阅读说明：本技术 治疗痔疮的外用中药组合物及其制备方法 (External traditional Chinese medicine composition for treating haemorrhoids and preparation method thereof ) 是由 张银川 马红 于 2020-12-31 设计创作，主要内容包括：本发明涉及中药制剂领域,具体涉及一种治疗痔疮的外用中药组合物,由以下组分制备所得：朴硝20～30g,硼酸10～20g,白矾10～20g,乳香5～12g,没药5～12g,冰片1～5g。本发明具有消肿止痛,收敛止血,去腐生肌,燥湿止痒,活血散瘀的功效,可以使肛门括约肌松弛,改善局部血液循环,促使炎症消退,水肿消失。本发明适应症广泛,不论是炎性外痔、血栓性外痔、各期内痔、嵌顿痔、混合痔、肛裂、肛周感染、肛门瘙痒等肛肠疾病,还是痔手术后肌缘水肿、疼痛、出血、感染、脱出、潮湿等症状体征,均有明显疗效。(The invention relates to the field of traditional Chinese medicine preparations, in particular to an external traditional Chinese medicine composition for treating hemorrhoids, which is prepared from the following components: 20-30 g of mirabilite, 10-20 g of boric acid, 10-20 g of alum, 5-12 g of frankincense, 5-12 g of myrrh and 1-5 g of borneol. The invention has the effects of detumescence, pain relief, astringency, hemostasis, slough removal, granulation promotion, dampness elimination, itching relief, blood circulation promotion and blood stasis dissipation, can relax anal sphincter, improve local blood circulation, promote inflammation to subside and eliminate edema. The invention has wide adaptation diseases, and has obvious curative effects on anorectal diseases such as inflammatory external hemorrhoid, thrombotic external hemorrhoid, internal hemorrhoid at each stage, incarceration hemorrhoid, mixed hemorrhoid, anal fissure, perianal infection, anal itch and the like, and symptoms and signs such as muscle edge edema, pain, bleeding, infection, prolapse, dampness and the like after hemorrhoid operation.)

1. The external traditional Chinese medicine composition for treating the hemorrhoids is characterized in that: prepared from the following components: 20-30 g of mirabilite, 10-20 g of boric acid, 10-20 g of alum, 5-12 g of frankincense, 5-12 g of myrrh and 1-5 g of borneol.

2. The topical traditional Chinese medicine composition for treating hemorrhoids as claimed in claim 1, wherein: prepared from the following components: 20 g of mirabilite, 10 g of boric acid, 10 g of alum, 5 g of frankincense, 10 g of myrrh and 5 g of borneol.

3. A preparation method of an external traditional Chinese medicine composition for treating hemorrhoids is characterized by comprising the following steps: the method comprises the following steps:

s1, respectively drying Mirabilitum, boric acid, Alumen, Olibanum, Myrrha, and Borneolum Syntheticum, grinding into powder for 30min, and sequentially sieving with 50 mesh sieve, 80 mesh sieve, and 100 mesh sieve for the first time to obtain Chinese medicinal powder;

s2, mixing the obtained traditional Chinese medicine powder according to the proportion of any one of claims 1-2, uniformly stirring, bagging and sealing to obtain the traditional Chinese medicine powder.

Technical Field

The invention relates to the field of traditional Chinese medicine preparations, in particular to an external traditional Chinese medicine composition for treating hemorrhoids and a preparation method thereof.

Background

Hemorrhoids (hemorrhoids) are the most common anorectal diseases. The disease can occur at any age, but the incidence rate increases with age. The supporting structure of the anal pad, venous plexus and anastomotic artery branch are pathologically changed or displaced into internal hemorrhoids (internal hemorrhoidal). Pathological dilation or thrombosis of the distal subcutaneous venous plexus of the dentate line is external hemorrhoids (external hemorrhoids). The internal hemorrhoids are fused with each other to form mixed hemorrhoids (mixed hemorrhoidal hemorrhoids) through abundant anastomotic branches of venous plexus and external hemorrhoids at corresponding sites.

According to the investigation of fifty thousand population in some areas of China, the incidence rate of hemorrhoids reaches 46.26 percent, and in some areas, the incidence rate of hemorrhoids is 70 percent, and in European and American investigation and Japanese investigation, the incidence rate is 40 to 60 percent. Many patients have health and work affected by internal hemorrhoid prolapse, hematochezia and pain. Various researches have been continuously conducted on the causes and treatment methods of internal hemorrhoids, and there are many treatment methods, each of which has its advantages and disadvantages. At present, the internal hemorrhoids of stage III and mixed hemorrhoids are mainly treated by operation at home and abroad, the internal hemorrhoids of stage I and II are mainly treated by injection, and the ideal operation methods are circular excision (KIOS method and variant thereof), internal hemorrhoid excision (ligation) and external hemorrhoid excision open (MILIGAN method and variant thereof) and anastomat superior hemorrhoid mucosa circumcision (PPH). The application of several surgical methods has the advantages of complete excision of the focus and great complication and sequelae after the operation. Therefore, scholars at home and abroad always consider that the surgical treatment of the internal hemorrhoid and the mixed hemorrhoid in the III stage is not free from generating complications and sequelae. Specifically, the problems associated with post-operative surgery are roughly characterized by the following aspects: (1) postoperative pain (2) dyschezia (3) dyschezia (4) infectious edema (5) secondary bleeding (6) anal stenosis (7) anal relaxation (8) specific infection (tetanus) (9) delayed wound healing after operation, etc. Various problems after the comprehensive operation are caused by the operation, which is that the operation breaks the anatomical structure of the anorectal canal and damages the anorectal function. The ideal treatment method is a non-operative method, and A.W. Marino has a sentence of a name: those symptoms that do not have anal signs are not treated, nor are those anal signs that do not have symptoms. The treatment of hemorrhoids should therefore follow three principles: (1) asymptomatic hemorrhoids do not need to be treated; (2) symptomatic hemorrhoids are more severe than radical hemorrhoids and can relieve and eliminate symptoms; (3) the main is conservative treatment. In particular to a method which can ensure the curative effect and safety and has no side effect by selecting the basis of the specific physical signs and diseases of each patient. For patients without obvious anus signs and symptoms, complicated treatment or operation is not needed, namely even if the patients have obvious internal hemorrhoids and external hemorrhoids which can be detected, the patients do not have symptoms of bleeding, prolapse, pain and the like, and the patients do not need to be treated or injected by the operation. Generally, the treatment is conservative, and the treatment is ineffective or repeated for non-operative treatment, and the operative treatment is only adopted for the advanced hemorrhoidal disease with heavier symptoms.

At present, a plurality of methods and medicines for treating hemorrhoids are conservative at home and abroad, and each method has advantages and disadvantages, (1) although the hemorrhoids are treated by western medicines with certain curative effect, side effects of different degrees exist, and the recurrence rate is high. (2) The traditional Chinese medicine is taken orally and externally, has good safety, is not easy to relapse, has the general clinical cure rate of more than 55 percent and the effective rate of more than 95 percent. However, the traditional Chinese medicine for oral and external use needs to be decocted and washed orally and is inconvenient for modern people and difficult for some patients to insist on.

Disclosure of Invention

In order to solve the problems, the invention provides an external traditional Chinese medicine composition for treating internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure, postoperative swelling and pain and the like in each stage, which is simple and convenient to use, obvious in effect, safe and low in cost, and a preparation method thereof.

In order to achieve the purpose, the invention adopts the technical scheme that:

the externally applied traditional Chinese medicine composition for treating the hemorrhoids is prepared from the following components: 20-30 g of mirabilite, 10-20 g of boric acid, 10-20 g of alum, 5-12 g of frankincense, 5-12 g of myrrh and 1-5 g of borneol.

Preferably, the compound is prepared from the following components: 20 g of mirabilite, 10 g of boric acid, 10 g of alum, 5 g of frankincense, 10 g of myrrh and 5 g of borneol.

The invention also provides a preparation method of the external traditional Chinese medicine composition for treating hemorrhoids, which is characterized by comprising the following steps: the method comprises the following steps:

s1, respectively drying Mirabilitum, boric acid, Alumen, Olibanum, Myrrha, and Borneolum Syntheticum, grinding into powder for 30min, and sequentially sieving with 50 mesh sieve, 80 mesh sieve, and 100 mesh sieve for the first time to obtain Chinese medicinal powder;

s2, mixing the obtained Chinese medicinal powder in the above ratio, stirring, bagging, and sealing.

The method comprises the following steps: mirabilite: salty, bitter and cold in nature. It enters lung, stomach and large intestine meridians. It can relieve swelling and pain, and can be used for treating swelling and pain of hemorrhoid, and restlessness. Prescription of Chicken Peak Puji: 'Miao san' for treating hemorrhoid.

Alum: sour, astringent and cold in nature. Entering spleen, lung, stomach and large intestine channels, externally used for eliminating dampness and astringing, stopping bleeding and killing parasites, detoxifying and relieving pain, treating ulcer, washing rectocele, applying abscess and collecting water. Ben Cao Meng : it is indicated for internal hemorrhoid, proctoptosis, hematochezia and eczema. The main components of modern research comprise aluminum potassium sulfate and the like, and the external application has the effects of diminishing inflammation, astringing and preventing corrosion, and can coagulate protein, harden skin and stop bleeding.

Boric acid: sweet, salty and cool in nature, it enters lung and stomach meridians. Has effects in removing toxic materials, preventing putrefaction, clearing away heat, eliminating stagnation, and relieving swelling. The main component contains sodium tetraborate, and has astringent and protective effects on skin mucosa when being externally used.

Borneol: bitter taste and cold nature. It enters heart and liver meridians. Clear heat and remove toxicity, relieve swelling and alleviate pain. The tincture in vitro experiment of modern pharmacological research has inhibitory effect on Staphylococcus, Streptococcus, Diplococcus pneumoniae, Escherichia coli and some pathogenic dermatophytes.

Myrrh and frankincense: has effects of promoting blood circulation, relieving pain, eliminating swelling and promoting granulation, and can be used for treating hemorrhoid swelling.

The invention has the effects of detumescence, pain relief, astringency, hemostasis, slough removal, granulation promotion, dampness elimination, itching relief, blood circulation promotion and blood stasis dissipation, can relax anal sphincter, improve local blood circulation, promote inflammation to subside and eliminate edema. The invention has wide adaptation diseases, and has obvious curative effects on anorectal diseases such as inflammatory external hemorrhoid, thrombotic external hemorrhoid, internal hemorrhoid at each stage, incarceration hemorrhoid, mixed hemorrhoid, anal fissure, perianal infection, anal itch and the like, and symptoms and signs such as muscle edge edema, pain, bleeding, infection, prolapse, dampness and the like after hemorrhoid operation. The traditional Chinese medicine composition has the advantages of simple compatibility, low cost, safety, reliability, convenient use, obvious effect, no side effect and the like, is very tasty by patients with hemorrhoidal diseases, is one of the hot spots of the current anorectal diseases, particularly hemorrhoidal disease treatment, and has the clinical cure rate of about 58% and the total effective rate of about 95% after more than 960 cases of patients with hemorrhoidal diseases are applied and treated in nearly 5 years.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.

Example 1

Respectively drying Mirabilitum, boric acid, Alumen, Olibanum, Myrrha, and Borneolum, grinding in a grinder for half an hour, respectively sieving with 50 mesh sieve for the first time, 80 mesh sieve for the second time, and 100 mesh sieve for the third time to obtain Chinese medicinal powder;

weighing 20-30 g of mirabilite powder, 10-20 g of boric acid powder, 10-20 g of alum powder, 5-10 g of frankincense powder, 8-12 g of myrrh powder and 1-5 g of borneol powder, mixing, uniformly stirring, packaging into 1 bag, preparing 7 bags, placing 1 bag each time into a small basin, brewing with 1000ml of boiling water, fumigating and washing for 15-20 minutes, and 2 times a day. The ointment is applied to the anal margin of patients with perianal erosion after fumigation, one anus suppository is put into the anus, 7 days are a treatment course, the symptoms of the anus can be relieved or disappeared after most patients take the ointment for 3-5 days, and after 7 days, fumigation and washing can be changed once every night to continue to consolidate the treatment course.

Example 2

Respectively drying Mirabilitum, boric acid, Alumen, Olibanum, Myrrha, and Borneolum, grinding in a grinder for half an hour, respectively sieving with 50 mesh sieve for the first time, 80 mesh sieve for the second time, and 100 mesh sieve for the third time to obtain Chinese medicinal powder;

weighing 25 g of mirabilite powder, 15 g of boric acid powder, 15 g of alum powder, 5 g of frankincense powder, 10 g of myrrh powder and 5 g of borneol powder, mixing, uniformly stirring, filling into a sealed small plastic bag for 17 bags, wherein 1 bag is prepared each time, putting into a small basin, brewing with 1000ml of boiling water, fumigating and washing for 15-20 minutes, and 2 times a day. The ointment is applied to the anal margin of patients with perianal erosion after fumigation, one anus suppository is put into the anus, 7 days are a treatment course, the symptoms of the anus can be relieved or disappeared after most patients take the ointment for 3-5 days, and after 7 days, fumigation and washing can be changed once every night to continue to consolidate the treatment course. .

Clinical data

1. Collecting data: selecting the history, disease condition, age, sex and original treatment method. 496 cases of the group were male and 464 cases; the age is 13-75 years, and the course of disease is 3 months to 30 years. 324 cases of mixed hemorrhoid inflammatory edema, 56 cases of varicose mixed hemorrhoid, 152 cases of inflammatory external hemorrhoid, 35 cases of internal hemorrhoid prolapse incarceration, 165 cases of internal hemorrhoid prolapse edema, 72 cases of internal hemorrhoid hematochezia and 32 cases of thrombotic external hemorrhoid. Postoperative muscle margin edema in 68 cases and anal fissure in 56 cases.

2. The usage and dosage are as follows: 30 g of mirabilite, 15 g of sail, and 15 g of boric acid; frankincense 5 g, myrrh 10 g and borneol 5 g. Finally, mix the last medicine evenly, divide into 1 bag, each time 1 bag, put into the basin, soak with 1000ml of boiling water, smoke first and wash for 15-20 minutes, 2 times a day. After patients with perianal erosion are fumigated and washed, the anus edge is coated with the Meibao moist burn cream, one piece of the anus suppository is put into the anus, and 7 days is a treatment course. Most patients can relieve or disappear after taking the medicine for 3-5 days, and the patients can be fumigated and washed once every night after 7 days, and a treatment course is continuously consolidated.

3. And (3) analyzing the curative effect: most patients can relieve or disappear the symptoms of the anus after taking the medicine for 3-5 days, and the maximum time is 7 days. The fumigation and washing can be carried out once every night, and the consolidation treatment is continued for a treatment course. After one course of treatment, 564 (58.75)% of 960 patients are cured, 355 (36.98)% of improved patients is not effective, 41 (4.27)% of total effective rate is 95.73%. 160 patients are followed up one year later, 19 patients (11.87)%, and the patients with relapse are mostly caused by drinking or eating spicy.

4. Adverse reactions: after the individual patient takes the medicine, the local anus is dry and uncomfortable, and the external application of the Meibao moist burn cream can disappear.

5. Note that: (1) the invention is a local fumigation lotion, which is only externally used and can not be orally taken. After a treatment course, no obvious effect is seen, and other methods can be adopted. (2) During the treatment period, the patient is advised to 'fatigue less, angry abstinence, far-reaching and dietetic restraint'. (3) After the acne falls out during fumigation, the acne is sent back to the anus by hands in time, and if the hand support cannot return, the acne is sent to a hospital in time for treatment. (4) At ordinary times, the exercise is strengthened, the diet is regular, the food of spicy food is avoided, the constipation is prevented, and the local sanitation of the anus is kept.

The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.