阅读说明：本技术 一种复合材料及其制备方法、应用 (Composite material and preparation method and application thereof ) 是由 肖颖 王荣 顾钦玮 黄智懋 于 2020-12-09 设计创作，主要内容包括：本申请公开了一种复合材料及其制备方法、应用。所述复合材料包括化合物A和超高分子量聚乙烯；所述化合物A粘附在所述超高分子量聚乙烯表面；所述化合物A选自金属配位化合物；所述金属配位化合物中的金属离子选自铜离子、锌离子中的至少一种；配体来自多酚类化合物。本申请利用含有多酚官能团的有机小分子化学物作为“桥梁”,一方面酚羟基能和具有抗菌性能的金属离子形成配位键,另一方面大量的酚羟基通过范德华力与基体结合,同时实现对抗菌金属离子的络合及对基体材料的涂覆,对超高分子量聚乙烯表面进行抗菌涂层改性,使超高分子量聚乙烯表面涂覆具有抗菌性能的金属离子,从而实现超高分子量聚乙烯材料的抗菌功能。(The application discloses a composite material and a preparation method and application thereof. The composite material comprises a compound A and ultra-high molecular weight polyethylene; the compound A is adhered to the surface of the ultra-high molecular weight polyethylene; the compound A is selected from metal coordination compounds; the metal ion in the metal coordination compound is at least one selected from copper ion and zinc ion; the ligand is derived from a polyphenol compound. According to the method, an organic small molecular chemical containing a polyphenol functional group is used as a bridge, on one hand, phenolic hydroxyl groups can form coordinate bonds with metal ions with antibacterial performance, on the other hand, a large number of phenolic hydroxyl groups are combined with a matrix through van der Waals force, meanwhile, the complexing of antibacterial metal ions and the coating of the matrix material are achieved, the antibacterial coating modification is carried out on the surface of the ultra-high molecular weight polyethylene, the metal ions with the antibacterial performance are coated on the surface of the ultra-high molecular weight polyethylene, and therefore the antibacterial function of the ultra-high molecular weight polyethylene material is achieved.)

1. A composite material, characterized in that it comprises compound a and ultra-high molecular weight polyethylene;

the compound A is adhered to the surface of the ultra-high molecular weight polyethylene;

the molecular weight of the ultra-high molecular weight polyethylene is 100-500 ten thousand;

the compound A is selected from metal coordination compounds; the metal ion in the metal coordination compound is at least one selected from copper ion and zinc ion; the ligand is derived from a polyphenol compound.

2. The composite material according to claim 1, wherein the polyphenolic compound is selected from at least one of tannic acid, dopamine, catechol, pyrogalloc acid, noradrenaline.

3. A method for preparing a composite material according to claim 1 or 2, characterized in that it comprises:

and reacting and adhering a mixture containing the ultrahigh molecular weight polyethylene, the metal ion source and the polyphenol compound to obtain the composite material.

4. The preparation method according to claim 3, wherein the mass ratio of the metal ion source to the polyphenol compound is 100:2.5 to 100: 40.

5. The production method according to claim 3, wherein the metal ion source is at least one selected from a copper ion source and a zinc ion source;

the copper ion source is selected from at least one of copper salts;

the zinc ion source is selected from at least one of zinc salts;

preferably, the copper salt is selected from at least one of copper nitrate, copper chloride and copper sulfate;

the zinc salt is selected from at least one of zinc nitrate, zinc chloride and zinc sulfate.

6. The method of manufacturing according to claim 3, comprising:

(1) adhering a material I containing ultra-high molecular weight polyethylene and a polyphenol compound to obtain an intermediate product;

(2) and reacting the material II containing the intermediate product and the metal ion source to obtain the composite material.

7. The production method according to claim 6, wherein in the step (1), the conditions for the adhesion are: the temperature is 20-70 ℃; the time is 5-48 hours;

in the step (2), the reaction conditions are as follows: the temperature is 20-70 ℃; the time is 10 to 48 hours.

8. The method of claim 6, wherein the step (1) comprises: obtaining a material I containing ultra-high molecular weight polyethylene and a polyphenol compound, adjusting the pH value of the material I, and allowing the polyphenol compound to self-polymerize and adhere to the surface of the ultra-high molecular weight polyethylene through a non-covalent bond effect to obtain an intermediate product;

preferably, said adjusting the pH of said material I comprises: adjusting the pH of the material I to 7.5-12 by using a pH adjusting solution;

preferably, the pH adjusting solution is at least one selected from Tris-HCl buffer solution, PBS buffer solution, boric acid-borax buffer solution, sodium hydroxide solution and potassium hydroxide solution;

preferably, in the material II, a solvent is also included; the solvent is selected from water;

preferably, in the material II, the mass ratio of the metal ion source to the solvent is 1: 100-1: 25.

9. An antimicrobial material selected from any one of the composite material of claim 1 or 2, or a composite material prepared by the method of any one of claims 3 to 8.

10. Use of the antibacterial material according to claim 9 in an artificial joint material.

Technical Field

The application belongs to the field of ultra-high molecular weight polyethylene, and particularly relates to a composite material and a preparation method and application thereof.

Background

The ultra-high molecular weight polyethylene is a linear plastic engineering plastic with the molecular weight of more than 100 ten thousand, and has the characteristics of light weight, good waterproofness, good chemical corrosion resistance, high impact resistance, high wear resistance, biological inertia and the like. Due to the outstanding mechanical property, good wear resistance and excellent biocompatibility of the ultra-high molecular weight polyethylene, the material is widely applied to artificial joint materials. However, the problem still exists when the ultra-high molecular weight polyethylene is used as an artificial joint material, and the ultra-high molecular weight polyethylene material is a biological inert material and has no antibacterial performance. After the artificial joint replacement is completed, the patient has the risk of bacterial infection, so that the ultrahigh molecular weight polyethylene material needs to be treated, so that the ultrahigh molecular weight polyethylene material has antibacterial performance and realizes a quick and efficient sterilization function. Currently, for the research on the antibacterial performance of polymer biomedical materials, antibacterial agents are mostly directly added into a polymer matrix to prepare the biomedical materials with the antibacterial performance. The method is simple to operate, the addition amount of the antibacterial agent can be accurately controlled, but the dispersion of the antibacterial agent in the polymer matrix material is limited by the compatibility of the polymer matrix material and the antibacterial agent and the processing technology. The phenomenon of uneven dispersion is easy to occur in the processing process of the antibacterial agent, and the prepared medical material has poor antibacterial performance. Meanwhile, part of the organic micromolecule antibacterial agent has poor heat resistance, is easy to be decomposed and lose efficacy at high temperature in the processing process, and loses the antibacterial effect. Therefore, it is necessary to develop a new antibacterial modification method to improve the antibacterial performance of the polymer material.

Disclosure of Invention

The invention aims to provide a method for preparing an antibacterial ultrahigh molecular weight polyethylene block by taking antibacterial metal ions as a surface coating antibacterial agent aiming at the defects of the prior art.

According to a first aspect of the present application, there is provided a composite material comprising compound a and ultra high molecular weight polyethylene;

the compound A is adhered to the surface of the ultra-high molecular weight polyethylene through non-covalent bond;

the molecular weight of the ultra-high molecular weight polyethylene is 100-500 ten thousand;

the compound A is selected from metal coordination compounds; the metal ion in the metal coordination compound is at least one selected from copper ion and zinc ion; the ligand is derived from a polyphenol compound.

Optionally, the polyphenolic compound is selected from at least one of tannic acid, dopamine, catechol, pyrogalloc acid, noradrenaline.

According to a second aspect of the present application, there is provided a method of preparing the above composite material, the method comprising:

and reacting and adhering a mixture containing the ultrahigh molecular weight polyethylene, the metal ion source and the polyphenol compound to obtain the composite material.

Optionally, the mass ratio of the metal ion source to the polyphenol compound is 100: 2.5-100: 40.

Optionally, the upper mass ratio limit of the metal ion source and the polyphenolic compound is independently selected from the group consisting of 100:2.5, 100: 5. 100, and (2) a step of: 10. 100, and (2) a step of: 20. 100:30, 100: 35, the lower limit is independently selected from 100: 40. 100, and (2) a step of: 5. 100, and (2) a step of: 10. 100, and (2) a step of: 20. 100:30, 100: 35.

optionally, the metal ion source is selected from at least one of a copper ion source, a zinc ion source;

the copper ion source is selected from at least one of copper salts;

the zinc ion source is selected from at least one of zinc salts;

preferably, the copper salt is selected from at least one of copper nitrate, copper chloride and copper sulfate;

the zinc salt is selected from at least one of zinc nitrate, zinc chloride and zinc sulfate.

Optionally, the method comprises:

(1) adhering a material I containing ultra-high molecular weight polyethylene and a polyphenol compound to obtain an intermediate product;

(2) and reacting the material II containing the intermediate product and the metal ion source to obtain the composite material.

Optionally, in the step (1), the adhering conditions are: the temperature is 20-70 ℃; the time is 5-48 hours;

in the step (2), the reaction conditions are as follows: the temperature is 20-70 ℃; the time is 10 to 48 hours.

Optionally, the upper temperature limit of the adhesion is independently selected from 70 ℃, 50 ℃, 40 ℃, 30 ℃, and the lower temperature limit is independently selected from 20 ℃, 50 ℃, 40 ℃, 30 ℃.

Alternatively, the upper time limit for the adhesion is independently selected from 48 hours, 42 hours, 38 hours, 32 hours, 28 hours, 22 hours, 18 hours, and the lower time limit is independently selected from 5 hours, 42 hours, 38 hours, 32 hours, 28 hours, 22 hours, 18 hours.

Alternatively, the upper temperature limit of the reaction is independently selected from 70 ℃, 50 ℃, 40 ℃, 30 ℃, and the lower temperature limit is independently selected from 20 ℃, 50 ℃, 40 ℃, 30 ℃.

Alternatively, the upper time limit of the reaction is independently selected from 48 hours, 42 hours, 38 hours, 32 hours, 28 hours, 22 hours, 18 hours, and the lower time limit is independently selected from 10 hours, 42 hours, 38 hours, 32 hours, 28 hours, 22 hours, 18 hours.

Optionally, the step (1) comprises: obtaining a material I containing the ultra-high molecular weight polyethylene and the polyphenol compound, adjusting the pH value of the material I, and allowing the polyphenol compound to self-polymerize and adhere to the surface of the ultra-high molecular weight polyethylene through non-covalent bond action to obtain the intermediate product.

Optionally, the adjusting the pH of the material I comprises: adjusting the pH value of the material I to 7.5-12 through a pH regulator;

preferably, the pH regulator is at least one selected from Tris-HCl buffer solution, PBS buffer solution, boric acid-borax buffer solution, sodium hydroxide solution and potassium hydroxide solution.

Optionally, in the material II, a solvent is further included; the solvent is selected from water.

Optionally, in the material II, the mass ratio of the metal ion source to the solvent is 1: 100-1: 25.

Optionally, the method comprises:

and (1) sequentially carrying out ultrasonic treatment on the ultrahigh molecular weight polyethylene block in deionized water and ethanol for 30-120 minutes at normal temperature to remove pollutants on the surface of the ultrahigh molecular weight polyethylene block. And taking out the block after the ultrasonic treatment, and drying the surface of the block by using nitrogen to obtain a dry and clean ultrahigh molecular weight polyethylene block.

And (2) placing the ultra-high molecular weight polyethylene block in a pH adjusting solution of a small molecular compound containing a polyphenol functional group, shaking at a constant speed for 6-48 hours at 25-70 ℃, taking out, washing with deionized water for 2 times, placing in deionized water, performing ultrasonic treatment for 30-60 minutes, and drying the surface of the block with nitrogen to obtain the polyphenol surface modified ultra-high molecular weight polyethylene block.

And (3) placing the polyphenol surface modified ultra-high molecular weight polyethylene block into an aqueous solution of a compound containing antibacterial metal ions, shaking at a constant speed for 12-48 hours at 25-70 ℃, taking out, washing with deionized water for 2 times, placing in deionized water, performing ultrasonic treatment for 30-60 minutes, and drying the surface of the block with nitrogen to obtain the antibacterial ultra-high molecular weight polyethylene block.

Optionally, the mass ratio of the polyphenol compound to the pH adjusting solution is 1: 1000-1: 250.

According to a third aspect of the present application there is provided an antimicrobial material selected from any one of the above-described composite materials, and composite materials prepared according to the above-described method.

According to a final aspect of the application, there is provided the use of an antimicrobial material as described above in an artificial joint material.

According to the method, an organic small molecular chemical containing a polyphenol functional group is used as a bridge, on one hand, phenolic hydroxyl groups can form coordinate bonds with metal ions with antibacterial performance, on the other hand, a large number of phenolic hydroxyl groups are combined with a matrix through van der Waals force, meanwhile, the complexing of antibacterial metal ions and the coating of the matrix material are achieved, the antibacterial coating modification is carried out on the surface of the ultra-high molecular weight polyethylene, the metal ions with the antibacterial performance are coated on the surface of the ultra-high molecular weight polyethylene, and therefore the antibacterial function of the ultra-high molecular weight polyethylene material is achieved.

The beneficial effects that this application can produce include at least:

the method adopts a small molecular compound (polyphenol compound) containing polyphenol functional groups as a bridge to prepare the novel antibacterial ultrahigh molecular weight polyethylene block. Compared with the unmodified ultra-high molecular weight polyethylene block, the antibacterial property of the antibacterial ultra-high molecular weight polyethylene block prepared by the method is obviously improved. The method has simple preparation process and mild reaction conditions, and can be widely applied to the antibacterial modification of the ultra-high molecular weight polyethylene block.

Detailed Description

The present application is further illustrated below with reference to specific examples. The following description is only exemplary of the present application and should not be taken as limiting the present application in any way, and although the present application is disclosed as the following preferred embodiments, the present application is not limited thereto, and those skilled in the art can make modifications and variations of the present application without departing from the scope of the present application.

Unless otherwise specified, the raw materials in the examples of the present application were purchased commercially and used without any special treatment.

The analysis method in the examples of the present application is as follows:

and characterizing the surface elements of the ultrahigh molecular weight polyethylene before and after modification by an X-ray photoelectron spectrum analyzer.

In the embodiment of the application, surface elements before and after modification of the ultra-high molecular weight polyethylene are characterized by an X-ray photoelectron spectrometer. And (3) performing antibacterial performance characterization on the modified ultrahigh molecular weight polyethylene block and the unmodified ultrahigh molecular weight polyethylene block by referring to the method of international standard ISO 22196. Staphylococcus aureus is selected as an experimental strain, and a plate colony counting method is adopted to represent the antibacterial performance of the sample before and after modification.

Example 1

And (1) sequentially carrying out ultrasonic treatment on the ultra-high molecular weight polyethylene block with the molecular weight of 200 ten thousand in deionized water and ethanol for 60 minutes at normal temperature to remove pollutants on the surface of the ultra-high molecular weight polyethylene block. And taking out the block after the ultrasonic treatment, and drying the surface of the block by using nitrogen to obtain a dry and clean ultrahigh molecular weight polyethylene block.

And (2) placing the ultrahigh molecular weight polyethylene block (with the size of 60 mm x 20 mm x 2 mm) in a pH adjusting solution of tannic acid (prepared by placing 0.1g of tannic acid in 50mL of the pH adjusting solution), wherein the mass ratio of tannic acid to the pH adjusting solution in the tannic acid solution is 1:500, the pH adjusting solution is a Tris-HCl buffer solution, adjusting the pH value to 7.5, oscillating at 30 ℃ for 22 hours at constant speed, taking out, washing with deionized water for 2 times, placing in deionized water for ultrasonic treatment for 30 minutes, removing residual tannic acid molecules on the surface of the ultrahigh molecular weight polyethylene, and drying the surface of the block with nitrogen to obtain the polyphenol surface modified ultrahigh molecular weight polyethylene block.

And (3) placing the polyphenol surface modified ultra-high molecular weight polyethylene block into an aqueous solution containing a copper chloride compound (prepared by placing 1.0g of copper chloride into 50g of water), wherein the mass ratio of copper chloride to deionized water is 1:50, taking out after uniform oscillation for 22 hours at 30 ℃, washing with deionized water for 2 times, placing in deionized water for 30 minutes by ultrasonic treatment, and drying the surface of the block by nitrogen to obtain the copper ion antibacterial surface modified ultra-high molecular weight polyethylene block.

And characterizing the surface elements before and after modification of the ultra-high molecular weight polyethylene by an X-ray photoelectron spectrometer. Copper ions are not detected on the surface of the ultrahigh molecular weight polyethylene before modification, and the proportions of carbon, oxygen and copper on the surface of the ultrahigh molecular weight polyethylene sample modified by tannic acid and copper ions are 87.73%, 11.68% and 0.59%, which shows that the surface of the ultrahigh molecular weight polyethylene material after modification successfully modifies the copper ions.

And (3) performing antibacterial performance characterization on the surface of the ultra-high molecular weight polyethylene block by referring to the method of international standard ISO 22196. Staphylococcus aureus is selected as an experimental strain, and the antibacterial performance of the sample before and after modification is represented by a plate coating method. The total number of colonies of the unmodified ultra-high molecular weight polyethylene material is 22800cfu/cm2, and the total number of colonies of the copper ion modified ultra-high molecular weight polyethylene material is less than 20cfu/cm². According to the formula X4 ═ A-B/A]Calculating the bacteriostasis rate of the sample by 100%, wherein X4 is the bacteriostasis rate, A is the colony number of the control sample, and B is the colony number of the test sample. The surface bacteriostasis rate of the copper ion modified ultra-high molecular weight polyethylene material is more than 99.9 percent.

Example 2

And (1) sequentially carrying out ultrasonic treatment on the ultra-high molecular weight polyethylene block with the molecular weight of 100 ten thousand in deionized water and ethanol for 30 minutes at normal temperature to remove pollutants on the surface of the ultra-high molecular weight polyethylene block. And taking out the block after the ultrasonic treatment, and drying the surface of the block by using nitrogen to obtain a dry and clean ultrahigh molecular weight polyethylene block.

And (2) placing the ultra-high molecular weight polyethylene block (with the size of 60 mm x 20 mm x 2 mm) into a pH adjusting solution of tannic acid (prepared by placing 0.05g of tannic acid into 50mL of the pH adjusting solution), wherein the mass ratio of tannic acid to the pH adjusting solution in the tannic acid solution is 1:1000, the pH adjusting solution is a PBS (phosphate buffer solution) buffer solution, adjusting the pH value to 8.5, shaking at a constant speed for 5 hours at 20 ℃, taking out, washing with deionized water for 2 times, placing in the deionized water for 40 minutes by ultrasound, removing residual tannic acid molecules on the surface of the ultra-high molecular weight polyethylene, and drying the surface of the block by nitrogen to obtain the polyphenol surface modified ultra-high molecular weight polyethylene block.

And (3) placing the polyphenol surface modified ultra-high molecular weight polyethylene block into a copper nitrate aqueous solution (prepared by placing 0.5g of copper nitrate into 50g of water), wherein the mass ratio of copper nitrate to deionized water is 1:100, taking out after uniform oscillation for 48 hours at 60 ℃, washing for 2 times with deionized water, then placing the block into deionized water for ultrasonic treatment for 60 minutes, and drying the surface of the block with nitrogen to obtain the copper ion antibacterial surface modified ultra-high molecular weight polyethylene block.

Example 3

And (1) sequentially carrying out ultrasonic treatment on the ultra-high molecular weight polyethylene block with the molecular weight of 300 ten thousand in deionized water and ethanol for 50 minutes at normal temperature to remove pollutants on the surface of the ultra-high molecular weight polyethylene block. And taking out the block after the ultrasonic treatment, and drying the surface of the block by using nitrogen to obtain a dry and clean ultrahigh molecular weight polyethylene block.

And (2) placing the ultrahigh molecular weight polyethylene block (with the size of 60 mm 20 mm 2 mm) into a catechol pH adjusting solution (prepared by placing 0.2g of catechol into 50mL of the pH adjusting solution), wherein the mass ratio of the catechol in the catechol solution to the pH adjusting solution is 1:250, the pH adjusting solution is a boric acid-borax buffer solution, adjusting the pH value to 10, taking out after uniform oscillation at 70 ℃ for 6 hours, washing with deionized water for 2 times, placing in deionized water for 40 minutes by ultrasound, removing residual catechol molecules on the surface of the ultrahigh molecular weight polyethylene block, and drying the surface of the block by nitrogen to obtain the polyphenol surface modified ultrahigh molecular weight polyethylene block.

And (3) placing the polyphenol surface modified ultra-high molecular weight polyethylene block into a copper sulfate aqueous solution (prepared by placing 2g of copper sulfate into 50g of water), wherein the mass ratio of copper sulfate to deionized water is 1:25, taking out after uniform oscillation for 48 hours at 70 ℃, washing for 2 times by using the deionized water, then placing the block into the deionized water for ultrasonic treatment for 60 minutes, and drying the surface of the block by using nitrogen to obtain the copper ion antibacterial surface modified ultra-high molecular weight polyethylene block.

Example 4

And (1) sequentially carrying out ultrasonic treatment on the ultra-high molecular weight polyethylene block with the molecular weight of 400 ten thousand in deionized water and ethanol for 120 minutes at normal temperature to remove pollutants on the surface of the ultra-high molecular weight polyethylene block. And taking out the block after the ultrasonic treatment, and drying the surface of the block by using nitrogen to obtain a dry and clean ultrahigh molecular weight polyethylene block.

And (2) putting the ultra-high molecular weight polyethylene block (with the size of 60 mm x 20 mm x 2 mm) into a pH adjusting solution of pyrogalloc acid (prepared by putting 0.2g of pyrogalloc acid into 50mL of the pH adjusting solution), wherein the mass ratio of the pyrogalloc acid to the pH adjusting solution in the pyrogalloc acid solution is 1:250, the pH adjusting solution is sodium hydroxide solution, adjusting the pH value to 12, taking out after uniform oscillation at 50 ℃ for 10 hours, washing with deionized water for 2 times, then putting the solution into the deionized water for ultrasonic treatment for 40 minutes, removing pyrogalloc acid molecules remained on the surface of the ultra-high molecular weight polyethylene, and drying the surface of the block by using nitrogen to obtain the ultra-high molecular weight polyethylene block with the surface modified by polyphenol.

And (3) placing the polyphenol surface modified ultra-high molecular weight polyethylene block into a zinc chloride aqueous solution (prepared by placing 0.5g of zinc chloride into 50g of water), wherein the mass ratio of zinc chloride to deionized water is 1:100, taking out after uniform oscillation for 48 hours at 30 ℃, washing with deionized water for 2 times, then placing into deionized water for ultrasonic treatment for 60 minutes, and drying the surface of the block with nitrogen to obtain the zinc ion antibacterial surface modified ultra-high molecular weight polyethylene block.

Example 5

And (1) sequentially carrying out ultrasonic treatment on the ultra-high molecular weight polyethylene block with the molecular weight of 500 ten thousand in deionized water and ethanol for 50 minutes at normal temperature to remove pollutants on the surface of the ultra-high molecular weight polyethylene block. And taking out the block after the ultrasonic treatment, and drying the surface of the block by using nitrogen to obtain a dry and clean ultrahigh molecular weight polyethylene block.

And (2) placing the ultra-high molecular weight polyethylene block (with the size of 60 mm x 20 mm x 2 mm) into a positive adrenaline pH adjusting solution (prepared by placing 0.05g of positive adrenaline into 50mL of the pH adjusting solution), wherein the mass ratio of the positive adrenaline to the pH adjusting solution in the positive adrenaline solution is 1:100, the pH adjusting solution is a PBS buffer solution, adjusting the pH value to 9, taking out after uniform oscillation at 70 ℃ for 18 hours, washing with deionized water for 2 times, placing the solution into the deionized water for ultrasonic treatment for 40 minutes, removing the residual positive adrenaline molecules on the surface of the ultra-high molecular weight polyethylene, and drying the surface of the block with nitrogen to obtain the polyphenol surface modified ultra-high molecular weight polyethylene block.

And (3) placing the polyphenol surface modified ultra-high molecular weight polyethylene block into a zinc nitrate aqueous solution (prepared by placing 2g of zinc nitrate into 50g of water), wherein the mass ratio of zinc nitrate to deionized water is 1:25, taking out after uniform oscillation for 48 hours at 70 ℃, washing for 2 times with deionized water, then placing the block into deionized water for ultrasonic treatment for 60 minutes, and drying the surface of the block with nitrogen to obtain the zinc ion antibacterial surface modified ultra-high molecular weight polyethylene block.

Example 6

And (1) sequentially carrying out ultrasonic treatment on the ultra-high molecular weight polyethylene block with the molecular weight of 500 ten thousand in deionized water and ethanol for 50 minutes at normal temperature to remove pollutants on the surface of the ultra-high molecular weight polyethylene block. And taking out the block after the ultrasonic treatment, and drying the surface of the block by using nitrogen to obtain a dry and clean ultrahigh molecular weight polyethylene block.

And (2) placing the ultra-high molecular weight polyethylene block (with the size of 60 mm x 20 mm x 2 mm) into a dopamine pH adjusting solution (prepared by placing 0.1g of dopamine into 50mL of the pH adjusting solution), wherein the mass ratio of dopamine to the pH adjusting solution in the dopamine solution is 1:500, the pH adjusting solution is a potassium hydroxide solution, the pH value is adjusted to 12, the dopamine is taken out after being vibrated at 50 ℃ for 12 hours at a constant speed, the dopamine is washed for 2 times by deionized water and then placed into the deionized water for ultrasonic treatment for 40 minutes, the dopamine molecules remaining on the surface of the ultra-high molecular weight polyethylene block are removed, and the surface of the block is dried by nitrogen to obtain the polyphenol surface modified ultra-high molecular weight polyethylene block.

And (3) placing the polyphenol surface modified ultra-high molecular weight polyethylene block into a zinc sulfate aqueous solution (prepared by dissolving 0.5g of zinc sulfate in 50g of water), wherein the mass ratio of zinc sulfate to deionized water is 1:100, taking out after uniform oscillation at 70 ℃ for 48 hours, washing with deionized water for 2 times, then placing into deionized water, performing ultrasonic treatment for 60 minutes, and drying the surface of the block with nitrogen to obtain the zinc ion antibacterial surface modified ultra-high molecular weight polyethylene block.

Although the present application has been described with reference to a few embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the application as defined by the appended claims.