阅读说明：本技术 一种凝血分析装置及凝血分析方法 (Blood coagulation analysis device and blood coagulation analysis method ) 是由 陶思良 石德成 于 2020-12-25 设计创作，主要内容包括：本发明涉及医用血样检测检验器材领域,具体而言,涉及一种凝血分析装置及凝血分析方法。凝血分析装置包括固定座、压电陶瓷片、应变片和控制器；压电陶瓷片在固定座上,应变片在压电陶瓷片上,控制器分别与压电陶瓷片和应变片连接。凝血分析方法为：将压电陶瓷片的末端浸入血液样本中,驱动压电陶瓷片的末端以固定频率进行摆动,随血样的凝结,记录压电陶瓷片的振幅变化。本发明将压电陶瓷片进行固定后,控制器控制压电陶瓷片进行摆动,应变片用于检测压电陶瓷片的摆动情况,通过控制器将压电陶瓷片的摆动情况进行记录和输出,进而可以得到血样的凝血功能。整个过程使用方便,不依赖与设备的具体位置关系和设置状态,安装和调试维护均较为方便。(The invention relates to the field of medical blood sample detection and inspection equipment, in particular to a blood coagulation analysis device and a blood coagulation analysis method. The blood coagulation analysis device comprises a fixed seat, a piezoelectric ceramic piece, a strain gauge and a controller; the piezoelectric ceramic piece is arranged on the fixed seat, the strain gauge is arranged on the piezoelectric ceramic piece, and the controller is respectively connected with the piezoelectric ceramic piece and the strain gauge. The blood coagulation analysis method comprises the following steps: and immersing the tail end of the piezoelectric ceramic piece into the blood sample, driving the tail end of the piezoelectric ceramic piece to swing at a fixed frequency, and recording the amplitude change of the piezoelectric ceramic piece along with the coagulation of the blood sample. According to the invention, after the piezoelectric ceramic piece is fixed, the controller controls the piezoelectric ceramic piece to swing, the strain gauge is used for detecting the swing condition of the piezoelectric ceramic piece, and the swing condition of the piezoelectric ceramic piece is recorded and output through the controller, so that the blood coagulation function of a blood sample can be obtained. The whole process is convenient to use, does not depend on the specific position relation and the setting state of the equipment, and is convenient to install, debug and maintain.)

1. A blood coagulation analysis device is characterized by comprising a fixed seat, a piezoelectric ceramic piece, a strain gauge and a controller;

the piezoelectric ceramic piece is arranged on the fixed seat, the strain gauge is arranged on the piezoelectric ceramic piece, and the controller is respectively connected with the piezoelectric ceramic piece and the strain gauge.

2. The coagulation analyzer of claim 1, wherein the strain gauges are disposed on both of the oppositely disposed sides of the piezoelectric ceramic plate.

3. The coagulation analyzer of claim 1, wherein one end of the piezoelectric ceramic plate is fixedly arranged on the fixing seat, and the other end of the piezoelectric ceramic plate is used for swinging under the control of the controller.

4. The coagulation analyzer as claimed in claim 3, wherein the piezoelectric ceramic plate is fixedly connected to the fixing base by adhesion.

5. The coagulation analyzer of claim 1, wherein the holder is provided with a connection structure for positioning the holder.

6. The coagulation analyzer of claim 5, wherein the attachment structure is a bolt.

7. The coagulation analyzer of claim 1, wherein the controller comprises a drive module and a storage module;

the driving module is connected with the piezoelectric ceramic piece and used for driving the piezoelectric ceramic piece to swing;

the storage module is connected with the strain gauge and used for recording a change signal of the strain gauge.

8. The coagulation analyzing method according to any one of claims 1 to 7, wherein the tip of the piezoelectric ceramic plate is immersed in a blood sample, and the tip of the piezoelectric ceramic plate is driven to oscillate at a fixed frequency, and the amplitude change of the piezoelectric ceramic plate is recorded as the blood sample coagulates.

9. The coagulation analysis method according to claim 8, wherein the piezoelectric ceramic sheet is driven at a fixed frequency by: driving is done using a sinusoidal voltage.

10. The coagulation analysis method according to claim 8, wherein the amplitude change of the piezoelectric ceramic sheet is recorded in a manner that: and when the strain gauge swings along with the piezoelectric ceramic piece, recording the voltage or resistance change of the strain gauge.

Technical Field

The invention relates to the field of medical blood sample detection and inspection equipment, in particular to a blood coagulation analysis device and a blood coagulation analysis method.

Background

The thromboelastogram is an analyzer for monitoring the blood coagulation process from the whole dynamic process of platelet aggregation, blood coagulation, fibrinolysis and the like, and the principle of the thromboelastogram is that whether the thromboelastogram has normal blood coagulation function or not is determined for the physical characteristics (blood clot strength and stability) of the formed blood clot based on the final result of the blood coagulation process.

The sampling probe of blood sample is the key sensor subassembly that detects blood coagulation state change data with time, and traditional test probe adopts the cup rotatory, and the test probe that hangs through the suspension wire detects passive rotatory angle and realizes detecting the blood coagulation index of blood, but traditional structure during operation, must keep absolute level, and the use of instrument, installation and debugging maintain very troublesome.

Disclosure of Invention

The invention aims to provide a coagulation analysis device and a coagulation analysis method, which can realize the analysis of coagulation function by detecting the amplitude change of a piezoelectric ceramic piece, do not need to depend on the position state of equipment, and are very convenient to use, install, debug and maintain.

The embodiment of the invention is realized by the following steps:

in a first aspect, the invention provides a blood coagulation analyzer, which comprises a fixed seat, a piezoelectric ceramic piece, a strain gauge and a controller;

the piezoelectric ceramic piece is arranged on the fixed seat, the strain gauge is arranged on the piezoelectric ceramic piece, and the controller is respectively connected with the piezoelectric ceramic piece and the strain gauge.

In an alternative embodiment, the strain gauges are disposed on two opposite side surfaces of the piezoelectric ceramic sheet.

In an optional implementation manner, one end of the piezoelectric ceramic piece is fixedly arranged on the fixing seat, and the other end of the piezoelectric ceramic piece is used for swinging under the control of the controller.

In an optional embodiment, the piezoelectric ceramic plate is fixedly connected with the fixed seat in an adhesion manner.

In an optional embodiment, a connection structure is disposed on the fixing base, and the connection structure is used for positioning the position of the fixing base.

In an alternative embodiment, the attachment structure is a bolt.

In an alternative embodiment, the controller includes a drive module and a storage module;

the driving module is connected with the piezoelectric ceramic piece and used for driving the piezoelectric ceramic piece to swing;

the storage module is connected with the strain gauge and used for recording a change signal of the strain gauge.

In a second aspect, the present invention provides a coagulation analysis method based on any one of the coagulation analysis apparatuses described above, in which the end of the piezoelectric ceramic piece is immersed in a blood sample, the end of the piezoelectric ceramic piece is driven to oscillate at a fixed frequency, and the amplitude change of the piezoelectric ceramic piece is recorded as the blood sample coagulates.

In an alternative embodiment, the way to drive the piezoceramic wafer at a fixed frequency is: driving is done using a sinusoidal voltage.

In an alternative embodiment, the manner of recording the amplitude change of the piezoelectric ceramic plate is as follows: and when the strain gauge swings along with the piezoelectric ceramic piece, recording the voltage or resistance change of the strain gauge.

The embodiment of the invention has the beneficial effects that:

after the piezoelectric ceramic piece is fixed through the fixing seat, the controller controls the piezoelectric ceramic piece to swing, the strain gauge is used for detecting the swing condition of the piezoelectric ceramic piece, the swing condition of the piezoelectric ceramic piece is recorded and output through the controller, and then the blood coagulation function of a blood sample can be obtained. The whole process is convenient to use, does not depend on the specific position relation and the setting state of the equipment, and is convenient to install, debug and maintain.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

FIG. 1 is a schematic structural diagram of a coagulation analyzer according to an embodiment of the present invention;

fig. 2 is a schematic diagram illustrating a swing state of a piezoelectric ceramic plate of the blood coagulation analyzer according to an embodiment of the present invention;

fig. 3 is a circuit diagram of a wheatstone bridge of a controller of a coagulation analyzer according to an embodiment of the present invention.

Icon: 1-a piezoelectric ceramic sheet; 2-strain gauge; 3-detecting the cup; 4-a controller; 5-fixing the base; 6-blood sample.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Some embodiments of the invention are described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

The invention provides a blood coagulation analysis device, which comprises a fixed seat 5, a piezoelectric ceramic piece 1, a strain gauge 2 and a controller 4, wherein the fixed seat is provided with a plurality of grooves; the piezoelectric ceramic piece 1 is arranged on the fixed seat 5, the strain gauge 2 is arranged on the piezoelectric ceramic piece 1, and the controller 4 is respectively connected with the piezoelectric ceramic piece 1 and the strain gauge 2.

In this embodiment, piezoceramics piece 1 is fixed to be set up on fixing base 5, and the tip can carry out the vibration of certain range under the control of controller 4, the laminating of foil gage 2 sets up on piezoceramics piece 1's surface, when piezoceramics piece 1 changes the shape because of the vibration, foil gage 2 can receive different pressures because of piezoceramics piece 1's vibration, and then produce different voltage or resistance changes, controller 4 carries out the record to the voltage or the resistance change of foil gage 2, after concluding the arrangement with the peak value that changes, can obtain piezoceramics piece 1's vibration peak value change, and then change according to piezoceramics piece 1's vibration peak value, can obtain the blood coagulation function of the blood sample 6 of analysis.

Specifically, the strain gauge 2 is an element for measuring strain, which is constituted by a sensitive grid or the like; the working principle of the resistance strain gage 2 is based on the strain effect, that is, when a conductor or a semiconductor material is mechanically deformed under the action of external force, the resistance value of the conductor or the semiconductor material is correspondingly changed, and the phenomenon is called the strain effect.

The piezoelectric effect is only related to the electric field, and the piezoelectric ceramic piece 1 does not generate a magnetic field and is not influenced by the magnetic field.

In a specific use, one end of the piezoelectric ceramic plate 1, which generates vibration, is inserted into the blood sample 6 in the detection cup 3, and the controller 4 drives the piezoelectric ceramic plate 1 to vibrate at a fixed frequency. When the blood sample 6 begins to coagulate, the viscosity and elasticity of the blood sample 6 gradually increase, which means that the resistance of one end of the piezoelectric ceramic piece 1 inserted into the blood sample 6 of the detection cup 3 during vibration gradually increases, the amplitude gradually decreases under the condition that the vibration frequency is unchanged, the voltage signal detected by the strain gauge 2 gradually decreases, the controller 4 records the voltage signal change of the strain gauge 2, calculates the amplitude change of the piezoelectric ceramic piece 1 according to the peak value change, and then obtains the coagulation characteristic of the blood sample 6 according to the amplitude change of the piezoelectric ceramic piece 1.

In this embodiment, since the driving of the piezoelectric ceramic is driven by an electrical signal, the swing frequency and the moment of the piezoelectric ceramic can be controlled by only controlling the frequency and the voltage of the driving signal, the elastic characteristic of the sample can be measured usually in the low-frequency driving, the viscosity characteristic of the sample can be measured in the medium-frequency signal driving, and the cleaning and self-cleaning functions can be realized in the high-frequency driving.

The piezoelectric ceramic actuator can directly convert electric energy and mechanical energy, can realize motion in a sub-nanometer range, and has no friction element for limiting resolution, so that the resolution is high and the repeatability is good.

Even if a heavy load is carried for a long time, the static operation does not actually consume any energy. The piezoelectric actuator operates much like a capacitor and does not generate heat when not operating, and therefore does not change the temperature of the sample being measured and affect the measurement.

The piezoelectric ceramic piece 1 does not have moving parts such as gears and bearings, the displacement of the piezoelectric ceramic piece is based on crystal solid-state dynamics, and the piezoelectric ceramic piece 1 in the embodiment passes hundreds of millions of endurance tests, and the characteristics of the piezoelectric ceramic piece have no obvious change.

In an alternative embodiment, the strain gauges 2 are disposed on two opposite sides of the piezoelectric ceramic plate 1.

By arranging the strain gauges 2 on the two opposite sides of the piezoelectric ceramic piece 1 and detecting the two opposite sides of the piezoelectric ceramic piece 1 simultaneously, the detection precision of the piezoelectric ceramic piece 1 can be improved, and the accuracy of a detection result is ensured.

Similarly, in the alternative embodiment of the present invention, at least two strain gauges 2 are disposed on each side surface of the piezoelectric ceramic plate 1, so that the detection accuracy of the piezoelectric ceramic plate 1 can also be improved.

The strain gauges 2 arranged on the two opposite sides of the piezoelectric ceramic piece 1 are arranged in parallel, the strain gauges 2 on the same side are arranged in series to form a Wheatstone bridge, and the bending amplitude change of the piezoelectric ceramic piece 1 can be accurately provided.

It should be noted that, in the present embodiment, the number of the strain gauges 2 is two on the front side and the rear side of the piezoelectric ceramic plate 1, but the present invention is not limited to this arrangement, and only two strain gauges 2 or only one strain gauge 2 may be arranged according to the cost, as long as the bending detection of the piezoelectric ceramic plate 1 can be realized through the strain gauges 2.

In an alternative embodiment, the strain gauge 2 is completely attached to the piezoceramic wafer 1.

With such an arrangement, the detection range of the strain gauge 2 can be increased, and the detection accuracy of the piezoelectric ceramic sheet 1 can be improved.

Specifically, in the present embodiment, the strain gauge 2 is bonded to the piezoelectric ceramic sheet 1.

It should be noted that, the connection manner between the strain gauge 2 and the piezoelectric ceramic plate 1 may be bonding, but is not limited to bonding, and it may also be other fixed connection manners, as long as the strain gauge 2 can be attached to the piezoelectric ceramic plate 1, and the bending deformation of the piezoelectric ceramic plate 1 can be detected through the strain gauge 2.

In an alternative embodiment, as shown in fig. 2, one end of the piezoelectric ceramic plate 1 is fixedly disposed on the fixing base 5, and the other end of the piezoelectric ceramic plate 1 is configured to swing under the control of the controller 4.

In this embodiment, the position where the piezoelectric ceramic plate 1 and the fixing base 5 are fixed is the end of the piezoelectric ceramic plate 1, and such an arrangement can maximize the amplitude of vibration generated when the other end of the piezoelectric ceramic plate 1 swings, so that the detection result is the most accurate.

In an alternative embodiment, the fixing connection between the piezoelectric ceramic plate 1 and the fixing base 5 is bonding.

In this embodiment, the end of the piezoelectric ceramic plate 1 is disposed on the fixing base 5 by bonding, and the end face of the end may be connected to the fixing base 5, or the side face of the end may be connected to the fixing base 5.

It should be noted that, in the present embodiment, the piezoelectric ceramic plate 1 and the fixing base 5 may be connected by bonding, but the present invention is not limited to the bonding, and other connection methods may also be used, such as clamping, etc., that is, only one end of the piezoelectric ceramic plate 1 can be fixedly disposed on the fixing base 5.

In an alternative embodiment, the fixing base 5 is provided with a connecting structure, and the connecting structure is used for positioning the position of the fixing base 5.

In this embodiment, the connection structure that sets up on fixing base 5 can be with fixing base 5 connection setting on other objects, also can be with fixing base 5 fixed setting in positions such as ground, wall for fixing base 5 can be stable motionless, and then guarantee at the in-process to blood specimen 6 detection, piezoceramics piece 1's vibration stability, and the accuracy that foil gage 2 detected.

Specifically, in this embodiment, the fixing base 5 is disposed on other devices through a connecting structure.

More specifically, in this embodiment, at least two through holes are provided on the fixing base 5, and after one end of the bolt passes through the through hole and then passes through the device to be fixed, the bolt is fixed through the nut, thereby achieving the purpose of fixing the fixing base 5.

It should be noted that, in the present embodiment, the connection structure is a bolt, but it is not limited to a bolt, and it may also be other devices, such as a snap-in structure, a pin connection structure, etc., that is, as long as the fixing base 5 can be disposed on other devices or fixed at a certain position.

In an alternative embodiment, the controller 4 comprises a drive module and a storage module; the driving module is connected with the piezoelectric ceramic piece 1 and is used for driving the piezoelectric ceramic piece 1 to swing; the storage module is connected with the strain gauge 2 and used for recording the change signal of the strain gauge 2.

In this embodiment, the controller 4 is mainly divided into two parts, one of which is a driving module for driving the piezoelectric ceramic plate 1 to swing.

Specifically, in this embodiment, the specific structure of the driving module may be a driving circuit.

The driving circuit comprises positive driving and negative driving, namely when the driving voltage output by the driving circuit is positive voltage, the driving circuit can drive the end part of the piezoelectric ceramic piece 1 to swing towards one direction; when the output driving voltage of the driving circuit is negative voltage, the driving circuit drives the end of the piezoelectric ceramic plate 1 to swing in the opposite direction.

In this embodiment, the alternating frequencies of the driving voltages output by the driving circuits are the same, and the peak values are the same, that is, the output voltage of the driving circuits is a sine voltage or a cosine voltage.

In this embodiment, the memory module is a wheatstone bridge.

Specifically, the wheatstone bridge is a bridge circuit composed of four resistors, the four resistors are respectively called as bridge arms of the bridge, the wheatstone bridge measures the change of the physical quantity by using the change of the resistors, the single chip microcomputer collects the voltages at the two ends of the variable resistors and then processes the voltages, the corresponding change of the physical quantity can be calculated, and the method is a measuring mode with high precision.

More specifically, in the present embodiment, as shown in fig. 3, in the present embodiment, four resistors R of the wheatstone bridge₁、R₂、R₃And R₄The four strain gauges 2 are respectively arranged on the piezoelectric ceramic piece 1, when the piezoelectric ceramic piece 1 swings, the voltage or the resistance of the strain gauge 2 changes, and then the change of the peak value of the corresponding piezoelectric ceramic piece 1 is obtained according to calculation.

The invention provides a blood coagulation analysis method, which comprises the steps of immersing the tail end of a piezoelectric ceramic piece 1 into a blood sample, driving the piezoelectric ceramic piece 1 to swing at a fixed frequency, and recording the amplitude change of the piezoelectric ceramic piece 1 along with the coagulation of the blood sample.

In this embodiment, the whole process is simple, and the device does not need to be strictly adjusted, so long as the swing frequency of the piezoelectric ceramic plate 1 is fixed, and the amplitude change of the piezoelectric ceramic plate 1 can be recorded.

In an alternative embodiment, the way to drive the piezoceramic wafer 1 at a fixed frequency is: driving is done using a sinusoidal voltage.

When the sinusoidal voltage drives the piezoelectric ceramic plate 1, the maximum voltage and the minimum voltage are always unchanged, and the change frequency of the voltage is the same, so that when the peak value of the amplitude of the piezoelectric ceramic plate 1 changes, only after the blood sample 6 generates viscosity due to blood coagulation, the resistance generated to the piezoelectric ceramic plate 1 changes, and then the analysis and detection result of the blood coagulation performance of the blood sample 6 can be realized through the variable.

In an alternative embodiment, the way of recording the amplitude change of the piezoelectric ceramic sheet 1 is as follows: the strain gauge 2 is arranged on the piezoelectric ceramic piece 1, and when the strain gauge 2 swings along with the piezoelectric ceramic piece 1, the voltage or resistance change of the strain gauge 2 is recorded.

The change in the resistance or voltage of the strain gauge 2 can reflect the change in the oscillation of the piezoelectric ceramic sheet 1. When the resistance or the voltage of the strain gauge 2 reaches the maximum value or the minimum value, the peak value of the piezoelectric ceramic piece 1 in the positive direction or the peak value in the negative direction can be obtained.

And then the change of the resistance received by the piezoelectric ceramic piece 1 can be obtained through the change of the peak value, and further the analysis and detection result of the blood coagulation performance of the blood sample 6 can be obtained according to the change of the resistance.

The embodiment of the invention has the beneficial effects that:

after the piezoelectric ceramic piece 1 is fixed through the fixing seat 5, the controller 4 controls the piezoelectric ceramic piece 1 to swing, the strain gauge 2 is used for detecting the swing condition of the piezoelectric ceramic piece 1, the swing condition of the piezoelectric ceramic piece 1 is recorded and output through the controller 4, and then the blood coagulation function of the blood sample 6 can be obtained. The whole process is convenient to use, does not depend on the specific position relation and the setting state of the equipment, and is convenient to install, debug and maintain.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.