Antioxidant whitening composition and preparation method thereof
阅读说明：本技术 一种抗氧化美白组合物及其制备方法 (Antioxidant whitening composition and preparation method thereof ) 是由 范亨林 吴骞 于 2021-07-26 设计创作，主要内容包括：本发明属于护肤品技术领域,具体涉及一种抗氧化美白组合物及其制备方法。本发明提供的抗氧化美白组合物,包括如下组分及其重量份数的原料制成：甘草10～16份,白丁香11～15份,人参10～14份,冬虫夏草9～16份,燕窝提取物9～15份,玫瑰1～5份,白芨2～4份,麦冬1～6份。本发明提供的抗氧化美白组合物,采用多种天然的植物提取物复配而得,具有温和安全无刺激等优点,同时配合本发明所采用的独特的制备工艺,使得到的抗氧化美白组合物具有活血淡斑,增白滋养的功效,能够有效抑制黑色素及老年斑的生成。(The invention belongs to the technical field of skin care products, and particularly relates to an antioxidant whitening composition and a preparation method thereof. The invention provides an antioxidant whitening composition which is prepared from the following components in parts by weight: 10-16 parts of liquorice, 11-15 parts of white clove, 10-14 parts of ginseng, 9-16 parts of cordyceps sinensis, 9-15 parts of bird's nest extract, 1-5 parts of rose, 2-4 parts of bletilla striata and 1-6 parts of radix ophiopogonis. The antioxidant whitening composition provided by the invention is prepared by compounding various natural plant extracts, has the advantages of being mild, safe, non-irritant and the like, and has the effects of promoting blood circulation, lightening spots, whitening and nourishing by matching with the unique preparation process adopted by the invention, and can effectively inhibit the generation of melanin and senile spots.)
1. The antioxidant whitening composition is characterized by comprising the following components in parts by weight:
10-16 parts of liquorice, 11-15 parts of white clove, 10-14 parts of ginseng, 9-16 parts of cordyceps sinensis, 9-15 parts of bird's nest extract, 1-5 parts of rose, 2-4 parts of bletilla striata and 1-6 parts of radix ophiopogonis.
2. The antioxidant whitening composition of claim 1, which is prepared from the following raw materials in parts by weight:
14 parts of liquorice, 12 parts of white clove, 12 parts of ginseng, 12 parts of cordyceps sinensis, 12 parts of bird's nest extract, 3 parts of rose, 3 parts of bletilla striata and 3 parts of radix ophiopogonis.
3. A method for preparing the antioxidant whitening composition of claim 1 or 2, comprising the steps of:
s1, cleaning, drying and crushing liquorice, white cloves, ginseng, cordyceps sinensis, roses, bletilla striata and radix ophiopogonis, sieving with a 60-100-mesh sieve, and storing at-18 ℃ for 2-5 hours to obtain pretreated plant powder;
s2, adding a wetting agent with the weight 2-3 times that of the pretreated plant powder obtained in the step S2, uniformly mixing, soaking for 3-5 hours, and performing ultrasonic treatment for 10-20 min to obtain a pretreated plant extract;
s3, adding 3-8 weight parts of extracting solution into the pretreated plant extracting solution obtained in the step S2, uniformly mixing, performing reflux extraction at 50-80 ℃ for 2-3 times for 1-3 hours each time, filtering, and combining the extracting solutions to obtain the plant extracting solution;
s4, adding the cubilose extract and the protective agent into the plant extract obtained in the step S4, and carrying out high-pressure homogenization for 20-30 min to obtain the plant extract.
4. The method for preparing the antioxidant whitening composition of claim 3, wherein the humectant in the step S2 consists of polyvinylpyrrolidone, sapindoside and water in a weight ratio of 1-3: 2-10: 15-30.
5. The method of preparing the antioxidant whitening composition of claim 4, wherein the humectant of step S2 consists of polyvinylpyrrolidone, sapindoside and water in a weight ratio of 2:6: 23.
6. The method for preparing the antioxidant whitening composition of claim 3, wherein the ultrasonic power used in the ultrasonic treatment in the step S2 is 600-1000W, and the ultrasonic frequency is 20-80 kHz.
7. The method for preparing the antioxidant whitening composition of claim 3, wherein the extract of step S3 is composed of 60-90% ethanol solution and n-butanol at a volume ratio of 3-7: 1.
8. The method for preparing the antioxidant whitening composition of claim 3, wherein the addition amount of the protective agent in the step S4 is 0.3-1.8% of the plant extract obtained in the step S3, and the protective agent is composed of glucuronic acid and sodium alginate in a weight ratio of 7 (1-3).
9. The method of preparing the antioxidant whitening composition of claim 3, wherein the homogenization pressure used in the high-pressure homogenization treatment in the step S4 is 20 to 90 MPa.
10. A prepared cosmetic containing the antioxidant whitening composition as claimed in any one of claims 1 to 9 and an auxiliary material, wherein the cosmetic is one or more of cream, lotion, aqua, essence, mask and facial cleanser; the auxiliary materials are one or more of emulsifier, thickener, grease, solvent, surfactant, skin conditioner, essence and preservative.
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to an antioxidant whitening composition and a preparation method thereof.
Background
With the development of society and the improvement of living standard of people, the requirement of consumers on beauty is higher and higher, and the requirement on the efficacy of products is more and more definite. Because Asia mainly takes the yellow race, the female has the problems of dark skin color, dark yellow, lack of luster, easy allergy, pigmentation and the like. The melanin production of the skin is caused by various factors, such as genetic factors and environmental factors, and the production causes are quite complicated. The current research results basically consider that the reason is that: tyrosine in skin cells generates dopa and dopaquinone under the action of tyrosinase, and the dopaquinone is polymerized into Indole-5.6-quinone through a series of metabolic reactions to finally form melanin.
Most of the existing whitening and freckle-removing products on the market are unstable in quality, unobvious in effect or high in irritation. The whitening and freckle-removing raw materials are numerous but have various advantages and disadvantages, and the traditional whitening agent has the disadvantages of different degrees. For example, the dihydroxybenzene and the kojic acid are whitening prohibited articles in Europe, America or Japan respectively, and are characterized by high toxicity and unstable hydrolysis; arbutin and arbutin are glucoside of hydroquinone, have the problems of toxicity similar to hydroquinone, unstable hydrolysis, increase of melanin of skin when the using amount is large, and the like.
Natural plants have many active ingredients, such as organic acids, saponins, alkaloids, flavonoids and other active ingredients in plants, and have different efficacies, generally, the plant beauty safety is higher, and the raw materials are from nature, are more environment-friendly, healthy and safe, so that the natural plants are increasingly paid attention to. For example, chinese patent CN 105434239B discloses the use of a skin whitening composition containing natural plant sources in cosmetics, which contains rhodiola rosea extract and mulberry leaf extract as whitening active components. Chinese patent application CN106726984A discloses a cosmetic composition with whitening and acne removing effects and application thereof, wherein sanguisorba officinalis extract, sophora flavescens root extract, mint leaf extract and licorice root extract are compounded in whitening and acne removing emulsion according to a specific proportion, so that the whitening and acne removing emulsion can promote skin blood vessel microcirculation, clear away heat and toxic materials, activate blood stasis and remove free radicals. However, the active ingredients of natural plants are complex, improper extraction method can not only cause the situations of insufficient utilization, resource waste and the like, but also the obtained composition has poor stability, and can cause skin pore blockage, hair follicle inflammation, skin problems of large pore, blackhead and the like.
Therefore, there is an urgent need to develop an antioxidant whitening composition extracted from natural plants, which has good safety and stability and has a significant melanin inhibiting effect.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide an antioxidant whitening composition and a preparation method thereof. The antioxidant whitening composition provided by the invention is prepared by compounding various natural plant extracts, has the advantages of being mild, safe, non-irritant and the like, and simultaneously has the effects of activating blood circulation, lightening spots, whitening and nourishing by matching with the unique preparation process adopted by the invention, and can effectively inhibit the generation of melanin and senile spots.
The technical scheme of the invention is as follows:
an antioxidant whitening composition comprises the following components in parts by weight:
10-16 parts of liquorice, 11-15 parts of white clove, 10-14 parts of ginseng, 9-16 parts of cordyceps sinensis, 9-15 parts of bird's nest extract, 1-5 parts of rose, 2-4 parts of bletilla striata and 1-6 parts of radix ophiopogonis.
Further, the antioxidant whitening composition is prepared from the following raw materials in parts by weight:
14 parts of liquorice, 12 parts of white clove, 12 parts of ginseng, 12 parts of cordyceps sinensis, 12 parts of bird's nest extract, 3 parts of rose, 3 parts of bletilla striata and 3 parts of radix ophiopogonis.
The main plants and extracts used in the present invention have the following effects:
licorice root: spleen invigorating qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, and relieving spasm and pain. The flavone component contained in Glycyrrhrizae radix can inhibit tyrosinase activity, reduce melanin generation, and regulate and relieve skin.
White clove: clearing heat, dispelling pathogenic wind, removing speckle, caring skin, improving complexion, promoting blood circulation, removing blood stasis, promoting metabolism, activating skin cells, whitening skin, and removing speckle.
Ginseng: tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote the production of body fluid to quench thirst. Can regulate brain central nerve, promote energy utilization of brain, improve heart function, resist oxidation, scavenge free radicals, promote blood circulation, improve cell metabolism, and delay skin aging.
And (3) cordyceps sinensis: promoting metabolism, scavenging free radicals, and enhancing immunity. The cordyceps sinensis contains active ingredients such as polysaccharide, amino acid, polypeptide (protein), nucleic acid, vitamin and the like, and can relieve the decrease of central catecholamine level caused by aging and the damage to the biochemical process of an organism caused by the decrease of the central catecholamine level, thereby playing the roles of delaying aging and keeping healthy and long life.
The cubilose extract: the edible bird's nest has the effects of nourishing yin, moistening dryness, tonifying qi, strengthening middle warmer, maintaining beauty, keeping young, relaxing skin, promoting skin metabolism, supplementing collagen, quickly repairing damaged skin, astringing oil and refining pores, contains a large amount of protein, sialic acid, trace elements and other bioactive components, has the effects of nourishing, moisturizing and whitening, contains epidermal growth factors for promoting cell differentiation, has the effect of promoting cell division, and can quickly repair skin. Sialic acid can inhibit tyrosinase, thereby preventing melanin and whitening skin.
And (3) rose: promoting qi circulation, relieving depression, nourishing blood, dispelling blood stasis, caring skin.
Bletilla striata: astringe to stop bleeding, resolve swelling and promote tissue regeneration.
Radix ophiopogonis: nourishing yin, promoting fluid production, moistening skin, relieving inflammation, enhancing immunity, and resisting allergy.
The invention also provides a preparation method of the antioxidant whitening composition, which comprises the following preparation steps:
s1, cleaning, drying and crushing liquorice, white cloves, ginseng, cordyceps sinensis, roses, bletilla striata and radix ophiopogonis, sieving with a 60-100-mesh sieve, and storing at-18 ℃ for 2-5 hours to obtain pretreated plant powder;
s2, adding a wetting agent with the weight 2-3 times that of the pretreated plant powder obtained in the step S2, uniformly mixing, soaking for 3-5 hours, and performing ultrasonic treatment for 10-20 min to obtain a pretreated plant extract;
s3, adding 3-8 weight parts of extracting solution into the pretreated plant extracting solution obtained in the step S2, uniformly mixing, performing reflux extraction at 50-80 ℃ for 2-3 times for 1-3 hours each time, filtering, and combining the extracting solutions to obtain the plant extracting solution;
s4, adding the cubilose extract and the protective agent into the plant extract obtained in the step S4, and carrying out high-pressure homogenization for 20-30 min to obtain the plant extract.
Further, the wetting agent in the step S2 is composed of polyvinylpyrrolidone, sapindoside and water in a weight ratio of 1-3: 2-10: 15-30.
Further, the wetting agent in the step S2 is composed of polyvinylpyrrolidone, sapindoside and water in a weight ratio of 2:6: 23.
Further, the ultrasonic power used in the ultrasonic treatment in the step S2 is 600 to 1000W, and the ultrasonic frequency is 20 to 80 kHz.
Further, the extracting solution in the step S3 is composed of 60-90% of ethanol solution and n-butyl alcohol according to the volume ratio of 3-7: 1.
Further, the extraction solution in the step S3 is composed of a 75% ethanol solution and n-butanol at a volume ratio of 5: 1.
Furthermore, the addition amount of the protective agent in the step S4 is 0.3-1.8% of the plant extract obtained in the step S3, and the protective agent consists of glucuronic acid and sodium alginate in a weight ratio of 7 (1-3).
Further, the addition amount of the protective agent in the step S4 is 1.2% of the plant extract obtained in the step S3, and the protective agent is composed of glucuronic acid and sodium alginate in a weight ratio of 7: 2.
Further, the homogenization pressure used in the step S4 is 20 to 90Mpa when the high-pressure homogenization treatment is performed.
In addition, the invention also provides a cosmetic prepared from the antioxidant whitening composition and auxiliary materials, wherein the cosmetic is one or more of cream, lotion, aqua, essence, mask and facial cleanser; the auxiliary materials are one or more of emulsifier, thickener, grease, solvent, surfactant, skin conditioner, essence and preservative.
In the antioxidant whitening composition provided by the application, effective components in liquorice, lilac, ginseng, cordyceps sinensis, roses, bletilla striata and radix ophiopogonis are extracted, and the obtained plant extract and the cubilose extract mutually generate a synergistic effect according to different proportions, so that the metabolism of cells can be effectively promoted, the generation of melanin in the cells can be effectively inhibited, and the whitening and spot-lightening effects are achieved.
Meanwhile, in order to better extract effective components in various natural plants, the inventor of the application adopts various treatment means to pretreat plant components, and firstly adopts the steps of crushing, drying, freezing and the like, so that the pretreated plant powder can be more dispersed and is not easy to agglomerate; then, the wetting agent composed of polyvinylpyrrolidone and sapindoside according to a certain proportion is adopted to soak the pretreated plant powder, so that the surface tension of the plant powder can be effectively reduced, the wetting property of a solid-liquid system is improved, meanwhile, the wetting agent is adsorbed on the surface of the plant powder to form an adsorption layer in directional arrangement, and the free energy of the interfacial energy can be effectively reduced, thereby effectively changing the wetting property of the surface of the plant powder, leading water to better wet solids, accelerating the dissolution of effective components in the medicine, and effectively improving the whitening and antioxidation effects of the composition. And then, extracting the plant extract by adopting an organic solvent, and finally, carrying out high-pressure homogenization treatment on the extract, the cubilose extract and a protective agent consisting of glucuronic acid and sodium alginate, so that the uniformity and stability of the composition are further improved, and the phenomena of layering precipitation and the like of the composition are prevented, thereby jointly achieving the optimal effects of resisting oxidation and inhibiting melanin. Experiments prove that the antioxidant whitening composition prepared by the invention has excellent effects on inhibiting melanin generation and removing DPPH free radicals, the melanin content of the wild zebra fish in the group of the embodiment 2 is only 0.34 +/-0.01, the melanin content is reduced (66 +/-10%) compared with that of a normal control group, and the DPPH free radical removal rate is 81.21%, so that the composition can be applied to skin care products, can effectively adjust the internal environment of facial skin, and can remove facial pigments, thereby achieving the whitening effect.
Compared with the prior art, the antioxidant whitening composition provided by the invention has the following advantages:
(1) the antioxidant whitening composition provided by the invention extracts effective components in liquorice, lilac, ginseng, cordyceps sinensis, rose, bletilla striata and radix ophiopogonis, and the obtained plant extract and the cubilose extract generate a synergistic effect mutually according to different proportions, so that the metabolism of cells can be effectively promoted, the generation of melanin in the cells can be effectively inhibited, and the whitening and spot-lightening effects are achieved.
(2) The antioxidant whitening composition provided by the invention adopts a specific preparation process, and the prepared composition can mobilize the self-repairing capacity of skin, improve the cell metabolism function and improve the free radical cleaning capacity.
(3) The antioxidant whitening composition provided by the invention adopts natural plant extract components, is safe and mild, does not stimulate, can be used for preparing antioxidant and whitening skin care products, and fundamentally solves the problem of color spots.
Detailed Description
The present invention is further illustrated by the following description of specific embodiments, which are not intended to limit the invention, and various modifications and improvements can be made by those skilled in the art based on the basic idea of the invention, but the invention is within the protection scope of the invention.
Nidus Collocaliae extract, purchased from Sian Baichuan Biotech limited; sapindus saponin, purchased from Saian Tianbao Biotech limited; polyvinylpyrrolidone (molecular weight 40000) was purchased from shanghai source, leaf biotechnology limited, cat #: s30268-100 g.
In addition, other reagents used in the invention are common reagents and can be purchased from conventional reagent production and sale companies.
Examples 1 to 3 antioxidant whitening composition of the present invention and method for preparing the same
Table 1 weight ratio table of 3 examples of the present invention
Component (in kg)
Example 1
Example 2
Example 3
Licorice root, radix Glycyrrhizae
10
14
16
White clove
11
12
15
Ginseng radix
10
12
14
Chinese Caterpillar fungus
9
12
16
Bird's nest extract
9
12
15
Rose
1
3
5
Rhizoma bletilla
2
3
4
Ophiopogon japonicus
1
3
6
Table 2 materials and ratios added in the preparation process of 3 embodiments of the present invention
The preparation method of the antioxidant whitening composition of examples 1 to 3 is as follows:
s1, cleaning radix Glycyrrhizae, flos Caryophylli, radix Ginseng, Cordyceps, flos Rosae Rugosae, rhizoma Bletillae, and radix Ophiopogonis, drying, pulverizing, sieving with 80 mesh sieve, and storing at-18 deg.C for 3 hr to obtain pretreated plant powder;
s2, adding a wetting agent with the weight 3 times that of the pretreated plant powder obtained in the step S2, uniformly mixing, soaking for 4 hours, and performing ultrasonic treatment for 15 minutes at the ultrasonic power of 800W and the ultrasonic frequency of 60kHz to obtain a pretreated plant extracting solution;
s3, adding 3-8 weight parts of extracting solution into the pretreated plant extracting solution obtained in the step S2, uniformly mixing, performing reflux extraction at 70 ℃ for 2 times, 2 hours each time, filtering, and combining the extracting solutions to obtain the plant extracting solution;
s4, adding the cubilose extract and a protective agent into the plant extract obtained in the step S4, and carrying out high-pressure homogenization treatment for 25min, wherein the homogenization pressure is 70 Mpa.
Comparative examples 1-4 antioxidant whitening composition and preparation method thereof
TABLE 3 weight ratio table of each component of comparative examples 1 to 4 of the present invention
The preparation method of the antioxidant whitening composition in comparative examples 1 to 4 is similar to that of example 2, and is different from that of example 2 in the component content, which is specifically shown in table 2.
Comparative example 5 an antioxidant whitening composition and a method for preparing the same
Comparative example 5 is different from example 2 in that the pre-treated plant powder was not stored at-18 c in the step S1, and other parameters and operation are the same as example 2.
Comparative example 6 an antioxidant whitening composition and a method for preparing the same
In comparison with example 2, comparative example 6 is different in that sapindoside is not added to the humectant in step S1, and other parameters and operations are the same as example 2.
Comparative example 7 an antioxidant whitening composition and a method for preparing the same
Comparative example 7 is different from example 2 in that the extract liquid in step S3 consists of a 75% ethanol solution and n-butanol in a volume ratio of 1:1, and other parameters and operations are the same as example 2.
Comparative example 8 an antioxidant whitening composition and a method for preparing the same
Compared with example 2, comparative example 8 is different in that the protecting agent in step S4 is composed of glucuronic acid and sodium alginate in a weight ratio of 1:1, and other parameters and operations are the same as example 2.
Comparative example 9 an antioxidant whitening composition and a method for preparing the same
In comparison with example 2, comparative example 9 is different in that glucuronic acid in the protecting agent in the step S4 is replaced with ascorbic acid, and other parameters and operations are the same as example 2.
Comparative example 10 an antioxidant whitening composition and a method for preparing the same
In comparison with example 2, comparative example 10 is different in that the high-pressure homogenization treatment was not performed in step S4, and other parameters and operations are the same as those of example 2.
Test example I test for inhibiting melanin
1. Test materials: the antioxidant whitening compositions prepared in examples 1 to 3 and comparative examples 1 to 10.
2. Test subjects: line AB wild type zebrafish 24hpf embryos.
3. The test method comprises the following steps: the antioxidant whitening compositions prepared in examples 1-3 and comparative examples 1-10 were diluted to 1% of the test sample, and AB series wild type zebrafish 24hpf embryos were tested, 20 in each group, and 3 groups were repeated. Except for the normal control group, the blood vessel regeneration inhibitor is used for molding to construct a zebra fish microcirculation injury model. And (3) observing the development state of the embryo in the third day, selecting representative 2-3 tails for fluorescence microscopic imaging in each group, counting the areas of pigment plaques in a fluorescence imaging image of the microscope, and processing data. The experiment was committed to the institute of biomedical sciences of Guangdong university of Industrial science.
4. Test results
The test results are shown in table 4.
TABLE 4 melanin content (mean. + -. SE)
As can be seen from table 4, the melanin contents of the groups of examples 1 to 3 are significantly reduced compared to the normal control group, wherein the group of example 2 has the best effect, and the reduction of the melanin contents (66 ± 10%) compared to the normal control group is the best embodiment of the present invention. In contrast, the melanin contents of comparative examples 1 to 10 were reduced compared to the examples, but the overall effect was inferior to the examples.
Test example two antioxidant DPPH radical scavenging test
1. Test materials: the antioxidant whitening compositions prepared in examples 1 to 3 and comparative examples 1 to 10.
2. The test method comprises the following steps: 4mL of the solution was added at a concentration of 6X 10-5Adding the mol/L DPPH solution into 4mL of the antioxidant whitening composition prepared in the examples 1-3 and the comparative examples 1-10 respectively, fully and uniformly mixing, and immediately obtaining an absorbance value A at 518nmiThen standing the mixture for 30 minutes in a dark place at room temperature, and measuring the absorbance value which is recorded as AjFinally, the absorbance of the solution with DPPH added only was determined and recorded as AcThe DPPH radical clearance is calculated according to the following formula: clearance rate ═ 1- (A)i-Aj)/Ac]×100％。
4. Test results
The test results are shown in table 5.
TABLE 5 DPPH radical scavenging Rate
Group of
DPPH radical scavenging ratio (%)
EXAMPLE 1 group
79.36
EXAMPLE 2 group
81.21
EXAMPLE 3 group
80.14
Comparative example 1 group
45.18
Comparative example 2 group
44.16
Comparative example 3 group
48.38
Comparative example 4 group
46.27
Comparative example 5 group
69.14
Comparative example 6 group
49.18
Comparative example 7 group
47.26
Comparative example 8 group
66.18
Comparative example 9 group
65.39
Comparative example 10 group
71.15
As can be seen from Table 5, the DPPH radical scavenging ability of the groups of examples 1 to 3 is strong, and the effect of the group of example 2 is the best, and the DPPH radical scavenging rate is 81.21%, which is the best example of the present invention. Compared with the examples, the DPPH free radical clearance rate of the comparative examples 1 to 10 is obviously reduced compared with the examples 1 to 3.
Test example III stability test
1. Test materials: the antioxidant whitening composition prepared in example 2 and comparative examples 5 to 10.
2. The test method comprises the following steps: the antioxidant whitening compositions prepared in the example 2 and the comparative examples 5-10 are respectively placed in a thermostat for 24 hours, the treatment temperature is 40 ℃ and-2 ℃, the compositions are taken out, the temperature is recovered to the room temperature, and the stability of the compositions is observed.
3. Test results
The test results are shown in table 6.
Table 6 stability test results
Group of
Heat stability (40 ℃ C.)
Cold resistance stability (-2 ℃ C.)
EXAMPLE 2 group
Without change
Without change
Comparative example 5 group
No demixing, little precipitation and smell
No demixing and little precipitation
Comparative example 6 group
No demixing and little precipitation
No demixing and little precipitation
Comparative example 7 group
No demixing and little precipitation
No demixing and little precipitation
Comparative example 8 group
The solution was stratified with obvious precipitation
No demixing and little precipitation
Comparative example 9 group
The solution was stratified with obvious precipitation
No demixing and little precipitation
Comparative example 10 group
The solution was stratified with obvious precipitation
No demixing and little precipitation
As can be seen from Table 6, after the antioxidant whitening composition prepared in example 2 of the invention is treated at 40 ℃ and-2 ℃ for 24 hours, the solution is unchanged, and the phenomena of demixing, turbidity, precipitation and the like do not occur. In comparison examples 5-10, the solutions showed different degrees of delamination and precipitation under the same experimental conditions.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.