阅读说明：本技术 基因测序仪 (Gene sequencer ) 是由 隋相坤 孙磊林 龙青山 于 2018-05-16 设计创作，主要内容包括：一种基因测序仪(10)包括基因测序芯片(11)、芯片平台(12)、密封与转接模块(13),芯片平台(12)包括芯片连接模块(122),密封与转接模块(13)包括弹性密封圈(131),弹性密封圈(131)包括本体(131a)及贯穿本体(131a)的通孔(131b),本体(131a)夹于基体(123)与基因测序芯片(11)之间,通孔(131b)连接于溶液入口(11a)与溶液流入通道(124)的出口或者连接于溶液出口(11b)与溶液流出通道(125)的入口之间。(The utility model provides a gene sequencer (10) is including gene sequencing chip (11), chip platform (12), sealed and switching module (13), chip platform (12) are including chip connection module (122), sealed and switching module (13) are including elasticity sealing washer (131), elasticity sealing washer (131) include body (131a) and through-hole (131b) that run through body (131a), body (131a) are pressed from both sides between base member (123) and gene sequencing chip (11), through-hole (131b) are connected in the export of solution entry (11a) and solution inflow channel (124) or are connected between the entry of solution export (11b) and solution outflow channel (125).)

A gene sequencer, comprising: the gene sequencer comprises a gene sequencing chip, a chip platform and a sealing and switching module,

the chip platform comprises a chip connecting module, the chip connecting module comprises a base body, a solution inflow channel and a solution outflow channel which are arranged on the base body,

the gene sequencing chip comprises a solution inlet, a solution outlet and an internal flow channel positioned between the solution inlet and the solution outlet,

the sealing and switching module is positioned between the outlet of the solution inflow channel and the solution inlet and between the solution outlet and the inlet of the solution outflow channel, and is used for leading the solution from the solution inflow channel into the gene sequencing chip and leading the sequenced solution out of the gene sequencing chip to the solution outflow channel,

the sealing and switching module comprises an elastic sealing ring, the elastic sealing ring comprises a body and a through hole penetrating through the body, the body is clamped between the base body and the gene sequencing chip, and the through hole is connected between the solution inlet and the outlet of the solution inflow channel or between the solution outlet and the inlet of the solution outflow channel.

The gene sequencer of claim 1, wherein: the body comprises a first end face corresponding to the gene sequencing chip and a second end face corresponding to the substrate of the chip connection module, the through hole penetrates through the first end face and the second end face, and the cross section of the first end face and/or the second end face is a three-dimensional annular face with a convex arc shape.

The gene sequencer of claim 1, wherein: the body comprises a first end face corresponding to the gene sequencing chip and a second end face corresponding to the substrate of the chip connection module, the through hole penetrates through the first end face and the second end face, and the first end face and/or the second end face are/is an inwards concave ring face which is concave towards the inside.

The gene sequencer of claim 3, wherein: the body includes first end, second end and connect in first end reaches connecting portion between the second end, first end with the diameter of second end is greater than the diameter of connecting portion, the through-hole runs through first end connecting portion reach the second end, first terminal surface is first end is close to the surface of gene sequencing chip, the second terminal surface is the second end is close to the surface of chip connection module's base member.

The gene sequencer of claim 4, wherein: the first end portion further comprises a first outer side face and a first bottom face, a chamfer is arranged between the first outer side face and the first end face, the first bottom face is connected to the first outer side face and the outer surface of the connecting portion, the second end portion further comprises a second outer side face and a second bottom face, the second outer side face and the second end face are provided with the chamfer, and the second bottom face is connected to the second outer side face and the outer surface of the connecting portion.

The gene sequencer of claim 1, wherein: the sealing and switching module further comprises a cover plate, the cover plate is clamped between the gene sequencing chip and the chip connecting module, the cover plate comprises a base plate and a first fixing hole penetrating through the base plate, and the first fixing hole is used for accommodating and fixing the elastic sealing ring.

The gene sequencer of claim 6, wherein: the cover plate further comprises a second fixing hole penetrating through the base plate, the chip connecting module further comprises a lock hole formed in the base body and corresponding to the second fixing hole, the sealing and switching module further comprises a locking piece, and the locking piece penetrates through the second fixing hole and is locked with the lock hole to fix the sealing and switching module on the chip connecting module.

The gene sequencer of claim 7, wherein: the number of the locking pieces and the number of the locking holes are at least two.

The gene sequencer of claim 7, wherein: the substrate comprises a first portion and a second portion connected with the first portion, the thickness of the first portion is larger than that of the second portion, the first fixing hole is formed in the first portion, and the second fixing hole is formed in the second portion and/or a connection position between the second portion and the first portion.

The gene sequencer of claim 9, wherein: the first portion comprises a first upper surface, a connecting surface connected with the second portion, and a first lower surface located on the opposite side of the first upper surface, the first lower surface further comprises a groove, at least part of one end, adjacent to the gene sequencing chip, of the elastic sealing ring is arranged on the first upper surface, and at least part of one end, adjacent to the chip connecting module, of the elastic sealing ring is accommodated in the groove.

The gene sequencer of claim 10, wherein: the second part comprises a second upper surface connected with the connecting surface and a second lower surface positioned on the opposite side of the second upper surface, and the first lower surface is at least partially flush with the second lower surface.

The gene sequencer of claim 11, wherein: the base body comprises a side wall, an upper bottom surface and a lower bottom surface, and the solution inflow channel or the solution outflow channel penetrates through the upper bottom surface and the lower bottom surface or penetrates through the upper bottom surface and the side wall.

The gene sequencer of claim 12, wherein: the predetermined area of the upper bottom surface is recessed towards one side of the lower bottom surface to form a recessed portion, and the lock hole and the solution inflow channel or the solution outflow channel are arranged in the recessed portion.

The gene sequencer of claim 1, wherein: the quantity of base member is two, corresponds on one of them base member the solution entry setting of gene sequencing chip just has solution inflow channel, and another base member corresponds the solution export setting of gene sequencing chip just has solution outflow channel, the quantity of elastic sealing ring is two sets of, and every group elastic sealing ring has at least one elastic sealing ring, and wherein the through-hole of a set of elastic sealing ring connect in solution entry with between the export of solution inflow channel, the through-hole of another set of elastic sealing ring connect in solution export with between the entry of solution outflow channel.

The gene sequencer of claim 14, wherein: each group of elastic sealing rings comprises a plurality of elastic sealing rings, the gene sequencing chip comprises a plurality of solution inlets and solution outlets which are in one-to-one correspondence with the elastic sealing rings, and the through hole of each elastic sealing ring is connected between one corresponding solution inlet and the outlet of one corresponding solution inflow channel or between one corresponding solution outlet and the inlet of one corresponding solution outflow channel.

The gene sequencer of claim 14, wherein: the chip platform comprises a carrying platform, and the two substrates are respectively positioned on two sides of the carrying platform.

The gene sequencer of claim 1, wherein: the elastic sealing ring is made of silica gel or rubber.

The gene sequencer of claim 1, wherein: the gene sequencing chip comprises a chip substrate, a top plate arranged on one side of the chip substrate, and an internal flow channel positioned on one side of the top plate close to the chip substrate, wherein the chip substrate is provided with a solution inlet and a solution outlet, and the top plate is covered on the chip substrate to ensure that the solution inlet is communicated with the solution outlet through the internal flow channel.