阅读说明：本技术 一种肝素钠生产用干燥粉碎装置 (Heparin sodium production is with dry reducing mechanism ) 是由 王光永 于文明 徐亚朋 高赔赔 于 2021-09-23 设计创作，主要内容包括：本发明公开了一种肝素钠生产用干燥粉碎装置,涉及肝素钠生产加工技术领域。包括浓缩箱、干燥箱、粉碎箱和底座,干燥箱上端两侧开设有蒸汽出口,干燥箱内部下端中央转动连接中空的离心柱,离心柱上端设置有离心盘,离心盘上方连接离心桶,离心盘上表面设置多个分散槽,离心桶上端与干燥箱顶部滑动连接,第一连通口与离心桶上端中央相连通,干燥箱内壁上设置一层电热层。本发明克服了现有技术的不足,设计合理,使用方便,能够有效对肝素钠溶液进行干燥粉碎,且干燥效率高,生产加工连续性好,所得肝素钠粉末产品稳定性高,便于大规模生产使用。(The invention discloses a drying and crushing device for heparin sodium production, and relates to the technical field of heparin sodium production and processing. Including concentrated case, drying cabinet, crushing case and base, steam outlet has been seted up to drying cabinet upper end both sides, and the inside lower extreme central authorities of drying cabinet rotate and connect hollow centrifugal column, and centrifugal column upper end is provided with the centrifugal disk, and centrifugal bucket is connected to the centrifugal disk top, and the centrifugal disk upper surface sets up a plurality of dispersion tanks, centrifugal bucket upper end and drying cabinet top sliding connection, and first opening is linked together with centrifugal bucket upper end central authorities, sets up one deck electric heat layer on the drying cabinet inner wall. The invention overcomes the defects of the prior art, has reasonable design and convenient use, can effectively dry and crush the heparin sodium solution, has high drying efficiency and good production and processing continuity, and the obtained heparin sodium powder product has high stability and is convenient for large-scale production and use.)

1. The utility model provides a heparin sodium production is with dry reducing mechanism, is including concentrator box (2), drying cabinet (1) and crushing case (3) that communicate in proper order to and drying cabinet (1) bottom is provided with base (4), its characterized in that: the centrifugal drying device is characterized in that a first communicating hole (11) is formed in the center of the bottom of the concentration box (2) and communicated with the drying box (1), steam outlets (27) are formed in two sides of the upper end of the drying box (1), a second communicating hole (31) is formed in one side of the bottom of the drying box (1) and communicated with one side of the upper end of the crushing box (3), a hollow centrifugal column (16) is connected to the center of the lower end of the interior of the drying box (1) in a rotating mode, a centrifugal motor (6) is arranged inside the base (4), an output shaft of the centrifugal motor (6) extends into the interior of the drying box (1), an output shaft of the centrifugal motor (6) is connected with the centrifugal column (16) through a rotating belt (17), a centrifugal disc (15) is arranged at the upper end of the centrifugal column (16), a centrifugal barrel (14) with a hollow-out side wall is connected to the center above the centrifugal disc (15), and a plurality of dispersing grooves (40) are formed in the upper surface of the centrifugal disc (15) from the center to the periphery, the upper end of the centrifugal barrel (14) is slidably connected with the top of the drying box (1), the first communication port (11) is communicated with the center of the upper end of the centrifugal barrel (14), a first vent pipe (18) is arranged inside the centrifugal barrel (14), a ring of annular vent pipe (21) is arranged in the middle section of the outside of the centrifugal barrel (14), the lower ends of the two sides of the annular vent pipe (21) are symmetrically communicated with second vent pipes (20), the lower end of the first vent pipe (18) penetrates through the centrifugal disc (15) and is rotatably connected with the centrifugal disc (15), the bottom ends of the first vent pipe (18) and the second vent pipe (20) penetrate through the drying box (1) and extend to the inside of the base (4) to be communicated with the hot air blower (5), a plurality of first air blowing ports (19) are arranged around the first vent pipe (18), and a plurality of second air blowing ports (22) are arranged on one side of the annular vent pipe (21) close to the centrifugal barrel (14), the inner wall of the drying box (1) is provided with an electric heating layer (23).

2. The drying and crushing device for producing heparin sodium according to claim 1, wherein a ring of annular scraping plates (24) are connected to the inner wall of the drying box (1) in a sliding manner, air cylinders (25) are symmetrically arranged on two sides of the top end of the drying box (1), and the air cylinders (25) are connected with the upper ends of the annular scraping plates (24) through telescopic rods (26).

3. The drying and crushing device for producing heparin sodium according to claim 1, wherein a suction fan (28) is arranged inside the steam outlet (27), and a filter screen layer (29) is arranged at the lower end of the suction fan (28).

4. The drying and crushing device for heparin sodium production according to claim 1, wherein the first air blowing port (19) is arranged obliquely downward, the second air blowing port (22) is arranged obliquely downward to one side, and the top end of the first air pipe (18) is provided with an inclined plate (30) which is inclined downward from the center to the periphery.

5. The drying and crushing device for producing heparin sodium according to claim 1, wherein the periphery of the centrifugal disc (15) is bent in an upward inclined manner.

6. The drying and crushing device for producing heparin sodium according to claim 1, wherein a first feeding hole (7) is formed in one side of the top end of the concentration box (2), a stirring motor (8) is arranged in the center above the top end of the concentration box (2), the stirring motor (8) is connected with a first rotating shaft (9) arranged inside the concentration box (2), electric heating plates (10) are arranged on the periphery of the first rotating shaft (9), and a liquid separating mechanism is arranged at the first communication hole (11) and communicated with the drying box (1).

7. The drying and crushing device for producing heparin sodium according to claim 6, wherein the liquid separating mechanism comprises a second rotating shaft (12) rotatably connected with the inside of the first communicating port (11) and a material separating blade (13) arranged around the second rotating shaft (12), the material separating blade (13) is slidably connected with the inner wall of the first communicating port (11), and the second rotating shaft (12) is connected with a material separating motor (39) outside the concentrating box (2).

8. The drying and crushing device for producing heparin sodium according to claim 1, wherein a second feeding hole (32) is formed in the upper end of one side of the crushing box (3), a circle of grinding layer (33) is arranged on the side wall of the center inside the crushing box (3), three grinding rollers (34) which are arranged in an inverted triangle shape are arranged in the center of the grinding layer (33), and a second discharging hole (38) is formed in one side of the bottom of the crushing box (3).

9. The drying and crushing device for producing heparin sodium according to claim 8, wherein a screen mesh layer (36) is arranged below the grinding roller (34), the screen mesh layer (36) is inclined, a first discharge hole (37) is formed in one side wall of the inclined lower end of the screen mesh layer (36), and a vibrator (41) is arranged at the bottom of the screen mesh layer (36).

10. The drying and crushing device for producing heparin sodium according to the claim 9, wherein a heating layer (35) is arranged inside the grinding roller (34).

Technical Field

The invention relates to the technical field of heparin sodium production and processing, in particular to a drying and crushing device for heparin sodium production.

Background

Heparin sodium is a sodium salt of glycosaminoglycan sulfate extracted from animal internal organs, belongs to mucopolysaccharide substances, and generates an anticoagulant function through combination with antithrombin. Clinical research shows that the heparin sodium has various other biological activities and clinical purposes besides the anticoagulation effect, can treat acute venous thrombosis and acute coronary syndrome, angina pectoris, myocardial infarction, thrombus resistance and blood fat reduction, can inhibit the formation of in-vivo in-vitro artery and vein thrombosis without influencing platelet aggregation and the combination of fibrinogen and platelets, and can be used for reducing the recurrence of cancer-related venous thrombosis. In addition, heparin sodium also has the biological functions of anti-inflammation, anti-allergy and the like.

The preparation of general heparin sodium is mostly extracted from pig small intestine mucous membrane, multiple solvent usually need be adopted in the extraction process, obtain the extract, finally carry out crushing treatment to the dry result after drying to the extract again, collect heparin sodium finished product powder, because heparin sodium heat resistance is better, the most direct high temperature drying that adopts of current drying method, but because liquid content is higher in the extract, direct high temperature drying efficiency is lower, and later stage crushing treatment needs transfer device to handle, the product production continuity is poor, reduce actual production's efficiency.

Disclosure of Invention

The invention aims to solve the problems of low efficiency and complex operation of drying and crushing of heparin sodium in the prior art, and provides a drying and crushing device for producing heparin sodium.

In order to achieve the purpose, the invention adopts the following technical scheme:

a drying and crushing device for heparin sodium production comprises a concentration box, a drying box and a crushing box which are sequentially communicated, a base is arranged at the bottom of the drying box, a first communicating hole is formed in the center of the bottom of the concentration box and communicated with the drying box, steam outlets are formed in two sides of the upper end of the drying box, a second communicating hole is formed in one side of the bottom of the drying box and communicated with one side of the upper end of the crushing box, a hollow centrifugal column is connected to the center of the lower end of the interior of the drying box in a rotating mode, a centrifugal motor is arranged in the base, an output shaft of the centrifugal motor extends into the interior of the drying box, the output shaft of the centrifugal motor is connected with the centrifugal column through a rotating belt, a centrifugal disc is arranged at the upper end of the centrifugal column, a centrifugal barrel with a hollowed-out side wall is connected to the center above the centrifugal disc, a plurality of dispersing grooves are formed in the upper surface of the centrifugal disc from the center to the periphery, and the upper end of the centrifugal barrel is slidably connected with the top of the drying box, first opening is linked together with centrifugation bucket upper end central authorities, the inside first breather pipe that is provided with of centrifugation bucket, the outside middle section of centrifugation bucket is provided with round annular breather pipe, annular breather pipe both sides lower extreme symmetry intercommunication has the second breather pipe, first breather pipe lower extreme passes the centrifugal disk and rotates with the centrifugal disk to be connected, first breather pipe and second breather pipe bottom are passed the drying cabinet and are extended to the inside and air heater that is linked together of base, first breather pipe sets up a plurality of first gas pockets all around, and annular breather pipe is close to centrifugation bucket one side and sets up a plurality of second gas pockets, set up the one deck electric heat layer on the drying cabinet inner wall.

Preferably, sliding connection has round annular scraper blade on the drying cabinet inner wall, drying cabinet top bilateral symmetry is provided with the cylinder, the cylinder is connected with annular scraper blade upper end through the telescopic link.

Preferably, an air exhaust fan is arranged in the steam outlet, and a filter screen layer is arranged at the lower end of the air exhaust fan.

Preferably, the first air blowing port is arranged obliquely downwards, the second air blowing port is arranged obliquely downwards to one side, and the top end of the first vent pipe is provided with an inclined plate which is inclined downwards from the center to the periphery.

Preferably, the periphery of the centrifugal disc is bent in an upward inclined manner.

Preferably, a first feed inlet is formed in one side of the top end of the concentration box, a stirring motor is arranged in the center above the top end of the concentration box and connected with a first rotating shaft arranged inside the concentration box, electric heating plates are arranged on the periphery of the first rotating shaft, and a liquid separating mechanism is arranged at the position of the first communication port and communicated with the drying box.

Preferably, divide the liquid mechanism and include that the inside second pivot of rotating the connection of first intercommunication mouth and the branch material leaf that the second pivot set up all around, divide material leaf and first intercommunication mouth inner wall sliding connection, the second pivot is connected with the outside branch material motor of concentrator box.

Preferably, smash case one side upper end and be provided with the second feed inlet, be provided with the round wearing layer on the lateral wall of crushing incasement portion central authorities, wearing layer central authorities are provided with the three grinding roller that is the inverted triangle and arranges, it is provided with the second discharge gate to smash bottom of the case portion one side.

Preferably, a screening net layer is arranged below the grinding roller, the screening net layer is inclined, a first discharge hole is formed in one side wall of the inclined lower end of the screening net layer, and a vibrator is arranged at the bottom of the screening net layer.

Preferably, a heating layer is arranged inside the grinding roller.

Compared with the prior art, the invention provides a drying and crushing device for heparin sodium production, which has the following beneficial effects:

1. the heparin sodium solution can be subjected to high-temperature centrifugal treatment through the arrangement of a centrifugal barrel, a centrifugal disc, a centrifugal column, a rotating belt, a first vent pipe, a first air blowing port, a second vent pipe, an annular vent pipe, a second air blowing port and an electric heating layer in a drying box, the solution is centrifugally thrown out, solvent components in the solution are quickly evaporated through hot air blowing, and heparin sodium solid particles enter the bottom of the drying box along with downward hot air, so that the efficiency of heparin sodium drying is improved;

2. through the arrangement of the stirring motor, the first rotating shaft, the electric heating plate, the first communication port, the second rotating shaft and the distributing blade in the concentrating box, primary evaporation concentration can be effectively carried out on the heparin sodium extracting solution, the falling speed of the concentrated heparin sodium is controlled, the density of liquid drops thrown out in later-stage centrifugation is conveniently controlled, the drying efficiency is improved, and meanwhile, the obtained heparin sodium is ensured to be in a dispersed powder shape, so that later-stage grinding is facilitated;

3. through the setting of grinding layer, grinding roller, zone of heating, screening stratum reticulare, first discharge gate, second discharge gate, electromagnetic shaker in smashing the case, can effectively grind the heparin sodium after the drying and smash, promote the fineness of heparin sodium to sieve through the screening stratum reticulare, with substandard continuation grinding, guarantee the stability of gained heparin sodium product.

The device has the advantages that the design is reasonable, the use is convenient, the heparin sodium solution can be effectively dried and crushed, the drying efficiency is high, the production and processing continuity is good, the stability of the obtained heparin sodium powder product is high, and the large-scale production and use are facilitated.

Drawings

FIG. 1 is a schematic front sectional view of the present invention;

FIG. 2 is a schematic side view of the cross-sectional structure of the present invention;

FIG. 3 is a schematic structural view of a front cross section of the drying box of the present invention;

FIG. 4 is a schematic top sectional view of the drying box of the present invention;

FIG. 5 is a schematic view of the front cross-sectional structure of the concentrating tank of the present invention;

FIG. 6 is a schematic view of the front cross-sectional structure of the crushing box of the present invention.

In the figure: 1. a drying oven; 2. a concentration tank; 3. a crushing box; 4. a base; 5. a hot air blower; 6. a centrifugal motor; 7. a first feed port; 8. a stirring motor; 9. a first rotating shaft; 10. an electric hot plate; 11. a first communication port; 12. a second rotating shaft; 13. separating leaves; 14. a centrifuge bucket; 15. a centrifugal pan; 16. a centrifugal column; 17. rotating the belt; 18. a first vent pipe; 19. a first air blowing port; 20. a second vent pipe; 21. an annular vent pipe; 22. a second air blowing port; 23. an electric heating layer; 24. an annular scraper; 25. a cylinder; 26. a telescopic rod; 27. a steam outlet; 28. an air extracting fan; 29. a filter screen layer; 30. an inclined plate; 31. a second communication port; 32. a second feed port; 33. a polishing layer; 34. a grinding roller; 35. a heating layer; 36. screening the net layer; 37 a first discharge port; 38. a second discharge port; 39. a material distributing motor; 40. a dispersion tank; 41. a vibrator.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.

Example 1:

referring to fig. 1-6, a drying and pulverizing device for heparin sodium production, comprises a concentration box 2, a drying box 1 and a pulverizing box 3 which are sequentially communicated, a base 4 is arranged at the bottom of the drying box 1, a first communicating port 11 is arranged at the center of the bottom of the concentration box 2 and communicated with the drying box 1, steam outlets 27 are arranged at two sides of the upper end of the drying box 1, a second communicating port 31 is arranged at one side of the bottom of the drying box 1 and communicated with one side of the upper end of the pulverizing box 3, a hollow centrifugal column 16 is rotatably connected to the center of the lower end of the interior of the drying box 1, a centrifugal motor 6 is arranged in the base 4, an output shaft of the centrifugal motor 6 extends into the interior of the drying box 1, an output shaft of the centrifugal motor 6 is connected with the centrifugal column 16 through a rotating belt 17, a centrifugal disc 15 is arranged at the upper end of the centrifugal column 16, and a centrifugal barrel 14 with a hollow-shaped side wall is connected to the center above the centrifugal disc 15, a plurality of dispersing grooves 40 are arranged on the upper surface of the centrifugal disc 15 from the center to the periphery, the upper end of the centrifugal barrel 14 is connected with the top of the drying box 1 in a sliding way, the first communication port 11 is communicated with the center of the upper end of the centrifugal barrel 14, a first vent pipe 18 is arranged inside the centrifugal barrel 14, a ring of annular vent pipes 21 are arranged at the middle section of the outer part of the centrifugal barrel 14, the lower ends of the two sides of the annular vent pipes 21 are symmetrically communicated with second vent pipes 20, the lower end of the first vent pipe 18 penetrates through the centrifugal disc 15 and is connected with the centrifugal disc 15 in a rotating way, the bottom ends of the first vent pipe 18 and the second vent pipe 20 penetrate through the drying box 1 and extend to the inside of the base 4 to be communicated with the air heater 5, a plurality of first air blowing openings 19 are formed in the periphery of the first air pipe 18, a plurality of second air blowing openings 22 are formed in one side, close to the centrifugal barrel 14, of the annular air pipe 21, and a layer of electric heating layer 23 is arranged on the inner wall of the drying box 1.

The falling solution can be centrifuged and thrown out at a high speed through the centrifugal disc 15 and the centrifugal barrel 14, the contact area of the solution and hot air is increased, and the drying efficiency is improved.

Example 2:

referring to fig. 1-6, this embodiment is substantially the same as embodiment 1, and preferably, a ring of annular scraping plates 24 are slidably connected to the inner wall of the drying box 1, air cylinders 25 are symmetrically arranged on both sides of the top end of the drying box 1, and the air cylinders 25 are connected to the upper ends of the annular scraping plates 24 through telescopic rods 26. Can effectively scrape off the heparin sodium powder that bonds on 1 lateral wall of drying cabinet, conveniently collect.

In order to facilitate the rapid steam overflow, preferably, a suction fan 28 is arranged inside the steam outlet 27, and a filter screen layer 29 is arranged at the lower end of the suction fan 28.

In order to make the heparin sodium solid fall down and facilitate collection, it is preferable that the first air blowing port 19 is disposed obliquely downward, the second air blowing port 22 is disposed obliquely downward to one side, and in order to facilitate the solution to be centrifugally thrown out after rapidly contacting the wall of the centrifugal tub 14 when falling into the centrifugal tub 14, the top end of the first air pipe 18 is provided with an inclined plate 30 inclined downward from the center to the periphery.

In order to control the centrifugal disk 15 to centrifugally throw out the liquid, it is preferable that the periphery of the centrifugal disk 15 is bent in an upward inclined manner.

Example 3:

referring to fig. 5, in this embodiment, basically the same as that in embodiment 1, preferably, a first feeding hole 7 is disposed on one side of the top end of the concentrating tank 2, a stirring motor 8 is disposed at the center above the top end of the concentrating tank 2, the stirring motor 8 is connected with a first rotating shaft 9 disposed inside the concentrating tank 2, electric heating plates 10 are disposed around the first rotating shaft 9, and a liquid separating mechanism disposed at a first communication port 11 is communicated with the drying tank 1. Effectively carry out preliminary concentration to solution, make things convenient for later stage drying process.

In order to control the falling speed of the solution and further control the effect of easy centrifugal drying, it is preferable that the liquid separating mechanism includes a second rotating shaft 12 rotatably connected to the inside of the first communicating port 11 and a separating blade 13 disposed around the second rotating shaft 12, the separating blade 13 is slidably connected to the inner wall of the first communicating port 11, and the second rotating shaft 12 is connected to a separating motor 39 outside the concentrating tank 2.

Example 4:

referring to fig. 6, this embodiment is substantially the same as embodiment 1, and preferably, the upper end of one side of the pulverizing box 3 is provided with a second feeding hole 32, a circle of grinding layer 33 is arranged on the side wall of the center inside the pulverizing box 3, the center of the grinding layer 33 is provided with three grinding rollers 34 arranged in an inverted triangle, and one side of the bottom of the pulverizing box 3 is provided with a second discharging hole 38, so that heparin sodium falling into the pulverizing box 3 can be effectively and rapidly pulverized, and the use continuity of the device is improved.

In order to facilitate the screening of the heparin sodium powder and control the fineness of the heparin sodium powder, preferably, a screen mesh layer 36 is arranged below the grinding roller 34, the screen mesh layer 36 is inclined, a first discharge hole 37 is arranged on one side wall of the inclined lower end of the screen mesh layer 36, and a vibrator 41 is arranged at the bottom of the screen mesh layer 36.

In order to further ensure the completeness of the heparin sodium drying and simultaneously improve the grinding efficiency, it is preferable that a heating layer 35 is disposed inside the grinding roller 34.

The working principle is as follows: when in use, a heparin sodium solution is added into the concentration box 2, the stirring motor 8 is started to electrify the electric heating plate 10, so that the heparin sodium solution is stirred, heated and concentrated, after the heparin sodium solution is concentrated to a certain degree, the material distribution motor 39 and the centrifugal motor 6 are started, the hot air fan 5 is started at the same time, the electric heating layer 23 is electrified and heated, the concentrated heparin sodium solution slowly falls into the centrifugal barrel 14 through the material distribution blade 13, after the heparin sodium solution is close to the side wall of the centrifugal barrel 14 through the inclined plate 30, the heparin sodium solution is centrifuged at a high speed through a hollow position and is thrown out for drying, part of the solution falls onto the centrifugal disk 15 and is centrifuged and thrown out through the dispersion groove 40, after the liquid drops thrown out are dried through the hot air drying and the electric heating layer 23, the air suction fan 28 is started to discharge steam, the dried solid falls into the crushing box 3 after being gathered downwards along with the direction of hot air, the air cylinder 25 is started in time in the drying process, the residual heparin sodium on the inner wall of the drying box 1 is scraped through the annular scraper 24, the heparin sodium enters the crushing box 3, the grinding roller 34 and the vibrator 41 are started, the heparin sodium is ground and sieved by the sieving net layer 36, the sieved powder is collected, and the heparin sodium which does not pass through the sieving is continuously ground.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.