阅读说明：本技术 一种植入式电极装置及植入式生物电刺激系统 (Implanted electrode device and implanted bioelectric stimulation system ) 是由 祁明彰 何庆 唐瑜珅 李晟 吴曦 于 2020-06-30 设计创作，主要内容包括：本发明涉及一种植入式电极装置及植入式生物电刺激系统,所述植入式电极装置包括基体、第一接收元件、第二接收元件、信号处理单元及电极；基体具有外表面和内表面,所述内表面围合形成容纳腔；第一接收元件、第二接收元件及信号处理单元皆设在外表面与所述内表面之间,第一接收元件用于接收外部的中继能量；信号处理单元用于对中继能量进行处理以得到电信号,并将电信号传输至电极；第二接收元件用于接收外部的控制信号,以控制信号处理单元向电极传输电信号；所述电极设置在基体的外表面上,用于将所述电信号作用于目标靶点。该植入式电极装置为集成式结构,可整体固定于患者颅骨上,简化医生的手术操作,避免对患者的日常生活造成不良影响。(The invention relates to an implantable electrode device and an implantable bioelectric stimulation system, wherein the implantable electrode device comprises a substrate, a first receiving element, a second receiving element, a signal processing unit and an electrode; the base body is provided with an outer surface and an inner surface, and the inner surface is enclosed to form a containing cavity; the first receiving element, the second receiving element and the signal processing unit are all arranged between the outer surface and the inner surface, and the first receiving element is used for receiving external relay energy; the signal processing unit is used for processing the relay energy to obtain an electric signal and transmitting the electric signal to the electrode; the second receiving element is used for receiving an external control signal so as to control the signal processing unit to transmit an electric signal to the electrode; the electrode is arranged on the outer surface of the substrate and is used for applying the electric signal to a target point. The implantable electrode device is of an integrated structure, can be integrally fixed on the skull of a patient, simplifies the operation of a doctor, and avoids adverse effects on the daily life of the patient.)

1. An implanted electrode device is characterized by comprising a base body, a first receiving element, a second receiving element, a signal processing unit and an electrode; wherein:

the base body is provided with an outer surface and an inner surface, and the inner surface is enclosed to form an accommodating cavity; the first receiving element, the second receiving element and the signal processing unit are all arranged between the outer surface and the inner surface; the first receiving element is used for receiving external relay energy; the signal processing unit is electrically connected with the first receiving element and the electrode, and is used for processing the relay energy to obtain an electric signal and transmitting the electric signal to the electrode; the second receiving element is electrically connected with the signal processing unit and used for receiving an external control signal so as to control the signal processing unit to transmit the electric signal to the electrode; the electrode is arranged on the outer surface of the substrate and used for applying the electric signal to a target spot.

2. The implantable electrode device of claim 1, wherein the receiving lumen is configured to receive a guidewire.

3. The implantable electrode device according to claim 1, wherein the signal processing unit comprises a printed circuit board and a signal processing circuit etched on the printed circuit board, an input end of the signal processing circuit is electrically connected to the first receiving element and the second receiving element, and an output end of the signal processing circuit is electrically connected to the electrode.

4. The implantable electrode device of claim 3, wherein the printed circuit board is a flexible printed circuit board.

5. The implantable electrode device of claim 3 or 4, wherein the signal processing circuit comprises an amplification circuit and a waveform conversion circuit; the input end of the amplifying circuit is connected with the first receiving element and the second receiving element, the output end of the amplifying circuit is connected with the input end of the waveform conversion circuit, and the output end of the waveform conversion circuit is electrically connected with the electrode.

6. The implantable electrode device of claim 1, wherein the first receiving element is a coupling contact disposed on the signal processing unit; or, the first receiving element is an induction coil.

7. The implantable electrode device of claim 1, wherein the second receiving element is a dipole antenna.

8. The implantable electrode device of claim 1, further comprising a visualization element disposed on an outer surface of the substrate.

9. The implantable electrode device according to claim 1, wherein the base body has a hollow cylindrical structure, the electrodes have an annular structure and are disposed on an outer surface of the base body, and the number of the electrodes is plural, and the plural electrodes are spaced apart from each other along an axial direction of the base body.

10. The implantable electrode device of claim 9, wherein the number of electrodes is four.

11. An implantable bioelectric stimulation system, comprising an implantable electrode arrangement according to any of claims 1-10 and an external control device for transmitting at least one of said relayed energy and said control signal to said implantable electrode arrangement.

12. The implantable bioelectric stimulation system according to claim 11, wherein said external control device comprises an electrical energy transmitter for converting electrical energy into said relayed energy and transmitting said relayed energy to said first receiving element.

13. The implantable bioelectric stimulation system according to claim 11 or 12, wherein said external control device comprises a radio frequency transmitter for transmitting a control signal to said second receiving element.

14. The implantable bioelectric stimulation system according to claim 11, further comprising a guide wire removably disposed in said receiving cavity of said base.

Technical Field

The invention relates to the technical field of medical instruments, in particular to an implantable electrode device and an implantable bioelectric stimulation system.

Background

Parkinson's disease is a common nervous system degenerative disease, which is common in the elderly, with the average age of onset being around 60 years. The most important pathological change of Parkinson's disease is the degenerative death of mesencephalic nigral Dopamine (DA) neurons, which causes a marked reduction in striatal DA content and causes disease. Parkinson's disease mainly presents with resting tremor, bradykinesia, gait disturbance of posture and the like, which can cause great influence on the life of patients.

With the development of modern medical science and technology, the Parkinson's disease can be effectively improved by stimulating the subthalamic nucleus or the internal nucleus of the globus pallidus by using the electrodes. A prior art Deep Brain Stimulation (DBS) system is shown in fig. 1 and includes a pulse generator (generally abbreviated as IPG)10, an extension wire 20, and an electrode 30. When a patient has symptoms of resting tremor, gait disturbance, etc. on one side of the body (only the left or right side of the body), it is often necessary to implant a pulse generator 10, an extension wire 20 and an electrode 30. If the patient's symptoms are bilateral, it is usually necessary to implant one pulse generator 10, two extension wires 20, and two electrodes 30, as shown in fig. 2. The electrodes 30 are typically implanted about 10cm into the brain, with the remainder being embedded subcutaneously in the head, with the other end being placed behind the ear in connection with a subcutaneous extension wire 20, with the extension wire 20 being connected to the pulse generator 10. The pulse generator 10 generates an electrical signal that is transmitted through the subcutaneous extension lead 20 to the electrode 30 and on to the target region of the brain. In performing the implantation, the pulse generator 10 is implanted at a chest location beneath the patient's clavicle and a tunneling channel is then created via a subcutaneous tunneling burr. The distal end of the extension lead 20 is connected with the electrode 30, the electrode 30 reaches the position of the skull opening through the tunneling channel and is implanted into the brain tissue to treat a target area, the electrode 30 is fixed on the skull through a skull fixing device, the middle section of the extension lead 20 is placed in the tunneling channel, and the proximal end of the extension lead 20 is connected with the pulse generator 10.

In the prior art, because the deep brain nerve stimulation electrode comprises a plurality of functional components, and each functional component is distributed on the chest, the neck and the head of a patient, so that a plurality of openings are needed to be formed in the chest, the head and the top of the skull of the patient during an operation, the difficulty and the risk of the operation are relatively large, the wound area of the patient is wide, and the postoperative recovery time is long. After the deep brain nerve stimulation electrode is implanted into a patient, the extension lead is connected with the pulse generator and the electrode through the tunneling channel of the neck, so that great influence is generated on the daily life of the patient, meanwhile, the stress of the extension lead is also generated by the daily neck and head activities of the patient, and the risk of damage and failure of the extension guide is increased.

Disclosure of Invention

The invention aims to provide an implantable electrode device and an implantable bioelectric stimulation system, wherein all components in the implantable electrode device are integrated into a whole, so that the implantable electrode device can generate an electric signal and act the electric signal on a target spot, the implantable electrode device can be integrally implanted into the skull of a patient to reduce the wound area of the patient, and the implantable electrode device does not use a long extension lead, does not need to construct a tunneling channel on the neck and does not influence the daily life of the patient.

In order to achieve the above object, the present invention provides an implantable electrode device, comprising a base, a first receiving element, a second receiving element, a signal processing unit and an electrode; wherein:

the base body is provided with an outer surface and an inner surface, and the inner surface is enclosed to form an accommodating cavity; the first receiving element, the second receiving element and the signal processing unit are all arranged between the outer surface and the inner surface; the first receiving element is used for receiving external relay energy; the signal processing unit is electrically connected with the first receiving element and the electrode, and is used for processing the relay energy to obtain an electric signal and transmitting the electric signal to the electrode; the second receiving element is electrically connected with the signal processing unit and used for receiving an external control signal so as to control the signal processing unit to transmit the electric signal to the electrode; the electrode is arranged on the outer surface of the substrate and used for applying the electric signal to a target spot.

Optionally, the receiving lumen is for receiving a guidewire.

Optionally, the signal processing unit includes a printed circuit board and a signal processing circuit etched on the printed circuit board, an input end of the signal processing circuit is electrically connected to the first receiving element and the second receiving element, and an output end of the signal processing circuit is electrically connected to the electrode.

Optionally, the printed circuit board is a flexible printed circuit board.

Optionally, the signal processing circuit comprises an amplifying circuit and a waveform converting circuit; the input end of the amplifying circuit is connected with the first receiving element and the second receiving element, the output end of the amplifying circuit is connected with the input end of the waveform conversion circuit, and the output end of the waveform conversion circuit is electrically connected with the electrode.

Optionally, the first receiving element is a coupling contact disposed on the signal processing unit; or, the first receiving element is an induction coil.

Optionally, the second receiving element is a dipole antenna.

Optionally, the implantable electrode device further comprises a visualization element disposed on an outer surface of the substrate.

Optionally, the substrate is a hollow cylindrical structure, the electrodes are annular structures and are sleeved on the outer surface of the substrate, the number of the electrodes is multiple, and the multiple electrodes are arranged at intervals along the axial direction of the substrate.

Optionally, the number of electrodes is four.

To achieve the above object, the present invention further provides an implantable bioelectric stimulation system, comprising an external control device and an implantable electrode device as described in any of the preceding claims, wherein the external control device is configured to transmit at least one of the relayed energy and the control signal to the implantable electrode device.

Optionally, the external control device comprises an electrical energy transmitter for converting electrical energy into the relayed energy and transmitting the relayed energy to the first receiving element.

Optionally, the external control device comprises a radio frequency transmitter for transmitting control signals to the second receiving element.

Optionally, the implantable bioelectric stimulation system further comprises a guide wire detachably disposed in the accommodating cavity of the base body.

Compared with the prior art, the implantable electrode device and the implantable biological electrical stimulation system have the following advantages:

the implantable electrode device comprises a substrate, a first receiving element, a second receiving element, a signal processing unit and an electrode; the base body is provided with an outer surface and an inner surface, and the inner surface is enclosed to form an accommodating cavity; the first receiving element, the second receiving element and the signal processing unit are all arranged between the outer surface and the inner surface; the first receiving element is used for receiving external relay energy; the signal processing unit is electrically connected with the first receiving element and the electrode, and is used for processing the relay energy to obtain an electric signal and transmitting the electric signal to the electrode; the second receiving element is electrically connected with the signal processing unit and is used for receiving an external control signal and controlling the signal processing unit to transmit the electric signal to the electrode; the electrode is arranged on the outer surface of the substrate and is used for applying the electric signal to a target point. That is, the first receiving element, the second receiving element and the signal processing unit of the implantable electrode device are used for forming the pulse generating device, and are integrated with the electrodes on the base body, so that the implantable electrode device can generate an electric signal and apply the electric signal to a target point, and therefore, in the operation, only an opening needs to be formed in the skull of a patient to install the whole implantable electrode device, and the patient can be effectively treated. The tunneling channel does not need to be constructed in the operation process, the wound area of a patient is reduced, the postoperative recovery of the patient is facilitated, meanwhile, mutual adverse effects cannot be generated between the implanted electrode device and the daily life of the patient, the use comfort of the patient can be improved, and the service life of the implanted electrode device can be prolonged.

And secondly, the signal processing unit comprises a printed circuit board etched with a signal processing circuit, and particularly, when the printed circuit board is a flexible printed circuit board, the manufacturing difficulty of the implanted electrode device can be effectively reduced.

Drawings

FIG. 1 is a schematic diagram of a deep brain nerve stimulation electrode of the prior art;

FIG. 2 is a schematic illustration of a prior art deep brain nerve stimulation electrode implanted in a patient, illustrating both electrodes co-implanted;

FIG. 3 is a schematic structural diagram of an implantable electrode device according to an embodiment of the present invention;

fig. 4 is a schematic diagram of an electrical energy transmission technique between a microwave emission source and a first receiving element of an external control device in an implantable bioelectric stimulation system according to an embodiment of the present invention.

[ reference numerals are described below ]:

10-pulse generator, 20-extension wire, 30, 300-electrode;

100-a substrate;

210-a first receiving element, 220-a second receiving element, 230-a signal processing unit;

400-a developing element;

500-a microwave emission source;

600-guide wire.

Detailed Description

The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It should be noted that the drawings provided in the present embodiment are only for illustrating the basic idea of the present invention, and the components related to the present invention are only shown in the drawings rather than drawn according to the number, shape and size of the components in actual implementation, and the type, quantity and proportion of the components in actual implementation may be changed freely, and the layout of the components may be more complicated.

Furthermore, each of the embodiments described below has one or more technical features, and thus, the use of the technical features of any one embodiment does not necessarily mean that all of the technical features of any one embodiment are implemented at the same time or that only some or all of the technical features of different embodiments are implemented separately. In other words, those skilled in the art can selectively implement some or all of the features of any embodiment or combinations of some or all of the features of multiple embodiments according to the disclosure of the present invention and according to design specifications or implementation requirements, thereby increasing the flexibility in implementing the invention.

As used in this specification, the singular forms "a", "an" and "the" include plural referents, and the plural forms "a plurality" includes more than two referents unless the content clearly dictates otherwise. As used in this specification, the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise, and the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either fixedly connected, detachably connected, or integrally connected. Either mechanically or electrically. Either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations. The same or similar reference numbers in the drawings identify the same or similar elements.

The core idea of the invention is to provide an implantable electrode device, which is applied to an implantable bioelectric stimulation system, compared with the traditional deep brain nerve stimulation electrode, through the integrated design of a plurality of electronic elements, the implantable electrode device can generate a pulse electric signal and directly act on a target spot through an electrode. That is, the implantable electrode device of the present invention does not need to be additionally provided with an extension wire for connecting a pulse generator, and thus, a tunneling channel is not required to be constructed. Therefore, the operation of a doctor can be simplified, the operation time can be shortened, the operation risk can be reduced, the wound area of a patient can be reduced, the postoperative recovery of the patient can be facilitated, the influence on the daily life of the patient caused by the fact that the extension lead is implanted into the neck of the patient can be avoided, and meanwhile, the service life of the implantable electrode device is prevented from being shortened due to the fact that the implantable electrode device is subjected to the action of external force in the daily life of the patient.

In order to achieve an integrated design of the implantable electrode arrangement, the implantable electrode arrangement comprises a base body, a first receiving element, a second receiving element, a signal processing unit and an electrode. The first receiving element, the second receiving element and the signal processing unit are all arranged in the substrate, and the electrodes are arranged on the outer surface of the substrate, so that all electronic elements are integrated on the substrate and are not connected with one another through long extension leads. During surgery, the physician merely opens a hole in the skull of the patient and secures the implantable electrode device to the skull. In the implantable electrode device, the first receiving element is configured to receive external relay energy, the signal processing unit is configured to process the relay energy to obtain an electrical signal and transmit the electrical signal to the electrode, and the second receiving element is configured to receive an external control signal to control the signal processing unit to transmit the electrical signal to the electrode. The base body is provided with an accommodating cavity so that the base body is provided with an inner surface, and the first receiving element, the second receiving element and the signal processing unit are arranged between the inner surface and the outer surface of the base body. The signal processing unit comprises a printed circuit board and a signal processing circuit etched on the printed circuit board, and the signal processing circuit is used for processing the relay energy to obtain an electric signal and transmitting the electric signal to the electrode. Preferably, the printed circuit board is a flexible printed circuit board, and the first receiving element and the second receiving element are both disposed on the printed circuit board. Thus, by bending the flexible printed circuit board, the printed circuit board can be guided between the inner surface and the outer surface of the base body. Therefore, the purpose of integrating the first receiving element, the second receiving element and the signal processing circuit on the substrate is achieved.

Furthermore, the embodiment of the invention also provides an implanted bioelectric stimulation system, which comprises an external control device and the implanted electrode device, wherein the external control device is used for transmitting relay energy and control signals to the implanted electrode device

To make the objects, advantages and features of the present invention more apparent, the implantable bioelectric stimulation system provided by the present invention will be described in further detail with reference to the accompanying drawings and preferred embodiments. It is to be noted that the drawings are in a very simplified form and are not to precise scale, which is merely for the purpose of facilitating and distinctly claiming the embodiments of the present invention.

Fig. 3 is a schematic structural diagram of an implantable electrode device according to an embodiment of the present invention. As shown in fig. 3, an embodiment of the present invention relates to an implantable electrode device, including a base 100, a first receiving element 210, a second receiving element 220, a signal processing unit 230, and an electrode 300. Wherein the substrate 100 has an outer surface and an inner surface, the inner surface enclosing to form a receiving cavity. The first receiving element 210, the second receiving element 220 and the signal processing unit 230 are all disposed between the outer surface and the inner surface (i.e. an interlayer is formed between the outer surface and the inner surface, and the first receiving element, the second receiving element and the signal processing unit are all disposed in the interlayer) and are used to jointly constitute a pulse generating device. In detail, the first receiving element 210 is configured to receive the relay energy from the outside. The signal processing unit 230 is electrically connected to the first receiving element 210 and the electrode 300, and the signal processing unit 230 is configured to process the relay energy to obtain an electrical signal and transmit the electrical signal to the electrode 300. The second receiving element 220 is also electrically connected to the signal processing unit 230 and is configured to receive a control signal from the outside, so as to control the signal processing unit 230 to transmit an electrical signal to the electrode 300 according to the control signal. The electrode 300 is disposed on an outer surface of the substrate 100 and serves to apply an electrical signal to a target point of interest.

In other words, the present invention provides an implantable electrode device, in which all the electronic components are disposed on the substrate 100, so that the implantable electrode device can generate an electric signal by itself and apply the electric signal to a target, and thus the implantable electrode device does not need to be connected to the pulse generator through an extension wire. The implanted electrode device is integrally in a slender rod shape, one end of the implanted electrode device extends into brain tissue below a skull, and the other end of the implanted electrode device is directly fixed with the skull. The doctor only needs to open a hole on the head of the patient during the operation, so that the operation difficulty is reduced, the operation time is saved, the wound area of the patient is reduced, and the postoperative recovery of the patient is facilitated.

Further, the signal processing unit 230 includes a printed circuit board and a signal processing circuit etched on the printed circuit board, and the signal processing circuit is configured to process the relay energy received by the first receiving element 210 so as to convert the relay energy into an electrical signal. Optionally, the signal processing circuit includes an amplifying circuit and a waveform converting circuit, wherein an input terminal of the amplifying circuit is electrically connected to the first receiving element 210, an output terminal of the amplifying circuit is connected to an input terminal of the waveform converting circuit, and an output terminal of the waveform converting circuit is electrically connected to the electrode 300. In this way, the relay energy received by the first receiving element 210 is processed by the signal processing circuit and then converted into an electrical signal, and the electrical signal is transmitted to the electrode 300, and then acted on a target by the electrode 300, so as to perform electrical stimulation treatment on a patient.

The Printed Circuit board is preferably a Flexible Printed Circuit (PFC). The flexible printed circuit board has the characteristics of small size, light weight, thinness, softness and flexibility on the basis of providing excellent electric conductivity, meets the design requirement of high-density installation, and can be freely bent, wound and folded according to spatial layout so as to achieve the purpose of integrating the assembly of electronic components and the connection of wires. That is, the signal processing circuit is etched on the flexible printed circuit board, and the first receiving element 210 and the second receiving element 220 are disposed on the flexible printed circuit board, and by bending the flexible printed circuit board, the first receiving element 210, the second receiving element 220 and the signal processing circuit can be conveniently and integrally disposed between the outer surface and the inner surface of the substrate 100, thereby reducing the difficulty in manufacturing the implantable electrode device. In addition, the flexible printed circuit board also has good heat dissipation and reliability, and can meet the requirement of performance stability of the implanted electrode device.

The signal processing unit 230 is arranged between the inner surface and the outer surface of the base body 100, so that the volume of the electrode device for implantation is reduced as much as possible, the outer surface of the base body 100 is not uneven, the outer surface of the base body 100 is smooth, and the damage to the skull is reduced.

Alternatively, the number of the first receiving elements 210 is two, and the two first receiving elements 210 are arranged on the printed circuit board at intervals along the axial direction of the base body 100. Preferably, two first receiving elements 210 are disposed adjacent to both axial sides of the printed circuit board, respectively. In addition, the second receiving element 220 may be a dipole antenna, and the external control signal received by the second receiving element is a radio frequency control signal, so that the signal processing unit 230 transmits a pulse electrical signal to the electrode 300.

In the present embodiment, the implantable electrode device generates an electrical signal using Wireless Power Transfer (WPT) technology. That is, after the implantable electrode device is implanted in the skull, an external control device converts the electric energy into relay energy, and then transmits the relay energy, and the relay energy is received by the first receiving element 210, transmitted to the signal processing unit 230 (as shown in fig. 4), processed by the signal processing unit 230, and then converted into an electric signal. Optionally, in some implementations, the implantable electrode device performs Wireless Power transmission by using Inductive Wireless Power Transfer (IWPT), that is, performs Power transmission by using the principle of electromagnetic induction, so that the relay energy may be magnetic field energy, and the first receiving element 210 may be an induction coil. In other implementations, the implantable electrode device performs wireless transmission of electric energy by using electrical radiation Coupling (i.e., relaying energy is electromagnetic wave), and the first receiving element 210 is a Coupling contact disposed on the signal processing unit 230. In this embodiment, it is preferable to use the electromagnetic radiation mode to perform wireless transmission of electric energy, because the electromagnetic radiation can realize long-distance transmission, and the external control device is not limited by a specific location, so that the use is more convenient and flexible.

Further, the implantable electrode device further comprises a visualization element 400, and the visualization element 400 is disposed on the outer surface of the substrate 100. During the operation, the doctor determines the position of the substrate 100 on the head of the patient by means of an imaging device such as a tomography, and based on the developing member 400. In this embodiment, the visualization element 400 is a visualization ring, and the visualization element 400 can be made of various radiopaque visualization materials.

In addition, in the present embodiment, the number of the electrodes 300 may be plural (plural includes two or more), and the plural electrodes 300 are arranged at intervals along the axial direction of the base 100. In a preferred embodiment, the number of the electrodes 300 may be set to four for performing electrical stimulation therapy on four target points of the head of the patient.

Further, the implantable electrode device of the present embodiment is used with an external control device to form an implantable bioelectric stimulation system. The external control device is used to control the signal processing unit 230 to generate a pulse electrical signal, that is, the external control device may transmit relay energy to the first receiving element 210 and transmit a control signal to the second receiving element 220. In particular, the external control device may include a power transmitter and a radio frequency signal transmitter. Wherein the electric energy transmitter is configured to convert the electric energy into relay energy and transmit the relay energy to the first receiving element 210. In this embodiment, the power transmitter may be a microwave transmitting source 500, so as to cooperate with the coupling contact to realize the electric radiation coupling transmission of the power. The radio frequency signal transmitter is used to transmit a control signal to the second receiving element 220.

Generally, the substrate 100 is made of polycarbonate or polyurethane, and is designed to be a hollow cylindrical structure, and the substrate 100 is relatively soft and flexible, and is not easy to implant. Based on this, the implanted bioelectric stimulation system further comprises a guide wire 500, and the guide wire 500 is relatively hard and can be used for assisting implantation. Specifically, during the operation, the guide wire 500 is inserted into the receiving cavity of the base 100, and the base 100 is supported by the guide wire 500, so that the base 100 maintains axial rigidity and is not easily deformed. During implantation, the physician may also perform an intraoperative examination using the guidewire 500 in conjunction with an intraoperative testing device to determine whether the substrate 100 is implanted at the desired location. After the matrix 100 is implanted in place, the physician affixes the matrix 100 to the skull of the patient and withdraws the guide wire from the matrix 100. It is to be understood that the base 100 may be secured to the patient's skull using a conventional skull lock. In another embodiment, one end of the electrode 300 is connected to the outer surface of the base 100, and the other end extends from the outer surface of the base 100 to form a bayonet for connecting the implantable electrode device to the cranial crown.

The implantable electrode device provided by the embodiment of the invention comprises a base body, a first receiving element, a second receiving element, a signal processing unit and an electrode. The base body is provided with an outer surface and an inner surface, the inner surface is enclosed to form an accommodating cavity, and the first receiving element, the second receiving element and the signal processing unit are arranged between the outer surface and the inner surface; the first receiving element is used for receiving external relay energy, the signal processing unit is connected with the first receiving unit and the electrode and used for processing the relay energy to obtain an electric signal and transmitting the electric signal to the electrode, and the second receiving unit is connected with the signal processing unit and used for receiving an external control signal and controlling the signal processing unit to transmit the electric signal to the electrode. The electrode is arranged on the outer surface of the substrate and is used for applying an electric signal to a target point. The implanted electrode device can generate an electric signal, can act on a target spot, and is integrally implanted into the skull of a patient, so that the operation of a doctor is simplified, the operation risk is reduced, the postoperative recovery of the patient is facilitated, and the daily life of the patient is not influenced.

Although the present invention is disclosed above, it is not limited thereto. Various modifications and alterations of this invention may be made by those skilled in the art without departing from the spirit and scope of this invention. Thus, if such modifications and variations of the present invention fall within the scope of the equivalent techniques of the present invention, it is intended that the present invention encompass such modifications and variations as well.