阅读说明：本技术 一种用于平疮消炎化腐生肌的药物组合物及其制备方法 (A pharmaceutical composition for relieving sore, diminishing inflammation, removing necrotic tissue, and promoting granulation, and its preparation method ) 是由 田利珍 于 2021-03-10 设计创作，主要内容包括：本发明公开了一种用于平疮消炎化腐生肌的药物组合物及其制备方法,该组合物包含：乳香、没药、香油、樟丹、麝香。该组合物还包含：桑树枝、槐树枝、桃树枝、榆树枝、柳树枝。本发明还提供了该用于平疮消炎化腐生肌的药物组合物的制备方法。本发明提供的用于平疮消炎化腐生肌的药物组合物及其制备方法,所得的药物组合物可以制备外敷膏药,具有止疼、平疮、消炎、化腐生肌、可自行脱出小死骨或异物等功效,还具有用药时间短、起效快、经济、简便、疗效好等特点。(The invention discloses a pharmaceutical composition for treating sore, diminishing inflammation, removing necrotic tissue and promoting granulation and a preparation method thereof, wherein the composition comprises the following components: frankincense, myrrh, sesame oil, minium and musk. The composition further comprises: mulberry branch, pagodatree branch, peach branch, elm branch, willow branch. The invention also provides a preparation method of the pharmaceutical composition for treating sore, diminishing inflammation, removing necrotic tissue and promoting granulation. The medicinal composition for relieving sore, diminishing inflammation, removing necrotic tissue and promoting granulation and the preparation method thereof provided by the invention can be used for preparing an external plaster, has the effects of relieving pain, relieving sore, diminishing inflammation, removing necrotic tissue and promoting granulation, can automatically remove small dead bones or foreign bodies and the like, and has the characteristics of short administration time, quick response, economy, simplicity, good curative effect and the like.)

1. A pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, comprising: frankincense, myrrh, sesame oil, minium and musk.

2. The pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation as claimed in claim 1, wherein said composition comprises by weight: 35-45 parts of frankincense, 35-45 parts of myrrh, 700-800 parts of sesame oil, 200-300 parts of minium and 0.5-1.5 parts of musk.

3. The pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation of claim 2, wherein said composition comprises, in parts by weight: 40 parts of frankincense, 40 parts of myrrh, 750 parts of sesame oil, 250 parts of minium and 1 part of musk.

4. The pharmaceutical composition for treating sores, diminishing inflammation, removing necrotic tissue and promoting granulation as claimed in claim 3, wherein said composition comprises by weight: 40g of frankincense, 40g of myrrh, 750g of sesame oil, 250g of minium and 1g of musk.

5. The pharmaceutical composition for treating sores, diminishing inflammation, removing necrotic tissue and promoting granulation of claim 1, wherein said composition further comprises: mulberry branch, pagodatree branch, peach branch, elm branch, willow branch.

6. A method for preparing the pharmaceutical composition for relieving sore inflammation, removing necrotic tissue and promoting granulation as claimed in any one of claims 1 to 5, wherein said method comprises:

step 1, weighing and processing raw materials;

step 2, putting the sesame oil into an earthen pot, after the oil is boiled, putting the mulberry tree branch, the pagoda tree branch, the peach tree branch, the elm tree branch and the willow tree branch into the earthen pot, and fishing out the branches by using a strainer after the branches are fried to be scorched;

step 3, adding frankincense and myrrh into the oil fried in the step 2, and decocting into a viscous ointment;

step 4, adding minium into the ointment obtained in the step 3, and uniformly mixing;

and 5, cooling the mixture obtained in the step 4 to 55-65 ℃, adding musk into the mixture, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain the ointment.

7. The method for preparing a pharmaceutical composition for treating flat sores, diminishing inflammation, removing necrotic tissue and promoting granulation as claimed in claim 6, wherein the treatment in step 1 is grinding olibanum and myrrh into powder; the particle size range of the powder is 40-60 meshes.

8. The method for preparing a pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation as claimed in claim 7, wherein said treating in step 1 further comprises cutting the mulberry branch, the locust tree branch, the peach branch, the elm branch and the willow branch into several segments, each of which has a length of 2 feet of the thickness of the chopsticks.

9. The preparation method of the pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation as claimed in claim 6, wherein said pharmaceutical composition is used for preparing an external plaster.

10. The method for preparing a pharmaceutical composition for relieving sore inflammation, removing necrotic tissue and promoting granulation as claimed in claim 9, wherein said topical plaster is prepared by spreading the obtained ointment, and the diameter of each plaster is about 8-10 cm.

Technical Field

The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for relieving sore, diminishing inflammation, removing necrotic tissue and promoting granulation and a preparation method thereof.

Background

Sores, in general, refer to the condition of ulcerated sores on the skin. Such as: bedsore, chilblain, sore mouth, scab, burn sore and the like, which are troubling many people with orthopedic diseases. Among them, bedsore is due to long-term compression of local tissues, tissue ulceration and necrosis caused by continuous ischemia, hypoxia and malnutrition, and is often seen in patients who are in bed, in wheelchairs and the like, who do not change their posture for a long time, such as patients with spinal cord injury, paralysis, coma or lower limb fracture, and is prone to get bedsore, and to cause sore mouth suppuration and difficult healing.

The common diabetes mellitus is easy to cause the complication of peripheral vascular diseases, and can cause the occlusion of blood vessels, the termination of blood flow, the reduction of the immunity function of the organism and the invasion of pathogens, wherein bacterial infection is the most common, and the limbs are ulcerated and even necrotized.

Common orthopedic diseases include chronic osteomyelitis, bone tuberculosis, and the like.

Chronic osteomyelitis is usually asymptomatic or local, and often manifests as skin pigmentation at the affected area, repeated pus discharge, or small bone discharge.

Bone tuberculosis is a destructive disease caused by the invasion of tubercle bacillus into bones or joints. The affected part is mostly in bones or joints which are serious in burden, move more and easily produce strain. Preferably, the hair site is the spine, followed by hips, knees, feet, elbows, hands, etc.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition and a preparation method thereof, which can solve the existing problems, have the efficacies of relieving pain, removing sores, diminishing inflammation, removing necrotic tissue, promoting granulation, automatically removing small dead bones or foreign bodies and the like, and have the characteristics of short administration time, quick response, economy, simplicity, good curative effect and the like.

In order to achieve the above objects, the present invention provides a pharmaceutical composition for treating sore, diminishing inflammation, removing necrotic tissue and promoting granulation, wherein the composition comprises: frankincense, myrrh, sesame oil, minium and musk.

The pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation comprises the following components in parts by weight: 35-45 parts of frankincense, 35-45 parts of myrrh, 700-800 parts of sesame oil, 200-300 parts of minium and 0.5-1.5 parts of musk.

The pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation comprises the following components in parts by weight: 40 parts of frankincense, 40 parts of myrrh, 750 parts of sesame oil, 250 parts of minium and 1 part of musk.

The pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation comprises the following components in parts by weight: 40g of frankincense, 40g of myrrh, 750g of sesame oil, 250g of minium and 1g of musk.

The pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, wherein the composition further comprises: mulberry branch, pagodatree branch, peach branch, elm branch, willow branch.

The invention also provides a preparation method of the pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, wherein the method comprises the following steps: step 1, weighing and processing raw materials; step 2, putting the sesame oil into an earthen pot, after the oil is boiled, putting the mulberry tree branch, the pagoda tree branch, the peach tree branch, the elm tree branch and the willow tree branch into the earthen pot, and fishing out the branches by using a strainer after the branches are fried to be scorched; step 3, adding frankincense and myrrh into the oil fried in the step 2, and decocting into a viscous ointment; step 4, adding minium into the ointment obtained in the step 3, and uniformly mixing; and 5, cooling the mixture obtained in the step 4 to 55-65 ℃, adding musk into the mixture, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain the ointment.

The preparation method of the pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation comprises the following steps of (1) grinding frankincense and myrrh into powder; the particle size range of the powder is 40-60 meshes.

The preparation method of the pharmaceutical composition for relieving sore inflammation, removing necrotic tissue and promoting granulation comprises the following steps of taking 2 feet of the thickness of each of mulberry branch, pagodatree branch, peach branch, elm branch and willow branch, and cutting into a plurality of sections.

The preparation method of the pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation is characterized in that the pharmaceutical composition is used for preparing an external plaster.

The preparation method of the pharmaceutical composition for relieving sore inflammation, removing necrotic tissue and promoting granulation is characterized in that the externally applied plaster is prepared by spreading the obtained plaster, and each plaster is 8-10 cm in diameter.

The pharmaceutical composition for relieving sore, diminishing inflammation, removing necrotic tissue and promoting granulation and the preparation method thereof provided by the invention have the following advantages:

the pharmaceutical composition for relieving sore, diminishing inflammation, removing necrotic tissue and promoting granulation provided by the invention has the effects of relieving pain, relieving sore, diminishing inflammation, removing necrotic tissue and promoting granulation, can automatically remove small dead bones or foreign bodies and the like, and has the characteristics of short administration time, quick response, economy, simplicity, good curative effect and the like.

The preparation of the invention can be used for skin swelling and ulcer, external sores, bedsores, burns and sores, chronic osteomyelitis, bone tuberculosis, diabetes, hand and foot necrosis and the like; has the characteristics of reasonable formula, small dosage, obvious effect, no toxic or side effect, low recurrence rate and the like.

Detailed Description

The following further describes embodiments of the present invention.

The invention provides a pharmaceutical composition for removing sore, diminishing inflammation, removing necrotic tissue and promoting granulation, which comprises the following components in part by weight: frankincense, myrrh, sesame oil, minium and musk. The raw materials of the medicines respectively accord with the corresponding national standards.

Wherein the Olibanum is resin exuded from bark of Boswellia serrata belonging to Burseraceae and the same genus plant. The milk is classified into the species of frankincense somarie and the species of frankincense esophora, each of which is also in turn the same as the bead of frankincense and the original frankincense. Pungent, bitter and warm in nature. It enters heart, liver and spleen meridians. Has effects of promoting blood circulation, activating qi-flowing, relieving pain, eliminating swelling and promoting granulation. Can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal pain, rheumatic arthralgia, spasm of muscles and tendons, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Myrrha is dried resin of herba Violae or herba corydalis Thalictrifoliae of Burseraceae. Is divided into natural myrrh and colloid myrrh. Distributed in somari, russian and south Arabian peninsula. Pungent and bitter in flavor and mild in nature. It enters heart, liver and spleen meridians. Has effects in removing blood stasis, relieving pain, eliminating swelling, and promoting granulation. Can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal mass, rheumatic arthralgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

The minium, also called as minium, red lead powder, cinnabar powder and plumbum flower, is made up by using lead, sulfur and saltpeter through a certain preparation process. Pungent, slightly cold and toxic. The minium has wide application range, and has the effects of eliminating phlegm and timidity, removing food retention and killing parasites, diarrhea, malaria, relieving fever and drawing out toxin.

Moschus is secretion of the glandular sac of male animal of deer Moschus. The incense is taken 1 time in winter and spring every year, and is also taken 2 times in 3 and 4 months and 7 and 8 months every year. In the past, the male musk deer is hunted in winter and spring, and the musk sac is cut off from the belly skin and dried in the shade. The whole musk is obtained by cutting the hair short, which is also called feather incense. The musk particles in the capsule are dug and called musk kernel, which is also called dispersing fragrance. Pungent and warm in nature and flavor. Enter heart, spleen and liver meridians. The functions are as follows: inducing resuscitation, removing filth, dredging collaterals, and removing blood stasis. Can be used for treating apoplexy, phlegm syncope, epilepsy, vexation, heart and abdominal pain, abdominal mass, traumatic injury, carbuncle, cellulitis, and toxic swelling.

Sesame oil is extracted from sesame, has special fragrance, and is called sesame oil. The sesame oil contains unsaturated fatty acid and amino acid essential to human body, and also contains abundant vitamins and microelements such as iron, zinc and copper essential to human body, and its cholesterol content is far lower than that of animal fat. It has effects of loosening bowel to relieve constipation, and is suitable for patients with arteriosclerosis, hypertension, coronary heart disease, hyperlipidemia, diabetes, constipation, ascaris intestinal obstruction, etc.

Preferably, the composition comprises, in parts by weight: 35-45 parts of frankincense, 35-45 parts of myrrh, 700-800 parts of sesame oil, 200-300 parts of minium and 0.5-1.5 parts of musk.

More preferably, the composition comprises, in parts by weight: 40 parts of frankincense, 40 parts of myrrh, 750 parts of sesame oil, 250 parts of minium and 1 part of musk.

Most preferably, the composition comprises by weight: 40g of frankincense, 40g of myrrh, 750g of sesame oil, 250g of minium and 1g of musk.

The composition further comprises: mulberry branch, pagodatree branch, peach branch, elm branch, willow branch.

Wherein the ramulus Mori is ramulus Mori, and dried tender branch of Morus alba L. Collected in late spring and early summer, leaves removed, and dried in the sun, or sliced and dried in the sun when the tea is fresh. Slightly bitter taste and mild nature. It enters liver meridian. Has the functions of expelling wind-damp and benefiting joints. Can be used for treating rheumatism, shoulder pain, arm pain, and arthralgia.

The branch of Sophora japonica is the twig of Sophora japonica of Leguminosae and contains rutin. It is generally cultivated around the house and roadside. Oral administration: decocting, soaking in wine or making into powder. External use: decocting, fumigating, washing or heating to leach. The main functional indications are as follows: it is indicated for metrorrhagia, metrostaxis, leukorrhagia, heart pain, conjunctival congestion, bedsore and scabies.

The peach branch is peach branch, and is dried branch of peach of Rosaceae. Collected in summer, cut into segments and dried in the sun. Is generally cultivated in China. Bitter taste and mild nature. It enters heart and liver meridians. Has the effects of promoting blood circulation, dredging collaterals, removing toxic substance and killing parasite. Can be used for treating heart and abdomen stabbing pain, rheumatalgia, traumatic injury, skin ulcer, and tinea.

The branch of Ulmus pumila is the branch of Ulmus pumila of Ulmaceae. Collecting branches in summer and autumn, and fresh or sun drying. Collecting raw materials, removing impurities, slightly soaking, cleaning, moistening, slicing, and drying. Sweet in flavor and neutral in nature. Has the effects of inducing diuresis for treating stranguria. It is commonly used for stranguria due to qi.

The willow branch is willow branch of Salix babylonica of Salicaceae. Distributed in Yangtze river and yellow river basin, and cultivated in other areas. Bitter taste and cold nature. It enters stomach and liver meridians. Has the functions of dispelling wind, promoting diuresis, detoxicating and eliminating swelling. It is commonly used for treating rheumatic arthralgia, stranguria with turbid urine, jaundice, rubella, pruritus, furuncle, erysipelas, dental caries, and gingival swelling.

The invention also provides a preparation method of the pharmaceutical composition for treating sore, diminishing inflammation, removing necrotic tissue and promoting granulation, which comprises the following steps: step 1, weighing and processing raw materials; step 2, putting the sesame oil into an earthen pot, after the oil is boiled, putting the mulberry tree branch, the pagoda tree branch, the peach tree branch, the elm tree branch and the willow tree branch into the earthen pot, and fishing out the branches by using a strainer after the branches are fried to be scorched; step 3, adding frankincense and myrrh into the oil fried in the step 2, decocting into a viscous ointment, and dripping into beads; step 4, adding minium into the ointment obtained in the step 3, and uniformly mixing; and 5, cooling the mixture obtained in the step 4 to room temperature or feeling not too hot, adding musk, and uniformly stirring to obtain the ointment.

Preferably, the treatment in step 1 is grinding Olibanum, Myrrha into powder; the particle size range of the powder is 40-60 meshes.

The treatment in the step 1 also comprises that the mulberry branch, the pagoda branch, the peach branch, the elm branch and the willow branch are respectively taken to be 2 feet long of the thickness of the chopsticks and then cut into a plurality of sections.

The pharmaceutical composition can be used for preparing topical plaster.

The pharmaceutical composition for removing inflammation, removing necrotic tissue and promoting granulation and the preparation method thereof provided by the present invention are further described below with reference to the examples.

Example 1

A pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, the composition comprising: frankincense, myrrh, sesame oil, minium and musk. The raw materials of the medicines respectively accord with the corresponding national standards.

Preferably, the composition comprises, in parts by weight: 40 parts of frankincense, 40 parts of myrrh, 750 parts of sesame oil, 250 parts of minium and 1 part of musk.

More preferably, the composition comprises by weight: 40g of frankincense, 40g of myrrh, 750g of sesame oil, 250g of minium and 1g of musk.

The composition further comprises: mulberry branch, pagodatree branch, peach branch, elm branch, willow branch.

The embodiment also provides a preparation method of the pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, which comprises the following steps:

step 1, weighing each raw material and processing.

Grinding Olibanum and Myrrha into powder; the particle size range of the powder is 40-60 meshes.

The mulberry branch, the pagodatree branch, the peach branch, the elm branch and the willow branch are respectively cut into a plurality of sections after the length of 2 feet of the thickness of the chopsticks.

And 2, putting the sesame oil into an earthen pot, after the oil is boiled, putting the mulberry tree branch, the pagoda tree branch, the peach tree branch, the elm tree branch and the willow tree branch into the earthen pot, and fishing out the branches by using a strainer after the branches are fried to be scorched.

And 3, adding frankincense and myrrh into the oil fried in the step 2, and decocting into a viscous ointment.

And 4, adding minium into the ointment obtained in the step 3, and uniformly mixing.

And 5, cooling the mixture obtained in the step 4 to 55-65 ℃, adding musk into the mixture, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain the ointment.

The pharmaceutical composition can be used for preparing topical plaster. The externally-applied plaster is prepared by spreading the obtained plaster, and each plaster has the diameter of about 8-10 cm.

Example 2

A pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, the composition comprising: frankincense, myrrh, sesame oil, minium and musk. The raw materials of the medicines respectively accord with the corresponding national standards.

Preferably, the composition comprises, in parts by weight: 35 parts of frankincense, 35 parts of myrrh, 700 parts of sesame oil, 200 parts of minium and 0.5 part of musk.

More preferably, the composition comprises by weight: 35g of frankincense, 35g of myrrh, 700g of sesame oil, 200g of minium and 0.5g of musk.

The composition further comprises: mulberry branch, pagodatree branch, peach branch, elm branch, willow branch.

The embodiment also provides a preparation method of the pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, which comprises the following steps:

step 1, weighing each raw material and processing.

Grinding Olibanum and Myrrha into powder; the particle size range of the powder is 40-60 meshes.

The mulberry branch, the pagodatree branch, the peach branch, the elm branch and the willow branch are respectively cut into a plurality of sections after the length of 2 feet of the thickness of the chopsticks.

And 2, putting the sesame oil into an earthen pot, after the oil is boiled, putting the mulberry tree branch, the pagoda tree branch, the peach tree branch, the elm tree branch and the willow tree branch into the earthen pot, and fishing out the branches by using a strainer after the branches are fried to be scorched.

And 3, adding frankincense and myrrh into the oil fried in the step 2, and decocting into a viscous ointment.

And 4, adding minium into the ointment obtained in the step 3, and uniformly mixing.

And 5, cooling the mixture obtained in the step 4 to 55-65 ℃, adding musk into the mixture, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain the ointment.

The pharmaceutical composition can be used for preparing topical plaster. The externally-applied plaster is prepared by spreading the obtained plaster, and each plaster has the diameter of about 8-10 cm.

Example 3

A pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, the composition comprising: frankincense, myrrh, sesame oil, minium and musk. The raw materials of the medicines respectively accord with the corresponding national standards.

Preferably, the composition comprises, in parts by weight: 45 parts of frankincense, 45 parts of myrrh, 800 parts of sesame oil, 300 parts of minium and 1.5 parts of musk.

More preferably, the composition comprises by weight: 45g of frankincense, 45g of myrrh, 800g of sesame oil, 300g of minium and 1.5g of musk.

The composition further comprises: mulberry branch, pagodatree branch, peach branch, elm branch, willow branch.

The embodiment also provides a preparation method of the pharmaceutical composition for treating sore inflammation, removing necrotic tissue and promoting granulation, which comprises the following steps:

step 1, weighing each raw material and processing.

Grinding Olibanum and Myrrha into powder; the particle size range of the powder is 40-60 meshes.

The mulberry branch, the pagodatree branch, the peach branch, the elm branch and the willow branch are respectively cut into a plurality of sections after the length of 2 feet of the thickness of the chopsticks.

And 2, putting the sesame oil into an earthen pot, after the oil is boiled, putting the mulberry tree branch, the pagoda tree branch, the peach tree branch, the elm tree branch and the willow tree branch into the earthen pot, and fishing out the branches by using a strainer after the branches are fried to be scorched.

And 3, adding frankincense and myrrh into the oil fried in the step 2, and decocting into a viscous ointment.

And 4, adding minium into the ointment obtained in the step 3, and uniformly mixing.

And 5, cooling the mixture obtained in the step 4 to 55-65 ℃, adding musk into the mixture, uniformly stirring the mixture, and cooling the mixture to room temperature to obtain the ointment.

The pharmaceutical composition can be used for preparing topical plaster. The externally-applied plaster is prepared by spreading the obtained plaster, and each plaster has the diameter of about 8-10 cm.

Patients were selected at random and divided into experimental and control groups of 200 patients each. Experimental group the composition prepared in example 1 of the present invention was used in an amount adjusted according to the area of the affected part. After all patients in the available experimental groups take the medicine, the effect rate reaches 98%, the obvious effect rate reaches 94%, the cure rate reaches 86%, and basically no relapse occurs.

According to the pharmaceutical composition for treating sore, diminishing inflammation, removing necrotic tissue and promoting granulation and the preparation method thereof, through the differentiation of the traditional Chinese medicine, aiming at the etiology and pathogenesis of diseases and by utilizing the compatibility principle that medicines supplement each other, the medicines are purposefully and reasonably combined according to the monarch, minister, assistant and guide tissue structures, the medicines in the formula and the compatibility thereof are screwed into the pathogenesis of the diseases, and the comprehensive effect after the medicines are combined is highly unified with the established treatment method. The prepared composition has the effects of relieving pain, removing sore, diminishing inflammation, removing necrotic tissue, promoting granulation, automatically removing small dead bones or foreign bodies and the like, and has the characteristics of short administration time, quick response, economy, simplicity, good curative effect and the like.

While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.