阅读说明：本技术 一种含有氟啶虫酰胺的卫生杀虫组合物及其应用 (Sanitary insecticidal composition containing flonicamid and application thereof ) 是由 黄昌建 郭丽琴 于 2020-06-23 设计创作，主要内容包括：本发明涉及一种卫生杀虫组合物及其应用,所述组合物包含活性组分A和活性组分B,活性组分A选自氟啶虫酰胺,活性组分B选自双硫磷、倍硫磷、甲基嘧啶磷。本发明通过活性组分之间的协同增效作用,提高所述组合物的药效及药效稳定性,非常适合室内外卫生害虫蚊蝇防治,且对环境友好,符合未来社会绿色环保的潮流。(The invention relates to a sanitary insecticidal composition and application thereof, wherein the composition comprises an active component A and an active component B, the active component A is selected from flonicamid, and the active component B is selected from parathion, fenthion and pirimiphos-methyl. The composition improves the pesticide effect and pesticide effect stability of the composition through the synergistic interaction between the active components, is very suitable for preventing and controlling indoor and outdoor sanitary pests such as mosquitoes and flies, is environment-friendly, and accords with the trend of green and environment protection of future society.)

1. A sanitary insecticidal composition characterized by: the composition comprises an active component A and an active component B, wherein the active component A is selected from flonicamid, the active component B is selected from any one of parathion, fenthion and pirimiphos-methyl, and the weight ratio of the parathion to the pirimiphos-methyl is 80: 1-1: 80.

2. The insecticidal composition according to claim 1, wherein the weight ratio of the two is 1:20 to 20: 1.

3. The insecticidal composition according to claim 2, wherein the weight ratio of the two is 1:5 to 5: 1.

4. An insecticidal formulation comprising an insecticidal composition according to any one of claims 1 to 3 and a pesticidally acceptable adjuvant, wherein the insecticidal composition comprises from 0.01 to 90% by weight of the formulation.

5. A sanitary insecticide composition as claimed in any one of claims 1 to 4, wherein said sanitary insecticide composition is in the form of emulsifiable concentrate, microemulsion, suspoemulsion, granules, and the active ingredient is present in the formulation in an amount of 1 to 50% by weight.

6. The use of the sanitary pesticidal composition according to any one of claims 1 to 5 for controlling sanitary pests, wherein the sanitary pests are diptera-botanic pests, wigglers, fly larvae.

Technical Field

The invention relates to the field of sanitary insecticides, in particular to a sanitary insecticidal composition containing flonicamid and application thereof.

Background

The flonicamid is a novel low-toxicity pyridine amide insect growth regulator insecticide developed by Japan Stone original products K company (ISK), has a molecular formula of C9H6F3N3, has good contact poisoning and stomach poisoning effects, also has good nerve toxin and quick antifeedant effects, mainly acts on cotton, fruits, cucurbits, vegetables, potatoes and pomes, and can effectively control aphids, whiteflies, thrips, bed bugs and the like at a lower dose. The insecticidal composition has unique action mechanism, has good nerve action and quick antifeedant activity on piercing-sucking pests, has no mutual antagonism with other active components, has lower sensitivity and has no antagonism with the traditional insecticide.

The disulfoton is low-toxicity organophosphorus pesticide, and the rat acute oral LD₅₀: 860 mg/kg (male), 13000 mg/kg (female), acute transdermalLD₅₀>4000 mg/kg. The parathion is mainly used for contact killing, has no systemic property and broad-spectrum insecticidal action, and can be used for public health to prevent and control wigglers, chironomids, moths and mothmididae larvae; can also prevent and treat lice on human body, and flea lice on dogs and cats; can also be used for controlling cutworm, thrips on citrus and lygus on pasture.

Fenthion, also known as butcher, bayten, baycin, O, O-dimethyl-O- (3-methyl-4-methylthiophenyl) thiophosphate is an organophosphorus insecticide with contact poisoning, stomach toxicity, broad spectrum, quick action, long lasting period and low toxicity to human and livestock. The insecticidal composition is mainly used for preventing and treating soybean pod borers, cotton, fruit trees, vegetables and rice pests, and also can be used for preventing and treating sanitary pests such as mosquitoes, flies, bed bugs, lice, cockroaches and the like.

The pirimiphos-methyl is an organophosphorus quick-acting broad-spectrum insecticide and acaricide, and has stomach toxicity and fumigation effects. Has good drug effect on stored grain beetles, weevils, rice weevils, flour weevils, grain silverfish, pink webworm, moths and mites. Can also be used for preventing and treating pests in warehouses, families and public health (mosquitoes and flies).

The inventor carries out deep research on the compounding of flonicamid and fenthion, disulfoton or pirimiphos-methyl, finds that the combination of flonicamid and fenthion, disulfoton or pirimiphos-methyl shows obvious synergistic effect on mosquito and fly larvae in a certain compounding proportion range on the basis of a large number of indoor formula screening tests and outdoor pesticide effect tests, is particularly suitable for the mosquito and fly larvae with drug resistance to conventional pyrethroid single or compound agents, organophosphorus and carbamate pesticides, and can realize double benefits in the aspects of economy and mammal safety.

The compound composition has the characteristics of high efficiency, low toxicity and low irritation, is very suitable for indoor and outdoor sanitary pest control, and is greatly improved in the aspects of high efficiency, low toxicity, quick effect and resistance control compared with the existing sanitary insecticidal composition.

Disclosure of Invention

The invention aims to solve the defects of single application of pesticide, and provides an insecticidal compound preparation containing flonicamid, parathion, fenthion or pirimiphos-methyl, which has the advantages of high efficiency, low toxicity, low cost, good quick-acting property and long lasting period, and is beneficial to the comprehensive treatment of pests.

In order to realize the purpose of the invention, the technical scheme of the invention is as follows:

the sanitary insecticidal composition containing flonicamid is characterized by comprising an active component A and an active component B, wherein the active component A is selected from flonicamid, and the active component B is selected from any one of fenthion, disulfoton or pirimiphos-methyl, and the weight ratio of the two is 80: 1-1: 80.

Preferably, in the sanitary insecticidal composition, the weight ratio of flonicamid to fenthion, parathion or pirimiphos-methyl is 1: 20-20: 1; more preferably, the weight ratio of the two is 1: 5-5: 1.

Furthermore, the formulation of the sanitary insecticidal composition is missible oil, microemulsion, suspension emulsion and granules. In the preparation, the dosage of the active ingredients is 1-50 wt%; preferred are emulsifiable concentrates and granules.

Further, the present invention also provides the use of the above sanitary insecticidal composition for controlling sanitary pests, wherein the sanitary pests are wigglers and fly maggots.

Compared with the prior art, the invention has the beneficial effects that:

(1) compared with a single agent, the insecticidal composition has obvious synergistic effect on pests, and the synergistic coefficients are all over 130 and even over 200.

(2) The sanitary insecticidal composition has a brand-new action mechanism, and is particularly suitable for preventing and controlling sanitary pests with resistance to pyrethroids, organophosphorus and carbamates.

(3) The flonicamid has strong systemic activity and long-lasting effect, and is safe to non-target organisms; fenthion, disulfoton and pirimiphos-methyl have strong contact activity, quick action and little environmental residue; the two are compounded for controlling wigglers or fly maggots, and on the premise of ensuring quick acting and long acting, the composition is environment-friendly and safe for non-target organisms.

(4) The novel compound composition is added to the field of domestic sanitary pesticides, has obvious pesticide effect and can be widely popularized and applied.

Detailed Description

The present invention is further illustrated by the following examples, which are not intended to limit the invention to these embodiments. It will be appreciated by those skilled in the art that the present invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.

First, preparation example

All formulations are referred to as "%" in the following formulations.

Formulation examples 1 to 9:

according to the compounding proportion and the dosage of flonicamid and pirimiphos-methyl in the table-1, auxiliary materials comprise 30g of dimethyl sulfoxide, 5g of calcium dodecyl benzene sulfonate, 10g of castor oil polyoxyethylene ether and methyl oleate, and the balance is added to prepare missible oil preparation examples 1-9.

TABLE-1 formulations examples 1 to 9

Example numbering	Flonicamid	Pirimiphos-methyl	Compounding ratio
				Formulation example 1	0.1g	9.9g	1:99
Formulation example 2	0.1g	8.0g	1:80
				Formulation example 3	0.5g	10g	1:20
Formulation example 4	2.0g	10g	1:5
				Formulation example 5	5.0g	5.0g	1:1
Formulation example 6	10g	2.0g	5:1
				Formulation example 7	10g	0.5g	20:1
Formulation example 8	8.0g	0.1g	80:1
				Formulation example 9	9.9g	0.1g	99:1

Formulation example 10:

the microemulsion preparation example 10 is prepared by adding 4.0g of flonicamid, 6.0g of pirimiphos-methyl, 5.0g of calcium dodecylbenzenesulfonate, 15.0g of block polyether emulsifier, 25.0g of cyclohexanone and water to 100 g.

Formulation example 11:

dissolving 2.0g of calcium dodecyl benzene sulfonate, 2.5g of castor oil polyoxyethylene ether and 2.5g of triphenethyl phenol polyoxyethylene ether phosphate triethanolamine salt in 12g of pirimiphos-methyl, adding water to 50g, and shearing to obtain an aqueous emulsion phase; adding water to 50g of triphenylethylphenol polyoxyethylene ether phosphate triethanolamine salt 3.0g, fatty alcohol polyoxyethylene ether 0.5g, flonicamid 8.0g, xanthan gum 0.3g, ethylene glycol 5.0g and potassium sorbate 0.5g, mixing and grinding to obtain a suspending agent phase; mixing the two solutions to obtain suspension emulsion preparation example 11.

Formulation example 12:

dissolving 1.0g of flonicamid in 2.0g of diisopropyl adipate, adding an emulsifier (0.1 g of calcium dodecyl benzene sulfonate and 0.4g of ethylene oxide propylene oxide block copolymer) for stirring uniformly, dispersing with a proper amount of water containing 1.0g of phenethyl phenol polyoxyethylene ether phosphate triethanolamine salt serving as a dispersing agent, carrying out full rolling adsorption on the liquid in a roller granulator for 30min by using a proper amount of corncob particles, then adding a diluent containing 2.0g of styrene/acrylamide/butyl acrylate copolymer, carrying out full rolling coating for 30min, and drying to obtain slow-release type core particles for later use;

dissolving 1.5g of pirimiphos-methyl in 2.0g of tributyl phosphate, adding an emulsifier (0.2 g of calcium dodecyl benzene sulfonate and 0.8g of castor oil polyoxyethylene ether) for stirring uniformly, uniformly mixing with 0.2g of lignosulfonate dispersant dissolved in a proper amount of water, adsorbing with 2.0g of white carbon black, uniformly mixing with a diluent containing 0.2g of Arabic gum, fully rolling and coating the mixture with the slow-release type core particles in a roller granulator for 30min, and drying to obtain the flonicamid-methyl pirimiphos-methyl granule preparation example 12.

Formulation example 13:

8g of flonicamid, 12g of fenthion, 25g of dimethylacetamide as an auxiliary material, 5g of calcium dodecylbenzene sulfonate, 7g of triphenylethylphenol polyoxyethylene ether phosphate triethanolamine salt and methyl oleate are complemented to prepare emulsifiable solution comparative example 13.

Formulation example 14:

3.0g of flonicamid, 9.0g of fenthion, 4.0g of calcium dodecyl benzene sulfonate, 8.0g of block polyether emulsifier, 13g of castor oil polyoxyethylene ether, 25.0g of sec-butyl alcohol and water are made up to 100g to prepare the microemulsion preparation example 14.

Formulation example 15:

dissolving 3.0g of octylphenol polyoxyethylene ether, 2.5g of block polyether and 2.5g of tristyrylphenol polyoxyethylene ether phosphate triethanolamine salt in 10g of fenthion, adding water to 50g, and shearing to obtain an aqueous emulsion phase; adding water to 50g of triphenylethylphenol polyoxyethylene ether phosphate triethanolamine salt 3.0g, fatty alcohol polyoxyethylene ether 0.5g, flonicamid 15.0g, xanthan gum 0.3g, ethylene glycol 5.0g and potassium sorbate 0.5g, mixing and grinding to obtain a suspending agent phase; mixing the two solutions to obtain suspension emulsion preparation example 15.

Formulation example 16:

dissolving 1.0g of flonicamid in 2.0g of diisopropyl adipate, adding an emulsifier (0.1 g of calcium dodecyl benzene sulfonate and 0.4g of ethylene oxide propylene oxide block copolymer) for stirring uniformly, dispersing with a proper amount of water containing 1.0g of phenethyl phenol polyoxyethylene ether phosphate triethanolamine salt serving as a dispersing agent, carrying out full rolling adsorption on the liquid in a roller granulator for 30min by using a proper amount of corncob particles, then adding a diluent containing 2.0g of styrene/acrylamide/butyl acrylate copolymer, carrying out full rolling coating for 30min, and drying to obtain slow-release type core particles for later use;

dissolving 1.0g of fenthion in 1.0g of tributyl phosphate, adding an emulsifier (0.2 g of calcium dodecyl benzene sulfonate and 0.8g of castor oil polyoxyethylene ether) for stirring uniformly, mixing uniformly with 0.2g of lignosulfonate dispersant dissolved in a proper amount of water, adsorbing by using 2.0g of white carbon black, mixing uniformly with a diluent containing 0.2g of Arabic gum, fully rolling and coating the mixture with the slow-release type core particles in a roller granulator for 30min, and drying to obtain the flonicamid-fenthion granule preparation example 16.

Formulation example 17:

6g of flonicamid, 10g of disulfur, 25g of dimethylacetamide as an auxiliary material, 5g of calcium dodecylbenzene sulfonate, 7g of triphenylethylphenol polyoxyethylene ether phosphate triethanolamine salt and methyl oleate are complemented to prepare the emulsifiable concentrate of comparative example 17.

Formulation example 18:

the microemulsion preparation of example 18 was prepared by adding 4.0g of flonicamid, 12.0g of disulfur, 4.0g of calcium dodecylbenzenesulfonate, 8.0g of block polyether emulsifier, 13g of castor oil polyoxyethylene ether, 25.0g of sec-butanol, and water to 100 g.

Formulation example 19:

dissolving 3.0g of octylphenol polyoxyethylene ether, 2.5g of block polyether and 2.5g of tristyrylphenol polyoxyethylene ether phosphate triethanolamine salt in 12g of parathion, adding water to 50g, and shearing to obtain an aqueous emulsion phase; adding water to 50g of triphenylethylphenol polyoxyethylene ether phosphate triethanolamine salt 3.0g, fatty alcohol polyoxyethylene ether 0.5g, flonicamid 15.0g, xanthan gum 0.3g, ethylene glycol 5.0g and potassium sorbate 0.5g, mixing and grinding to obtain a suspending agent phase; mixing the two solutions to obtain suspension emulsion preparation example 19.

Formulation example 20:

dissolving 1.5g of flonicamid in 2.0g of diisopropyl adipate, adding an emulsifier (0.1 g of calcium dodecyl benzene sulfonate and 0.4g of ethylene oxide propylene oxide block copolymer) for stirring uniformly, dispersing with a proper amount of water containing 1.0g of phenethyl phenol polyoxyethylene ether phosphate triethanolamine salt serving as a dispersing agent, carrying out full rolling adsorption on the liquid in a roller granulator for 30min by using a proper amount of corncob particles, then adding a diluent containing 2.0g of styrene/acrylamide/butyl acrylate copolymer, carrying out full rolling coating for 30min, and drying to obtain slow-release type core particles for later use;

dissolving 2.0g of parathion in 1.0g of tributyl phosphate, adding an emulsifier (0.2 g of calcium dodecyl benzene sulfonate and 0.8g of castor oil polyoxyethylene ether) for stirring uniformly, uniformly mixing with 0.2g of lignosulfonate dispersant dissolved in a proper amount of water, adsorbing with 2.0g of white carbon black, uniformly mixing with a diluent containing 0.2g of Arabic gum, fully rolling and coating with the slow-release core particles in a roller granulator for 30min, and drying to obtain the flonicamid-parathion granule preparation in the embodiment 20.

Comparative example 1:

10g of flonicamid, 30g of dimethyl sulfoxide as an auxiliary material, 5g of calcium dodecyl benzene sulfonate, 10g of castor oil polyoxyethylene ether and methyl oleate are complemented to prepare the emulsifiable solution of comparative example 1.

Comparative example 2:

10g of pirimiphos-methyl, 30g of dimethyl sulfoxide as an auxiliary material, 5g of calcium dodecyl benzene sulfonate, 10g of castor oil polyoxyethylene ether and methyl oleate in balance to prepare the missible oil comparative example 2.

Comparative example 3:

10g of fenthion, 30g of dimethyl sulfoxide as an auxiliary material, 5g of calcium dodecyl benzene sulfonate, 10g of castor oil polyoxyethylene ether and methyl oleate are complemented to prepare the missible oil comparative example 3.

Comparative example 4:

10g of parathion, 30g of dimethyl sulfoxide as auxiliary materials, 5g of calcium dodecyl benzene sulfonate, 10g of castor oil polyoxyethylene ether and methyl oleate are complemented to prepare missible oil comparative example 3.

II, application embodiment:

application example 1: indoor efficacy test for preventing and treating culex pipiens pallens larvae

The test method comprises the following steps:

adding 3L of dechlorinated tap water into a white porcelain basin, sucking 1ml of prepared liquid medicine, dripping into water, stirring uniformly, adding 30 healthy 4-instar larvae, feeding according to a normal method, and observing the mortality rate for 24h after adding test insects; the experiment was repeated three times and a blank was set.

During the test, the test water was replenished to the initial water volume scale line at intervals 2 d.

The agents were evaluated for activity against the test insects by performing statistical analysis using the DPS data processing software and calculating LC50 for each agent.

And (3) calculating the mortality rate:

from the mortality data, corrected mortality was calculated for each treatment group. If the mortality rate of the control group is less than 5%, no correction is needed, if the mortality rate of the control group is 5% -20%, the correction is needed; the mortality rate exceeds 20%, the test fails and needs to be done again.

P1＝(K/N)×100％……(1)

In the formula (1): p1-mortality; k-number of dead insects; n-total number of insects treated.

P2＝(Pt-P0)/(1-P0)×100％……(2)

In the formula (2): p2-corrected mortality; pt-treatment mortality; p0-blank control mortality.

Calculating toxicity:

using the method of several value analysis, the LC50 value and its 95% confidence limit were found using the computer software.

Calculating the actually measured virulence index of the mixture:

ATI＝S/M×100……(3)

in the formula (3): ATI-measured toxicity index of mixed agent; s — LC50 for standard insecticides; M-LC 50 in admixture.

Calculating the theoretical virulence index of the mixed preparation:

TTI＝TIA×PA+TIB×PB……(4)

in the formula (4): TTI-theoretical virulence index of the mixture; TIA-A agent virulence index; the percentage content of the PA-A medicament in the mixture; TIB-B agent virulence index; the percentage content of the PB-B medicament in the mixture.

And (3) calculating a co-degree coefficient:

CTC＝ATI/TTI×100……(5)

in the formula (5): CTC-co-toxicity coefficient; ATI-measured toxicity index of mixed agent; TTI-theoretical virulence index of the mixture.

The measurement results are as follows (Table-2)

TABLE-2 results of measurements of application examples

By applying each compounding example LD in example 1₅₀And single dose LD₅₀The calculation method calculates the co-toxicity coefficient of the mixture according to the formula for calculating the co-toxicity coefficient of Sunweier, and the calculation result is as follows (Table-3).

Table-3 determination of co-toxicity coefficient of the formulations of the present invention result i:

test results show that when the compounding ratio of flonicamid to pirimiphos-methyl is 1: 80-80: 1, the co-toxicity coefficients are all larger than 130, and have obvious synergistic effect, and particularly when the compounding ratio is 5:1, the co-toxicity coefficient is more than 200.

In addition, similar synergistic effect is achieved when flonicamid is compounded with fenthion and disulfoton, and the specific formula is shown in the following table (table-4):

table-4 determination of co-toxicity coefficient of the formulations of the present invention ii: .

The flonicamid-containing sanitary insecticidal composition and the application thereof have been described by specific examples, and the corresponding other objects can be achieved by appropriately changing the raw materials, the process conditions, the compounding combination or the proportion of the active ingredients and the like by those skilled in the art according to the contents of the invention, and the related changes do not depart from the contents of the invention, and all similar substitutions and changes are obvious to those skilled in the art and are considered to be included in the scope of the invention.