阅读说明：本技术 被膜形成用组合物 (Composition for forming coating film ) 是由 井本鹰行 坂田瑞希 胜家睦洋 庄子武明 于 2019-06-28 设计创作，主要内容包括：本发明的课题是提供可以更简单地形成保湿性优异的被膜的组合物。解决手段是一种被膜形成用组合物,其特征在于,含有至少1种由低分子脂质肽或其药学上能够使用的盐构成的脂质肽型化合物。上述脂质肽型化合物优选为在由碳原子数9～23的脂肪族基构成的脂质部上结合具有氨基酸的重复结合结构的肽部的化合物。(The invention provides a composition capable of forming a film with excellent moisture retention more simply. The solution is a composition for forming a coating, characterized by containing at least 1 lipid peptide type compound composed of a low molecular lipid peptide or a pharmaceutically usable salt thereof. The lipid peptide-based compound is preferably a compound in which a peptide part having a repeating structure of amino acids is bonded to a lipid part composed of an aliphatic group having 9 to 23 carbon atoms.)

1. A composition for forming a coating film, comprising at least 1 lipid peptide-type compound comprising a low-molecular-weight lipid peptide or a pharmaceutically acceptable salt thereof.

2. The composition for forming a coating according to claim 1, wherein the lipid peptide-type compound is a compound in which a peptide part having a repeating structure of amino acids is bonded to a lipid part comprising an aliphatic group having 9 to 23 carbon atoms.

3. The composition for forming a coating film according to claim 2, wherein the lipid peptide-type compound is composed of at least 1 of compounds represented by the following formulae (1) to (3) or pharmaceutically acceptable salts thereof,

in the formula (1), R¹R represents an aliphatic group having 9 to 23 carbon atoms²Represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and having a branched chain of 1 or 2 carbon atoms, R³Is represented by- (CH)₂)_n-X, n represents a number from 1 to 4, X represents an amino group, a guanidino group, -CONH₂A group, a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, wherein the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms;

in the formula (2), R⁴R represents an aliphatic group having 9 to 23 carbon atoms⁵～R⁷Each independent earth surfaceA hydrogen atom, a C1-4 alkyl group which may have a C1 or C2 branched chain, or- (CH)₂)_n-X, n represents a number from 1 to 4, X represents an amino group, a guanidino group, -CONH₂A group, a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, wherein the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms;

in the formula (3), R⁸R represents an aliphatic group having 9 to 23 carbon atoms⁹～R¹²Each independently represents a hydrogen atom, a C1-4 alkyl group which may have a C1 or C2 branch, or- (CH)₂)_n-X, n represents a number from 1 to 4, X represents an amino group, a guanidino group, -CONH₂The heterocyclic group may be a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, and the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms.

4. A method for producing a coating film, characterized by using the coating film-forming composition according to any one of claims 1 to 3.

5. A coating film produced by using the composition for forming a coating film according to any one of claims 1 to 3.

Technical Field

The present invention relates to a composition for forming a coating film, and more particularly, to a composition for forming a coating film containing at least 1 lipid peptide-type compound.

Background

In the field of cosmetics and hair styling products, a film formed on the skin or on the hair surface effectively blocks the skin or on the hair surface, and therefore, plays various important roles in personalized care products such as suppression of evaporation of water in the skin or hair and improvement of retention of active ingredients.

With the recent increase in health consciousness, particularly dry muscle consciousness, a cosmetic composition having a good moisturizing effect has been desired. As a skin care preparation exhibiting a high moisturizing effect, a film cosmetic material utilizing a self-assembled structure such as a substance utilizing a lamellar α -gel is exemplified (patent document 1). Further, intercellular lipids in the stratum corneum, which is the stratum corneum layer existing in the outermost layer of the skin, also have a function of inhibiting the invasion of foreign substances into the skin and the evaporation of water from the inside by forming a self-assembled layered structure, thereby maintaining moisture retention and skin softness.

In addition, hair preparations using polypeptides have been proposed in order to reduce hair damage caused by brush coating, heat treatment using a dryer, or the like (patent documents 2 and 3).

Documents of the prior art

Patent document

Patent document 1: japanese patent laid-open publication No. 2016-

Patent document 2: japanese laid-open patent publication No. 10-77210

Patent document 3: japanese patent laid-open publication No. 2002-308756

Disclosure of Invention

Problems to be solved by the invention

In order to form the lamellar α -gel, it is necessary to mix a plurality of components at a specific ratio, and therefore, when the lamellar α -gel is used in combination with other components, the adjustment of the mixing ratio of the plurality of components and the other components may become complicated.

In addition, when a polymer such as polypeptide is used for the film-forming agent, the use feeling is required to be improved because the polymer has a unique tight feeling.

The purpose of the present invention is to provide a composition capable of more easily forming a film having excellent moisture retention.

Further, an object of the present invention is to provide a composition capable of forming a coating film having an improved feeling of use with little tension or the like.

Means for solving the problems

The present inventors have conducted intensive studies to solve the above problems, and as a result, have found that a film is formed on the skin and on the hair surface only by using at least 1 lipid peptide-type compound, and the obtained film is further excellent in moisture retention, 2. inhibition of adsorption of moisture, 3. promotion of penetration into the hair, 4. adsorption of negatively charged components, and 5. inhibition of association of oil components, thereby completing the present invention.

The present inventors have also found that the coating film has little feeling of tightness and the like and is excellent in feeling of use, and have completed the present invention.

That is, the present invention relates to, as a first aspect, a composition for forming a coating film, which comprises at least 1 lipid peptide-type compound comprising a low-molecular-weight lipid peptide or a pharmaceutically acceptable salt thereof.

A second aspect of the present invention relates to the composition for forming a coating film according to the first aspect of the present invention, wherein the lipid peptide compound is a compound in which a peptide part having a repeating structure of amino acids is bonded to a lipid part composed of an aliphatic group having 9 to 23 carbon atoms.

A3 rd aspect relates to the composition for forming a coating film according to 2 nd aspect, wherein the lipid peptide compound is composed of at least 1 of compounds represented by the following formulae (1) to (3) or pharmaceutically acceptable salts thereof.

(in the formula (1), R¹R represents an aliphatic group having 9 to 23 carbon atoms²Represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and having a branched chain of 1 or 2 carbon atoms, R³Is represented by- (CH)₂)_n-X, n represents a number from 1 to 4, X represents an amino group, a guanidino group, -CONH₂The heterocyclic group may be a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, and the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms. )

(in the formula (2), R⁴R represents an aliphatic group having 9 to 23 carbon atoms⁵～R⁷Each independently represents a hydrogen atom, a C1-4 alkyl group which may have a C1 or C2 branch, or- (CH)₂)_n-X, n represents a number from 1 to 4, X represents an amino group, a guanidino group, -CONH₂The heterocyclic group may be a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, and the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms. )

(in the formula (3), R⁸R represents an aliphatic group having 9 to 23 carbon atoms⁹～R¹²Each independently represents a hydrogen atom, a C1-4 alkyl group which may have a C1 or C2 branch, or- (CH)₂)_n-X, n represents a number from 1 to 4, X represents an amino group, a guanidino group, -CONH₂The heterocyclic group may be a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, and the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms. )

The 4 th aspect of the present invention relates to a method for producing a coating film, which comprises using the composition for forming a coating film according to any one of the 1 st to 3 rd aspects.

The 5 th aspect of the present invention relates to a coating film produced using the composition for forming a coating film according to any one of the 1 st to 3 rd aspects.

ADVANTAGEOUS EFFECTS OF INVENTION

According to the present invention, a coating film having excellent moisture retention can be formed by containing at least 1 lipid peptide-based compound. That is, since it is not necessary to excessively adjust the ratio of each component in the composition, a film having excellent moisture retention can be more easily formed.

Further, according to the present invention, if blended in a cosmetic or the like, excellent moisture retention can be imparted to the cosmetic.

Further, according to the present invention, a coating film having a good feeling of use, such as little tension, can be formed.

According to the present invention, a coating film having at least 1 or more of the following effects, among which an effect of suppressing reflection of light, an effect of water repellency, an effect of finger-through property and comb-through property, an effect of making cosmetic floating powder less likely to occur, an effect of imparting gloss, and an effect of having a high retention force of an active ingredient (capable of containing a large amount of an active ingredient), can be further formed.

The lipid peptide-type compound used in the present invention is an artificial low-molecular compound composed only of lipids and peptides and having very high safety, and therefore the composition of the present invention has high biological safety and is particularly useful for pharmaceuticals, cosmetics, and the like.

Drawings

Fig. 1 is a Scanning Electron Microscope (SEM) image in example 1, wherein [ (a) is an SEM image of the sample immediately after the sample is set on the scanning electron microscope (the numbers in the figure indicate the positions of droplets of a typical mineral oil). (b) The SEM image of the dried sample was obtained (the numbers in the figure indicate the positions of the droplets of the mineral oil shown in (a)). ]

Fig. 2 shows appearance photographs in example 3 and comparative example 3, wherein [ (a) shows an appearance photograph in example 3. (b) Photograph of appearance of comparative example 3. ].

Fig. 3 shows Scanning Electron Microscope (SEM) images in example 3 and comparative example 3, where [ (a) is the SEM image of example 3. (b) Is an SEM image of comparative example 3. ].

Fig. 4 is a graph showing the results of the shampoo moisturizing test (moisturizing rate of hair) in examples 4 to 8 and comparative example 4.

Fig. 5 is a graph showing the results of the contact angle measurement in example 9 and comparative example 5, and [ (a) is a graph showing the results of the contact angle measurement in example 9. (b) The results of the contact angle measurement in comparative example 5 are shown. ].

Fig. 6 is a graph showing the results of the conditioner moisturizing test (moisturizing rate of hair) in example 10 and comparative example 6.

Fig. 7 is a Scanning Electron Microscope (SEM) image of the hair after the conditioner moisturizing test in example 10 and comparative example 6, where [ (a) is the SEM image of example 10. (b) Is an SEM image of comparative example 6. ]

Fig. 8 is a graph showing the measurement results of the frictional resistance in example 11 and comparative example 7.

Fig. 9 is a graph showing the results of the reflected light intensity measurement in example 13 and comparative example 9.

Fig. 10 is an appearance photograph of example 14 and comparative example 10 [ (a) is an appearance photograph of comparative example 10. (b) Is an appearance photograph of example 14. ].

FIG. 11 is a graph showing the results of quantifying malic acid in example 18 and comparative example 14.

Fig. 12 is a Scanning Electron Microscope (SEM) image of hair after example 19, comparative example 15, and hair conditioner treatment for damaged hair [ (a) is an SEM image of damaged hair. (b) Is an SEM image of example 19. (c) Is an SEM image of comparative example 15. ]

Fig. 13 is a graph showing the results of the dynamic friction coefficient measurement in example 21 and comparative example 17.

Fig. 14 is a graph showing the results of quantifying the amount of succinic acid in hair treated with conditioner in example 23 and comparative example 19.

Fig. 15 is a graph showing the results of evaluation of the permeation amounts of succinic acid and lipid peptides in human hairs in example 24 and comparative example 20.

Fig. 16 is a graph showing the results of evaluating the hardness of the hair surface treated with conditioner in example 26, comparative example 22, and dark hair and damaged hair.

Fig. 17 is a graph showing the results of evaluation of the adsorption and desorption of moisture after conditioner treatment in example 27, comparative example 23, and damaged hair.

Fig. 18 is a graph showing the results of observing the change with time of the gloss due to sebum floating in example 28 and comparative example 24.

Fig. 19 is a graph showing moisturizing effects of the cosmetic liquids of example 30 and comparative example 26.

Fig. 20 is a graph showing the results of quantifying the amount of keratin in hair treated with conditioners in example 33, example 34 and comparative example 28.

Fig. 21 is a Scanning Electron Microscope (SEM) image of hair after treatment of example 36, comparative example 30 and a hair conditioner for damaged hair [ (a) is an SEM image of example 36. (b) Is an SEM image of comparative example 30. (c) SEM images of damaged hair. ]

Detailed Description

The present invention relates to a composition for forming a coating film, which is characterized by containing at least 1 lipid peptide type compound composed of a low molecular lipid peptide or a pharmaceutically usable salt thereof.

The composition for forming a coating film in the present invention is a composition which is industrially useful due to the film-forming property, and particularly a composition for forming a coating film on the surface of skin or hair as a film-forming object, but is not limited to the use in paints, coating materials, sealers, primers, correction fluids, and the like.

The lipid peptide compound is preferably a compound in which a peptide part having a repeating structure of amino acids is bonded to a lipid part composed of an aliphatic group having 9 to 23 carbon atoms.

The lipid peptide-type compound is more preferably composed of at least 1 of the compounds (lipid peptides) represented by the following formulae (1) to (3) or pharmaceutically usable salts thereof (low-molecular-weight compounds having a lipid moiety as a hydrophobic moiety and a peptide moiety as a hydrophilic moiety).

In the above formula (1), R¹Represents an aliphatic group having 9 to 23 carbon atoms, preferably R¹Is a linear aliphatic group having 11 to 23 carbon atoms and optionally having 0 to 2 unsaturated bonds.

As a group consisting of R¹Specific examples of the lipid moiety (acyl group) composed of an adjacent carbonyl group include lauroyl group, dodecylcarbonyl group, myristoyl group, tetradecylcarbonyl group, palmitoyl group, heptadecanoyl group, oleoyl group, elaidic group, linoleoyl group, stearoyl group, 11-octadecenoyl group, octadecylcarbonyl group, arachidonoyl group, eicosylcarbonyl group, behenoyl group, erucyl group, docosylcarbonyl group, lignoceryl group, and ceramide group, and particularly preferable examples include lauroyl group, myristoyl group, palmitoyl group, heptadecanoyl group, stearoyl group, oleoyl group, elaidic group, and behenoyl group.

In the above formula (1), R contained in the peptide moiety²Represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain of 1 or 2 carbon atoms.

The above-mentioned alkyl group having 1 to 4 carbon atoms, which may have a branched chain of 1 or 2 carbon atoms, represents an alkyl group having 1 to 4 carbon atoms in the main chain and may have a branched chain of 1 or 2 carbon atoms, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group and the like.

R is as defined above²Preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and having a branched chain of 1 carbon atom, and more preferably a hydrogen atom.

The alkyl group having 1 to 3 carbon atoms which may have a branched chain of 1 carbon atom means an alkyl group having 1 to 3 carbon atoms in the main chain and may have a branched chain of 1 carbon atom, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an isobutyl group, a sec-butyl group and the like, and preferably a methyl group, an isopropyl group, an isobutyl group or a sec-butyl group.

In the above formula (1), R³Is represented by- (CH)₂)_n-a radical X. In the above-mentioned- (CH)₂)_nIn the group-X, n represents a number of 1 to 4, X represents an amino group, a guanidino group or-CONH₂The heterocyclic group may be a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, and the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms.

In the above-mentioned formula R³Of (CH)₂)_nIn the radical-X, X is preferably amino, guanidino, carbamoyl (-CONH)₂An imidazolyl group), a pyrrolyl group, an imidazolyl group, a pyrazolyl group or an indolyl group, more preferably an imidazolyl group. In addition, in the above- (CH)₂)_nIn the radical-X, n is preferably 1 or 2, more preferably 1.

Thus, the above- (CH)₂)_nThe group-represents preferably aminomethyl, 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, carbamoylmethyl, 2-carbamoylethyl, 3-carbamoylbutyl, 2-guanidinoethyl, 3-guanidinobutyl, pyrromethyl, 4-imidazolylmethyl, pyrazolylmethyl or 3-indolylmethyl, more preferably 4-aminobutyl, carbamoylmethyl, 2-carbamoylethyl, 3-guanidinobutyl, 4-imidazolylmethyl or 3-indolylmethyl, still more preferably 4-imidazolylmethyl.

Among the compounds represented by the above formula (1), the lipid peptide particularly suitable as the lipid peptide-type compound is a compound comprising a lipid moiety and a peptide moiety (amino acid assembly moiety) as follows. In the present specification, the abbreviation of amino acid means alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isoleucine (Ile), leucine (Leu), lysine (Lys), tryptophan (Trp), and valine (Val). : lauroyl-Gly-His, lauroyl-Gly-Gln, lauroyl-Gly-Asn, lauroyl-Gly-Trp, lauroyl-Gly-Lys, lauroyl-Ala-His, lauroyl-Ala-Gln, lauroyl-Ala-Asn, lauroyl-Ala-Trp, lauroyl-Ala-Lys; myristoyl-Gly-His, myristoyl-Gly-Gln, myristoyl-Gly-Asn, myristoyl-Gly-Trp, myristoyl-Gly-Lys, myristoyl-Ala-His, myristoyl-Ala-Gln, myristoyl-Ala-Asn, myristoyl-Ala-Trp, myristoyl-Ala-Lys; palmitoyl-Gly-His, palmitoyl-Gly-Gln, palmitoyl-Gly-Asn, palmitoyl-Gly-Trp, palmitoyl-Gly-Lys, palmitoyl-Ala-His, palmitoyl-Ala-Gln, palmitoyl-Ala-Asn, palmitoyl-Ala-Trp, palmitoyl-Ala-Lys; stearoyl-Gly-His, stearoyl-Gly-Gln, stearoyl-Gly-Asn, stearoyl-Gly-Trp, stearoyl-Gly-Lys, stearoyl-Ala-His, stearoyl-Ala-Gln, stearoyl-Ala-Asn, stearoyl-Ala-Trp, stearoyl-Ala-Lys.

Most preferred examples include lauroyl-Gly-His, lauroyl-Ala-His, myristoyl-Gly-His, myristoyl-Ala-His; palmitoyl-Gly-His, palmitoyl-Ala-His; stearoyl-Gly-His, stearoyl-Ala-His.

In the above formula (2), R⁴An aliphatic group having 9 to 23 carbon atoms, and preferable examples thereof include the group represented by R¹The same groups are defined.

In the above formula (2), R⁵～R⁷Each independently represents a hydrogen atom, or may have a carbon atomA branched C1-4 alkyl group having 1 or 2 carbon atoms or- (CH)₂)_n-X group, and R⁵～R⁷At least one of them represents- (CH)₂)_n-a radical X. n represents a number of 1 to 4, and X represents an amino group, a guanidino group or-CONH₂The heterocyclic group may be a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, and the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms. Here, as R⁵～R⁷Preferable specific examples of (A) include the compounds represented by the formula (I) and (II)²And R³The same groups are defined.

Among the compounds represented by the above formula (2), preferable lipid peptides are those composed of a lipid moiety and a peptide moiety (amino acid aggregate moiety) as follows. lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-Gln, myristoyl-Gly-Gly-Asn, myristoyl-Gly-Gly-Trp, myristoyl-Gly-Gly-Lys, myristoyl-Gly-Ala-His, myristoyl-Gly-Ala-Gln, myristoyl-Gly-Ala-Asn, myristoyl-Gly-Ala-Trp, myristoyl-Gly-Ala-Lys, myristoyl-Ala-Gly-His, myristoyl-Ala-Gly-Gln, myristoyl-Ala-Gly-Asn, myristoyl-Ala-Gly-Trp, myristoyl-Ala-Gly-Lys, myristoyl-Gly-Ala-Gly-Asn, myristoyl-Ala-, myristoyl-Gly-His-Gly, myristoyl-His-Gly-Gly, palmitoyl-Gly-Gly-His, palmitoyl-Gly-Gly-Gln, palmitoyl-Gly-Gly-Asn, palmitoyl-Gly-Gly-Trp, palmitoyl-Gly-Gly-Lys, palmitoyl-Gly-Ala-His, palmitoyl-Gly-Ala-Gln, palmitoyl-Gly-Ala-Asn, palmitoyl-Gly-Ala-Trp, palmitoyl-Gly-Ala-Lys, palmitoyl-Ala-Gly-His, palmitoyl-Ala-Gly-Gln, palmitoyl-Ala-Gly-Asn, palmitoyl-Ala-Gly-Trp, palmitoyl-Gly-Gly, Gln, palmitoyl-Ala-Gly-Asn, palmitoyl-Ala-Gly, palmitoyl-Ala-Gly-Lys, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, stearoyl-Gly-Gly-His.

Among these, lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, stearoyl-Gly-Gly-His are most preferable.

In the above formula (3), R⁸An aliphatic group having 9 to 23 carbon atoms, and preferable examples thereof include the group represented by R¹The same groups are defined.

In the above formula (3), R⁹～R¹²Each independently represents a hydrogen atom, or a C1-4 alkyl group which may have a branched chain of C1 or C2, or- (CH)₂)_n-X group, and R⁹～R¹²At least one kind of them represents- (CH)₂)_n-a radical X. n represents a number of 1 to 4, and X represents an amino group, a guanidino group or-CONH₂The heterocyclic group may be a five-membered ring or a six-membered ring, or a fused heterocyclic ring composed of a five-membered ring and a six-membered ring, and the five-membered ring and the six-membered ring may have 1 to 3 nitrogen atoms. Here, as R⁹～R¹²Preferable specific examples of (A) include the compounds represented by the formula (I) and (II)²And R³The same groups are defined.

Among the compounds represented by the above formula (3), examples of suitable lipid peptide-type compounds include lauroyl-Gly-His, myristoyl-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly, stearoyl-Gly-His, and the like.

In the present invention, the content of the lipid peptide compound is, for example, 0.01 to 30% by mass, preferably 0.02 to 10% by mass, and more preferably 0.03 to 5% by mass, based on the total mass of the composition for forming a coating film.

In the present invention, it is more preferable to use at least 1 of the compounds (lipid peptides) represented by the above formulae (1) to (3) or pharmaceutically usable salts thereof as the lipid peptide-based compound, and these compounds may be used alone or in combination of 2 or more.

The composition of the present invention may contain water, alcohol, polyol or a mixed solution thereof in addition to at least 1 of the above-mentioned lipid peptide-based compounds.

Examples of the water include purified water, hard water, soft water, natural water, deep seawater, electrolytic alkaline ionized water, electrolytic acidic ionized water, and cluster water.

The alcohol is a monohydric alcohol, and examples thereof include alcohols having 1 to 6 carbon atoms dissolved in water at an arbitrary ratio, specifically methanol, ethanol, 2-propanol, and isobutanol, and higher alcohols, specifically oleyl alcohol and phenoxyl alcohol.

The polyhydric alcohol is a dihydric or higher alcohol, and examples thereof include propylene Glycol, 1, 3-butanediol, 2-ethyl-1, 3-hexanediol, glycerin, isoprene Glycol, ethylhexanediol, erythrulose, ozonized glycerin, octanediol, ethylene Glycol, (C15-18) diol, (C20-30) diol, glycerin, diethylene Glycol, diglycerin, dithiaoctanediol, DPG, thioglycerol, 1,10-Decanediol (1,10-Decanediol), Decanediol (Decylene Glycol), triethylene Glycol, trimethylmethylol cyclohexanol (チリメチルギドロキシメチルシクロヘキサノール), phytantriol, phenoxypropylene Glycol, 1, 2-butanediol, 2, 3-butanediol, butylethylpropylene Glycol, 1, 2-hexanediol, 1, 6-hexanediol, and the like, Pentylene glycol, methyl propylene glycol, menthane glycol, lauryl glycol, and polypropylene glycol.

In the present invention, when the polyol is contained, the content thereof may be, for example, 1 to 60% by mass, preferably 1 to 30% by mass, based on the total mass of the composition.

In the present invention, when the polyol is contained, the polyol may be used alone or two or more kinds may be used in combination.

[ other additives ]

The composition of the present invention may contain additives that can be generally used as cosmetic additives, quasi-drug additives, and pharmaceutical additives, if necessary.

Examples of the additive components such as physiologically active substances and functional substances to be added to external preparations for skin such as cosmetics, quasi-drugs, and medicines include pigments, oily bases, moisturizers, touch sense improvers, surfactants other than those described above, polymers, thickening/gelling agents, solvents, antioxidants, reducing agents, oxidizing agents, antiseptics, antibacterial agents, antiseptics, chelating agents, pH regulators, acids, bases, powders, inorganic salts, ultraviolet absorbers, skin-whitening agents, vitamins and derivatives thereof, hair growth drugs, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, firming agents, cold-feeling agents, warm-feeling agents, wound healing promoters, irritation-moderators, analgesics, cell activators, plant/animal/microorganism extracts, antipruritics, keratolytic/dissolving agents, skin-growth regulators, skin growth regulators, Antiperspirants, cooling agents, astringents, enzymes, nucleic acids, fragrances, pigments, colorants, dyes, anti-inflammatory agents, anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergic reactions, immunomodulators, anti-infective agents, antifungal agents, and the like.

The content of these other additives may vary depending on the type thereof, but may be, for example, about 0.001 to 20% by mass or about 0.01 to 10% by mass based on the total mass of the composition.

Examples of the pigment include inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide red (red iron oxide) and iron titanate; inorganic brown pigments such as gamma-iron oxide; inorganic yellow pigments such as yellow iron oxide and yellow soil; inorganic black pigments such as iron oxide black and low-valent titanium oxide; inorganic violet pigments such as manganese violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine blue and navy blue; pearlescent pigments such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, and fish scale foil; bulk pigments such as talc, sericite, mica, kaolin, calcium carbonate, magnesium carbonate, silicic anhydride, barium sulfate, and aluminum hydroxide; metal powder pigments such as aluminum powder, copper powder, and gold; surface treating inorganic and metallic powder pigments; organic pigments such as zirconium, barium or aluminum lakes; surface-treated organic pigments and the like are preferable examples.

Examples of the oily base include higher (polyhydric) alcohols such as oleyl alcohol, jojoba alcohol, chimyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols such as benzyl alcohol and derivatives thereof; isostearic acid, behenic acid, 10-undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, diisoheneicosanoic acid, long chain branched fatty acid, dimer acid, hydrogenated dimer acid, and the like; hydrocarbons such as liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α -olefin oligomer, polyisobutylene, hydrogenated polyisobutylene, polybutene, squalane derived from olive, squalene, vaseline, and paraffin wax; candelilla wax, carnauba wax, rice bran wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, wax obtained in the Fischer-Tropsch synthesis process, polyethylene wax, ethylene-propylene copolymer, and other waxes; coconut oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, Chinese chestnut oil, rose hip oil, meadowfoam oil, peach kernel oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter oil, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, grapeseed oil, almond oil (apricot kernel oil), camellia oil and the like; animal fats such as tallow, butter fat, horse fat, egg yolk oil, mink oil, and turtle oil; animal waxes such as spermaceti, lanolin, and atlantic pectoral porgy; lanolin such as liquid lanolin, reduced lanolin, adsorption-purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol acetate, and acetic acid (cetyl/lanolin-based) ester; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl pelargonate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di (cholesteryl/behenyl/octyldodecyl) ester, N-lauroyl-L-glutamic acid di (cholesteryl/octyldodecyl) ester, N-lauroyl-L-glutamic acid di (plant sterols/behenyl/octyldodecyl) ester, acyl sarcosine alkyl esters such as N-lauroyl-L-glutamic acid di (plant sterols/octyldodecyl) ester, N-lauroyl-L-glutamic acid isopropyl ester, cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid ester, phytosterol esters of macadamia oil fatty acid, phytosterol esters of isostearic acid, cholesteryl oleate, glyceryl esters of lauroyl-L-glutamate, N-lauryl-L, Sterol esters such as soft lanolin fatty acid cholesterol ester, hard lanolin fatty acid cholesterol ester, long chain branched fatty acid cholesterol ester, and long chain alpha-hydroxy fatty acid cholesterol ester; lipid complexes such as phospholipid-cholesterol complexes and phospholipid-phytosterol complexes; octyl dodecyl myristate, hexyl decyl myristate, octyl dodecyl isostearate, cetyl palmitate, octyl dodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyl dodecyl neodecanoate, oleyl oleate, octyl dodecyl ricinoleate, octyl dodecyl lanolin fatty acid, hexyl decyl dimethyl octanoate, octyl dodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolate, diethyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl myristate, isopropyl palmitate, diethyl sebacate, isopropyl myristate, methyl palmitate, isopropyl myristate, isopropyl palmitate, isopropyl myristate, isopropyl, Monoalcohol carboxylic acid esters such as diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; hydroxy acid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, etc.; glyceryl trioctoate (glyceryl tri-2-ethylhexanoate), glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic/capric) ate, glyceryl tri (caprylic/capric/myristic/stearic) ate, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol didecanoate, 2-butyl-2-ethyl-1, 3-propanediol dioctanoate, propylene glycol dioleate, pentaerythritol tetraoctanoate, hydrogenated rosin pentaerythritol pentaerythrite, ditrimethylolpropane triethylhexanoate, (isostearic/sebacic) ditrimethylolpropane, glycerol triisostearate, glycerol diisostearate, glycerol tetraoleate, glycerol tetraoctanoate, glycerol tetraoleate, trimethylolpropane tetraoleate, glycerol tetraoleate, Polyhydric alcohol fatty acid esters such as pentaerythritol triethylhexanoate, (hydroxypivalyl hydroxystearate/stearate/abietic acid), diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10 ester, polyglyceryl deca (erucic acid/isostearic acid/ricinoleic acid) 8 ester, (diglyceryl decanoate/sebacic acid) diglyceryl oligoester, ethylene glycol distearate (ethylene glycol distearate), 3-methyl-1, 5-pentanediol dineopentanoate, and 2, 4-diethyl-1, 5-pentanediol dineopentanoate; dimer acids or dimer diol derivatives such as dimer diisopropyl dilinoleate, dimer diisostearyl dilinoleate, dimer dilinoleate di (isostearyl/plant sterol) ester, dimer dilinoleate (plant sterol/behenyl) ester, dimer dilinoleate (plant sterol/isostearyl/cetyl/stearyl/behenyl) ester, dimer dilinoleate ester, dimer dilinoleate hydrogenated rosin condensate, dimer dilinoleate hydrogenated castor oil, and hydroxyalkyl dimer dilinoleate ether; fatty acid alkanolamides such as coconut fatty acid monoethanolamide (cocamide MEA), coconut fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut fatty acid methyl ethanolamide (cocamide methyl MEA); polydimethylsiloxane (dimethylpolysiloxane), high-polymerized polydimethylsiloxane (high-polymerized dimethylpolysiloxane), cyclomethicone (cyclomethicone, decamethylcyclopentasiloxane (also simply referred to as cyclopentylpolysiloxane)), phenyl trimethicone, diphenyl polydimethylsiloxane, phenyl polydimethylsiloxane, stearyloxypropyl dimethylamine, (aminoethylaminopropyl methicone/polydimethylsiloxane) copolymer, amino-modified silicone such as dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, aminopropyl polydimethylsiloxane, and amino-terminated polydimethylsiloxane, polyether-modified silicone such as cation-modified silicone and dimethicone copolyol, polyglycerol-modified silicone, sugar-modified silicone, silicone oil, silicone, Silicones such as carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane-alkylene oxide copolymer, and the like; fluorine-based oils such as perfluorodecane, perfluorooctane and perfluoropolyether are preferable examples.

Examples of the moisturizing agent and the texture improving agent include polyhydric alcohols such as glycerin, trimethylolpropane, pentaerythritol, hexanediol, diglycerin, polyglycerol, diethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymer, and polymers thereof; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as polyglyceryl-10-eicosanedioic acid (eicosanedioic acid/tetradecanedioic acid) and polyglyceryl-10-tetradecanedioic acid; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol; saccharides and derivatives thereof such as glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (modified cyclodextrins such as α -, β -, γ -cyclodextrin, maltosylation, and hydroxyalkylation), β -Glucan (β -Glucan), chitosan, heparin and derivatives thereof, pectin, arabinogalactan, dextrin, dextran (dextran), glycogen, ethyl glucoside, and polymers or copolymers of glucosyl ethyl methacrylate; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucin sulfate, carinin sulfate (charonin sulfate), keratosulfate, dermatan sulfate; tremella extract and tremella polysaccharide; fucoidan; tuberose polysaccharide or natural polysaccharide; organic acids such as citric acid, tartaric acid, and lactic acid, and salts thereof; urea and its derivatives; 2-pyrrolidone-5-carboxylic acid and its sodium salts; amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β -alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and salts thereof; protein peptides such as collagen, fish-derived collagen, atelocollagen (atelocollagen), gelatin, elastin, collagen degradation peptide, hydrolyzed collagen, hydroxypropylammonium chloride-hydrolyzed collagen, elastin degradation peptide, keratin degradation peptide, hydrolyzed keratin, conchiolin degradation peptide, hydrolyzed conchiolin, silk protein degradation peptide, hydrolyzed silk protein, sodium lauroyl-hydrolyzed silk protein, soybean protein degradation peptide, wheat protein degradation peptide, hydrolyzed wheat protein, casein degradation peptide, and acylated peptide, and derivatives thereof; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactobacillus culture solution, yeast extract, eggshell membrane protein, bovine submaxillary gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin and whey; choline chloride, choline phosphate; preferable examples of the ceramide include ceramides such as animal and plant extracts including placenta extract, elastin (エアラスチン), collagen, aloe extract, witch hazel water, luffa water, chamomile extract, licorice extract, comfrey extract, silk extract, filature flower extract, yarrow extract, eucalyptus extract, and sweet clover extract, natural ceramides (type 1, type 2, type3, type 4, type 5, and type 6), hydroxyceramides, pseudoceramides, glycosphingolipids, and ceramide-and-ceramide-containing extracts.

Examples of the surfactant include anionic surfactants, nonionic surfactants, and cationic surfactantsAs the preferable surfactant, an amphoteric surfactant, a polymer surfactant, and the like are preferable. Examples of the anionic surfactant include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, and sodium lauroyl glutamic acid methyl alanine; acyl amino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, di (triethanolamine) palmitoyl aspartate, triethanolamine cocoyl alanine, etc.; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylate; an acyl lactate; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as hardened coconut fatty acid sodium glycerosulfate; alkyl benzene polyoxyethylene sulfates; olefin sulfonates such as sodium alpha-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauryl monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecyl benzenesulfonate and triethanolamine tetradecyl benzenesulfonate; alkyl naphthalene sulfonate; an alkanesulfonate; alpha-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; an alkyl sulfoacetate; alkyl ether phosphate ester salts such as sodium laureth phosphate, sodium dilauryl polyether phosphate, sodium trilauryl polyether phosphate, and sodium monooleyl polyether phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphates;fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicones, phosphoric acid-modified silicones, and sulfuric acid-modified silicones; examples of the nonionic surfactant include various polyoxyethylene alkyl ethers having a polyoxyethylene addition number such as laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), beheneth (polyoxyethylene behenyl ether), isosteeth (polyoxyethylene isostearyl ether), octyldodecyl polyether (polyoxyethylene octyldodecyl ether); polyoxyethylene alkylphenyl ethers; castor oils and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, etc.; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reducing lanolin; polyoxyethylene-polyoxypropylene alkyl ethers such as polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, and polyoxyethylene-polyoxypropylene glyceryl ether; polyoxyethylene-polyoxypropylene glycols; (poly) glycerol polyoxypropylene glycol such as PPG-9 diglyceride; glycerol fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl cocoate fatty acid ester, glyceryl monocottonseed oil fatty acid ester, glyceryl erucate, glyceryl sesquioleate, alpha' -glyceryl pyroglutamate oleate, glyceryl monostearate, malic acid, etc.; polyglyceryl-2 stearate, polyglyceryl-3 stearate, polyglyceryl-4 stearate, polyglyceryl-5 stearate, polyglyceryl-6 stearate, polyglyceryl-8 stearate, polyglyceryl-10 stearate, polyglyceryl-6 distearate, polyglyceryl-10 distearate, polyglyceryl-2 tristearate, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate, isostearic acid, and isostearic acidPolyglycerol-3 ester of fatty acid, polyglycerol-4 ester of isostearic acid, polyglycerol-5 ester of isostearic acid, polyglycerol-6 ester of isostearic acid, polyglycerol-8 ester of isostearic acid, polyglycerol-10 ester of isostearic acid, polyglycerol-2 ester of diisostearic acid (diglycerol diisostearate), polyglycerol-3 ester of diisostearic acid, polyglycerol-10 ester of diisostearic acid, polyglycerol-2 ester of triisostearic acid, polyglycerol-2 ester of tetraisostearic acid, polyglycerol-10 ester of decaisostearic acid, polyglycerol-2 ester of oleic acid, polyglycerol-3 ester of oleic acid, polyglycerol-4 ester of oleic acid, polyglycerol-5 ester of oleic acid, polyglycerol-6 ester of oleic acid, polyglycerol-8 ester of oleic acid, polyglycerol-10 ester of oleic acid, polyglycerol-6 ester of dioleic acid, Polyglyceryl fatty acid esters such as polyglyceryl trioleate-2 ester and polyglyceryl decaoleate-10 ester; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid ester; maltitol moiety fatty acid ester; a maltitol ether; sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, diglycerol sorbitan tetra-2-ethylhexanoate, and the like; sugar derivative partial esters such as sucrose fatty acid ester, methyl glucoside fatty acid ester, and undecylenic acid trehalose; alkyl glucosides such as octyl glucoside; an alkyl polyglycoside; lanolin alcohol; reducing lanolin; polyoxyethylene fatty acid monoesters and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene-propylene glycol fatty acid esters; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate, e.g., polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate; poly(s) are polymerizedPolyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, batyl alcohol and batyl alcohol; a polyol alkyl ether; polyoxyethylene alkyl amines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut fatty acid monoethanolamide (cocamide MEA), coconut fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut fatty acid methyl ethanolamide (cocamide methyl MEA); alkyldimethylamine oxides such as lauryl amine oxide, coco amine oxide, stearyl amine oxide and behenamine oxide; alkyl ethoxy dimethyl amine oxide; polyoxyethylene alkyl mercaptans; silicone nonionic surfactants such as polyether-modified silicones including dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerol-modified silicones, and sugar-modified silicones; examples of the cationic surfactant include alkyltrimethylammonium chlorides such as behenyltrimethylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, and lauryltrimethylammonium chloride; alkyl trimethyl ammonium bromides such as stearyl trimethyl ammonium bromide; dialkyl dimethyl ammonium chlorides such as distearyl dimethyl ammonium chloride and dicocoyl dimethyl ammonium chloride; fatty acid amides such as stearamidopropyldimethylamine and stearamidoethyldiethylamine, and salts thereof; alkyl ether amines such as stearyloxypropyldimethylamine and salts or quaternary salts thereof; fatty acid amide type quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyl dimethyl ammonium, ethyl sulfate lanolin fatty acid aminopropyl ethyl dimethyl ammonium;polyoxyethylene alkylamines and salts or quaternary salts thereof; an alkylamine salt; fatty acid amide guanidine salts; alkyl ether ammonium salts (アルキルエーテルアミンモニウム salt); an alkyltrialkylene glycol ammonium salt; a benzalkonium salt; isooctylphenoxyethoxyethyl dimethyl benzyl ammonium salt; cetyl pyridinium chloridePyridine, etcSalt; imidazolineSalt; alkylisoquinolinesSalt; dialkyl morpholineSalt; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl polydimethylsiloxane and amino-terminated polydimethylsiloxane, cationic-modified silicones, cationic-modified and polyether-modified silicones, and silicone-based cationic surfactants such as amino-modified and polyether-modified silicones; examples of the amphoteric surfactant include N-alkyl-N, N-dimethylamino betaines such as lauryl betaine (lauryl dimethylamino acetic acid betaine); fatty acid amide alkyl-N, N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaines such as sodium N-cocamidoethyl-N-hydroxyethylaminoacetate and sodium N-lauramidoethyl-N-hydroxyethylaminoacetate; alkyl sulfobetaines such as alkyldimethyltaurines; sulfuric acid type betaines such as alkyldimethylaminoethanol sulfate; phosphoric acid betaines such as alkyldimethylaminoethanol phosphate; sphingomyelin such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated yolk phospholipid, and mixtures thereof,Phospholipids such as partially hydrogenated egg yolk phospholipid and hydrogenated egg yolk phospholipid; silicone amphoteric surfactants, and the like; examples of the polymer surfactant include polyvinyl alcohol, sodium alginate, starch derivatives, gum tragacanth, acrylic acid-alkyl methacrylate copolymers; various silicone surfactants are preferred.

Examples of the polymer, thickener and gelling agent include guar gum, locust bean gum, quince seed (クィーンスシード), carrageenan, galactan, gum arabic, tara gum (タラガム), tamarind seed, furcellaran, karaya gum, abelmoschus manihot and quillaja (キ)_ヤラガム), tragacanth gum, pectin, pectic acid and sodium salt, alginic acid and sodium salt, mannan; starch of rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, dextran, gellan gum, chitin, chitosan, agar, brown algae extract, chondroitin sulfate salt, casein, collagen, gelatin, albumin; cellulose and derivatives thereof such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose and salts thereof such as sodium, methylhydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, and cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methyl hydroxypropyl starch, and methyl starch, starch derivatives such as hydroxypropyl trimethyl ammonium chloride starch, and octenyl succinic acid corn starch aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), a vinyl pyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate copolymers such as (methacryloyloxyethylcarboxybetaine/alkyl methacrylate) copolymers and (acrylates/stearyl acrylate/ethyl amine oxide methacrylate) copolymers; (Dimethicone/vinyl Dimethicone) Cross-Linked Polymer, alkyl acrylate/diacetone acrylamide) copolymerizationCompound, alkyl (acrylate/diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymers; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymers; an acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylate copolymers such as polyethylacrylate, carboxyvinyl polymers, salts such as polyacrylic acid and sodium salt thereof, and acrylic acid-methacrylate copolymers; acrylic acid-alkyl methacrylate copolymers; cationized cellulose such as polyquaternium-10, diallyl dimethyl ammonium chloride-acrylamide copolymers such as polyquaternium-7, acrylic acid-diallyl dimethyl ammonium chloride copolymers such as polyquaternium-22, acrylic acid-diallyl dimethyl ammonium chloride-acrylamide copolymers such as polyquaternium-39, acrylic acid-cationized methacrylate copolymers, acrylic acid-cationized methacrylamide copolymers, acrylic acid-methyl acrylate-methacrylamidopropyl trimethyl ammonium chloride copolymers such as polyquaternium-47, and choline chloride methacrylate polymers; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar gum hydroxypropyl trimethyl ammonium chloride and the like; a polyethyleneimine; a cationic polymer; copolymers such as a 2-methacryloyloxyethyl phosphorylcholine polymer such as polyquaternium-51 and a butyl methacrylate copolymer; high molecular weight emulsions such as acrylic resin emulsions, polyethylacrylate emulsions, polyalkylacrylate emulsions, polyvinyl acetate resin emulsions, natural rubber latexes, synthetic latexes, and the like; cellulose nitrate; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic acid-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; preferred examples thereof include silica, fumed silica (ultrafine silica), magnesium aluminum silicate, sodium magnesium silicate, metal soap, metal dialkylphosphate, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, and fructooligosaccharide fatty acid ester. Among the above examples, cellulose and derivatives thereof, alginic acid and salts thereof, polyvinyl alcohol, hyaluronic acid and salts thereof are preferableOr collagen.

Examples of the solvent include lower alcohols such as ethanol, 2-propanol (isopropanol), butanol, and isobutanol; glycols such as propylene glycol, diethylene glycol, dipropylene glycol, and isoamyl glycol; glycol ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and dipropylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxy ethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methyl pyrrolidone; toluene and the like are preferred examples.

Examples of the antioxidant include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfite such as sodium bisulfite; thiosulfate salts such as sodium thiosulfate; a metabisulfite salt; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred examples.

Preferable examples of the reducing agent include thioglycolic acid, cysteine, and cysteamine.

Preferred examples of the oxidizing agent include hydrogen peroxide water, ammonium persulfate, sodium bromate, and percarbonic acid.

Examples of the preservatives, antibacterial agents and bactericides include hydroxybenzoic acids such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate and butyl parahydroxybenzoate, and salts and esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolineUrea; dehydroacetic acid and salts thereof; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; trichloro-sym-diphenylurea, 1-oxo-2-mercapto-zinc pyridinium, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine gluconate, halocarban, hexachlorophene, 4-isopropyl tropolone; phenol, isopropylphenol, cresol, thymol, p-chlorophenol, phenylphenol, sodium phenylphenol, and other phenols; preferred examples thereof include phenylethyl alcohol, photosensitizers, antibacterial zeolite, and silver ions.

Examples of the chelating agent include ethylenediaminetetraacetate salts (ethylenediaminetetraacetate salts) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4 Na; hydroxyethylethylenediamine triacetate such as HEDTA3 Na; pentetate (diethylenetriamine pentaacetate); phytic acid; phosphonic acids such as hydroxyethylidene diphosphonic acid and salts such as sodium salts thereof; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, tartaric acid as preferred examples.

Examples of the pH adjuster, acid, and base include ascorbic acid, citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1, 3-propanediol, 2-amino-2-hydroxymethyl-1, 3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

Examples of the powder include mica (マイカ), talc, kaolin, sericite, montmorillonite, kaolinite, mica (mica), muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcium phosphate such as calcined calcium sulfate or tricalcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soap (e.g., zinc myristate, calcium palmitate or aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine particles and ultrafine particles of titanium oxide, zinc oxide, fine particles and ultrafine particles of zinc oxide, alumina, silica, fumed silica (ultrafine particle silica), Inorganic powders such as titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder, inorganic powders of various sizes and shapes such as gold, silver, platinum and aluminum, and hydrophobized or hydrophilized powders obtained by treating them with various surface-treating agents such as organosilicon (e.g., hydrosilicone) and cyclic hydrosilicone, or other silanes or titanium coupling agents; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminate powder, polyethylene terephthalate-aluminum-epoxy laminate powder, and the like, organic powders and surface-treated powders of various sizes and shapes such as urethane powder, silicone powder, Teflon (registered trademark) powder, and the like, and organic-inorganic composite powders are preferable examples.

Examples of the inorganic salts include salts containing sodium chloride such as table salt, crude salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride and ammonium chloride; sodium sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, ferric sulfate, and copper sulfate; preferred examples thereof include sodium phosphates such as monosodium phosphate, disodium phosphate and trisodium phosphate, potassium phosphates, calcium phosphates and magnesium phosphates.

Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers such as p-aminobenzoic acid, monoglyceride of p-aminobenzoic acid, ethyl N, N-dipropyloxy-p-aminobenzoate, ethyl N, N-diethoxy-p-aminobenzoate, ethyl N, N-dimethyl-p-aminobenzoate, butyl N, N-dimethyl-p-aminobenzoate, and methyl N, N-dimethyl-p-aminobenzoate; anthranilic acid series such as N-acetyl-o-aminobenzoic acid homomenthyl esterAn ultraviolet absorber; salicylic acid-based ultraviolet absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropyl alcohol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2, 5-diisopropyl cinnamate, ethyl-2, 4-diisopropyl cinnamate, methyl-2, 4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isopentyl-p-methoxy cinnamate, 2-ethylhexyl-p-methoxy cinnamate (octyl p-methoxycinnamate), 2-ethoxyethyl-p-methoxy cinnamate (cinnamate ester), cyclohexyl-p-methoxy cinnamate, ethyl-alpha-cyano-beta-phenyl cinnamate, 2-ethylhexyl-alpha-cyano-beta-phenyl cinnamate (octocrylene), Cinnamic acid ultraviolet absorbers such as glyceryl mono-2-ethylhexanoyl-di-p-methoxycinnamate, ferulic acid and derivatives thereof; 2, 4-dihydroxybenzophenone, 2 '-dihydroxy-4-methoxybenzophenone, 2' -dihydroxy-4, 4 '-dimethoxybenzophenone, 2', benzophenone-based ultraviolet absorbers such as 4,4 ' -tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzophenone-3), 2-hydroxy-4-methoxy-4 ' -methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4 ' -phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octyloxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3- (4' -methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzeneAzole; 2, 2' -hydroxy-5-methylphenylbenzotriazole; 2- (2 '-hydroxy-5' -tert-octylphenyl) benzotriazole; 2- (2 '-hydroxy-5' -methylphenylbenzotriazole, dibenzylazine (ジベンザラジン), diantimomethane, 5- (3, 3-dimethyl-2-norbornylidene) -3-pentan-2-one, dibenzoylmethane derivatives such as 4-tert-butylmethoxydibenzoylmethane, octyltriazone, urocanic acid derivatives such as urocanic acid and ethyl urocanic acid, 2- (2 '-hydroxy-5' -methylphenyl) benzotriazole, 1- (3, 4-bis-benzoylmethaneHydantoin derivatives such as methoxyphenyl) -4, 4-dimethyl-1, 3-pentanedione, 2-ethylhexyl dimethoxybenzylidenedioxoimidazolidinepropionate, phenylbenzimidazolesulfonic acid, terephthalylidene dicamphor sulfonic acid, cresols trozole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives are preferable examples.

Examples of the whitening agent include hydroquinone glycosides such as arbutin and α -arbutin, and esters thereof; ascorbic acid phosphate ester salts such as ascorbic acid, sodium ascorbyl phosphate, and magnesium ascorbyl phosphate, ascorbic acid fatty acid esters such as ascorbyl tetraisopalmitate, ascorbic acid alkyl ethers such as ascorbyl ethyl ether, ascorbyl glucosides such as ascorbic acid-2-glucoside, and ascorbic acid derivatives such as fatty acid esters thereof, ascorbyl sulfate, and tocopheryl ascorbyl phosphate; plant extracts such as kojic acid, ellagic acid, tranexamic acid and derivatives thereof, ferulic acid and derivatives thereof, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, cacumen Tamaricis extract, and saxifrage extract are preferable examples.

Examples of the vitamins and derivatives thereof include vitamin a compounds such as retinol, retinyl acetate, and retinyl palmitate; nicotinic acids such as thiamine hydrochloride, thiamine sulfate, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dicaprylate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamine, folic acid, nicotinamide, benzyl nicotinate, and vitamin B groups such as choline; ascorbic acids and salts thereof such as sodium ascorbate; vitamin D; vitamin E compounds such as alpha, beta, gamma, delta-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate ester salts such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, stearic acid ascorbate, palmitic acid ascorbate, dipalmitate ascorbate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside, fatty acid esters thereof, and ascorbic acid derivatives such as tocopherol phosphate ascorbate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate and the like, tocotrienols, and other various vitamin derivatives are preferable examples.

Examples of the hair-growing agent, blood circulation promoter and stimulant include swertia japonica Makino extract, capsicum tincture, ginger extract, cantharides tincture and other plant extracts and tinctures; capsaicin, vanillylnonanoate, zingerone, ichthammol, tannic acid, borneol, cyclanoate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, gamma-oryzanol, vitamin E and tocopherol nicotinate, derivatives such as tocopherol acetate, gamma-oryzanol, nicotinic acid and nicotinamide, benzyl nicotinate, inositol hexanicotinate, derivatives such as nicotinol, allantoin, photosensitizer 301, photosensitizer 401, carpronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, minoxidil as preferred examples.

Preferred examples of the hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, prednisone, and the like.

Examples of other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold-feeling agents, warm-feeling agents, wound healing promoters, irritation moderators, analgesics, and cell activators include retinoids, and tocopherol retinoic acid esters; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acids, salicylic acid and glycosides and esters thereof, α -or β -hydroxy acids such as hydroxydecanoic acid, long-chain α -hydroxy fatty acid, and long-chain α -hydroxy fatty acid cholesteryl ester, and derivatives thereof; gamma-aminobutyric acid, gamma-amino-beta-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like and derivatives thereof; antioxidant and active oxygen scavenger such as coenzyme Q10, carotene, lycopene, astaxanthin, lutein, alpha-lipoic acid, platinum nanocolloid, and fullerene; catechins; flavonoids such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, proanthocyanidin (プロトアントシアニジン), chlorogenic acid, and apple polyphenol; rutin and glucoside derivatives; derivatives such as hesperidin and glycosides; a lignan glycoside; glycyrrhrizae radix extract related substances such as glabridin, glabrene, Liquorice root pavilion, and isoliquiritigenin; lactoferrin; shogaol, gingerol; perfume materials such as menthol and cedrol and derivatives thereof; capsaicin, vanillin, and the like and derivatives; insect repellents such as diethyltoluamide; a complex of a physiologically active substance and a cyclodextrin is a preferred example.

Examples of the plant, animal and microorganism extracts include iris extract, Salicomia Herbacea extract, Thujopsis dolabrata extract, Asparagus officinalis extract, avocado extract, hydrangea vulgaris extract, apricot extract, hollyhock extract, Amur senecio flos extract, aloe extract, apricot extract, almond extract, ginkgo extract, Artemisia capillaris extract, fennel extract, turmeric extract, oolong tea extract, bearberry leaf extract, dog rose fruit extract, Echinacea purpurea extract, Isodon japonicus extract, Scutellaria baicalensis extract, barberry extract, Coptis chinensis extract, barley extract, Korean ginseng extract, Hypericum erectum extract, wild sesame extract, Japanese mangosteen flower extract, water fennel extract, orange extract, seawater dried product, seaweed extract, persimmon leaf extract, pyracantha extract, hydrolyzed elastin, hydrolyzed wheat flour, and the like, Hydrolyzed silk protein, kudzu root extract, chamomile extract, oil-soluble chamomile extract, carrot extract, mugwort extract, wild oat extract, roselle extract, licorice extract, oil-soluble licorice extract, kiwi fruit extract, chia (キオウ) extract, agaric extract, cinchona extract, cucumber extract, tung leaf extract, guanosine, guava extract, sophora flavescens (クジン) extract, gardenia extract, phyllostachys pubescens extract, sophora flavescens (クララ) extract, walnut extract, chestnut extract, grapefruit extract, clematis chinensis extract, black rice extract, muscovado extract, black vinegar, chlorella extract, mulberry extract, gentiana lutea root extract, geranium nepalense extract, black tea extract, yeast extract, magnolia bark extract, coffee extract, burdock extract, mugwort extract, wild oat extract, roselle extract, hibiscus sabdariffalo extract, licorice extract, black sesame extract, Rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen, cowberry fruit extract, asarum herb extract, bupleurum root extract, umbilical cord extract, saffron extract, sage extract, soapwort extract, bamboo extract, hawthorn extract, coriander extract, zanthoxylum extract, shiitake mushroom extract, rehmannia root extract, Japanese sage extract, perilla extract, linden extract, dropwort extract, twinleaf bean extract, peony extract, ginger extract, calamus extract, white birch extract, tremella extract, horsetail extract, stevia rebaudiana fermented product, Chinese tamarisk extract, ivy extract, Japanese hedyotis extract, American hawthorn extract, Sambucus nigra extract, Achillea millefolium extract, Mentha piperita extract, sage extract, mallow extract, Japanese milkvetch extract, Japanese milkwort extract, Ligusticum wallichii extract, swertia japonica extract, cortex mori extract, rheum officinale extract, soybean extract, jujube extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cogongrass rhizome extract, dried orange peel extract, tea tree oil, sweet tea extract, pepper extract, angelica sinensis extract, calendula officinalis extract, peach kernel extract, orange peel extract, houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, ophiopogon root extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, wall grass extract, caraway extract, bisabolol, japanese cypress extract, bifidobacterium extract, loquat extract, coltsfoot extract, tussilago stem extract, tussilago farfarfara extract, thyme extract, dandelion extract, lichen extract, peach kernel extract, orange peel extract, houttuynia cordata extract, tomato extract, natto extract, carrot, Poria cocos extract, butcher's broom extract, grape seed extract, propolis, towel gourd extract, safflower extract, mint extract, tilia miqueliana extract, peony extract, hop extract, rose extract, pine extract, aesculus hippocastanum extract, lotus extract, soapberry extract, melissa extract, nemacy extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, orange extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, aspalathus linearis extract, ganoderma extract, lettuce extract, lemon extract, forsythia extract, astragalus sinicus extract, rose extract, rosemary extract, chamomile extract, royal jelly extract, honey locust bean, An extract such as sanguisorba officinalis extract is preferable.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance P inhibitor, and the like.

Examples of the exfoliating or dissolving agent include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, and the like.

Examples of the antiperspirant include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc p-phenolsulfonate.

Examples of the cooling agent include menthol and methyl salicylate.

Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, and the like.

Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease.

Examples of the nucleic acids include ribonucleic acid and a salt thereof, deoxyribonucleic acid and a salt thereof, and disodium adenosine triphosphate.

Examples of the perfume include acebiotene, amyl cinnamaldehyde, allyl amyl glycolate, β -ionone, ambergris ketone (Iso E Super), isobutyl quinoline, iris oil, irilone, indole, ylang oil, undecanal, undecenal, γ -undecanolactone, estragole, eugenol, oak moss, red myrrh balm, orange oil, eugenol, nerarin, galaxolide (ガラクソリツド), carvacrol, L-carvone, camphor, キャノン, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranonitrile, isobornyl acetate, geranyl acetate, dimethylbenzyl methyl acetate, styryl acetate, cedryl acetate, terpinyl acetate, p-tert-butylcyclohexyl acetate, bergamoyl acetate, benzyl acetate, linalyl acetate, isoamyl salicylate, and mixtures thereof, Benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmonate, cis-jasmone, citral, citronellol, citronellal, cassia oil, 1, 8-cineole, cinnamaldehyde, styrax, cedarwood oil, cedrene, cedarwood brain, celery seed oil, thyme oil, damascone, thymol, tuberose oil, decanal, decalactone, terpineol, gamma-terpinene, 2, 4-dimethyl-3-cyclohexene-1-carbaldehyde (トリプラール, tripal), nerol, nonanal, 2, 6-nonadienol, nonalactone, patchouli alcohol, vanilla oil, vanillin, basil oil, patchouli oil, hydroxycitronellal oil, alpha-pinene, patchouli oil, alpha-pinene, patchouli alcohol, patchouli oil, alpha-pinene, patchouli oil, synthetic and natural flavors such as menthone, phenethyl alcohol, phenyl acetaldehyde, orange leaf oil, hexyl cinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol, peppermint oil, pepper oil, piperonal, bergamot oil, benzyl benzoate, borneol, pinus massoniana, muscone, methyl nonyl acetaldehyde, gamma-methyl ionone, menthol, L-menthone, eucalyptus oil, beta-ionone, orange oil, lavender oil, D-limonene, linalool, lyral (リラール, lyral), lilial, lemon oil, rose absolute, rose ether, rose oil, rosemary oil, various essential oils, and various blended flavors are preferred examples.

Examples of the pigment, colorant and dye include brown No. 201, Black No. 401, purple No. 201, purple No. 401, blue No. 1, blue No. 2, blue No. 201, blue No. 202, blue No. 203, blue No. 204, blue No. 205, blue No. 403, blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Pigments such as Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, Red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202-1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406, yellow 407, yellow 5, etc.; acid red 14 and other acid dyes; basic dyes such as ochre Brown (Arianor Sienna Brown), bright Red (Arianor Madder Red), Steel Blue (Arianor Steel Blue), grass Yellow (Arianor strong Yellow); nitro dyes such as HC Yellow 2(HC Yellow 2), HC Yellow 5(HC Yellow 5), HC Red (HC Red)3, 4-hydroxypropylamino-3-nitrophenol, N' -bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2(HC Blue 2), and basic Blue 26; a disperse dye; anthraquinones such as astaxanthin and alizarin, natural pigments and dyes such as anthocyanins, beta-carotene, pigments (カテナール), capsanthin, chalcones, carthamin, quercetin, crocetin, crocin, chlorophyll, curcumin, cochineal, shikonin, and other naphthoquinones, bixin, flavonoids, betacyanin (ベタシアニジン), henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2, 5-diamine, o-aminophenol, m-aminophenol, p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2, 6-diaminopyridine and the like, and salts thereof; auto-oxidation dyes such as indoline; dihydroxyacetone is a preferred example.

Examples of the anti-inflammatory agent and the anti-inflammatory agent include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, 4-isopropyltropolone, guaiazulene, allantoin, indomethacin, ketoprofen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercept, zinc oxide, hydrocortisone acetate, prednisone, diphenhydramine hydrochloride, and chlorphenamine maleate; preferred examples of the plant extract include peach leaf extract and wormwood leaf extract.

Examples of the antiasthmatic, antiallergic, and immunomodulator include aminophylline, theophylline, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, cromolyn sodium (インタール), β 2 stimulators (formoterol, salmeterol, salbutamol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium (チオトロピウム), ipratropium (イプラトロピウム), dextromethorphan, dimemorfan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, mequitazine, tacrolimus, cyclosporine, sirolimus, methotrexate, cytokine modulators, interferon, omalizumab, and protein/antibody preparations.

Preferred examples of the antiinfective agent and antifungal agent include oseltamivir, zanamivir, and itraconazole. Further, known Cosmetic ingredients, pharmaceutical ingredients, food ingredients, and The like may be contained in known combinations and mixing ratios/amounts, such as Cosmetic raw material standards, Cosmetic category mixed Ingredient standards, contents of The names of components of The japan Cosmetic industry association, INCI dictionary (The International Cosmetic Ingredient dictionary and Handbook), quasi-drug raw material standards, japanese pharmacopoeia, drug additive standards, ingredients described in food additive official books, and The like, and ingredients described in japanese and various foreign patent publications and patent laid-open publications (including The official gazettes and re-official gazettes) belonging to The classification of The International patent classification IPC of a61K7 and a61K 8.

[ method for producing composition for Forming coating film ]

The composition for forming a coating film of the present invention can be produced, for example, by mixing at least 1 lipid peptide compound, water, and, if necessary, other components while heating, stirring, and then leaving to stand and cool.

[ method for producing coating film ]

The present invention also relates to a method for producing a coating film, which is characterized by using the above composition for forming a coating film.

The method for producing the coating is not particularly limited as long as the coating can be produced, and examples thereof include a method in which the coating-forming composition is applied to a coating object and then dried by natural drying, heat drying, or the like.

Examples

The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to the following examples.

The reagents used in the synthesis examples were commercially available as shown below, and the following instruments were used for analysis of each compound synthesized.

< reagent >

Methanol: kanto chemical Co., Ltd (Special grade)

Isopropyl alcohol: kanto chemical Co., Ltd (grade 1)

Toluene: kanto chemical Co., Ltd (grade 1)

Acetic acid: kanto chemical Co., Ltd (grade 1)

Glycine methyl ester hydrochloride: tokyo chemical industry Co Ltd

L-histidine: tokyo chemical industry Co., Ltd, egg fermentation バイオ Co., Ltd

Sodium methoxide 28% methanol solution: heguang pure chemical industry Co., Ltd (28% sodium methoxide methanol solution)

Sodium carbonate: pure chemical company (level 1)

Hydrochloric acid: kanto chemical Co., Ltd (grade 1)

Acetonitrile: kanto chemical Co., Ltd (Special grade)

And (3) ISTA: 2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoic acid [ ファインオキソコール (registered trademark) isostearic acid, manufactured by Nissan chemical industries, Ltd ]

2-heptylundecanoic acid: [ products of daily chemical industry ]

Thionyl chloride: tokyo chemical industry Co Ltd

Acetone: kanto chemical Co., Ltd (grade 1)

Tetrahydrofuran: kanto chemical Co., Ltd (grade 1)

Ethyl acetate: kanto chemical Co., Ltd (grade 1)

N, N-Dimethylformamide (DMF): kanto chemical Co., Ltd (grade 1)

< analytical apparatus >

NMR: JNM-ECP300 (manufactured by Japan electronic Co., Ltd.)

LC-MS：Waters ACQUITY

A pH meter: メトラートレド products made

Synthetic example 1: synthesis of lipid peptide-type Compound (N-palmitoyl-Gly-His) ]

In a 500mL four-necked flask, 14.2g (91.6mmol) of L-histidine, 30.0g (91.6mmol) of N-palmitoyl-Gly-methyl, and 300g of toluene were placed, and 35.3g (183.2mmol) of 28% methanol solution of sodium methoxide as a base was added, followed by heating in an oil bath to 60 ℃ and further stirring for 1 hour. Then, the oil bath was removed, and the solution was allowed to cool to 25 ℃ and reprecipitated in 600g of acetone, followed by filtration. The solid obtained here was dissolved in a mixed solution of 600g of water and 750g of methanol, and then 30.5mL (183.2mmol) of 6N hydrochloric acid was added thereto to neutralize the solution to precipitate a solid, followed by filtration. Next, the obtained solid was dissolved in a mixed solution of 120g of tetrahydrofuran and 30g of water at 60 ℃, 150g of ethyl acetate was added, and the mixture was cooled from 60 ℃ to 30 ℃. Then, the precipitated solid was filtered. The obtained solid was further dissolved in a solvent of 120g of tetrahydrofuran and 60g of acetonitrile, heated to 60 ℃, stirred for 1 hour, cooled, and filtered. The solid obtained here was washed with 120g of water, filtered, and dried under reduced pressure to obtain 26.9g (yield 65%) of N-palmitoyl-Gly-His free form (hereinafter, also abbreviated as Pal-GH) as white crystals.

[ Synthesis example 2: synthesis of lipopeptide-type Compound (2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoylglycylhistidine)

(1) Synthesis of methyl 2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoyl glycinate

A100 mL four-necked flask was charged with ISTAC 20.0g (70.3mmol), DMF154mg, and toluene 20.0g, and the temperature was adjusted to 0 ℃. After 8.78g (73.8mmol) of thionyl chloride was added dropwise over 15 minutes, the temperature was slowly raised to 30 ℃. After stirring at 30 ℃ for 2 hours, 20.0g of toluene was added. The temperature was raised to 50 ℃ and 20g of toluene was distilled off under reduced pressure to remove thionyl chloride, and this operation was repeated 2 times (acid chloride solution).

Separately from the reaction vessel, 40.0g of ion-exchanged water, 11.5g (91.4mmol) of glycine methyl ester hydrochloride and 80.0g of toluene were put in a 500mL four-necked flask, and 8.6g (80.9mmol) of sodium carbonate as a base and 60.0g of ion-exchanged water were put in the flask and stirred. Then, the acid chloride solution was added dropwise thereto at a reaction temperature of 25. + -. 5 ℃ over 1 hour, and after stirring at 25 ℃ for 3 hours, 200.0g of 10% saline was added thereto, followed by liquid separation at 60 ℃. 160.0g of toluene was added to the obtained organic layer, and azeotropic dehydration was carried out to obtain 24.5g of methyl 2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoyl glycinate (yield 98%).

(2) Synthesis of 2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoyl glycyl histidine

In a 500mL four-necked flask, 10.7g (68.9mmol) of L-histidine and 49.0g of toluene were charged, 12.6g (65.5mmol) of a 28% methanol solution of sodium methoxide as a base was added dropwise, and then 24.5g (68.9mmol) of methyl 2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoyl glycinate obtained in Synthesis example 2(1) was charged together with 9.8g of methanol and the temperature was raised to 70 ℃. Then, 10.0g (51.7mmol) of 28% methanol solution of sodium methoxide as a base was added dropwise thereto, and stirring was continued at about 70 ℃ for 3 hours. After completion of the reaction, acetic acid (5.0 g, 82.6mmol) was added to adjust the pH, the pH was adjusted to 7, and ion-exchanged water (122.5 g) and isopropanol (49.0 g) were added to separate the mixture at 60 ℃. To the obtained aqueous layer was added 13.8g (82.7mmol) of 6N hydrochloric acid, and 24.5g of methanol was added to carry out reprecipitation in 489.8g of acetonitrile. The obtained slurry was filtered, and a wet product was dissolved in methanol, and then charged into activated carbon (purpose-made aigret) (japanese: purpose-made aigret) 4.9g, stirred for 1 hour, then subjected to filtration separation, and again subjected to reprecipitation in acetonitrile 489.8 g. The obtained wet product was dried under reduced pressure at 60 ℃ to obtain 26.6g (yield 86%) of 2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoylglycylhistidine (hereinafter, also referred to as FO-GH).

·¹H-NMR(300MHz，DMSO-d₆，δppm)：8.02(2H，m)，7.55(1H，s)，6.80(1H，s)，4.38(1H，m)，3.68(2H，m)，2.88(2H，m)，1.94(1H，m)，1.51(4H，m)，1.12(3H，m)，0.87(27H，m)

·MS(ESI)m/z：479.29(M+H⁺)

[ Synthesis example 3: synthesis of lipid peptide-type Compound (2-heptylundecylglycylhistidine) ]

(1) Synthesis of 2-heptylundecylglycin methyl ester

24.1g (96% yield) of glycine methyl 2-heptylundecanoate was obtained in the same manner as in Synthesis example 2(1), except that 2-heptylundecanoate was used as the starting material.

(2) Synthesis of 2-heptylundecylglycylhistidine

23.1g (yield 86%) of 2-heptylundecaoylglycylhistidine (hereinafter, also referred to as IS-Ste-GH) was obtained in the same manner as in Synthesis example 2(2) except that glycine methyl 2-heptylundecaylglycinate was used instead of 2- (4, 4-dimethylpentan-2-yl) -5,7, 7-trimethyloctanoylglycine methyl ester.

·¹H-NMR(300MHz，DMSO-d₆，δppm)：8.07(1H，t，J＝6.0Hz)，8.04(1H，d，J＝7.5Hz)，7.57(1H，s)，6.82(1H，s)，4.39(1H，q，J＝7.5Hz)，3.68(2H，m)，2.28(2H，m)，2.16(1H，m)，1.42(2H，m)，1.21(26H，m)，0.85(3H，m)

·MS(ESI)m/z：479.18(M+H⁺)

Preparation example 1: preparation of premix

Pal-GH, stearic acid as an additive, 1, 2-hexanediol, polyoxyethylene lauryl ether (manufactured by Sun light ケミカルズ Co., Ltd.), and water were added to a 300mL beaker in the proportions shown in Table 1, and the mixture was heated and stirred at a liquid temperature of 80 ℃ and 200rpm to prepare a homogeneous solution. While stirring, the mixture was cooled, and when the liquid temperature became 60 ℃, it was allowed to stand and cool, thereby preparing an ES-01 premix.

[ Table 1]

TABLE 1 composition of ES-01 premix

Become intoIs divided into	Composition of (wt％)
		Pal-GH	10.0
HardFat and oilAcid(s) ﹡1	1.0
		1, 2-hexaneIIAlcohol(s) ﹡2	4.0
Poly(s) are polymerizedOxygen gasSecond stepAlkene(s)Moon cakeSweet osmanthusBase ofEther compounds﹡3	8.0
		Pure water	77.0

﹡ 1: kao (kava) (trade name: s-98]

﹡ 2: manufactured by Kabushiki Kaisha アイ, ティー, オー

﹡ 3: sunlight ケミカルズ (manufactured by ltd.): POE (4.2) lauryl ether

EXAMPLE 1 gelation test and gel morphology observation

Propylene glycol alginate, POE60 hydrogenated castor oil, mineral oil and purified water were added to a 300mL beaker according to Table 2, and heated and stirred at 80 ℃. Stirring was carried out at 200rpm using LABORATORY HIGH MIXER manufactured by アズワン (strain). Next, ES-01 premix heated to 80 ℃ was added thereto, and further heated and stirred for 5 minutes. After the completion of the heating and stirring, the mixture was stirred and cooled until the liquid temperature became about 50 ℃. The gel formation was confirmed by the test tube inversion method, and the state where the fluidity of the dispersion was lost and the liquid did not flow down even when the beaker was inverted was judged to be gelation.

The obtained gel was allowed to stand at 10mg/cm²The coating solution was applied to a biological skin (manufactured by Bioskin ビューラックス Co., Ltd.) and a Scanning Electron Microscope (SEM) [ Miniscope (registered trademark) TM3000 (manufactured by Hitachi ハイテクノロジーズ Co., Ltd.) ]was used]The morphology of the gel after coating was observed. Fig. 1 shows an observation image of a sample immediately after being set on a scanning electron microscope and a sample dried by being set on a scanning electron microscope for a predetermined time.

Comparative example 1 gelation test

Propylene glycol alginate, POE60 hydrogenated castor oil, mineral oil and purified water were added to a 300mL beaker according to Table 2, and heated and stirred at 80 ℃. Stirring was carried out at 200rpm using LABORATORY HIGH MIXER manufactured by アズワン (strain). After the heating and stirring are completed, the mixture is stirred and cooled until the liquid temperature becomes about 50 ℃.

[ Table 2]

TABLE 2

Become intoIs divided into	Practice ofExample (b) 1	Ratio ofComparative example 1
			Algae (Saccharum sinensis Roxb.)Acid(s)C3IIAlcohol(s)Esters ﹡4	0.2g	0.2g
POE60 hydrogenationGrate for cookingHemp (flax)Oil ﹡5	2.5g	2.5g
			Mineral substanceOil ﹡6	5.0g	5.0g
Pure water	82.3g	92.3g
			ES-01 premixingMaterial	10.0g	Is free of
Total amount of	100.0g	100.0g
			Combination ofArticle (A)Status of state	Coagulation of waterGlue	Liquid for treating urinary tract infectionBody

﹡ 4: (Strain) キミカ HV rating

﹡ 5: manufactured by sunlight ケミカルズ Kabushiki Kaisha

﹡ 6: manufactured by Kabushiki Kaisha ピノア

[ example 2]

Propylene glycol alginate, POE60 hydrogenated castor oil, and purified water were added to a 300mL beaker according to Table 3, and heated and stirred at 80 ℃. Stirring was carried out at 200rpm using LABORATORY HIGH MIXER manufactured by アズワン (strain). Next, ES-01 premix heated to 80 ℃ was added thereto, and further heated and stirred for 5 minutes. After the completion of the heating and stirring, the mixture was stirred and cooled until the liquid temperature became about 50 ℃. The gel formation was confirmed by the test tube inversion method, and the state where the fluidity of the dispersion was lost and the liquid did not flow down even when the beaker was inverted was judged to be gelation.

Comparative example 2

Propylene glycol alginate, POE60 hydrogenated castor oil, and purified water were added to a 300mL beaker according to Table 3, and heated and stirred at 80 ℃. Stirring was carried out at 200rpm using LABORATORY HIGH MIXER manufactured by アズワン (strain). After the heating and stirring are completed, the mixture is stirred and cooled until the liquid temperature becomes about 50 ℃.

[ Table 3]

TABLE 3

Become intoIs divided into	Practice ofExample (b) 2	Ratio ofComparative example 2
			Algae (Saccharum sinensis Roxb.)Acid(s)C3IIAlcohol(s)Esters ﹡4	0.2g	0.2g
POE60 hydrogenationGrate for cookingHemp (flax)Oil ﹡5	2.5g	2.5g
			Pure water	87.3g	97.3g
ES-01 premixingMaterial	10.0g	Is free of
			Total amount of	100.0g	100.0g
Combination ofArticle (A)Status of state	Coagulation of waterGlue	Liquid for treating urinary tract infectionBody

﹡ 4: (Strain) キミカ HV rating

﹡ 5: manufactured by sunlight ケミカルズ Kabushiki Kaisha

Example 3 and comparative example 3 measurement of intensity of reflected light

The gel obtained in example 2 or the liquid of comparative example 2 was weighed according to table 4, and squalane was added thereto. A spatula was used to obtain a uniform thickening or liquid after addition.

Further, the thickener of example 3 or the liquid of comparative example 3 shown in Table 4 was adjusted to 10mg/cm²The coating was applied to a biological skin (manufactured by Bioskin ビューラックス Co., Ltd.) and dried in a thermostat at 35 ℃. Using variable angle luminosityGP-5 (manufactured by color technology research, Inc.) was measured, and the intensity of 30 ℃ reflected light was measured when the incident light was 30 ℃.

In addition, the appearance photograph and SEM image of example 3 and comparative example 3 are shown in fig. 2 and 3, respectively.

[ Table 4]

TABLE 4

Become intoIs divided into	Practice ofExample (b) 3	Ratio ofComparative example 3
			Practice ofExample (b) 2	0.5g
Ratio ofComparative example 2		0.5g
			CornerSqualane ﹡7	0.1g	0.1g
Combination ofArticle (A)Outer coverWatch with	IncreaseThick foodArticle (A)	Liquid for treating urinary tract infectionBody
			At-30 DEG belowIs/are as followsInverse directionShooting deviceLight (es)Strength of	47.0	95.8

﹡ 7: manufactured by sunlight ケミカルズ Kabushiki Kaisha

According to the results shown in table 4, the coating obtained by the composition of the present invention has about half of the intensity of reflected light (example 3) as compared with the coating obtained by the composition containing no lipid peptide-type compound (comparative example 3).

The composition for forming a coating film of the present invention can form a coating film capable of suppressing reflection of light.

Example 4 and comparative example 4 moisture test of shampoo

Phase A was weighed into a 300mL tall beaker according to Table 5. On the other hand, ES-01 premix was weighed against purified water heated to 70 ℃ and dissolved by heating in the same manner to prepare phase B. To phase A, heated to 70 deg.C, phase B was added. Then, stirring and cooling were carried out until the liquid temperature became about 40 ℃.

[ Table 5]

TABLE 5

*8: preparation of Zhongzisu ァミソフト CS-11

*9: preparation of Zhongzisu アミライト GCK-11

*10: 礻 オスコ - プ CTS-25

*11；アンホレツクス

*12：アミコールCDE-1

*13: 1, 3-butanediol manufactured by strain アイ·テイー·オー

*14: pure chemical system

*15: MERQUAT(TM)550 POI.YMER, manufactured by Lubricator, Japan

*16: tokyo chemical industry products

A bundle of human hair (black hair, 1g, 10cm) (manufactured by Fujikushisha) was reciprocated 10 times by using "キクロン" (company name) sponge, and further, a non-contact surface of "キクロン" sponge was also reciprocated 10 times in the same manner. 10g of the composition of example 4 or comparative example 4 was weighed into 50mL of a sample tube, and the hair tress subjected to the above treatment was added thereto and stirred for 3 minutes by a stirring rotor. Approximately 300mL of pure water was added to a 300mL tall beaker, and a tress of hair soaked in shampoo was added thereto and washed for 30 seconds. Further, the sample was rewashed in a separately prepared 300mL beaker with about 300mL of pure water added thereto. The wet tresses were placed on コ - ヅン wipers for 5 seconds. The non-contact surface of the コージン wiper was further mounted on the コ - ジン wiper for 5 seconds. The moisture retention rate was calculated according to the following formula. The results are shown in fig. 4.

[ number 1]

[ examples 5 to 8] moisture retention test of shampoo

The ingredients were weighed into a 300mL tall beaker according to Table 6. Heating to 70 deg.C to obtain uniform solution, stirring, and cooling until the liquid temperature reaches about 40 deg.C. Further, the moisture retention rate was determined by the same procedure as in example 4. The results are shown in fig. 4. Here, Pal-H represents palmitoylhistidine.

[ Table 6]

TABLE 6

Become intoIs divided into	Practice ofExample (b) 5	Practice ofExample (b) 6	Practice ofExample (b) 7	Practice ofExample (b) 8
					Purification ofWater (W)	44.75％	44.75％	44.75％	44.75％
CoconutOilAcyl glutaminesAcid(s) Na*8	7.30％	7.30％	7.30％	7.30％
					CoconutOilAcyl sweetAmmoniaAcid(s) K*9	2.40％	2.40％	2.40％	2.40％
CoconutOilAcyl cattleSulfonic acid Na*10	4.20％	4.20％	4.20％	4.20％
					CoconutOilAmides of carboxylic acidsC3Base ofSweet tasteVegetable dishAlkali*11	12.00％	12.00％	12.00％	12.00％
CoconutOilFat and oilFatAcid(s)IISecond stepAlcohol(s)Amides of carboxylic acids *12	4.00％	4.00％	4.00％	4.00％
					1，3-BG*13	4.00％	4.00％	4.00％	4.00％
LemonAcid(s) *14	0.35％	0.35％	0.35％	0.35％
					Poly(s) are polymerizedSeasonAmmonium salt-7*15	0.50％	0.50％	0.50％	0.50％
Benzene and its derivativesOxygen gasBase ofSecond stepAlcohol(s) *16	0.50％	0.50％	0.50％	0.50％
					Purification ofWater (W)	19.95％	19.95％	19.95％	19.95％
Pal-GH	0.05％
					IS-Ste-GH		0.05％
FO-GH			0.05％
					Pal-H				0.05％
Combination of Chinese herbsMeter	100.00％	100.00％	100.00％	100.00％

From the results shown in fig. 4, the shampoo containing the lipid peptide-based compound improved the moisture retention rate of hair as compared with the shampoo containing no lipid peptide-based compound (comparative example 4) (examples 4 to 8). Among them, when Pal-GH (examples 4 and 5), IS-Ste-GH (example 6) and FO-GH (example 7) were used as lipopeptide compounds, the moisture retention rate of hair was particularly improved and the moisture retention effect was excellent.

[ example 9 and comparative example 5]

Phases B and C were heat dissolved as per Table 7. Phase D was heated and treated with a homomixer (5000rpm, 3 minutes), and then the heated phases B and C were added, and further treated with a homomixer (5000rpm, 3 minutes). After the homomixer treatment, phase A was slowly added and further homomixer treatment (5000rpm, 3 minutes) was performed. Then, it was stirred and cooled until the liquid temperature became about 40 ℃.

[ Table 7]

TABLE 7

*17: manufactured by sunlight ケミカルズ Kabushiki Kaisha

*18: カルコール 6098 made of Kao (Kao) Kao

*19: manufactured by sunlight ケミカルズ Kabushiki Kaisha

*20: KF-96A-100CS manufactured by shin-Etsu chemical industry Co., Ltd

*21: KELCOGEL-CF-LA (manufactured by Zymuohua corporation)

*22: chemical preparation of (plant) pure

*23: (Zu) Tokyo chemical industry preparation

*24: (Zu) Tokyo chemical industry preparation

*25: (rafters アイ, テイー, オ are 1, 3-butanediol

*26: manufactured by Kabushiki Kaisha アイ & テイ & オー

*27: オレンジフラワー products made

*28: オレンジフラワ A product

The composition of example 9 or comparative example 5 (100. mu.L) was uniformly applied to an artificial leather cut to 2 cm. times.2 cm, dried at room temperature for 30 minutes, and the contact angle was evaluated using a contact angle meter Drop Master DMC-MCS (manufactured by Kyowa Kagaku Co., Ltd.). The results are shown in fig. 5.

From the results shown in fig. 5, the contact angle of the coating film obtained by the composition of the present invention was larger than that of the coating film obtained by the composition containing no lipid peptide-type compound (comparative example 5) (example 9).

The composition for forming a coating film of the present invention can form a coating film having good water repellency.

[ example 10 and comparative example 6] moisturizing test for Hair conditioner

Phase A was weighed according to Table 8 and heated to 75 ℃ to make a homogeneous solution. On the other hand, the components of phase B other than the ES-01 premix were warmed to 75 ℃ and the ES-01 premix warmed to 75 ℃ was added thereto. Then, phase B was added to phase A warmed to 75 ℃ and stirred to cool to around room temperature.

[ Table 8]

TABLE 8

*29: manufactured by sunlight ケミカルズ Kabushiki Kaisha

*30: manufactured by sunlight ケミカルズ Kabushiki Kaisha

*31: preparation of Huawang (plant)

*32: manufactured by advanced アルコ - ル industries (Ltd.)

*33: manufactured by sunlight ケミカルズ Kabushiki Kaisha

*34: manufactured by sunlight ケミカルズ Kabushiki Kaisha

*35: manufactured by sunlight ケミカルズ Kabushiki Kaisha

*36: manufactured by Riqing オイリオグループ ZU

*37: manufactured by shin-Etsu chemical industry

*38: manufactured by shin-Etsu chemical industry

*39: preparation of Limo ゼタミン Kabushiki Kaisha

*40: preparation of Bandan pharmaceutical industry

*41: manufactured by Tokyo chemical industry

*42: preparing from Chinese medicinal herbs

A bundle of human hair (black hair, 1g, 10cm) (manufactured by Fujikushisha corporation) was reciprocated 10 times by the "キクロン" sponge, and further, the non-contact surface of the "キクロン" sponge was also reciprocated 10 times in the same manner. 4.0g of the composition (conditioner) of example 10 or comparative example 6 was placed on the hair tresses thus treated, and after mixing by hand, the hair tresses were washed for 30 seconds by dipping and shaking the hair tresses in a 300mL beaker containing about 300mL of pure water. Further, the sample was rewashed in a separately prepared 300mL beaker with about 300mL of pure water added thereto. The wet tress was placed on コージン wipers for 5 seconds. The non-contact surface of the コージン wiper was further placed on the コージン wiper for 5 seconds. The moisture retention rate was calculated in accordance with the following equation. The results are shown in fig. 6.

The hair after the end of the test was observed by a Scanning Electron Microscope (SEM). The results are shown in fig. 7.

[ number 2]

As shown in fig. 6, the hair conditioner containing the lipid peptide-based compound had a higher moisture retention rate and a better moisture retention effect than the hair conditioner containing no lipid peptide-based compound (comparative example 6) (example 10).

Furthermore, from the SEM image shown in fig. 7, it was confirmed that the hair conditioner added with the lipid peptide type compound had a film formed on the hair. On the other hand, the hair conditioner to which the lipopeptide-type compound is not added does not form a film on hair.

[ formulation example 1] Oil-free skin cleansing preparation (Oil-free cleansing)

Oil-free skin cleansing compositions were prepared by mixing A, B, C and D according to the compositions shown in Table 9.

[ Table 9]

TABLE 9

[ formulation example 2] liquid Crystal cream

Liquid crystal creams were prepared by mixing A, B, C, D and E according to the compositions shown in Table 10.

[ Table 10]

Watch 10

[ formulation example 3] UV emulsion (O/W emulsion)

A, B, C and D were mixed in accordance with the composition shown in Table 11 to prepare UV emulsion (O/W emulsion).

[ Table 11]

TABLE 11

[ formulation example 4] O/W Foundation

A, B, C, D and E were mixed in accordance with the composition shown in Table 12 to prepare an O/W foundation.

[ Table 12]

TABLE 12

[ formulation example 5] No-silicon Hair conditioner (leave-on type)

According to the composition shown in Table 13, A, B, C and D were mixed to prepare a silicone-free hair rinse (leave-on type).

[ Table 13]

Watch 13

[ formulation example 6] shampoo

According to the composition shown in Table 14, A, B, C and D were mixed and mixed to prepare a shampoo.

[ Table 14]

TABLE 14

Example 11 and comparative example 7 evaluation of hair after conditioner treatment by finger-through

As example 11, a composition having the same composition as that of example 10 was prepared in accordance with Table 8. In comparative example 7, a composition having the same composition as that of comparative example 6 was prepared.

10g of the composition (hair conditioner) of example 11 or comparative example 7 was uniformly applied to the whole of a hair bundle (black hair, 1g, 10cm) (manufactured by Fujikusho), and after 5 minutes, the applied hair conditioner was washed. After standing at room temperature for 1 night, the frictional resistance was measured using a tactile TYPE33 (new eastern science, ltd.) and used as an index of the versatility.

The frictional resistance of example 11 and comparative example 7 is shown in fig. 8. As reference example 1, the frictional resistance of hair strands of human hair without conditioner treatment was also measured under the same conditions.

According to the results shown in fig. 8, the hair treated with the conditioner had a smaller frictional resistance than the hair not treated with the conditioner (example 11 and comparative example 7). Among them, the hair treated with the conditioner containing the lipopeptide-type compound had remarkably low frictional resistance and good manageability to the hair (example 11).

The composition for forming a coating film of the present invention can form a coating film having a small frictional resistance, that is, a coating film having excellent finger-passing properties and combing properties.

Example 12; preparation of O/W liquid Foundation

An O/W liquid foundation in which 17 mass% of the pigment was uniformly dispersed was prepared according to the following Table 15. In addition, the amounts of the respective ingredients in table 15 represent mass% (wt%) based on the total mass of the O/W liquid foundation.

In a 200mL beaker (manufactured by HARIO corporation), 34.0g of Fresh color base AQUA (Japanese: フレッシュカラーベース AQUA), 140.6g of purified water, 0.2g of sodium stearyl methyltaurate (NIKKOL SMT), 0.2g of LPA (lecithin), 0.2g of disodium ethylenediaminetetraacetate (EDTA-2Na), 0.4g of hydroxypropylcellulose, and 0.4g of xanthan gum (KELTROL CG-SFT) were mixed, and the mixture was stirred at 75 ℃ for 10 minutes (phase B). NIKKOL ニコムルス 414.0 g, NIKKOL NATURAL OIL 14.0g, and NIKKOL ニコガード 881.0 g were added to a 200mL beaker (manufactured by HARIO corporation), and the mixture was heated and stirred at 75 ℃ for 10 minutes (phase A). Phase A was added to phase B while stirring slowly, and the resulting mixture was emulsified at 75 ℃ for 3 minutes at 5000rpm using a homomixer (みづほ QUICK HOMO MIXER LR-1A, manufactured by Industrial Co., Ltd.). Further, 1.0g (phase D) of ES-01 premix heated to 75 ℃ was added thereto, and after heating and stirring at 75 ℃ for 2 minutes, it was cooled under stirring at room temperature until it became 40 ℃. After confirming that the temperature reached 40 ℃, NIKKOL NET-813-14.0 g (phase C) was added, and the mixture was cooled to 35 ℃ with stirring. In the above steps, the stirring was carried out at 200rpm in total.

Comparative example 8; preparation of O/W liquid Foundation

An O/W liquid foundation containing 17 mass% of a pigment uniformly blended was prepared as shown in Table 15 below.

In a 200mL beaker (manufactured by HARIO corporation), 34.0g of Fresh color base AQUA (Japanese: フレッシュカラーベース AQUA), 141.6g of purified water, 0.2g of sodium stearyl methyltaurate (NIKKOL SMT), 0.2g of LPA (lecithin), 0.2g of disodium ethylenediaminetetraacetate (EDTA-2Na), 0.4g of hydroxypropylcellulose, and 0.4g of xanthan gum (KELTROL CG-SFT) were mixed, and the mixture was stirred at 75 ℃ for 10 minutes (phase B). NIKKOL ニコムルス 414.0 g, NIKKOL NATURAL OIL 14.0g, and NIKKOL ニコガード 881.0 g were added to a 200mL beaker (manufactured by HARIO corporation), and the mixture was heated and stirred at 75 ℃ for 10 minutes (phase A). Phase A was added to phase B while stirring slowly, and the resulting mixture was emulsified at 75 ℃ for 3 minutes at 5000rpm using a homomixer (みづほ QUICK HOMO MIXER LR-1A, manufactured by Industrial Co., Ltd.). Then, stirring and cooling were carried out at room temperature until it became 40 ℃ and NIKKOL NET-813-14.0 g (phase C) was added, and stirring and cooling were carried out until it became 35 ℃. In the above steps, the stirring was carried out at 200rpm in total.

[ Table 15]

Watch 15

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 2: pure chemical plant

And (2) in color: manufactured by japan kazada corporation [ trade name: NISSO HPC SSL)

In addition, 4: manufactured by Zuozhu

Example 13 and comparative example 9 measurement of intensity of reflected light

The reflected light intensity was measured using the O/W liquid foundation of example 12 as example 13, and the reflected light intensity was measured using the O/W liquid foundation of comparative example 8 as comparative example 9.

The O/W liquid foundation of example 13 or the O/W liquid foundation of comparative example 9 was added to the bioskins (manufactured by Toho ビユーラツクス) so that the amount of the O/W liquid foundation was 10mg/cm²The coating was carried out in a thermostatic bath at 35 ℃. Using variable anglesThe photometer GP-5 (manufactured by color technology research, Inc. of Zukura) measured the intensity of reflected light at 45 ℃ when the incident light was at-45 ℃. The measurement results are shown in fig. 9.

From the results shown in fig. 9, strong reflected light was detected in the biological skin coated with the O/W liquid foundation of comparative example 9, whereas the reflected light was reduced by about 4 in the biological skin coated with the O/W liquid foundation containing the lipid peptide compound (example 13).

The composition for forming a coating film of the present invention can form a coating film capable of suppressing reflection of light.

Example 14 and comparative example 10 evaluation of cosmetic powders

The O/W liquid foundation of example 12 was used as the composition of example 14, and the O/W liquid foundation of comparative example 8 was used as the composition of comparative example 10.

0.5g of the O/W liquid foundation of example 14 or that of comparative example 10 was applied to human skin, and after the application was made uniformly, 0.5g of artificial sebum was added dropwise thereto, and the mixture was allowed to stand at room temperature for 30 minutes. Fig. 10 shows appearance photographs of example 14 and comparative example 10 after being left to stand at room temperature for 30 minutes.

According to the results shown in fig. 10, if artificial sebum is dropped on the o/W liquid powder of comparative example 10, the oil in the o/W liquid powder and the artificial sebum aggregate, and a cosmetic powder float is observed (comparative example 10). On the other hand, even when artificial sebum was dropped on an o/W liquid powder base containing a lipopeptide compound, no cosmetic powder was observed (example 14).

The composition for forming a coating film of the present invention can form a coating film which suppresses aggregation with sebum and is less likely to generate cosmetic powder.

EXAMPLE 15 AND COMPARATIVE EXAMPLE 11 preparation of malic acid-blended Hair conditioner

A foundation containing malic acid in an amount of 1.5 mass% (wt%) was prepared as shown in table 16 below.

Phase A was heated and stirred in a 200mL beaker (manufactured by HARIO Co., Ltd.) until 75 ℃. Combine phase B and phase C in a 200mL beaker and heat and stir until 75 ℃. Phase A was added to a mixture of phase B and phase C, and emulsification was carried out at 5000rpm for 5 minutes at 75 ℃ using a homomixer (QUICK HOMO MIXER LR-1A manufactured by みづほ industries, Ltd.). Then, phase D heated to 75 ℃ was added, and the mixture was stirred and heated at 75 ℃ for 5 minutes, and then cooled to 40 ℃ with stirring. In the above steps, the stirring was carried out at 200rpm in total.

[ Table 16]

TABLE 16

In addition, the method is as follows: manufactured by ルズ Corp. sunlight ケミ

In addition, 2: manufactured by advanced アルコ ー ル industries Ltd

And (2) in color: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 4: manufactured by advanced アルコ ー ル industries Ltd

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 6: preparation of Jingmo ビタミン E oil 700 from Jingmo ビタミン K

In addition, the color is 7: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, the color is 8: KF-96A-500CS, manufactured by shin-Etsu chemical industry Co., Ltd

In addition, the color is 9: pure chemical plant

In addition, the color is 10: fuji フイルム and Guanzizhu medicine (Yao)

The method is characterized in that: manufactured by JIAOYANG フ ァ イ ン ケミ カ ル ZU

The method is characterized by being in color in 12: manufactured by Tokyo chemical industry

The color is as follows: pure chemical plant

The color is 14: ナカライテスク manufactured by Kabushiki Kaisha

In addition, 15 is in color: pure chemical plant

The color is 16: manufactured by Wako pure chemical industries

EXAMPLE 16 AND COMPARATIVE EXAMPLE 12 moisturizing test for human Hair

(1) Preparation of damaged Hair sample (damaged Hair)

50 bundles (about 10cm per 1 bundle, about 1g) of human black hair (BS-B-A, manufactured by KAPPO ビューラックス Co., Ltd.) were applied with ギャツビー EX ハイブリーチ (a mixture of 18g powder, 70mL water, and 35g cream) in group 1 (manufactured by KAPPO マンダム Co., Ltd.), and left at room temperature for 1 hour to decolorize the hair. Then, the hair was washed with distilled water and dried for 30 minutes by using a constant temperature dryer (OF-300B, アズワン, manufactured by K.K.) set at 65 ℃. The above operation was repeated for a total of three times. Then, the hair was immersed in an aqueous solution 1L of 1 mass% sodium dodecyl sulfate (made by fuji フイルム and pure yaku) dissolved in distilled water, and washed with distilled water. ケイドライ (manufactured by Nippon paper クレシア) was used to remove excess water and then dried overnight at room temperature to prepare a damaged hair sample (bleached hair).

(2) Hair conditioner treatment

The prepared damaged hair sample was moistened with distilled water, and then excess water was removed by ケイドライ (manufactured by japanese paper クレシア corporation). Each 1g of the samples prepared in example 15 or comparative example 11 was applied to the hair by hand and left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of water, and excess water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and the mixture was dried overnight at room temperature.

(3) Moisture test of hair

The hair sample was cut to a length OF 1cm, 0.7g was weighed into a packaging container, and dried for 40 minutes by using a constant temperature dryer (OF-300B, manufactured by アズワン K.) set at 65 ℃. Then, the mass was measured again, and the mass reduction amount of the hair was defined as a water reduction amount, and the water loss rate from the hair was calculated from the following equation (table 17).

Moisture loss rate (%) - (1- (mass of hair after drying)/(mass of hair before drying)). 100

[ Table 17]

TABLE 17

		Water (W)Is divided intoLoss of powerRate of change (％)
			Reference toExample (b) 2	Is prepared fromTreatment ofBlack colourHair-like device	5.95
Reference toExample (b) 3	Float for anglingWhite colour (Bai)Hair-like device	6.17
			Ratio ofComparative example 12	By usingRatio ofComparative example11 ofSample (I)To carry outTo masterTreatment ofIs/are as followsBlack colourHair-like device	5.90
Practice ofExample (b) 16	By usingPractice ofExample (b)15 ofSample (I)To carry outTo masterTreatment ofIs/are as followsBlack colourHair-like device	5.69

According to the results shown in table 17, the black hair treated with the conditioner had a lower moisture loss rate than the black hair untreated with the conditioner (reference examples 2 and 3) (example 16 and comparative example 12). In particular, the hair conditioner containing the lipopeptide compound has a lower water loss rate of black hair and an improved moisturizing effect on human hair.

Example 17 and comparative example 13 evaluation test for restoration of luster of human Hair

On a microscope slide S1111 (manufactured by Songlanzi Kogyo Co., Ltd.), ナイスタック (registered trademark) NW-10 (manufactured by ニチバン Co., Ltd.) was pasted black picture paper PI-N86D (manufactured by マ ル アイ Co., Ltd.). On the hair sample, the hair samples after the moisturizing test were aligned in parallel without gaps, and pasted together with ナイスタック (registered trademark) NW-10(ニチバン (manufactured by KALI). The reflected light distribution was measured by a variable angle photometer GP-5 (manufactured by color technology research, Inc., Ltd.). The incident light was measured at-45 ℃ and the reflected light intensity at 45 ℃ was measured.

[ Table 18]

Watch 18

		At 45 deg. ofInverse directionShooting deviceLight (es)Strength of
			Reference toExample (b) 3	Is prepared fromTreatment ofBlack colourHair-like device	84.80
Reference toExample (b) 4	Float for anglingWhite colour (Bai)Hair-like device	40.36
			Ratio ofComparative example 13	Ratio ofComparative example12 ofHealth-care productAfter the wet testBlack colourHair-like device	46.38
Practice ofExample (b) 17	Practice ofExample (b)16 ofHealth-care productAfter the wet testBlack colourHair-like device	53.48

From the results shown in table 18, the black hair treated with the conditioner had a higher reflected light intensity and imparted luster to the hair (the luster was restored) than the black hair not treated with the conditioner (example 17 and comparative example 13). Among them, the reflected light intensity of the black hair treated with the hair conditioner containing the lipopeptide-type compound is particularly high, and the luster of the hair is further improved (the luster is further restored).

EXAMPLE 18 AND COMPARATIVE EXAMPLE 14 quantification of malic acid in Hair of human after Hair conditioner treatment

As example 18, the human hair treated with (2) of example 16 was used, and as comparative example 14, the human hair treated with (2) of comparative example 12 was used, and the quantitative amount of malic acid in the human hair was evaluated.

Malic acid was quantified by EnzyChrom manufactured by BioAssaysystems^TMA Malate Assay Kit (EMAL-100) was evaluated.

The human hair of example 18 or comparative example 14 was weighed in 200mg in a 50mL sample tube, and 4mL of purified water was added to conduct ultrasonication for 60 minutes to extract malic acid. To a 96-well plate, 20. mu.L of each extract, 74. mu. L, EnzymeA 1. mu. L, EnzymeB 1. mu.L of assay buffer, and 8. mu.L of NAD/MTT reagent were added. After 15 minutes, the absorbance (565nm) in the well prepared in the above procedure was measured by a plate reader (product of TECAN), and the absorbance of the sample itself was subtracted to calculate the net absorbance. The results of the test are shown in fig. 11.

According to the results shown in fig. 11, about 3 times as much malic acid was extracted from the human hair of example 18 as compared with comparative example 14.

The composition for forming a coating film of the present invention can form a coating film having a high retention of an active ingredient (a coating film capable of containing a large amount of an active ingredient).

Example 19, comparative example 15; SEM measurement of Hair treated with conditioner

As examples 19 and comparative examples 15, 1g of the hair conditioner prepared in examples 10 and 6 was applied to hair tresses (10cm, 50 tresses) of damaged hair prepared by the same procedure as in (1) of example 16, and left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of purified water, and the excess purified water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and dried overnight at room temperature. The surface observation of each hair was performed using a Scanning Electron Microscope (SEM) [ Miniscope (registered trademark) TM3000 (manufactured by hitachi ハイテクノロジーズ) ]. The results are shown in fig. 12. In example 19, the hair surface was observed to be smooth as compared with the bleached damaged hair and comparative example 15.

Example 20, comparative example 16; evaluation of moisture adsorption/desorption of Hair treated with conditioner

As example 20, a hair strand obtained by cutting 1 strand (about 10cm, about 1g) of damaged hair produced by the same procedure as in (1) of example 16 into 1cm and then treating the same as in (2) of example 16 was weighed out to obtain 16mg of hair, and the moisture adsorption/desorption amount was evaluated by using a moisture adsorption/desorption measuring apparatus IGAsorp (manufactured by ハ イ デ ン アイ ソ ケ ヤ マ). After the wet weight of each sample was measured at 25 ℃ and 40% humidity, the sample was dried at 25 ℃ and 0% humidity, and the drying was continued until the rate of change in the weight of the sample was less than 0.0001 mg/min. The relative humidity was increased from 0% to 90% in stages at intervals of 10%, and the water content in the hair was calculated from the equilibrium weight of the sample at each relative humidity point. Further, even when the relative humidity was decreased stepwise at intervals of 10% from 90% to 0%, the water content in the hair was calculated from the equilibrium weight of the sample at each relative humidity point. The above procedure was carried out by automatic measurement using a program, the weight of the sample was determined by an asymptotic method based on an LDF (linear impulse approximation) model for the purpose of calculating a weight value in a relaxed state of 99%, and the balance weight of the sample in the case where the LDF model was not applied was calculated by moving and averaging the measurement values measured for 180 minutes. The results of the obtained moisture ratios are shown in table 19 (when humidity was increased) and table 20 (when humidity was decreased). As comparative example 16, the results of treating human hair with (2) of comparative example 12 and the results of damaging hair are also shown in table 19. In comparative example 16, the adsorption of moisture was suppressed, and in example 19, the adsorption of moisture was more likely to be suppressed than in the case of damaged hair not treated with a conditioner.

[ Table 19]

Watch 19

[ Table 20]

Watch 20

Example 21 and comparative example 17; coefficient of kinetic Friction of Hair treated with conditioner ]

As example 21, the dynamic friction coefficient of the hair bundle surface of the damaged hair 1 bundle (about 10cm, about 1g) produced by the same procedure as in (1) of example 16 and treated in the same manner as in (2) of example 16 was measured and used as an index of guidance. The coefficient of dynamic friction was measured using a KES-SE Friction-sensitive tester (manufactured by カトーテック K.) and a 10mm square silicon sensor was used as the sensor. The hair tress subjected to the same treatment as in (2) of comparative example 12 was also measured and set as comparative example 17. The results of both are shown in fig. 13. The hair produced in example 21 had a tendency to have a lower coefficient of dynamic friction on the hair surface than that of comparative example 17.

Example 22 and comparative example 18; preparation of succinic acid blended Hair conditioner

A hair conditioner containing 1.5 mass% of succinic acid was prepared according to table 21 below. Phase A was heated and stirred in a 200mL beaker (manufactured by HARIO Co., Ltd.) until 75 ℃. Combine phase B and phase C in a 200mL beaker and heat and stir until 75 ℃. Phase A was added to phase B + C, and emulsified at 75 ℃ for 5 minutes at 5,000rpm using a homomixer (QUICK HOMO MIXER LR-1A みづほ, manufactured by Kokai Co., Ltd.). Then, phase D heated to 75 ℃ was added, and the mixture was stirred and heated at 75 ℃ for 5 minutes, and then cooled to 40 ℃ with stirring. In the above steps, the stirring was carried out at 200rpm in total.

[ Table 21]

TABLE 21

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 2: manufactured by advanced アルコ ー ル industries Ltd

And (2) in color: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 4: manufactured by advanced アルコ ー ル industries Ltd

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 6: preparation of Jingmo ビタミン E oil 700 from Jingmo ビタミン K

In addition, the color is 7: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, the color is 8: KF-96A-500CS, manufactured by shin-Etsu chemical industry Co., Ltd

In addition, the color is 9: pure chemical plant

In addition, the color is 10: fuji フイルム and Guanzizhu medicine (Yao)

The method is characterized in that: manufactured by JIAOYANG フ アイ ン ケミ カ ル ZU

The method is characterized by being in color in 12: manufactured by Tokyo chemical industry

The color is as follows: pure chemical plant

The color is 14: ナカライテスク manufactured by Kabushiki Kaisha

In addition, 15 is in color: pure chemical plant

The color is 16: manufactured by Wako pure chemical industries

Example 23 and comparative example 19; evaluation of succinic acid amount in Hair treated with conditioner

In example 23 and comparative example 19, 1g of each of the conditioners prepared in example 22 and comparative example 18 was applied to the hands, and 1 bundle (about 10cm, about 1g) of damaged hair prepared by the same procedure as in (1) of example 16 was left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of water, and excess water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and the mixture was dried overnight at room temperature. 3 samples were prepared by performing the above-described treatment 1 time, 2 times, and 3 times. The prepared damaged hair samples were cut to a length of 1 cm. The amount of succinic acid was evaluated using a succinic acid colorimetric Assay Kit (manufactured by Megazyme). The human hairs treated in example 23 and comparative example 19 were weighed into sample tubes of 200mg to 50mL, respectively, and purified water of 4mL was added thereto and sonicated for 60 minutes to extract succinic acid. To a 96-well plate, 10. mu.L of each extract and 210. mu. L, Buffer 20. mu. L, NADH 20 purified water, 20. mu. L, ATP/PEP/CoA, 20. mu. L, PK/L-LDH, 2. mu.L of SCS were added, and the mixture was allowed to stand for 3 minutes and then 2. mu.L of SCS was added. Absorbance (340nm) in the wells prepared in the above procedure was measured by a microplate reader (manufactured by TECAN Co., Ltd.), and absorbance of the sample itself was subtracted to calculate net absorbance. The results of the test are shown in fig. 14. Depending on the number of days of treatment, the extraction amount of succinic acid from hair was increased, and about 2 times as much succinic acid was extracted from the human hair of example 23 as compared with comparative example 19.

Example 24, comparative example 20; evaluation of permeation amount of succinic acid and lipid peptide in human Hair ]

In examples 24 and 20, 1g of each of the conditioners prepared in examples 22 and 18 was applied to the hands, and 1 bundle (about 10cm, about 1g) of damaged hair prepared by the same procedure as in (1) of example 16 was left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of water, and excess water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and the mixture was dried overnight at room temperature. The above treatment was repeated for 3 days, and the lipid peptides contained in the succinic acid and ES-01 premix were analyzed using a time-of-flight secondary ion mass spectrometer tof.sims5 (manufactured by hitachi ハイテクサイエンス, ltd.). Each hair sample was sampled near the center of the hair, and a cross section was produced. Bi is selected as the primary ion source. The resulting hair section is shown in fig. 15. A higher succinic acid strength was confirmed from the hair section of example 24 compared to comparative example 20. Furthermore, example 24 confirmed that the lipopeptide in the ES-01 premix was localized on the hair surface.

Example 25 and comparative example 21; zeta-potential measurement of Hair surface treated with conditioner

As examples 25 and comparative examples 21, 1g of each of the conditioners prepared in examples 22 and 18 was applied to the hands, and 1 bundle (about 10cm, about 1g) of damaged hair prepared by the same procedure as in (1) of example 16 was left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of water, and excess water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and the mixture was dried overnight at room temperature. The surface zeta potential of the hair sample was evaluated by a solid surface zeta potential apparatus SurPASS (manufactured by Anton-Paar). The electrolyte was adjusted to 1mM KCl and measured at 23 ℃. The results are shown in Table 22. In comparative example 21, the surface potential is closer to the cationic property than the bleached damaged hair, and it is confirmed in example 25 that the surface potential is further cationic.

[ Table 22]

	(mV)
		Damaged hairHair-like device	-5.8±0.458
Ratio ofComparative example 21	-1.547±0.35
		Practice ofExample (b) 25	2.013±0.25

Example 26 and comparative example 22; evaluation of hardness of Hair surface treated with conditioner

In example 26 and comparative example 22, 1g of each of the conditioners prepared in example 22 and comparative example 18 was applied to the hands, and 1 bundle (about 10cm, about 1g) of damaged hair prepared by the same procedure as in (1) of example 16 was left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of water, and excess water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and the mixture was dried overnight at room temperature. The hardness of the surface of each of the above hair samples was measured by ハイジトロン TI980 トライボインデンター (manufactured by Bruker). The depth of penetration was set to 1 μm, and the average value of 10 measurements was calculated using a triangular pyramid (Japanese: バーコビッチ) type indenter. The results are shown in fig. 16. It was shown that the surface of the damaged hair subjected to the bleaching treatment was hardened compared with the untreated black hair. It was shown that the hair of comparative example 22 was soft on the surface and the hair of example 26 was further soft on the surface, as compared with the damaged hair.

Example 27 and comparative example 23; evaluation of moisture adsorption/desorption of Hair treated with conditioner

In examples 27 and 23, 1g of each of the conditioners prepared in examples 22 and 18 was applied to the hands, and 1 bundle (about 10cm, about 1g) of damaged hair prepared by the same procedure as in (1) of example 16 was left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of water, and excess water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and the mixture was dried overnight at room temperature. The prepared treated sample was cut to 1cm, weighed 3mg, and the amount of moisture adsorption and desorption of the obtained human hair was evaluated using a moisture adsorption and desorption measuring apparatus IGAsorp (manufactured by ハ イ デ ン アイ ソ ケ ヤ マ). The hair was dried at a relative humidity of 0% for 2 days, and the amount of change in mass was measured until the humidity was raised at once to 90% relative humidity. The above steps are performed by automatic measurement using a program. The results are shown in fig. 17. Comparative example 23 suppressed the adsorption of moisture, and example 27 tended to suppress further the adsorption of moisture, compared with the damaged hair without conditioner treatment.

Example 28, comparative example 24; change of gloss with time due to sebum floating ]

The change in gloss with time due to sebum floating was evaluated by using the O/W liquid foundation of example 12 as example 28 and the O/W liquid foundation of comparative example 8 as comparative example 24. The O/W liquid foundations of example 12 and comparative example 8 were applied to the face of the subject, and the life was performed as usual, and the surface gloss of the face was measured using a gloss meter GL200 (manufactured by Courage + khazaka electronics) every 1 hour after 1 hour of application of each foundation until 6 hours after application of each foundation. The results are shown in fig. 18. In example 28, gloss due to sebum lifting with time was also suppressed after 6 hours, as compared with comparative example 24.

Example 29 and comparative example 25; preparation of cosmetic liquid

A cosmetic liquid containing 0.005% hyaluronic acid was prepared according to table 23 below. Phase A was heated and stirred in a 200mL beaker (manufactured by HARIO Co., Ltd.) until 75 ℃. Combine phase B, phase C, and phase D in a 200mL beaker and heat and stir until 75 ℃. To the B + C + D phases, phase A was added and stirred at 75 ℃ for 5 minutes. Then, the mixture was stirred and cooled until it became 45 ℃ and phase E was added thereto and stirred and cooled until it became 35 ℃. In the above steps, the stirring was carried out at 200rpm in total.

[ Table 23]

TABLE 23

In addition, the method is as follows: preparation of Bandan pharmaceutical industry

In addition, 2: ダイセル chemical industry Co., Ltd

And (2) in color: wanshan medicine industry (Kabushi)

In addition, 4: preparation of Huawang (plant)

In addition, the method is as follows: KELTROL CG-SFT manufactured by Trifolium oryzae

In addition, 6: キ ツ コ ー マ ン バイオ ケミ フ ア manufactured by Kabushiki Kaisha

Example 30 and comparative example 26; moisturizing effect of cosmetic liquid

The moisturizing effect was evaluated by using the cosmetic liquid of example 29 as example 30 and the cosmetic liquid of comparative example 25 as comparative example 26. The cosmetic liquids of example 29 and comparative example 25 were applied to the inner side of the forearm of the subject, and the amount of keratinous water in the forearm was measured at 1 hour intervals from 1 hour after application of the cosmetic liquid in an environment of 50% humidity and 24 ℃ until 7 hours after application of the cosmetic liquid using a Corneometer CM825 (manufactured by Courage + khazaka electronics). The coated forearm portion was optionally extracted at 10 points and measured, and the average value thereof was set as the measurement result. The results are shown in fig. 19. In example 30, even after 7 hours, the moisture content in the keratin was high as compared with comparative example 26, and it was confirmed that the moisture-retaining effect was exhibited.

Example 31, example 32, comparative example 27; preparation of Hair conditioner containing Keratin

A hair conditioner containing 1.5 mass% keratin was prepared according to table 24 below. Phase A was heated and stirred in a 200mL beaker (manufactured by HARIO Co., Ltd.) until 75 ℃. Combine phase B and phase C in a 200mL beaker and heat and stir until 75 ℃. Phase A was added to phase B + C, and emulsified at 75 ℃ for 5 minutes at 5000rpm using a homomixer (QUICK HOMO MIXER LR-1A みづほ, manufactured by Kokai Co., Ltd.). Then, phase D heated to 75 ℃ was added, and the mixture was stirred and heated at 75 ℃ for 5 minutes, and then cooled to 40 ℃ with stirring. In the above steps, the stirring was carried out at 200rpm in total.

[ Table 24]

Watch 24

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 2: manufactured by advanced アルコ - ル industries (Ltd.)

And (2) in color: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 4: manufactured by advanced アルコ ー ル industries Ltd

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 6: preparation of Jingmo ビタミン E oil 700 from Jingmo ビタミン K

In addition, the color is 7: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, the color is 8: KF-96A-500CS, manufactured by shin-Etsu chemical industry Co., Ltd

In addition, the color is 9: pure chemical plant

In addition, the color is 10: fuji フイルム and Yaoyaku (Yaozi) preparation

The method is characterized in that: manufactured by JIAOYANG フ アイ ン ケミ カ ル ZU

The method is characterized by being in color in 12: manufactured by Tokyo chemical industry

The color is as follows: カツミヤコー BU (Bo-jin) made by Yiwan ファルコス Kabushiki Kaisha

The color is 14: ナカライテスク manufactured by Kabushiki Kaisha

In addition, 15 is in color: pure chemical plant

The color is 16: manufactured by Wako pure chemical industries

Example 33, example 34, comparative example 28; evaluation of Keratin amount of Hair treated with conditioner

As examples 33, 34 and 28, 1g of each of the conditioners prepared in examples 31, 32 and 27 was applied to a hand, and 1 bundle (about 10cm, about 1g) of damaged hair prepared by the same procedure as in (1) of example 16 was left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of methanol (manufactured by pure chemical corporation), and excess methanol was removed by ケイドライ (manufactured by japanese paper クレシア corporation), and the mixture was dried overnight at room temperature. The prepared damaged hair samples were cut to a length of 1 cm. The amount of Keratin was evaluated using a Keratin Orange α -Keratin detection Kit (Keratin Orange α -Keratin Assay Kit, manufactured by biocolor). Human hair treated in examples and comparative examples5mg of each reagent was weighed into a 1.5mL microtube (manufactured by Eppendorf Co., Ltd.), 1mL of each Digestion reagent (diagnostic reagent) was added thereto, and the mixture was mixed by vortexing for 1 hour. A reference standard (. alpha. -keratin 5.0mg/mL) was diluted with the digestion reagent to prepare standard curve samples (0, 1,2, 3,4, 5 mg/mL). To 200. mu.L of each of the hair sample and the standard curve sample, 200. mu.L of each of neutralizing solutions (1M HCl) was added, and the pH of each solution was neutralized. To the sample, 50. mu.L each of the dye reagents was added, mixed by vortexing, and then allowed to stand for 30 minutes to react. To salt out the keratin extracted from each hair sample, a saturated solution ((NH) was added to the sample₄)₂SO₄) Each 450. mu.L. To remove unbound Orange G, the sample was centrifuged at 12,000rpm for 10 minutes, the supernatant was discarded, 50 μ L each of digestion reagents was added, and the keratin was solubilized by vortexing to mix well. Each 200. mu.L of each prepared sample was transferred to a 96-well plate, and the absorbance (480nm) was measured by a microplate reader (manufactured by TECAN Co., Ltd.), and the absorbance of the sample itself was subtracted to calculate the net absorbance. The results of the test are shown in fig. 20. Compared to comparative example 28, a high amount of keratin was extracted from the hair of example 33 and example 34.

Example 35 and comparative example 29; preparation of Hair conditioner containing 18-MEA

Hair conditioners containing 1.5% by mass of 18-methyleicosanoic acid (18-MEA) were prepared according to the following Table 25. Phase A was heated and stirred in a 200mL beaker (manufactured by HARIO Co., Ltd.) until 75 ℃. Combine phase B and phase C in a 200mL beaker and heat and stir until 75 ℃. Phase A was added to phase B + C, and emulsified at 75 ℃ for 5 minutes at 5000rpm using a homomixer (QUICK HOMO MIXER LR-1A みづほ, manufactured by Kokai Co., Ltd.). Then, phase D heated to 75 ℃ was added, and the mixture was stirred and heated at 75 ℃ for 5 minutes, and then cooled to 40 ℃ with stirring. In the above steps, the stirring was carried out at 200rpm in total.

[ Table 25]

TABLE 25

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 2: manufactured by advanced アルコ - ル industries (Ltd.)

And (2) in color: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 4: manufactured by advanced アルコ - ル industries (Ltd.)

In addition, the method is as follows: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, 6: preparation of Jingmo ビタミン E oil 700 from Jingmo ビタミン K

In addition, the color is 7: manufactured by sunlight ケミカルズ Kabushiki Kaisha

In addition, the color is 8: KF-96A-500CS, manufactured by shin-Etsu chemical industry Co., Ltd

In addition, the color is 9: pure chemical plant

In addition, the color is 10: fuji フイルム and Guanzizhu medicine (Yao)

The method is characterized in that: manufactured by JIAOYANG フ ァ イ ン ケミ カ ル ZU

The method is characterized by being in color in 12: manufactured by Tokyo chemical industry

The color is as follows: クロ -Cutisssential 18-MEA40 manufactured by ダジヤパン

The color is 14: ナカライテスク manufactured by Kabushiki Kaisha

In addition, 15 is in color: pure chemical plant

The color is 16: manufactured by Wako pure chemical industries

Example 36 and comparative example 30; SEM measurement of Hair treated with conditioner

In examples 36 and comparative examples 30, 1g of each of the conditioners prepared in examples 35 and 29 was applied to the hands, and 1 bundle (about 10cm, about 1g) of damaged hair prepared by the same procedure as in (1) of example 16 was left to stand for 5 minutes. Then, the mixture was washed by shaking in a 300mL beaker containing 300mL of purified water, and the excess purified water was removed by ケイドライ (manufactured by japanese patent No. クレシア), and dried overnight at room temperature. This operation was repeated 10 times, and then the surface of each of the produced hairs was observed using a schottky field emission type scanning electron microscope JSM-7800F (manufactured by japan electronics corporation). The fixation of the sample was measured using a carbon tape under the condition of an acceleration voltage of 0.7 kV. Fig. 21 shows the measurement results of damaged hair. While hair damage and the structure of the surface of the cuticle (cuticle) were observed in comparative example 30, example 36 confirmed that the cuticle surface was covered with a membrane.