阅读说明：本技术 双重血浆分子吸附系统的控制方法、设备及存储介质 (Control method and device of dual plasma molecular adsorption system and storage medium ) 是由 董凡 刘冠贤 吴文娟 于 2021-08-20 设计创作，主要内容包括：本申请公开了一种双重血浆分子吸附系统的控制方法、血液净化设备及存储介质,该方法包括：根据人体血液中的血浆占比和血浆分离器的分离系数,确定速率比例范围,速率比例范围是血液回路的第一流速与血浆旁流支路的第二流速之间的比例范围；根据患者的生理特征参数,确定血液回路的第一流速；根据第一流速和所述速率比例范围,确定血浆旁流支路的第二流速。通过这种方式,能够自动确定血液回路的流速和血浆旁流支路的流速,且两者流速之间的速率比例范围合理,提高血浆分离效率、治疗效率和安全性,尤其适用于DPMAS。(The application discloses control method, blood purification equipment and storage medium of dual plasma molecular adsorption system, and the method comprises the following steps: determining a rate ratio range according to the plasma ratio in the human blood and the separation coefficient of the plasma separator, wherein the rate ratio range is a ratio range between a first flow rate of the blood circuit and a second flow rate of the plasma bypass branch; determining a first flow rate of the blood circuit based on a physiological characteristic parameter of the patient; and determining a second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range. By the mode, the flow speed of the blood circuit and the flow speed of the plasma bypass branch can be automatically determined, the speed ratio range between the flow speeds is reasonable, the plasma separation efficiency, the treatment efficiency and the safety are improved, and the method is particularly suitable for DPMAS.)

1. A method of controlling a blood purification apparatus comprising a blood circuit, a plasma separator and a plasma bypass, the method comprising:

determining a rate ratio range, which is a ratio range between a first flow rate of the blood circuit and a second flow rate of the plasma bypass branch, according to a plasma ratio in human blood and a separation coefficient of the plasma separator;

determining a first flow rate of the blood circuit based on a physiological characteristic parameter of a patient;

and determining a second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range.

2. The method of claim 1, wherein after determining the first flow rate of the blood circuit based on the physiological characteristic parameter of the patient, further comprising:

controlling the first flow rate to increase or decrease according to the detected first flow rate adjusting operation of the user;

displaying the increased or decreased first flow rate on a display screen of the blood purification apparatus.

3. The method of claim 2, wherein said controlling said first flow rate to increment or decrement comprises:

and controlling the first flow rate to increase or decrease according to a preset step length.

4. The method of claim 2, wherein said determining a second flow rate of said plasma bypass branch based on said first flow rate and said range of rate ratios comprises:

and determining the adjusted second flow rate of the plasma bypass branch according to the increased or decreased first flow rate and the rate ratio range.

5. The method of claim 2, wherein said controlling said first flow rate to increment or decrement based on a detected first flow rate adjustment operation by a user comprises:

and when the current first flow rate is determined to be in the flow rate adjustable range of the blood circuit, controlling the first flow rate to be increased or decreased according to the detected first flow rate adjusting operation of the user.

6. The method of claim 1, wherein said determining a second flow rate of said plasma bypass branch based on said first flow rate and said range of rate ratios comprises:

determining a rate scaling value in said rate scaling range;

and determining a second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio value.

7. The method of claim 6, further comprising:

re-determining a rate scaling value in said rate scaling range in response to a detected second flow rate adjustment operation by the user;

said determining a second flow rate of said plasma bypass branch based on said first flow rate and said rate ratio value comprises:

and determining the adjusted second flow rate of the plasma bypass branch according to the first flow rate and the re-determined rate ratio value.

8. The method of claim 1, further comprising:

recording the blood flow time of the blood circuit;

when the blood flowing time reaches a first preset time, controlling the plasma in the plasma bypass branch to stop flowing;

the normal saline is input into the blood circuit, the normal saline in the blood circuit is controlled to flow according to a third flow rate so as to carry out blood returning on the blood circuit, and the blood returning time of the blood circuit is recorded;

when the blood return time of the blood circuit reaches a second preset time, controlling the physiological saline in the blood circuit to stop flowing;

the normal saline is conveyed to the plasma bypass flow branch, and the normal saline in the plasma bypass flow branch is controlled to flow at a fourth flow rate so as to carry out blood return on the plasma bypass flow branch;

wherein the first flow rate is greater than the third flow rate and the second flow rate is greater than the fourth flow rate.

9. A blood purification apparatus comprising a blood circuit, a plasma separator and a plasma bypass, characterized in that the blood purification apparatus further comprises a memory for storing a computer program and a processor; the processor is configured to execute the computer program and, when executing the computer program, implement the control method of the blood purification apparatus according to any one of claims 1 to 8.

10. A computer-readable storage medium, characterized in that a computer program is stored which, when executed by a processor, causes the processor to implement the method of controlling a blood purification apparatus according to any one of claims 1 to 8.

Technical Field

The present application relates to the field of blood purification technology, and in particular, to a method for controlling a blood purification apparatus, and a storage medium.

Background

Clinically, the treatment mode using a Dual Plasma Molecular Adsorption System (DPMAS) requires setting the flow rates of the respective fluids in the line, such as setting the flow rate of blood and the flow rate of Plasma.

In the conventional technique, when controlling the flow rate of the fluid in the blood purification line, only the maximum alarm value of the flow rate is specified. The specific value of the flow rate of the fluid in the pipeline is usually dependent on the experience of the medical staff as long as the value is below the maximum alarm value. Such manual setting can lead to improper setting of the flow rate, particularly the ratio between the flow rate of blood and the flow rate of plasma, which can easily reduce the efficiency of the DPMAS treatment and even endanger the safety of the patient during the DPMAS treatment.

Disclosure of Invention

Based on this, the present application provides a control method of a blood purification apparatus, and a storage medium.

In a first aspect, the present application provides a method of controlling a blood purification apparatus comprising a blood circuit, a plasma separator and a plasma bypass, the method comprising:

determining a rate ratio range, which is a ratio range between a first flow rate of the blood circuit and a second flow rate of the plasma bypass branch, according to a plasma ratio in human blood and a separation coefficient of the plasma separator;

determining a first flow rate of the blood circuit based on a physiological characteristic parameter of a patient;

and determining a second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range.

In a second aspect, the present application provides a blood purification apparatus comprising a blood circuit, a plasma separator and a plasma bypass, the blood purification apparatus further comprising a memory for storing a computer program and a processor; the processor is configured to execute the computer program and, when executing the computer program, implement the control method of the blood purification apparatus as described above.

In a third aspect, the present application provides a computer-readable storage medium storing a computer program which, when executed by a processor, causes the processor to implement the control method of a blood purification apparatus as described above.

The embodiment of the application provides a control method of blood purification equipment, the blood purification equipment and a storage medium, wherein a speed ratio range is determined according to a plasma ratio in human blood and a separation coefficient of a plasma separator, and the speed ratio range is a ratio range between a first flow speed of a blood circuit and a second flow speed of a plasma bypass branch; determining a first flow rate of the blood circuit based on a physiological characteristic parameter of the patient; and determining a second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range. Compared with the prior art, the flow rate in the blood circuit and the flow rate in the plasma bypass branch circuit need to be manually set, the speed ratio range can be determined according to the plasma proportion in human blood and the separation coefficient of the plasma separator, the first flow rate of the blood circuit can be reasonably determined according to the physiological characteristic parameters of a patient, and then the second flow rate of the plasma bypass branch circuit can be automatically determined according to the first flow rate and the speed ratio range; the first flow rate and the second flow rate can be automatically determined and set without manual setting; the first flow rate and the second flow rate are determined without depending on the experience of medical staff, and the determination modes of the two flow rates are reasonable; the range of rate ratios between the first flow rate and the second flow rate is also determined in a very rational manner; therefore, the efficiency of the plasma separator for separating the plasma can reach the highest, the safety of blood transmission in the plasma separation process can be guaranteed, and the treatment efficiency and safety of the DPMAS can be improved.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.

Drawings

Fig. 1 is a schematic view of a treatment principle of an embodiment of a DPMAS treatment mode in the control method of the blood purification apparatus of the present application;

FIG. 2 is a schematic flow chart illustrating an embodiment of a method for controlling a blood purification apparatus according to the present application;

FIG. 3 is a schematic diagram of an embodiment of a treatment parameter interface in the control method of the blood purification apparatus of the present application;

FIG. 4 is a diagram illustrating an embodiment of a pop-up parameter setting window on a display screen in the control method of the blood purification apparatus according to the present application;

fig. 5 is a schematic structural diagram of an embodiment of the blood purification apparatus of the present application.

Description of the main elements and symbols:

100. a host; 200. a memory; 300. a processor;

1. arterial line, 2, venous line, 3, plasma separator; 4. a blood pump; 5. a heparin pump; 6. a venous pot; 7. a plasma adsorption branch; 8. a heparin output branch; 9. a slurry distributing pump; 10. a gas trapping pot; 11. an anion resin adsorber; 12. a neutral macroporous resin adsorber; 13. a plasma bypass branch; 14. a blood circuit.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some, but not all, embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

The flow diagrams depicted in the figures are merely illustrative and do not necessarily include all of the elements and operations/steps, nor do they necessarily have to be performed in the order depicted. For example, some operations/steps may be decomposed, combined or partially combined, so that the actual execution sequence may be changed according to the actual situation.

The control method of the blood purification apparatus of the embodiment of the present application is applicable to a treatment mode in which plasma and a liquid containing blood cells are separated by a plasma separator, for example: a DPMAS treatment modality, a Double plasma replacement (DFPP) treatment modality, and the like. Before describing the control method of the blood purification apparatus of the embodiment of the present application in detail, one of DPMAS treatment modes to which the method of the embodiment of the present application can be applied will be described.

Referring to fig. 1, fig. 1 is a schematic view of a treatment principle of an embodiment of a DPMAS treatment mode in the control method of the blood purification apparatus of the present application.

The Double Plasma Molecular Adsorption System (DPMAS) therapeutic model is widely used in clinical application. The components of the circuit for DPMAS treatment mode include: an arterial line 1, a venous line 2, a plasma separator 3, a blood pump 4, a heparin pump 5, a venous pot 6, a plasma adsorption branch 7, a heparin output branch 8, a plasma pump (or a plasma pump) 9, an air trap pot 10, an anion resin adsorber 11 (such as a BS330 bilirubin adsorber), and a neutral macroporous resin adsorber 12 (such as an HA330-II disposable blood perfusion apparatus). The DPMAS treatment mode is characterized in that a neutral macroporous resin adsorber 12 is connected in series on the basis of the existing blood adsorption system, a blood pump 4 is arranged on a blood loop (comprising an arterial line 1 and a venous line 2), the blood pump 4 provides driving force for the blood loop by controlling the operation of the blood pump 4, the blood loop transmits the blood of a human body from the artery of the human body to a plasma separator 3, the plasma separator 3 separates the blood of the human body into plasma and liquid containing blood cells, a plasma separation pump 9 is arranged on a plasma adsorption branch 7, the plasma separation pump 9 provides driving force for the plasma adsorption branch 7 by controlling the operation of the plasma separation pump 9, the plasma separated by the plasma separator 3 is sequentially sent to an anionic resin adsorber 11 and the neutral macroporous resin adsorber 12 by the plasma adsorption branch 7, then the liquid containing the blood cells and the plasma after adsorption are mixed and then returned to the vein of the human body, to complete the DPMAS treatment process.

The DPMAS treatment mode is used as one of artificial livers, bilirubin and middle-molecular toxins can be specifically adsorbed under the condition of plasma deficiency, jaundice can be rapidly cleared, and meanwhile a large amount of toxins and inflammation media can be rapidly removed, so that the effect of treating both symptoms and root causes is achieved; after the DMPAS treatment mode is used for multiple times of clinical treatment, the DMPAS treatment mode is widely popularized in the clinical field by virtue of excellent treatment effect, and the DMPAS treatment mode can improve the treatment success rate and improve the recovery of patients.

It should be noted that the plasma pump 9 is used for controlling the plasma flow rate in the plasma absorption branch 7, and the blood pump 4 is used for controlling the blood flow rate in the blood circuit, wherein the plasma pump 9 and the blood pump 4 belong to peristaltic pumps, and the control principle of the plasma pump 9 and the blood pump 4 is not described redundantly.

In addition, reference will be made hereinafter to: controlling the flow rate of the blood circuit and the flow rate of the plasma adsorption branch; the control of the flow rate of the blood circuit is realized by controlling the rotating speed of the blood pump, and the rotating speed of the blood pump and the flow rate of the blood circuit have a corresponding relation; the 'controlling the flow rate of the plasma adsorption branch' is realized by controlling the rotating speed of the plasma separating pump, and the rotating speed of the plasma separating pump and the flow rate of the plasma adsorption branch have a corresponding relation.

Referring to fig. 2, fig. 2 is a schematic flow chart of an embodiment of the control method of the blood purification apparatus of the present application. The blood purification apparatus of the embodiments of the present application includes a blood circuit, a plasma separator, and a plasma bypass branch. The blood circuit includes an arterial line and a venous line. The plasma separator separates the blood in the blood circuit into plasma and liquid containing blood cells, the plasma is treated by other devices (such as a plasma adsorption device) along the plasma bypass flow branch and then returned to the human body, and the liquid containing the blood cells is returned to the human body along the blood circuit.

The method comprises the following steps: step S101, step S102, and step S103.

Step S101: determining a rate ratio range, which is a ratio range between a first flow rate of the blood circuit and a second flow rate of the plasma bypass branch, according to a plasma ratio in the human blood and a separation coefficient of the plasma separator.

Human blood includes plasma and blood cells according to its basic composition. The effects of plasma are mainly: carrying blood cells, transporting substances required for maintaining human life activities and wastes generated in vivo, etc. The ratio of plasma in human blood is about 55-60%; for people of different ages and constitutions, the proportion of plasma in blood varies slightly, and generally does not exceed the range of 55-60%.

The plasma separator is used for separating plasma from blood of a human body; the plasma separator mainly comprises: hollow fiber membranes and the like; when the blood of the human body is transferred to the hollow fiber membrane, plasma and blood cells are separated from the blood of the human body using the hollow fiber membrane having a pore size of a specific size. Thus, the separation factor of a plasma separator may refer to: the ratio of the screened plasma to the total plasma amount is determined after the plasma in the blood flows through the plasma separator in unit time.

Taking the DPMAS treatment mode shown in fig. 1 as an example, the blood purification apparatus in the DPMAS treatment mode further includes a plasma adsorption device, and the plasma bypass branch is a plasma adsorption branch. Wherein, the plasma adsorption device can comprise an anion resin adsorber and a neutral macroporous resin adsorber. The blood circuit comprises: the blood plasma absorption device comprises an arterial pipeline and a venous pipeline, wherein after blood is transmitted to a plasma separator through the arterial pipeline, plasma separated by the plasma separator is transmitted to a plasma absorption branch, and liquid containing blood cells after separation is transmitted to the venous pipeline. For example, within 1 minute, 1L of plasma flows through the plasma separator, and a total of 0.5L of plasma is separated, the separation factor is 50%.

The separation coefficient can represent the screening performance of the plasma separator on plasma; generally, the larger the separation coefficient, the higher the screening performance of the plasma separator on plasma. In practical application, the separation coefficient of the plasma separator depends on the physical and chemical properties of the hollow fiber membrane, such as the material and the number of the hollow fiber membranes. Plasma separators made by different manufacturers also have relatively large differences, and therefore plasma separators made by different manufacturers have a specific separation coefficient.

The present embodiment sets the rate ratio range in accordance with the properties of human blood (i.e., plasma ratio) and the properties of the plasma separator (i.e., separation coefficient). Wherein the rate ratio range may refer to: a range of ratios between a first flow rate of the blood circuit and a second flow rate of the plasma bypass branch. This rate ratio range can be considered as an optimal ratio range between the first flow rate and the second flow rate, which when within this rate ratio range can just ensure that: when the blood flows through the plasma separator at a certain speed, the plasma separator can separate the plasma from the blood at an optimal speed, and the plasma separation efficiency of the plasma separator is in an optimal range.

Wherein, the ratio of the blood plasma in the blood of the human body and the separation coefficient of the blood plasma separator can have a corresponding relation with the rate ratio range, and the corresponding relation can be directly obtained according to the clinical experiment of medical staff. For example, table 1 below shows the correspondence between the plasma ratio in human blood, the separation coefficient of the plasma separator, and the rate ratio range.

TABLE 1 correspondence between plasma ratio, separation coefficient, and rate ratio range

Ratio of blood plasma	Coefficient of separation	Range of rate ratios
			55％	50％	1.43～1.45
56％	50％	1.09～1.11
			57％	40％	1.18～1.21
58％	40％	1.25～1.28
			59％	30％	1.67～1.71
60％	30％	1.98～2.00

It should be noted that the data in table 1 are only for example, and it is not meant that the data are actually used in clinic.

In step S101, the rate ratio range belongs to a range, and a specific value can be selected within the rate ratio range, as long as any value within the rate ratio range can ensure that: the plasma separator achieves optimal screening performance for plasma in human blood as the blood flows through the plasma separator.

Step S102: a first flow rate of the blood circuit is determined based on a physiological characteristic parameter of a patient.

The physiological characteristic parameter of the patient may refer to a physiological characteristic parameter associated with the patient, including but not limited to: sex, age, weight, number of previous treatments (e.g., number of previous DPMAS treatments), total time of previous treatments (e.g., total time of previous DPMAS treatments), etc. of the patient. The physiological characteristic parameters represent the actual physiological characteristics of the patients, and the parameters in the treatment process are convenient to change in real time according to the physiological characteristic parameters of the patients.

The blood purification apparatus may have stored therein physiological characteristic parameters of the patient. If the physiological characteristic parameter of the patient is not available in the blood purification apparatus, the physiological characteristic parameter of the patient needs to be acquired before step S102. One common way in which physiological characteristic parameters of a patient are obtained is: a user input of a physiological characteristic parameter of a patient is received. For example, the blood purification apparatus may further include: the display screen is used for receiving an operation instruction of a medical worker and carrying out information interaction; when medical personnel trigger a physiological characteristic parameter input event of a patient on an interface of a display screen, the display screen is controlled to display a parameter input interface, and the medical personnel can input the physiological characteristic parameter of the patient on the parameter input interface.

The first flow rate of the blood circuit may refer to a flow rate of a fluid of the blood circuit; the fluid in the blood circuit is typically different in different lines of the blood circuit and may be collectively referred to as blood, and thus the first flow rate of the blood circuit may be referred to as the blood flow rate of the blood circuit.

The physiological characteristic parameter of the patient corresponds to the first flow rate of the blood circuit. Generally, according to clinical trials, the healthier the physiological characteristics of the patient, the faster the blood flow rate in the blood circuit can be set to accelerate the rate of treatment; conversely, the weaker the physiological characteristics of the patient, the slower the blood flow rate in the blood circuit can be set (because if the blood flow rate is too fast, it will cause excessive pressure in the veins and arteries of the patient, which may damage the patient's health). Therefore, in step S102, a first flow rate is determined according to the physiological characteristic parameter of the patient, and then the blood in the blood circuit is controlled to flow at the first flow rate.

In step S102, the first flow rate of the blood circuit is determined according to the physiological characteristic parameter of the patient, and the source of the first flow rate may be obtained by accumulating big data of clinical treatment experience of qualified medical staff, and the data is stored in the machine for reference when the medical staff actually uses the data. For example, the physiological characteristic parameters of the patient include: the weight of the patient; the blood volume of a human body accounts for the weight of the human body and is generally as follows: 7% -8%, for the patient that weighs fatter, the human blood volume can be bigger, and medical personnel can set the first flow rate of blood circuit as big as possible. As another example, the physiological characteristic parameters of the patient include: the age of the patient; for the patient with the older age, the pressure value which can be born by the blood vessel of the patient is smaller, and the medical staff can set the first flow rate of the blood circuit as small as possible so as to ensure the treatment safety of the patient with the older age.

In step S102, the first flow rate of the blood circuit is determined according to the physiological characteristic parameter of the patient, and the first flow rate can also be derived from identifying the patient and reading the blood flow rate of the patient history.

Therefore, when the physiological characteristic parameters of the patient are obtained, the first flow rate can be set in a reasonable range according to the physiological characteristic parameters of the patient, the safety of the patient during treatment can be guaranteed, the dependence of the first flow rate on the experience of medical staff can be eliminated, the first flow rate which is suggested is directly provided by equipment for the medical staff to refer to, and the treatment efficiency can be improved.

It should be noted that step S101 and step S102 have no obvious sequence.

Step S103: and determining a second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range.

The second flow rate of the plasma bypass branch may be determined with both the first flow rate and the rate ratio range determined.

For example, the first flow rate is: 50ml/min, rate ratio range: 1.67-1.71, the second flow rate can be calculated by the following formula: 50/(1.67-1.71) ml/min is (29.24-29.94) ml/min, and then any value can be selected as the second flow rate in (29.24-29.94) ml/min.

In the traditional technology, when the flow rate of the liquid in the pipeline for purifying the blood is controlled, only the maximum alarm value of the flow rate is specified, and the specific value of the flow rate of the liquid in the pipeline is only dependent on the experience of medical personnel under the maximum alarm value, so that the manual setting mode can cause the unreasonable setting of the flow rate, particularly the unreasonable setting of the ratio between the flow rate of the blood and the flow rate of the blood plasma; if the flow rate of the plasma is higher than the plasma separation speed of the plasma separator, insufficient plasma separation in the blood can be caused, the pressure difference between two sides of the plasma separator is too large, blood components such as blood cells in the blood can be damaged, or a separation membrane in the plasma separator can be damaged; if the flow rate of the plasma is less than the plasma separation speed of the plasma separator, the plasma separated by the plasma separator cannot enter the plasma bypass branch in time, and the efficiency of blood purification treatment is reduced; and depends on the working experience of medical staff, thus being not friendly to users.

The embodiment of the application can determine the rate proportion range according to the plasma proportion in the human blood and the separation coefficient of the plasma separator, reasonably determine the first flow rate of the blood loop according to the physiological characteristic parameters of the patient, and then automatically determine the second flow rate of the plasma bypass branch according to the first flow rate and the rate proportion range; the first flow rate and the second flow rate can be automatically determined and set without manual setting; the first flow rate and the second flow rate are determined without depending on the experience of medical staff, and the determination modes of the two flow rates are reasonable; the range of rate ratios between the first flow rate and the second flow rate is also determined in a very rational manner; therefore, the efficiency of the plasma separator for separating the plasma can reach the highest, the safety of blood transmission in the plasma separation process can be guaranteed, and the treatment efficiency and the safety can be improved.

The blood purification apparatus typically has a display screen, and in one embodiment, after the first flow rate is determined, the first flow rate can be displayed on the display screen for easy viewing by the medical personnel. After the step S102 of determining the first flow rate of the blood circuit according to the physiological characteristic parameter of the patient, the method may further include: a display screen of the blood purification apparatus is controlled to display a treatment parameter interface including the first flow rate, as shown in fig. 3.

Likewise, after the second flow rate is determined, the second flow rate may also be displayed on a display screen for easy viewing by medical personnel. After the step S103 of determining the second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range, the method may further include: controlling the display screen to display a treatment parameter interface including a second flow rate, as shown in fig. 3.

Thus, the medical personnel can see the treatment parameter interface at any time, and see the first flow rate and the second flow rate. The flow rate of the blood circuit can be reset according to the current first flow rate (namely, the first flow rate is adjusted), and the second flow rate of the plasma bypass branch can be reset according to the second flow rate (namely, the second flow rate is adjusted), so that the operation of medical staff is facilitated.

In an embodiment, after determining the first flow rate, the first flow rate may also be adjusted according to the user's needs. Namely, step S102, after determining the first flow rate of the blood circuit according to the physiological characteristic parameter of the patient, the method may further include: step S104 and step S105.

Step S104: and controlling the first flow rate to be increased or decreased according to the detected first flow rate adjusting operation of the user.

In this embodiment, the first flow rate adjustment operation of the user may be directly operated on the display screen, or may be operated through another input device, and is usually operated on the display screen.

And the adjustment can be carried out according to a preset step length. That is, in step S104, the controlling the first flow rate to increment or decrement specifically includes: and controlling the first flow rate to increase or decrease according to a preset step length.

Step S105: displaying the increased or decreased first flow rate on a display screen of the blood purification apparatus.

As shown in fig. 3, after determining the first flow rate of the blood circuit according to the physiological characteristic parameter of the patient, the display screen is controlled to display a treatment parameter interface, wherein the treatment parameter interface may include: when a user triggers the blood pump flow speed adjusting button (namely, the first flow speed adjusting operation of the user is realized through the blood pump flow speed adjusting button), a blood flow speed adjusting instruction is generated due to the triggering of the blood pump flow speed adjusting button, the first flow speed is controlled to be increased or decreased according to a preset step length according to the blood flow speed adjusting instruction, and the treatment parameter interface is controlled to display the increased or decreased first flow speed.

For example, the preset step size is 5 ml/min; if the current first flow rate is 50ml/min, when the detected first flow rate adjusting operation of the user is that the blood flow rate adjusting instruction of the user is received, the current first flow rate is controlled to be increased or decreased according to the blood flow rate adjusting instruction, and then the increased first flow rate is 55ml/min or the decreased first flow rate is 45 ml/min.

Since the first flow rate is increased or decreased according to the preset step length in the embodiment, the standardized setting of the first flow rate in the adjusting process is facilitated, and the adjusting rate of the first flow rate can be increased.

Wherein the blood flow rate adjustment instruction generated by the first flow rate adjustment operation of the user includes: a blood flow rate up-regulation instruction or a blood flow rate down-regulation instruction; the first flow rate can be controlled to be increased by a preset step length according to the blood flow rate increasing instruction, or the first flow rate can be controlled to be decreased by a preset step length according to the blood flow rate decreasing instruction.

As shown in fig. 3, after determining the first flow rate of the blood circuit according to the physiological characteristic parameter of the patient, the display screen is controlled to display a treatment parameter interface, wherein the treatment parameter interface may include: the blood pump flow rate control device comprises a blood pump flow rate adjusting button, an up-regulating button and a down-regulating button, wherein when a user triggers the up-regulating button, the blood pump flow rate adjusting button is controlled to be switched to an up-regulating function mode, when the user triggers the blood pump flow rate adjusting button under the up-regulating function mode, a blood flow rate up-regulating instruction of the user is received, according to the blood flow rate up-regulating instruction, the first flow rate is controlled to be gradually increased according to a preset step length, and the treatment parameter interface is controlled to display the gradually increased first flow rate. Similarly, when the user triggers the down-regulation button, the blood pump flow speed regulation button is controlled to be switched to a down-regulation function mode, and in the down-regulation function mode, when the user triggers the blood pump flow speed regulation button, the blood pump flow speed regulation button receives a blood flow speed down-regulation instruction of the user, the first flow speed is controlled to be decreased according to a preset step length according to the blood flow speed down-regulation instruction, and the therapy parameter interface is controlled to display a decreased first flow speed recommended value.

The embodiment can change the functional mode of blood pump velocity of flow adjustment button at any time according to the button of transferring upward and transferring downward, so can control first velocity of flow and increase or reduce, and the operation is very convenient.

In one embodiment, the second flow rate may also be automatically changed after the first flow rate is changed. That is, step S103, the determining the second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range may further include: and determining the adjusted second flow rate of the plasma bypass branch according to the increased or decreased first flow rate and the rate ratio range.

After the first flow rate is adjusted, the second flow rate can be automatically adjusted according to the adjusted first flow rate, and a user does not need to manually adjust the second flow rate. Therefore, after the user adjusts the first flow rate, the adjusted second flow rate can be determined according to the rate ratio range, the automatic adjustment function of the second flow rate can be completed, the ratio of the adjusted second flow rate to the adjusted first flow rate can be always kept in the rate proportion range, the separation efficiency of the plasma separator on the plasma is always optimal, and the problem that the DPMAS treatment efficiency is reduced when the user adjusts the first flow rate can be prevented.

After determining the adjusted second flow rate, the method may further include: the adjusted second flow rate is displayed. Wherein after determining the adjusted second flow rate of the plasma bypass, controlling a display screen to display a treatment parameter interface, wherein the treatment parameter interface comprises: the adjusted second flow rate is convenient for a user to check the change condition of the second flow rate in real time.

For example, as shown in fig. 3, if the first flow rate after the increment is: 55ml/min, rate ratio range: 1.25-1.28, the adjusted second flow rate is: the flow rate is 55/(1.25-1.28) ml/min to (42.96-44) ml/min, for example, the adjusted second flow rate is 43 ml/min.

In one embodiment, when the first flow rate is adjusted, it is required to determine whether the current first flow rate is within the flow rate adjustable range, and the first flow rate is adjusted when the current first flow rate is determined to be within the flow rate adjustable range, so that the safety problem caused by exceeding the flow rate alarm value can be avoided. That is, in step S104, the controlling the first flow rate to be increased or decreased according to the detected first flow rate adjustment operation of the user may further include: and when the current first flow rate is determined to be in the flow rate adjustable range of the blood circuit, controlling the first flow rate to be increased or decreased according to the detected first flow rate adjusting operation of the user.

The present embodiment may first determine whether the current first flow rate is within the adjustable range of the flow rate of the blood circuit. The "current first flow rate" may refer to a current flow rate of the blood circuit, and if the first flow rate is displayed on the display screen, the "current first flow rate" may refer to the first flow rate displayed on the display screen.

Only when the current first flow rate is in the flow rate adjustable range, the current first flow rate can be adjusted; conversely, if the current first flow rate is not within the flow rate adjustable range, the incremented or decremented first flow rate may exceed the maximum or minimum alarm value of the blood circuit.

And when the current first flow rate is judged to be in the flow rate adjustable range of the blood circuit, controlling the first flow rate to increase or decrease according to a preset step length according to a blood flow rate adjusting instruction generated by the detected first flow rate adjusting operation of the user. If the current first flow rate is judged not to be in the flow rate adjustable range of the blood circuit, the current first flow rate cannot be adjusted.

For example, the maximum alarm value of the blood circuit is 100ml/min, the minimum alarm value of the blood circuit is 20ml/min, and the preset step length is 5ml/min, then the preset adjustable range of the flow rate is: (25-95) ml/min; assuming that the current first flow rate is 96ml/min, if the 96ml/min is further incremented by 5ml/min, the incremented first flow rate is 101ml/min, which has exceeded the maximum alert value 100mln/min of the blood circuit.

Therefore, the embodiment of the application can avoid that the adjusted first flow rate exceeds the flow rate warning value of the blood circuit by setting the flow rate adjustable range, and can ensure the safety of the user in adjusting the first flow rate.

If the display screen displays a blood pump flow speed adjusting button capable of adjusting the first flow speed, in order to avoid possible misoperation of a user, the blood pump flow speed adjusting button can be controlled to be in an operable activated state or an inoperable inactivated state under the condition of determining whether the current first flow speed can be adjusted.

Referring to fig. 3, after determining the first flow rate of the blood circuit according to the physiological characteristic parameter of the patient in step S102, the method may further include: and controlling a display screen of the blood purification equipment to display a treatment parameter interface, wherein the treatment parameter interface comprises a first flow rate and blood pump flow rate adjusting button. At this time, whether the current first flow rate is in the flow rate adjustable range of the blood circuit or not can be judged, and if the current first flow rate is in the flow rate adjustable range of the blood circuit, the blood pump flow rate adjusting button is controlled to be in an operable activation state; if the current first flow rate is judged not to be in the flow rate adjustable range of the blood circuit, the blood pump flow rate adjusting button is controlled to be in an inoperable and non-activated state (such as a disabled state, a hidden state and the like). The blood pump flow speed adjusting button can receive a first flow speed adjusting operation of a user only when being in an activated state, so that under the condition that the blood pump flow speed adjusting button is in the activated state, when a blood flow speed adjusting instruction generated by the first flow speed adjusting operation of the user is received, the first flow speed is controlled to be increased or decreased according to a preset step length. The blood pump flow rate adjusting button cannot receive a first flow rate adjusting operation of a user when being in an inactive state, for example, the blood pump flow rate adjusting button in the inactive state cannot be triggered, the blood pump flow rate adjusting button hidden cannot be triggered, and at this time, the first flow rate cannot be adjusted. Therefore, possible misoperation of the user can be avoided, and the safety of treatment is further ensured.

In one embodiment, the determining the second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio range in step S103 may include: sub-step S1031 and sub-step S1032.

Substep S1031: a rate scaling value is determined within the rate scaling range.

Sub-step S1032: and determining a second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio value.

Wherein, determining a rate proportion value in the rate proportion range may be selecting a rate proportion value in the rate proportion range according to a proportion selection instruction of a user.

For example, the rate scale range is: 1.25-1.28, the selected rate ratio value of 1.25-1.28 is 1.26, and if the first flow rate is 50ml/min, the second flow rate is calculated by the formula: (50/1.26) ml/min 39.68 ml/min. In this manner, the second flow rate can be automatically determined.

In an embodiment, the user may also adjust the second flow rate. Namely, the method further comprises: and step S106. Step S106: re-determining a rate scaling value in said rate scaling range in response to a detected second flow rate adjustment operation by the user; in this case, the sub-step S1032 of determining the second flow rate of the plasma bypass branch according to the first flow rate and the rate ratio value may further include: and determining the adjusted second flow rate of the plasma bypass branch according to the first flow rate and the re-determined rate ratio value.

When the second flow rate adjusting operation of the user is detected, it indicates that the user needs to adjust the second flow rate, and the user only needs to reset a rate proportion value in the rate proportion range to re-determine the second flow rate, thereby completing the adjusting function of the second flow rate.

The second flow rate is adjusted by adjusting the rate proportion value, the ratio between the first flow rate and the adjusted second flow rate can be ensured to be in the rate proportion range all the time, and the separation efficiency of the plasma separator can be improved.

For example, referring to fig. 4, in step S103, after determining the second flow rate of the plasma bypass according to the first flow rate and the rate ratio range, the display screen may be controlled to display a treatment parameter interface, wherein the treatment parameter interface includes a second flow rate and a plasma pump flow rate adjustment button.

When it is detected that the user triggers the plasma separation pump flow rate adjustment button (i.e., a second flow rate adjustment operation of the user), a plasma flow rate adjustment instruction is generated, and the display screen is controlled to pop up a parameter setting window (as shown in fig. 4) according to the plasma flow rate adjustment instruction, where the parameter setting window includes a parameter input box and a determination button, and the user inputs a reset rate ratio value in the parameter input box, such as the rate ratio value is reset: 1.19, and after the user triggers the 'confirm' button, the control display screen redisplays the treatment parameter interface, calculates the second flow rate after adjustment to be 50/1.19-40.02 ml/min according to the current first flow rate of 50ml/min and the reset rate proportion value of 1.19, and displays the second flow rate after adjustment to be 40.02ml/min on the treatment parameter interface, so as to complete the adjustment function of the second flow rate.

In the above, when the user inputs the reset rate scale value in the parameter input box, the user can only input the value in the rate scale range, but cannot input the value beyond the rate scale range. For example, when the user inputs a value out of the rate scale range, and the user clicks the "confirm" button, the display will pop up a message prompt box of "parameter input error, please re-input" until the user inputs a value in the rate scale range in the parameter input box.

In one embodiment, the return of blood is performed at the end of the treatment session. Namely, the method further comprises: step S107, step S108, step S109, step S110, and step S111.

Step S107: recording the blood flow time of the blood circuit.

Step S108: and when the blood flowing time reaches a first preset time, controlling the plasma in the plasma bypass branch to stop flowing.

Step S109: and (3) inputting physiological saline to the blood circuit, controlling the physiological saline in the blood circuit to flow at a third flow rate so as to carry out blood return on the blood circuit, and recording the blood return time of the blood circuit. Wherein the third flow rate is less than the first flow rate.

Step S110: and when the blood return time of the blood circuit reaches a second preset time, controlling the physiological saline in the blood circuit to stop flowing.

Step S111: and (3) conveying normal saline to the plasma bypass flow branch, and controlling the normal saline in the plasma bypass flow branch to flow at a fourth flow rate so as to carry out blood return on the plasma bypass flow branch. Wherein the fourth flow rate is less than the second flow rate.

When the blood circuit is controlled to perform blood flow at a first flow rate, recording of the blood flow time of the blood circuit is started.

The first preset time may refer to a time when the blood purification treatment is ended. When the blood flowing time of the blood circuit reaches the first preset time, the blood purification treatment is ended, and then the blood return of the blood circuit is started. The blood return may be: the residual blood in the blood circuit and the residual plasma in the plasma bypass branch are all returned to the veins of the human body. The normal method of blood return is to introduce physiological saline into the pipeline, and the residual blood or residual plasma in the pipeline is flushed to the veins of the human body through the physiological saline.

The blood return of the embodiment of the application is divided into two stages. In the first stage, the blood return is carried out on the blood loop by adopting normal saline according to a third flow rate, and at the moment, the plasma in the plasma bypass branch stops flowing so as to ensure the sufficient blood return of the blood loop; and in the second stage, the blood return is firstly carried out on the plasma bypass branch by adopting the physiological saline according to the fourth flow rate, and the liquid in the blood loop is controlled to stop flowing at the moment so as to ensure the sufficient blood return of the plasma bypass branch.

Wherein the third flow rate is less than the first flow rate and the fourth flow rate is less than the second flow rate. Clinical experiments show that the blood return rate in the pipeline is kept slow, the blood return safety is higher, and blood or plasma remaining in the pipeline can be avoided as much as possible. Therefore, the present embodiment sets the blood return rate (i.e. the third flow rate) of the blood circuit and the blood return rate (i.e. the fourth flow rate) of the plasma bypass as small as possible to achieve the best blood return effect.

The third flow rate and the fourth flow rate may both be predetermined. If the third flow rate and the fourth flow rate are not set, before controlling the saline in the blood circuit to flow at the third flow rate in step S109, the method may further include: setting a third flow rate of the blood circuit; before controlling the saline in the plasma bypass branch to flow at the fourth flow rate in step S111, the method may further include: setting a fourth flow rate of the plasma bypass branch.

In an embodiment, the blood purification apparatus further comprises a heparin output branch (as shown in fig. 1) for delivering heparin to the blood circuit, wherein the heparin can achieve the anticoagulation effect. Since the blood in the blood circuit fails to coagulate if the blood is not anticoagulated in the extracorporeal circuit when the blood is drawn into the extracorporeal circuit, anticoagulation is required during the treatment. Wherein after step S103, the method may further comprise: step S112.

Step S112: and when the blood circuit is controlled to flow according to the first flow rate, determining a fifth flow rate of the heparin output branch according to the physiological characteristic parameters of the patient.

And obtaining the constitution of the patient according to the physiological characteristic parameters of the patient, and then determining the heparin output flow rate of the heparin output branch circuit, namely a fifth flow rate according to the constitution of the patient.

It should be noted that there is a corresponding relationship between the flow rate of heparin output and the physical condition of the patient. For example, for some patients with a tendency to bleed (e.g., during post-operative recovery), the heparin output rate needs to be slower and the amount of heparin used needs to be smaller to minimize the side effects of heparin; on the contrary, for some patients, the constitution is good, the blood volume in vivo is large, the heparin output rate needs to be as fast as possible, and the heparin usage amount also needs to be large, so that the output heparin can realize the best anticoagulation effect in the blood loop.

Through the mode, medical personnel can set the heparin output rate according to the physiological characteristic parameters of the patient, and the treatment safety of the patient can be guaranteed.

After step S112, the method may further include: the control display screen displays a treatment parameter interface, as shown in fig. 3, wherein the treatment parameter interface may include a fifth flow rate to facilitate direct review of the fifth flow rate by the healthcare worker.

In an embodiment, the user may also adjust the fifth flow rate. That is, after step S112, the method may further include: and when detecting the heparin flow rate adjusting operation of the user, controlling the fifth flow rate to increase or decrease according to a preset step length, and displaying the increased or decreased fifth flow rate on a display screen.

Referring to fig. 3, the treatment parameter interface may further include: a heparin flow rate adjustment button that the user triggers to change the fifth flow rate. The specific implementation of adjusting the fifth flow rate is similar to the first flow rate and the second flow rate, and specific reference may be made to the specific implementation of adjusting the first flow rate and the second flow rate, which is not described herein in detail.

Referring to fig. 5, fig. 5 is a schematic structural diagram of an embodiment of the blood purification apparatus of the present application, the blood purification apparatus includes a blood circuit 14, a plasma separator 3 and a plasma bypass 13, the blood circuit 14, the plasma separator 3 and the plasma bypass 13 are disposed on a host 100 of the blood purification apparatus, the blood purification apparatus further includes a memory 200 and a processor 300, the memory 200 is used for storing a computer program; the processor 300 is configured to execute the computer program and realize the control method of the blood purification apparatus as described above when executing the computer program. For a detailed description of the related contents, please refer to the related contents of the control method of the blood purification apparatus, which will not be described redundantly.

The host 100, the memory 200, and the processor 300 are connected by a bus.

The processor 300 may be a micro-control unit, a central processing unit, a digital signal processor, or the like.

The memory 200 may be a Flash chip, a read-only memory, a magnetic disk, an optical disk, a usb disk, or a removable hard disk, among others.

The present application also provides a computer-readable storage medium storing a computer program which, when executed by a processor, causes the processor to implement the method of controlling a blood purification apparatus as described in any one of the above. For a detailed description of the related contents, please refer to the related contents of the control method of the blood purification apparatus, which will not be described redundantly.

The computer readable storage medium may be an internal storage unit of the blood purification apparatus, such as a hard disk or a memory. The computer readable storage medium may also be an external storage device such as a hard drive equipped with a plug-in, smart memory card, secure digital card, flash memory card, or the like.

It should be noted that the data referred to in the tables, graphs and formulas in the present specification are only for illustration, and do not mean that the blood purification apparatus is the pressure values in the actual application process.

It is to be understood that the terminology used in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

It should also be understood that the term "and/or" as used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.

The above description is only for the specific embodiment of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive various equivalent modifications or substitutions within the technical scope of the present application, and these modifications or substitutions should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.