阅读说明：本技术 牙源干细胞及其用途 (Odontogenic stem cells and uses thereof ) 是由 孟虹芳 王�华 吴祖泽 唐仲雄 于 2018-11-22 设计创作，主要内容包括：干细胞和基因修饰的干细胞的用途。特别是牙源干细胞和基因修饰的牙源干细胞在制备用于治疗银屑病及相关疾病的产品中的用途。包含牙源干细胞和/或基因修饰的牙源干细胞的组合物或试剂盒。HGF基因修饰的牙髓干细胞治疗银屑病的作用优于牙髓干细胞,HGF和牙源干细胞可以协同用于银屑病相关疾病的治疗。(Use of stem cells and genetically modified stem cells. In particular to the use of the odontogenic stem cells and the genetically modified odontogenic stem cells in the preparation of products for treating psoriasis and related diseases. A composition or kit comprising a dental stem cell and/or a genetically modified dental stem cell. The HGF gene modified dental pulp stem cells have better effect on treating psoriasis than the dental pulp stem cells, and the HGF and the dental source stem cells can be cooperatively used for treating psoriasis-related diseases.)

Use of stem cells in the manufacture of a product for the treatment of a psoriasis-associated disease.

Use according to claim 1, wherein the stem cells are preferably dental or umbilical cord stem cells, more preferably genetically modified dental stem cells.

Stem cells, wherein the stem cells are selected from one or more of dental pulp stem cells, deciduous tooth dental pulp stem cells, periodontal ligament stem cells and apical tooth papilla stem cells, and umbilical cord stem cells.

The stem cell of claim 3, wherein the stem cell is obtained by introducing an exogenous hepatocyte growth factor into the stem cell and expressing the exogenous hepatocyte growth factor.

A composition comprising a therapeutically effective amount of the stem cells of claim 3 or 4 and optionally a pharmaceutically acceptable carrier or excipient.

The composition of claim 5, which is a physiological saline suspension of stem cells.

A kit comprising the stem cell of claim 3 or 4 or the composition of claim 5 or 6.

Use of hepatocyte growth factor in the manufacture of a product for reducing inflammatory factors, treating psoriasis related diseases.

The use of claim 7, wherein the hepatocyte growth factor is human hepatocyte growth factor.

A method of preparing the stem cell of claim 3 or 4, the composition of claim 5 or 6, the kit of claim 7.