阅读说明：本技术 一种能够治疗改善风湿的膏药贴 (Plaster capable of treating and improving rheumatism ) 是由 戴继扬 于 2021-01-19 设计创作，主要内容包括：本发明涉及膏药贴技术领域,且公开了一种膏药贴,通过将红花提取物、微花藤跟提取物、独活提取物、川穹提取物、徐长卿提取物、豆油和黄丹,炼制成药,涂覆于布上,得到了能够治疗改善风湿的膏药贴,红花具有活血通经、散瘀止痛的作用,微花藤根是可以增强膏药贴对风湿病的针对性,独活主要具有祛风除湿、通痹止痛的效果,独活具有活血行气、祛风止痛的作用,可以起到解郁、通达和止痛的效果,有效地拓展了膏药贴的功效性,徐长卿主要用于治疗风湿、含凝、气滞、血瘀等各种痛症,进一步增强了膏药贴对于风湿病的治疗效果,通过结合各种针对风湿病专项治疗的中药的优势,进一步提高了膏药贴的效用。(The invention relates to the technical field of plaster, and discloses a plaster, which is prepared by refining safflower extract, Japanese creeper root extract, pubescent angelica root extract, szechuan lovage rhizome extract, paniculate swallowwort root extract, soybean oil and yellow lead, coating the mixture on cloth to obtain the plaster capable of treating and improving rheumatism, wherein safflower has the functions of activating blood and dredging channels, dissipating blood stasis and relieving pain, Japanese creeper root can enhance the pertinence of the plaster to rheumatism, the pubescent angelica root mainly has the effects of dispelling wind and removing dampness, and relieving arthralgia and pain, the pubescent angelica root has the functions of activating blood and promoting qi circulation, and dispelling wind and relieving pain, can play the roles of relieving depression, dredging and relieving pain, effectively expands the efficacy of the plaster, the paniculate swallowwort root is mainly used for treating various pains such as rheumatism, coagulation, qi stagnation, blood stasis and the like, further enhances the treatment effect of the plaster on rheumatism, and combines the advantages of various traditional Chinese medicines specially used for treating rheumatism, further improving the effectiveness of the plaster.)

1. A plaster patch is characterized in that: the preparation method of the plaster comprises the following steps:

(1) adding Carthami flos into deionized water, heating to extract, filtering, collecting extractive solution, and separating and purifying by column chromatography at flow rate of 0.5-1mL/min and column temperature of 20-40 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried microtus floridus root into ethanol, raising the temperature for ultrasonic extraction, distilling the extracting solution under reduced pressure to recover ethanol, dispersing the obtained extract into deionized water, extracting with ethyl acetate, separating the water phase by macroporous resin, washing the product, and drying to obtain the microtus floridus root extract;

(3) adding radix Angelicae Pubescentis into ball mill, grinding, dissolving with ethanol, transferring to ultrasonic processor for extraction, centrifuging and drying to obtain radix Angelicae Pubescentis extract;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to extract, filtering to remove residue, mixing filtrates, vacuum distilling and concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting, vacuum distilling, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding radix Cynanchi Paniculati coarse powder into 20-40% ethanol, sealing and soaking for 40-60min, transferring to microwave reactor for extraction, filtering and drying to obtain radix Cynanchi Paniculati extract;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum Preparatium, stirring until the materials are completely melted, continuing adding the Carthami flos extract, the Microflower vine root extract, the radix Angelicae Pubescentis extract, the rhizoma Ligustici Chuanxiong extract and the radix Cynanchi Paniculati extract, decocting with slow fire until the materials are dripped into beads, then removing the fire, cooling at 20-40 deg.C, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.

2. A plaster according to claim 1, wherein: the extraction temperature in the step (1) is 80-100 ℃, and the extraction time is 1-2 h.

3. A plaster according to claim 1, wherein: the temperature of ultrasonic extraction in the step (2) is 60-80 ℃, the time of ultrasonic extraction is 30-50min, and the times are 2-6.

4. A plaster according to claim 1, wherein: when the step (3) is performed, the polishing is performed until the particle size is 100-120 meshes.

5. A plaster according to claim 1, wherein: during the ultrasonic treatment in the step (3), the ultrasonic power is set to be 240-300W, the time is 20-40min, and the temperature is 20-40 ℃.

6. A plaster according to claim 1, wherein: the extraction temperature in the step (4) is 50-70 ℃, the extraction time is 1-3h, and the extraction is repeated for 2-4 times.

7. A plaster according to claim 1, wherein: and (5) setting the power to be 360-420W, the temperature to be 50-70 ℃ and the time to be 5-10mim during microwave extraction.

8. A plaster according to claim 1, wherein: in the step (5), the mass ratio of the yellow lead, the soybean oil, the safflower extract, the microtia floribunda root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract is 100:40-60:0.04-0.1:0.02-0.05:0.01-0.02:0.05-0.12: 0.01-0.03.

Technical Field

The invention relates to the technical field of plaster, in particular to a plaster capable of treating and improving rheumatism.

Background

With the development of the times, the pace of life of people is continuously accelerated, young people in the modern age often have a plurality of bone diseases such as lumbar disc herniation and the like under heavy pressure, the common disease of rheumatic arthralgia and the diseases of old people mostly begin to be gradually younger, most of rheumatic patients are clinically manifested as the pain of joints of the whole body, and show a certain red swelling phenomenon, the disease is hidden and slow, the course of disease is longer, and the diseases are extremely difficult to be cured, most of the existing methods for relieving the rheumatic pain are hormone medicines for oral administration, but the medicines often have side effects, the curative effect is not obvious, and the phenomena such as allergy and the like can occur, so that the patients often cannot turn better for a long time, the joints of the patients are finally deformed, cannot be flicked, and are extremely painful, therefore, an externally applied plaster with small toxic and side effects and obvious therapeutic effects is required to be developed, the adverse effect of the degradation of various functions of the body caused by long-term taking of the medicine is avoided.

The plaster is an external preparation prepared by refining medicinal materials, edible vegetable oil and red lead into a plaster, is coated on a backing material and is pasted on certain parts of a body, and the external preparation is an external preparation which is started from ancient Chinese folks and is generally used for promoting blood circulation to remove blood stasis, tonifying qi and nourishing blood, treating dysmenorrheal and walking, strengthening muscles and bones, relaxing tendons and activating collaterals, opening orifices and penetrating bones and the like.

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the plaster capable of treating and improving rheumatism, and solves the problem that the traditional plaster has poor effect of treating rheumatism.

(II) technical scheme

In order to achieve the purpose, the invention provides the following technical scheme: a plaster patch, the preparation method of the plaster patch comprises the following steps:

(1) adding Carthami flos into deionized water, heating to extract, filtering, collecting extractive solution, separating and purifying by column chromatography at flow rate of 0.5-1mL/min and column temperature of 20-40 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried microtus floridus root into ethanol, raising the temperature for ultrasonic extraction, distilling the extracting solution under reduced pressure to recover ethanol, dispersing the obtained extract into deionized water, extracting with ethyl acetate, separating the water phase by macroporous resin, repeatedly washing the product with deionized water and ethanol, and drying to obtain microtus floridus root extract for later use;

(3) adding radix Angelicae Pubescentis into ball mill, grinding, dissolving with ethanol, transferring to ultrasonic processor for extraction, centrifuging and drying to obtain radix Angelicae Pubescentis extract;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to extract, filtering to remove residue, mixing filtrates, vacuum distilling and concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting with water and ethanol, vacuum distilling to remove ethanol, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding radix Cynanchi Paniculati coarse powder into 20-40% ethanol, sealing and soaking for 40-60min, transferring to microwave reactor for extraction, filtering and drying to obtain radix Cynanchi Paniculati extract;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum Preparatium, stirring until the materials are completely melted, continuing adding the Carthami flos extract, the Microflower vine root extract, the radix Angelicae Pubescentis extract, the rhizoma Ligustici Chuanxiong extract and the radix Cynanchi Paniculati extract, decocting with slow fire until the materials are dripped into beads, then removing the fire, cooling at 20-40 deg.C, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.

Preferably, the extraction temperature in the step (1) is 80-100 ℃, and the extraction time is 1-2 h.

Preferably, the temperature of ultrasonic extraction in the step (2) is 60-80 ℃, the time of ultrasonic extraction is 30-50min, and the times are 2-6.

Preferably, the grinding in the step (3) is performed until the particle size is 100-120 meshes.

Preferably, during the ultrasound in the step (3), the ultrasound power is set to be 240-300W, the time is 20-40min, and the temperature is 20-40 ℃.

Preferably, the extraction temperature in the step (4) is 50-70 ℃, the extraction time is 1-3h, and the extraction is repeated for 2-4 times.

Preferably, during the microwave extraction in the step (5), the power is set to be 360-420W, the temperature is 50-70 ℃, and the time is 5-10 mim.

Preferably, the mass ratio of the yellow lead, the soybean oil, the safflower extract, the microtia floribunda root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract in the step (5) is 100:40-60:0.04-0.1:0.02-0.05:0.01-0.02:0.05-0.12: 0.01-0.03.

(III) advantageous technical effects

Compared with the prior art, the invention has the following beneficial technical effects:

the plaster is prepared by using a water boiling method and a column chromatography separation method to obtain a safflower extract, performing composite purification of ultrasonic extraction and macroporous resin separation and purification to obtain a vine root extract, extracting a radix angelicae pubescentis extract in a ball milling and ultrasonic extraction mode, performing composite purification of alcohol extraction and a macroporous adsorption resin column to obtain a ligusticum chuanxiong hort extract, performing microwave extraction to obtain a paniculate swallowwort root extract, decocting to soybean oil and yellow lead, adding yellow lead, the soybean oil, the safflower extract, the vine root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract into a decocted product, and coating the decocted product on cloth to obtain the plaster capable of treating and improving rheumatism.

The safflower of the plaster has the functions of promoting blood circulation, dredging channels, removing blood stasis and relieving pain, is often used for common diseases such as chest stuffiness and pains, chest and hypochondriac pain, traumatic injury and the like, is added into the plaster, the drug effect of the plaster can be improved, the treatment effect of the plaster on rheumatism is enhanced, the radix fici Pumilae is a common medicament for treating rheumatism, the pertinence of the plaster on rheumatism and the disease can be enhanced, the side effect of the plaster is reduced, the radix angelicae pubescentis mainly has the effects of dispelling wind, eliminating dampness, dredging arthralgia and relieving pain, is commonly used for treating symptoms such as wind-cold-dampness arthralgia, soreness of waist and knees, wind-cold headache and the like, and is added into the components of the plaster as an active component to further enhance the drug property of the plaster, the radix angelicae pubescentis has the functions of promoting blood circulation, promoting qi circulation, dispelling wind and relieving pain, is commonly used for treating symptoms such as wind-cold headache, rheumatism and the like, and can simultaneously, The effect of the plaster is achieved, the efficacy of the plaster is effectively expanded, the paniculate swallowwort root is mainly used for treating various pains such as rheumatism, coagulation, qi stagnation, blood stasis and the like, the treatment effect of the plaster on the rheumatism is further enhanced, and the effectiveness of the plaster is further improved by combining the advantages of various traditional Chinese medicines specially used for treating the rheumatism.

Detailed Description

To achieve the above object, the present invention provides the following embodiments and examples: a plaster patch is prepared by the following steps:

(1) adding Carthami flos into deionized water, heating to 80-100 deg.C, extracting for 1-2 hr, filtering, collecting extractive solution, separating and purifying by column chromatography at flow rate of 0.5-1mL/min and column temperature of 20-40 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried radix Seu caulis Parthenocissi Tricuspidatae into ethanol, heating to 60-80 deg.C, performing ultrasonic extraction for 30-50min, repeatedly extracting for 2-6 times, distilling the extractive solution under reduced pressure to recover ethanol, dispersing the obtained extract in deionized water, extracting with ethyl acetate, separating water phase with macroporous resin, washing the product with deionized water and ethanol repeatedly, and drying to obtain radix Seu caulis Parthenocissi Tricuspidatae extract;

(3) adding radix angelicae pubescentis into a ball mill, grinding to the particle size of 100-;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to 50-70 deg.C, extracting for 1-3 hr, repeatedly extracting for 2-4 times, filtering to remove residue, mixing filtrates, distilling under reduced pressure for concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting with water and ethanol, distilling under reduced pressure to remove ethanol, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding the coarse powder of the paniculate swallowwort root into ethanol with the concentration of 20-40%, sealing and infiltrating for 40-60min, transferring to a microwave reactor for extraction, setting the microwave power of 360-420W, the temperature of 50-70 ℃, the time of 5-10mim, filtering and drying the product to obtain the extract of the paniculate swallowwort root for later use;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum preparatium, stirring until the materials are completely melted, continuously adding the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract, wherein the mass ratio of the Plumbum preparatium, the soybean oil, the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract is 100:40-60:0.04-0.1:0.02-0.05:0.01-0.02:0.05-0.12:0.01-0.03, decocting with slow fire until water drops form beads, then removing the fire, cooling at 20-40 ℃, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.

Example 1

(1) Adding Carthami flos into deionized water, heating to 80 deg.C, extracting for 1 hr, filtering, collecting extractive solution, separating and purifying by column chromatography at flow rate of 0.5mL/min and column temperature of 20 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried microtus floridus root into ethanol, heating to 60 ℃, performing ultrasonic extraction for 30min, repeatedly extracting for 2 times, distilling the extracting solution under reduced pressure to recover ethanol, dispersing the obtained extract into deionized water, extracting with ethyl acetate, separating the water phase by macroporous resin, repeatedly washing the product with deionized water and ethanol, and drying to obtain microtus floridus root extract for later use;

(3) adding radix Angelicae Pubescentis into ball mill, grinding to 100 mesh, dissolving with ethanol, transferring to ultrasonic processor for extraction at 20 deg.C for 20min at power of 240W, centrifuging, and drying to obtain radix Angelicae Pubescentis extract;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to 50 deg.C, extracting for 1 hr, repeatedly extracting for 2 times, filtering to remove residue, mixing filtrates, vacuum distilling and concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting with water and ethanol, vacuum distilling to remove ethanol, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding the coarse powder of the paniculate swallowwort root into 20% ethanol, carrying out sealed infiltration for 40min, transferring to a microwave reactor for extraction, setting the microwave power at 360W and the temperature at 50 ℃ for 5 mm, and filtering and drying the product to obtain a paniculate swallowwort root extract for later use;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum preparatium, stirring until the materials are completely melted, continuously adding the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract, wherein the mass ratio of the Plumbum preparatium, the soybean oil, the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract is 100:40:0.04:0.02:0.01:0.05:0.01, decocting with slow fire until the water drops form beads, then removing the fire, cooling at 20 ℃, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.

Example 2

(1) Adding Carthami flos into deionized water, heating to 85 deg.C, extracting for 1.5 hr, filtering, collecting extractive solution, separating and purifying by column chromatography at flow rate of 0.6mL/min and column temperature of 25 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried microtus floridus root into ethanol, raising the temperature to 65 ℃, performing ultrasonic extraction for 35min, repeatedly extracting for 3 times, distilling the extracting solution under reduced pressure to recover ethanol, dispersing the obtained extract into deionized water, extracting with ethyl acetate, separating the water phase by macroporous resin, repeatedly washing the product with deionized water and ethanol, and drying to obtain microtus floridus root extract for later use;

(3) adding radix Angelicae Pubescentis into ball mill, grinding to particle size of 110 mesh, dissolving with ethanol, transferring to ultrasonic processor for extraction at 25 deg.C for 25min at power of 260W, centrifuging, and drying to obtain radix Angelicae Pubescentis extract;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to 55 deg.C, extracting for 2 hr, repeatedly extracting for 3 times, filtering to remove residue, mixing filtrates, vacuum distilling and concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting with water and ethanol, vacuum distilling to remove ethanol, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding the coarse powder of the paniculate swallowwort root into 25% ethanol, sealing and soaking for 45min, transferring to a microwave reactor for extraction, setting the microwave power at 380W, the temperature at 55 ℃ and the time at 6 mm, and filtering and drying the product to obtain a paniculate swallowwort root extract for later use;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum preparatium, stirring until the materials are completely melted, continuously adding the safflower extract, the microtia floribunda root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract, wherein the mass ratio of the Plumbum preparatium to the soybean oil to the safflower extract to the microtia floribunda root extract to the radix angelicae pubescentis extract to the ligusticum chuanxiong hort extract to the paniculate swallowwort root extract is 100:45:0.055:0.026:0.012:0.07:0.015, decocting with slow fire until the water drops into beads, then cooling at 25 ℃, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.

Example 3

(1) Adding Carthami flos into deionized water, heating to 90 deg.C, extracting for 1.5 hr, filtering, collecting extractive solution, separating and purifying by column chromatography at flow rate of 0.6mL/min and column temperature of 30 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried microtus floridus root into ethanol, raising the temperature to 70 ℃, performing ultrasonic extraction for 40min, repeatedly extracting for 4 times, distilling the extracting solution under reduced pressure to recover ethanol, dispersing the obtained extract into deionized water, extracting with ethyl acetate, separating the water phase by macroporous resin, repeatedly washing the product with deionized water and ethanol, and drying to obtain microtus floridus root extract for later use;

(3) adding radix Angelicae Pubescentis into ball mill, grinding to particle size of 110 mesh, dissolving with ethanol, transferring to ultrasonic processor for extraction at 30 deg.C for 30min at power of 260W, centrifuging, and drying to obtain radix Angelicae Pubescentis extract;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to 60 deg.C, extracting for 2 hr, repeatedly extracting for 3 times, filtering to remove residue, mixing filtrates, vacuum distilling and concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting with water and ethanol, vacuum distilling to remove ethanol, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding radix Cynanchi Paniculati coarse powder into 30% ethanol, sealing and soaking for 50min, transferring into a microwave reactor for extraction, setting microwave power at 380W, temperature at 60 deg.C and time at 6 mm, filtering and drying to obtain radix Cynanchi Paniculati extract;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum preparatium, stirring until the materials are completely melted, continuously adding the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract, wherein the mass ratio of the Plumbum preparatium, the soybean oil, the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract is 100:50:0.07:0.035:0.015:0.09:0.02, decocting with slow fire until the water drops form beads, then removing the fire, cooling at 30 ℃, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.

Example 4

(1) Adding Carthami flos into deionized water, heating to 95 deg.C, extracting for 1.5h, filtering, collecting extractive solution, separating and purifying by column chromatography at flow rate of 0.8mL/min and column temperature of 35 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried microtus floridus root into ethanol, raising the temperature to 75 ℃, performing ultrasonic extraction for 45min, repeatedly extracting for 5 times, distilling the extracting solution under reduced pressure to recover ethanol, dispersing the obtained extract into deionized water, extracting with ethyl acetate, separating the water phase by macroporous resin, repeatedly washing the product with deionized water and ethanol, and drying to obtain microtus floridus root extract for later use;

(3) adding radix Angelicae Pubescentis into ball mill, grinding to particle size of 110 mesh, dissolving with ethanol, transferring to ultrasonic processor for extraction at 35 deg.C for 35min at power of 280W, centrifuging, and drying to obtain radix Angelicae Pubescentis extract;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to 65 deg.C, extracting for 2 hr, repeatedly extracting for 3 times, filtering to remove residue, mixing filtrates, vacuum distilling and concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting with water and ethanol, vacuum distilling to remove ethanol, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding the coarse powder of the paniculate swallowwort root into 35% ethanol, sealing and soaking for 55min, transferring to a microwave reactor for extraction, setting the microwave power at 400W, the temperature at 65 ℃ and the time at 8 mm, and filtering and drying a product to obtain a paniculate swallowwort root extract for later use;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum preparatium, stirring until the materials are completely melted, continuously adding the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract, wherein the mass ratio of the Plumbum preparatium, the soybean oil, the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract is 100:55:0.085:0.04:0.018:0.11:0.025, decocting with slow fire until water drops form beads, subsequently removing the fire, cooling at 35 ℃, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.

Example 5

(1) Adding Carthami flos into deionized water, heating to 100 deg.C, extracting for 2 hr, filtering, collecting extractive solution, separating and purifying by column chromatography at flow rate of 1mL/min and column temperature of 40 deg.C, and drying to obtain Carthami flos extract;

(2) adding dried microtus floridus root into ethanol, heating to 80 ℃, performing ultrasonic extraction for 50min, repeatedly extracting for 6 times, distilling the extracting solution under reduced pressure to recover ethanol, dispersing the obtained extract into deionized water, extracting with ethyl acetate, separating the water phase by macroporous resin, repeatedly washing the product with deionized water and ethanol, and drying to obtain microtus floridus root extract for later use;

(3) adding radix Angelicae Pubescentis into ball mill, grinding to particle size of 120 mesh, dissolving with ethanol, transferring to ultrasonic processor for extraction at 40 deg.C for 40min at 300W, centrifuging, and drying to obtain radix Angelicae Pubescentis extract;

(4) adding rhizoma Ligustici Chuanxiong coarse powder into ethanol, heating to 70 deg.C, extracting for 3 hr, repeatedly extracting for 4 times, filtering to remove residue, mixing filtrates, vacuum distilling and concentrating, dissolving the obtained extract with deionized water, vacuum filtering, transferring the filtrate to macroporous adsorbent resin column, eluting with water and ethanol, vacuum distilling to remove ethanol, and drying to obtain rhizoma Ligustici Chuanxiong extract;

(5) adding radix Cynanchi Paniculati coarse powder into 40% ethanol, sealing and soaking for 60min, transferring into a microwave reactor for extraction, setting microwave power at 420W, temperature at 70 deg.C and time at 10 mm, filtering and drying to obtain radix Cynanchi Paniculati extract;

(6) placing soybean oil in an iron pan, refining to be thick, adding Plumbum preparatium, stirring until the materials are completely melted, continuously adding the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract, wherein the mass ratio of the Plumbum preparatium, the soybean oil, the safflower extract, the microtia florea root extract, the radix angelicae pubescentis extract, the ligusticum chuanxiong hort extract and the paniculate swallowwort root extract is 100:60:0.1:0.05:0.02:0.12:0.03, decocting with slow fire until the water drops form beads, then removing the fire, cooling at 40 ℃, melting with slow fire, and spreading on cloth to obtain the plaster capable of treating and improving rheumatism.