单颗粒自动化拉曼捕集分析

文档序号:835227 发布日期:2021-03-30 浏览:1次 >En<

阅读说明:本技术 单颗粒自动化拉曼捕集分析 (Single particle automated raman trapping analysis ) 是由 M·史蒂文斯 J·彭德斯 I·彭斯 于 2019-06-18 设计创作,主要内容包括:一种颗粒分析的自动化方法使用以下执行:电磁辐射源,所述电磁辐射源用于生成电磁辐射束;聚焦元件,所述聚焦元件用于将所述束引导到颗粒捕获区;检测器,所述检测器被配置成检测来自所述颗粒捕获区的信号响应;以及控制系统。将电磁辐射束聚焦到颗粒传送介质上,以限定用于将候选颗粒捕获在所述束内的所述颗粒捕获区。执行第一数据获取程序以对颗粒捕获进行测试。如果未检测到颗粒捕获,则重复所述第一数据获取程序。如果在所述束内检测到颗粒捕获,则执行第二数据获取程序以使用至少一种分析模态捕获颗粒数据,此后,将光束强度降低到子捕获水平,以从所述颗粒捕获区中释放所述颗粒。对所述颗粒传送介质中的连续颗粒重复步骤。(An automated method of particle analysis is performed using: an electromagnetic radiation source for generating a beam of electromagnetic radiation; a focusing element for directing the beam to a particle capture zone; a detector configured to detect a signal response from the particle capture zone; and a control system. Focusing a beam of electromagnetic radiation onto a particle transport medium to define the particle capture zone for capturing candidate particles within the beam. A first data acquisition procedure is performed to test for particle capture. If particle capture is not detected, the first data acquisition procedure is repeated. If particle capture is detected within the beam, a second data acquisition procedure is performed to capture particle data using at least one analysis modality, after which the beam intensity is reduced to a sub-capture level to release the particles from the particle capture zone. Repeating the steps for successive particles in the particle transport medium.)

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