阅读说明：本技术 一种用于骨性疾病疼痛的药物组方 (Medicine formula for treating bone disease pain ) 是由 高炳森 于 2021-09-24 设计创作，主要内容包括：本发明公开一种用于骨性疾病疼痛的药物组方,其由酒炒黄柏、烫骨碎补、盐炒续断、铁线威灵仙、酒炙虫、酒洗乌梢蛇、姜汁浸川乌、姜汁浸草乌、烘焙露蜂房、臭冷杉提取物、油松节提取物、松黄提取物组成。本发明的组方各原料药有效的发挥药效,共同作用,具有祛风止痛、通经活络、杀菌消炎等功效,并且具有修复再生之功能,不仅对各类骨性疾病疼痛,特别是骨关节炎、椎间盘突出,颈、肩、腰腿等等关节退行性病变引起的疼痛进行有效的缓解,并且还对各类骨性疾病起到很好的辅助治疗的效果,安全有效,未有任何副作用。(The invention discloses a medicine composition for treating bone disease pain, which is prepared from phellodendron bark stir-fried with wine, scalded drynaria rhizome, dipsacus root stir-fried with salt, clematis root, and wine)

1. The medicine formula for treating the bone disease pain is characterized by comprising the following raw material medicines:

cortex Phellodendri (parched with wine), rhizoma Drynariae (scalded), radix Dipsaci (parched with salt), radix Clematidis (processed with iron wire), and radix Clematidis (processed with wine)Worm, wine-washed zaocys dhumnade, ginger juice-soaked radix aconiti kusnezoffii, baked nidus vespae, abies robusta extract, Chinese pine knot extract and pine pollen extract.

2. The pharmaceutical formulation for bone disease pain according to claim 1, wherein the weight amounts of the raw materials are:

10-30 parts of phellodendron amurense fried with wine, 10-30 parts of scalded rhizoma drynariae, 10-30 parts of salt-fried teasel root, 10-30 parts of clematis chinensis with iron wire and wine-fried5-15 parts of worm, 5-15 parts of wine-washed zaocys dhumnade, 5-10 parts of ginger juice-soaked monkshood, 5-10 parts of ginger juice-soaked kusnezoff monkshood root, 5-15 parts of baked nidus vespae, 0.5-1.0 part of abies robusta extract, 0.5-1.0 part of Chinese pine node extract and 0.5-1.0 part of Chinese pine yellow extract.

3. The pharmaceutical composition for treating bone disease pain according to claim 1 or 2, wherein the salt-fried teasel root is prepared from green salt, and the wine-fried phellodendron amurense are prepared from the green saltThe worm and wine washing zaocys dhumnade are made of 60-65 degree white spirit.

4. The pharmaceutical formulation for bone disease pain according to claim 1 or 2, wherein it is used as a topical liniment.

5. The pharmaceutical formulation for pain of osteoarticular diseases according to claim 4,

the preparation method of the external smearing liquid comprises the following steps:

soaking processed materials except for Abies sinensis extract, lignum Pini nodi extract and Colophonium extract in Chinese liquor for half a year to one year, filtering to obtain filtrate, adding Abies sinensis extract, lignum Pini nodi extract and Colophonium extract into the filtrate, and mixing.

Technical Field

The invention relates to the technical field of medicines, in particular to a medicine formula for treating bone disease pain.

Background

With the accelerated aging process, the middle-aged and the elderly have prominent bone diseases, particularly osteoarthritis, herniated disk, joint degenerative changes such as neck, shoulders, waist and legs and the like, which are usually accompanied by serious pain, and the life quality of patients can be seriously influenced.

Disclosure of Invention

Therefore, based on the background, the invention aims to provide a pharmaceutical formulation for treating bone disease pain, which mainly has the functions of relaxing tendons and activating collaterals, clearing damp and relieving pain, repairing and regenerating and the like, can remarkably relieve various bone disease pain, and can play a good auxiliary treatment effect on various bone diseases.

The technical scheme provided by the invention is as follows:

a medicine formula for treating bone disease pain is composed of the following raw materials:

cortex Phellodendri (parched with wine), rhizoma Drynariae (scalded), radix Dipsaci (parched with salt), radix Clematidis (processed with iron wire), and radix Clematidis (processed with wine)Worm, wine-washed zaocys dhumnade, ginger juice-soaked radix aconiti kusnezoffii, baked nidus vespae, abies robusta extract, Chinese pine knot extract and pine pollen extract.

Further, the weight and the dosage of the raw materials are respectively as follows:

10-30 parts of phellodendron amurense fried with wine, 10-30 parts of scalded rhizoma drynariae, 10-30 parts of salt-fried teasel root, 10-30 parts of clematis chinensis with iron wire and wine-fried5-15 parts of worm, 5-15 parts of wine-washed zaocys dhumnade, 5-10 parts of ginger juice-soaked monkshood, 5-10 parts of ginger juice-soaked kusnezoff monkshood root, 5-15 parts of baked nidus vespae, 0.5-1.0 part of abies robusta extract, 0.5-1.0 part of Chinese pine node extract and 0.5-1.0 part of Chinese pine yellow extract.

Further, the salt-fried teasel root is prepared from green salt, and the wine-fried golden cypress and the wine-fried stir-fried teasel root are prepared from wineThe worm and wine washing zaocys dhumnade are carried out by adopting white spirit with the temperature of 60 ℃.

Further, it is used in the form of a liquid for external application.

Further, the preparation method of the external smearing liquid comprises the following steps:

soaking processed materials except for Abies sinensis extract, lignum Pini nodi extract and Colophonium extract in Chinese liquor for half a year to one year, filtering to obtain filtrate, adding Abies sinensis extract, lignum Pini nodi extract and Colophonium extract into the filtrate, and mixing.

The abies spruce extract in the formula contains a plurality of specific organic components, the components are higher, such as borneol acetate, camphene, limonene, borneol and alpha-bisabolol, and the extract also contains flavone and glycoside compounds thereof, has the functions of analgesia, antipyresis, anti-inflammation and the like, and has good analgesic effect on rheumatism, arthralgia, spasm and spasm of muscles and traumatic injury; the lignum Pini nodi extract mainly contains cellulose, lignin, a small amount of volatile oil (oleum Terebinthinae) and resin; the volatile oil contains alpha-pinene and beta-pinene, and small amount of l-camphene, and has effects of dispelling pathogenic wind, eliminating dampness, relieving rigidity of muscles, and dredging collaterals; the extract of Colophonium contains multiple nutrients including 22 amino acids, 14 vitamins, 30 trace elements, and a large amount of active protease, core, flavonoids and other active substances, and has effects of dispelling pathogenic wind, invigorating qi, eliminating dampness, and stopping bleeding; the cortex phellodendri has the effects of clearing heat, eliminating dampness, purging fire, removing steam, detoxifying, treating sore and the like; rhizoma Drynariae has effects of promoting blood circulation and healing wound; radix Dipsaci has effects of nourishing liver and kidney, strengthening tendons and bones, and treating fracture; the clematis chinensis, also known as clematis chinensis, has the effects of expelling wind-damp, dredging the channels and collaterals and the like;the insect has effects of removing blood stasis, removing food retention, dredging collaterals, and removing injury; zaocys has effects of dispelling pathogenic wind, dredging collaterals, relieving spasm, etc.; radix Aconiti has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain; the radix Aconiti Kusnezoffii has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain; the nidus Vespae has effects of dispelling pathogenic wind, removing toxic substances, and killing parasite.

The formula of the invention mainly comprises two parts, wherein one part is the abies spruce extract, the lignum pini extract and the pine pollen extract which are extracted from natural plants, and the other part is the traditional Chinese medicines which are matched with the abies spruce extract, the lignum pini extract and the pine pollen extract and are prepared by different processing methods, so that the raw materials can more effectively exert the drug effect and have the combined action, have the effects of dispelling wind, relieving pain, clearing and activating the channels and collaterals, sterilizing and diminishing inflammation and the like, have the functions of repairing and regenerating, not only effectively relieve pain caused by various bone diseases, particularly osteoarthritis, herniated disk, neck, shoulder, waist and leg and other joint degenerative diseases, but also have good auxiliary treatment effect on various bone diseases, and are safe and effective without any side effect.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1: a Chinese medicinal composition for relieving pain caused by bone diseases is prepared from cortex Phellodendri (parched with wine) 10 parts, rhizoma Drynariae (scalded) 15 parts, radix Dipsaci (parched with salt) 15 parts, radix Clematidis (processed with wine) 15 parts, and radix Clematidis (parched with wine)10 parts of worm, 10 parts of wine-washed zaocys dhumnade, 5 parts of ginger juice-soaked monkshood, 5 parts of ginger juice-soaked kusnezoff monkshood root, 10 parts of baked nidus vespae, 0.5 part of abies obovata extract, 0.5 part of lignum pini nodi extract and 0.5 part of phellodendron extract.

Example 2: a Chinese medicinal composition for relieving pain caused by bone diseases is prepared from cortex Phellodendri (parched with wine) 20 parts, rhizoma Drynariae (scalded) 20 parts, radix Dipsaci (parched with salt) 20 parts, radix Clematidis (processed with wine) 20 parts, and radix Clematidis (parched with wine)10 parts of worm, 10 parts of wine-washed zaocys dhumnade, 5 parts of ginger juice-soaked monkshood, 5 parts of ginger juice-soaked kusnezoff monkshood root, 10 parts of baked nidus vespae, 1.0 part of abies obovata extract, 1.0 part of lignum pini nodi extract and 1.0 part of phellodendron extract.

Example 3: a Chinese medicinal composition for relieving pain caused by bone diseases is prepared from cortex Phellodendri (parched with wine) 25 parts, rhizoma Drynariae (scalded) 25 parts, radix Dipsaci (parched with salt) 25 parts, and ferrumClematis root 25 parts, stir-baked with wine15 parts of worm, 15 parts of wine-washed zaocys dhumnade, 5 parts of ginger juice-soaked monkshood, 5 parts of ginger juice-soaked kusnezoff monkshood root, 15 parts of baked nidus vespae, 1.0 part of abies obovata extract, 1.0 part of lignum pini nodi extract and 1.0 part of phellodendron extract.

Example 4: a Chinese medicinal composition for relieving pain caused by bone diseases is prepared from cortex Phellodendri (parched with wine) 30 parts, rhizoma Drynariae (scalded) 30 parts, radix Dipsaci (parched with salt) 30 parts, radix Clematidis (processed with wine) 25 parts, and radix Clematidis (parched with wine)10 parts of worm, 10 parts of wine-washed zaocys dhumnade, 5 parts of ginger juice-soaked monkshood, 5 parts of ginger juice-soaked kusnezoff monkshood root, 10 parts of baked nidus vespae, 1.0 part of abies obovata extract, 1.0 part of lignum pini nodi extract and 1.0 part of phellodendron extract.

The medicines of example 1 and example 4 were prepared into external application coating solutions, which were prepared by the following methods:

soaking processed raw materials except for Abies sinensis extract, lignum Pini nodi extract and Colophonium extract in 5000 parts of Chinese liquor for half a year to one year, filtering to obtain filtrate, adding Abies sinensis extract, lignum Pini nodi extract and Colophonium extract into the filtrate, mixing, and bottling.

The abies spruce extract, the lignum pini nodi extract and the pine pollen extract of examples 1 to 4 can be prepared by respectively physically squeezing and extracting fresh abies spruce, lignum pini nodi and pine pollen to obtain partial stock solutions, performing high-temperature treatment and filtering; or distilling ground Abies sinensis, lignum Pini nodi, and Colophonium respectively, and condensing to obtain the final product.

The invention uses the notes:

1) pregnant women and infants within 20 days should be used with caution;

2) few patients have local skin allergic reaction, do not need to stop taking the medicine, can be continuously used, and can not bring any harm and sequelae to the skin appearance and body.

Example 5: clinical curative effect of lumbar intervertebral protrusion of old people

62 patients with senile lumbar disc herniation are selected, and all the patients meet the clinical diagnosis standard of lumbar disc herniation in clinic; the age is more than or equal to 60 years old. Excluding the patients who had received the related treatment intervention before, excluding the serious organ dysfunction and disorder, dividing 62 patients into two groups according to the method of drawing, namely a control group and an experimental group, wherein the control group comprises 31 patients, the age is 65-90 years old, the mean age (65..89 +/-1.2) years old, 21 male patients, 11 female patients, the mean weight (56.9 +/-8.9) kg, and the segment of responsibility: L4-L5: 5 cases, L5 to S1: example 6, L4 to L5: 4 cases; experimental group 31, ages 65-90, mean age (66.10 ± 1.4) years, 19 of male patients, 12 of female patients, mean body weight (57.2 ± 8.5) kg segment of responsibility: L4-L5: example 6, L5 to S1: 5 cases, L4 to L5: example 5. General data from both groups were observed and compared, with no statistical difference (P > 0.05).

The control group adopts traction treatment, adopts YX-II type traction chair of Jiangsu Xinxin medical equipment Limited company, traction weight ranges from 5kg to 15kg, 30 min/time and 1 time/d, and the experimental group adds the external application liquid of the embodiment 2 on the basis of the control group, coats the external application liquid on the patient and the pain part of the patient, coats the external application liquid once every 4h and continues the treatment for 1 month.

Observation indexes are as follows: assessment of pain level Visual Analogue (VAS) scores were used; the evaluation of the activity function of the cervical vertebra adopts Oswestry dysfunction score (ODI), and the higher the score is, the worse the activity function is.

Evaluation criteria:

the effect is shown: the ODI score reduction rate is more than 70%, and the cervical vertebra movement function is normal;

the method has the following advantages: the ODI score reduction rate is 40% -70%, and the cervical vertebra activity function is improved;

and (4) invalidation: the above standard cannot be achieved.

The results show that after the control group is treated, 8 cases are effective, 15 cases are effective, 8 cases are ineffective, and the effective rate is 74.42%; the experimental group has 12 effective cases, 17 effective cases and 2 ineffective cases, and the effective rate is 93.02%.

The VAS score differences of the two groups at 1 week and 2 weeks after treatment have statistical significance (both are less than 0.05); comparison of VAS before and after treatment is shown in Table 1.

Table 1: comparison of VAS scores before and after treatment in two groups

As can be seen from the treatment condition of the lumbar disc herniation for the elderly, the invention can play a good auxiliary treatment effect, can effectively improve the treatment effective rate, and can more effectively relieve pain.

Example 7: clinical curative effect of knee osteoarthritis of old people

Selecting 86 patients with confirmed diagnosis of the senile lumbar disc herniation, wherein all the patients meet the related diagnosis standard of knee osteoarthritis diagnosis standard, have unilateral pathological changes, and exclude other knee joint diseases such as gout, rheumatoid arthritis, secondary arthritis and the like, systemic infection, endocrine diseases, mental diseases, important organic dysfunction of liver and kidney and the like, incomplete pathological data, poor compliance and the like, randomly dividing the patients into two groups according to a drawing method, wherein the two groups are respectively a control group and an experimental group, and the control group comprises 20 males and 23 females; age 42-70 years, mean age (56.37 + -5.43 years); the course of disease is 2-21 years, and the average course of disease (11.36 +/-3.22) years. Experimental groups 21 males and 22 females; age 43-70 years, mean age (56.84 + -5.26 years); the course of disease is 2-20 years, and the average course of disease (11.02 +/-3.11) years. General data from both groups were observed and compared, with no statistical difference (P > 0.05).

The patients in the control group were treated with glucosamine sulfate capsule (Hubei Epson engineering Co., Ltd., national Standard: H20090316, specification: 0.25g), orally administered at a dose of 0.5 g/time for 3 times/day for 6 weeks as 1 treatment course; the experimental group was supplemented with the topical liniment of example 2 on the basis of the control group, and the topical liniment was applied to the affected part and the pain area once every 4h for 1 month.

Observation indexes are as follows: the pain level before and after treatment and the recovery of the knee joint function were compared, and the pain level was evaluated by Visual Analogue (VAS) scoring.

Evaluation criteria:

the effect is shown: after treatment, symptoms such as swelling and pain disappear, the knee joint function returns to normal or the foundation returns to normal, and the patella extrusion test result is negative;

the method has the following advantages: after treatment, symptoms such as swelling, pain and the like are obviously improved, the knee joint function is basically recovered, and the patella extrusion test is obviously relieved;

and (4) invalidation: no obvious change in symptoms and knee joint function after treatment.

The results show that the control group has 16 effective cases, 22 effective cases and 5 ineffective cases after treatment, and the effective rate is 90 percent; the experimental group has 21 effective cases, 19 effective cases and 3 ineffective cases, and the effective rate is 95%.

The VAS score differences were statistically significant (both < 0.05) at 1 week post-treatment in both groups, and the VAS comparisons before and after treatment are shown in Table 2.

Table 2: comparison of VAS scores before and after treatment in two groups

As can be seen from the treatment situation of knee osteoarthritis in this embodiment, the present invention can achieve a good adjuvant treatment effect, can effectively improve the treatment effective rate, and can more effectively relieve pain.

Example 8: typical case

Case 1: leaf certain, male, 65 years old, CT examination: the pain at the lumbar vertebra L3/4 and L4/5 intervertebral disc herniation and the left side nerve root, the left knee joint and the ankle is pressed, the lumbar vertebra herniation is diagnosed to be lasting for 3 years, the pain is difficult to endure frequently, the normal life is seriously influenced, in 2019, the external application liquid of the embodiment 2 is matched with massage and bone penetration therapy for treatment, the pain feeling is obviously relieved on the second day after the external application liquid of the embodiment 2 is adopted, and after 1 and a half of continuous treatment, the symptoms completely disappear, no pain is caused, and the normal life can be realized.

Case 2: the cervical vertebra C5/6 protrusion of Tian Yi, a female aged 62 is checked, the movement of the left shoulder is limited and the pain is hard to endure, the cervical disc protrusion is confirmed, the external smearing of the embodiment 2 of the invention is adopted in 2019 to be matched with cervical traction for treatment, the pain is obviously relieved the next day after the external smearing liquid of the embodiment 2 is smeared on the pain position, along with the treatment, the pain is gradually reduced, the symptoms disappear after the treatment is continued for 15 days, the pain is not felt, and the left shoulder can normally move.

Case 3: wangzhi, male, age 76, sprain of left ankle due to carelessness, examination, X-ray calcaneal dehiscence, pulling of lateral musculature, local red swelling treatment, swelling and pain disappeared after one month but not walking, calcaneal force exertion, pain was hard to endure, recovery was assisted by the application of the liquid of example 3, twice a day, pain disappeared after three weeks, and walking was as usual.

Case 4: if a woman plum is 56 years old, the activity of the right shoulder is limited, the patient is accompanied by burning pain at the scapula, the sleep is influenced for two years, the cervical vertebra C4/5/6 hyperosteogeny is accompanied by spinal stenosis through CT examination, and the patient is treated by multi-party treatment, namely the external smearing liquid of the embodiment 4 is not used for treating the cervical vertebra C4/5/6 hyperosteogeny and the spinal stenosis in 12 months in 2020, the pain is obviously relieved after two days, the burning sensation at the scapula disappears, and after three weeks of continuous treatment, the symptoms disappear and the patient can move freely.

Case 5: wangzhi, male, 32 years old, love to play ball in weekdays, is diagnosed as tennis elbow because of the pain of the two upper limbs which are difficult to bend and stretch. The pain is exacerbated by touch. Intermittent to last for half a year. The recovery was then assisted with the spread of example 1 and a topical massage was applied twice daily, three days later the pain was relieved and two weeks later the pain disappeared as usual.

The present invention and the embodiments thereof have been described above, but the description is not limited thereto, and the embodiment shown is only one of the embodiments of the present invention, and the actual structure is not limited thereto. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.