阅读说明：本技术 一种消渴降糖薄膜衣片及其制备方法 (A film-coated tablet for quenching thirst and lowering blood sugar, and its preparation method ) 是由 杨飞 廖丽军 陈红辉 于 2020-11-13 设计创作，主要内容包括：本发明涉及消渴降糖制备技术领域,尤其涉及一种消渴降糖薄膜衣片,包括如下重量份的组分制成：番石榴叶70份、玉米淀粉10份、清膏5份、2%颗粒量的滑石粉2份、0.5%的硬脂酸镁6份、5%～10%的羟丙基甲基纤维素2份、60%～70%乙醇3份、0.8%～1.2%甘油1份以及1.2%～2.0%的红氧化铁1份。本发明中通过将番石榴叶风干水提后,将番石榴叶中的叶含有的β-谷甾醇、三萜类、槲皮素等成分进行提取具有燥湿健脾；清热解毒,适合需要清热解毒的人群,同时番石榴叶具有很强的降血糖作用,能够降糖消渴,滋阴润肺,调和脾胃,补肾强身,主要针对糖尿病患者和调整高血糖人群,给人们带来方便,其次原料丰富,容易获取,成本较低。(The invention relates to the technical field of preparation of diabetes and blood sugar reduction, in particular to a diabetes and blood sugar reduction film-coated tablet which is prepared from the following components in parts by weight: 70 parts of guava leaves, 10 parts of corn starch, 5 parts of clear paste, 2 parts of 2 percent of talcum powder with particle amount, 6 parts of 0.5 percent of magnesium stearate, 2 parts of 5 to 10 percent of hydroxypropyl methyl cellulose, 3 parts of 60 to 70 percent of ethanol, 1 part of 0.8 to 1.2 percent of glycerin and 1 part of 1.2 to 2.0 percent of red ferric oxide. According to the invention, after the guava leaves are dried in the air and extracted with water, the components of beta-sitosterol, triterpenes, quercetin and the like contained in the leaves of the guava leaves are extracted to dry the dampness and strengthen the spleen; the guava leaf tea has the advantages of clearing heat and removing toxicity, being suitable for people needing to clear heat and remove toxicity, having a very strong blood sugar reducing effect, reducing blood sugar and quenching thirst, nourishing yin and moisturizing lung, harmonizing spleen and stomach, tonifying kidney and strengthening body, bringing convenience to people mainly aiming at diabetes patients and people adjusting hyperglycemia, along with abundant raw materials, easiness in obtaining and low cost.)

1. A thirst quenching and sugar reducing film coated tablet is characterized by comprising the following raw materials in parts by weight: 70-80 parts of guava leaves, 10-12 parts of corn starch, 5-8 parts of clear paste, 2-3 parts of 2% of talcum powder, 6-8 parts of 0.5% magnesium stearate, 2-4 parts of 5-10% hydroxypropyl methyl cellulose, 3-5 parts of 60-70% ethanol, 1-2 parts of 0.8-1.2% glycerol and 1-2 parts of 1.2-2.0% red ferric oxide.

2. The coated tablet of claim 1, wherein the amount of corn starch is the theoretical yield minus the weight of the extract multiplied by the solids content of the extract.

3. A method for preparing a thirst quenching and sugar reducing film-coated tablet, which comprises the method for preparing the thirst quenching and sugar reducing film-coated tablet as claimed in any one of claims 1 or 2, and is characterized by comprising the following steps:

s1, cleaning, namely cleaning the guava leaves in proper weight parts, and controlling water for 20-30 minutes;

s2, air-drying, namely, putting the guava leaves in the step 1 into an air dryer to air-dry for 24 hours at a low temperature;

s3, crushing, namely putting the guava leaves air-dried in the step 2 into a crusher for crushing;

s4, water extraction, namely pouring the guava leaf powder obtained in the step 3 into a marmite, adding clear water to immerse the medicinal materials, soaking for a proper time, heating to boil, keeping slightly boiling for a certain time, separating and decocting medicinal liquid, decocting medicinal residues for 2 times according to a method until the decoction is light in flavor, combining the decocted liquid for each time, and stirring;

s5, carrying out alcohol precipitation, namely cooling the liquid medicine in the step 4 to room temperature, adding the liquid medicine into an alcohol precipitation tank, adding an appropriate amount of 60-70% ethanol, stirring, transferring the mixture into a cold storage, standing the mixture at 5-10 ℃ for 24-48 h, and extracting supernatant;

s6, concentrating, namely adding a proper amount of corn starch into the liquid medicine obtained in the step 5, fully stirring, adding into a low-temperature vacuum concentration tank, and concentrating into thick paste;

s7, granulating, namely putting the thick paste obtained in the step 6 into a dryer, adding a prescribed amount of corn starch, putting the mixture into a hopper of a boiling granulation dryer, preheating for 5-15 minutes, spraying clear paste, granulating, continuously drying the granules for 20-30 minutes after the clear paste is sprayed, controlling the water content within 6%, taking the granules out of a pot, sampling, and carrying out granule intermediate inspection;

s8, finishing and sieving: pulverizing the prepared granules with a pulverizer with a screen with the aperture of 0.8mm, and grading;

s9, adding a proper amount of 2% talcum powder and a proper amount of 0.5% magnesium stearate into the qualified granules, and mixing in a two-dimensional motion mixer for 30 +/-5 minutes;

s10, tabletting, namely putting the Chinese medicinal balls obtained in the step 9 into a tabletting machine for tabletting, tabletting according to the weight of the base sheet of 0.27 g/tablet, and controlling the weight difference within +/-6.5%;

s11, preparing a coating solution, selecting hydroxypropyl methyl cellulose as a film coating material, adding a proper amount of 60-70% ethanol to make the concentration of the coating material reach 3-4%, stirring to dissolve the coating material, filtering, adding 0.8-1.2% of glycerol and 1.2-2.0% of red ferric oxide into filtrate, stirring uniformly, grinding colloid, and sieving with a 100-mesh sieve to prepare the coating solution for later use;

s12, coating, namely adding the tablet in the step 11 into a coating pan, heating to 45-55 ℃, starting the rotation speed of the coating pan to be 13r/min, controlling the air pressure to be 4-6 Pa, controlling the speed of liquid spraying to ensure that the coating liquid is sprayed on the surface of the tablet and is dried in time, reducing the rotation speed of the coating pan after the coating liquid is sprayed until the color of the surface of the tablet is uniform, stopping heating and cooling to room temperature, and taking out the tablet;

and S13, adding the tablets in the step 12 into a tablet packaging machine for packaging.

4. The method for preparing a thirst quenching and blood sugar reducing film coated tablet according to claim 3, wherein the air drying temperature in S2 is 60-80 ℃.

5. The method for preparing a thirst quenching and blood sugar reducing film coated tablet according to claim 3, wherein the drying temperature of the material in S7 is 50-85 ℃.

6. The method for preparing a thirst quenching and blood sugar reducing film coated tablet according to claim 3, wherein the rotation speed of a coating pan in S12 is controlled at 13-15 r/min.

7. The method for preparing a thirst quenching and blood sugar reducing film coated tablet according to claim 3, wherein the degree of vacuum in S6 is 0.003 MPa, and the concentration temperature is 40-50 ℃.

Technical Field

The invention relates to the technical field of preparation of diabetes and blood sugar reduction, in particular to a diabetes and blood sugar reduction film-coated tablet and a preparation method thereof.

Background

By 2017, the number of diabetic patients in China is over 1 hundred million, and the number of "before sugar", namely the pre-diabetic population is conservative estimated to be 5 hundred million. "Pre-glycation" is a state between diabetes and euglycemia and is considered to be the integral stage of diabetes.

The existing hypoglycemic drugs are taken for a long time to reduce the liver and kidney functions of patients, and simultaneously, the patients may have skin itch and rash lamp symptoms when taking the hypoglycemic drugs, so that the requirements of the patients for long-term taking are difficult to meet.

Disclosure of Invention

The invention aims to solve the defects in the prior art and provides a thirst quenching and blood sugar reducing film-coated tablet and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a thirst quenching and sugar reducing film coated tablet comprises the following components in parts by weight: 70-80 parts of guava leaves, 10-12 parts of corn starch, 5-8 parts of clear paste, 2-3 parts of 2% of talcum powder, 6-8 parts of 0.5% magnesium stearate, 2-4 parts of 5-10% hydroxypropyl methyl cellulose, 3-5 parts of 60-70% ethanol, 1-2 parts of 0.8-1.2% glycerol and 1-2 parts of 1.2-2.0% red ferric oxide.

Preferably, the corn starch content is the theoretical yield minus the extract weight multiplied by the extract solids content.

In addition, in order to solve the problems, the invention also provides a preparation method of the thirst quenching and blood sugar reducing film-coated tablet, which comprises the following steps:

s1, cleaning, namely cleaning the guava leaves in proper weight parts, and controlling water for 20-30 minutes;

s2, air-drying, namely, putting the guava leaves in the step 1 into an air dryer to air-dry for 24 hours at a low temperature;

s3, crushing, namely putting the guava leaves air-dried in the step 2 into a crusher for crushing;

s4, water extraction, namely pouring the guava leaf powder obtained in the step 3 into a marmite, adding clear water to immerse the medicinal materials, soaking for a proper time, heating to boil, keeping slightly boiling for a certain time, separating and decocting medicinal liquid, decocting medicinal residues for 2 times according to a method until the decoction is light in flavor, combining the decocted liquid for each time, and stirring;

s5, carrying out alcohol precipitation, namely cooling the liquid medicine in the step 4 to room temperature, adding the liquid medicine into an alcohol precipitation tank, adding an appropriate amount of 60-70% ethanol, stirring, transferring the mixture into a cold storage, standing the mixture at 5-10 ℃ for 24-48 h, and extracting supernatant;

s6, concentrating, namely adding a proper amount of corn starch into the liquid medicine obtained in the step 5, fully stirring, adding into a low-temperature vacuum concentration tank, and concentrating into thick paste;

s7, granulating, namely putting the thick paste obtained in the step 6 into a dryer, adding a formula amount of corn starch, putting the mixture into a hopper of a boiling granulation dryer, and preheating for 5-15 minutes; spraying clear paste, granulating, continuously drying the granules for 20-30 minutes after the clear paste is sprayed, controlling the water content within 6%, taking out of the pot, sampling, and carrying out granule intermediate inspection;

s8, finishing and sieving: pulverizing the prepared granules with a pulverizer with a screen with the aperture of 0.8mm, and grading;

s9, adding a proper amount of 2% talcum powder and a proper amount of 0.5% magnesium stearate into the qualified granules, and mixing in a two-dimensional motion mixer for 30 +/-5 minutes;

s10, tabletting, namely putting the Chinese medicinal balls obtained in the step 9 into a tabletting machine for tabletting, tabletting according to the weight of the base sheet of 0.27 g/tablet, and controlling the weight difference within +/-6.5%;

s11, preparing a coating solution, selecting hydroxypropyl methyl cellulose as a film coating material, adding a proper amount of 60-70% ethanol to make the concentration of the coating material reach 3-4%, stirring to dissolve the coating material, filtering, adding 0.8-1.2% of glycerol and 1.2-2.0% of red ferric oxide into filtrate, stirring uniformly, grinding colloid, and sieving with a 100-mesh sieve to prepare the coating solution for later use;

s12, coating, namely adding the tablet obtained in the step 11 into a coating pan, heating to 45-55 ℃, wherein the rotating speed of the coating pan is 13r/min, the rotating speed of the coating pan can be properly increased along with the coating, the air pressure is controlled to be 4-6 Pa, the speed of spraying liquid is controlled, so that the coating liquid is sprayed on the surfaces of the tablets and is dried in time, the rotating speed of the coating pan can be reduced after the coating liquid is sprayed until the colors of the surfaces of the tablets are uniform, and the tablets are taken out after heating and cooling to room temperature;

and S13, adding the tablets in the step 12 into a tablet packaging machine for packaging.

Preferably, the air drying temperature in the S2 is 60-80 ℃.

Preferably, the drying temperature of the material in the S7 is 50-85 ℃.

Preferably, the rotating speed of the coating pan in S12 is controlled to be 13-15 r/min.

Preferably, the vacuum degree in the S6 is 0.003 MPa, and the concentration temperature is 40-50 ℃.

Compared with the prior art, the invention has the beneficial effects that:

according to the invention, after the guava leaves are dried in the air and extracted with water, the components of beta-sitosterol, triterpenes, quercetin and the like contained in the leaves of the guava leaves are extracted to dry the dampness and strengthen the spleen; the guava leaf tea has the advantages of clearing heat and removing toxicity, being suitable for people needing to clear heat and remove toxicity, having a very strong blood sugar reducing effect, reducing blood sugar and quenching thirst, nourishing yin and moisturizing lung, harmonizing spleen and stomach, tonifying kidney and strengthening body, bringing convenience to people mainly aiming at diabetes patients and people adjusting hyperglycemia, along with abundant raw materials, easiness in obtaining and low cost.

Drawings

FIG. 1 is a process flow diagram of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Example 1

A thirst quenching and sugar reducing film coated tablet comprises the following components in parts by weight: 70 parts of guava leaves, 10 parts of corn starch, 5 parts of clear paste, 2 parts of 2% of talcum powder with particle amount, 6 parts of 0.5% magnesium stearate, 2 parts of 5-10% hydroxypropyl methyl cellulose, 3-5 parts of 60-70% ethanol, 1 part of 0.8-1.2% glycerol and 1 part of 1.2-2.0% red ferric oxide.

The corn starch content is the theoretical yield minus the extract weight multiplied by the extract solids content.

In addition, in order to solve the problems, the invention also provides a preparation method of the thirst quenching and blood sugar reducing film-coated tablet, which comprises the following steps:

s1, cleaning, namely cleaning the guava leaves in proper weight parts, and controlling water for 20 minutes;

s2, air-drying, namely, putting the guava leaves in the step 1 into an air dryer to air-dry for 24 hours at a low temperature;

s3, crushing, namely putting the guava leaves air-dried in the step 2 into a crusher for crushing;

s4, water extraction, namely pouring the guava leaf powder obtained in the step 3 into a marmite, adding clear water to immerse the medicinal materials, soaking for a proper time, heating to boil, keeping slightly boiling for a certain time, separating and decocting medicinal liquid, decocting medicinal residues for 2 times according to a method until the decoction is light in flavor, combining the decocted liquid for each time, and stirring;

s5, carrying out alcohol precipitation, namely cooling the liquid medicine in the step 4 to room temperature, adding the liquid medicine into an alcohol precipitation tank, adding an appropriate amount of 60-70% ethanol, stirring, transferring the mixture into a cold storage, standing the mixture at 5 ℃ for 24 hours, and extracting supernatant;

s6, concentrating, namely adding a proper amount of corn starch into the liquid medicine obtained in the step 5, fully stirring, adding into a low-temperature vacuum concentration tank, and concentrating into thick paste;

s7, granulating, namely putting the thick paste obtained in the step 6 into a dryer, adding the corn starch with the prescription amount, putting the mixture into a hopper of a boiling granulation dryer, and preheating for 5 minutes; spraying the clear paste, granulating, continuously drying the granules for 20 minutes after the clear paste is sprayed, controlling the water content within 6 percent, taking out of the pot, sampling, and carrying out granule intermediate inspection;

s8, finishing and sieving: pulverizing the prepared granules with a pulverizer with a screen with the aperture of 0.8mm, and grading;

s9, adding a proper amount of 2% talcum powder and a proper amount of 0.5% magnesium stearate into the qualified granules, and mixing in a two-dimensional motion mixer for 30 minutes;

s10, tabletting, namely putting the Chinese medicinal balls obtained in the step 9 into a tabletting machine for tabletting, tabletting according to the weight of the base sheet of 0.27 g/tablet, and controlling the weight difference within +/-6.5%;

s11, preparing a coating solution, selecting hydroxypropyl methyl cellulose as a film coating material, adding a proper amount of 60-70% ethanol to make the concentration of the coating material reach 3-4%, stirring to dissolve the coating material, filtering, adding 0.8-1.2% of glycerol and 1.2-2.0% of red ferric oxide into filtrate, stirring uniformly, grinding colloid, and sieving with a 100-mesh sieve to prepare the coating solution for later use;

s12, coating, namely adding the tablet in the step 11 into a coating pan, heating to 45 ℃, wherein the rotating speed of the coating pan is 13r/min, the rotating speed of the coating pan can be properly increased along with the coating, the air pressure is controlled to be 4Pa, the speed of spraying liquid is controlled, so that the coating liquid is sprayed on the surface of the tablet and is dried in time, the rotating speed of the coating pan can be reduced after the coating liquid is sprayed until the color of the surface of the tablet is uniform, and the tablet is taken out after heating and cooling to room temperature;

and S13, adding the tablets in the step 12 into a tablet packaging machine for packaging.

In the present embodiment

Wherein the air drying temperature in S2 is 60 ℃.

Wherein the drying temperature of the material in S7 is 50 ℃.

Wherein the rotating speed of the coating pan in S12 is controlled at 13 r/min.

Wherein the vacuum degree in S6 is 0.003 MPa, and the concentration temperature is 40 ℃.

Example 2

A thirst quenching and sugar reducing film coated tablet comprises the following components in parts by weight: 75 parts of guava leaves, 11 parts of corn starch, 7 parts of clear paste, 2.5 parts of 2 percent of talcum powder with particle amount, 7 parts of 0.5 percent of magnesium stearate, 3 parts of 5 to 10 percent of hydroxypropyl methylcellulose, 4 parts of 60 to 70 percent of ethanol, 1.5 parts of 0.8 to 1.2 percent of glycerol and 1.5 parts of 1.2 to 2.0 percent of red ferric oxide.

The corn starch content is the theoretical yield minus the extract weight multiplied by the extract solids content.

In addition, in order to solve the problems, the invention also provides a preparation method of the thirst quenching and blood sugar reducing film-coated tablet, which comprises the following steps:

s1, cleaning, namely cleaning the guava leaves in proper weight parts, and controlling water for 25 minutes;

s2, air-drying, namely, putting the guava leaves in the step 1 into an air dryer to air-dry for 24 hours at a low temperature;

s3, crushing, namely putting the guava leaves air-dried in the step 2 into a crusher for crushing;

s4, water extraction, namely pouring the guava leaf powder obtained in the step 3 into a marmite, adding clear water to immerse the medicinal materials, soaking for a proper time, heating to boil, keeping slightly boiling for a certain time, separating and decocting medicinal liquid, decocting medicinal residues for 2 times according to a method until the decoction is light in flavor, combining the decocted liquid for each time, and stirring;

s5, carrying out alcohol precipitation, namely cooling the liquid medicine in the step 4 to room temperature, adding the liquid medicine into an alcohol precipitation tank, adding an appropriate amount of 60-70% ethanol, stirring, transferring the mixture into a cold storage, standing the mixture at 8 ℃ for 36 hours, and extracting supernatant;

s6, concentrating, namely adding a proper amount of corn starch into the liquid medicine obtained in the step 5, fully stirring, adding into a low-temperature vacuum concentration tank, and concentrating into thick paste;

s7, granulating, namely putting the thick paste obtained in the step 6 into a dryer, adding the corn starch with the prescription amount into a hopper of a boiling granulation dryer, and preheating for 10 minutes; spraying the clear paste, granulating, continuously drying the granules for 25 minutes after the clear paste is sprayed, controlling the water content within 6 percent, taking out of the pot, sampling, and carrying out granule intermediate inspection;

s8, finishing and sieving: pulverizing the prepared granules with a pulverizer with a screen with the aperture of 0.8mm, and grading;

s9, adding a proper amount of 2% talcum powder and a proper amount of 0.5% magnesium stearate into the qualified granules, and mixing for 33 minutes in a two-dimensional motion mixer;

s10, tabletting, namely putting the Chinese medicinal balls obtained in the step 9 into a tabletting machine for tabletting, tabletting according to the weight of the base sheet of 0.27 g/tablet, and controlling the weight difference within +/-6.5%;

s11, preparing a coating solution, selecting hydroxypropyl methyl cellulose as a film coating material, adding a proper amount of 60-70% ethanol to make the concentration of the coating material reach 3-4%, stirring to dissolve the coating material, filtering, adding 0.8-1.2% of glycerol and 1.2-2.0% of red ferric oxide into filtrate, stirring uniformly, grinding colloid, and sieving with a 100-mesh sieve to prepare the coating solution for later use;

s12, coating, namely adding the tablet obtained in the step 11 into a coating pan, heating to 45-55 ℃, wherein the rotating speed of the coating pan starts to be 14r/min, the rotating speed of the coating pan can be properly increased along with the progress of coating, the air pressure is controlled to be 5Pa, the spraying speed is controlled, so that the coating liquid is sprayed on the surfaces of the tablets and is dried in time, the rotating speed of the coating pan can be reduced after the coating liquid is sprayed until the colors of the surfaces of the tablets are uniform, and the tablets are taken out after heating and cooling to room temperature;

and S13, adding the tablets in the step 12 into a tablet packaging machine for packaging.

In the present embodiment

Wherein the air drying temperature in S2 is 70 ℃.

Wherein the drying temperature of the material in S7 is 70 ℃.

Wherein, the rotating speed of the coating pan in S12 is controlled at 14 r/min.

Wherein the vacuum degree in S6 is 0.003 MPa, and the concentration temperature is 45 ℃.

Example 3

A thirst quenching and sugar reducing film coated tablet comprises the following components in parts by weight: 80 parts of guava leaves, 12 parts of corn starch, 8 parts of clear paste, 3 parts of 2% of talcum powder, 8 parts of 0.5% magnesium stearate, 4 parts of 5-10% hydroxypropyl methyl cellulose, 5 parts of 60-70% ethanol, 2 parts of 0.8-1.2% glycerol and 2 parts of 1.2-2.0% red ferric oxide.

The corn starch content is the theoretical yield minus the extract weight multiplied by the extract solids content.

In addition, in order to solve the problems, the invention also provides a preparation method of the thirst quenching and blood sugar reducing film-coated tablet, which comprises the following steps:

s1, cleaning, namely cleaning the guava leaves in proper weight parts, and controlling water for 30 minutes;

s2, air-drying, namely, putting the guava leaves in the step 1 into an air dryer to air-dry for 24 hours at a low temperature;

s3, crushing, namely putting the guava leaves air-dried in the step 2 into a crusher for crushing;

s4, water extraction, namely pouring the guava leaf powder obtained in the step 3 into a marmite, adding clear water to immerse the medicinal materials, soaking for a proper time, heating to boil, keeping slightly boiling for a certain time, separating and decocting medicinal liquid, decocting medicinal residues for 2 times according to a method until the decoction is light in flavor, combining the decocted liquid for each time, and stirring;

s5, carrying out alcohol precipitation, namely cooling the liquid medicine in the step 4 to room temperature, adding the liquid medicine into an alcohol precipitation tank, adding an appropriate amount of 60-70% ethanol, stirring, transferring the mixture into a cold storage, standing the mixture at 10 ℃ for 48 hours, and extracting supernatant;

s6, concentrating, namely adding a proper amount of corn starch into the liquid medicine obtained in the step 5, fully stirring, adding into a low-temperature vacuum concentration tank, and concentrating into thick paste;

s7, granulating, namely putting the thick paste obtained in the step 6 into a dryer, adding the corn starch with the prescription amount, putting the mixture into a hopper of a boiling granulation dryer, and preheating for 15 minutes; spraying the clear paste, granulating, continuously drying the granules for 30 minutes after the clear paste is sprayed, controlling the water content within 6 percent, taking out of the pot, sampling, and carrying out granule intermediate inspection;

s8, finishing and sieving: pulverizing the prepared granules with a pulverizer with a screen with the aperture of 0.8mm, and grading;

s9, adding a proper amount of 2% talcum powder and a proper amount of 0.5% magnesium stearate into the qualified granules, and mixing for 35 minutes in a two-dimensional motion mixer;

s10, tabletting, namely putting the Chinese medicinal balls obtained in the step 9 into a tabletting machine for tabletting, tabletting according to the weight of the base sheet of 0.27 g/tablet, and controlling the weight difference within +/-6.5%;

s11, preparing a coating solution, selecting hydroxypropyl methyl cellulose as a film coating material, adding a proper amount of 60-70% ethanol to make the concentration of the coating material reach 3-4%, stirring to dissolve the coating material, filtering, adding 0.8-1.2% of glycerol and 1.2-2.0% of red ferric oxide into filtrate, stirring uniformly, grinding colloid, and sieving with a 100-mesh sieve to prepare the coating solution for later use;

s12, coating, namely adding the tablet obtained in the step 11 into a coating pan, heating to 55 ℃, wherein the rotating speed of the coating pan is 13r/min, the rotating speed of the coating pan can be properly increased along with the coating, the air pressure is controlled to be 6Pa, the spraying speed is controlled, so that the coating liquid is sprayed on the surface of the tablet and is dried in time, the rotating speed of the coating pan can be reduced after the coating liquid is sprayed until the color of the surface of the tablet is uniform, and the tablet is taken out after heating and cooling to room temperature;

and S13, adding the tablets in the step 12 into a tablet packaging machine for packaging.

In the present embodiment

Wherein the air drying temperature in S2 is 80 ℃.

Wherein the drying temperature of the material in S7 is 85 ℃.

Wherein the rotation speed of the coating pan in S12 is controlled at 15 r/min.

Wherein the vacuum degree in S6 is 0.003 MPa, and the concentration temperature is 50 ℃.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.