阅读说明：本技术 治疗中、重度痤疮的外用中药组和物及含该外用中药组合物的面膜 (External traditional Chinese medicine and composition for treating moderate and severe acne and mask containing external traditional Chinese medicine composition ) 是由 李丽 于 2021-07-27 设计创作，主要内容包括：一种治疗中、重度痤疮的外用中药组和物及含该外用中药组合物的面膜,属于中药技术领域。所述外用中药组合物主要由下列重量份数的原料药组成：蒲公英10～30份,连翘10～30份,紫草4～12份,牡丹皮4～12份,浙贝母4～12份,天花粉4～12份,皂角刺5～15份,苦参3～10份,白鲜皮5～15份,丹参6～20份,石菖蒲5～15份,乳香3～10份,没药3～10份,生薏苡仁10～30份,麻黄4～12份,杏仁5～15份,白芷4～12份,甘草3～10份,该外用中药组合物配伍科学合理,功效稳定,有清热解毒、消肿散结、活血凉血、除湿杀虫、疗疮生肌、润肤美白等功效,同时可改善痤疮皮脂溢出、面部暗沉的问题,本发明的面膜使用安全、携带方便,临床总有效率达90%。(An external traditional Chinese medicine composition for treating moderate and severe acne and a mask containing the external traditional Chinese medicine composition belong to the technical field of traditional Chinese medicines. The external traditional Chinese medicine composition mainly comprises the following raw material medicines in parts by weight: 10-30 parts of dandelion, 10-30 parts of fructus forsythiae, 4-12 parts of lithospermum, 4-12 parts of moutan bark, 4-12 parts of thunberg fritillary bulb, 4-12 parts of trichosanthes root, 5-15 parts of spina gleditsiae, 3-10 parts of radix sophorae flavescentis, 5-15 parts of cortex dictamni, 6-20 parts of salvia miltiorrhiza, 5-15 parts of rhizoma acori graminei, 3-10 parts of frankincense, 3-10 parts of myrrh, 10-30 parts of raw coix seed, 4-12 parts of ephedra, 5-15 parts of almond, 4-12 parts of radix angelicae and 3-10 parts of liquorice.)

1. An external traditional Chinese medicine composition for treating moderate and severe acne is characterized in that: the traditional Chinese medicine composition mainly comprises the following raw material medicines in parts by weight: 10-30 parts of dandelion, 10-30 parts of fructus forsythiae, 4-12 parts of lithospermum, 4-12 parts of moutan bark, 4-12 parts of thunberg fritillary bulb, 4-12 parts of trichosanthes root, 5-15 parts of spina gleditsiae, 3-10 parts of radix sophorae flavescentis, 5-15 parts of cortex dictamni, 6-20 parts of salvia miltiorrhiza, 5-15 parts of rhizoma acori graminei, 3-10 parts of frankincense, 3-10 parts of myrrh, 10-30 parts of raw coix seed, 4-12 parts of ephedra, 5-15 parts of almond, 4-12 parts of radix angelicae and 3-10 parts of liquorice.

2. A topical traditional Chinese medicine and composition for the treatment of moderate to severe acne as claimed in claim 1 wherein: the traditional Chinese medicine composition mainly comprises, by weight, 30 parts of dandelion, 30 parts of fructus forsythiae, 12 parts of lithospermum, 12 parts of moutan bark, 12 parts of thunberg fritillary bulb, 12 parts of trichosanthes root, 15 parts of spina gleditsiae, 10 parts of radix sophorae flavescentis, 15 parts of cortex dictamni, 20 parts of salvia miltiorrhiza, 15 parts of rhizoma acori graminei, 10 parts of frankincense, 10 parts of myrrh, 30 parts of raw coix seed, 12 parts of ephedra, 15 parts of almond, 12 parts of radix angelicae and 10 parts of liquorice.

3. A mask, characterized in that: the facial mask consists of the external traditional Chinese medicine composition for treating moderate and severe acne and excipient according to claim 1 or 2.

4. The mask of claim 3, wherein: the excipient is any one of green tea water, calamine lotion or fermented glutinous rice juice.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external traditional Chinese medicine composition for treating moderate and severe acne and a mask containing the external traditional Chinese medicine composition.

Background

Acne is an inflammatory disease of the pilosebaceous unit which is clinically common in dermatology, and data of a global disease burden study in 2013 show that acne accounts for 0.29% of all skin diseases and 1.79% of the global disease burden. Acne has various damages such as acne, pimple, pustule, nodule, cyst and scar, is usually caused on face, chest and back, is frequently caused in adolescent men and women, is often accompanied with sebum overflow, has the characteristics of high morbidity, easy recurrence, difficult radical cure and the like, and also has certain damage tolerance.

There are western and chinese treatments for acne at present. From the perspective of western medicine, the pathogenesis of acne is not completely clarified, the pathogenesis factors and pathogenesis are extremely complex, the common action of multiple factors causes the occurrence and development of acne, and western medicines used in acne treatment guidelines of various countries are different in large and small. The main means of western medicines for treating acne are antibiotics, tretinoin and derivatives thereof, anti-androgen medicines and the like, and have the defects of large side effect, single effect, more contraindications and the like. The traditional Chinese medicine treatment is relatively mild, high in safety, good in curative effect and low in recurrence rate due to the treatment of people.

Although the curative effect of the traditional Chinese medicine for treating acne by oral administration can be confirmed, most of the traditional Chinese medicine has the problems of slow effect, long treatment course and poor patient compliance, and some oral medicines have certain curative effect on acne diseases, but some medicines in the formula are hot and dry and have stronger effect, such as dragon's blood, have larger effect of promoting blood circulation, and are not suitable for pregnant women and women during menstruation; cicada slough can cause anaphylactic reaction and the like after being taken, so that medicinal components of the medicament are not good in compatibility and unstable in effect, and the treatment effect is influenced.

Disclosure of Invention

In view of the above, the invention provides an external traditional Chinese medicine composition for treating moderate and severe acne and a mask containing the external traditional Chinese medicine composition.

The technical scheme adopted by the invention for solving the technical problems is as follows:

an external traditional Chinese medicine composition for treating moderate and severe acne is mainly prepared from the following raw material medicines in parts by weight: 10-30 parts of dandelion, 10-30 parts of fructus forsythiae, 4-12 parts of lithospermum, 4-12 parts of moutan bark, 4-12 parts of thunberg fritillary bulb, 4-12 parts of trichosanthes root, 5-15 parts of spina gleditsiae, 3-10 parts of radix sophorae flavescentis, 5-15 parts of cortex dictamni, 6-20 parts of salvia miltiorrhiza, 5-15 parts of rhizoma acori graminei, 3-10 parts of frankincense, 3-10 parts of myrrh, 10-30 parts of raw coix seed, 4-12 parts of ephedra, 5-15 parts of almond, 4-12 parts of radix angelicae and 3-10 parts of liquorice.

Preferably, the external traditional Chinese medicine and the composition for treating moderate and severe acne mainly comprise, by weight, 30 parts of dandelion, 30 parts of fructus forsythiae, 12 parts of lithospermum, 12 parts of moutan bark, 12 parts of thunberg fritillary bulb, 12 parts of trichosanthes root, 15 parts of spina gleditsiae, 10 parts of radix sophorae flavescentis, 15 parts of cortex dictamni, 20 parts of salvia miltiorrhiza, 15 parts of rhizoma acori graminei, 10 parts of frankincense, 10 parts of myrrh, 30 parts of raw coix seed, 12 parts of ephedra, 15 parts of almond, 12 parts of radix angelicae and 10 parts of liquorice.

The invention also provides a facial mask which consists of the external traditional Chinese medicine and the composition for treating moderate and severe acne and an excipient.

Preferably, the excipient is any one of green tea water, calamine lotion and fermented glutinous rice juice.

The external traditional Chinese medicine and the external traditional Chinese medicine composition for treating moderate and severe acne are created by the inventor according to the principle of externally applying the medicine based on syndrome differentiation of traditional Chinese medicine aiming at the pathogenesis characteristics of acne, are used for observing the curative effect of the external traditional Chinese medicine in 4 years of clinical practice, and have the following pharmacological actions of all the raw materials of the external traditional Chinese medicine composition:

dandelion: sweet, bitter and cold in nature. Enter spleen, stomach and kidney meridians, clear heat and remove toxicity, cure abscess and dissipate nodulation.

Fructus forsythiae: bitter taste and cool nature. Entering heart, liver and gallbladder meridians, clearing heat and removing toxicity, relieving swelling and dissipating nodulation, dispelling wind and heat, entering heart meridian with bitter cold, it can clear heart fire, relieve sore toxicity, and resolve carbuncle, swelling and accumulation, so it is called "Chu Jia Sheng Yao".

Lithospermum: bitter taste and cold nature. Enter the pericardium and liver meridians. Cool blood, activate blood, clear heat and remove toxicity.

Moutan bark: bitter and pungent in flavor and slightly cold in nature. Enter heart, liver and kidney meridians. Clear heat and cool blood, activate blood and dissipate blood stasis.

Thunberg fritillary bulb: it is cold in nature and bitter in taste, and has the effects of clearing lung heat, clearing and resolving heat phlegm, removing toxic substance, resolving hard mass and resolving carbuncle.

Trichosanthes root: sweet, slightly bitter and slightly cold in nature. It enters lung and stomach meridians. Clear heat and purge fire, resolve swelling and expel pus. It can clear heat and purge fire to remove toxicity, and resolve swelling and discharge pus to treat sore, and is indicated for early stage of sore and abscess with excessive heat-toxicity and pus formation before it can resolve the sore and discharge pus.

Spina gleditsiae: pungent taste and warm nature. Enter liver and kidney meridians. Has effects in relieving swelling, expelling pus, removing toxic materials, expelling pathogenic wind, and killing parasite. Pungent flavor can disperse, move qi and blood, soften hardness and dissipate nodulation, warm property can dispel wind, activate blood and resolve stasis.

Flavescent sophora root: bitter taste and cold nature. It enters heart, liver, stomach, large intestine and bladder meridians. Has the effects of clearing heat, drying dampness, killing parasites and relieving itching.

And (3) preparing cortex dictamni: bitter, salty and cold in nature. Enter spleen, lung, small intestine, stomach and bladder meridians. Can clear heat and dry dampness; dispelling wind and relieving itching; and (5) detoxifying. Can be used for treating dermatoses due to wind-heat and dampness.

Red sage root: bitter and slightly cold in taste. Enter heart and liver meridians. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle.

Grassleaf sweelflag rhizome: pungent and bitter with warm nature. It enters heart, liver and stomach meridians. It can resolve dampness, induce resuscitation and eliminate phlegm. It is externally used for eliminating dampness, killing parasites, healing sore, relieving itching, dispelling wind and relieving swelling.

Frankincense: being bitter and pungent with the actions of purging and dispersing, it can warm and unblock and enter heart, liver and spleen meridians. So it can dredge the channels and collaterals, activate blood and remove stasis, and activate blood stasis and remove stasis to relieve pain, swelling and pain, and promote muscle growth, so it has the actions of alleviating pain, detumescence and promoting granulation.

Myrrh: pungent and bitter in flavor and mild in nature. Enter heart, liver and spleen meridians. Dispel blood stasis, activate blood and stop bleeding, resolve swelling and promote tissue regeneration.

Herba ephedrae: pungent, slightly bitter and warm in nature. Enter lung meridian and bladder meridian. The Ephedra, herba Ephedrae has the effects of dispelling cold, opening the striae, opening the wei-defensive qi to break mass and accumulation, and it is from Shen nong Ben Cao Jing that it can warm and dredge yang qi, and qi and blood stasis, and open the striae, congealing cold and relieving, and qi and blood circulation, and toxicity can be eliminated accordingly.

Almond: bitter taste and slightly warm nature. It enters lung and large intestine meridians. For wind dryness, it moistens skin, and kills parasites to treat sores and scabies. Ancient Almond in the family of pyocutaneous disease skin is usually externally used for dispelling wind, moistening dryness and killing parasites. So it can dispel pathogenic wind from the skin surface and moisten the hair orifices. In general, when there is an initial carbuncle, deep-rooted carbuncle and pyogenic infections, it is used to dispel qi and eliminate internally, moisten hair and orifices and promote tissue regeneration.

Coix seed: sweet and bland in flavor and cool in nature. Raw Job's tears seed is cool in nature, can dry soil, clear gold, induce diuresis, purge dampness, clear heat, expel pus, detoxify and dissipate nodulation.

Radix angelicae: pungent flavor and warm nature. Enter lung and stomach meridians. Dispel wind and cold, unblock orifices and alleviate pain, relieve swelling and expel pus, dry dampness and stop leucorrhea. Radix Angelicae Dahuricae, being pungent and warm and fragrant, can dispel wind and cold, direct the head and eyes to clear orifices, also can dry dampness and raise yang, reaches the skin externally, and promotes the interior to clear qi. Pungent-warm property can dissipate nodulation directly to the affected part, enter lung and spleen and treat ulcer, erosion, pus discharge and flesh growth. It is warm in nature and thick in qi, and is the main herb of yangming, and abscess and deep-rooted carbuncle are damp-heat of yangming, so the efficacy of expelling pus and promoting tissue regeneration cannot be underestimated. Although the root of Dahurian angelica is listed as the exterior-releasing agent, it should not be regarded as the exterior-releasing agent, but also has the functions of "encouraging middle-jiao yang and ascending, clearing and lifting qi and sinking", the "obstruction of yang qi" is the common pathogenesis of exterior syndrome and disorder of spleen and stomach, and the smooth arrival of yang qi is the common transformation mechanism. Radix Angelicae Dahuricae can promote the health of Ying and Wei and spleen and heal acne.

Licorice root: sweet and mild in taste. Enter heart, spleen, lung and stomach meridians. Unprocessed is cool, and can clear heat and remove toxicity, dispel wind and relieve itching, and harmonize property of the medicine. It is suitable for eliminating toxic swelling.

Modern pharmacological studies have shown that: herba Taraxaci is used for treating various infectious and suppurative diseases, and has antibacterial effect. Fructus forsythiae has antibacterial and antiviral effects, and has inhibitory effect on various bacteria. Radix Arnebiae has antibacterial and antiinflammatory effects, and can inhibit various bacteria. Cortex moutan has antiallergic, antibacterial, anthelmintic, and skin caring effects. The cortex dictamni has different degrees of inhibition effects on various pathogenic fungi. Total tanshinone in Saviae Miltiorrhizae radix has effects of inhibiting Staphylococcus aureus and its drug-resistant strain, and promoting wound healing. The rhizoma acori graminei can inhibit bacteria for external use, and the high-concentration rhizoma acori graminei leaching solution has the effect of inhibiting common pathogenic fungi of skin. The frankincense extract and the monomeric compound thereof have good effects of resisting inflammation, ulcer and fibrosis and promoting wound healing. Herba Ephedrae extract has antiviral, anti-wrinkle, and skin elasticity maintaining effects; the herba Ephedrae polysaccharide has antioxidant effect; the water extract and ethanol extract of herba Ephedrae have antiallergic effect. The coix seed has the effects of moistening skin, whitening skin and removing freckles by external application, can smooth, moisten and whiten skin, and can eliminate acne, mottle, flat wart and the like, thereby being the essential medicine for treating facial flat wart, chloasma and acne. The angelica dahurica has the effect of resisting pathogenic microorganisms, the angelica dahurica tincture has the obvious effect of inhibiting dinitrochlorobenzene allergic contact dermatitis, the sensitivity of skin to UVA can be reduced, the angelica dahurica tincture can improve the sensitivity of skin to PUVA and strengthen the effect of ultraviolet rays, and the angelica dahurica is externally used as a cosmetic essential medicine. The liquorice can enhance the disease resistance of skin by external application, is anti-inflammatory, can effectively prevent allergy, improves adverse reactions of cosmetics and other external factors to the skin, can control the activation of the neuraminidase, avoids more melanin, and has the whitening effect.

In the external traditional Chinese medicine and the composition for treating moderate and severe acne provided by the invention, the dandelion and the forsythia suspense are used together to clear away heat and toxic materials, reduce swelling and dissipate stagnation, and are monarch medicines; the lithospermum, the moutan bark, the thunberg fritillary bulb and the trichosanthes root are used as ministerial drugs for clearing heat and removing toxicity, cooling blood and activating blood, and reducing swelling and resolving masses, and the monarch drugs are used for strengthening the effects of clearing heat and removing toxicity, and have the effects of cooling blood, reducing swelling and resolving masses; the radix sophorae flavescentis and the cortex dictamni strengthen the effects of clearing heat and removing toxicity of monarch drugs and ministerial drugs, have the effects of dispelling wind, eliminating dampness and killing insects and are adjuvant drugs; spina Gleditsiae, Saviae Miltiorrhizae radix, Olibanum, and Myrrha enhance the effects of promoting blood circulation, relieving swelling, and resolving hard mass of principal and ministerial drugs, and are adjuvant drugs, wherein Olibanum and Myrrha also have the effects of treating sore and promoting granulation, and can inhibit scar formation of acne patients; the grassleaf sweelflag rhizome and the raw coix seed not only help monarch drugs and ministerial drugs to reduce swelling and heal wound, but also can clear heat, eliminate dampness and kill parasites, play a role in treating concurrent symptoms and are adjuvant drugs; in addition, the grassleaf sweelflag rhizome, the raw coix seed, the dahurian angelica root and the bitter apricot seed have the functions of drying dampness, whitening and moisturizing the skin, improving the dull and greasy face of patients with acne and are used as adjuvant drugs; ma xing Yi ren gan Tang (herba Ephedrae, radix Coicis semen, semen Armeniacae amarum, and Glycyrrhrizae radix) as guiding drug has effects of opening skin and hair, benefiting lung qi, invigorating spleen soil, and guiding pathogen out, and Glycyrrhrizae radix has effects of clearing heat and detoxicating, and harmonizing the effects of the above drugs.

According to the technical scheme, the invention provides an external traditional Chinese medicine and a composition for treating moderate and severe acne and a mask containing the external traditional Chinese medicine composition, and compared with the prior art, the external traditional Chinese medicine and the composition have the following beneficial effects: according to the traditional Chinese medicine theory of dialectical treatment, the external traditional Chinese medicine composition is subjected to traditional Chinese medicine formula screening aiming at the main pathogenesis characteristics of acne, is reasonable in compatibility and stable in effect, and the medicines are cooperated to play the effects of clearing heat and removing toxicity, eliminating swelling and resolving masses, activating blood and cooling blood, removing dampness and killing insects, treating sores and promoting tissue regeneration, moistening skin and whitening and the like, can improve the problems of seborrhea of acne and dark face, and is particularly suitable for treating moderate and severe acne with skin lesions mainly comprising pustules, nodules and cysts; the mask provided by the invention has the characteristics of safe use, convenient carrying and the like, can be directly acted on a pathological change part, has the clinical total effective rate of 90 percent, and is convenient for clinical application and popularization.

Detailed Description

The technical solution and the technical effect of the present invention will be further described in detail with reference to the following embodiments of the present invention.

The invention provides an external traditional Chinese medicine and a composition for treating moderate and severe acne, which mainly comprise the following raw material medicines in parts by weight: 10-30 parts of dandelion, 10-30 parts of fructus forsythiae, 4-12 parts of lithospermum, 4-12 parts of moutan bark, 4-12 parts of thunberg fritillary bulb, 4-12 parts of trichosanthes root, 5-15 parts of spina gleditsiae, 3-10 parts of radix sophorae flavescentis, 5-15 parts of cortex dictamni, 6-20 parts of salvia miltiorrhiza, 5-15 parts of rhizoma acori graminei, 3-10 parts of frankincense, 3-10 parts of myrrh, 10-30 parts of raw coix seed, 4-12 parts of ephedra, 5-15 parts of almond, 4-12 parts of radix angelicae and 3-10 parts of liquorice.

Further, the external traditional Chinese medicine composition for treating moderate and severe acne mainly comprises the following raw material medicines in parts by weight: 30 parts of dandelion, 30 parts of fructus forsythiae, 12 parts of lithospermum, 12 parts of moutan bark, 12 parts of thunberg fritillary bulb, 12 parts of trichosanthes root, 15 parts of spina gleditsiae, 10 parts of radix sophorae flavescentis, 15 parts of cortex dictamni, 20 parts of salvia miltiorrhiza, 15 parts of rhizoma acori graminei, 10 parts of frankincense, 10 parts of myrrh, 30 parts of raw coix seed, 12 parts of ephedra, 15 parts of almond, 12 parts of radix angelicae and 10 parts of liquorice.

The invention also provides a facial mask which consists of the external traditional Chinese medicine and the composition for treating moderate and severe acne and an excipient.

Further, the excipient is any one of green tea water, calamine lotion or fermented glutinous rice juice. Fermented glutinous rice juice: activating meridians, dredging collaterals, whitening skin, promoting blood circulation, thickening intestines and stomach, moistening skin, dissipating dampness, improving local blood circulation, nourishing skin tissue, and relieving dryness and itching. Green tea water: with a cool nature, it has the actions of clearing heat, resolving phlegm, removing toxicity and removing dampness. The calamine lotion has the effects of detoxifying, astringing dampness, relieving itching and healing sore, can partially absorb secretion of wound surface, and has the effects of astringing and protecting.

The preparation method of the mask comprises the following steps: weighing 30 parts of dandelion, 30 parts of fructus forsythiae, 12 parts of lithospermum, 12 parts of moutan bark, 12 parts of thunberg fritillary bulb, 12 parts of trichosanthes root, 15 parts of spina gleditsiae, 10 parts of radix sophorae flavescentis, 15 parts of cortex dictamni, 20 parts of salvia miltiorrhiza, 15 parts of rhizoma acori graminei, 10 parts of frankincense, 10 parts of myrrh, 30 parts of raw coix seed, 12 parts of ephedra, 15 parts of almond, 12 parts of radix angelicae and 10 parts of liquorice by weight, crushing the raw materials of the traditional Chinese medicine decoction pieces, sieving the crushed raw materials by a 200-mesh sieve, and mixing the crushed raw materials with 10-20 mL of excipient (according to the convenience of an operator, the excipient is any one of fermented glutinous rice juice, green tea water and calamine lotion) to form the mask. The application method of the mask comprises the following steps: the facial mask is applied to the skin except eyes and mouth, and covered with Gypsum Fibrosum thermal inversion film to promote drug absorption. The preparation is administered 1-2 times per week for one week as a treatment course.

The preparation method of the mask comprises the following steps: weighing 30 parts of dandelion, 30 parts of fructus forsythiae, 12 parts of lithospermum, 12 parts of moutan bark, 12 parts of thunberg fritillary bulb, 12 parts of trichosanthes root, 15 parts of spina gleditsiae, 10 parts of radix sophorae flavescentis, 15 parts of cortex dictamni, 20 parts of salvia miltiorrhiza, 15 parts of rhizoma acori graminei, 10 parts of frankincense, 10 parts of myrrh, 30 parts of raw coix seed, 12 parts of ephedra, 15 parts of almond, 12 parts of radix angelicae and 10 parts of liquorice by weight, grinding the raw materials of the traditional Chinese medicine granules into superfine powder, and mixing the superfine powder with 10-20 mL of excipient (according to the convenience of an operator, the excipient is any one of fermented glutinous rice juice, green tea water and calamine lotion) to form the mask uniformly. The application method of the mask comprises the following steps: the facial mask is applied to the skin except eyes and mouth, and covered with Gypsum Fibrosum thermal inversion film to promote drug absorption. The preparation is administered 1-2 times per week for one week as a treatment course.

The clinical tests of the external traditional Chinese medicine composition for treating moderate and severe acne provided by the invention are as follows:

1.1 general data

The treatment group is selected from 56 outpatient clinic use patients in 2018, the age is 15-38 years, 22 men and 34 women; the control group adopts 80 cases of personalized dialectical oral traditional Chinese medicine treatment for comparison, 38 cases of men and 42 cases of women. The product has no difference in age and is comparable.

1.2 test methods

The treatment group externally uses the facial mask for treating moderate and severe acne prepared by the embodiment of the invention, the facial mask is applied to the facial skin except eyes and mouths, and a plaster hot-rolled film is covered on the facial mask to promote the drug absorption. The treatment course is 1-2 times per week, one week, and acne removing operation can be performed before operation, so as to improve curative effect and shorten treatment course.

The control group adopts personalized oral Chinese medicinal composition with syndrome differentiation, 2-3 times per day, and one week is a treatment course.

1.3 diagnostic criteria

The onset of disease in adolescence is well at the developed parts of sebaceous glands in the face, upper chest and back, and is distributed symmetrically. The skin lesions are follicular papules, pustules, nodules, cysts, comedones and scars with seborrhea and chronic transit.

1.4 symptom Scoring criteria

Before treatment, the number, the form and the position of the acne lesions of the patient are carefully counted and recorded.

1 pimple: score 1.

1 acne: score 1.

1 pustule: score 2.

1 node: the diameter is less than or equal to 0.5cm, and the score is 3; the diameter is more than 0.5cm and less than or equal to 1cm, and the score is 5; diameter > lcm, score 7.

1 cyst: the diameter is less than or equal to 1cm, and the score is 8 points; the diameter is more than lcm and less than or equal to 1.5cm, and the score is 10 points; diameter > 1.5cm, score 12.

1.5 methods of treatment

The outpatient treatment patient mixes the traditional Chinese medicine composition of the invention with excipient uniformly to prepare a facial mask, applies the facial mask on the affected part, then prepares a gypsum hot pouring film to cover the traditional Chinese medicine facial mask, removes the gypsum hot pouring film after 20 minutes, cleans the traditional Chinese medicine facial mask with clear water, 1-2 times per week, and one week is a treatment course for 4-12 treatment courses.

1.6 therapeutic efficacy criteria

And (3) healing: the integral reduction of old skin loss is more than or equal to 95 percent; no new skin loss;

the effect is shown: the integral reduction of old skin loss is more than or equal to 70 percent;

improvement: the integral reduction of old skin loss is more than or equal to 30 percent;

and (4) invalidation: the old skin loss integral decreased by < 30%.

Total effective rate = (number of cure cases + number of significant cases)/total number of cases × 100%.

1.7 results

TABLE 1 comparison of clinical efficacy of the treatment and control groups

Group of	Number of examples	Recovery method	Show effect	Improvement of life	Invalidation	Total effective rate (%)
							Treatment group	56	22	15	13	5	90
Control group	80	28	32	0	20	75

As can be seen from Table 1, in 56 patients in the treatment group, 22 patients are cured, 15 patients are obviously effective, 13 patients are improved, 5 patients are ineffective, and the total effective rate reaches 90%. In 80 cases of the control group personalized syndrome differentiation oral traditional Chinese medicines, 28 cases are cured, 32 cases are obviously effective, 20 cases are ineffective, and the total effective rate is 75%. Compared with the oral traditional Chinese medicine control group, the external traditional Chinese medicine composition for the treatment group can directly act on the affected part, and the curative effect is superior to that of the oral traditional Chinese medicine. The treatment group basically does not need to use personalized medicine based on syndrome differentiation of traditional Chinese medicine, the operation is simple and convenient, the effect is fast, no obvious adverse reaction exists, and the patient is more easily accepted. The oral administration of the traditional Chinese medicine is abandoned after 2-3 courses of treatment in the ineffective cases, and the analysis reasons are as follows: 1. the traditional Chinese medicine has the disadvantages of improper medication and poor curative effect by personalized syndrome differentiation; 2. the oral medicine has slow effect on treating the acne and poor patient compliance; 3. it is inconvenient to carry. In the treatment groups, the compatibility of the components and the compatibility of the external medicines are mainly characterized, the traditional Chinese medicine is mainly used for treating moderate and severe acne through external application, most of the medicines are bitter and cold, heat-clearing and detoxifying, and blood cooling and stagnation dissipating products which are mainly pungent and warm in nature, the main purpose is to attack evil and treat symptoms, most of clinical acne patients are weak in spleen and stomach, and the symptoms are mainly of deficiency and excess, and if the traditional Chinese medicine is taken for a long time, the traditional Chinese medicine is easy to break qi, consume qi and damage yang qi.

1.8 typical cases

In order to confirm the remarkable curative effect of the external traditional Chinese medicine composition, the past medical record is randomly extracted as follows:

case 1

Wu, female, 26 years old, visited the disease in 2018, 5 months, with "repeat eruption of the face for 2 years", and patients complain of many medical institutions for facial skin rash to see the disease with little curative effect. Physical examination: the face is mainly acne on the forehead and cheeks on both sides, red pimple and pustule, a few cysts and nodules, greasy face and dark skin color. And (3) diagnosis: acne, the acne skin rash of the analyzed patient is characterized by papule and pustule types, and belongs to moderate and light types. After the treatment, the acne removing operation is performed on the face of a patient, then the external traditional Chinese medicine composition is used, green tea water is mixed into a slightly thick facial mask, the facial mask is smeared to cover the facial area except the mouth, the nose and the eyes, the gypsum hot-melt film is removed after 30 minutes of application, and the face is cleaned. 1 week for 1 treatment course, and 1 week for 1 treatment course. After 1 month of treatment, the facial skin rash of the patient is obviously improved, red papules and pustules are reduced, cysts and nodules are reduced, and the facial greasiness is relieved. After 4 months of treatment, the rash subsides, the face is greasy and dark and is completely improved, and no scar is formed after the cyst and the nodule subside.

Case 2

In 8 months in 2018, a patient is treated with mild pruritus for five years because of 'repeated and frequent skin rash on the face for 5 years and aggravated for 10 more days', and the treatment effect is poor for many people, 25 years old for male. Physical examination: pustules are frequently generated on the forehead, the cheeks, the sides and the periphery of the mouth, a few red papules, cysts, nodules and scars are scattered among the pustules, the face skin is greasy, and the skin is dark in color and luster. And (3) diagnosis: and (3) diagnosis: acne (moderate to severe). After a patient is subjected to conventional acne removal operation, the external traditional Chinese medicine composition is blended into a slightly thick facial mask by using a calamine lotion, the facial mask is smeared to cover the facial areas except the mouth and the eyes, the plaster hot-rolled film is removed after 30 minutes of spreading, and the mask is cleaned. 1 week for 1 time. 1 treatment course comprises 1 week. After 4 treatment courses, the patient's facial skin rash was significantly improved, the red papules and pustules were resolved, the cysts and nodules were reduced, and the facial greasiness was alleviated. The rash subsided in 3 months, the face was greasy and dark and completely improved, and no new scar was formed after the cyst and nodule subsided.

Case 3

Patients were named Ma-Shi, female, 30 years old, and treated with "repeated eruption of face for 3 years, aggravated for more than 1 month" in 7 months in 2018, and examined: red pimple and acne are frequently generated on the forehead and the cheeks, a few of cyst, nodule and pockmark are generated, the face skin is greasy, and the skin color is dark. And (3) diagnosis: acne (moderate mild). After a patient is subjected to conventional acne removal operation, the external traditional Chinese medicine composition is used, fermented glutinous rice juice is blended into a slightly thick mask, the mask is smeared to cover the facial area except the mouth, the nose and the eyes, the plaster hot-rolled film is removed after 30 minutes of application, and the mask is cleaned. 1 week for 1 time. 1 treatment course comprises 1 week. After 1 month of treatment, the facial rash of the patient is obviously improved, the red papules and the pustules are removed, the cysts and the nodules are reduced, and the facial greasiness is relieved. The rash subsides in 2 months, the face is obviously improved in greasy and dark state, and no scar is formed after the cyst and the nodule subside.

Case 4

Zhang, female, 25 years old, in 2019 in 9 months, see a doctor with "rash repeatedly on face for 2 years". Physical examination: the face has acne, pimple, facial part, a few cysts, nodule and pustule, greasy skin and dark skin color. And (3) diagnosis: acne (moderate to severe). After a patient is subjected to conventional acne removal operation, the external traditional Chinese medicine composition is blended into a slightly thick facial mask by using a calamine lotion, the facial mask is smeared to cover the facial areas except the mouth and the eyes, the plaster hot-rolled film is removed after 30 minutes of spreading, and the mask is cleaned. 1 week for 1 time. 1 treatment course comprises 1 week. After 2 weeks of treatment, the facial skin rash of the patient is obviously improved, red papules and pustules are reduced, cysts and nodules are reduced, and the facial greasiness is relieved. After 3 months of treatment, the rash subsides, the face is greasy and dark and is completely improved, and no scar is formed after the cyst and the nodule subside.

Case 5

Ma Chi, male, 27 years old, in 3 months of 2019, the physician needs to see the disease "rash develops repeatedly on the face for 3 years". Physical examination: the face mainly comprises two cheeks and the forehead, and is mainly papules, acnes, multiple cysts, nodules, pustules and scars, greasy skin of the face and dark skin color. And (3) diagnosis: acne (severe, polymeric). After a patient is subjected to conventional acne removal operation, the external traditional Chinese medicine composition is blended into a slightly thick facial mask by using a calamine lotion, the facial mask is smeared to cover the facial areas except the mouth and the eyes, the plaster hot-rolled film is removed after 30 minutes of spreading, and the mask is cleaned. 1 week for 1 time. 1 treatment course comprises 1 week. After 2 treatment courses, the facial rash of the patient is obviously improved, red pustules are reduced, cysts and nodules are reduced, and the facial greasiness is relieved. After 4 months of treatment, the rash subsides, the face is greasy and dark and is completely improved, and no new scar is formed after the cyst and the nodule subside.

Case 6

Li Shi, female, 25 years old, in 6 months of 2020, the diagnosis is mainly "repeated eruption of the face for 4 years, aggravated for more than 1 month". Physical examination: the two cheeks and the forehead of the face are mainly seen as papules, acnes and pustules, a few cysts, nodules and scars (pocks), the skin of the face is greasy, and the skin color is dark. And (3) diagnosis: acne (moderate mild). After a patient is subjected to conventional acne removal operation, the external traditional Chinese medicine composition is used, fermented glutinous rice juice is blended into a slightly thick mask, the mask is smeared to cover the facial area except the mouth and eyes, the plaster hot-rolled mask is removed after 30 minutes of spreading, and the mask is cleaned. 1 week for 1 time. 2 weeks is 1 course of treatment. After 1 month of treatment, the facial skin rash of the patient is obviously improved, red papules and pustules are reduced, cysts and nodules are reduced, and the facial greasiness is relieved. After 3 months of treatment, the rash subsides, the face is greasy and dark and is completely improved, and no scar is formed after the cyst and the nodule subside.

The traditional Chinese medicine considers that acne is mainly caused by that the body has excessive yang heat, the lung channel is internally heated and is repeatedly attacked by wind evil, and the acne is fumigated on the head, the face and the chest and the back to generate sore rash; after being overeated, the head and face are steamed along the channels, because the food is spicy, fat, sweet and thick, or the spleen qi is insufficient, the spleen and the stomach are abnormally transported and transformed, the damp-turbidity is internally stopped, the heat is transformed due to long-term stasis, the damp-heat is internally generated and accumulated in the intestines and the stomach, and the heat cannot be discharged downwards; the pathogenic wind-heat invades the body, and the blood system is affected by the pathogenic wind-heat for a long time, or the body blood heat causes the blood heat to stagnate on the face, and acne is developed.

In the external traditional Chinese medicine composition provided by the invention, the dandelion and the forsythia suspense are used together to play a role of clearing away heat and toxic materials, reducing swelling and resolving masses, and are monarch drugs; the lithospermum, the moutan bark, the thunberg fritillary bulb and the trichosanthes root are used as ministerial drugs for clearing heat and removing toxicity, cooling blood and activating blood, and reducing swelling and resolving masses, and the monarch drugs are used for strengthening the effects of clearing heat and removing toxicity, and have the effects of cooling blood, reducing swelling and resolving masses; the radix sophorae flavescentis and the cortex dictamni strengthen the effects of clearing heat and removing toxicity of monarch drugs and ministerial drugs, have the effects of dispelling wind, eliminating dampness and killing insects and are adjuvant drugs; spina Gleditsiae, Saviae Miltiorrhizae radix, Olibanum, and Myrrha enhance the effects of promoting blood circulation, relieving swelling, and resolving hard mass of principal and ministerial drugs, and are adjuvant drugs, wherein Olibanum and Myrrha also have the effects of treating sore and promoting granulation, and can inhibit scar formation of acne patients; the grassleaf sweelflag rhizome and the raw coix seed not only help monarch drugs and ministerial drugs to reduce swelling and heal wound, but also can clear heat, eliminate dampness and kill parasites, play a role in treating concurrent symptoms and are adjuvant drugs; in addition, the grassleaf sweelflag rhizome, the raw coix seed, the dahurian angelica root and the bitter apricot seed have the functions of drying dampness, whitening and moisturizing the skin, improving the dull and greasy face of patients with acne and are used as adjuvant drugs; ma xing Yi ren gan Tang (herba Ephedrae, radix Coicis semen, semen Armeniacae amarum, and Glycyrrhrizae radix) as guiding drug has effects of opening skin and hair, benefiting lung qi, invigorating spleen soil, and guiding pathogen out, and Glycyrrhrizae radix has effects of clearing heat and detoxicating, and harmonizing the effects of the above drugs.

According to the theory of traditional Chinese medicine of dialectical treatment, the traditional Chinese medicine composition for external use provided by the invention is screened according to the main pathogenesis characteristics of acne, the compatibility is reasonable, the effect is stable, the medicines are cooperated to play the effects of clearing away heat and toxic materials, relieving swelling and resolving masses, activating blood and cooling blood, removing dampness and killing insects, treating sore and promoting granulation, moistening skin and whitening and the like, simultaneously the problems of acne seborrhea and facial darkness can be improved, and the traditional Chinese medicine composition is particularly suitable for treating moderate and severe acne with skin lesions mainly comprising pustules, nodules and cysts; the facial mask provided by the invention is prepared by grinding the external traditional Chinese medicine composition into powder and then uniformly mixing the powder with a proper amount of excipient, has the characteristics of safe use, convenient carrying and the like, can directly act on a pathological change part, has the clinical total effective rate of 90 percent, and is worthy of application and popularization.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention.