阅读说明：本技术 一种植入式颅内压监测装置 (Implanted intracranial pressure monitoring device ) 是由 张月梅 刘艳 赵刚 王磊 刘万鹏 于 2020-02-20 设计创作，主要内容包括：本发明提供一种植入式颅内压监测装置,其包括体外部分,体外部分包括电性连接的第一无线通讯模块和第一数据处理模块,所述第一无线通讯模块包括无线充电单元；体内植入部分,体内植入部分包括用于采集颅内压力的传感部件和用于接收、发射及处理信号的植入电路,所述传感部件通过导线与所述植入电路电性连接,所述植入电路与所述第一无线通讯模块进行无线通讯；所述无线充电单元对所述植入电路进行无线充电。本发明的植入式颅内压监测装置,由于传感部件植入颅内,植入电路和体外部分无线通讯,体外部分向体内植入部分进行无线充电,无导线连接,避免了发生颅内感染的风险,且其结构简单小巧。(The invention provides an implantable intracranial pressure monitoring device, which comprises an external part, a first wireless communication module and a first data processing module, wherein the external part comprises an electric connection, and the first wireless communication module comprises a wireless charging unit; the implantable medical device comprises an implantable part, a first wireless communication module and a second wireless communication module, wherein the implantable part comprises a sensing part for acquiring intracranial pressure and an implanted circuit for receiving, transmitting and processing signals, the sensing part is electrically connected with the implanted circuit through a lead, and the implanted circuit is in wireless communication with the first wireless communication module; the wireless charging unit wirelessly charges the implanted circuit. According to the implantable intracranial pressure monitoring device, the sensing component is implanted into the cranium, the implantation circuit is in wireless communication with the external part, the external part wirelessly charges the internal implantation part, no lead is connected, the risk of intracranial infection is avoided, and the implantable intracranial pressure monitoring device is simple and small in structure.)

1. An implantable intracranial pressure monitoring device, comprising:

the external part (1) comprises a first wireless communication module (11) and a first data processing module (12) which are electrically connected, wherein the first wireless communication module (11) comprises a wireless charging unit (111);

the intracorporeal implantation part (2) comprises a sensing component (21) for acquiring intracranial pressure and an implantation circuit (22) for receiving, transmitting and processing signals, wherein the sensing component (21) is electrically connected with the implantation circuit (22) through a lead (23), and the implantation circuit (22) is in wireless communication with the first wireless communication module (11); the wireless charging unit (111) wirelessly charges the implanted circuit (22).

2. The implantable intracranial pressure monitoring device according to claim 1, further comprising a magnetic attraction apparatus (3), wherein the magnetic attraction apparatus (3) comprises a first magnetic component (31) disposed on the implanted circuit (22) and a second magnetic component (32) disposed on the first wireless communication module (11), and the in-vivo implanted part (2) is magnetically attracted to the in-vitro part (1) through the first magnetic component (31) and the second magnetic component (32).

3. The implantable intracranial pressure monitoring device according to claim 2, wherein the first magnetic component (31) is an electromagnetic component or a permanent magnetic component, and the second magnetic component (32) is an electromagnetic component or a permanent magnetic component.

4. The implantable intracranial pressure monitoring device as recited in claim 1, wherein the sensing element (21) is a first absolute pressure sensor capable of monitoring intracranial pressure in real time and converting intracranial pressure directly into a digital signal for transmission to the implanted circuit (22) via a lead (23).

5. The implantable intracranial pressure monitoring device according to any one of claims 1 or 4, wherein the first wireless communication module (11) further comprises a first signaling unit (112), the first data processing module (12) comprises a power source (121), a first data processing unit (122), and a first data transmission unit (123), and the power source (121) is connected to the wireless charging unit (111), the first signaling unit (112), the first data processing unit (122), and the first data transmission unit (123) at the same time to provide power thereto; the first signal receiving and sending unit (112) is in wireless communication with the implanted circuit (22), and the first signal receiving and sending unit (112), the first data processing unit (122) and the first data transmission unit (123) are sequentially connected to receive, process and transmit data sent by the implanted circuit (22).

6. The implantable intracranial pressure monitoring device according to any one of claims 2 or 3, wherein the first wireless communication module (11) further comprises a first signaling unit (112), the first data processing module (12) comprises a power source (121), a first data processing unit (122), and a first data transmission unit (123), and the power source (121) is connected to the wireless charging unit (111), the first signaling unit (112), the first data processing unit (122), and the first data transmission unit (123) at the same time to provide power thereto; the first signal receiving and sending unit (112) is in wireless communication with the implanted circuit (22), and the first signal receiving and sending unit (112), the first data processing unit (122) and the first data transmission unit (123) are sequentially connected to receive, process and transmit data sent by the implanted circuit (22).

7. The implantable intracranial pressure monitoring device as recited in claim 6, wherein the implantation circuit (22) comprises a second wireless communication module (221) and a second data processing module (222) which are electrically connected, and the second data processing module (222) is connected with the sensing component (21); the second wireless communication module (221) comprises an in-vivo coil circuit (2211) and a second signal receiving and transmitting unit (2212); the wireless charging unit (111) wirelessly charges the in-vivo coil circuit (2211), and the in-vivo coil circuit (2211) is electrically connected with the second signal receiving and transmitting unit (2212), the second data processing module (222) and the sensing component (21) at the same time and used for providing electric energy for the in-vivo coil circuit; the first signaling unit (112) communicates wirelessly with the second signaling unit (2212).

8. The implantable intracranial pressure monitoring device as recited in claim 6, wherein the wireless charging unit (111) is an external coil circuit, and the second magnetic component (32) is disposed at a central position of the external coil circuit.

9. The implantable intracranial pressure monitoring device as recited in claim 7, wherein the first magnetic component (31) is disposed at the center of the in vivo coil circuit (2211).

10. The implantable intracranial pressure monitoring device according to claim 1, wherein the implanted circuit (22), lead (23), and sensing component (21) are each externally encased in a biocompatible material; or the implantation circuit (22) and the lead (23) are both externally wrapped by biocompatible materials, and the sensing part (21) is a pressure sensor with biocompatibility.

11. The implantable intracranial pressure monitoring device as recited in claim 1, wherein the first wireless communication module (11) is configured as a disc-shaped structure having a diameter in the range of 20-50mm and a thickness in the range of 1-3 mm.

12. The implantable intracranial pressure monitoring device as recited in claim 5, wherein the extracorporeal portion (1) further comprises a second absolute pressure sensor (13) for collecting atmospheric pressure in the extracorporeal environment, the second absolute pressure sensor (13) is electrically connected to the first data processing module (12) and the power supply (121), and the first data processing module (12) receives data collected by the first absolute pressure sensor and the second absolute pressure sensor (13) at the same time, calculates the two sets of data, and outputs the calculated data.

13. The implantable intracranial pressure monitoring device as recited in claim 12, wherein the first and second absolute pressure sensors (13) are powered by the same source.

14. The implantable intracranial pressure monitoring device according to claim 12, wherein the external portion (1) further comprises a temperature difference compensation unit (14) connected to the second absolute pressure sensor (13) and the first data processing module (12), the temperature difference compensation unit (14) performs calculation analysis according to the difference between the external ambient temperature and the intracranial temperature of the human body, compensates the pressure signal collected by the second absolute pressure sensor (13) according to the data obtained by calculation analysis, and transmits the compensated data to the first data processing module (12).

15. The implantable intracranial pressure monitoring device according to any one of claims 2-14, wherein the external portion (1) comprises a display unit, the display unit is integrated with the first wireless communication module (11), and the display unit displays intracranial pressure parameters after the internal implanted portion (2) and the external portion (1) are magnetically connected by the magnetic attraction device (3).

16. The implantable intracranial pressure monitoring device according to any one of claims 1-14, further comprising a data display terminal (4) connected to the first wireless communication module (11) by wire or wirelessly; and/or a remote display terminal (5) which is in wireless connection with the first wireless communication module (11).

17. The implantable intracranial pressure monitoring device as recited in claim 16, further comprising a data cloud (6), wherein the wireless communication module 11 transmits data to the data cloud (6) via a mobile network, and the data of the data cloud (6) is transmitted to the remote data display terminal (5) via the mobile network.

18. The implantable intracranial pressure monitoring device as recited in claim 1, wherein the sensing element (21) is fixed between human arachnoid and pia mater or human dura mater and arachnoid or human dura mater and skull.

19. The implantable intracranial pressure monitoring device as recited in claim 18, wherein the sensing element (21) is fixed between the arachnoid and the pia mater, the implanted circuit (22) is embedded between the scalp and the skull, a lead (23) connecting the sensing element (21) and the implanted circuit (22) is disposed through the skull, the dura mater, and the arachnoid in this order, and a lead fixing element made of a biocompatible material is disposed between the skull and the dura mater or between the scalp and the skull.

20. The implantable intracranial pressure monitoring device as recited in claim 18, wherein the pressure-sensing element (21) has a disc structure with a diameter in the range of 1-5mm and a thickness in the range of 0.5-3 mm; or the pressure sensing part (21) is of a cuboid structure, the length range of the pressure sensing part is 0.25-3mm, the width range of the pressure sensing part is 0.1-1mm, and the thickness range of the pressure sensing part is 0.02-0.3 mm.

21. The implantable intracranial pressure monitoring device according to claim 1, wherein the extracorporeal portion (1) is capable of being implanted with a hair ornament or a hat; or the first wireless communication module (11) is implanted into a hair ornament or a hat, and the first data processing module (12) is worn on the neck or shoulders of a human body.

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to an implantable intracranial pressure monitoring device.

Background

The Intracranial Pressure (ICP), i.e., the Pressure of the cerebrospinal fluid in the cranial cavity, is normally 100-. Since the cerebrospinal fluid present in the subarachnoid and intracisternal spaces is between the wall of the cranial cavity and the brain tissue and communicates with the subarachnoid space in the ventricles and the spinal cavity, the hydrostatic pressure of the cerebrospinal fluid can represent the intracranial pressure, which is clinically referred to as increased intracranial pressure when the intracranial pressure generally lasts more than 180 mm of water and lasts for more than 5 minutes. The increased intracranial pressure can cause a series of physiological dysfunction and pathological changes, and the symptoms are headache, nausea, vomit, fundus optic disc edema and the like; and in severe cases even life threatening. Therefore, the intracranial pressure value of the patient can be timely and accurately monitored, and the intracranial pressure monitoring device has very important significance for clinical diagnosis of illness and guidance of treatment. Most neurosurgery clinical units do not have the condition to carry out direct measurement of intracranial pressure, most of the neurosurgery clinical units can carry out the method of implanting the pressure probe into the cranium in a semi-open mode, but the method has high risk of infection, the use time of the pressure probe is short, and the economic burden of a patient is heavy.

Disclosure of Invention

The invention provides an implanted intracranial pressure monitoring device, because the sensing part is implanted into the cranium, the implanted part in vivo and external part of body communicate wirelessly, there is no wire to connect, has avoided the risk of producing intracranial infection; meanwhile, the external part can wirelessly charge the sensing part of the implanted part in the body, so that the sensing part can be left in the skull of the patient for a long time, and the repeated wound of the patient caused by battery replacement is avoided. The implantable intracranial pressure monitoring device comprises an external part, a first wireless communication module and a first data processing module, wherein the external part comprises the first wireless communication module and the first data processing module which are electrically connected, and the first wireless communication module comprises a wireless charging unit; the intracorporeal implantation part comprises a sensing component for acquiring intracranial pressure and an implantation circuit for receiving, transmitting and processing signals, wherein the sensing component is electrically connected with the implantation circuit through a lead, and the implantation circuit is in wireless communication with the first wireless communication module; the wireless charging unit wirelessly charges the implanted circuit.

Optionally, the intracranial pressure monitoring device further includes a magnetic adsorption device, the magnetic adsorption device includes a first magnetic component disposed in the implantation circuit and a second magnetic component disposed in the first wireless communication module, and the in vivo implantation portion and the in vitro portion are connected by magnetic adsorption of the first magnetic component and the second magnetic component.

Optionally, the first magnetic component is an electromagnetic component or a permanent magnetic component, and the second magnetic component is an electromagnetic component or a permanent magnetic component.

Optionally, the sensing component is a first absolute pressure sensor capable of monitoring intracranial pressure in real time and converting the intracranial pressure directly into a digital signal for transmission to the implanted circuit via a lead.

Optionally, the first wireless communication module further includes a first signal receiving and sending unit, the first data processing module includes a power supply, a first data processing unit and a first data transmission unit, and the power supply is connected to the wireless charging unit, the first signal receiving and sending unit, the first data processing unit and the first data transmission unit at the same time to provide electric energy for the wireless charging unit, the first signal receiving and sending unit, the first data processing unit and the first data transmission unit; the first signal receiving and sending unit is in wireless communication with the implanted circuit, and the first signal receiving and sending unit, the first data processing unit and the first data transmission unit are sequentially connected to receive, process and transmit data sent by the implanted circuit.

Optionally, the implantation circuit includes a second wireless communication module and a second data processing module electrically connected to each other, and the second data processing module is connected to the sensing component; the second wireless communication module comprises an in-vivo coil circuit and a second signal receiving and sending unit; the wireless charging unit wirelessly charges the in-vivo coil circuit, and the in-vivo coil circuit is simultaneously electrically connected with the second signal receiving and sending unit, the second data processing module and the sensing component and is used for providing electric energy for the in-vivo coil circuit; the first signal receiving and sending unit and the second signal receiving and sending unit are in wireless communication.

Optionally, the wireless charging unit is an external coil circuit, and the second magnetic component is disposed in a central position of the external coil circuit.

Optionally, the first magnetic component is disposed in a center of the in-vivo coil circuit.

Optionally, the implant circuitry, the lead and the sensing component are externally wrapped with a biocompatible material; or the implant circuit and the lead are both externally wrapped by biocompatible materials, and the sensing component is a pressure sensor with biocompatibility.

Optionally, the first wireless communication module is configured as a disc-shaped structure, and has a diameter ranging from 20 mm to 50mm and a thickness ranging from 1mm to 3 mm.

Optionally, the external part further includes a second absolute pressure sensor for collecting atmospheric pressure in the external environment, the second absolute pressure sensor is electrically connected to the first data processing module and the power supply, and the first data processing module receives data collected by the first absolute pressure sensor and the second absolute pressure sensor at the same time, calculates the two sets of data, and outputs the calculated data.

Optionally, the first absolute pressure sensor and the second absolute pressure sensor are powered from the same source.

Optionally, the extracorporeal part further includes a temperature difference compensation unit connected to the second absolute pressure sensor and the first data processing module, the temperature difference compensation unit performs calculation and analysis according to a difference between an extracorporeal ambient temperature and an intracranial temperature of the human body, compensates a pressure signal acquired by the second absolute pressure sensor according to data obtained by calculation and analysis, and transmits the compensated data to the first data processing module.

Optionally, the extracorporeal part (1) comprises a display unit, the display unit is integrated with the first wireless communication module (11), the intracorporeal implanted part (2) is magnetically attracted to the extracorporeal part (1) by the magnetic attraction device (3), and the display unit displays intracranial pressure parameters.

Optionally, the system further comprises a data display terminal in wired or wireless connection with the first wireless communication module; and/or the remote display terminal is in wireless connection with the first wireless communication module.

Optionally, the intracranial pressure monitoring device further comprises a data cloud, the wireless communication module transmits data to the data cloud through a mobile network, and the data of the data cloud is transmitted to the remote data display terminal through the mobile network.

Optionally, the sensing component is fixed between human arachnoid and pia mater or between human dura mater and arachnoid or between human dura mater and skull.

Optionally, the sensing component is fixed between arachnoid and pia mater, the implantation circuit is embedded between scalp and skull, a lead connecting the sensing component and the implantation circuit is sequentially arranged through the skull, the dura mater and the arachnoid, and a lead fixing component is arranged between the skull and the dura mater or between the scalp and the skull, and is made of a biocompatible material.

Optionally, the pressure sensing part is of a wafer structure, and the diameter range of the pressure sensing part is 1-5mm, and the thickness range of the pressure sensing part is 0.5-3 mm; or the pressure sensing part is of a cuboid structure, the length range of the pressure sensing part is 0.25-3mm, the width range of the pressure sensing part is 0.1-1mm, and the thickness range of the pressure sensing part is 0.02-0.3 mm. Optionally, the extracorporeal portion can be implanted with a hair ornament or a hat; or the first wireless communication module is implanted into a hair ornament or a hat, and the first data processing module is worn on the neck or shoulders of a human body.

Advantageous effects

The implanted intracranial pressure monitoring device has the following beneficial effects:

first, the implantable intracranial pressure monitoring device of the present invention can be wirelessly charged between the external part and the implanted part, so that the sensing component can be left in the cranium of the patient for a long time, and multiple traumas to the patient caused by battery replacement are avoided.

Secondly, the implanted intracranial pressure monitoring device has the advantages that the implanted part in the body and the external part in the body are connected through the magnetic adsorption device, so that the connection is reliable, the implanted intracranial pressure monitoring device is not easy to fall off, and the implanted intracranial pressure monitoring device is convenient to use; moreover, as the sensing component is implanted into the cranium, the implanted circuit is in wireless communication with the external part of the body, and no lead is connected, the risk of intracranial infection is avoided; simultaneously, external part need not be fixed in patient's head for a long time, feels the dizziness or in untimely, and accessible magnetic force adsorption equipment adsorbs the location with external part and internal implantation part and is connected, and then monitors intracranial pressure, uses and convenient to carry.

Thirdly, the implanted intracranial pressure monitoring device adopts the absolute pressure sensor, has accurate monitoring and high precision, directly converts the analog signal into the electronic signal and transmits the electronic signal through a lead, and avoids the problem of inaccurate numerical precision caused by the attenuation of the analog signal caused by voltage, current and surrounding electromagnetic interference introduced by analog quantity in the data transmission process.

Fourthly, the implanted intracranial pressure monitoring device adopts an absolute pressure sensor, is provided with a sensing component which is used for external comparison and is provided with a power supply, and can carry out zero point correction on a monitoring numerical value according to air pressure data in an external environment.

Fifth, the sensing component implanted in the body of the implanted intracranial pressure monitoring device has a small structure and is convenient to implant.

Sixth, the implanted intracranial pressure monitoring device of the invention has a small structure in the external part, can be implanted with hair ornaments or hats, is convenient to carry, and does not affect the external image of the patient.

Seventhly, the external part of the implanted intracranial pressure monitoring device can be divided into two parts for fixation, the first wireless communication module can be implanted with a hair band, a hair clip, a cap and the like, is fixed at the external implantation position corresponding to the internal implantation part and is arranged close to the scalp, so that reliable data transmission can be ensured, the weight of the device is light, and the device can not bring load and discomfort to the head of a patient; and the first data processing module has larger mass due to the battery, can be worn on the neck or shoulders and is convenient to use.

Eighth, the display component is integrated with the external part of the implanted intracranial pressure monitoring device, and when a patient feels dizziness or discomfort, the display component can conveniently display intracranial pressure parameters in real time after the external part and the implanted part are adsorbed, positioned and connected through the magnetic adsorption device.

Ninth, the implanted intracranial pressure monitoring device is also provided with a temperature difference compensation unit, so that the influence of the error of the sensing part caused by the ambient temperature on the monitoring precision of the implanted intracranial pressure monitoring device can be avoided when the ambient temperature changes.

Drawings

Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present invention. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the invention, as detailed in the claims.

FIG. 1 is a schematic diagram of an embodiment of an implantable intracranial pressure monitoring apparatus according to the present invention;

FIG. 2 is a schematic diagram of another embodiment of an implantable intracranial pressure monitoring apparatus according to the invention;

FIG. 3 is an electromagnetic induction schematic diagram of an implantable intracranial pressure monitoring device according to the present invention;

fig. 4 is an electrical schematic diagram of the implanted intracranial pressure monitoring device of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1, the implantable intracranial pressure monitoring device of the present invention comprises: the external part 1 comprises a first wireless communication module 11 and a first data processing module 12, the first wireless communication module 11 is electrically connected with the first data processing module 12, and the first wireless communication module 11 comprises a wireless charging unit 111; the in-vivo implanted part 2 comprises a sensing part 21 and an implanted circuit 22 which are connected through a lead 23, the implanted circuit 22 can be in wireless communication with the first wireless communication module 11, the sensing part 21 is used for collecting intracranial pressure, and the implanted circuit 22 can receive pressure signals of human body intracranial collected by the sensing part 21 through the lead 23 and wirelessly transmit the pressure signals to the first wireless communication module 11 of the in-vitro part 1 after processing the pressure signals; the wireless charging unit 111 wirelessly charges the implant circuit 22. The sensing part of the implanted intracranial pressure monitoring device is implanted into the cranium, the in-vivo implanted part 2 is in wireless communication with the in-vitro part 1, and no lead is connected, so that the risk of intracranial infection is avoided; meanwhile, the external part 1 can wirelessly charge the sensing part 21 in the body, so that the sensing part 21 can be left in the skull of the patient for a long time, and the repeated wound of the patient caused by battery replacement is avoided.

The intracranial pressure monitoring device of the invention also comprises a magnetic adsorption device 3 which connects and fixes the in-vivo implanted part 2 and the in-vitro part 1. Specifically, the magnetic attraction device 3 includes a first magnetic component 31 disposed on the implanted circuit 22 and a second magnetic component 32 disposed on the first wireless communication module 11, and the in-vivo implanted portion 2 and the in-vitro portion 1 are magnetically attracted and connected through the first magnetic component 31 and the second magnetic component 32. Because the in-vivo implanted part 1 and the in-vitro part 2 are connected through the magnetic adsorption device 3, no lead or catheter is needed to be connected between the in-vivo part and the in-vitro part, the risk of intracranial infection is avoided, and meanwhile, the connection is firm and reliable, and the normal movement of a patient is not limited.

Alternatively, the first magnetic part 31 and the second magnetic part 32 of the magnetic force adsorption device 3 may be both permanent magnetic parts or electromagnetic parts.

Alternatively, the sensing part 21 employs an absolute pressure sensor (for convenience of description, this sensing part 21 will be described as a first absolute pressure sensor 21 hereinafter). The first absolute pressure sensor 21 is used for collecting intracranial pressure, directly converting the intracranial pressure into a digital signal, and transmitting the digital signal to the implantation circuit 22 through the lead 23, and the implantation circuit 22 transmits the digital signal to the first wireless communication module 11 of the extracorporeal part 1 through a wireless communication mode. The absolute pressure sensor 21 can convert the analog quantity of the acquired intracranial cerebrospinal fluid pressure into digital quantity for output, and the problem of inaccurate numerical value precision caused by attenuation and interference of analog signals caused by voltage, current and surrounding electromagnetic interference introduced by the analog quantity in the data transmission process is solved.

Specifically, the first wireless communication module 11 includes the wireless charging unit 111 and the first signal receiving and sending unit 112, the first data processing module 12 includes a power source 121, a first data processing unit 122 and a first data transmission unit 123, and the power source 121 is connected to the wireless charging unit 111, the first signal receiving and sending unit 112, the first data processing unit 122 and the first data transmission unit 123 at the same time to provide electric energy for them; the first signal receiving and sending unit 112 performs wireless communication with the implanted circuit 22, and can receive signal data transmitted by the implanted circuit 22, and the first signal receiving and sending unit 112, the first data processing unit 122, and the first data transmission unit 123 are sequentially connected to process and transmit the signal data received by the first signal receiving and sending unit 112; the wireless charging unit 111 is used for wirelessly charging the implanted circuit 22. The power supply 121 may be a mobile rechargeable battery, a general battery, or a charger.

Specifically, the implantation circuit 22 includes a second wireless communication module 221 and a second data processing module 222 which are electrically connected, the second data processing module 222 is electrically connected to the first absolute pressure sensor 21, and the second wireless communication module 221 includes a body coil circuit 2211 and a second signal receiving and sending unit 2212; the wireless charging unit 111 wirelessly charges the in-vivo coil circuit 2211, and the in-vivo coil circuit 2211 is simultaneously electrically connected with the second signal receiving and transmitting unit 2212, the second data processing module 222 and the first absolute pressure sensor 21 for providing electric energy thereto; the first signaling unit 112 communicates wirelessly with the second signaling unit 2212.

The wireless charging unit 111 is specifically an external coil circuit, and the second magnetic component 32 is disposed at a central position of the external coil circuit. The first magnetic member 31 is provided at the center of the in-vivo coil circuit 2211. Specifically, the external coil circuit is in a circular or elliptical structure, the diameter range of the external coil circuit is 20-50mm, and the thickness range of the external coil circuit is 1-3 mm.

Referring to fig. 3, the principle of wirelessly charging the in-vivo coil circuit 2211 by the in-vitro coil circuit and the process thereof are as follows.

The electromagnetic induction principle is adopted, and energy is coupled through the coil to realize energy transfer. When the system works, the input end converts alternating current low-frequency commercial power into direct current through full-bridge rectification, and the direct current output by the power management circuit is converted into high-frequency alternating current through 2M active crystal oscillator inversion to be supplied to an external coil (primary winding) circuit. Energy is coupled through the 2 inductance coils, and the current output by the internal coil (secondary coil) circuit is converted into direct current to be output through the receiving and converting circuit.

For some patients, it is desirable to monitor intracranial pressure in real time for a long period of time or multiple times, and the first absolute pressure sensor 21 acts as an electronic sensing element, requiring a stable power source for its operation. Through the setting of above-mentioned wireless charging unit 111, can keep the first absolute pressure sensor 21 long-term encephalic, avoid the patient to receive many times unnecessary wound because of implanting sensing element many times to reduce the infection risk.

Further, since the intracorporeal implantation portion 2 is an implantation portion in a human body, the implantation circuit 22, the lead 23 and the sensing component 21 are externally wrapped with a biocompatible material, specifically, the biocompatible material may be a medical polymer biomaterial, such as medical silica gel, or a medical metal material, such as titanium alloy, or a medical inorganic material, such as ceramic. Specifically, the second wireless communication module 221 is externally wrapped with a medical polymer biomaterial such as silica gel; the second data processing module 222 is externally wrapped with a medical metal material such as titanium alloy; the outer parts of the lead 23 and the sensing part 21 are made of medical polymer biological materials; or the pressure sensing part 21 is a pressure sensor having biocompatibility. The second data processing module 222 is approximately coin-sized and is small to facilitate implantation into the cranium.

Furthermore, the range of the standard value of the intracranial pressure of the human body can change along with the change of the atmospheric pressure in the external environment where the human body is located, so that in order to further more accurately monitor the intracranial pressure of the human body in the environment with different atmospheric pressures, the implanted intracranial pressure monitoring device can also be provided with a sensing component for monitoring the atmospheric pressure in the surrounding environment. Specifically, referring to fig. 2, a second absolute pressure sensor 13 is disposed in the extracorporeal portion 1, and the second absolute pressure sensor 13 is electrically connected to the first data processing module 12 and the power source 121. In the working state of the monitoring device, the first absolute pressure sensor 21 collects intracranial cerebrospinal pressure, the pressure signal is directly converted into a digital signal and transmitted to the implantation circuit 22 through the lead 23, the implantation circuit 22 transmits the pressure signal to the first wireless communication module 11 in a wireless communication mode, the second absolute pressure sensor 13 monitors the pressure in the external environment and transmits the pressure signal to the first data processing module 12 through a connecting line, the first data processing module 12 simultaneously receives intracranial pressure signal data transmitted by the first wireless communication module 11 and atmospheric pressure signal data collected by the second absolute pressure sensor 13 in the environment, compares the two groups of pressure signal data, and outputs a comparison result. In this way, by providing the absolute pressure sensor for comparison for monitoring the atmospheric pressure in the external environment, the zero point correction can be performed on the intracranial monitoring value based on the atmospheric pressure data in the external environment. Therefore, the condition that the intracranial pressure monitoring data is inaccurate due to the change of the atmospheric pressure in the external environment is avoided, and the precision of the monitoring device is further improved.

Optionally, the range of the standard value of the intracranial pressure of the human body may change with the change of the temperature in the external environment where the human body is located, and therefore, in order to further more accurately monitor the intracranial pressure of the human body at different external environment temperatures, the implanted intracranial pressure monitoring apparatus of the present invention may further be provided with a temperature difference compensation unit 14 for monitoring the ambient temperature and compensating the pressure signal data monitored by the second absolute pressure sensor 13 according to the monitoring data. The temperature compensation unit 14 is connected between the second absolute pressure sensor 13 and the first data processing module 12, and is configured to perform temperature difference compensation on the ambient pressure monitored by the second absolute pressure sensor 13 according to the temperature in the external environment, compare the compensated data with the data monitored by the first absolute pressure sensor 21, and output a comparison result, thereby improving the monitoring accuracy. In addition, because the measurement errors of the absolute pressure sensors at different temperatures are different, the measurement errors of the absolute pressure sensors can be corrected by arranging the temperature difference compensation unit 14, and the monitoring accuracy is improved.

Through the arrangement of the second absolute pressure sensor 13 and the temperature difference compensation unit 14, the monitoring accuracy of the monitoring device of the invention is not changed along with the change of the temperature or the geographical position in the external environment.

Further, the first absolute pressure sensor 21 and the second absolute pressure sensor 13 are supplied with power from the same source, so that the influence of the two sets of sensing parts on the monitoring result due to different voltages or voltage fluctuation can be eliminated. Specifically, the in-vivo coil circuit 2211 may supply power to the first absolute pressure sensor 21 while wirelessly supplying power to the second absolute pressure sensor 13, or the power supply 121 of the extracorporeal portion 1 may supply power to the second absolute pressure sensor 13 while wirelessly supplying power to the first pressure sensor 21.

The first absolute pressure sensor 21 of the monitoring device of the present invention may be fixed between the arachnoid and the pia mater or between the dura mater and the arachnoid or between the dura mater and the skull of a human. Preferably fixed between the arachnoid and the pia mater of the human body, the implanted circuit 22 is embedded between the scalp and the skull, one end of the lead 23 is connected with the implanted circuit 22, and the other end is connected with the first insulation pressure sensor 21 after sequentially passing through the skull, the dura mater and the arachnoid. Since there is cerebrospinal fluid between arachnoid and pia mater, the first absolute pressure sensor 21 is easy to move in the cerebrospinal fluid, so a lead fixing part (not shown in the figure) is arranged between the skull and the dura mater or between the scalp and the skull, and the lead fixing part can fix the lead 23 relative to the skull, thereby preventing the problem of inaccurate monitoring data caused by the play of the lead 23 causing the play of the first absolute pressure sensor 21. For example, a lead fixation member, embodied as a circular boss formed of a medical grade polymer biomaterial, is disposed between the scalp and the skull and attached to the outer craniofacial surface with conformity with the implant circuitry 22. After the scalp is sutured, the pressure measuring instrument is attached between the skull and the scalp at the position needing pressure measurement. Optionally, the extracorporeal part 1 further includes a display unit (not shown in the figure), the display unit may be directly integrated on the first wireless communication module 11 of the extracorporeal part 1, when measurement is needed, for example, when a patient feels light-headed or uncomfortable, or intracranial pressure needs to be monitored according to a requirement of periodic tracking and re-examination, the extracorporeal part 1 is close to the intracorporeal implanted part 2, and is searched and positioned by the magnetic adsorption device 3, and after the extracorporeal part 1 and the intracorporeal implanted part 2 are positioned and connected, intracranial pressure data monitored by the first absolute pressure sensor 21 in real time is displayed by the display unit. The monitoring is convenient and the data reading is convenient, and meanwhile, the external part 1 does not need to be fixed on the head of the patient for a long time, so that the load of the head of the patient is reduced. Alternatively, referring to fig. 2, the monitoring device of the present invention further includes a data display terminal 4, and the data display terminal 4 is connected with the first wireless communication module 11 in a wired or wireless manner. The data display terminal 4 can be a common LED display screen or other displays and is connected with the first wireless communication module through a line; the data display terminal 4 may also be a mobile phone, a Pad, or other electronic devices, and the data display terminal 4 and the first wireless communication module 11 perform wireless communication, and the specific wireless communication mode may be bluetooth, WIFI, or the like.

The monitoring device of the invention may further comprise a remote data display terminal 5 and a data cloud 6. Data can be output from the first wireless communication module 11 or the display terminal 4 to the remote data display terminal 5 through the internet or a mobile network; or the data can be uploaded to the data cloud 6 from the first wireless communication module 11 or the display terminal 4 through the internet or a mobile network, and then transmitted to the remote data display terminal 5 to be read by the data cloud 6. The remote data display terminal 5 can be a computer, a mobile phone and other devices in a hospital, or a computer, a mobile phone and other devices in the family members of a patient, or any available terminal device needing to be displayed. The remote data terminal can display the monitored dynamic data, and can perform early warning according to the monitored dynamic data to remind a patient or a doctor or related personnel to make a diagnosis and treatment in time. Meanwhile, medical staff or operating staff can also set the monitoring device to zero at the remote data display terminal 5.

When a patient is at home or in other places except a hospital, if the patient feels dizzy, the intracranial pressure can be measured in real time by starting the monitoring device, and the measurement data is transmitted to the electronic equipment of the hospital, and the electronic equipment of the hospital can remotely monitor the intracranial pressure of the patient and can set high-pressure early warning. Therefore, doctors can remotely observe monitoring data, timely know the illness state of patients and remotely guide the patient, so that the patients can be guaranteed to have free activity spaces, and meanwhile, the safety of the patients can be guaranteed, and emergencies are prevented.

Because the monitoring device is provided with the data cloud 6 for storing data, the data cloud 6 can store and backup the data of the data display terminal 4 or the remote data display terminal 5; when needed, medical staff can call all data records at any time to comprehensively analyze the intracranial pressure condition and diseases of the patient. The data storage is safe and reliable, and the lookup is convenient.

In summary, the implantable intracranial pressure monitoring device of the present invention has various display manners of monitoring data, and can be directly displayed on the display component integrated on the first wireless communication module 11 of the extracorporeal portion 1, or displayed on the data display terminal 4 wired or wirelessly connected to the first wireless communication module 11, or displayed on the remote data display terminal 5 in a wireless manner; of course, in order to facilitate the patient himself and the medical staff to read the monitoring data at the same time, the three display modes can be performed simultaneously.

Further, the first absolute pressure sensor 11 is preferably a disk-shaped structure, and the diameter range thereof is approximately 1-5mm, and the thickness range thereof is 0.05-3 mm; more preferably, the diameter is 1 to 2mm and the thickness is 0.5 to 3 mm. The pressure sensor with the structure is small and exquisite in structure, light in weight and easy to implant and fix.

Or, the pressure sensing part 21 is a cuboid structure, the length range of which is 0.25mm-3mm, the width range of which is 0.1-1mm, and the thickness range of which is 0.02-0.3 mm; preferably, the pressure sensing part 21 has a length ranging from 0.5 to 1mm, a width ranging from 0.1 to 0.5mm, and a thickness ranging from 0.02 to 0.1 mm; still more preferably, the pressure sensing member 21 has a length of 0.75mm, a width of 0.22mm and a thickness of 0.075 mm. The size range of the pressure sensing component 21 is further reduced, so that the pressure sensing component can be implanted into a body more conveniently, and the wound to a patient is greatly reduced. In addition, the external part 1 can be implanted with hair ornaments or hats and the like, so that the external part is convenient to wear, is firmly fixed and is hidden, and the external image of a patient cannot be influenced. Or the external part can be divided into two parts for fixing, the first wireless communication module 11 can be implanted with a hair band, a hair clip, a hat and the like, is fixed at the corresponding external position of the internal implanted part 2 and is arranged close to the scalp, so that reliable data transmission can be ensured, the weight is light, and the load and discomfort of the head of a patient can not be brought; the first data processing module 12 has a large mass due to the battery, can be worn on the neck or shoulders, and is convenient to use.

The working principle and the working process of the monitoring device of the invention can be seen in the electrical composition schematic diagram of fig. 4. In fig. 4, the MCU of the external part corresponds to the first data processing module 12, and the MCU of the implanted part corresponds to the second data processing module 222.

Description of the relationship of the signal from intracranial transmission to the action of the mobile terminal: an intracranial implanted absolute pressure sensor 21 senses an intracranial pressure signal; the implanted lead 23 transmits the pressure signal to the implanted circuit 22 between the subcutaneous and cranial bones; the implantation circuit 22 transmits the digital pressure signal to the first wireless communication module 11 of the body external part 1 through the second wireless communication module 221; the digital pressure signal received by the first wireless communication module 11 of the extracorporeal part 1 is processed and then output to the data display terminal 4; transmitted to the remote data display terminal 5 through the internet or mobile network. In the case where the second absolute pressure sensor 13 is provided, the first wireless communication module 11 receives the monitoring data of the first absolute pressure sensor 21 and the second absolute pressure sensor 13 at the same time, and outputs the result of comparison to the display terminal 4 or the remote data display terminal 5. Description of power supply transmission relationship: the extracorporeal part 1 can be powered by a mobile rechargeable battery; the current is coupled out of the magnetic field through the wireless charging unit 111 of the external circuit; the magnetic field is radiated to the body coil circuit 2221 of the implanted circuit 22 to generate a current, which is rectified by the power management module of the body coil circuit 2221 to continuously supply power to the implanted circuit 22 and the first isolated pressure sensor 21. The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.