapid in onset and spread, and also can destroy bursa of fabricius to cause immunosuppression or immunologic function reduction of chicken, so that the vaccine inoculated for preventing other diseases cannot achieve the expected immune effect, thereby causing other infectious diseases to invade, causing secondary infection, causing mass death of chicken, and causing serious damage to the benefit of farmers, therefore, the disease needs to be actively prevented and treated. Currently, the main prevention and treatment means is to inject chicken infectious bursal disease high-immunity yolk antibody or prevent by adopting an emergency bursal disease vaccine injection method. Although the two methods are effective, the two methods both need to be used by injection, the operation is extremely troublesome, and the stress and the casualties to chicken flocks are large, so that the health and the growth and development of the chicken flocks are influenced, and a large biological safety risk also exists.

Disclosure of Invention

In order to effectively prevent and treat the infectious bursal disease of chicken and fully ensure the healthy development of the chicken industry, through a large number of researches and clinical practices, the inventor develops the traditional Chinese medicine composition for preventing and treating the infectious bursal disease of chicken.

The traditional Chinese medicine composition for preventing and treating the infectious bursal disease of the chicken can obviously enhance the curative effect of preventing and treating the infectious bursal disease of the chicken and can play a great role in preventing and treating the infectious bursal disease of the chicken. Not only can effectively prevent the infectious bursal disease of chickens, but also can greatly reduce the morbidity and mortality of sick chicken flocks; and the medicine is safe and effective, has no medicine residue, is very convenient to use and operate, and can promote the quick recovery of sick chickens and quickly recover the growth and development of the sick chickens. Through the comparative analysis of experimental data on the prevention and treatment effects of the traditional Chinese medicine and the western medicine of the infectious bursal disease of chicken, the traditional Chinese medicine composition in the formula has more remarkable effect than the western medicine when being clinically used for preventing and treating the infectious bursal disease of chicken. And the prevention and treatment of the traditional Chinese medicine have the important significance of environmental protection, economy and practicability and better effect.

The technical problem to be solved by the invention is realized by the following technical approaches.

The invention relates to a traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken, and aims to provide a traditional Chinese medicine composition with antiviral, antibacterial and anti-inflammatory functions, which can effectively prevent and treat the infectious bursal disease of chicken and mainly comprises the following components in parts by weight: 100-300 g of dandelion, 100-300 g of folium isatidis, 100-300 g of radix isatidis, 50-150 g of honeysuckle, 50-150 g of scutellaria baicalensis, 50-150 g of golden cypress, 50-150 g of liquorice, 30-70 g of agastache rugosus, 30-70 g of gypsum and 30-70 g of Bingpeng powder.

The method specifically comprises the following steps:

the Bingpeng powder is prepared from 50g of borneol, 500g of calcined borax, 60g of cinnabar and 500g of glauber salt, the four medicines are processed, the cinnabar is refined into superfine powder by water, the borax is crushed into fine powder, the borneol is ground, the powder and the glauber salt are ground, sieved and mixed uniformly, and 30g-70g of the Bingpeng powder is taken for standby;

step (2), slicing the dandelion, the dyers woad leaf, the radix isatidis, the honeysuckle, the scutellaria baicalensis, the phellodendron, the liquorice and the agastache rugosus as claimed in the claim 1 into pieces, and crushing the gypsum into pieces;

and (3) further, according to the prepared materials obtained in the step (2), firstly, crushing the sliced prepared materials, then adding the crushed raw gypsum prepared materials and the Bingpeng powder obtained in the step (1), mixing, and sieving by a 80-mesh sieve to obtain the product.

The traditional Chinese medicine composition is fed to livestock and poultry in modes of drinking water or mixed feeding and the like, so that the infectious bursal disease of chicken can be effectively prevented and treated. The veterinary drug composition of the invention uses the treatment thinking of traditional veterinary medical science and law prescription drugs, and selects the drugs according with the disease condition on the basis of dialectical methods, aiming at playing the synergistic action of the drugs in order to meet the requirements of complex disease conditions.

Detailed Description

The invention is described below with reference to examples, which are not intended to limit the invention, but which may be modified and varied by a person skilled in the art in accordance with the spirit of the invention, all such modifications and variations being considered to be within the scope of the invention.

It should be noted that, in view of the needs in large-scale cultivation, the farmer may choose to administer the drug as a mixed drink or as a mixed feed. The invention has the effects of resisting and inhibiting virus, clearing heat, enhancing immunity and the like in clinical practice and application of veterinary medicines, and has good curative effect on preventing and treating the chicken infectious bursal disease.

Example 1:

a traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken is prepared from the following raw materials by weight: 100-300 g of dandelion, 100-300 g of folium isatidis, 100-300 g of radix isatidis, 50-150 g of honeysuckle, 50-150 g of scutellaria baicalensis, 50-150 g of golden cypress, 50-150 g of liquorice, 30-70 g of agastache rugosus, 30-70 g of gypsum and 30-70 g of Bingpeng powder.

The method specifically comprises the following steps:

the Bingpeng powder is prepared from 50g of borneol, 500g of calcined borax, 60g of cinnabar and 500g of glauber salt, the four medicines are processed, the cinnabar is refined into superfine powder by water, the borax is crushed into fine powder, the borneol is ground, the powder and the glauber salt are ground, sieved and mixed uniformly, and 30g-70g of the Bingpeng powder is taken for standby;

step (2), slicing the dandelion, the dyers woad leaf, the radix isatidis, the honeysuckle, the scutellaria baicalensis, the phellodendron, the liquorice and the agastache rugosus as claimed in the claim 1 into pieces, and crushing the gypsum into pieces;

and (3) further, according to the prepared materials obtained in the step (2), firstly, crushing the sliced prepared materials, then adding the crushed raw gypsum prepared materials and the Bingpeng powder obtained in the step (1), mixing, and sieving by a 80-mesh sieve to obtain the product.

The traditional Chinese medicine composition is fed to livestock and poultry in modes of drinking water or mixed feeding and the like, so that the infectious bursal disease of chicken can be effectively prevented and treated. The Chinese medicinal composition applies the treatment thinking of Chinese veterinary medical science and law prescription medicaments, selects the medicaments according with the state of an illness on the basis of dialectical methods, and aims to meet the requirements of complex states of an illness and exert the synergistic action of the medicaments.

Example 2:

a traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken is prepared from the following raw materials by weight: 100g of dandelion, 100g of folium isatidis, 100g of radix isatidis, 50g of honeysuckle, 50g of scutellaria baicalensis, 50g of golden cypress, 50g of liquorice, 30g of agastache rugosus, 30g of gypsum and 30g of borneol powder, and the preparation method is obtained according to the steps in the embodiment 1.

Example 3:

a traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken is prepared from the following raw materials by weight: 300g of dandelion, 300g of folium isatidis, 300g of radix isatidis, 150g of honeysuckle, 150g of scutellaria baicalensis, 150g of golden cypress, 150g of liquorice, 70g of agastache rugosus, 70g of gypsum and 70g of Bingpeng powder, and the preparation method is obtained according to the steps in the embodiment 1.

Example 4:

a traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken is prepared from the following raw materials by weight: 200g of dandelion, 200g of folium isatidis, 200g of isatis root, 100g of honeysuckle, 100g of scutellaria baicalensis, 100g of golden cypress, 100g of liquorice, 50g of agastache rugosus, 50g of gypsum and 50g of borneol boron powder, and the preparation method is obtained according to the steps in the embodiment 1.

Clinical experimental example 1:

contrast experiment research on prevention and treatment of traditional Chinese medicine composition for preventing and treating infectious bursal disease of chicken

1. Materials and methods

1.1 materials of interest

1.1.1 Experimental drugs

(1) Western medicines: compound Juenotong tablets (0.25 g/tablet) (Shanghai certain pharmaceutical Co., Ltd.); immune amino-multivitamin (some biotech ltd, shanghai); a highly immune yolk antibody injection (250 ml/bottle) prepared from bursal disease (Henan Narisen biological pharmaceutical Co., Ltd.); live vaccine (lyophilized vaccine, 1000 feathers) for infectious bursal disease of chicken (a certain bioengineering Co., Ltd.).

(2) Chinese herbal medicines: the traditional Chinese medicine composition comprises the following components: 200g of dandelion, 200g of dyers woad leaf, 200g of isatis root, 100g of honeysuckle, 100g of scutellaria baicalensis, 100g of phellodendron, 100g of liquorice, 50g of agastache rugosus, 50g of gypsum and 50g of Bingpeng powder.

(3) Suspension of bursal tissue from a typical bursal disease dead chicken (virulent): 100mL of the suspension is used for later use and is hereinafter referred to as virulent suspension. Preparing tissue suspension with 4 times dilution of typical lesion bursa of Fabricius collected from local region with PBS solution with pH value of 7.2 by conventional method, adding appropriate amount of double antibody, repeatedly freezing and thawing for 4 times, centrifuging (3000 r/min) for 30min, and collecting supernatant.

1.1.2 test ducks: 1000 healthy iron foot ramie chicks of 1 day age (purchased from a certain culture limited company of Xuan city of Anhui, the chicks are not inoculated with infectious bursal disease vaccine and are raised in a clean room which is strictly fumigated and disinfected by formalin, and weak residual chickens are eliminated for later use after being aged to 21 days).

1.2 methods of investigation

1.2.1 diagnosis

(1) And (3) laboratory diagnosis, namely taking the virulent suspension, carrying out artificial infection on 10 21-25-day-old test chickens through nasal drip or oral administration, wherein symptoms appear 48-72 hours after infection, and the bursa of Fabricius characteristic lesion exists after necropsy autopsy.

(2) Agar diffusion test: performing agar expansion test on bursa of Fabricius tissue of the dead test chicken and bursa of Fabricius positive serum, wherein the result shows positive reaction; blood, spleen, bursa of Fabricius and the like of the dead chicken are taken, bacteria are not found through contact lens examination, and then the disease material is respectively inoculated into a common agar culture medium and cultured at the constant temperature of 37 ℃ for 24-48 h without bacterial growth.

(3) Virus separation and identification: grinding bursa or spleen of test chicken died of disease, adding sterilized normal saline, centrifuging, adding double-antibody inoculated chicken embryo to cause death (edema or hemorrhage), and identifying IBDV.

For better diagnosis, the above methods can be used simultaneously.

1.2.2 test drug formulation and methods of use

(1) Preparing Chinese herbal medicines: the traditional Chinese medicine composition is prepared into a traditional Chinese medicine mixed liquid medicine for standby by extraction according to the steps of the invention.

(2) Test drug preparation and use method

A. Decocting the traditional Chinese medicines: the Chinese herbal medicines are weighed according to the formula, mixed and crushed to prepare powder, and the amount of the powder is 2.5-3.0 g per chicken. The powder is wrapped with gauze, for the first time, the gauze wrapped powder is put into a pan (preferably a sand pot), simultaneously about 2 times of clear water is added, the powder is soaked for 30min, heated after boiling, turned over slow fire for 30min, cooled and filtered, and the liquid medicine is separated from the dregs for standby; and secondly, decocting the filtered dregs of a decoction into liquid medicine according to the first method, and mixing the decocted liquid medicines for standby.

B. Usage and dosage of experimental medicine

The traditional Chinese medicine comprises the following components: the decocted traditional Chinese medicine liquid is freely drunk by the chickens (about 4-8 mL/chicken. day), and the medicine residues are mixed with the feed and fed. The chickens which are seriously ill and do not drink water are drenched with a dropper for 1-2 mL each time and are fed for 3 times daily. The treatment dosage can be achieved by continuous use for 3-4 days. The preventive dose is reduced by half (about 2-4 mL/day), and the dregs are mixed with the feed and fed, so that the preventive dose can be reached after two days. Before administration, water is cut off for 2-5 h, and immune amino multivitamin is used in a matched manner.

Western medicines: the compound juenolone tablets are administrated by drenching 1 tablet per day for chicken and 2 tablets per day for big chicken, and are used for 2-3 days in combination with immune amino multivitamin mixed with water for drinking to achieve the treatment amount, and the prevention amount is reduced by half; the highly immune IBD yolk liquid is shaken well before use, is injected intramuscularly or subcutaneously, has 1mL of chicks and 2mL of big chickens, and can be drunk with immune amino multivitamin mixed with water to reach the treatment amount. The disease weight can be injected for 2-3 times repeatedly, and the prevention amount is reduced by half; the chicken infectious bursal disease live vaccine is diluted by 100mL of normal saline, and the vaccine is administrated by burette for immunization according to 0.2 mL/vaccine (two feathers).

1.2.3 groups of test animals

(1) Treatment comparison: 400 broilers of the Standy tiejiaoma were randomly selected from 21-day-old broilers, drenched with virulent suspension (0.2 ml per chicken), and then randomly divided into four groups (blank control group, Chinese medicinal composition treatment group of the invention, compound knoeveness treatment group, and refined high-immunity IBD yolk liquid treatment group), each group containing 100 broilers. Feeding with the same standard, administering according to the above usage and dosage, sampling on day 3, inspecting, diagnosing, and performing comparative treatment with corresponding medicine, the results are shown in Table 1.

TABLE 1 comparison of the Chinese medicinal composition of the present invention with western medicines and refined high-immunity IBD egg yolk antibody

Test group	Number of sick ducks	Death number (only)	Cure rate (%)
				Blank control group	100	100	0
Chinese medicinal composition	100	2	98
				Compound Juenong ketone group	100	55	45
Refined high-immunity IBD yolk liquid group	100	45	55

(2) And (3) prevention comparison: the three methods are used for prevention, and then the strong toxicity suspension is used for drenching, so as to count the infection rate (the chicken with the mental state and the drinking water state obviously worse than those before the strong toxicity infection is regarded as the infected chicken). 500 healthy chickens are randomly selected from 21-day-old spare tiejiaoma chick, and are randomly divided into 5 groups, namely a blank control group, a refined high-immunity IBD yolk liquid prevention group, a compound knoevenone prevention group, a Chinese medicinal composition group prevention group and a vaccine inoculation group (the prevention is carried out 3 days earlier than that of other groups). And (3) manually irrigating each group of chickens by 0.5 mL/chicken by using the prepared bursa of Fabricius virulent suspension on the fourth day after the administration of the medicine, forcibly infecting the chickens, counting infection results of the chickens after four days (see table 2), sampling, inspecting and diagnosing.

TABLE 2 statistics of infection rates of the Chinese medicinal composition of the present invention, western medicines, hyperimmune egg yolk antibody and vaccine for preventing artificial infection

Group of preventive tests	Duck group number (only)	Number of infection (only)	Infection Rate (%)
				Blank control group	100	100	100
Chinese medicinal composition	100	8	8
				Compound Juenong ketone group	100	63	63
High-immunity egg yolk liquid group	100	29	29
				Vaccinal group	100	45	45

2 results of the test

2.1 treatment comparison results of the Chinese medicinal composition group and the western medicines

As can be seen from Table 1, the cure rate of the traditional Chinese medicine composition group is 98%, and the cure rate is higher than that of the compound knoevenone group (45%) and the refined IBD egg yolk liquid group (55%), and all the blank control groups die. The results show that the treatment effect of the traditional Chinese medicine composition on the infectious bursal disease of chicken is obviously higher than that of the existing western medicine refined high-immunity IBD yolk liquid and compound knoeveness in market with better curative effect.

2.2 prevention and comparison results of the Chinese medicinal composition group and western medicines

As shown in Table 2, the infection rate of the group for preventing the Chinese medicinal composition of the invention is the lowest (8%), the group for preventing the refined high-immunity IBD yolk fluid is the second (29%), and the blank control group (without any medicament) is totally infected (100%). The infection rate of the Chinese medicinal composition prevention group is about 1/3 of an IBD egg yolk liquid prevention group, 1/8 of a compound knoeveness prevention group and 1/6 of a vaccination group.

3 analysis and discussion

3.1 the prevention and cure effect of the traditional Chinese medicine composition of the experimental formula is better than that of the comparative western medicine

3.1.1 according to the analysis of Chinese veterinary theory, the bursal disease is caused by the invasion of heat toxin. Heat is pathogenic yang, which tends to damage yin fluid, so it manifests as increased fluid desire; bleeding occurs in the muscles and other parts due to the bleeding caused by heat entering the blood system and blood circulation; the pathogenic heat transforms into fire to generate wind, and the wind helps the fire to disturb the mind upwards, so the sick chicken is in a faint state and does not feel refreshed; heat-toxicity scorches kidney yin, so it is manifested as kidney stone; the heat-toxin easily consumes body fluid and damages blood, thus causing exhaustion of origin, so the disease is acute and the death is fast.

According to the above syndrome differentiation, the treatment principles of purging fire for removing toxin, clearing heat and cooling blood should be taken, honeysuckle flower and radix isatidis are used for clearing heat and removing toxin, eliminating carbuncle and dissipating stagnation in the experimental formula, scutellaria baicalensis and golden cypress are used for clearing heat and drying dampness as main medicines, and dandelion is used for inducing diuresis for treating stranguria, clearing heat and reducing swelling; folium Isatidis, Gypsum Fibrosum, and Borneolum Syntheticum have effects of purging pathogenic fire, cooling blood, eliminating dampness, removing toxic substance, and enhancing the effect of principal drug, and herba Agastaches has effects of eliminating dampness and regulating stomach function, and are used as adjuvant drugs; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe. The combination of the medicines has good prevention and treatment effects (Liutao and Wang Rui, 2012). The traditional Chinese medicine has broad-spectrum bactericidal and antiviral effects, and some traditional Chinese medicines in the formula have inhibitory effects on staphylococcus aureus, escherichia coli and other germs besides viruses, and can strengthen the defense function of organisms, such as dandelion, honeysuckle and the like. Some of them can promote immunity and improve immunity, such as isatis root. The traditional Chinese medicine for preventing and treating the chicken infectious bursal disease can avoid the use of vaccine inoculation pollution, can avoid immunization failure, and can effectively prevent and treat other virus diseases and bacterial diseases.

3.1.2 Western medicines, refined high-immunity IBD yolk liquid from bursa of Fabricius and live vaccine for chicken infectious bursal disease only aim at infectious bursal disease, and have no effect on other viral diseases and bacterial diseases.

3.2 the Chinese medicinal composition has low prevention and treatment cost and convenient material acquisition.

Generally, the traditional Chinese medicine is sold in traditional Chinese medicine stores, the use method is simple and easy to operate, and the storage and the transportation are convenient. The traditional Chinese medicine formula can cure average flowers of 0.05-0.15 yuan for 1 chicken, while the refined high-immunity IBD yolk liquid is required to be used for treating the chicken, and the compound JunuoKe tablet is 0.8-1.6 yuan. The traditional Chinese medicine can be transported and stored at normal temperature, and is relatively high-temperature resistant, while the western medicine is relatively high in transportation and storage conditions, and especially the proper storage temperature of biological products such as refined high-immunity IBD yolk liquid is 4-8 ℃. The chicken infectious bursal disease live vaccine needs to be preserved by freezing. The traditional Chinese medicine composition is safe to use, western medicines need to be strictly controlled in dosage, the dosage is small and cannot achieve the effect, the dosage is large, poisoning and other conditions are easily caused, even a large number of deaths are caused, the requirements of biological products are higher, the medicines are easily polluted by the environment, and the environment is also polluted.

3.3 treatment based on syndrome differentiation

In conclusion, compared with western medicines for experiments, the traditional Chinese medicine composition has superiority in preventing and treating the infectious bursal disease of chicken. According to the experiences of penmen in raising chickens for more than twenty years, the traditional Chinese medicine composition has good treatment effect on the infectious bursal disease, but has certain limitation on prevention, and the protection period is short and is only about one week (the viewpoint is only used for reference). Therefore, the method proposes a Chinese and western medicine combination mode in the application of preventing and treating the infectious bursal disease of chicken. Generally, the chicken infectious bursal disease live vaccine is used for immunization, and the traditional Chinese medicine composition can be used for remedying the immune failure. Certainly, the method is used in chicken farms with better environmental conditions, no pollution and strict sanitation and disinfection. The traditional Chinese medicine is completely adopted for preventing and treating the infectious bursal disease of chicken, so that the chicken raising industry is more environment-friendly.

The traditional Chinese medicine decoction disclosed by the invention has the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, sterilizing and diminishing inflammation, can effectively treat the bursal disease of chicken, and solves the anxiety of farmers caused by related diseases easily caused by large-scale cultivation. In addition, the medicines used by the invention are all pure natural medicines, and repeated verification proves that the traditional Chinese medicine can effectively treat the bursal disease of chicken without toxic or side effect and adverse reaction.