阅读说明：本技术 一种三氟甲烷硫醇银(i)的合成方法 (Synthesis method of silver (I) trifluoromethanesulfonate ) 是由 史大永 田阳 许凤 于 2021-02-25 设计创作，主要内容包括：本发明属于有机化合物合成技术领域,涉及一种三氟甲烷硫醇银(I)的合成方法。一种三氟甲烷硫醇银(I)(CAS号：811-68-7)的合成方法,以氟化银为原料,采用三氟甲硫酯作为三氟甲硫基来源,合成三氟甲烷硫醇银(I)。本发明以三氟甲硫酯作为三氟甲硫基来源,在溶剂中与氟化银反应生成三氟甲烷硫醇银(I),分离提纯后得到三氟甲烷硫醇银(I)成品。本发明所述的三氟甲烷硫醇银(I)的合成方法,原材料易得、反应试剂易制备且价格低廉,显著降低了三氟甲烷硫醇银(I)的合成成本,合成条件温和,操作简便安全,利于工业化生产；银原子利用率高、绿色环保。(The invention belongs to the technical field of organic compound synthesis, and relates to a method for synthesizing silver (I) trifluoromethanesulfonate. A method for synthesizing silver (I) trifluoromethanesulfonate (CAS number: 811-68-7) uses silver fluoride as a raw material and trifluoromethylthio ester as a trifluoromethylthio source to synthesize the silver (I) trifluoromethanesulfonate. The method takes trifluoromethylthioester as a trifluoromethylthio source, and reacts with silver fluoride in a solvent to generate the silver (I) trifluoromethanesulfonate, and the finished product of the silver (I) trifluoromethanesulfonate is obtained after separation and purification. The synthesis method of the silver (I) trifluoromethanesulfonate has the advantages of easily obtained raw materials, easily prepared reaction reagents and low price, obviously reduces the synthesis cost of the silver (I) trifluoromethanesulfonate, has mild synthesis conditions, is simple and safe to operate, and is beneficial to industrial production; high utilization rate of silver atoms and environmental protection.)

1. A method for synthesizing silver (I) trifluoromethanesulfonate (CAS number: 811-68-7) is characterized in that silver fluoride is used as a raw material, and trifluoromethylthio ester is used as a trifluoromethylthio source to synthesize the silver (I) trifluoromethanesulfonate.

2. The method for synthesizing silver (I) trifluoromethanesulfonate according to claim 1, wherein the reaction equation is:

in the formula (3), R is an optional substituent;

the synthesis process of the compound shown in the formula (1) comprises the following steps: dissolving a compound shown as a formula (2) and a compound shown as a formula (3) in a solvent, reacting for a certain time at a specific temperature to generate a compound shown as a formula (1);

the solvent is an organic solvent;

in the reaction system, the molar ratio of the compound shown in the formula (2) to the compound shown in the formula (3) is 1 (1-10);

the reaction temperature is 0-50 ℃, and the reaction time is 0.5-72 h.

3. The method for synthesizing silver (I) trifluoromethanesulfonate according to claim 2, wherein R in formula (3) is selected from aryl, alkyl, alkenyl, alkynyl, halogen, alkoxy, phenoxy, alkylthio, phenothio, H, NO₂And CN group.

4. The method for synthesizing silver (I) trifluoromethanesulfonate according to any one of claims 2 to 3, wherein the solvent is any one of 1, 2-dichloroethane, dichloromethane, acetonitrile, 1, 4-dioxane, benzene, toluene, xylene, benzotrifluoride, N-dimethylformamide, N-dimethylacetamide, dimethylsulfoxide, tetrahydrofuran, methanol, ethanol, isopropanol, hexafluoroisopropanol, and diethyl ether.

Technical Field

The invention belongs to the technical field of organic compound synthesis, and relates to a method for synthesizing silver (I) trifluoromethanesulfonate.

Background

Fluorine atoms play an important role in modern drug design and synthesis (Liu X, Xu C, Wang M, et al. trifluoromethyl silanes: nucleophillic trifluoromethyl and beyond [ J]Chem Rev, 2015, 115(2): 683-730.), statistically, 15% to 20% of modern drugs contain fluorine-containing groups (Hui R, Zhang S, Tan Z, et al, Research Progress of fluorination with Sodium trifluoromethane and refining [ J ]]China J Org Chem (organic chemistry), 2017, 37 (12): 3060-3075). The presence of fluorine-containing groups helps to increase the lipophilicity and metabolic stability of the drug molecule (Yang B, Xu XH, Qing FL. chip-mediated radial 1,2-bis (trifluoromethyla)tion) of alkenes with sodium trifluoromethanesulfinate[J]Org Lett, 2015, 17(8): 1906-. Meanwhile, trifluoromethylthio (-SCF3) is one of the most lipophilic fluorine-containing functional groups (Hansch parameter pi)_R= 1.44), the introduction of the group into the medicine can obviously change the liposolubility of the medicine, and improve the bioavailability and the biomembrane permeability of the medicine. (Glenadiel Q, Tlili A, Billard T. Metal-Free Direct Dehydroalkylation of alcohol visa the reaction of trifluomethyl amides [ J]. Eur J Org Chem, 2016(11):1955-1957.）

Silver (I) trifluoromethanesulfonate is an important nucleophilic trifluoromethanesulfonylation reagent and plays an important role in the trifluoromethanesulfonylation reaction, but the original synthesis method has low utilization rate of silver atoms and generates more silver sulfide byproducts, (Zheng HD, Huang YJ, Weng ZQ. Recent Advances in microfluidization reaction using nuclear microfluidization Reagents [ J ]. Tetrahedron Letters, 2016, 57(13): 1397-1409; Zhang PP, Lu L, Shen, QL. Recent Progress on fluorescence methylation Reagents and Methods [ J ]. AcChita m. Sinica, 2017, 75, 744-769), thereby causing higher synthesis cost and more waste.

Therefore, the development of a new method for synthesizing the silver (I) trifluoromethanesulfonate to replace the existing synthesis process has important significance for realizing large-scale industrial production of the silver (I) trifluoromethanesulfonate.

Disclosure of Invention

The invention aims to provide a novel high-efficiency synthesis method of silver (I) trifluoromethanesulfonate aiming at the defects and shortcomings of the existing synthesis method, and the method has the advantages of easily obtained synthesis raw materials and a trifluoromethanesulfonyl sulfate reagent, low cost, mild conditions, less waste, simple synthesis process and the like.

In order to achieve the purpose, the invention adopts the technical scheme that: a method for synthesizing silver (I) trifluoromethanesulfonate (CAS number: 811-68-7) comprises the steps of synthesizing the silver (I) trifluoromethanesulfonate by taking silver fluoride as a raw material and adopting trifluoromethylthio ester as a trifluoromethylthio source.

In a preferred embodiment of the present invention, the reaction equation for synthesizing silver (I) trifluoromethanesulfonate is:

in the formula (3), R is an optional substituent;

the synthesis process of the compound shown in the formula (1) comprises the following steps: dissolving a compound shown as a formula (2) and a compound shown as a formula (3) in a solvent, reacting for a certain time at a specific temperature to generate a compound shown as a formula (1);

the solvent is an organic solvent;

in the reaction system, the molar ratio of the compound shown in the formula (2) to the compound shown in the formula (3) is 1 (1-10);

the reaction temperature is 0-50 ℃, and the reaction time is 0.5-72 h.

Further preferably, in formula (3), R is selected from aryl, alkyl, alkenyl, alkynyl, halogen, alkoxy, phenoxy, alkylthio, phenothio, H, NO₂And CN group.

Further preferably, the solvent is any one of 1, 2-dichloroethane, dichloromethane, acetonitrile, 1, 4-dioxane, benzene, toluene, xylene, trifluorotoluene, N-dimethylformamide, N-dimethylacetamide, dimethylsulfoxide, tetrahydrofuran, methanol, ethanol, isopropanol, hexafluoroisopropanol, and diethyl ether.

Compared with the existing synthesis method, the synthesis method of the silver (I) trifluoromethanesulfonate has the following beneficial effects:

(1) the trifluoro-methyl-thionine reaction reagent adopted by the invention is commercially available and easy to synthesize, the synthesis cost of the trifluoro-methyl-mercaptan silver (I) is obviously reduced, and the industrial production is facilitated;

(2) the synthesis method has mild conditions, can be carried out at normal temperature and normal pressure, and has low requirement on required equipment;

(3) simple and safe operation, mild reaction conditions, less waste and environmental protection.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Examples 1 to 3 mainly illustrate the wide applicability of the trifluoromethylthioesters used in the process of the present invention, and examples 4 to 7 mainly illustrate that silver (I) trifluoromethanesulfonate can be obtained even when the conditions such as solvent, reaction temperature, reaction time and the like are changed.

Example 1: in this example, silver (I) trifluoromethanesulfonate was synthesized by reacting silver fluoride with p-phenylbenzoic acid trifluoromethylthioester (3 a) (S- (trifluoromethylphenyl) [1,1' -biphenyl ] -4-carbothioate)

The reaction equation is:

the synthesis steps and the process are as follows: silver fluoride (0.4 mmol, 51 mg) and p-benzylacid trifluoromethylthioester 3a (1.0 mmol, 282 mg) are added into a 10 mL reaction tube provided with a magnetic stirrer, 4.0mL dimethyl sulfoxide is added, the reaction tube is fixed on the magnetic stirrer, the reaction is carried out for 24 hours under 35 ℃ oil bath, and the target product silver (I) trifluoromethanesulfonate is obtained through separation and purification, wherein the yield is 67.8%.

Example 2: in this example, silver (I) trifluoromethanesulfonate was synthesized by reacting silver fluoride with trifluoromethanesulfonic acid (3 b) (S- (trifluoromethylthio) dodecanethioate)

The reaction equation is:

the synthesis steps and the process are as follows: silver fluoride (0.5 mmol, 63.5 mg), trifluromethyl dodecanoate thioester 3b (2.0 mmol, 568mg) and then 4.0mL of 1.4-dioxane were added to a 10 mL reaction tube equipped with a magnetic stirrer; fixing the reaction tube on a magnetic stirrer, reacting at room temperature for 18 hours, separating and purifying to obtain the target product silver trifluoromethanesulfonate (I), wherein the yield is 47.7%.

Example 3: in this example, silver (I) trifluoromethanesulfonate was synthesized by reacting silver fluoride with p-trifluoromethylbenzoic acid trifluoromethanesulfonyl (3 c) (S- (trifluoromethylphenyl) 4- (trifluoromethylphenyl) benzothioate)

The reaction equation is:

the synthesis steps and the process are as follows: adding silver fluoride (1 mmol, 127 mg) and p-trifluoromethylbenzoic acid trifluoromethylthioester 3c (1.0 mmol, 274 mg) into a 10 mL reaction tube provided with a magnetic stirrer, then adding 3.0 mL acetonitrile, fixing the reaction tube on the magnetic stirrer, reacting for 36 hours at 15 ℃, and separating and purifying to obtain the target product silver (I) trifluoromethanesulfonate with the yield of 72.5%.

Example 4: in this example, silver (I) trifluoromethanesulfonate was synthesized by reacting silver fluoride with p-trifluoromethylbenzoic acid trifluoromethanesulfonyl (3 c) (S- (trifluoromethylphenyl) 4- (trifluoromethylphenyl) benzothioate)

The reaction equation is:

the synthesis steps and the process are as follows: to a 10 mL reaction tube equipped with a magnetic stirrer was added silver fluoride (0.6 mmol, 76mg), p-trifluoromethylbenzoic acid trifluoromethylthioester 3c (3.0 mmol, 822mg), and then 4.0mL of trifluorotoluene; fixing the reaction tube on a magnetic stirrer, reacting for 10 hours at 20 ℃, separating and purifying to obtain the target product silver trifluoromethanesulfonate (I) with the yield of 78.4%.

Example 5: in this example, silver (I) trifluoromethanesulfonate was synthesized by reacting silver fluoride with p-trifluoromethylbenzoic acid trifluoromethanesulfonyl (3 c) (S- (trifluoromethylphenyl) 4- (trifluoromethylphenyl) benzothioate)

The reaction equation is:

the synthesis steps and the process are as follows: to a 10 mL reaction tube equipped with a magnetic stirrer was added silver fluoride (0.6 mmol, 76mg), p-trifluoromethylbenzoic acid trifluoromethylthioester 3c (3.0 mmol, 822mg), and then 4.0mL of diethyl ether; fixing the reaction tube on a magnetic stirrer, reacting at 10 ℃ for 24 hours, separating and purifying to obtain the target product silver trifluoromethanesulfonate (I), wherein the yield is 25.3%.

Example 6: in this example, silver (I) trifluoromethanesulfonate was synthesized by reacting silver fluoride with p-trifluoromethylbenzoic acid trifluoromethanesulfonyl (3 c) (S- (trifluoromethylphenyl) 4- (trifluoromethylphenyl) benzothioate)

The reaction equation is:

the synthesis steps and the process are as follows: adding silver fluoride (0.6 mmol, 76mg) and p-trifluoromethyl thioester 3c (3.0 mmol, 822mg) into a 10 mL reaction tube provided with a magnetic stirrer, then adding 4.0mL toluene, fixing the reaction tube on the magnetic stirrer, reacting for 10 hours at 50 ℃, and separating and purifying to obtain the target product silver trifluoromethanesulfonate (I) with the yield of 43.4%.

Example 7: in this example, silver (I) trifluoromethanesulfonate was synthesized by reacting silver fluoride with p-trifluoromethylbenzoic acid trifluoromethanesulfonyl (3 c) (S- (trifluoromethylphenyl) 4- (trifluoromethylphenyl) benzothioate)

The reaction equation is:

the synthesis steps and the process are as follows: silver fluoride (0.6 mmol, 76mg) and p-trifluoromethyl thioester (3.0 mmol, 822mg) were added to a 10 mL reaction tube equipped with a magnetic stirrer, 4.0mL of dichloromethane was added, the reaction tube was fixed to the magnetic stirrer, and the reaction was carried out at 15 ℃ for 36 hours, followed by isolation and purification to obtain the target product silver trifluoromethanesulfonate (I) with a yield of 48.5%.

According to the method, the cheap and easily-obtained trifluoromethylthio ester is used as a trifluoromethylthio source to synthesize the silver (I) trifluoromethanesulfonate, so that the use amount of silver atoms can be obviously reduced, and the waste emission is reduced. Table 1 summarizes a comparison of the methods of the present invention with existing mainstream methods.

TABLE 1 comparison of the Process used according to the invention with the existing Process