阅读说明：本技术 一种用于处理驱蚊织物的新型杀虫剂整理液及使用方法 (Novel insecticide finishing liquid for treating mosquito-repellent fabric and using method ) 是由 莫凌志 尹青 牛维良 于 2020-12-18 设计创作，主要内容包括：本发明提供了一种用于处理驱蚊织物的新型杀虫剂整理液,创新的加入了新型杀虫剂溴虫腈,溴虫腈属于吡咯杀虫剂。溴虫腈主要用于白蚁防治和农作物各种害虫的防治,它通过靶向破坏昆虫线粒体中的氧化途径,从而破坏ATP产生来发挥作用,由于溴虫腈与现有的公共卫生杀虫剂之间没有交叉抗性,其新型的作用模式使其成为针对对多种药有抗性的疟疾病媒的合适候选杀虫剂,溴虫腈和顺式氯氰菊酯在蚊帐上的混合物已被证明对拟除虫菊酯抗性蚊子有刺激性驱避和强杀虫活性。(The invention provides a novel insecticide finishing liquid for treating mosquito-repellent fabrics, which is innovatively added with a novel insecticide chlorfenapyr, wherein the chlorfenapyr belongs to pyrrole insecticides. Bromothalonil is mainly used for termite control and control of various pests of crops, and it acts by destroying ATP production by targeted destruction of oxidative pathways in the mitochondria of insects, and since bromothalonil has no cross-resistance with existing public health insecticides, its novel mode of action makes it a suitable candidate for malaria vectors resistant to various drugs, and mixtures of bromothalonil and cis-cypermethrin on mosquito nets have been shown to have irritant repellency and strong insecticidal activity against pyrethroid resistant mosquitoes.)

1. A novel insecticide finishing liquid for treating mosquito repellent fabrics is characterized by comprising the following components in percentage by mass: the effective components are 1 to 30 percent of pyrethroid suspending agent: 1% -15%; the effective components are 1 to 30 percent of chlorfenapyr suspending agent: 2% -30%; binder with a solid content of 10-50%: 4% -50%; preservative: 1% -2%; the balance of water.

2. A novel insecticide finish for treating mosquito repellent fabrics according to claim 1 wherein said pyrethroid is one of the insecticides alpha-cypermethrin, cyfluthrin, cypermethrin, permethrin or deltamethrin.

3. A novel insecticide finish for treating mosquito repellent fabrics according to claim 2 wherein said pyrethroid is cis-cypermethrin.

4. A novel insecticide finish for treating mosquito repellent fabrics according to claim 1 wherein said preservative is dimethyl fumarate or cason.

5. The novel insecticide finishing liquid for treating mosquito repellent fabrics according to claim 1, wherein the adhesive is one or two of aqueous polyurethane emulsion, aqueous polyacrylate emulsion or aqueous ethyl acetate emulsion.

6. The novel insecticide finishing liquid for treating mosquito-repellent fabrics according to claim 5, wherein when two of aqueous polyurethane emulsion, aqueous polyacrylate emulsion or aqueous ethyl acetate emulsion are selected as the adhesive, the mass ratio of the two is 1: 1.

7. A use method of a novel insecticide finishing liquid for treating mosquito repellent fabrics comprises the following steps:

1) firstly, finishing the fabric by padding equipment to uniformly spread the fabric;

2) putting the finishing liquid into a liquid tank, and then fully soaking the fabric in the finishing liquid through the liquid tank;

3) the fabric fully soaked in the finishing liquor is rolled, and the pressure of the roller is adjusted to control the liquor carrying rate of the fabric to be 60-110%; then entering a drying and setting machine, wherein the drying and setting temperature is 60-120 ℃;

4) the fabric product with mosquito repelling effect is obtained.

8. The use method of the novel insecticide finishing liquid for treating mosquito repellent fabrics as claimed in claim 7, wherein the obtained fabric product with mosquito repellent effect contains 50-270 mg of pyrethroid insecticide active ingredients per square meter of fabrics, 450 mg of chlorfenapyr active ingredients per square meter of fabrics, and the mass content ratio of the chlorfenapyr to the pyrethroids is 1-10: 1.

9. The use method of the novel insecticide finishing liquid for treating the mosquito repellent fabric is characterized in that the mass content ratio of the chlorfenapyr to the pyrethroid is most preferably 2: 1.

10. Use of a novel insecticide finish for treating mosquito repellent fabrics according to claim 7, wherein the fabric material is preferably polyethylene terephthalate (PET).

Technical Field

The invention relates to the field of sanitary insecticides, in particular to a novel insecticide finishing liquid for treating mosquito-repellent fabrics and a using method thereof.

Background

Malaria is an infectious disease caused by the parasite of malaria, which is one of the major causes of death among humans worldwide, via malaria mosquito bites or transfusions into the blood of those with malaria parasites. The world malaria report published by the world health organization 2018 shows that: in 2017, an estimated 2.19 million cases of malaria were worldwide, while in 2010 there were 2.39 million cases and in 2016 there were 2.17 million cases). The majority of malaria cases in 2017 occurred in the african region of the world wide facility (2 billion or 92%), followed by the southeast asia region of the world wide facility (5%) and the middle east sea region of the world wide facility (2%) during the period between 2010 and 2017, with a global malaria incidence declining from 72 to 59 per 1000 risk populations. Although this figure was 18% less than contemporary, in 2017, an estimated 43.5 million people died from malaria globally, compared to 45.1 million people in 2016 and 60.7 million people in 2010. The prevention of malaria is a very slow task for humans.

In the prevention and control of malaria, personal protective measures against mosquito bites are the first line of defense against disease and are also effective measures against malaria. At present, two kinds of relatively mature mosquito prevention methods are mainly applied. The first method is a method for repelling or killing mosquitoes in the environment, and the method is simple and convenient to use and economical, but the effect is not lasting and needs to be used frequently. And the smoke or medicament released by the mosquito coil or the insecticidal aerosol can cause certain damage to human bodies, so the mosquito coil or the insecticidal aerosol is not suitable for being frequently used. The second is mosquito repellent fabric treated with pesticide, which is used to treat fabric contacting human body for lasting mosquito repelling effect. The method is simple to operate, convenient to use and mature in technical process, and long-time production practices prove that the mosquito-proof agent has a good mosquito-proof effect and is non-toxic and harmless to human bodies.

The mosquito-proof mosquito net is a textile which is processed and finished after long-term use, the mosquito net with long-term use efficacy is called a long-acting mosquito-proof mosquito net, and the methods widely recommended by WHO at present for spreading the diseases of the sand flies and the mosquitoes at night are the long-acting mosquito-proof mosquito net, materials treated by insecticide and the like. The aims of preventing and treating disease transmission and protecting human health are achieved by preparing and using the mosquito net treated by the insecticide.

Currently, pyrethroids, one of the main compounds of long-acting mosquito nets, are highly toxic when used alone, and with the increasing use time of this organically synthesized insecticide, mosquitoes and flies develop various degrees of resistance to this class of insecticide (gashiwu et al, china media biology and control journal, 2004,15(2), 105).

Chinese patent (publication No. CN 1099825) discloses a mosquito-proof, mosquito-killing and sterilizing fabric finishing liquid, a synergist is added in a formula, and after a liquid medicine consisting of a mosquito repellent, a mosquito killer, a bactericide, a synergist and the like is soaked and dried, the obtained fabric has mosquito-proof, mosquito-killing and sterilizing functions, but the formula serving as the mosquito-proof finishing liquid has the defect that the lasting pesticide effect time is only half a year and the lasting pesticide effect time is short. While only appropriate washing and sun exposure can be performed.

Chinese patent publication No. CN 1664227A discloses a fabric finishing liquid for repelling and killing mosquitoes, which comprises insecticide, repellent, adhesive and cross-linking agent, and the fabric product finished by the fabric finishing liquid has strong capability of repelling and killing mosquitoes and is resistant to water washing, but the mosquitoes can generate drug resistance to the insecticide pyrethroid in the fabric finishing liquid along with the increase of the using time.

Chinese patent publication No. CN 102480970a discloses an insecticidal net material for protecting human and animals, which is made of chlorfenapyr (chlorenapyr) and one or more pyrethroids selected from cis-cypermethrin (alpha-cypermethrin), deltamethrin (deltamethrin), permethrin (permethrin) and lambda-cyhalothrin (lambda-cyhalothrin). However, the patent does not describe the process used to distribute the insecticide uniformly throughout the insecticidal material. The mere use of impregnation results in uneven distribution of the insecticide in the insecticidal material, resulting in ineffective insecticidal effect.

Namely, the prior art has the defects that the resistance of mosquitoes is increased due to the use of a single pyrethroid insecticide, the prepared mosquito killing fabric cannot be used after long-term washing, the lasting time is short, and the washing resistance effect is poor. Meanwhile, due to poor process, the pesticide is easily distributed unevenly, and the best biological pesticide effect cannot be achieved.

Disclosure of Invention

According to the technical problems, the invention provides a novel insecticide finishing liquid for treating mosquito repellent fabrics, which comprises the following components in percentage by mass: the effective components are 1 to 30 percent of pyrethroid suspending agent: 1% -15%; the effective components are 1 to 30 percent of chlorfenapyr suspending agent: 2% -30%; binder with a solid content of 10-50%: 4% -50%; preservative: 1% -2%; the balance of water.

The pyrethroid is one of cis-cypermethrin, cyfluthrin, cypermethrin, permethrin or deltamethrin insecticides.

The pyrethroid is cis-cypermethrin.

The preservative is dimethyl fumarate or cason.

The adhesive is one or two of water-based polyurethane emulsion, water-based polyacrylate emulsion or water-based acetic acid ethyl ester emulsion.

When two of waterborne polyurethane emulsion, waterborne polyacrylate emulsion or waterborne ethyl acetate emulsion are selected as the adhesive, the mass ratio of the two is 1: 1.

A use method of a novel insecticide finishing liquid for treating mosquito repellent fabrics comprises the following steps:

1) firstly, finishing the fabric by padding equipment to uniformly spread the fabric;

2) putting the finishing liquid into a liquid tank, and then fully soaking the fabric in the finishing liquid through the liquid tank;

3) the fabric fully soaked in the finishing liquor is rolled, and the pressure of the roller is adjusted to control the liquor carrying rate of the fabric to be 60-110%; then entering a drying and setting machine, wherein the drying and setting temperature is 60-120 ℃;

4) the fabric product with mosquito repelling effect is obtained.

The obtained fabric product with the mosquito repellent effect contains 50-270 mg of pyrethroid insecticide active ingredients per square meter of fabric, and 450 mg of chlorfenapyr active ingredients per square meter of fabric, wherein the mass content ratio of the chlorfenapyr to the pyrethroid is 1-10: 1.

The mass content ratio of the chlorfenapyr to the pyrethroid is most preferably 2: 1.

The textile material is preferably polyethylene terephthalate (PET).

The invention has the beneficial effects that:

1. compared with pyrethrin single agents, the mosquito repellent fabric finishing liquid has obvious synergy to mosquitoes, solves the problem of resistance, obviously improves the control effect, and has the advantages that chlorfenapyr can destroy the oxidation path in the mitochondria of insects in a targeted mode, so that ATP is destroyed to play a role, and the chlorfenapyr does not have cross resistance with the existing public health insecticide, so that the chlorfenapyr becomes a suitable candidate insecticide for mosquitoes with resistance to various drugs in a novel mode. Mixtures of chlorfenapyr and cis-cypermethrin on mosquito nets have been shown to have an irritant repellent and strong insecticidal activity against pyrethroid resistant mosquitoes. Is an important way for solving the problem of the resistance of the pyrethrins;

2. the mosquito-repellent fabric can be obtained by directly carrying out impregnation, rolling and drying treatment, and the production process is simple in flow, easy to operate and capable of realizing industrial mass production. The content of the active substance of the obtained mosquito repellent fabric is uniformly distributed;

3. the fabric finishing liquid has the advantages of long-acting washing fastness, and the formula of the fabric finishing liquid comprises: insecticides, synergists, binders, cross-linking agents, preservatives and water. The fabric finishing liquid composed of the mixed liquid is used for finishing the fabric. Experiments show that after the fabric product is washed for 20 times by WHO standard (the washing program is a standard program recommended by the world health organization), the washing resistance index of the pesticide can still reach 80-98%, and the biological test can also reach the standard requirement specified by WHO.

Drawings

FIG. 1 is a liquid chromatogram of cis-cypermethrin according to the invention;

FIG. 2 is a liquid chromatogram of chlorfenapyr according to the present invention;

FIG. 3 is a graph showing knockdown and lethality rates for different mosquito species of the present invention;

FIG. 4 shows knockdown and lethality rates for different mosquito species of the present invention.

As shown in the figure:

Detailed Description

Example 1:

preparing a fabric finishing liquid, wherein the formula comprises the following components:

uniformly mixing the raw materials in a liquid preparation tank to obtain a mosquito repelling and killing finishing liquid;

manufacturing a mosquito repelling and killing fabric:

fabric: 100 percent of 100 denier terylene mosquito net cloth with the gram weight of 36 g/square meter;

putting the obtained fabric finishing liquid and the fabric to be finished into a setting machine with a padder; adopting a one-step method to manufacture a mosquito-repellent fabric product; the method comprises the steps of finishing the fabric by padding equipment to uniformly spread the fabric, fully soaking the fabric in finishing liquid by a liquid tank, rolling the fabric fully soaked in the finishing liquid by a roller, adjusting the pressure of a compression roller to enable the liquid carrying rate of the fabric to be 70%, and finally drying the fabric in a dryer at the drying temperature of 100 ℃ and the vehicle speed of 50 m/min to obtain the water-resistant mosquito repelling and killing terylene mosquito net fabric industrially.

Finishing effect:

after finishing: the effective contents of the cis-cypermethrin (measured by liquid chromatography, as shown in figure 1, the same below) and the chlorfenapyr (measured by liquid chromatography, as shown in figure 2, the same below) on the fabric are 100 mg/square meter of fabric and 200 mg/square meter of fabric;

(4) biological tests (following the standard procedures recommended by WHO) effect:

biological effect after washing:

after 20 WHO standard water washes (wash procedure according to WHO recommended standard procedure):

the effective content of the cis-cypermethrin on the fabric is as follows: 40 mg/square meter of fabric, the wash index was 95%.

The effective content of the chlorfenapyr is as follows: 64 mg/square meter of fabric has a wash resistance index of 94%.

After 20 WHO standard washes (wash procedure according to WHO recommended standard procedure),

60 minute knockdown rate for sensitive aedes: 100 percent

The 24 hour mortality rate was: 99 percent

60 minute knockdown rate for susceptible anopheles mosquitoes: 100 percent

The 24 hour mortality rate was: 99 percent

60 minute knockdown rate against resistant anopheles mosquito: 98 percent of

The 24 hour mortality rate was: 92 percent of

The knockdown rate and the lethality rate for different mosquito species are shown in figure 3, the knockdown rate in 60 minutes reaches more than 90%, and the lethality rate reaches more than 80%. Meets the standards specified by WHO. Meanwhile, as can be seen from the figure, the prepared mosquito repellent fabric can also have the effect on the resistant anopheles mosquitoes.

Example 2:

preparing a fabric finishing liquid, wherein the formula comprises the following components:

uniformly mixing the raw materials in a liquid preparation tank to obtain a mosquito repelling and killing finishing liquid;

manufacturing a mosquito repelling and killing fabric:

fabric: 100 percent of 100 denier terylene mosquito net cloth with the gram weight of 36 g/square meter;

putting the obtained fabric finishing liquid and the fabric to be finished into a setting machine with a padder; adopting a one-step method to manufacture a mosquito-repellent fabric product; the method comprises the steps of finishing the fabric by padding equipment to uniformly spread the fabric, fully soaking the fabric in finishing liquid by a liquid tank, rolling the fabric fully soaked in the finishing liquid by a roller, adjusting the pressure of a compression roller to enable the liquid carrying rate of the fabric to be 80%, and finally drying the fabric in a dryer at the drying temperature of 120 ℃ and the vehicle speed of 60 m/min to obtain the water-resistant mosquito repelling and killing terylene mosquito net fabric industrially.

Finishing effect:

after finishing: the effective content of the cis-cypermethrin (determined by liquid chromatography and the same below) and the chlorfenapyr (determined by liquid chromatography and the same below) on the fabric is 200 mg/square meter of fabric and 400 mg/square meter of fabric;

(4) biological tests (following the standard procedures recommended by WHO) effect:

biological effect after washing:

after 20 WHO standard water washes (wash procedure according to WHO recommended standard procedure):

the effective content of the cis-cypermethrin on the fabric is as follows: 84 mg/square meter of fabric, the wash index was 96%.

The effective content of the chlorfenapyr is as follows: 120 mg/square meter fabric with a wash index of 94%.

After 20 WHO standard washes (wash procedure according to WHO recommended standard procedure),

60 minute knockdown rate for susceptible anopheles mosquitoes: 100 percent

The 24 hour mortality rate was: 95 percent

60 minute knockdown rate against resistant anopheles mosquito: 98 percent of

The 24 hour mortality rate was: 90 percent of

The knockdown rate and the lethality rate for different mosquito species are shown in the fourth graph, the knockdown rate in 60 minutes reaches more than 90%, and the lethality rate reaches more than 80%. Meets the standards specified by WHO. Meanwhile, as can be seen from the attached figure 4, the prepared mosquito repellent fabric has the same effect on the resistant anopheles mosquitoes.

The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. While the invention has been described with respect to the above embodiments, it will be understood by those skilled in the art that the invention is not limited to the above embodiments, which are described in the specification and illustrated only to illustrate the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.