阅读说明：本技术 一种治疗湿热兼阳虚型慢性湿疹的中药配方 (Traditional Chinese medicine formula for treating damp-heat and yang-deficiency type chronic eczema ) 是由 何彦生 于 2021-10-29 设计创作，主要内容包括：本发明公开了一种治疗湿热兼阳虚型慢性湿疹的中药配方,按重量份计,所述中药配方包括以下原料：麻黄8-10g、白术10-20g、苍术10-20g、连翘15-25g、赤小豆25-35g、制附子8-10g、细辛4-6g、龙胆草10-20g、白鲜皮15-25g、土茯苓20-40g、生地黄20-40g、当归10-30g、甘草10-14g、川芎10-14g、蜈蚣3-7g、僵蚕10-20g。本发明中药配方具有疏风散邪、健脾温肾、清热祛湿解毒、养阴、活血作用,暨祛邪又可抗过敏止痒；治疗方法方式多样,肺脾肝肾同治,标本兼治。谨守主要病机、结合疗程兼症组方,疗效确切；疗程短、费用低廉；无毒副作用,可制多种剂型,方便服用,值得推广使用。(The invention discloses a traditional Chinese medicine formula for treating damp-heat and yang-deficiency type chronic eczema, which comprises the following raw materials in parts by weight: 8-10g of ephedra, 10-20g of bighead atractylodes rhizome, 10-20g of rhizoma atractylodis, 15-25g of fructus forsythiae, 25-35g of phaseolus calcaratus, 8-10g of prepared monkshood, 4-6g of asarum, 10-20g of gentian, 15-25g of cortex dictamni, 20-40g of rhizoma smilacis glabrae, 20-40g of radix rehmanniae recen, 10-30g of angelica, 10-14g of liquorice, 10-14g of ligusticum wallichii, 3-7g of centipede and 10-20g of stiff silkworm. The traditional Chinese medicine formula has the effects of dispelling wind and eliminating evil, strengthening spleen and warming kidney, clearing heat, eliminating dampness, detoxifying, nourishing yin and activating blood, and can eliminate evil and resist allergy and relieve itching; the treatment methods are various, and the lung, spleen, liver and kidney can be treated simultaneously, thereby treating both the symptoms and root causes. The main pathogenesis is kept in mind, and the treatment course and symptom combination is combined, so that the curative effect is exact; short treatment course and low cost; has no toxic and side effects, can be prepared into various dosage forms, is convenient to take and is worth popularizing and using.)

1. The traditional Chinese medicine formula for treating damp-heat and yang-deficiency type chronic eczema is characterized by comprising the following raw materials in parts by weight: 8-10g of ephedra, 10-20g of bighead atractylodes rhizome, 10-20g of rhizoma atractylodis, 15-25g of fructus forsythiae, 25-35g of phaseolus calcaratus, 8-10g of prepared monkshood, 4-6g of asarum, 10-20g of gentian, 15-25g of cortex dictamni, 20-40g of rhizoma smilacis glabrae, 20-40g of radix rehmanniae recen, 10-30g of angelica, 10-14g of liquorice, 10-14g of ligusticum wallichii, 3-7g of centipede and 10-20g of stiff silkworm.

2. The traditional Chinese medicine formula for treating damp-heat and yang-deficiency type chronic eczema as claimed in claim 1, wherein the traditional Chinese medicine formula comprises the following raw materials: 9g of ephedra, 15g of bighead atractylodes rhizome, 15g of rhizoma atractylodis, 20g of fructus forsythiae, 30g of phaseolus calcaratus, 9g of prepared monkshood, 5g of asarum, 15g of gentian, 20g of cortex dictamni, 30g of rhizoma smilacis glabrae, 30g of radix rehmanniae recen, 20g of angelica sinensis, 12g of liquorice, 12g of ligusticum wallichii, 5g of centipede and 15g of stiff silkworm.

3. The traditional Chinese medicine formula for treating damp-heat and yang deficiency type chronic eczema as claimed in claim 1, wherein the traditional Chinese medicine formula is in the form of decoction, powder, pills or capsules.

Technical Field

The invention belongs to the technical field of traditional Chinese medicine formulas, and particularly relates to a traditional Chinese medicine formula for treating damp-heat and yang deficiency type chronic eczema.

Background

Eczema is a common allergic inflammatory skin disease, mainly immune damage mediated by T cells. Clinically, the skin lesions are characterized by skin lesion diversity, limited infiltration and hypertrophy of chronic skin lesions, acute subjective pruritus, easy repeated attack and the like. Chronic eczema is often caused by recurrent attack of acute eczema and subacute eczema, and chronic inflammation can be presented at the beginning. Chronic eczema is an inflammatory reaction involving the superficial dermis and epidermis, and belongs to one of the eczemas. The etiology is not well defined at present, but may be related to the interaction of various internal and external factors, such as infections, endocrine and metabolic disorders, blood circulation disorders, mental factors, food irritation, etc. The patients mainly show that the affected part has thick and rough skin and moss-like change, can be accompanied by discomfort such as pruritus and the like, have long course of disease and can seriously affect the life quality of the patients.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine formula for treating damp-heat and yang deficiency type chronic eczema.

In order to achieve the purpose, the technical scheme of the invention is as follows:

the traditional Chinese medicine formula for treating damp-heat and yang-deficiency type chronic eczema comprises the following raw materials in parts by weight: 8-10g of ephedra, 10-20g of bighead atractylodes rhizome, 10-20g of rhizoma atractylodis, 15-25g of fructus forsythiae, 25-35g of phaseolus calcaratus, 8-10g of prepared monkshood, 4-6g of asarum, 10-20g of gentian, 15-25g of cortex dictamni, 20-40g of rhizoma smilacis glabrae, 20-40g of radix rehmanniae recen, 10-30g of angelica, 10-14g of liquorice, 10-14g of ligusticum wallichii, 3-7g of centipede and 10-20g of stiff silkworm.

Preferably, the traditional Chinese medicine formula comprises the following raw materials: 9g of ephedra, 15g of bighead atractylodes rhizome, 15g of rhizoma atractylodis, 20g of fructus forsythiae, 30g of phaseolus calcaratus, 9g of prepared monkshood, 5g of asarum, 15g of gentian, 20g of cortex dictamni, 30g of rhizoma smilacis glabrae, 30g of radix rehmanniae recen, 20g of angelica sinensis, 12g of liquorice, 12g of ligusticum wallichii, 5g of centipede and 15g of stiff silkworm.

Preferably, the dosage form of the traditional Chinese medicine formula is decoction, powder, pills or capsules.

The nature, taste and efficacy of the raw materials are as follows:

herba ephedrae: nature and taste: pungent, slightly bitter and warm. Meridian tropism: it enters lung and bladder meridians. The functional indications are as follows: inducing sweat and dispelling cold, dispersing lung qi and relieving asthma, inducing diuresis and relieving swelling, and can be used for treating wind-cold type common cold, chest distress, cough, and edema due to wind-cold type; bronchial asthma. Ma Huang, sweet in moistening lung and relieving cough, is mostly indicated for exterior syndrome already relieved, asthma and cough.

White atractylodes rhizome: nature and taste: bitter, sweet and warm. Meridian tropism: it enters spleen and stomach meridians. The functional indications are as follows: invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis, arresting sweating, preventing miscarriage, and can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm and fluid retention, dizziness and palpitation, edema, spontaneous perspiration, and threatened abortion.

Rhizoma atractylodis: nature and taste: pungent, bitter and warm. Meridian tropism; it enters spleen, stomach and liver meridians. The functional indications are as follows: eliminating dampness and strengthening spleen, dispelling pathogenic wind and cold, improving eyesight, and can be used for treating abdominal distention, diarrhea, edema, tinea pedis, paralysis 36484m, rheumatalgia, wind-cold type common cold, and nyctalopia.

Fructus forsythiae: nature and taste: bitter and slightly cold. Meridian tropism: it enters lung, heart and small intestine meridians. The functional indications are as follows: clearing heat and detoxicating, and eliminating swelling and dissipating stagnation, and can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, fever, polydipsia, coma, macula, heat stranguria, and anuresis.

Small red beans: nature and taste: sweet, sour and neutral. Meridian tropism: it enters heart and small intestine meridians. The functional indications are as follows: induce diuresis to alleviate edema, remove toxicity and expel pus; can be used for treating edema, swelling, tinea pedis, edema of limbs, jaundice, dark urine, rheumatism, pyretic arthralgia, carbuncle, suppurative sore, intestinal carbuncle, and abdominal pain.

Preparing monkshood: nature and taste: pungent and sweet with big heat and toxicity. Meridian tropism: it enters heart, kidney and spleen meridians. The functions and indications are as follows: restoring yang, relieving collapse, invigorating fire, tonifying yang, and expelling pathogenic wind, cold and dampness; can be used for treating yang exhaustion, collapse, cold limbs, slight pulse, sexual impotence, cold womb, psychroalgia of heart and abdomen, vomiting and diarrhea due to deficiency-cold, edema due to yin-cold, affection of exogenous pathogenic factor due to yang deficiency, and arthralgia due to cold-dampness.

Asarum: nature and taste: pungent and warm. Meridian tropism: it enters heart, lung and kidney meridians. The functional indications are as follows: dispel wind and cold, induce resuscitation and alleviate pain, warm lung and resolve retained fluid. Can be used for treating wind-cold type common cold, headache, toothache, nasal obstruction, nasosinusitis, rheumatalgia, phlegm retention, asthma, and cough.

Gentian: nature and taste: bitter and cold. Meridian tropism: it enters liver and gallbladder meridians. The functional indications are as follows: clearing heat and drying dampness, and purging liver and gallbladder fire; can be used for treating damp-heat jaundice, yin swelling, pudendal pruritus, leukorrhagia, middle-jiao strengthening, eczema, pruritus, conjunctival congestion, deafness, hypochondriac pain, bitter taste in mouth, and convulsion.

And (3) preparing cortex dictamni: nature and taste: bitter and cold. Meridian tropism: spleen, stomach and bladder meridians. The functional indications are as follows: damp-heat sores, yellow water dripping, eczema, rubella, scabies, tinea, scabies, sores, scabies and arthralgia due to wind-damp-heat.

Glabrous greenbrier rhizome: nature and taste: sweet, bland and mild. Meridian tropism: it enters liver and stomach meridians. The functional indications are as follows: remove dampness, remove toxicity, and relieve joint pain. Can be used for treating damp-heat stranguria with turbid discharge, leukorrhagia, carbuncle swelling, scrofula, scabies, tinea, syphilis and limb spasm and arthralgia and myalgia caused by mercury poisoning.

Dried rehmannia root: nature and taste: sweet and cold in nature. Meridian tropism: it enters heart, liver and kidney meridians. The functional indications are as follows: clear heat and cool blood, nourish yin, promote the production of body fluid. Can be used for treating fever with deep-red tongue, polydipsia, yin deficiency, internal heat, bone steaming, internal heat, diabetes, hematemesis, epistaxis, macula, and eruption.

Chinese angelica: nature and taste: sweet, pungent and warm. Meridian tropism: it enters liver, heart and spleen meridians. The functional indications are as follows: enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease.

Licorice root: nature and taste: sweet and neutral. Meridian tropism: it enters heart, lung, spleen and stomach meridians. The functional indications are as follows: invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the above medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Ligusticum wallichii: nature and taste: pungent and warm. Meridian tropism: it enters liver, gallbladder and pericardium meridians. The functional indications are as follows: promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.

Centipede: nature and taste: pungent and warm; is toxic. Meridian tropism: it enters liver meridian. The functional indications are as follows: extinguish wind and relieve spasm, remove pathogen and resolve accumulation, dredge collaterals and alleviate pain. Can be used for treating infantile convulsion, spasm, facial distortion due to apoplexy, hemiplegia, tetanus, rheumatism, suppurative sore, lymphoid tuberculosis, and venomous snake bite.

Stiff silkworm: nature and taste: salty, pungent and even. Meridian tropism: it enters liver, lung and stomach meridians. The functional indications are as follows: dispelling pathogenic wind, arresting convulsion, eliminating phlegm, and resolving masses; can be used for treating convulsion, sore throat, skin pruritus, submandibular lymphadenitis, and facial paralysis.

The pharmaceutical mechanism of the formula of the invention is as follows: the ephedra, the forsythia and the red bean soup clear heat and promote diuresis, dispel exogenous pathogenic factors and clear interior heat, imitate the effect of the zhangzhongjing ephedra, forsythia and red bean soup, researches show that the ephedra, forsythia and red bean soup has obvious pharmacological effects of resisting allergy and relieving itching, can effectively improve the symptoms of pruritus and exudation of eczema patients, and meanwhile, the monkshood and asarum soup is used for warming (spleen and kidney) to tonify yang, and dampness is yin pathogen to obtain yang to transform, so that the body resistance is strengthened to eliminate pathogenic factors, and the body resistance is eliminated without damaging the body resistance. The study suggests that the ephedra, monkshood and asarum decoction can play an anti-allergic effect by inhibiting a cytokine IL4 for inducing IGE generation.

The formula is matched with wind-medicine, namely Chinese ephedra, stiff silkworm and asarum to strengthen and promote pathogenic toxin to emerge from the exterior; the atractylodes macrocephala koidz strengthens qi of lung and spleen to promote diuresis, and the atractylodes lancea koidz strengthens spleen to eliminate dampness and enhances the immunity of organisms; semen Phaseoli and radix Gentianae have effects of eliminating dampness, clearing away heat and toxic materials, discharging damp toxin from urine, and cortex Dictamni Radicis has effects of clearing heat, eliminating dampness, removing toxic materials and relieving itching; large dose of prepared rhizome of rehmannia cools blood and nourishes yin, balances the bitter and cold properties of the dittany bark and the gentian which injures yin; radix rehmanniae, angelica and rhizoma ligustici wallichii are used for activating and nourishing blood, and the blood circulation and the wind circulation are self-extinguished; licorice, red bean and glabrous greenbrier rhizome. Bombyx Batryticatus and Scolopendra have effects of dispelling pathogenic wind, dredging collaterals, removing toxic substance and relieving itching.

The compatibility of the prescription is characterized in that: 1. the use of a large amount of wind-evil medicines strengthens the effects of eliminating evil, promoting blood circulation, clearing heat, eliminating dampness, detoxifying and the like; 2. the formula is used for treating the chronic eczema mainly caused by damp-heat and yang deficiency, and adopts a method of dispelling wind and eliminating evil, tonifying spleen and warming kidney, clearing heat, eliminating dampness and detoxifying, nourishing yin and invigorating blood circulation, and the method can eliminate evil and resist allergy and relieve itching; the treatment methods are various, and the lung, spleen, liver and kidney can be treated simultaneously, thereby treating both the symptoms and root causes. 3. For the disease, the dampness is not harmony, only 2 bitter and dry dittany bark and gentian are used for dampness elimination, and a large amount of radix rehmanniae is used for preventing yin damage, so that the emphasis is placed on balancing dampness elimination.

Has the advantages that: the traditional Chinese medicine formula provided by the invention keeps the main pathogenesis in mind, combines the treatment course and the symptom formula and has definite curative effect; short treatment course and low cost; has no toxic and side effects, can be prepared into various dosage forms, is convenient to take and is worth popularizing and using.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.

Embodiment 1, a traditional Chinese medicine formula for treating damp-heat and yang deficiency type chronic eczema comprises the following raw materials in parts by weight: 9g of ephedra, 15g of bighead atractylodes rhizome, 15g of rhizoma atractylodis, 20g of fructus forsythiae, 30g of phaseolus calcaratus, 9g of prepared monkshood, 5g of asarum, 15g of gentian, 20g of cortex dictamni, 30g of rhizoma smilacis glabrae, 30g of radix rehmanniae recen, 20g of angelica sinensis, 12g of liquorice, 12g of ligusticum wallichii, 5g of centipede and 15g of stiff silkworm. 1 dose daily, 600ml of water is decocted in the morning, at noon and at night, 200ml of the decoction is orally taken once. A treatment course is 30 days, and the curative effect is observed after 1 treatment course.

Clinical observations

1. Observation object

The patients were enrolled in 55 patients, 28 patients, 11 men, 17 women, age (41.61 + -17.48) years, course (3.28 + -4.38) years; the control group had 27 cases, 13 cases for men and 14 cases for women, aged (45.56 + -16.59) and had a course of disease (2.99 + -3.60) years. The treated group and the control group have no difference before treatment in terms of sex, age, disease course, eczema major symptoms and Chinese medical symptom score (P is more than 0.05), and have comparability.

2. Inclusion criteria

(1) The diagnosis standard of western medicine for chronic eczema and the diagnosis standard of yang deficiency and damp heat syndrome type of traditional Chinese medicine are met; (2) the age is 18-65 years old; (3) agreeing to participate in clinical trial observation, signing an informed consent and matching with a therapist; (4) the rash is primary rash and is unrelated to occupational factors; (5) the medicine for treating the disease is not used before the treatment or is stopped within 10 days before the treatment.

3. Method of treatment

The traditional Chinese medicine is based on the example 1 on the basis of conventional nursing and symptomatic support treatment. Providing and preparing traditional Chinese medicines: beijing Kanrenttang Co., Ltd provides full-ingredient Chinese medicinal granules. The taking method comprises the following steps: making into powder, pill or capsule. It is administered 3 times daily, 10g each time.

On the basis of conventional treatment, cetirizine hydrochloride tablets are taken once a day, 10mg a day and warm water, and are taken once before sleep at night. The treatment course is two weeks.

4. Observation index

(1) The clinical cure is as follows: the skin lesions are completely removed, the symptoms disappear, and the integral value is reduced to 90%; (2) the effect is shown: the skin lesions are mostly removed, the symptoms are obviously relieved, and the integral value is reduced by more than 70 percent; (3) the method has the following advantages: the skin lesion is partially removed and the skin lesion,

symptoms improved, with a reduction in score of 50%; (4) and (4) invalidation: the skin lesions did not resolve significantly, symptoms were not reduced or worsened adversely, and the score decreased by < 50%. The treatment efficacy determination time was after the 2 nd week of clinical observation.

5. Therapeutic results

Table 1: the overall curative effect of the two groups of damp-heat and yang deficiency type chronic eczema patients is compared.

TABLE 1 comparison of the overall therapeutic effects of damp-heat and yang-deficiency type chronic eczema patients

Table 2: comparing the forms of skin lesions (EASI) of two groups of damp-heat and yang deficiency type chronic eczema patients.

Table 2 comparison of EASI scores of skin lesion morphology of chronic eczema with damp-heat and yang deficiency

Table 3: and the percentage of eosinophils of the two groups of damp-heat and yang deficiency type chronic eczema patients is compared.

TABLE 3 comparison of therapeutic effect before and after eosinophil percentage treatment for two groups of damp-heat and yang deficiency type chronic eczema patients

Note: the Wilcoxon rank sum test is carried out.

Table 4: and comparing the IGE of the two groups of damp-heat and yang deficiency type chronic eczema patients.

TABLE 4 comparison of the curative effects before and after treatment of two groups of patients with chronic eczema due to damp-heat and yang deficiency

The treatment group is cured for 7 cases, the effective treatment group is 10 cases, the effective treatment group is 7 cases, the ineffective treatment group is 4 cases, the total effective rate is 85.71%, the control group is cured for 3 cases, the effective treatment group is 10 cases, the ineffective treatment group is 11 cases, and the total effective rate is 59.26%.