阅读说明：本技术 Ebv表位高亲和力t细胞受体 (EBV epitope high affinity T cell receptors ) 是由 王飞 赵正琦 王石雷 尹悦露 李波 侯勇 于 2018-12-27 设计创作，主要内容包括：本发明公开了一种EBV表位高亲和力T细胞受体。本发明所提供的EBV表位高亲和力T细胞受体包含α链和β链；所述α链包含三个互补决定区,序列分别为SEQ ID No.3的第43-49位、第67-71位以及第106-116位；所述β链包含三个互补决定区,氨基酸序列分别为SEQ ID No.4的第46-50位、第68-73位以及第111-118位。本发明所提供的表达TCR的T细胞可以有效的识别T2细胞负载的EBV抗原多肽,并分泌IFN-γ,证明其具有功能。本发明提供的EBV表位高亲和力T细胞受体具有重要的应用价值。(The invention discloses an EBV epitope high-affinity T cell receptor. The EBV epitope high-affinity T cell receptor provided by the invention comprises an alpha chain and a beta chain; the alpha chain comprises three complementarity determining regions with the sequences of 43-49, 67-71 and 106-116 of SEQ ID No. 3; the beta-strand comprises three complementarity determining regions having amino acid sequences at positions 46-50, 68-73 and 111-118 of SEQ ID No.4, respectively. The T cell expressing the TCR provided by the invention can effectively recognize EBV antigen polypeptide loaded by T2 cells, and secrete IFN-gamma, so that the T cell expressing the TCR has functions. The EBV epitope high-affinity T cell receptor provided by the invention has important application value.)