阅读说明：本技术 Ecmo用于心肺功能衰竭治疗的温度控制系统及方法 (Temperature control system and method for ECMO treatment of cardiopulmonary failure ) 是由 韩辉 李琛 王昊 秦伟栋 于 2021-07-06 设计创作，主要内容包括：本发明的ECMO用于心肺功能衰竭治疗的温度控制系统,ECMO包括动力泵、氧合器、血液流出管和血液回流管,温度管理装置由壳体、水箱、循环泵、降温风扇、加热电阻丝以及控制电路组成,降温装置为降温风扇或压缩制冷机,水箱的出水口依次经循环泵和供水管与氧合器的进水口相连通；血液流出管上设置有第一温度传感器,与水箱相连接的供水管和回水管上分别设置有第五温度传感器和第六温度传感器。本发明的温度控制系统及方法,解决了现有体外膜肺氧合ECMO系统只能升温不能降温无法进行精确体温管理的技术问题,避免了冰毯、冰帽体外降温造成冻伤的风险,为心肺功能衰竭治疗的长期治疗提供了必要前提和技术支持。(The ECMO comprises a power pump, an oxygenator, a blood outflow pipe and a blood return pipe, wherein a temperature management device consists of a shell, a water tank, a circulating pump, a cooling fan, a heating resistance wire and a control circuit, the cooling device is the cooling fan or a compression refrigerator, and a water outlet of the water tank is communicated with a water inlet of the oxygenator through the circulating pump and a water supply pipe in sequence; the blood outflow pipe is provided with a first temperature sensor, and a water supply pipe and a water return pipe which are connected with the water tank are respectively provided with a fifth temperature sensor and a sixth temperature sensor. The temperature control system and the method solve the technical problem that the conventional extracorporeal membrane oxygenation ECMO system can only heat up and can not cool down and cannot perform accurate body temperature management, avoid the risk of frostbite caused by external cooling of an ice blanket and an ice cap, and provide necessary preconditions and technical support for long-term treatment of cardiopulmonary failure treatment.)

1. An ECMO temperature control system for treating cardiopulmonary failure comprises a power pump (1), an oxygenator (2), a blood outflow pipe (3) and a blood return pipe (4), wherein the inlet of the power pump is communicated with the veins of a patient through the blood outflow pipe, the outlet of the power pump is communicated with the blood inlet of the oxygenator through a pipeline, and the blood outlet of the oxygenator is communicated with the veins or arteries of the patient through the blood return pipe; the temperature control system is a temperature management device (5); the method is characterized in that: the temperature management device consists of a shell (6), a water tank (7), a circulating pump (9), a cooling device, a heating resistance wire and a control circuit, wherein the cooling device is a cooling fan (8) or a compression refrigerator, the water tank and the circulating pump are both positioned in the shell, and the heating resistance wire is arranged in the water tank and used for heating circulating water in the water tank; the upper end and the lower end of one side surface of the water tank are respectively provided with a water inlet and a water outlet, the water outlet of the water tank is communicated with the water inlet of the oxygenator through a circulating pump and a water supply pipe (10) in sequence, and the water outlet of the oxygenator is communicated with the water inlet of the water tank through a water return pipe (11); under the condition that the cooling device adopts a cooling fan: the lower part of the shell is provided with an air inlet, the cooling fan is arranged at the upper end of the shell, and the cooling fan forms air circulation flow through air draft to realize cooling of circulating water in the water tank; the shell is provided with a display screen which is connected with the control circuit and used for information display;

a first temperature sensor (14) is arranged on the blood outflow tube (3) and is used for measuring the core temperature of the patient; a water supply pipe and a water return pipe which are connected with the water tank are respectively provided with a fifth temperature sensor (18) and a sixth temperature sensor (19), and the fifth temperature sensor and the sixth temperature sensor respectively realize the temperature measurement of water supply and water return; under the condition that the circulating pump adopts a non-turbine pump, an ultrasonic flowmeter is arranged on the water supply pipe or the water return pipe; the cooling fan, the heating resistance wire, the circulating pump, the ultrasonic flowmeter and the first, the fifth and the sixth temperature sensors are all connected with the control circuit.

2. The temperature control system of ECMO for the treatment of cardiopulmonary failure of claim 1, wherein: wave-shaped perforated plates (21) for increasing the mixing effect of circulating water are uniformly distributed in the water tank (7); under the condition that the cooling device adopts a cooling fan (8): the outer surface of the water tank is uniformly fixed with radiating fins (20) with radiating effect.

3. The temperature control system of ECMO for the treatment of cardiopulmonary failure according to claim 1 or 2, wherein: be provided with the stirring vane who increases the circulating water and mix the effect in water tank (7), be provided with on the water tank and order about stirring vane pivoted agitator motor.

4. The temperature control system of ECMO for the treatment of cardiopulmonary failure according to claim 1 or 2, wherein: a third temperature sensor (16) is arranged on a pipeline close to a blood inlet of the oxygenator (2), and a fourth temperature sensor (17) and a second temperature sensor (15) are respectively arranged at one end of the blood return pipe (4) connected with the oxygenator and one end connected with a patient.

5. The temperature control system of ECMO for use in the treatment of cardiopulmonary failure of claim 4, wherein: the first temperature sensor (14), the second temperature sensor (15), the third temperature sensor (16) and the fourth temperature sensor (17) adopt series-type temperature sensors or clamping-type temperature sensors, and the fifth temperature sensor (18) and the sixth temperature sensor (19) adopt series-type temperature sensors.

6. The temperature control system of ECMO for the treatment of cardiopulmonary failure according to claim 1 or 2, wherein: the upper end and the lower end of one side surface of the water tank (7) are respectively provided with a cascade water outlet pipe (12) and a cascade water return pipe (13) which are connected with another temperature management device (5).

7. A temperature control method based on the temperature control system for the treatment of cardiopulmonary failure of ECMO of claim 1, realized by the steps of:

a) selecting a temperature control mode from a common mode, a sub-low temperature mode and an autonomous mode according to different patients, setting the temperature control interval of the common mode as [ T _ PUMin, T _ PUMax ], the temperature control interval of the sub-low temperature mode as [ T _ YAmin, T _ YAmax ], and the temperature control interval of the autonomous mode as [ T _ ZImin, T _ ZImax ]; wherein T _ YAmax is less than T _ PUMin;

b) judging mode conversion, namely judging whether a common mode or an autonomous mode is converted into a sub-low temperature mode at present, and if so, executing a step g); if not, judging whether the sub-low temperature mode is converted into the common mode or the autonomous mode, and if so, executing the step h); if none, indicating the first mode selection, executing step c);

c) core temperature acquisition, the control circuit measuring via the first temperature sensor the temperature T0, T0 of the blood in the blood outflow tube for characterizing the core temperature of the patient;

d) judging the temperature, namely judging whether the acquired core temperature T0 of the patient is in a temperature control interval of a current temperature control mode, if so, keeping the current heating power or cooling power unchanged, and executing the step c); if T0 is lower than the minimum value of the current mode temperature control interval and higher than 35 ℃, performing step e), if T0 is lower than the minimum value of the current mode temperature control interval and lower than 35 ℃, performing step h), if T0 is greater than the maximum value of the current mode temperature control interval and higher than 35 ℃, performing step f), if T0 is greater than the maximum value of the current mode temperature control interval and lower than 35 ℃, performing step g), dynamically detecting T0, and repeating the temperature judgment process;

e) heating control, namely heating circulating water in the water tank by increasing the power of the heating resistance wire, and increasing the temperature of blood by utilizing the heat exchange between the circulating water and the blood in the oxygenator so as to finally achieve the purpose of increasing the core temperature of a patient; performing step c);

f) cooling control, namely cooling the circulating water in the water tank by increasing the power of a cooling fan or a compression refrigerator, and reducing the temperature of the blood by utilizing the heat exchange between the circulating water and the blood in the oxygenator so as to finally realize the purpose of reducing the core temperature of the patient; performing step c);

g) slowly cooling control, namely firstly collecting the core temperature T0 of the patient, and then gradually reducing the power of a heating resistance wire or increasing the power of a cooling fan or a compression refrigerator to realize that the core temperature T0 of the patient is slowly cooled at a cooling rate of 1-1.5 ℃/h;

h) slowly raising the temperature, firstly collecting the core temperature T0 of the patient, and then gradually reducing the power of the heating resistance wire or increasing the power of the heating resistance wire to realize that the core temperature T0 of the patient is slowly lowered at a temperature raising rate of 0.25 ℃/h;

i) the compensation heat quantity display is that the control circuit obtains the water flow quantity V of the water tank through a circulating pump in the form of a turbine pump or an ultrasonic flowmeter, the fifth temperature sensor and the sixth temperature sensor respectively collect the water temperature T1 of the supply pipe and the water temperature T2 of the return pipe, and the compensation heat quantity to the patient in unit time is calculated by using a formula Q = V (T1-T2) c, wherein c is the specific heat capacity of water, if Q is larger than 0, the current heat supply compensation to the patient is indicated, and if Q is smaller than 0, the current heat dissipation compensation to the patient is indicated.

8. A temperature control method based on the temperature control system for the treatment of cardiopulmonary failure of ECMO according to claim 1, wherein the temperature control interval in the normal mode [ T _ PUmin, T _ PUmax ] in step a) is [36 ℃, 37 ℃ ], and the temperature control interval in the sub-low temperature mode [ T _ YAmin, T _ YAmax ] is [32 ℃, 34 ℃; the temperature control interval of the autonomous mode is [ T _ ZImin, T _ ZImax ], and the T _ ZImin and the T _ ZImax can be manually set within the range of 30-39 ℃.

9. A temperature control method based on the temperature control system of ECMO for the treatment of cardiopulmonary failure of claim 1, wherein: the method comprises a temperature comparison step, wherein the core temperature T 'displayed by the patient monitoring equipment is read by measuring the anal temperature, the blood temperature or the video, the T' is compared with the T0, and an alarm signal is sent out if the difference value is more than 0.5 ℃.

Technical Field

The present invention relates to a temperature control system and method, and more particularly, to a temperature control system and method for ECMO therapy for heart and lung failure.

Background

In clinical emergency treatment of severe patients with severe cardiopulmonary failure, extracorporeal membrane pulmonary oxygenation (ECMO) is used to provide continuous extracorporeal respiration and circulation support for the patients, so as to strive for more valuable time for emergency treatment. The core parts of extracorporeal membrane pulmonary oxygenation (ECMO) are artificial lungs (also called membrane lungs or oxygenators) and artificial hearts (also called blood pumps or power pumps), and as the technology of the artificial lungs and the artificial hearts is improved day by day, the ECMO can be maintained for a longer time, which also provides a precondition for the ECMO to be applied to the treatment of patients with cardiopulmonary failure, especially for patients with severe cardiopulmonary failure caused by new coronary pneumonia, and if the ECMO can be used for maintaining the life of the patients for several days, tens of days or even longer, the life of more patients can be saved.

Because the conventional extracorporeal membrane pulmonary oxygenation (ECMO) is evolved from the extracorporeal circulation of the cardiac surgery, and the situation of overhigh core body temperature does not exist in the extracorporeal circulation process, the conventional ECMO standard preparation does not have the function of cooling, only has the function of heating the drained blood, and is one of symptoms of a patient infected with new coronary pneumonia, fever is caused, so that the cooling function of the blood needs to be increased when the conventional ECMO is applied to the treatment of patients with infectious diseases such as the new coronary pneumonia.

Moreover, when patients suffering from new coronary pneumonia infection or secondary craniocerebral injury are treated at present, sub-hypothermia treatment is usually adopted, the metabolism of the patients is reduced by maintaining the body temperature of the patients in a lower temperature range (such as 32 ℃ -34 ℃) so as to achieve the aim of brain protection, and the existing ECMO does not have the function of the sub-hypothermia treatment.

Disclosure of Invention

The present invention overcomes the above-mentioned shortcomings and provides a temperature control system and method for ECMO therapy for cardiopulmonary failure.

The ECMO comprises a power pump, an oxygenator, a blood outflow pipe and a blood return pipe, wherein the inlet of the power pump is communicated with the vein of a patient through the blood outflow pipe, the outlet of the power pump is communicated with the blood inlet of the oxygenator through a pipeline, and the blood outlet of the oxygenator is communicated with the vein or artery of the patient through the blood return pipe; the temperature control system is a temperature management device; the method is characterized in that: the temperature management device consists of a shell, a water tank, a circulating pump, a cooling fan, a heating resistance wire and a control circuit, wherein the cooling device is the cooling fan or a compression refrigerator, the water tank and the circulating pump are both positioned in the shell, and the heating resistance wire is arranged in the water tank and used for heating circulating water in the water tank; the upper end and the lower end of one side surface of the water tank are respectively provided with a water inlet and a water outlet, the water outlet of the water tank is communicated with the water inlet of the oxygenator through a circulating pump and a water supply pipe in sequence, and the water outlet of the oxygenator is communicated with the water inlet of the water tank through a return pipe; under the condition that the cooling device adopts a cooling fan: the lower part of the shell is provided with an air inlet, the cooling fan is arranged at the upper end of the shell, and the cooling fan forms air circulation flow through air draft to realize cooling of circulating water in the water tank; the shell is provided with a display screen which is connected with the control circuit and used for information display;

the blood outflow tube is provided with a first temperature sensor which measures the core temperature of the patient; a water supply pipe and a water return pipe which are connected with the water tank are respectively provided with a fifth temperature sensor and a sixth temperature sensor, and the fifth temperature sensor and the sixth temperature sensor respectively realize the temperature measurement of water supply and water return; under the condition that the circulating pump adopts a non-turbine pump, an ultrasonic flowmeter is arranged on the water supply pipe or the water return pipe; the cooling fan, the heating resistance wire, the circulating pump, the ultrasonic flowmeter and the first, the fifth and the sixth temperature sensors are all connected with the control circuit.

The ECMO is used for the temperature control system for treating the cardiopulmonary failure, and the wavy perforated plates for increasing the mixing effect of circulating water are uniformly distributed in the water tank; under the condition that the cooling device adopts a cooling fan: the outer surface of the water tank is uniformly fixed with radiating fins with radiating effect.

The ECMO temperature control system for the treatment of cardiopulmonary failure comprises a water tank, wherein a stirring blade for increasing the mixing effect of circulating water is arranged in the water tank, and a stirring motor for driving the stirring blade to rotate is arranged on the water tank.

The ECMO temperature control system for treating cardiopulmonary failure comprises a third temperature sensor arranged on a pipeline close to a blood inlet of an oxygenator, and a fourth temperature sensor and a second temperature sensor respectively arranged at one end of a blood return pipe connected with the oxygenator and one end of a blood return pipe connected with a patient.

The ECMO is used for the temperature control system for treating the cardiopulmonary failure, the first temperature sensor (14), the second temperature sensor (15), the third temperature sensor (16) and the fourth temperature sensor (17) adopt series-type temperature sensors or clamping-type temperature sensors, and the fifth temperature sensor (18) and the sixth temperature sensor (19) adopt series-type temperature sensors.

The ECMO temperature control system for the treatment of cardiopulmonary failure comprises a water tank, wherein the upper end and the lower end of one side surface of the water tank are respectively provided with a cascade water outlet pipe and a cascade water return pipe which are connected with other temperature management devices.

The temperature control method of the temperature control system for the treatment of cardiopulmonary failure by ECMO of the present invention is characterized by comprising the following steps:

a) selecting a temperature control mode from a common mode, a sub-low temperature mode and an autonomous mode according to different patients, setting the temperature control interval of the common mode as [ T _ PUMin, T _ PUMax ], the temperature control interval of the sub-low temperature mode as [ T _ YAmin, T _ YAmax ], and the temperature control interval of the autonomous mode as [ T _ ZImin, T _ ZImax ]; wherein T _ YAmax is less than T _ PUMin;

b) judging mode conversion, namely judging whether a common mode or an autonomous mode is converted into a sub-low temperature mode at present, and if so, executing a step g); if not, judging whether the sub-low temperature mode is converted into the common mode or the autonomous mode, and if so, executing the step h); if none, indicating the first mode selection, executing step c);

c) core temperature acquisition, the control circuit measuring via the first temperature sensor the temperature T0, T0 of the blood in the blood outflow tube for characterizing the core temperature of the patient;

d) judging the temperature, namely judging whether the acquired core temperature T0 of the patient is in a temperature control interval of a current temperature control mode, if so, keeping the current heating power or cooling power unchanged, and executing the step c); if T0 is lower than the minimum value of the current mode temperature control interval and higher than 35 ℃, performing step e), if T0 is lower than the minimum value of the current mode temperature control interval and lower than 35 ℃, performing step h), if T0 is greater than the maximum value of the current mode temperature control interval and higher than 35 ℃, performing step f), if T0 is greater than the maximum value of the current mode temperature control interval and lower than 35 ℃, performing step g), dynamically detecting T0, and repeating the temperature judgment process;

e) heating control, namely heating circulating water in the water tank by increasing the power of the heating resistance wire, and increasing the temperature of blood by utilizing the heat exchange between the circulating water and the blood in the oxygenator so as to finally achieve the purpose of increasing the core temperature of a patient; performing step c);

f) cooling control, namely cooling the circulating water in the water tank by increasing the power of a cooling fan or a compression refrigerator, and reducing the temperature of the blood by utilizing the heat exchange between the circulating water and the blood in the oxygenator so as to finally realize the purpose of reducing the core temperature of the patient; performing step c);

g) slowly cooling control, namely firstly collecting the core temperature T0 of the patient, and then gradually reducing the power of a heating resistance wire or increasing the power of a cooling fan or a compression refrigerator to realize that the core temperature T0 of the patient is slowly cooled at a cooling rate of 1-1.5 ℃/h;

h) slowly raising the temperature, firstly collecting the core temperature T0 of the patient, and then gradually reducing the power of the heating resistance wires or increasing the power of the heating resistance wires to realize that the core temperature T0 of the patient is slowly lowered at a temperature raising rate of 0.25 ℃/h;

i) the compensation heat quantity display is that the control circuit obtains the water flow quantity V of the water tank through a circulating pump in the form of a turbine pump or an ultrasonic flowmeter, the fifth temperature sensor and the sixth temperature sensor respectively collect the water temperature T1 of the supply pipe and the water temperature T2 of the return pipe, and the compensation heat quantity to the patient in unit time is calculated by using a formula Q = V (T1-T2) c, wherein c is the specific heat capacity of water, if Q is larger than 0, the current heat supply compensation to the patient is indicated, and if Q is smaller than 0, the current heat dissipation compensation to the patient is indicated.

The temperature control method of the temperature control system for the ECMO therapy of the cardiopulmonary failure comprises the steps that in the step a), the temperature control interval [ T _ PUMin and T _ PUMax ] in the common mode is [36 ℃ and 37 ℃, and the temperature control interval [ T _ YAmin and T _ YAmax ] in the sub-low temperature mode is [32 ℃ and 34 ℃; the temperature control interval of the autonomous mode is [ T _ ZImin, T _ ZImax ], and the T _ ZImin and the T _ ZImax can be manually set within the range of 30-39 ℃.

The temperature control method of the temperature control system for the ECMO treatment of the cardiopulmonary failure comprises a temperature comparison step, wherein the core temperature T 'displayed by patient monitoring equipment is read by measuring the anal temperature, the blood temperature or a video, the T' is compared with the T0, and an alarm signal is sent out if the difference value is more than 0.5 ℃.

The invention has the beneficial effects that: the ECMO temperature control system and method for treating cardiopulmonary failure provided by the invention have the advantages that the temperature management device consisting of the water tank, the circulating pump, the heating resistance wire, the cooling fan or the compression refrigerator and the control circuit is arranged, so that the core temperature of a patient can be increased and the patient with fever can be cooled by the cooling function of the cooling fan or the compression refrigerator in the treatment process of cardiopulmonary failure by using the conventional external membrane pulmonary oxygenation (ECMO) system, further the sub-low temperature treatment of the patient can be realized, the technical problem that the conventional external membrane pulmonary oxygenation ECMO system can only heat up and can not cool down and can not carry out accurate body temperature management is solved, the risk of frostbite caused by external cooling of an ice blanket and an ice cap is avoided, the risk of increasing traumatic operation by using other internal cooling equipment is avoided, and the long-term (days, long-term, short-term, high-temperature, high-free temperature and high-free-temperature treatment are realized by using other internal cooling equipment, Dozens of days or longer) provides necessary preconditions and technical support, has obvious beneficial effects and is suitable for application and popularization.

Drawings

FIG. 1 is a schematic diagram of the temperature control system of the present invention for ECMO therapy for cardiopulmonary failure;

FIG. 2 is a schematic diagram of a mechanism of the temperature management device of the present invention using a cooling fan;

FIG. 3 is a schematic structural diagram of a temperature management device according to the present invention employing a compression refrigerator;

FIG. 4 is a schematic diagram of two or more temperature management devices used in series in the present invention;

FIG. 5 is a cross-sectional view of a water tank of the present invention;

fig. 6 is a schematic structural view of the temperature sensor of the present invention.

In the figure: the device comprises a power pump 1, an oxygenator 2, a blood outflow pipe 3, a blood return pipe 4, a temperature management device 5, a shell 6, a water tank 7, a cooling fan 8, a circulating pump 9, a water supply pipe 10, a water return pipe 11, a cascade water outlet pipe 12, a cascade water return pipe 13, a first temperature sensor 14, a second temperature sensor 15, a third temperature sensor 16, a fourth temperature sensor 17, a fifth temperature sensor 18, a sixth temperature sensor 19, radiating fins 20 and a corrugated perforated plate 21.

Detailed Description

The invention is further described with reference to the following figures and examples.

Because the prior extracorporeal membrane oxygenation (ECMO) is mainly applied to emergency treatment of severe patients with cardiopulmonary failure, and emergency patients are in a lower metabolism state, the prior ECMO only has the function of temperature rise and does not have the function of temperature reduction, and when the ECMO is applied to treatment of patients with cardiopulmonary diseases with fever, the ECMO has the problem that the ECMO can not be cooled as required.

In order to solve the above technical problems, as shown in fig. 1, a schematic structural diagram of a temperature control system for the treatment of cardiopulmonary failure by the ECMO of the present invention is provided, the ECMO is composed of a power pump 1, an oxygenator 2, a blood outflow tube 3 and a blood return tube 4, the power pump 1 is used for simulating an artificial heart, the oxygenator 2 is used for simulating an artificial lung, an inlet of the power pump 1 is communicated with a vein of a patient through the blood outflow tube 3, an outlet of the power pump 1 is communicated with a blood inlet of the oxygenator 2 through a pipeline, and a blood outlet of the oxygenator 2 is communicated with the vein or artery of the patient through the blood return tube 4. When the blood return pipe 4 is connected with the vein of a patient, the device is used for extracorporeal respiration support, and when the blood return pipe 4 is connected with the artery of the patient, the device can be used for extracorporeal respiration support and extracorporeal heart support.

The temperature control system shown is temperature management device 5, temperature management device 5 is by casing 6, water tank 7, cooling fan 8, circulating pump 9, delivery pipe 10, wet return 11, the heating resistor silk, the heat sink, display screen and control circuit constitute, the heat sink realizes the cooling to water tank 7, the patient that the ECMO was treated is the severe patient in the ICU ward usually, the ICU ward is the ward of 24 ℃ of constant temperature usually, consequently, adopt the circulation forced air cooling of cooling fan 8 can satisfy the requirement under the general condition. Under the condition of cooling by the cooling fan 8, the bottom of the shell 6 is opened so as to form air circulation flow in the process of exhausting air by the cooling fan 8 and realize cooling of the circulating water in the water tank 7. In some occasions with higher external temperature, the refrigerant can also be cooled by a compression refrigerator.

The upper end and the lower extreme of water tank 7 one side are provided with water inlet and delivery port respectively, and the delivery port of water tank 7 is linked together with the water inlet of oxygenator 2 through circulating pump 9 and delivery pipe 10 in proper order, and the delivery port of oxygenator 2 is linked together with the water inlet of water tank 7 through wet return 11, and like this, under the drive of circulating pump 9, through driving the circulating water and in water tank 7 and oxygenator 2 circulation flow, the circulating water carries out the heat exchange through carrying out heat exchange with blood in oxygenator 2, and then realizes patient's cooling and temperature rise control. The resistance wire is arranged in the water tank 7 and used for heating circulating water in the water tank 7.

The blood outflow tube 3 is provided with a first temperature sensor 14, the first temperature sensor 14 represents the core temperature of the patient by measuring the blood which just flows out of the body of the patient, and whether the patient is in a fever state can be judged according to the core temperature of the patient, so that the corresponding temperature rise or temperature fall control is realized. A fifth temperature sensor 18 and a sixth temperature sensor 19 are respectively arranged on the water supply pipe 10 and the water return pipe 11 so as to realize the measurement of the water supply temperature and the water return temperature; the circulating pump 9 can adopt a turbine pump, the flow can be calculated by calculating the number of turns of the turbine pump, and under the condition that the circulating pump 9 does not adopt the turbine pump 9, an ultrasonic flowmeter is arranged on the water supply pipe 10 or the water return pipe 11 so as to measure the flow speed of the circulating water.

The line shown close to the blood inlet of the oxygenator 2 is provided with a third temperature sensor 16, the blood return tube 4 close to the blood outlet of the oxygenator 2 is provided with a fourth temperature sensor 17, and the blood return tube 4 is provided with a second temperature sensor 15 close to the patient for temperature measurement at the phase position. Due to the limited heat dissipation effect of the single cooling fan 8, one side of the water tank 7 is provided with a cascade water outlet pipe 12 and a cascade water return pipe 13 which can cascade a plurality of temperature management devices 5 together.

As shown in fig. 2, a schematic diagram of a mechanism of the temperature management device of the present invention when a cooling fan is used is shown, and external air is drawn in from the bottom under the exhaust action of the cooling fan 8, flows through the water tank 7, and flows out from the upper portion, so as to cool the circulating water in the water tank 7. As shown in fig. 3, a schematic structural diagram of the temperature management device of the present invention when a compression refrigerator is adopted is shown, at this time, the compression refrigerator should be arranged to cool the circulating water in the water tank 7. As shown in fig. 4, a schematic diagram of two or more temperature management devices connected in series is shown, and when one temperature management device 5 does not achieve the required cooling effect, two or more temperature management devices should be connected in series to be cooled together to achieve a higher power cooling.

As shown in fig. 5, which shows a cross-sectional view of the water tank of the present invention, a wavy perforated plate 21 for increasing the mixing effect of the circulating water is uniformly distributed in the water tank 7; under the condition that the cooling device adopts the cooling fan 8: the outer surface of the water tank is uniformly fixed with radiating fins 20 having a radiating effect. As shown in fig. 6, a schematic diagram of the structure of the temperature sensor in the present invention is shown, since the water supply pipe 10 or the water return pipe 11 of the water tank 7 is a reusable heat-insulating pipe; the blood outflow tube 3 and the blood return tube 4 of the ECMO blood circulation are disposable tubes, and the first temperature sensor 14, the second temperature sensor 15, the third temperature sensor 16, and the fourth temperature sensor 17 are shown as tandem temperature sensors or clamp temperature sensors, and the fifth temperature sensor 18 and the sixth temperature sensor 19 are shown as tandem temperature sensors.

The temperature control method of the temperature control system for the treatment of cardiopulmonary failure by ECMO of the present invention is characterized by comprising the following steps:

a) selecting a temperature control mode from a common mode, a sub-low temperature mode and an autonomous mode according to different patients, setting the temperature control interval of the common mode as [ T _ PUMin, T _ PUMax ], the temperature control interval of the sub-low temperature mode as [ T _ YAmin, T _ YAmax ], and the temperature control interval of the autonomous mode as [ T _ ZImin, T _ ZImax ]; wherein T _ YAmax is less than T _ PUMin;

b) judging mode conversion, namely judging whether a common mode or an autonomous mode is converted into a sub-low temperature mode at present, and if so, executing a step g); if not, judging whether the sub-low temperature mode is converted into the common mode or the autonomous mode, and if so, executing the step h); if none, indicating the first mode selection, executing step c);

c) core temperature acquisition, the control circuit measuring via the first temperature sensor the temperature T0, T0 of the blood in the blood outflow tube for characterizing the core temperature of the patient;

d) judging the temperature, namely judging whether the acquired core temperature T0 of the patient is in a temperature control interval of a current temperature control mode, if so, keeping the current heating power or cooling power unchanged, and executing the step c); if T0 is lower than the minimum value of the current mode temperature control interval and higher than 35 ℃, performing step e), if T0 is lower than the minimum value of the current mode temperature control interval and lower than 35 ℃, performing step h), if T0 is greater than the maximum value of the current mode temperature control interval and higher than 35 ℃, performing step f), if T0 is greater than the maximum value of the current mode temperature control interval and lower than 35 ℃, performing step g), dynamically detecting T0, and repeating the temperature judgment process;

e) heating control, namely heating circulating water in the water tank by increasing the power of the heating resistance wire, and increasing the temperature of blood by utilizing the heat exchange between the circulating water and the blood in the oxygenator so as to finally achieve the purpose of increasing the core temperature of a patient; performing step c);

f) cooling control, namely cooling the circulating water in the water tank by increasing the power of a cooling fan or a compression refrigerator, and reducing the temperature of the blood by utilizing the heat exchange between the circulating water and the blood in the oxygenator so as to finally realize the purpose of reducing the core temperature of the patient; performing step c);

g) slowly cooling control, namely firstly collecting the core temperature T0 of the patient, and then gradually reducing the power of a heating resistance wire or increasing the power of a cooling fan or a compression refrigerator to realize that the core temperature T0 of the patient is slowly cooled at a cooling rate of 1-1.5 ℃/h;

h) slowly raising the temperature, firstly collecting the core temperature T0 of the patient, and then gradually reducing the power of the heating resistance wires or increasing the power of the heating resistance wires to realize that the core temperature T0 of the patient is slowly lowered at a temperature raising rate of 0.25 ℃/h;

i) the compensation heat quantity display is that the control circuit obtains the water flow quantity V of the water tank through a circulating pump in the form of a turbine pump or an ultrasonic flowmeter, the fifth temperature sensor and the sixth temperature sensor respectively collect the water temperature T1 of the supply pipe and the water temperature T2 of the return pipe, and the compensation heat quantity to the patient in unit time is calculated by using a formula Q = V (T1-T2) c, wherein c is the specific heat capacity of water, if Q is larger than 0, the current heat supply compensation to the patient is indicated, and if Q is smaller than 0, the current heat dissipation compensation to the patient is indicated.

Wherein, the temperature control interval [ T _ PUMin, T _ PUMax ] of the common mode in the step a) is [ [36 ℃, 37 ℃, and the temperature control interval [ T _ YAmin, T _ YAmax ] of the sub-low temperature mode is [32 ℃, 34 ℃; the temperature control interval of the autonomous mode is [ T _ ZImin, T _ ZImax ], and the T _ ZImin and the T _ ZImax can be manually set within the range of 30-39 ℃.

The temperature control method of the temperature control system for the ECMO treatment of the cardiopulmonary failure further comprises a temperature comparison step, wherein the core temperature T 'displayed by the patient monitoring equipment is read through measuring the anal temperature, the blood temperature or a video, the T' is compared with the T0, and an alarm signal is sent out if the difference value is more than 0.5 ℃.