阅读说明：本技术 微型化与智能型的尿液感测系统 (Miniaturized and intelligent urine sensing system ) 是由 李顺裕 陈儒逸 谢孟达 林家裕 林于缙 邱鼎翔 于 2019-11-15 设计创作，主要内容包括：本发明提供一种微型化与智能型的尿液感测系统,微型化与智能型的尿液感测系统包括：一尿液传感器试片,具有微流道结构及多通道结构,各多通道结构分别设有一非生物型传感器或一生物型传感器,于微流道结构内设置多个微帮浦、微混合器与用以收容废液的废液槽与用以收容电解质溶液的电解槽；以及一尿液信号检测装置,具有一电源供应单元、一数字控制器、一无线传送接收电路、一触发处理单元以及一感测信号处理单元,电源供应单元、数字控制器、无线传送接收电路、触发处理单元以及感测处理单元整合为一系统单芯片。本发明能让用户不受时间与地点的拘束,定期的检测尿液,透过持续的检测,以进行心脏疾病或糖尿病与肾脏疾病间的风险指数的评估。(The invention provides a miniaturized and intelligent urine sensing system, which comprises: a urine sensor test piece, which has a micro-channel structure and multi-channel structures, wherein each multi-channel structure is respectively provided with a non-biological sensor or a biological sensor, and a plurality of micro pumps, micro mixers, a waste liquid tank for containing waste liquid and an electrolytic tank for containing electrolyte solution are arranged in the micro-channel structure; and a urine signal detection device, which is provided with a power supply unit, a digital controller, a wireless transmitting and receiving circuit, a trigger processing unit and a sensing signal processing unit, wherein the power supply unit, the digital controller, the wireless transmitting and receiving circuit, the trigger processing unit and the sensing processing unit are integrated into a system single chip. The invention can ensure that the user is not limited by time and place, regularly detects urine, and carries out the evaluation of the risk index between heart disease or diabetes and kidney disease through continuous detection.)

1. A miniaturized and intelligent urine sensing system is characterized in that the urine sensing system transmits and receives signals through a wireless transmission and reception technology and an intelligent device; the miniaturized and intelligent urine sensing system includes:

the urine sensor test piece is provided with a micro-channel structure and multi-channel structures, each multi-channel structure is respectively provided with a non-biological sensor or a biological sensor, and a plurality of micro pumps, micro mixers, a waste liquid tank for containing waste liquid and an electrolytic tank for containing electrolyte solution are arranged in the micro-channel structure for carrying out a cleaning treatment procedure required by electrochemical sensing when the biological sensor is started for sensing; the multi-channel structure is used for shunting urine to be detected to form a sensing area; and

a urine signal detecting device comprises a power supply unit, a digital controller, a wireless transmitting/receiving circuit, a trigger processing unit and a sensing signal processing unit, wherein the power supply unit, the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing processing unit are integrated into a single system chip, the power supply unit is used for supplying power to the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing signal processing unit, the wireless transmitting/receiving circuit is used for receiving urine measurement modes and channel information transmitted by the intelligent device and transmitting the urine measurement modes and the channel information to the digital controller, and then the trigger processing unit is driven to output a stimulation signal to trigger a biological sensor or a non-biological sensor in the multi-channel structure to perform urine sensing processing on the sensing area, and the sensing signal processing unit detects and processes the electrochemically sensed urine substance concentration of the triggered biological sensor or non-biological sensor according to the urine measuring mode and the channel information and transmits the detected urine substance concentration back to the digital controller, so that the digital controller transmits the detected urine substance concentration to the intelligent device through the wireless transmitting and receiving circuit to evaluate the risk index between the heart disease or the diabetes and the kidney disease.

2. The miniaturized and intelligent urine sensing system of claim 1, wherein: the micro-gate and the micro-pump are controlled by the trigger processing unit, so that the micro-pump and the micro-gate are digitally controlled to open the electrolytic cell to enable the contained electrolyte solution to clean the electrode of the biological sensor, and the waste liquid tank is opened to collect waste liquid, and then electrochemical sensing is performed.

3. The miniaturized and intelligent urine sensing system of claim 1, wherein: the trigger processing unit includes: the urine detection device comprises a voltage digital-to-analog converter, a current digital-to-analog converter, a sine wave generator and an output interface with multi-channel switching, wherein the trigger processing unit is controlled by the digital controller, the output interface with multi-channel switching is connected with a micro-channel structure and a multi-channel structure of the urine sensor test piece, and when the urine detection mode and channel information received by the digital controller are urine detection by a biological sensor, the sine wave generator in the trigger processing unit is driven to execute impedance type measurement to adjust a sine wave output frequency range and adjust sine wave output amplitude; or if the urine measurement mode and the channel information received by the digital controller are urine detection by a non-biological sensor, driving a voltage digital-to-analog converter or a current digital-to-analog converter in the trigger processing unit to perform urine detection, wherein voltage type measurement is performed to adjust output voltage and output time, or current type measurement is performed to adjust output current and output time, and the digital controller drives the voltage, current or impedance measurement processing and collects electrochemical reactions on structures on the urine sensor test piece in a time-division multiplexing mode through the output interface with multi-channel switching.

4. The miniaturized and intelligent urine sensing system of claim 3, wherein: the trigger processing unit has a feedback adjustment function, and when the digital controller drives the voltage digital-to-analog converter, the current digital-to-analog converter or the sine wave generator in the trigger processing unit to perform urine detection on the urine sensor test piece, the digital controller outputs a feedback adjustment output current to the current digital-to-analog converter according to the sensed current value, outputs a feedback adjustment output voltage to the voltage digital-to-analog converter according to the sensed voltage value or outputs a feedback adjustment frequency and amplitude to the sine wave generator according to the sensed impedance value, so that the urine sensor test piece is corrected.

5. The miniaturized and intelligent urine sensing system of claim 1, wherein: the sensing signal processing unit includes: the analog-digital converter, the amplitude detector and the phase detector of the sensing signal processing unit sense the urine substance concentration sensed electrochemically by the triggered biological sensor or non-biological sensor in a time-division multiplexing mode according to the selected measuring mode and channel information through the input interface with multi-channel switching and transmit the sensed urine substance concentration back to the digital controller.

6. The miniaturized and intelligent urine sensing system of claim 1, wherein: the urine material data required to assess the risk index between heart and kidney disease was any one of the group consisting of the concentrations of albumin, creatinine, cystatin C, N telencephalon precursor and cardiac twiddle.

7. The miniaturized and intelligent urine sensing system of claim 1, wherein: the urine material data required to assess the risk index between diabetes and kidney disease is any one of the group consisting of the concentrations of transferrin, N-acetylglucosamine, collagen type IV, tumor necrosis factor alpha, and 8-hydroxydeoxyguanurine core.

8. The miniaturized and intelligent urine sensing system of claim 1, 2, 3, 4, 5, 6, or 7, wherein: the urine sensor test piece and the urine signal detection device are integrated on a portable device, a diaper, a urine bag, underpants, a closestool or a urinal so as to provide a user with urine detection at any time and any place.

9. The miniaturized and intelligent urine sensing system of claim 1, wherein: miniaturized and intelligent urine sensing system sees through intelligent device and high in the clouds server database carry out information transmission in order to realize thing networking function service, high in the clouds server database embeds artificial intelligence algorithm, artificial intelligence algorithm includes: the algorithm is used for carrying out calculation of the risk degree of suffering from the heart diseases and risk assessment of the heart and kidney diseases according to the concentrations of albumin, creatinine, cystatin C, N telencephalon pro-peptide and cardiogyrin in the urine detected by the urine signal detection device, and providing medical personnel and users with the calculation or assessment result through a user interface of the intelligent device.

10. The miniaturized and intelligent urine sensing system of claim 1, wherein: miniaturized and intelligent urine sensing system sees through intelligent device and high in the clouds server database carry out information transmission in order to realize thing networking function service, high in the clouds server database embeds artificial intelligence algorithm, artificial intelligence algorithm includes: the algorithm calculates the degree of risk of diabetes and the risk assessment of diabetes and kidney diseases according to the concentrations of transferrin, N-acetylglucosamine, type IV collagen, tumor necrosis factor alpha and 8-hydroxydeoxyguanopterin nucleus in urine detected by the urine signal detection device, and provides medical personnel and users with the calculation or assessment results through a user interface of the intelligent device.

11. A miniaturized and intelligent urine sensing system is characterized in that the miniaturized and intelligent urine sensing system transmits and receives signals with an intelligent device through a wireless transmission and reception technology; the miniaturized and intelligent urine sensing system includes:

the urine sensor test piece is provided with a multi-channel structure, and each multi-channel structure is respectively provided with a non-biological sensor and a biological sensor; each multi-channel structure is used for shunting urine to be detected so as to form a sensing area; and

a urine signal detecting device comprises a power supply unit, a digital controller, a wireless transmitting/receiving circuit, a trigger processing unit and a sensing signal processing unit, wherein the power supply unit, the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing processing unit are integrated into a single system chip, the power supply unit is used for supplying power to the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing signal processing unit, the wireless transmitting/receiving circuit is used for receiving urine measurement modes and channel information transmitted by the intelligent device and transmitting the urine measurement modes and the channel information to the digital controller, and then the trigger processing unit is driven to output a stimulation signal to trigger a biological sensor or a non-biological sensor in the multi-channel structure to perform urine sensing processing on the sensing area, and the sensing signal processing unit detects and processes the electrochemically sensed urine substance concentration of the triggered biological sensor or non-biological sensor according to the urine measuring mode and the channel information and transmits the detected urine substance concentration back to the digital controller, so that the digital controller transmits the detected urine substance concentration to the intelligent device through the wireless transmitting and receiving circuit to evaluate the risk index between the heart disease or the diabetes and the kidney disease.

12. The miniaturized and intelligent urine sensing system of claim 11, wherein: the trigger processing unit includes: the urine detection device comprises a voltage digital-to-analog converter, a current digital-to-analog converter, a sine wave generator and an output interface with multi-channel switching, wherein the trigger processing unit is controlled by the digital controller, the output interface with multi-channel switching is connected with a multi-channel structure of the urine sensor test piece, and when the urine detection mode and channel information received by the digital controller are urine detection by a biological sensor, the sine wave generator in the trigger processing unit is driven to perform impedance type measurement to adjust a sine wave output frequency range and adjust sine wave output amplitude; or if the urine measurement mode and the channel information received by the digital controller are urine detection by a non-biological sensor, driving a voltage digital-to-analog converter or a current digital-to-analog converter in the trigger processing unit to perform urine detection, wherein voltage type measurement is performed to adjust output voltage and output time, or current type measurement is performed to adjust output current and output time, and the digital controller drives the voltage, current or impedance measurement processing and collects electrochemical reactions on structures on the urine sensor test piece in a time-division multiplexing mode through the output interface with multi-channel switching.

13. The miniaturized and intelligent urine sensing system of claim 12, wherein: the trigger processing unit has a feedback adjustment function, and when the digital controller drives the voltage digital-to-analog converter, the current digital-to-analog converter or the sine wave generator in the trigger processing unit to perform urine detection on the urine sensor test piece, the digital controller outputs a feedback adjustment output current to the current digital-to-analog converter according to the sensed current value, outputs a feedback adjustment output voltage to the voltage digital-to-analog converter according to the sensed voltage value or outputs a feedback adjustment frequency and amplitude to the sine wave generator according to the sensed impedance value, so that the urine sensor test piece is corrected.

14. The miniaturized and intelligent urine sensing system of claim 11, wherein: the sensing signal processing unit includes: the analog-digital converter, the amplitude detector and the phase detector of the sensing signal processing unit sense the urine substance concentration sensed electrochemically by the triggered biological sensor or non-biological sensor in a time-division multiplexing mode according to the selected measuring mode and channel information through the input interface with multi-channel switching and transmit the sensed urine substance concentration back to the digital controller.

15. The miniaturized and intelligent urine sensing system of claim 11, wherein: the urine material data required to assess the risk index between heart and kidney disease was any one of the group consisting of the concentrations of albumin, creatinine, cystatin C, N telencephalon precursor and cardiac twiddle.

16. The miniaturized and intelligent urine sensing system of claim 11, wherein: the urine material data required to assess the risk index between diabetes and kidney disease is any one of the group consisting of transferrin, N-acetylglucosamine, collagen type iv, tumor necrosis factor alpha, and the concentration of 8-hydroxydeoxyguanurine nuclei.

17. The miniaturized and intelligent urine sensing system of claim 11, 12, 13, 14, 15 or 16, wherein: the urine sensor test piece and the urine signal detection device are integrated on a portable device, a diaper, a urine bag, underpants, a closestool or a urinal so as to provide a user with urine detection at any time and any place.

18. The miniaturized and intelligent urine sensing system of claim 11, wherein: miniaturized and intelligent urine sensing system sees through intelligent device and high in the clouds server database carry out information transmission in order to realize thing networking function service, high in the clouds server database embeds artificial intelligence algorithm, artificial intelligence algorithm includes: the algorithm is used for carrying out calculation of the risk degree of suffering from the heart diseases and risk assessment of the heart and kidney diseases according to the concentrations of albumin, creatinine, cystatin C, N telencephalon pro-peptide and cardiogyrin in the urine detected by the urine signal detection device, and providing medical personnel and users with the calculation or assessment result through a user interface of the intelligent device.

19. The miniaturized and intelligent urine sensing system of claim 11, wherein: miniaturized and intelligent urine sensing system sees through intelligent device and high in the clouds server database carry out information transmission in order to realize thing networking function service, high in the clouds server database embeds artificial intelligence algorithm, artificial intelligence algorithm includes: the algorithm is used for carrying out calculation of the degree of risk of suffering from diabetes and risk assessment of diabetes and kidney diseases according to the concentrations of transferrin, N-acetylglucosamine, type IV collagen, tumor necrosis factor alpha and 8-hydroxydeoxyguanopterin nucleus in urine detected by the urine signal detection device, and providing medical personnel and users with the calculation or assessment results through a user interface of the intelligent device.

Technical Field

The invention belongs to the field of urine detection, relates to a sensing system, and particularly relates to a miniaturized and intelligent urine sensing system which is miniaturized by combining an integrated circuit with a urine sensor test piece and is provided with a built-in wireless transmitting and receiving circuit so as to achieve the internet of things and cloud calculation processing.

Background

Most of the existing urine detection instruments are enzyme sensors and are matched with optical detection, detection results need to be waited for a long time, and detection instruments and equipment are quite large in size and can only detect the urine after going to a hospital or a laboratory. However, with the progress of electronic technology, a home self-testing device without the operation of a professional is also developed, the home self-testing device is a handheld device, and a user can provide interpretation analysis for the home self-testing device by inserting the electrode of the urine test strip contaminated with urine to be detected into the home self-testing device.

However, the above-mentioned urine test strip and handheld home self-test device have limitations on the data concentration of the urine to be tested, such as Albumin (Albumin), Creatinine (Creatinine), cystatin c (cystatin c), N-terminal brain natriuretic peptide (NTproBNP), and cardiac muscle rotation protein (Troponin I), in the urine to be tested, because the existing urine test strip adopts a single non-enzymatic structure or an enzymatic structure, the detection circuit in the home self-detection device also needs to be matched with the structural design of the urine detection test piece, that is, if the urine detection test piece adopts an enzyme type structure, the home self-detection device needs to adopt impedance type measurement, and if the urine detection test piece adopts a non-enzyme type structure, the home self-detection device adopts a voltage or current type measurement detection circuit, so that the use of the home self-urine detection device in the market is limited, and the universality is poor; moreover, the self-urine detection device at home still has a certain volume, and the urine detection test piece can be carried to measure the concentration of some substances in urine, so that the self-urine detection device is inconvenient to use, especially for patients lying in bed or patients needing to collect the concentration of urine substances for a long time to observe the health condition.

Furthermore, although the concentration of some substances in urine can be obtained by the above-mentioned home self-urine test device and the urine test strip, since the user is often not a professional medical staff, the symptoms represented by the concentration of some substances in the obtained urine cannot be immediately determined, and the treatment may be delayed.

Therefore, how to provide a urine detection device which is small in size, convenient to use and beneficial to pathological interpretation, and simultaneously, a single urine detection test piece can detect the concentrations of various substances in urine is the technical subject to be solved by the invention.

Disclosure of Invention

In view of the foregoing problems, it is a primary objective of the present invention to provide a miniaturized and intelligent urine sensing system, which is designed to fit a tester for urine detection and can wirelessly transmit the concentration of various substances in the detected urine to the cloud for data analysis.

In order to achieve the above and other related objects, an aspect of the present invention provides a miniaturized and intelligent urine sensing system, wherein the urine sensing system transmits and receives signals with an intelligent device via wireless transmission and reception technology; the miniaturized and intelligent urine sensing system includes:

the urine sensor test piece is provided with a micro-channel structure and multi-channel structures, each multi-channel structure is respectively provided with a non-biological sensor or a biological sensor, and a plurality of micro pumps, micro mixers, a waste liquid tank for containing waste liquid and an electrolytic tank for containing electrolyte solution are arranged in the micro-channel structure for carrying out a cleaning treatment procedure required by electrochemical sensing when the biological sensor is started for sensing; the multi-channel structure is used for shunting urine to be detected to form a sensing area; and a urine signal detecting device having a power supply unit, a digital controller, a wireless transmitting/receiving circuit, a trigger processing unit and a sensing signal processing unit, wherein the power supply unit, the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing processing unit are integrated into a single system chip, wherein the power supply unit is used for supplying power to the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing signal processing unit, the wireless transmitting/receiving circuit is used for receiving the urine measurement mode and the channel information transmitted by the intelligent device and transmitting the urine measurement mode and the channel information to the digital controller, and further driving the trigger processing unit to output a stimulation signal to trigger the biosensor or the non-biosensor in the multi-channel structure to perform the urine sensing processing on the sensing area, and the sensing signal processing unit detects and processes the electrochemically sensed urine substance concentration of the triggered biological sensor or non-biological sensor according to the urine measuring mode and the channel information and transmits the detected urine substance concentration back to the digital controller, so that the digital controller transmits the detected urine substance concentration to the intelligent device through the wireless transmitting and receiving circuit to evaluate the risk index between the heart disease or the diabetes and the kidney disease.

In an embodiment of the present invention, the waste liquid tank and the opening of the electrolytic tank are provided with a micro-gate, and the micro-gate and the micro-pump are controlled by the trigger processing unit to digitally control the micro-pump and the micro-gate to open the electrolytic tank to enable the contained electrolyte solution to clean the electrode of the biosensor, and open the waste liquid tank to collect the waste liquid, and then perform electrochemical sensing.

In an embodiment of the present invention, the trigger processing unit includes: the urine detection device comprises a voltage digital-to-analog converter, a current digital-to-analog converter, a sine wave generator and an output interface with multi-channel switching, wherein the trigger processing unit is controlled by the digital controller, the output interface with multi-channel switching is connected with a micro-channel structure and a multi-channel structure of the urine sensor test piece, and when the urine detection mode and channel information received by the digital controller are urine detection by a biological sensor, the sine wave generator in the trigger processing unit is driven to execute impedance type measurement to adjust a sine wave output frequency range and adjust sine wave output amplitude; or if the urine measurement mode and the channel information received by the digital controller are urine detection by a non-biological sensor, driving a voltage digital-to-analog converter or a current digital-to-analog converter in the trigger processing unit to perform urine detection, wherein voltage type measurement is performed to adjust output voltage and output time, or current type measurement is performed to adjust output current and output time, and the digital controller drives the voltage, current or impedance measurement processing and collects electrochemical reactions on structures on the urine sensor test piece in a time-division multiplexing mode through the output interface with multi-channel switching.

In an embodiment of the invention, the trigger processing unit has a feedback adjustment function, and when the digital controller drives the voltage digital-to-analog converter, the current digital-to-analog converter or the sine wave generator in the trigger processing unit to detect urine in the urine sensor strip, the digital controller outputs a feedback adjustment output current to the current digital-to-analog converter according to the sensed current value, outputs a feedback adjustment output voltage to the voltage digital-to-analog converter according to the sensed voltage value, or outputs a feedback adjustment frequency and amplitude to the sine wave generator according to the sensed impedance value, so as to achieve calibration of the urine sensor strip.

In an embodiment of the present invention, the sensing signal processing unit includes: the analog-digital converter, the amplitude detector and the phase detector of the sensing signal processing unit sense the urine substance concentration sensed electrochemically by the triggered biological sensor or non-biological sensor in a time-division multiplexing mode according to the selected measuring mode and channel information through the input interface with multi-channel switching and transmit the sensed urine substance concentration back to the digital controller.

In one embodiment of the present invention, the urine material data required to assess risk index between heart disease and kidney disease is any one of the group consisting of albumin, creatinine, cystatin C, N telencephalon precursor, and cardiac twiddle protein concentration.

In one embodiment of the present invention, the urine material data required to assess the risk index between diabetes and kidney disease is any one of the group consisting of transferrin, N-acetylglucosamine, type IV collagen, tumor necrosis factor alpha, and 8-hydroxydeoxyguanoine nucleus.

In an embodiment of the present invention, the urine sensor test strip and the urine signal detection device are integrated on a portable device, a diaper, a urine bag, underpants, a toilet or a urinal, so as to provide a user with urine detection anytime and anywhere.

In an embodiment of the present invention, the miniaturized and intelligent urine sensing system performs information transmission with a cloud server database through the intelligent device to implement a functional service of the internet of things, the cloud server database is built with an artificial intelligence algorithm, and the artificial intelligence algorithm includes: the algorithm is used for carrying out calculation of the risk degree of suffering from the heart diseases and risk assessment of the heart and kidney diseases according to the concentrations of albumin, creatinine, cystatin C, N telencephalon pro-peptide and cardiogyrin in the urine detected by the urine signal detection device, and providing medical personnel and users with the calculation or assessment result through a user interface of the intelligent device.

In an embodiment of the present invention, the miniaturized and intelligent urine sensing system performs information transmission with a cloud server database through the intelligent device to implement a functional service of the internet of things, the cloud server database is built with an artificial intelligence algorithm, and the artificial intelligence algorithm includes: the algorithm calculates the degree of risk of diabetes and the risk assessment of diabetes and kidney diseases according to the concentrations of transferrin, N-acetylglucosamine, type IV collagen, tumor necrosis factor alpha and 8-hydroxydeoxyguanopterin nucleus in urine detected by the urine signal detection device, and provides medical personnel and users with the calculation or assessment results through a user interface of the intelligent device.

Another aspect of the present invention provides a miniaturized and intelligent urine sensing system. Performing signal transmission and reception with an intelligent device through wireless transmission and reception technology; the miniaturized and intelligent urine sensing system includes: the urine sensor test piece is provided with a multi-channel structure, and each multi-channel structure is respectively provided with a non-biological sensor and a biological sensor; each multi-channel structure is used for shunting urine to be detected so as to form a sensing area; and a urine signal detecting device having a power supply unit, a digital controller, a wireless transmitting/receiving circuit, a trigger processing unit and a sensing signal processing unit, wherein the power supply unit, the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing processing unit are integrated into a single system chip, wherein the power supply unit is used for supplying power to the digital controller, the wireless transmitting/receiving circuit, the trigger processing unit and the sensing signal processing unit, the wireless transmitting/receiving circuit is used for receiving the urine measurement mode and the channel information transmitted by the intelligent device and transmitting the urine measurement mode and the channel information to the digital controller, and further driving the trigger processing unit to output a stimulation signal to trigger the biosensor or the non-biosensor in the multi-channel structure to perform the urine sensing processing on the sensing area, and the sensing signal processing unit detects and processes the electrochemically sensed urine substance concentration of the triggered biological sensor or non-biological sensor according to the urine measuring mode and the channel information and transmits the detected urine substance concentration back to the digital controller, so that the digital controller transmits the detected urine substance concentration to the intelligent device through the wireless transmitting and receiving circuit to evaluate the risk index between the heart disease or the diabetes and the kidney disease.

In an embodiment of the present invention, the trigger processing unit includes: the urine detection device comprises a voltage digital-to-analog converter, a current digital-to-analog converter, a sine wave generator and an output interface with multi-channel switching, wherein the trigger processing unit is controlled by the digital controller, the output interface with multi-channel switching is connected with a multi-channel structure of the urine sensor test piece, and when the urine detection mode and channel information received by the digital controller are urine detection by a biological sensor, the sine wave generator in the trigger processing unit is driven to perform impedance type measurement to adjust a sine wave output frequency range and adjust sine wave output amplitude; or if the urine measurement mode and the channel information received by the digital controller are urine detection by a non-biological sensor, driving a voltage digital-to-analog converter or a current digital-to-analog converter in the trigger processing unit to perform urine detection, wherein voltage type measurement is performed to adjust output voltage and output time, or current type measurement is performed to adjust output current and output time, and the digital controller drives the voltage, current or impedance measurement processing and collects electrochemical reactions on structures on the urine sensor test piece in a time-division multiplexing mode through the output interface with multi-channel switching.

In an embodiment of the invention, the trigger processing unit has a feedback adjustment function, and when the digital controller drives the voltage digital-to-analog converter, the current digital-to-analog converter or the sine wave generator in the trigger processing unit to detect urine in the urine sensor strip, the digital controller outputs a feedback adjustment output current to the current digital-to-analog converter according to the sensed current value, outputs a feedback adjustment output voltage to the voltage digital-to-analog converter according to the sensed voltage value, or outputs a feedback adjustment frequency and amplitude to the sine wave generator according to the sensed impedance value, so as to achieve calibration of the urine sensor strip.

In an embodiment of the present invention, the sensing signal processing unit includes: the analog-digital converter, the amplitude detector and the phase detector of the sensing signal processing unit sense the urine substance concentration sensed electrochemically by the triggered biological sensor or non-biological sensor in a time-division multiplexing mode according to the selected measuring mode and channel information through the input interface with multi-channel switching and transmit the sensed urine substance concentration back to the digital controller.

In one embodiment of the present invention, the urine material data required to assess risk index between heart disease and kidney disease is any one of the group consisting of albumin, creatinine, cystatin C, N telencephalon precursor, and cardiac twiddle protein concentration.

In one embodiment of the present invention, the urine material data required to assess the risk index between diabetes and kidney disease is any one of the group consisting of transferrin, N-acetylglucosamine, type IV collagen, tumor necrosis factor alpha, and 8-hydroxydeoxyguanoine nucleus.

In an embodiment of the present invention, the urine sensor test strip and the urine signal detection device are integrated on a portable device, a diaper, a urine bag, underpants, a toilet or a urinal, so as to provide a user with urine detection anytime and anywhere.

In an embodiment of the present invention, the miniaturized and intelligent urine sensing system performs information transmission with a cloud server database through the intelligent device to implement a functional service of the internet of things, the cloud server database is built with an artificial intelligence algorithm, and the artificial intelligence algorithm includes: the algorithm is used for carrying out calculation of the risk degree of suffering from the heart diseases and risk assessment of the heart and kidney diseases according to the concentrations of albumin, creatinine, cystatin C, N telencephalon pro-peptide and cardiogyrin in the urine detected by the urine signal detection device, and providing medical personnel and users with the calculation or assessment result through a user interface of the intelligent device.

In an embodiment of the present invention, the miniaturized and intelligent urine sensing system performs information transmission with a cloud server database through the intelligent device to implement a functional service of the internet of things, the cloud server database is built with an artificial intelligence algorithm, and the artificial intelligence algorithm includes: the algorithm is used for carrying out calculation of the degree of risk of suffering from diabetes and risk assessment of diabetes and kidney diseases according to the concentrations of transferrin, N-acetylglucosamine, type IV collagen, tumor necrosis factor alpha and 8-hydroxydeoxyguanopterin nucleus in urine detected by the urine signal detection device, and providing medical personnel and users with the calculation or assessment results through a user interface of the intelligent device.

As mentioned above, the miniaturized and intelligent urine sensing system of the present invention has the following advantages:

the miniaturized and intelligent urine sensing system can enable a user to regularly detect urine without being limited by time and place, and prevent heart diseases or diabetes through continuous detection. Meanwhile, the invention also transmits with the cloud platform through the wireless transmitting and receiving circuit, carries on the assessment of the risk index between heart disease or diabetes and kidney disease through the artificial intelligence algorithm, and provides the user with the reference through the webpage, intelligent device user interface. The invention can also be combined with products such as portable equipment, diapers, urine bags, underpants, toilets or urinals and the like, so that the early screening of cardiovascular diseases or diabetes can be easier to enter the home life and screen in districts.

Drawings

FIG. 1 is a block diagram of the basic architecture of a miniaturized and intelligent urine sensing system according to the present invention.

FIG. 2 is a schematic diagram of an exemplary embodiment of the output interface and the input interface of the urine signal detecting device with multi-channel switching of the miniaturized and intelligent urine sensing system of the present invention.

Fig. 3 is a flowchart illustrating a process of sensing the concentration of urine in the urine sensor strip according to the present invention when the urine sensing system receives a selection command from the intelligent device.

FIG. 4 is a functional block diagram of the trigger processing unit of the urine sensing system of the present invention.

Fig. 5A is a schematic structural view of a urine sensor test strip in the miniaturized and intelligent urine sensing system of the present invention.

FIG. 5B is an appearance schematic diagram of the electrical connection between the urine sensor test strip and the urine signal detection device in the miniaturized and intelligent urine sensing system of the present invention.

Fig. 6 is a conceptual diagram of a basic architecture of the miniaturized and intelligent urine sensing system of the present invention for transmitting information via an intelligent device and a cloud platform to implement a functional service of the internet of things.

Description of the element reference numerals

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.

It should be understood that the structures, ratios, sizes, and the like shown in the drawings and described in the specification are only used for matching with the disclosure of the specification, so as to be understood and read by those skilled in the art, and are not used to limit the conditions under which the present invention can be implemented, so that the present invention has no technical significance, and any structural modification, ratio relationship change, or size adjustment should still fall within the scope of the present invention without affecting the efficacy and the achievable purpose of the present invention. In addition, the terms "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for clarity of description, and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the terms is not to be construed as a scope of the present invention.

Please refer to the block diagram of the basic architecture of the urine sensing system, which is miniaturized and intelligent. Referring to fig. 1, which is a block diagram illustrating a basic architecture of a miniaturized and intelligent urine sensing system 1 according to the present invention, the miniaturized and intelligent urine sensing system 1 includes: a urine sensor test piece 2 and a urine signal detection device 3, the urine signal detection device 3 includes: a power supply unit 30, a digital controller 31, a wireless transmit receive circuit 32, a trigger processing unit 33 and a sensing signal processing unit 34. The urine signal detection device 3 is implemented by a System on Chip (SoC), which means that the power supply unit 30, the digital controller 31, the wireless transceiver circuit 32, the trigger processing unit 33 and the sensing processing unit 34 are integrated into an integrated circuit of the urine signal detection device 3, so as to achieve the purpose of miniaturization. The power supply unit 30 is configured to supply power to the digital controller 31, the wireless transceiver circuit 32, the trigger processing unit 33 and the sensing signal processing unit 34, the linear rectifier 300 of the power supply unit 30 is configured to rectify input energy into a dc voltage lower than the input dc voltage to supply power to the digital controller 31, the wireless transceiver circuit 32, the trigger processing unit 33 and the sensing signal processing unit 34, the single-power-supply/dual-power-supply voltage converter 301 of the power supply unit 30 provides a single power supply or dual power supplies to the trigger processing unit 33 and the sensing processing unit 34 according to chemical characteristics of a biosensor or a non-biosensor to be used by the urine sensor strip 2, and the urine sensor strip 2 is electrochemically sensed by a Three-electrode (Three-electrode) including a working electrode, A reference electrode and a Counter electrode (Counter electrode), wherein the potentiostat of the urine signal detection device 3 provides a potential required for an electrochemical reaction, and the impedance detection circuit measures a change in impedance, i.e., the electrochemical reaction generates a current signal, such that the urine signal detection device 3 analyzes a change in resistance, a change in voltage, or a change in current caused by a substance bond of the urine to be detected, such as Albumin (Albumin), Creatinine (Creatinine), cystatin c (cystatin c), N-terminal brain natriuretic peptide precursor (NTproBNP), cardiac rotonin (Troponin I), transferrin (transferrin), N-acetyl- β -d-glucopyranoside (NAG), Type IV collagen (Type IV collagen), tumor necrosis factor α (TNF- α), 8-hydroxydeoxyguanosine core (8-hydroxy-2' deoxyguanosine,8-OHdG), and the like, and performs signal processing and computation via backend devices (e.g., smart devices or/and cloud server databases).

The urine sensor strip 2 is a multi-material sensor for sensing various cardiovascular and renal disease risk factors, and has a micro-channel structure 20 and a multi-channel structure 21, each multi-channel structure 21 is respectively provided with a biological sensor (Biosensor)22 and a Non-biological sensor (Non-Biosensor)23, a plurality of micro pumps (Micropump), a micro mixer (Micromixer), a Waste liquid tank (Waste chamber) for containing Waste liquid and an electrolytic tank (not shown) for containing an electrolyte solution are arranged in the micro-channel structure 20, and the notches of the Waste liquid tank and the electrolytic tank are provided with micro gates for performing a cleaning processing program required by electrochemical sensing when the biological sensor 22 is started to sense. The micro-flow channel structure 20 is provided with a plurality of micro pumps (micropumps), micro mixers (micromixers), Waste liquid tanks (Waste chambers) and electrolytic tanks, the multi-channel structure 21 is used for shunting urine to be detected to form a sensing area, the biosensor 22 is a biosensor component (such as enzyme, antibody … and the like) for converting the change amount of the urine to be detected into an electric signal, and the biosensor 22 comprises structural designs such as antibody-antigen immunity type, Aptamer (Aptamer) primer modification, Single-chain variable fragment modification (Single-chain variable Fv fragment), enzyme type sensors and the like. It should be noted that some of the biological sensors 22 need to be cleaned for the second time to measure the amount of change, so that the urine signal detection device 3 digitally controls the micro-pump and the micro-gate to open the electrolytic cell to clean the electrodes with the electrolyte solution contained therein and open the waste liquid tank to collect the waste liquid, and then perform electrochemical sensing; the non-biological sensor 23 is a sensor modified by a non-biological sensing component, and includes a non-biological sensor, an electro-catalyst, a molecular template, an ion sensor, etc. the design structure of the urine sensor strip 2 is used to detect the various substance sensing functions of the concentrations of Albumin (Albumin), Creatinine (Creatinine), cystatin c (cystatin c), N-terminal brain natriuretic peptide precursor (NTproBNP), and cardiac muscle rotation protein (Troponin I) in urine, so that the cloud equipment can further calculate the risk index of heart disease and kidney disease through the substance concentrations.

The miniaturized and intelligent urine sensing system 1 of the present invention is a multi-structure urine sensor strip 2, wherein the trigger processing unit 33 and the sensing processing unit 34 provide voltage detection, current detection and impedance detection to realize the sensing processing of biological and non-biological sensors, so as to obtain the sensing of various substances of the substance concentrations of Albumin (Albumin), Creatinine (Creatine), cystatin C (cystatin C), N-terminal brain natriuretic peptide precursor (NTproBNP) and cardiac muscle rotation protein (Troponin I) in the urine, as shown in FIG. 1, the trigger processing unit 33 includes a voltage digital-to-analog converter 330, a current digital-to-analog converter 331, a sine wave generator 332 and an output interface 333 with multi-channel switching, the trigger processing unit 33 is controlled by the digital controller 31, the sensing signal processing unit 34 includes an analog-to-digital converter 340, a current digital-to-analog converter 331, a sine wave generator 332 and an output interface 333 with multi-channel switching, The amplitude detector 341, the phase detector 342 and an input interface 343 with multi-channel switch are used to send the processed signals to the digital controller 31, and the digital controller 31 can send and receive signals with an external intelligent device (not shown) through the wireless transceiver circuit 32, such as an intelligent mobile phone or a computer device.

Next, please refer to fig. 2 for describing an exemplary embodiment of the trigger processing unit 33 'and the sensing signal processing unit 34' of the urine signal detecting device of the urine sensing system of the invention, specifically, the trigger processing unit 33 'of the present embodiment is a processing component for transmitting an output signal of the urine signal detecting device 3, the sensing signal processing unit 34' is a processing component for receiving an input signal of the urine signal detecting device 3, and the trigger core circuit 35 shown in fig. 2 is another processing circuit of the power supply unit 30, the digital controller 31, the wireless transmission receiving circuit 32, the voltage digital-to-analog converter 330, the current digital-to-analog converter 331, the sine wave generator 332, and the like of the urine signal detecting device 3 for simplifying the drawing. The sensing end core circuit 36 is other processing circuits such as the adc 340, the amplitude detector 341 and the phase detector 342 of the urine signal detection device 3, the triggering processing unit end 33' of the urine signal detection device 3 includes an N-to-1 multiplexer 335 and a stimulation signal output unit 334, the stimulation signal output unit 334 at least includes a buffer 3340 and a voltage-to-current conversion interface 3341, the channel structure to be triggered on the urine sensor strip 2 is selected by the N-to-1 multiplexer 335, and the channel structure to be triggered is provided with corresponding voltage detection, current detection or impedance detection to sense the concentration of a specific substance in the urine to be detected, it should be noted that the number of the buffer 3341 and the voltage-to-current conversion interface 3341 of the stimulation signal output unit 334 is plural, the voltage-to-current conversion interface 3341 can perform voltage-to-current conversion or current-to-voltage conversion according to the characteristics of the urine sensor strip, so as to provide voltage or current stimulation, thereby serializing a plurality of parallel voltages or currents.

The sensing signal processing unit end 34' of the urine signal detecting device 3 comprises a 1-to-N demultiplexer 345 and a sampling unit 344, and the sampling unit 344 at least comprises an amplifier 3440 and a voltage-to-current conversion interface 3441. The amplifier 3440 is a signal amplifier and can be restored to the signal level of the voltage or current required by the core circuit 36 at the sensing end through the voltage and current conversion interface 3441.

The sensing end core circuit 36 performs corresponding signal processing on the sensing signal measured by the urine sensor test piece 2 to obtain the characteristic of the substance in the urine to be detected, the signal processing performed by the sensing end core circuit 36 on the sensing signal is to divide the sensing signal into two parts, namely gain (| Z |) and phase (Φ) for detection, which is beneficial to reducing the characteristic of the substance in the urine to be detected and impedance for representing the characteristic of the substance, before detection, a micro-stimulation signal (for example, an alternating current signal I) is injected into the sensing region of the urine sensor test piece 2 by the trigger end core circuit 35, and the sensing signal processing unit end 34 'and the sensing end core circuit 36 are enabled to sense the impedance Z of the characteristic of the substance in the urine to be detected on the sensing region of the urine sensor test piece 2 by the principle of ohm's law, such as the amplitude and phase of the detected signal. It should be noted that the aforementioned tiny alternating current signal may be, for example, a current, a voltage or an electric charge. It should be noted that the amplitude of the core circuit 36 at the sensing end can be a voltage or a current for the purpose of detecting the voltage or the current.

As shown in fig. 3, firstly, in step S1, the user inputs the measurement method and channel information to be selected through the smart phone, and the measurement method and channel information are transmitted from the wireless transceiver circuit 32 of the urine signal detection device 3 to the digital controller 31 to drive the trigger processing unit 33 to perform the urine sensing process.

If the user selects to use the biosensor to perform urine detection, the digital controller 31 drives the sine wave generator 332 in the trigger processing unit 33 to perform operation, i.e. perform impedance measurement in step S332 shown in fig. 3, so as to adjust the frequency range of the sine wave output and adjust the amplitude of the sine wave output; on the contrary, if the user selects to use the non-biological sensor to perform urine detection, the digital controller 31 drives the voltage dac 330 or the current dac 331 in the trigger processing unit 33 to perform urine detection, i.e. the voltage-based measurement in step S330 shown in fig. 3 is performed to adjust the output voltage and the output time, and the current-based measurement in step S331 shown in fig. 3 is performed to adjust the output current and the output time, and the electrochemical characteristics of the urine sensor strip 2 are related by using the voltage dac 330 or the current dac 331. The digital controller 31 also collects the electrochemical reactions in the sensing regions of the urine sensor strip 2 through the output interface 333 with multi-channel switching in a time-division multiplexing manner while driving the voltage, current or impedance measurement process, as shown in step S2 of fig. 3.

Next, as shown in step S3 of fig. 3, the adc 340, the amplitude detector 341 and the phase detector 342 of the sensing signal processing unit 34 perform sensing processing on the concentration signals of Albumin (Albumin), Creatinine (Creatine), cystatin C (cystatin C), N-terminal brain natriuretic peptide (NTproBNP) and cardiac muscle rotation protein (Troponin I) in urine to each sensing region (sensing channel) on the urine sensor strip 2 in a time-division multiplexing manner according to the selected strip channel through the input interface 343 with multi-channel switching, and send the concentration signals back to the digital controller 31.

As can be seen from the above fig. 1 and fig. 3, the urine Sensor test piece 2 of the miniaturized and intelligent urine sensing system 1 of the present invention adopts a micro flow channel and a miniaturized sensing chip (Sensor) design, and is matched with a urine signal detection device 3 with a wireless transmitting and receiving function and an integrated circuit design, so as to achieve the effects of miniaturization and low power consumption, and can be further directly packaged into a portable or portable urine detection product, for example, can be integrated into a portable device, a diaper, a urine bag or underpants, etc., so as to provide a user with urine detection at any time and any place, even can be combined with a toilet or a urinal, and is promoted to an intelligent toilet or an intelligent urinal, etc., for the current urine detection items, most of which are warnings of kidney diseases, but when a kidney problem is found, it is often in the late stage of cardiovascular diseases, only can be used as a reminder treatment, and cannot be prevented and treated early, however, the miniaturized and intelligent urine sensing system 1 of the present invention is suitable for users of all ages to perform a wide-range, fast and early-stage heart disease and kidney disease prediction, thereby truly reducing the number of patients suffering from heart disease and kidney disease and improving the health quality of the people.

In addition, the trigger processing unit 33 of the urine sensing system 1 of the present invention has a feedback adjustment function, as shown in fig. 4, since the urine sensor strip 2 is designed by a chemical reaction, the characteristics of each strip are not completely consistent and have variability, so when the digital controller 31 drives the voltage dac 330, the current dac 331 or the sine wave generator 332 in the trigger processing unit 33 to detect urine in the urine sensor strip 2, a feedback adjustment output current is output to the current dac 331 according to the sensed current value I1, a feedback adjustment output voltage is output to the voltage dac 330 according to the sensed voltage value V1, or a feedback adjustment frequency and amplitude are output to the sine wave generator 332 according to the sensed impedance value R1, thereby achieving the calibration of the urine sensor test piece 2.

Furthermore, the urine sensor strip in the miniaturized and intelligent urine sensing system of the present invention may also be configured without the above-mentioned micro flow channel structure, as shown in fig. 5A and 5B, the urine sensor strip 2 'of the present embodiment may be modified with a catalytic active substance necessary for forming a biosensor or a non-biosensor by an electro-deposition method (electro-deposition), as mentioned above, after the urine to be measured has stayed in the region 24 to be measured of the urine sensor strip 2' for a certain period of time (e.g. about 30 minutes or 1 hour), the user cleans the region 24 to be measured with clean water, and then drops an electrolyte solution on the region 24 to be measured, so that the electrolyte solution contacts with the working electrodes (W1, W2, W3) and the reference electrode R on the region 24 to be measured to perform electrochemical sensing, and the electrolyte solution contacts with the working electrodes (W1, W3, C respectively, W2, W3), the multi-channel 21' connecting the reference electrode R and the counter electrode C, and providing the sensing result to the urine signal detection device 3 for sensing signal processing through the contact electrode E. It should be noted that the number of the urine sensor test piece 2 'and the working electrodes in the present embodiment is not limited to three, and may be less or more, and the number is increased or decreased according to the amount of the urine substance to be sensed by the urine sensor test piece 2'.

Next, please refer to fig. 6, which is a conceptual diagram of a basic architecture of the miniaturized and intelligent urine sensing system 1 according to the present invention for implementing the internet of things function service by performing information transmission via the intelligent device 4 and the cloud platform, such as an artificial intelligence algorithm 50 built in the cloud server database 5 shown in fig. 6, where the artificial intelligence algorithm 50 includes: the early renal disease risk assessment algorithm 51 and the cardiac disease risk assessment algorithm 52 mainly calculate the risk degree of suffering from cardiac disease and the risk assessment of cardiac and renal diseases according to the concentrations of Albumin (Albumin), Creatinine (creatine), cystatin c (cystatin c), N-terminal brain natriuretic peptide precursor (NTproBNP), and cardiac muscle rotation protein (Troponin I) in urine detected by the urine signal detection device 3, and provide medical staff and users through a user interface (APP)40 or a computer user interface of the intelligent device 4 with the calculated or assessed result 54 for medical examination and home care.

In addition, the urine sensor strip of the miniaturized and intelligent urine sensing system according to the present invention has a multi-channel structure, and each of the multi-channel structures is provided with a non-biological sensor or a biological sensor, so that more urine substances can be sensed, and the various substances may include, in addition to the Albumin (Albumin), Creatinine (Creatinine), cystatin c, N-terminal brain natriuretic peptide precursor (NTproBNP), and/or cardiac twitch (Troponin I), transferrin (transferrin), N-acetyl- β -d-glucopyranoside (NAG), Type IV collagen (Type IV collagen), tumor necrosis factor α (TNF- α), and/or 8-hydroxydeoxyguanosine nucleus (8-hydroxy-2' deoxyguanosine,8-OHdG), and the artificial intelligence algorithm 50 of fig. 6 may further include: the diabetes risk assessment algorithm 53 may further assess the risk index between diabetes and kidney disease based on the concentration of the substance.

In addition, the miniaturized and intelligent urine sensing system 1 of the present invention can record and analyze the urine detection record of the user at any time under the interaction with the cloud server database 5 through the transmission and processing of the wireless transmitting and receiving circuit, and provide a large amount of objective urine detection data for a doctor for a long time when the user visits a doctor, so as to provide the doctor with a reference for auxiliary diagnosis. In conclusion, the present invention effectively overcomes various disadvantages of the prior art and has high industrial utilization value.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.