阅读说明：本技术 过氧化氢消毒剂组合物 (Hydrogen peroxide disinfectant compositions ) 是由 M·A·本特雷 江肖 M·加里森 于 2020-02-26 设计创作，主要内容包括：本发明提供一种消毒剂组合物,其包含：a)有效量的过氧化氢源,b)至少一种芳族醇和至少一种二醇或二醇醚的共混物,c)至少一种非离子和/或阴离子表面活性剂,和d)至少一种酸。此外,还提供一种使用该消毒剂组合物的方法,其中该组合物可以施用到任何表面和有效地杀灭大部分结核病和/或土分枝杆菌微生物；在5分钟或更少的接触时间产生>5的对数减少。(The present invention provides a disinfectant composition comprising: a) an effective amount of a source of hydrogen peroxide, b) a blend of at least one aromatic alcohol and at least one glycol or glycol ether, c) at least one nonionic and/or anionic surfactant, and d) at least one acid. Further, a method of using the disinfectant composition is provided, wherein the composition can be applied to any surface and is effective in killing a majority of tuberculosis and/or Mycobacterium terrae microorganisms; a >5 log reduction was produced at contact times of 5 minutes or less.)

1. A disinfectant composition comprising: a) an effective amount of a hydrogen peroxide source, b) at least one aromatic alcohol, c) at least one glycol or glycol ether, d) at least one nonionic and/or anionic surfactant, and e) at least one acid.

2. The disinfectant composition according to claim 1, wherein the source of hydrogen peroxide comprises a hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

3. A disinfectant composition according to claim 2, wherein the concentration of the hydrogen peroxide source is from 0.01 w/w% to about 90 w/w% based on the total weight of the composition.

4. The disinfectant composition according to claim 1, wherein the at least one aromatic alcohol comprises anisyl alcohol, benzyl alcohol, phenoxyethanol, vanillyl alcohol, phenol, polyphenol, derivatives thereof, or salts thereof.

5. The disinfectant composition according to claim 4, wherein the at least one aromatic alcohol comprises benzyl alcohol and/or phenoxyethanol, present in an amount of about 0.01 to 50 w/w% of the total composition.

6. The disinfectant composition according to claim 1, wherein the at least one glycol or glycol ether comprises ethylene glycol, propylene glycol, butylene glycol, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono n-butyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol n-butyl ether, tripropylene glycol methyl ether, dipropylene glycol butyl ether, triethylene glycol monobutyl ether, or combinations thereof, present in an amount of about 0.01 to 50 w/w% of the total composition.

7. The disinfectant composition according to claim 1, wherein at least one aromatic alcohol and at least one glycol or glycol ether are present as a blend, and wherein the blending ratio is from 1:100 to 100: 1.

8. The disinfectant composition according to claim 7, wherein the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.01 to 90 w/w% of the total composition.

9. The disinfectant composition according to claim 8, wherein the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.1 to 75 w/w% of the total composition.

10. A disinfectant composition according to claim 1 wherein at least one nonionic and/or anionic surfactant is present in an amount wherein the total amount of surfactant present is from 0.01 to 15 w/w% of the total composition.

11. The disinfectant composition according to claim 1, wherein the nonionic surfactant comprises an ethoxylate aliphatic alcohol, a polyoxyethylene surfactant, a polyethylene glycol ester, a sorbitan ester and ethoxylate derivatives thereof, a glycol ester, a carboxyamide, a monoalkanolamine condensate, a polyoxyethylene fatty acid amide, or combinations thereof.

12. A disinfectant composition according to claim 11, wherein the non-ionic surfactant comprises octanoyl/decanoyl glycoside, C₁₂-C₁₅Ethoxylated alcohols, C₁₂-C₁₄A secondary ethoxylated alcohol 70%, a 2-ethylhexanol EO-PO nonionic surfactant, or a combination thereof.

13. The disinfectant composition according to claim 1, wherein the anionic surfactant comprises a linear alkylbenzene sulfonic acid, an alkyl sulfate, an alkanolamide sulfate, an ethoxylated alkylphenol, or a combination thereof.

14. The disinfectant composition according to claim 1, wherein the at least one acid comprises an organic acid, an inorganic acid, a carboxylic acid, a mineral acid, a non-surfactant sulfonic acid, or a salt thereof.

15. The disinfectant composition according to claim 14, wherein the at least one acid comprises citric acid, lactic acid, glycolic acid, tartaric acid, formic acid, acetic acid, phosphoric acid, oxalic acid, propionic acid, or methane sulfonic acid.

16. A disinfectant composition according to claim 14 wherein the total amount of acid is from 0.01 to 15 w/w% of the total composition.

17. The disinfectant composition according to claim 1, further comprising a linear or branched water soluble alcohol.

18. A disinfectant composition according to claim 1 further comprising a peroxide stabiliser and/or a chelating agent; wherein the stabilizer and/or chelating agent is present in an amount of from 0.01 to 5 w/w% based on the weight of the total composition.

19. A disinfectant composition according to claim 18, wherein the peroxide stabiliser and/or chelating agent comprises for example phosphoric or phosphonic acid, ethylenediaminetetraacetic acid (EDTA), ethylenediamine-N, N' -disuccinic acid, 1-hydroxyethane-1, 1-diphosphonic acid (HEDP), or salts thereof.

20. The disinfectant composition according to claim 1, wherein the pH of the composition is from about 0 to about 5.

21. The disinfectant composition according to claim 1, further comprising a second biocide present in an amount of 0.01 to 40 w/w%.

22. A disinfectant composition according to claim 1, wherein the composition is a concentrate.

23. The disinfectant composition according to claim 1, wherein the composition is a ready-to-use composition diluted with an aqueous solvent, a non-aqueous solvent or a mixture thereof.

24. The disinfectant composition according to claim 1, wherein said composition is effective against one or more microorganisms comprising: gram positive bacteria, gram negative bacteria, viruses, fungi, mildew, mold, or combinations thereof.

25. The disinfectant composition according to claim 24, wherein the microorganisms comprise staphylococcus, pseudomonas, hepatitis virus, rotavirus, rhinovirus, tuberculo-bacillus, or combinations thereof.

26. A disinfectant composition according to claim 25, wherein the composition is effective against tuberculosis and/or mycobacterium terrae.

27. A disinfectant composition according to claim 1 wherein the composition provides an effective kill of >5 log reduction at a contact time of 5 minutes or less.

28. A disinfectant composition according to claim 27 wherein the composition provides an effective kill of >5 log reduction at a contact time of 3 minutes.

29. A disinfectant composition according to claim 1 comprising: a) an effective amount of a source of hydrogen peroxide, wherein the source comprises a hydrogen peroxide solution; b) at least one aromatic alcohol, wherein the alcohol comprises benzyl alcohol and/or phenoxyethanol; c) at least one glycol or glycol ether, wherein the glycol comprises diethylene glycol monobutyl ether; d) at least one non-ionic and/or anionic surfactant, wherein said surfactant comprises C₁₂-C₁₅Ethoxylated alcohols, C₁₂-C₁₄Sec-ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic TableSurfactants, caprylyl/decyl glucoside, and/or linear alkylbenzene sulfonic acids; and e) at least one acid, wherein the acid comprises methane sulfonic acid; and wherein the composition is effective against tuberculosis and/or mycobacterium terrae.

30. A method of disinfecting a surface against tuberculosis and/or mycobacterium terrae, wherein the method comprises applying to the surface an effective amount of a disinfectant composition according to any one of claims 1 to 28, which amount is effective to kill a majority of microorganisms located on the surface.

31. A method according to claim 29, wherein the method comprises a disinfectant composition which inhibits the growth of one or more microorganisms therein and/or reduces the number of viable microorganisms.

32. The method of claim 30, wherein the disinfectant composition according to any of claims 1-28 provides a >5 log reduction in contact time of 5 minutes or less.

33. The method of claim 30, wherein the surface comprises a floor, wall, countertop, appliance, fixture, fabric, textile, or other hard or soft surface.

34. A method of enhancing the disinfectant properties of a source of hydrogen peroxide, wherein the method comprises adding a sufficient amount of b) at least one aromatic alcohol with the source of hydrogen peroxide; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid, and wherein the composition is applied to a surface.

35. A disinfecting composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid; wherein the composition is effective against tuberculosis and/or mycobacterium terrae; and wherein the composition can be diluted with a solvent to form a ready-to-use composition.

36. The sanitizing composition according to claim 35, wherein the solvent comprises a source of hydrogen peroxide, an aqueous solvent, a non-aqueous solvent, or a mixture thereof.

37. The sanitizing composition according to claim 36, wherein the source of hydrogen peroxide comprises a hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

38. A two-component disinfectant, the disinfectant comprising: a first container comprising a) a biocidal amount of hydrogen peroxide, and a solvent; and a second container comprising b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid.

39. The two-component disinfectant of claim 38 wherein the disinfectant is effective against tuberculosis and/or mycobacterium terreus, and wherein the disinfectant provides a >5 log reduction in contact time of 5 minutes or less.

40. The two-component disinfectant of claim 39 wherein the disinfectant provides a log reduction of >5 at a contact time of 3 minutes.

41. An additive for a disinfectant composition, the additive comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid; wherein the additive, when combined with a disinfecting active ingredient, enhances the disinfecting performance of the composition.

42. An additive for disinfectant compositions according to claim 41, wherein said disinfectant active comprises hydrogen peroxide solution, alcohol, bleach or phenol.

43. An additive for disinfectant compositions according to claim 42, wherein the source of hydrogen peroxide comprises a hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

Technical Field

The present invention relates to a disinfectant composition effective against tuberculosis bacteria, comprising hydrogen peroxide and a novel solvent system.

Background

Of the known disinfectants and antimicrobials, hydrogen peroxide is the preferred option, not only because of its potential as a biocide, but also because it decomposes into non-toxic oxygen and water with low toxicity. Furthermore, hydrogen peroxide is an ideal active ingredient for disinfectant formulations on non-hard porous surfaces because of its inherent ability to kill a wide range of microorganisms and its low toxicity product.

Unfortunately, hydrogen peroxide alone cannot kill higher levels of organisms such as tuberculosis bacteria, and in particular it is difficult to show the desired shorter kill times (<5 minutes). Therefore, hydrogen peroxide itself is not very effective against certain organisms. It does not show efficacy against tuberculosis pathogens, even when contacted for a long time at high activity levels. Furthermore, most of the commercially available hydrogen peroxide based products are not able to kill tuberculosis pathogens (TB) on hard surfaces within a short contact time.

There is a need in the art to provide disinfectant products for the medical disinfectant market that are effective in killing tuberculosis pathogens and provide rapid disinfecting performance after application to a surface.

Disclosure of Invention

It has now surprisingly been found that the combination of hydrogen peroxide and a novel solvent system is effective against tuberculosis germs with an effective kill of >5 log reduction against tuberculosis pathogens at a contact kill time of 5 minutes or less.

The present invention addresses the need for a disinfectant composition containing hydrogen peroxide that is effective against tuberculosis-causing bacteria even at high active ingredient levels. The present invention provides a disinfectant composition effective against tuberculosis and/or mycobacterium terreus (m.terrae) comprising an acidified hydrogen peroxide solution having a pH of 0-5, and a novel solvent system. The composition provides an effective kill of >5 log reduction against tuberculosis pathogens at a contact kill time of 5 minutes or less.

In one embodiment, the present invention provides a disinfectant composition comprising: a) an effective amount of a hydrogen peroxide source, b) at least one aromatic alcohol, c) at least one glycol or glycol ether, d) at least one nonionic and/or anionic surfactant, and e) at least one acid.

In one embodiment, the source of hydrogen peroxide comprises a hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, urea hydrogen peroxide or a peroxide salt, a hydrated salt thereof, or a combination thereof.

In one embodiment, the concentration of the hydrogen peroxide source is from 0.01 w/w% to about 90 w/w% of the total weight of the composition.

In one embodiment, at least one aromatic alcohol is present, which includes anisyl alcohol, benzyl alcohol, phenoxyethanol, vanillyl alcohol, phenol, polyphenol, derivatives thereof, or salts thereof.

In another embodiment, at least one glycol or glycol ether is present, which includes butylene glycol, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether, dipropylene glycol methyl ether, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol n-butyl ether, tripropylene glycol methyl ether, triethylene glycol monobutyl ether, or a combination thereof.

In a particular embodiment, the at least one aromatic alcohol and the at least one glycol or glycol ether are present as a blend, wherein the blending ratio is from 1:100 to 100: 1.

In one embodiment, the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.01 to 90 w/w% of the total composition.

In a particular embodiment, the at least one nonionic surfactant and/or anionic surfactant is present in an amount wherein the total amount of surfactant present is from 0.01 w/w% to 15 w/w% of the total composition.

In another embodiment, the at least one acid comprises an organic acid, an inorganic acid, a carboxylic acid, a mineral acid, a non-surfactant sulfonic acid, or a salt thereof.

In one embodiment, the total amount of acid is present in an amount of 0.01 to 15 w/w% of the total composition.

In yet another embodiment, the composition further comprises a peroxide stabilizer and/or a chelating agent; wherein the stabilizer and/or chelating agent is present in an amount of from 0.01 to 5 w/w% based on the weight of the total composition.

In one embodiment, the composition is a composition having a pH of from about 0 to about 5.

In yet another embodiment, the composition further comprises a second biocide present in an amount of 0.01 to 20 w/w%.

In one embodiment, the composition comprises a concentrate, and in another embodiment, the composition comprises a ready-to-use composition diluted with an aqueous solvent, a non-aqueous solvent, or a mixture thereof.

In another embodiment, the composition is effective against one or more microorganisms comprising: gram positive bacteria (gram positive bacteria), gram negative bacteria (gram negative bacteria), viruses, fungi, mildew (milew), molds (mold), or combinations thereof.

In another embodiment, the composition is effective against tuberculosis and/or mycobacterium terrae.

In a specific embodiment, the composition provides an effective kill of >5 log reduction at a contact time of 5 minutes or less.

In one embodiment, the present invention provides a disinfectant composition according to the present invention comprising: a) an effective amount of a source of hydrogen peroxide, wherein the source comprises a hydrogen peroxide solution; b) at least one aromatic alcohol, wherein the alcohol comprises benzyl alcohol andor phenoxyethanol; c) at least one glycol or glycol ether, wherein the glycol comprises diethylene glycol monobutyl ether, triethylene glycol monobutyl ether; d) at least one non-ionic and/or anionic surfactant, wherein said surfactant comprises C₁₂-C₁₅Ethoxylated alcohols, C₁₂-C₁₄Secondary ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl/decyl glucoside, and/or linear alkylbenzene sulfonic acid; and e) at least one acid, wherein the acid comprises methane sulfonic acid; and wherein the composition is effective against tuberculosis and/or mycobacterium terrae.

In another embodiment, the present invention provides a method of disinfecting a surface against tuberculosis and/or mycobacterium terrae, wherein the method comprises adding an effective amount of a disinfectant composition according to the present invention and applying the composition to the surface in an amount effective to kill a substantial portion of the microorganisms located on the surface.

In another embodiment, the method includes a disinfectant composition to inhibit the growth of one or more microorganisms therein and/or to reduce the number of viable microorganisms.

In one embodiment, the surface is a hard or soft surface, including a floor, wall, countertop, appliance, fixture, fabric, textile, or other hard or soft surface.

In yet another embodiment, the present invention provides a method of enhancing the disinfectant performance of a source of hydrogen peroxide, wherein the method comprises adding a sufficient amount of b) at least one aromatic alcohol with the source of hydrogen peroxide; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid, and wherein the composition is applied to a surface.

In another embodiment, the present invention provides a disinfecting composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid; wherein the composition is effective against tuberculosis and/or mycobacterium terrae; and wherein the composition can be diluted with a solvent to form a ready-to-use composition.

In one embodiment, the present invention provides a two-component disinfectant comprising: a first container comprising a) a biocidal amount of hydrogen peroxide, and a solvent; and a second container comprising b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid.

In one embodiment, the two-component disinfectant is effective against tuberculosis and/or mycobacterium terreus, wherein the disinfectant provides a >5 log reduction in contact time of 5 minutes or less.

In yet another embodiment, the present invention provides an additive for disinfectant compositions, the additive comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid; wherein the additive, when combined with a disinfecting active ingredient, enhances the disinfecting performance of the composition.

In one embodiment, the disinfecting active ingredient comprises a hydrogen peroxide solution, an alcohol, a bleaching agent, an organic acid or a phenol.

Detailed Description

The present invention provides a disinfectant composition comprising a source of hydrogen peroxide which is effective against tuberculosis and/or mycobacterium terreus with a >5 log reduction at a contact time of 5 minutes or less. These and other aspects will become apparent upon reading the detailed description of the invention.

As used herein, the term "effective amount" refers to any amount that will bring about the desired effect based on the known purpose and function of the ingredient and the application of the composition. The effective amount of the composition will be able to be determined by one skilled in the art without the need for inventive experimentation.

It has now surprisingly been found that combining an acidified hydrogen peroxide solution having a pH of 0-5 and a novel organic solvent system; compositions are provided that exhibit >5 log reduction in anti-mycobacterium terrae and/or tuberculosis effects at contact times of 5 minutes or less.

One aspect of the present invention provides a disinfectant composition comprising: a) an effective amount of a hydrogen peroxide source, b) at least one aromatic alcohol, c) at least one glycol or glycol ether, d) at least one nonionic and/or anionic surfactant, and e) at least one acid.

The disinfectant compositions described in the present invention are concentrates and/or ready-to-use compositions.

Typically, the source of hydrogen peroxide includes, but is not limited to, a hydrogen peroxide solution, a percarbonate (i.e., sodium percarbonate, potassium percarbonate), a perborate (i.e., sodium perborate, potassium perborate), urea hydrogen peroxide, or a peroxide salt, a hydrated salt thereof, or a combination thereof, and the like.

Typically, the concentration of the hydrogen peroxide source is from 0.01 w/w% to about 90 w/w%, based on the total weight of the composition. The hydrogen peroxide source in the disinfectant composition is typically present in an amount of from 0.1 to about 50 w/w% based on the total weight of the composition. Suitably, the concentration of the hydrogen peroxide source is from 0.5 w/w% to about 20 w/w% based on the total weight of the composition. Desirably, the concentration of the hydrogen peroxide source is from 0.01 w/w% to about 15 w/w% of the total weight of the composition. In the ready-to-use form, typically the amount of hydrogen peroxide is from 0.01 to 15 w/w% of the total composition; suitably from 0.1 to 10 w/w%, or desirably from 0.01 to 7 w/w%.

Typically, at least one aromatic alcohol is present in the composition. Examples include, but are not limited to, anisyl alcohol, benzyl alcohol, phenoxyethanol, vanillyl alcohol, phenols, polyphenols, derivatives thereof, or salts thereof, and the like. Suitably, the at least one aromatic alcohol comprises benzyl alcohol and/or phenoxyethanol.

Typically, the at least one aromatic alcohol is present in an amount of about 0.01 to 50 w/w% based on the weight of the total composition. Suitably, the at least one aromatic alcohol is present in an amount of from about 0.1 to 25 w/w%, desirably from about 0.1 to 15%, based on the weight of the total composition.

Typically, examples of glycols or glycol ethers include, but are not limited to, at least one glycol or glycol ether comprising: butylene glycol, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono n-butyl ether, dipropylene glycol methyl ether, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol n-butyl ether, tripropylene glycol methyl ether, triethylene glycol monobutyl ether, or combinations thereof, and the like. Suitably, the at least one glycol or glycol ether comprises diethylene glycol monobutyl ether, and/or triethylene glycol monobutyl ether.

Typically, the at least one glycol or glycol ether is present in an amount of about 0.01 to 50 w/w% based on the weight of the total composition. Suitably, the at least one glycol or glycol ether is present in an amount of from about 0.1 to 25 w/w%; or desirably from about 0.1 to 15 w/w% based on the weight of the total composition.

If desired, the composition comprises a novel solvent system whereby the system is a blend of a) at least one aromatic alcohol, and/or b) at least one glycol or glycol ether, or c) at least one aromatic alcohol and at least one glycol or glycol ether. Typically the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in a ratio of from 1:100 to 100:1, if desired. Suitably, the ratio of the blend is from 1:50 to 50: 1; or desirably the ratio of the blend is 1:20 to 20: 1.

Typically, the blend of at least one aromatic alcohol and at least one glycol or glycol ether is present in an amount of about 0.01 to 90 w/w% of the total composition. Suitably the blend is present in an amount of from about 0.1 to 75 w/w%, or suitably the blend is present in an amount of from about 0.1 to 50 w/w%, based on the weight of the total composition.

For example, the disinfectant composition comprises a blend of benzyl alcohol and/or phenoxyethanol with diethylene glycol monobutyl ether and/or triethylene glycol monobutyl ether in a 1:100-100:1 ratio; typical total amounts of such blends are from about 0.01 to 90 w/w% based on the weight of the total composition.

If desired, the composition further comprises at least one nonionic surfactant and/or anionic surfactant, whereby the surfactants are present in a total amount of from 0.01 to 15 w/w%, suitably from about 0.01 to 10 w/w% of the total composition.

Typically, the nonionic surfactant includes, but is not limited to, at least one of the following: ethoxylated aliphatic alcohols, polyoxyethylene surfactants, polyethylene glycol esters, sorbitan esters and their ethoxylate derivatives, glycol esters, carboxyamides, monoalkanolamine condensates, polyoxyethylene fatty acid amides, or combinations thereof and the like.

Suitably, examples of the at least one nonionic surfactant include, but are not limited to, octanoyl/decanoyl glycoside, C₈-C₁₅Ethoxylated alcohols, C₈-C₁₄Secondary ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic surfactant, C₈-C₁₄Alkylated polyethylene glycols, C₈-C₁₄Alkylated polypropylene glycols, polyoxyethylene glycol alkylphenol ethers, and glycoside alkyl ethers, polyoxyethylene glycol alkyl ethers, octaethylene glycol monododecyl ether, pentaethylene glycol monododecyl ether, polyoxypropylene glycol alkyl ethers, glycoside alkyl ethers, decyl glycoside, lauryl glycoside, octyl glycoside, polyoxyethylene glycol octylphenol ether, polyoxyethylene glycol alkylphenol ethers, glyceryl esters, polyglyceryl esters, glyceryl laurate, polyoxyethylene glycol sorbitan alkyl esters, dodecyldimethyl amine oxide, block copolymers of polyethylene glycol and polypropylene glycol, poloxamers and polyethoxylated tallow amine (POEA), or mixtures thereof and the like.

Typically, examples of anionic surfactants include, but are not limited to, at least one anionic surfactant including, but not limited to, linear alkylbenzene sulfonic acid, alkylbenzene sulfonate, alkyl sulfate/sulfonate, alkanolamide sulfate, ethoxylated alkyl phenol, linear alkylbenzene sulfonate, alkyl sulfate, alkoxylated alkyl sulfate, combinations thereof, or the like.

The composition contains at least one acid including, but not limited to, organic acids, inorganic acids, carboxylic acids, mineral acids, non-surfactant sulfonic acids, or salts thereof, and the like. The total amount of acid present in the composition is from 0.01 to 15 w/w% of the total composition. For concentrated or ready-to-use forms, suitably from 0.01 w/w% to 10 w/w%; desirably from 0.01 w/w% to 5 w/w%.

Suitably, examples of the at least one acid include, but are not limited to, citric acid, lactic acid, glycolic acid, tartaric acid, formic acid, acetic acid, phosphoric acid, oxalic acid, propionic acid, or methane sulfonic acid, butyric acid, valeric acid, caproic acid, caprylic acid, succinic acid, glutaric acid, adipic acid, benzoic acid, phthalic acid, mixtures thereof, and the like.

Typically, the pH of the disinfectant composition in concentrated form may be from about 0 to about 5; suitably from 1 to about 3. In the ready-to-use solution, the pH may be from about 0.5 to about 4.5, suitably from 0.5 to 3.

Desirably, one or more additional ingredients may be included in the composition, including, but not limited to, biocides, solvents, corrosion inhibitors, emulsifiers, fragrances, dyes, preservatives, defoamers, thickeners, hydrotropes, secondary biocides, sequestering agents/chelating agents, acid-stable solubilizing agents, aqueous solvents, or mixtures thereof, and the like.

If a stabilizer and/or chelating agent is added, the stabilizer includes, but is not limited to, a peroxide stabilizer, which is present in an amount of 0.01 to 5 w/w% based on the weight of the total composition.

Typically, stabilizers/chelating agents include, but are not limited to, aminocarboxylic acid based products, phosphates and phosphonates, hydroxycarboxylic acid esters, polyacrylates, sugar acrylates (sugar acrylates), polymeric clarifiers, dichlorides, trichlorides, cyanuric acid, organic and/or inorganic sequestering agents, and the like.

Examples of phosphate sequestering agents include inorganic polyphosphates such as Sodium Hexametaphosphate (SHMP), sodium polyphosphate, sodium tripolyphosphate, sodium trimetaphosphate, sodium pyrophosphate, combinations thereof, and the like.

Examples include phosphonated aminopolycarboxylates such as ethylenediamine tetra (methylene phosphonic acid) (EDTMP), diethylenetriamine pentamethylene phosphonic acid (DETMP), aminotri (methylene phosphonic Acid) (ATMP), diethylenetriamine penta (methylene phosphonic acid) (DTPMP), HEDP or salts thereof; combinations thereof, and the like.

Suitably, examples of stabilizers/chelating agents include, but are not limited to, phosphoric acid, 1-hydroxyethylidene bisPhosphonic acid (HEDP), phytic acid, phosphoramidates, phosphonates and sodium glutamate, NaH₂PO₄，Na₅P₃O₁₀Organo phosphonic acids, amino phosphonic acid esters, silver dihydrogen citrate, diphosphonic acid, Ethylene Diamine Tetraacetic Acid (EDTA), N- (hydroxyethyl) -ethylenediamine triacetic acid (HEDTA), tris (methylene phosphoric acid), diethylene triamine penta (methylene phosphoric acid), 2-hydroxyethyl imino bis (ethylene phosphoric acid), citric acid, dipyridylic acid, ethylenediamine-N, N' -disuccinic acid, methyl glycine diacetic acid and their alkali salts, nitrotriacetic acid (NTA), 2-hydroxyethyl imino diacetic acid (HEIDA), and salts thereof, cyclohexane-1, 2-diamino tetramethylene phosphonic acid or hydrosols, diethylene triamine penta (methylene phosphonic acid), colloidal stannates, Diethylene Triamine Pentaacetic Acid (DTPA), citrates, gallates, malates, malonates, oxaloacetate, oxalate, pyruvate, succinate, 2-hydroxypyridine-1-oxide (2-HPNO), hydroxyethylidene diphosphonic acid (HEDP) zinc salt, triethanolamine phosphate, or mixtures thereof, and the like.

Typically, if a biocide is added to the disinfectant composition, the biocide acts as a second biocide in the composition; thus the biocide is present in an amount of 0.01 w/w% -40 w/w%, or suitably 0.01 w/w% to 25 w/w%, based on the weight of the total composition.

Examples of the second biocide include, but are not limited to, halogen-releasing compounds; quaternary ammonium compounds (including quaternary ammonium halides, sulfates, phosphates, nitrates, or combinations thereof; e.g., benzalkonium chloride), isothiazolinones or mixtures thereof, pyrithione, glutaraldehyde, iodopropynyl butylcarbamate (IPBC), polyhexamethylene biguanide (PHMB), bronopol, amines (e.g., bis (3-aminopropyl) dodecylamine), metal salts, poly (oxyethylene (dimethylimino) ethylene (dimethylimino) dichloride), sodium dimethyldithiocarbamate, 2-chloro-4, 6-bis (ethylamino) -5-triazine, oxidizing agents, combinations thereof, and the like.

Examples of halogen-releasing compounds include, but are not limited to, chlorinated isocyanuric acid or salts thereof, isothiazolinones or mixtures of isothiazolinones; halogenated hydantoins, hypochlorous acid or salts thereof, chlorine dioxide, hypobromite, hypobromous acid; and compatible combinations thereof, and the like; substantially free of any peracid-based solution, derivative or salt thereof.

Examples of chlorinated isocyanuric acid or salts thereof include, but are not limited to, for example, trichloroisocyanuric acid (TCCA) and dichloroisocyanuric acid (DCCA); dichloroisocyanurates (e.g., sodium dichloroisocyanurate, potassium dichloroisocyanurate), trichloroisocyanurates (e.g., sodium or potassium trichloroisocyanurate), combinations thereof, and the like.

Examples of chlorinated halogenated hydantoins include both chlorine-and bromine-containing hydantoins such as Bromochlorodimethylhydantoin (BCDMH); dibromodimethylhydantoin (DBDMH), dichlorodimethylhydantoin (DCDMH), Dichloromethylethylhydantoin (DCMEH), combinations thereof, and the like.

Examples of hypochlorite, hypochlorous acid or hypobromous acid and salts thereof include, but are not limited to, lithium hypochlorite, sodium hypochlorite, potassium hypochlorite, magnesium hypochlorite, calcium hypochlorite, combinations thereof, and the like.

Examples of metal salts include, but are not limited to, zinc chloride, zinc oxide, aluminum sulfate, copper citrate, copper EDTA (ethylenediaminetetraacetic acid), copper gluconate, colloidal silver, silver nitrate, potassium monopersulfate, sodium perborate, sodium percarbonate, combinations thereof and the like.

The disinfectant compositions of the present invention are concentrates and/or ready-to-use compositions; the composition thus concentrated is diluted with an aqueous solvent, a non-aqueous solvent or a mixture thereof; to provide ready-to-use compositions for consumer use. The diluted hydrogen peroxide source is present in an amount of from 0.01 to 20 w/w% based on the weight of the total composition; suitably from 0.1 to 15 w/w% based on the weight of the total composition; and desirably from 0.1 to 8 w/w% based on the weight of the total composition.

Typically, the solvent is an aqueous solvent, a non-aqueous solvent, or mixtures thereof, and the like; present in the total composition in an amount equal to 100%. For example, the solvent is a straight or branched water soluble alcohol, water.

Examples of aqueous solvents include, but are not limited to, water, aqueous alcohols, aqueous ammonia, acid solutions, hydrogen peroxide solutions, salt solutions, water-miscible organic solvents, alkanolamines, or glycol ethers, combinations thereof, and the like.

Examples of non-aqueous solvents include, but are not limited to, non-aqueous alcohols, mono-or polyhydric alcohols, alkanolamines, or glycol ethers, any water-immiscible material, mixtures thereof, and the like.

Suitably, the solvent used is water, aqueous alcohol, glycol ether, aromatic alcohol, or a mixture thereof.

Disinfectant compositions are compositions that have efficacy against one or more microorganisms including, but not limited to: gram positive bacteria, gram negative bacteria, viruses, fungi, mildew, mold or combinations thereof and the like.

Specifically, the microorganism includes but is not limited to Staphylococcus (Staphylococcus), Pseudomonas (Pseudomonas), hepatitis virus (hepatitis), rotavirus (rotavirus), rhinovirus (rhinovirus), tuberculosis, or a combination thereof, etc.

Desirably, the disinfectant composition has significant efficacy against tuberculosis bacteria, including but not limited to, mycobacterium terreus. The composition exhibits >5 log reduction against mycobacterium terrestris at contact times of 5 minutes or less. In particular, wherein the disinfectant composition exhibits a >5 log reduction against mycobacterium terreus at a contact time of about 3 minutes.

One aspect of the invention provides a disinfectant composition according to the invention having: a) an effective amount of a source of hydrogen peroxide, wherein the source comprises a hydrogen peroxide solution; b) at least one aromatic alcohol, wherein the alcohol comprises benzyl alcohol and/or phenoxyethanol; c) at least one glycol or glycol ether, wherein the glycol comprises diethylene glycol monobutyl ether, triethylene glycol monobutyl ether; d) at least one non-ionic and/or anionic surfactant, wherein said surfactant comprises C₁₂-C₁₅Ethoxylated alcohols, C₁₂-C₁₄Secondary ethoxylated alcohol 70%, 2-ethylhexanol EO-PO nonionic surfactant, caprylyl/decyl glucoside, and/or linear alkylbenzene sulfonic acid; and e) at least one acid, wherein the acid comprises methane sulfonic acid; wherein the composition is effective against tuberculosis andand/or Mycobacterium terrae.

Another aspect of the invention provides a method of disinfecting tuberculosis and/or mycobacterium terreus, wherein the method comprises adding to a surface an effective amount of a disinfectant composition according to the invention, said amount being effective to kill a substantial proportion of the microorganisms located on said surface.

The method provides a disinfectant composition that inhibits the growth of one or more microorganisms therein and/or reduces the number of viable microorganisms. In particular wherein the disinfectant composition according to the present invention exhibits a log reduction of >5 at a contact time of 5 minutes or less. Suitably wherein the disinfectant composition according to the present invention exhibits a >5 log reduction at a contact time of 3 minutes.

Typically, the surface is any hard or soft surface, including but not limited to floors, walls, countertops, appliances, fixtures, fabrics, textiles, upholstery, other hard surfaces, soft surfaces, or any surface that requires antimicrobial (suitably tuberculobacillus and/or mycobacterium tuberculosis) treatment.

Examples of soft surfaces include, but are not limited to, upholstery, fabric, upholstered benches, sofas, chairs, seating pads, upholstered cushions, pillows, upholstered furniture, fabric window treatments, curtains, draperies, shower curtains, fabric body/laundry/diaper bags, backpacks, fabric baskets, fabric sleeping mats for dogs/pets, blankets, fabric upholstered vehicle seats, fabric stuffed animals, toys, and the like.

For example, the compositions of the present invention provide disinfecting or sanitizing properties to hard, non-porous surfaces. The compositions of the present invention are well suited for disinfecting or sanitizing flooring materials, countertops, ceramic surfaces, metal surfaces, glass surfaces, stone surfaces, and the like.

The composition may be used to clean a surface, destroy microorganisms on a surface, and/or prevent the growth of microorganisms on a surface. Also, the compositions can be used in the food industry to disinfect and sterilize food processing equipment and other food processing surfaces, or to clean produce such as vegetables. The composition can also be used in the health care industry to disinfect surfaces, facilities, devices and medical instruments and devices, and/or to disinfect appliances. The composition may be used in concentrated or diluted form depending on the application.

Mycobacterium terrestris killing the bactericidal and bacteriostatic activity of microbicides was evaluated using OECD quantification methods. The method provides a quantitative assessment of the performance of a liquid antimicrobial substance designed for use on hard, non-porous surfaces against mycobacterium. This method is based on economic cooperation and development Organization (OECD) guidelines and provides a quantitative measure of Log Reduction (LR) as the efficacy of liquid disinfectants. Mycobacterium terrae log₁₀Reduction is often used as a prescreening tool to determine the potential efficacy for tuberculosis (which is generally recognized as more difficult to kill and more difficult to study in the laboratory). Mycobacterium terrae log₁₀The reduction was evaluated using 3 minutes contact time and 5% soil.

In another aspect, the present invention provides a method of enhancing the disinfectant performance of a source of hydrogen peroxide, wherein the method comprises adding a sufficient amount of b) at least one aromatic alcohol with the source of hydrogen peroxide; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid, and wherein the composition is applied to a surface.

In yet another aspect, the present invention provides a disinfecting composition comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid; wherein the composition is effective against tuberculosis and/or mycobacterium terrae; and wherein the composition can be diluted with a solvent to form a ready-to-use composition.

Solvents used to form the ready-to-use composition include, but are not limited to, a source of hydrogen peroxide, an aqueous solvent, a non-aqueous solvent, or mixtures thereof. Examples of such solvents are those previously mentioned.

In another aspect, the present invention provides a two-component disinfectant comprising: a first container comprising a) a biocidal amount of hydrogen peroxide, and a solvent; and a second container comprising b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid.

Typically, the two-component disinfectant is effective against tuberculosis and/or mycobacterium terreus, and wherein the disinfectant provides a >5 log reduction in contact time of 5 minutes or less. Suitably, the two-component disinfectant composition provides a >5 log reduction at a contact time of 3 minutes.

In another aspect, the present invention provides an additive for a disinfectant composition, the additive comprising: b) at least one aromatic alcohol; c) at least one glycol or glycol ether; d) at least one nonionic and/or anionic surfactant; and e) at least one acid; wherein the additive, when combined with a disinfecting active ingredient, enhances the disinfecting performance of the composition.

Typically, disinfecting actives include, but are not limited to, hydrogen peroxide solutions, alcohols, oxidants, metal salts, halogens, bleaches, phenols, antibiotic creams, pharmaceutical actives, astringents, antihistamines, analgesics, skin cleansing/cleansing agents, antifungal/antibacterial/germicides, or essential oils, natural extracts, or other actives having disinfecting properties, combinations thereof, and the like.

The following examples illustrate but do not limit the invention. All parts and percentages are given by weight unless otherwise indicated.

Example 1 formulation

TABLE 1 formulation

HP: hydrogen peroxide; PA: phosphoric acid; MSA: methane sulfonic acid; C/D glycoside: octanoyl/decyl glycoside; nonionic surfactant: 2-ethylhexanol EO-PO nonionic surfactant; and (3) LAS: linear alkyl benzene sulfonic acid; EDDS: ethylenediamine-N, N' -disuccinic acid (35%); ethoxylated alcohol C_12-14Secondary 70 percent; DGME: diethylene glycol monobutyl ether; TGME: triethylene glycol monobutyl ether.

All of the formulation solutions in table 1 may be present as such (ready for use) or may be concentrated in two basic ways, which are shown in table 7 using formulation 2 as an example. The first way is to simply make a 1:4 concentrate, for example but not limited to, which will be diluted with appropriate amounts of hydrogen peroxide and water.

Formulation 5 in table 1 is an acidified hydrogen peroxide formulation containing surfactant but the composition does not contain blended solvent, which results in low log reduction of mycobacterium terrae (see table 2). Formulation 3 comprised the ingredients of formulation 5 plus a novel solvent blend, which showed a significant increase in the log reduction of mycobacterium terrae. Formulation 4 contained the ingredients of formulation 5 plus only half of the solvent blending divinyl; it showed hardly any log reduction of M.terreus. Formulation 1 included a novel solvent in the formulation at a blend ratio that exhibited a significant increase in the log reduction of mycobacterium terrae. Formulation 2 is similar to formulation 4, but it also contains 1.5% phenoxyethanol, which increases the log reduction of M.terrae. Formulation 6 is similar to formulation 2, but the level of phenoxyethanol and the level of butyl carbitol doubled, which significantly increased the log reduction of M.terrae.

It is important to note that the solvent blends containing glycol ether and phenoxyethanol (formulations 7 and 2) have an increasing effect on the efficacy of mycobacterium terrae and TB. Formulation 2 had even lower levels of solvent blending, but also successfully passed TB, which is even more surprising.

Example 2 Mycobacterium terrae OECD test at 3min contact time

TABLE 2 results of the Mycobacterium terrae OECD test method

Formulation of	Log of Mycobacterium terrae10Reduction of
		1	5.02
2	3.41
		3	3.87
4	0.62
		5	1.20
6	5.02

The AOAC bactericidal spray test tuberculocidal test was used to evaluate TB, which included testing Mycobacterium Bovis (BCG) ATCC35743 that was cultured at 36. + -. 1 ℃ for 21. + -.2 days in 7H11 growth medium. According to the regulatory agency (EPA) guidelines, all formulations passed and no visible growth was observed in any secondary media culture tubes per batch, and the controls met their regulatory standards. When tested as described, all formulations were passed through mycobacterium Bovis (BCG), which contained 5% organic soil load, for 3 minutes of contact. All test controls met the established criteria for effective testing.

However, it is particularly surprising that the solvent blends containing glycol ether and phenoxyethanol (formulations 7 and 2) have a significant impact on increasing the efficacy of mycobacterium terrae and TB. Formulation 2 had even lower levels of solvent blending, but also succeeded in passing TB, which was even more surprising.

Example 3 TB evaluation (pass/fail)

TABLE 3.3 TB evaluation of contact time

Formulation of	Tuberculocidal effectiveness test	Pass/fail
			1	0/30	By passing
2	0/30	By passing
			7	0/30	By passing

Example 4 stability testing

TABLE 4 physical stability testing of disinfectant compositions

Formulations 1, 7 and 2 were filled into lidded 4 oz glass jars and placed in ovens at different controlled temperatures. The samples were pulled at the times and temperatures shown in table 4 and visually evaluated. All samples were found to have acceptable physical stability at the end of week 4.

Example 5 Hydrogen peroxide stability

TABLE 5 Hydrogen peroxide stability

The same formulations tested in Table 4Recipe H at 50 ℃ for 4 weeks₂O₂Stability testing (see table 5). All formulations had reasonably good peroxide stability and were in H at 50 ℃ for 4 weeks₂O₂The decrease in medium is not more than 6 w/w%.

Calculate percent hydrogen peroxide loss: h₂O₂% loss ═ H₂O₂Initial quantity-after-storage H₂O₂Amount of)/H₂O₂Initial amount, multiply the result by 100.

EXAMPLE 6 AOAC germicidal spray method for hard surface Disinfection

TABLE 6 AOAC germicidal spray method for hard surface disinfection

Formulation 2 was tested microscopically for salmonella enterica, staphylococcus aureus and pseudomonas aeruginosa under GLP conditions using the AOAC germicidal spray method for hard surface disinfection using a 5% soil load (bovine fetal serum) and a 1 minute contact time (see table 6). Formulation 2 passed against all 3 organisms under GLP conditions.

Example 7 formulation #2

TABLE 7 formulation #2 comparison (w/w%)

	Solvent bag A	Concentrate A	Concentrate B
				Deionized water	-	44.45	53.90
Phosphoric acid (85%)	-	2.65	5.30
				Methanesulfonic acid (70%)	-	11.45	22.90
Ethylenediamine-N, N' -disuccinic acid (35%)	-	1.45	2.90
				Alcohol, C12-C14Sec, B oxidation (70%)	-	7.5	15.0
Phenoxyethanol	23.1	7.5	-
				Diethylene glycol monobutyl ether	76.9	25	-
Total of	100.00	100.00	100.00

All of the formulation solutions in table 1 may be present as such (ready for use) or may be concentrated in two basic ways, which are shown in table 7 using formulation 2 as an example. The first way is to simply make a 1:4 concentrate, for example but not limited to, which will be diluted with appropriate amounts of hydrogen peroxide and water.

Example 8 formulation #2 concentrate Package formulation

TABLE 8 comparison of concentrate A and B packages

Composition (I)	RTU prepared from concentrate A	RTU prepared from concentrate B and solvent bag
			Deionized water	77.67	81.17
Hydrogen peroxide (50%)	2.33	2.33
			Concentrate A	20.0	-
Concentrate B	-	10.00
			Solvent bag	-	6.50
Total of	100.00	100.00

The second approach is similar to the first, but removes not only hydrogen peroxide from the concentrate, but also both solvents (table 7). The concentrate will therefore be diluted with water, hydrogen peroxide and/or a solvent package containing diethylene glycol monobutyl ether and phenoxyethanol (table 8).

It will be understood that each element of the above-described embodiments, or two or more together, may also find a useful application in other types of methods differing from the types described above. Without further analysis, the foregoing will so fully reveal the gist of the present invention that others can, by applying ordinary knowledge, readily adapt it for various applications without omitting features that, from the standpoint of prior art: which constitute essential characteristics of the generic and specific aspects of the invention as set out in the appended claims, as appropriate from a prior art standpoint.

The foregoing embodiments are presented by way of example only; the scope of the invention is limited only by the following claims.

Although the invention has been described above with reference to specific embodiments thereof, it is evident that many changes, modifications and variations can be made without departing from the inventive concept disclosed herein. Accordingly, it is intended to embrace all such changes, modifications and variations that fall within the spirit and broad scope of the appended claims.