阅读说明：本技术 含次氯酸和硅烷季铵的消毒和抗微生物溶液 (Disinfecting and antimicrobial solutions containing hypochlorous acid and silane quats ) 是由 P·E·艾迪 C·A·艾迪 于 2020-11-11 设计创作，主要内容包括：一种消毒和抗微生物溶液,包含：次氯酸；硅烷季铵离子或其盐；以及水。次氯酸可以以0.1至1000ppm的浓度存在于溶液中。硅烷季铵离子或其盐可以是以下中的一种或多种：3-(三甲氧基甲硅烷基)丙基二甲基十八烷基铵离子、3-(三甲氧基甲硅烷基)丙基二甲基十八烷基氯化铵、3-(三羟基甲硅烷基)丙基二甲基十八烷基铵离子以及3-(三羟基甲硅烷基)丙基二甲基十八烷基氯化铵。硅烷季铵离子或其盐可以是溶液的0.1至10重量％。消毒和抗微生物溶液可以进一步包含异丙醇。消毒和抗微生物溶液可以进一步包含氯化钠水溶液电解的阳极电解液产物,并且阳极电解液产物包含消毒和抗微生物溶液的次氯酸。(A disinfecting and antimicrobial solution comprising: hypochlorous acid; silane quaternary ammonium ions or salts thereof; and water. Hypochlorous acid may be present in the solution at a concentration of 0.1 to 1000 ppm. The silane quaternary ammonium ion or salt thereof may be one or more of the following: 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion, 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium chloride. The silane quaternary ammonium ion or salt thereof may be 0.1 to 10% by weight of the solution. The disinfecting and antimicrobial solution may further comprise isopropyl alcohol. The disinfecting and antimicrobial solution may further comprise an anolyte product of the electrolysis of the aqueous sodium chloride solution, and the anolyte product comprises hypochlorous acid of the disinfecting and antimicrobial solution.)

1. A disinfecting and antimicrobial solution comprising:

hypochlorous acid;

silane quaternary ammonium ions or salts thereof; and

and (3) water.

2. The disinfecting and antimicrobial solution of claim 1,

the hypochlorous acid is present in the solution at a concentration of 0.1 to 1000 ppm.

3. The disinfecting and antimicrobial solution of claim 1,

the silane quaternary ammonium ion or salt thereof is one or more of the following:

3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion,

3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride,

3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and

3- (Trihydroxysilyl) propyldimethyloctadecyl ammonium chloride.

4. The disinfecting and antimicrobial solution of any one of claims 1-3,

the silane quaternary ammonium ion or salt thereof is 0.75 to 5 wt% of the solution.

5. The disinfecting and antimicrobial solution of any one of claims 1-3, further comprising:

and (3) isopropanol.

6. The disinfecting and antimicrobial solution of any one of claims 1-3, further comprising:

an anolyte product of an electrolysis of an aqueous sodium chloride solution, the anolyte product comprising the hypochlorous acid.

7. The disinfecting and antimicrobial solution of claim 6, further comprising:

a catholyte product of the aqueous sodium chloride electrolysis producing the anolyte product, the catholyte product comprising sodium hydroxide.

8. A disinfecting and antimicrobial solution comprising:

0.1 to 1000ppm hypochlorous acid;

0.1 to 10 wt% of a silane quaternary ammonium ion or salt thereof; and

and (3) water.

9. The disinfecting and antimicrobial solution of claim 8,

the silane quaternary ammonium ion or salt thereof is one or more of the following:

3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion,

3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride,

3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and

3- (Trihydroxysilyl) propyldimethyloctadecyl ammonium chloride.

10. The disinfecting and antimicrobial solution of any one of claims 8-9, further comprising:

and (3) isopropanol.

11. An antimicrobial solution comprising:

sodium hydroxide;

silane quaternary ammonium ions or salts thereof; and

and (3) water.

12. The antimicrobial solution according to claim 11, wherein the antimicrobial solution,

the silane quaternary ammonium ion or salt thereof is one or more of the following:

3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion,

3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride,

3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and

3- (Trihydroxysilyl) propyldimethyloctadecyl ammonium chloride.

13. The antimicrobial solution according to any one of claims 11 to 12,

the silane quaternary ammonium ion or salt thereof is 0.1 to 10 wt% of the solution.

14. The antimicrobial solution of any one of claims 11-12, further comprising:

and (3) isopropanol.

15. The antimicrobial solution of any one of claims 11-12, further comprising:

a catholyte product of an electrolysis of an aqueous sodium chloride solution, the catholyte product comprising the sodium hydroxide.

16. The antimicrobial solution of claim 15, further comprising:

an anolyte product of the electrolysis of the aqueous sodium chloride solution, the anolyte product comprising hypochlorous acid.

Background

The electrolysis of an aqueous solution of sodium chloride (sometimes referred to as an aqueous salt solution) produces hypochlorous acid (HOCl). More specifically, an electrolytic cell, typically having a membrane permeable to sodium and chloride ions, separates the anode and cathode. At the anode, hypochlorous acid, hydrochloric acid (HCl) and hypochlorite ions (ClO) are generated^-) And oxygen (O)₂) And chlorine (Cl)₂) A gas. The chlorine content is in equilibrium and the main chemical is a function of pH, with hypochlorous acid dominating at pH values between 2 and 7. At the cathode, an alkaline solution of sodium hydroxide (NaOH) and hydrogen gas (H) are generated₂) A gas. The acidic solution produced at the anode is sometimes referred to as "anolyte" or "acidic electrolyzed water". The alkaline solution produced at the cathode is sometimes referred to as "catholyte" or "alkaline electrolyzed water". The combination of both is sometimes referred to as "neutral electrolytic water".

Hypochlorous acid has been used as a germicide, disinfectant, and antimicrobial agent in a variety of applications. Exemplary applications of hypochlorous acid include disinfecting food processing surfaces and sterilizing medical equipment in hospitals. Hypochlorous acid kills microorganisms very rapidly by reacting irreversibly with membrane enzymes and structural proteins. A "catholyte" containing sodium hydroxide has been used as a cleaning agent.

However, the reactivity of hypochlorous acid poses a problem because hypochlorous acid does not act as a persistent or prophylactic antimicrobial agent. Similarly, the "anolyte" has a limited shelf life, in which the concentration of hypochlorous acid rapidly decreases over time.

Disclosure of Invention

The present disclosure solves this problem by combining a silane quaternary ammonium component with hypochlorous acid. The silane quaternary ammonium component imparts a persistent antimicrobial component to solutions containing hypochlorous acid. When the solution containing the silane quaternary ammonium component is applied to a surface, the silane quaternary ammonium component is caused to bind to the surface. The silane quaternary ammonium component does not deactivate through reaction in the same way as hypochlorous acid. Thus, the silane quaternary ammonium component provides a long lasting antimicrobial efficacy even if the hypochlorous acid has reacted and thus expired, or even if the concentration of hypochlorous acid in the solution has decreased. In a sense, the silane quaternary ammonium component provides ready antimicrobial functionality in the event that hypochlorous acid has reacted or the concentration in the solution has been reduced.

According to a first aspect of the present disclosure, a disinfecting and antimicrobial solution comprises: hypochlorous acid; silane quaternary ammonium ions or salts thereof; and water. In an embodiment, the hypochlorous acid is present in the solution at a concentration of 0.1 to 1000 ppm. In an embodiment, the hypochlorous acid is present in the solution at a concentration of 0.1 to 200 ppm. In an embodiment, the hypochlorous acid is present in the solution at a concentration of 200 to 1000 ppm.

In embodiments, the silane quaternary ammonium ion or salt thereof is one or more of the following: 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion, 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium chloride. In embodiments, the silane quaternary ammonium ion or salt thereof is 0.1 to 10 weight percent of the solution. In embodiments, the silane quaternary ammonium ion or salt thereof is 0.75 to 5 weight percent of the solution. In embodiments, the silane quaternary ammonium ion or salt thereof is 1.9 to 2.1 weight percent of the solution. In an embodiment, the disinfecting and antimicrobial solution further comprises isopropyl alcohol.

In an embodiment, the disinfecting and antimicrobial solution further comprises: an anolyte product of aqueous sodium chloride electrolysis, and the anolyte product comprising hypochlorous acid. In an embodiment, the disinfecting and antimicrobial solution further comprises: an aqueous sodium chloride solution producing an anolyte product electrolyzes the catholyte product, and the catholyte product comprises sodium hydroxide.

According to a second aspect of the present disclosure, a disinfecting and antimicrobial solution comprises: 0.1 to 1000ppm hypochlorous acid; 0.1 to 10 wt% of a silane quaternary ammonium ion or salt thereof; and water. In embodiments, the silane quaternary ammonium ion or salt thereof is one or more of the following: 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion, 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium chloride. In an embodiment, the disinfecting and antimicrobial solution further comprises isopropyl alcohol.

According to a third aspect of the present disclosure, an antimicrobial solution comprises: sodium hydroxide; silane quaternary ammonium ions or salts thereof; and water. In embodiments, the silane quaternary ammonium ion or salt thereof is one or more of the following: 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion, 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium chloride. In embodiments, the silane quaternary ammonium ion or salt thereof is 0.1 to 10 weight percent of the solution. In an embodiment, the antimicrobial solution further comprises isopropyl alcohol. In embodiments, the antimicrobial solution further comprises: a catholyte product of an aqueous sodium chloride solution electrolysis, the catholyte product comprising sodium hydroxide. In embodiments, the antimicrobial solution further comprises: an anolyte product of electrolysis of aqueous sodium chloride solution, the anolyte product comprising hypochlorous acid.

These and other features, advantages, and objects of the present disclosure will be further understood and appreciated by those skilled in the art by reference to the following specification and claims.

Detailed Description

For the purposes of this description, it is to be understood that the specific devices and processes described in the following specification are simply exemplary embodiments of the inventive concepts defined in the appended claims. Thus, physical features associated with the embodiments disclosed herein are not to be considered as limiting, unless the claims expressly state otherwise.

A disinfecting and antimicrobial solution is described herein. The disinfecting and antimicrobial solution includes hypochlorous acid, silane quaternary ammonium ions or salts thereof, and water.

In the examples, hypochlorous acid is the product of the electrolysis of aqueous sodium chloride solution. In embodiments, the hypochlorous acid is present in the solution at a concentration of 0.1 to 1000ppm, such as a concentration of 0.1 to 200ppm, or a concentration of 200 to 1000 ppm.

In embodiments, the silane quaternary ammonium ion or salt thereof is one or more of the following: 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion, 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium chloride. In embodiments, the silane quaternary ammonium ion or salt thereof is 0.1 to 10 weight percent of the solution, such as 0.75 to 5 weight percent of the solution, such as 1.9 to 2.1 weight percent of the solution.

In an embodiment, the disinfecting and antimicrobial solution further comprises isopropyl alcohol.

In particular embodiments, the disinfecting and antimicrobial solution comprises 0.1 to 1000ppm hypochlorous acid, 0.1 to 10 weight percent silane quaternary ammonium ion or salt thereof, and water. The solution may further comprise isopropanol.

In an embodiment, hypochlorous acid is a component of the anolyte for the electrolysis of aqueous sodium chloride solution. In such embodiments, the anolyte solution containing hypochlorous acid is combined with a solution containing silane quaternary ammonium ions or salts thereof. In one variation, the catholyte product of the electrolysis of aqueous sodium chloride solution is also added to the disinfecting and antimicrobial solution, thereby providing sodium hydroxide to the aqueous solution.

The addition of silane quaternary ammonium ions or salts thereof provides a durable antimicrobial activity that is retained after hypochlorous acid has been deactivated by reaction or other reasons. The silane groups of the silane quaternary ammonium ion bond to the surface to which it is applied. When a microbial cell is exposed to silane quaternary ammonium ions, several mechanisms are thought to lead to death of the microbial cell — (1) the quaternary ammonium group causes an ionic imbalance in the cell; or (2) long alkyl chains penetrate into and rupture the cells. Unlike hypochlorous acid, silane quaternary ammonium ions destroy microbial cells without consuming silane quaternary ammonium ions. Silane quaternary ammonium ions are free to destroy more microbial cells. Thus, even after the hypochlorous acid has reacted, the silane quaternary ammonium ion remains bound to the surface to which it is applied to continue to provide antimicrobial properties.

In another aspect of the disclosure, the antimicrobial solution comprises sodium hydroxide, silane quaternary ammonium ion or salt thereof, and water. The silane quaternary ammonium ion or salt thereof is one or more of the following: 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium ion, 3- (trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium ion, and 3- (trihydroxysilyl) propyldimethyloctadecyl ammonium chloride. The silane quaternary ammonium ion or salt thereof is 0.1 to 10% by weight of the solution.

In an embodiment, sodium hydroxide is a component of a catholyte product of aqueous sodium chloride electrolysis, and the catholyte product is combined with a silane quaternary ammonium ion or salt thereof. In an embodiment, the antimicrobial solution further comprises an anolyte product of electrolysis of the aqueous sodium chloride solution, and the anolyte product comprises hypochlorous acid.

It is to be understood that variations and modifications can be made on the aforementioned structure without departing from the concepts of the present disclosure, and further it is to be understood that such concepts are intended to be covered by the following claims unless these claims by their language expressly state otherwise.